Efficacy of paroxetine for the treatment of depression in the context of HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Efficacy of paroxetine for the treatment of depression in the context of HIV infection.

Pharmacopsychiatry. 1997 Mar;30(2):70-1. Unique Identifier : AIDSLINE MED/97278435
Grassi B; Gambini O; Garghentini G; Lazzarin A; Scarone S; Department of Neuropsychiatric Sciences, University of Milan Medical; School, Italy.

Abstract: Recent studies in the literature point out that HIV-infected subjects are affected by depression with a relatively high frequency. The aim of this study was to assess the efficacy and tolerability of paroxetine for the treatment of depression in the context of HIV infection. 15 HIV-infected subjects (10 patients with a major depressive episode and 5 patients with an adjustment disorder with depressed mood, according to the DSM IV diagnostic criteria) were administered paroxetine at a daily dosage of 20 mg. Depressive symptomatology was monitored by means of the Hamilton Rating Scale for Depression (HAM-D) at the time of enrollment and 2 weeks, 4 weeks, and 6 weeks later; at the same times adverse effects were recorded. 14 patients completed the study, and all of these recovered from depression; HAM-D mean scores significantly improved from baseline to final assessment, both when all subjects were considered (ANOVA for repeated measurements: p < or = 0.0001) and when only patients with a major depressive episode were included in the statistical analysis (ANOVA for repeated measurements: p < 0.0001). No significant adverse effects were recorded. Because of its efficacy and good tolerability paroxetine seems to be suitable for the treatment of depression in the context of HIV infection.
Keywords: *Antidepressive Agents, Second-Generation/THERAPEUTIC USE *Depression/DRUG THERAPY *HIV Infections/COMPLICATIONS *Paroxetine/THERAPEUTIC USEKWDantidepressiveagents,second-generation/therapeuticuseKWDdepression/drugtherapyKWDhivinfections/complicationsKWDparoxetine/therapeuticuse
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