Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions.

J Infect Dis. 1997 Jun;175(6):1324-32. Unique Identifier : AIDSLINE MED/97323974
Webster-Cyriaque J; Edwards RH; Quinlivan EB; Patton L; Wohl D; Raab-Traub N; Department of Microbiology and Immunology and Lineberger Cancer; Center, University of North Carolina at Chapel Hill, 27599-7295, USA.

Abstract: The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi's sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymerase chain reaction (PCR) for EBV and HHV-8 DNA and by Southern blot analysis for EBV clonality. EBV was detected by Southern blot in hairy leukoplakia lesions, in a subset of AIDS-related lymphomas, and in saliva from HIV-positive persons but not in pseudohairy leukoplakia lesions, oral aphthous ulcers, or oral KS lesions. EBV was detected, however, by PCR in most of the lesions, while HHV-8 was detected only in oral KSs. The absence of HHV-8 DNA in both the EBV-associated hairy leukoplakia lesions and in the EBV-associated AIDS-related lymphomas strengthens the etiologic relationship of EBV to these pathologies and the etiologic role of HHV-8 in KS.
Keywords: *AIDS-Related Opportunistic Infections/VIROLOGY *Herpesviridae Infections/VIROLOGY *Herpesvirus 4, Human/ISOLATION & PURIF *Herpesvirus, Kaposi's Sarcoma-Associated/ISOLATION & PURIF *Mouth Diseases/VIROLOGYKWDaids-relatedopportunisticinfections/virologyKWDherpesviridaeinfections/virologyKWDherpesvirus4,human/isolation&purifKWDherpesvirus,kaposi'ssarcoma-associated/isolation&purifKWDmouthdiseases/virology
970930
M9791337

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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