Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment.

Cancer Immunol Immunother. 1997 Apr;44(2):77-82. Unique Identifier : AIDSLINE MED/97320617
Belfrage H; Dohlsten M; Hedlund G; Kalland T; Department of Cell and Molecular Biology, Lund University, Sweden.

Abstract: Injection of the superantigen staphylococcal enterotoxin A (SEA) activates both CD4+ and CD8+ T cells expressing certain families of T cell receptor (TCR) variable-region beta (V beta) chain. T cells respond with profound cytokine production and induction of cytotoxicity. Repeated injections, however, cause deletion and anergy of both CD4+ and CD8+ T cells, resulting in reduced frequency of SEA-responsive cells TCR-V beta11+ as well as reduced cytokine levels in serum upon challenge with SEA. Exogenous interleukin-2 (IL-2) in vivo rescued SEA-responsive CD4+ and CD8+ cells from SEA-induced deletion and/or increase expansion of SEA-primed cells as well as preventing downregulation of endogenous IL-2 production in vivo. Combined treatment with SEA and IL-2 also superinduced production of important cytokines for the cytotoxic function of T cells, tumour necrosis factor alpha, interferon gamma and IL-6, on a cellular level. These studies show that continuous stimulation with IL-2 in vivo could be useful for superantigen-based immunotherapy by induction of excessive T cell activation and by prevention of the development of T cell deletion and anergy.
Keywords: *Enterotoxins/PHARMACOLOGY *Immune Tolerance/DRUG EFFECTS *Interleukin-2/PHARMACOLOGY *Staphylococcus aureus/IMMUNOLOGY *Superantigens/PHARMACOLOGYKWDenterotoxins/pharmacologyKWDimmunetolerance/drugeffectsKWDinterleukin-2/pharmacologyKWDstaphylococcusaureus/immunologyKWDsuperantigens/pharmacology
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