Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection.

Clin Microbiol Rev. 1997 Apr;10(2):358-67. Unique Identifier : AIDSLINE MED/97259659
Weissman D; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-1576, USA. dweissman@nih.gov

Abstract: The role of dendritic cells (DC) in the pathogenesis of human immunodeficiency virus (HIV) disease has been a subject of considerable interest for several years. Initial studies focused on the infection, dysfunction, and depletion of DC in HIV-infected individuals. More recent studies have begun to identify the functional role of DC in the initiation and propagation of viral replication in T cells in HIV-infected individuals. This review discusses recent data regarding the role of DC in HIV disease with the aim of delineating basic immunopathogenic principles of infection and the development of therapeutic strategies.
Keywords: *Dendritic Cells/IMMUNOLOGY *Dendritic Cells/PHYSIOLOGY *HIV Infections/IMMUNOLOGYKWDdendriticcells/immunologyKWDdendriticcells/physiologyKWDhivinfections/immunology
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Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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