An animal model for acute and persistent Epstein-Barr virus infection. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


An animal model for acute and persistent Epstein-Barr virus infection.

Science. 1997 Jun 27;276(5321):2030-3. Unique Identifier : AIDSLINE MED/97342848
Moghaddam A; Rosenzweig M; Lee-Parritz D; Annis B; Johnson RP; Wang F; Department of Medicine, Brigham and Women's Hospital, Harvard Medical; School, 181 Longwood Avenue, Boston, MA 02115, USA.

Abstract: Epstein-Barr virus (EBV) is a human lymphocryptovirus that causes infectious mononucleosis, persists asymptomatically for life in nearly all adults, and is associated with the development of B cell lymphomas and nasopharyngeal carcinomas. A highly similar rhesus lymphocryptovirus naturally endemic in rhesus monkeys was used to orally infect naive animals from a pathogen-free colony. This animal model reproduced key aspects of human EBV infection, including oral transmission, atypical lymphocytosis, lymphadenopathy, activation of CD23(+) peripheral blood B cells, sustained serologic responses to lytic and latent EBV antigens, latent infection in the peripheral blood, and virus persistence in oropharyngeal secretions. This system may be useful for studying the pathogenesis, prevention, and treatment of EBV infection and associated oncogenesis.
Keywords: *Disease Models, Animal *Herpesviridae Infections/IMMUNOLOGY *Herpesviridae Infections/PATHOLOGY *Herpesviridae Infections/VIROLOGY *Herpesvirus 4, Human *Lymphocryptovirus/IMMUNOLOGY *Lymphocryptovirus/ISOLATION & PURIF *Macaca mulatta *Tumor Virus Infections/IMMUNOLOGY *Tumor Virus Infections/PATHOLOGY *Tumor Virus Infections/VIROLOGYKWDdiseasemodels,animalKWDherpesviridaeinfections/immunologyKWDherpesviridaeinfections/pathologyKWDherpesviridaeinfections/virologyKWDherpesvirus4,humanKWDlymphocryptovirus/immunologyKWDlymphocryptovirus/isolation&purifKWDmacacamulattaKWDtumorvirusinfections/immunologyKWDtumorvirusinfections/pathologyKWDtumorvirusinfections/virology
970930
M9790650

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1997. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1997. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .