The neuropathology of HIV-infected African children in Abidjan, Cote d'Ivoire. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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The neuropathology of HIV-infected African children in Abidjan, Cote d'Ivoire.

J Neuropathol Exp Neurol. 1997 Jun;56(6):686-92. Unique Identifier : AIDSLINE MED/97328101
Bell JE; Lowrie S; Koffi K; Honde M; Andoh J; De Cock KM; Lucas SB; Department of Neuropathology, University of Edinburgh, Western General; Hospital.

Abstract: In an autopsy study of HIV-infected children in Abidjan, Cote d'Ivoire, the neuropathology of 76 HIV-1- and 2 HIV-2-positive children was compared with that of 77 frequency-matched HIV-negative children, in whom the systemic pathology was also known. Seventy of the 78 HIV-seropositive children were confirmed as HIV-infected, as determined by combined serology, IgA Western blots and clinicopathological criteria. The HIV-negative children showed a high background level (n = 49, 64%) of neuropathological abnormalities, including nonspecific inflammatory infiltrates, micromineralization, and bacterial and lymphocytic meningitis. In the HIV-positive children, HIV encephalitis was found in 4 (6%), cytomegalovirus in 2 (3%), toxoplasmosis in 3 (4%) and measles encephalitis in one (1%). Bacterial meningitis was equally common in both groups, but cerebral malaria was less common (n = 2, 3%) in HIV-positive than in HIV-negative children (n = 11, 14%). The low prevalence of HIV encephalitis may reflect comparatively early death in HIV infection in Africa as compared with our experience in Europe and the US.
Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS *Brain/PATHOLOGY *Central Nervous System Diseases/EPIDEMIOLOGY *HIV-1 *HIV-2KWDacquiredimmunodeficiencysyndrome/complicationsKWDbrain/pathologyKWDcentralnervoussystemdiseases/epidemiologyKWDhiv-1KWDhiv-2
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