Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair.

J Infect Dis. 1997 Jun;175(6):1510-5. Unique Identifier : AIDSLINE MED/97324000
Wang B; Ge YC; Jozwiak R; Bolton W; Palasanthiran P; Ziegler J; Chang J; Xiang SH; Cunningham AL; Saksena NK; Centers for Virus Research, Westmead Institutes for Health Research,; Westmead Hospital, NSW, Sydney, Australia.

Abstract: Molecular analyses were done for the V3 region quasispecies of human immunodeficiency virus type 1 (HIV-1) strains from plasma and peripheral blood mononuclear cells of the first HIV-1-infected long-term-nonprogressing mother-child pair whose members have survived for >13 years with stable CD4 T cell counts. There was a predominance of lower V3 loop charge and the absence of genotypic changes that are critical in phenotypic determination and tropism during HIV-1 infection. The intrahost genetic diversity between HIV-1 strains from the mother-child pair compared with HIV-1 strains from slow and rapid progressors suggested that a high genetic heterogeneity in HIV-1 strains from this HIV-1-infected long-term-nonprogressing mother and child pair was directly proportional to the length of their immunocompetent period.

Keywords: *HIV Envelope Protein gp120/GENETICS *HIV Infections/VIROLOGY *HIV-1/GENETICS *Peptide Fragments/GENETICS *Variation (Genetics)/GENETICS
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M9791326

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