[Role of the conformation changement of CD4 in the HIV-cell fusion] NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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[Role of the conformation changement of CD4 in the HIV-cell fusion]

C R Acad Sci III. 1997 Feb;320(2):163-70. Unique Identifier : AIDSLINE MED/97325053
Sanejouand YH; Laboratoire de physique quantique, UMR 5626 du CNRS, IRSAMC,; Universite Paul-Sabatier, Toulouse, France.

Abstract: It is well known that the gp120-gp41 complex undergoes a conformational change after CD4 binding. It is likely that CD4 undergoes a conformational change as well. Recently, a calculation of the normal modes of the two N-terminal domains of CD4 has shown that a hinge-bending motion of one of these domains with respect to the other may occur. In the present study, results obtained previously are verified with two other normal mode calculations, starting from crystallographic structures of different origin. A scheme describing the first steps of the process leading to cell infection by human immunodeficiency virus HIV) is then proposed. It rests upon the idea that CD4 and gp120-gp41 conformational changes allow for bringing the cell and virus membranes closer to each other.
Keywords: *Antigens, CD4/CHEMISTRY *Cell Fusion/IMMUNOLOGY *HIV/PHYSIOLOGYKWDantigens,cd4/chemistryKWDcellfusion/immunologyKWDhiv/physiology
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Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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