Infection of human monocytes with Mycobacterium tuberculosis enhances human immunodeficiency virus type 1 replication and transmission to T cells. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Infection of human monocytes with Mycobacterium tuberculosis enhances human immunodeficiency virus type 1 replication and transmission to T cells.

J Infect Dis. 1997 Jun;175(6):1531-5. Unique Identifier : AIDSLINE MED/97324005
Mancino G; Placido R; Bach S; Mariani F; Montesano C; Ercoli L; Zembala M; Colizzi V; Department of Biology, University of Rome Tor Vergata, Institute of; Experimental Medicine, National Research Council, Italy.

Abstract: Mycobacterium tuberculosis and human immunodeficiency virus type 1 (HIV-1) are virulent intracellular pathogens that invade and multiply within macrophages. The effect of M. tuberculosis on HIV-1 infection and replication was analyzed in vitro using human monocyte-derived macrophages (MDM) isolated from peripheral blood mononuclear cells by countercurrent centrifugal elutriation. Preinfection of MDM with M. tuberculosis followed by HIV-1 infection resulted in an increase in p24 release, reverse transcriptase activity, and infective virus production. In contrast, no increase in HIV-1 production was observed when MDM were infected with Mycobacterium avium complex or heat-killed M. tuberculosis. Coinfected MDM were potent stimulators of T cell proliferation, while HIV-1-infected MDM failed to present exogenous tuberculin to T cells. Furthermore, coinfected MDM showed an increased capacity to transmit HIV-1 to activated T cells. These results suggest that M. tuberculosis infection can both up-regulate HIV-1 infection and replication within MDM and increase the efficiency of virus transmission from infected MDM to T cells.
Keywords: *HIV-1/PHYSIOLOGY *Monocytes/MICROBIOLOGY *Mycobacterium tuberculosis/PHYSIOLOGY *T-Lymphocytes/VIROLOGY *Virus Replication/PHYSIOLOGYKWDhiv-1/physiologyKWDmonocytes/microbiologyKWDmycobacteriumtuberculosis/physiologyKWDt-lymphocytes/virologyKWDvirusreplication/physiology
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M9791325

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