Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hosts.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hosts.

J Infect Dis. 1997 Jun;175(6):1352-9. Unique Identifier : AIDSLINE MED/97323978
Michael NL; Brown AE; Voigt RF; Frankel SS; Mascola JR; Brothers KS; Louder M; Birx DL; Cassol SA; Division of Retrovirology, Walter Reed Army Institute of Research, and; Henry M. Jackson Foundation, Rockville, Maryland 20850, USA.

Abstract: A patient is described who rapidly progressed from primary human immunodeficiency virus (HIV) type 1 infection to death without seroconversion but with consistently high plasma viremia. His asymptomatic sex partner had been HIV-1 seropositive for >8 years prior to transmission. Analysis of viral sequences from these subjects and controls confirmed the transmission event. Although the biologic properties of the patient's virus were unremarkable, he had poor functional immune responses to HIV and an HLA haplotype associated with rapid disease progression. The disparity between immune responses and clinical course in this transmission pair, coupled with infection with an unremarkable HIV-1 isolate, underscores the crucial importance of host factors in HIV-1 pathogenesis.

Keywords: *HIV Infections/VIROLOGY *HIV Seronegativity/IMMUNOLOGY *HIV-1/PHYSIOLOGY
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