No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders.

J Invest Dermatol. 1997 Jun;108(6):920-2. Unique Identifier : AIDSLINE MED/97325810
Henghold WB 2nd; Purvis SF; Schaffer J; Giam CZ; Wood GS; Department of Dermatology, Case Western Reserve University, Cleveland,; Ohio, USA.

Abstract: The recently discovered human virus known as Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 HHV-8) has been associated with body-cavity-based lymphomas in AIDS patients. It is most closely related to two other herpesviruses, the Epstein-Barr virus and herpesvirus saimiri, which are known to be associated with lymphomas in humans and nonhuman primates, respectively. To determine whether KSHV/HHV-8 is involved in the pathogenesis of mycosis fungoides (MF) and related disorders, we used a genomic PCR assay followed by confirmatory Southern blot analysis with a nested oligonucleotide probe to analyze cases for the presence of this virus. The specimens studied included fresh-frozen lesional tissues obtained from 16 patients with MF, seven with lymphomatoid papulosis, seven with primary cutaneous CD30+ large cell lymphoma of T-cell lineage, and five with Hodgkin's disease. Two T-cell tumor lines were also studied: MT4 (derived from a patient with adult T-cell leukemia/lymphoma) and Jurkat (derived from a patient with T-cell acute lymphoblastic leukemia). All cases were uniformly negative for KSHV/HHV-8, whereas Kaposi's sarcoma-positive controls and human beta-globin DNA integrity controls were appropriately positive. These findings provide strong evidence against a role for KSHV/HHV-8 in the pathogenesis of MF or associated lymphoproliferative disorders.

Keywords: *Herpesvirus, Kaposi's Sarcoma-Associated/PHYSIOLOGY *Hodgkin's Disease/VIROLOGY *Lymphoma, Large-Cell/VIROLOGY *Mycosis Fungoides/VIROLOGY *Skin Diseases, Papulosquamous/VIROLOGY *Skin Neoplasms/VIROLOGY
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