Spectrum of clinical and laboratory characteristics of HIV infection in northern India.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Spectrum of clinical and laboratory characteristics of HIV infection in northern India.

J Commun Dis. 1995 Sep;27(3):131-41. Unique Identifier : AIDSLINE MED/97306405
Giri TK; Pande I; Mishra NM; Kailash S; Uppal SS; Kumar A; Department of Medicine, All India Institute of Medical Sciences, New; Delhi.

Abstract: To define the impact of HIV infection in India, the clinical and laboratory profile and the correlation of CD4 count to the likely opportunistic infection in a cohort of 134 HIV positive patients in Northern India was analysed. Majority of the patients, 72% and 67.8% (children and adults respectively) were asymptomatic, having been detected during routine screening and maintained that status for a median follow-up period of 3 years. Among the symptomatic patients, oropharyngeal candidiasis was the most common opportunistic infection followed closely by tuberculosis both pulmonary and extra pulmonary) around 3.6-4.0 years from probable HIV infection with a median CD4 of 420-578 per cmm. Infection with Cryptococcosis, Cryptosporidiosis and cytomegalovirus occurred only after a significant fall in CD4 to < 100/cmm usually around 8-10 years from probable HIV infection. Pneumocystis carinii pneumonia was the terminal event among the 12 deaths at a mean CD4 count of 6/cmm. Non specific constitutional symptoms like fever, prolonged diarrhoea and significant weight loss were frequent. In general, the clinical profile of Indian patients with HIV bears much resemblance to African countries owing perhaps to the similar background of poverty, malnutrition and endemic infection.

Keywords: *AIDS-Related Opportunistic Infections/MICROBIOLOGY
970930
M9791339

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