Circulating CD8 T cells show increased interferon-gamma mRNA expression in HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Circulating CD8 T cells show increased interferon-gamma mRNA expression in HIV infection.

Cell Immunol. 1997 May 25;178(1):91-8. Unique Identifier : AIDSLINE MED/97328144
Breen EC; Salazar-Gonzalez JF; Shen LP; Kolberg JA; Urdea MS; Martinez-Maza O; Fahey JL; Department of Microbiology and Immunology, University of California,; Los Angeles 90095-1747, USA. ebreen@ucla.edu

Abstract: IFN-gamma mRNA levels were measured in unstimulated PBMC and purified cell subpopulations, utilizing branched DNA assays, to characterize the cell type(s) that contribute to the in vivo increase in IFN-gamma gene expression seen in HIV infection. PBMC and CD8 T cells from HIV-seropositive subjects (HIV+) showed 2.5-fold increases in mean IFN-gamma mRNA levels compared to HIV-uninfected subjects (HIV-). Within individuals, CD8 T cells showed the highest IFN-gamma expression regardless of HIV status, which suggests that HIV infection enhances the IFN-gamma gene expression in CD8 T cells rather than inducing a shift to and/or increasing expression of IFN-gamma mRNA in other cell types. HIV+ subjects with increased PBMC IFN-gamma mRNA had elevated plasma levels of HIV RNA, neopterin, and beta 2-microglobulin. No differences in IFN-gamma mRNA levels were seen among HIV+ stratified by CD4 T cell number. Increased IFN-gamma may result from or be a contributing factor to increased viral load.
Keywords: *CD8-Positive T-Lymphocytes/METABOLISM *Gene Expression Regulation *HIV Infections/IMMUNOLOGY *Interferon Type II/BIOSYNTHESIS *RNA, Messenger/BIOSYNTHESISKWDcd8-positivet-lymphocytes/metabolismKWDgeneexpressionregulationKWDhivinfections/immunologyKWDinterferontypeii/biosynthesisKWDrna,messenger/biosynthesis
970930
M9791366

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1997. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1997. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .