1997

Reframing women's risk: social inequalities and HIV infection.: Annu Rev Public Health. 1997;18:401-36. Unique Identifier : AIDSLINE MED/97288774; Zierler S; Krieger N; Department of Community Health, Brown University School of Medicine,; Providence, Rhode Island 02912, USA. sally_zierler@brown.edu; Social inequalities lie at the heart of risk of HIV infection among women in the United States . As of December, 1995, 71,818 US women had developed AIDS-defining diagnoses. These women have been disproportionately poor, African-American, and Latina. Their neighborhoods have been burden
Down-regulation of cell-surface CD4 co-receptor expression and modulation of experimental allergic encephalomyelitis.: Int Immunol. 1997 Apr;9(4):541-5. Unique Identifier : AIDSLINE MED/97283938; Fiori P; Ristori G; Cacciani A; Buttinelli C; Falcone M; Giovanni SD; Montesperelli C; Pozzilli C; Salvetti M; Department of Neurological Sciences, University of Rome La Sapienza,; Italy.; Pre-immunization with autoantigens confers resistance in experimental models of autoimmune diseases. Since non-self molecules can also be protective, it is conceivable that part of the effect rests on a non-specific attenuation of the immune response. This study is aimed at identifying mechanisms by which pre-immuniza
The use of CD4 and CD8 knockout mice to study the role of T-cell subsets in allotransplant rejection.: J Heart Lung Transplant. 1997 Mar;16(3):263-7. Unique Identifier : AIDSLINE MED/97242888; Krieger NR; Fathman CG; Department of Medicine, Stanford University School of Medicine, Calif.; 94305-5111, USA.
[Pentoxifylline and oral aphthosis in patients with HIV infection letter)]: An Med Interna. 1997 Feb;14(2):102. Unique Identifier : AIDSLINE MED/97269434; Blanch Falp J; Garcia Pont X; Torne Cachot J; Moner Coromina L; Baucells Azcona JM
[Home care for the terminally ill HIV patient]: An Med Interna. 1997 Feb;14(2):93-7. Unique Identifier : AIDSLINE MED/97269431; Bascunana Morejon de Giron J; Sanz de Barros R; de la Pena Gonzalez M; Candel Monserrate I; Servicio de Medicina Interna II, Hospital Universitario San Carlos,; Madrid.; Until now, the care of HIV patients, essentially were in the hospital; but the increase in the number of this and the news aspects of them have conditioned changes in the form of assistance. The primary assistance of this patients include prevention, precocious diagnostics, control of assymptomatics patients and diagn
Neurologic manifestations in human immunodeficiency virus infection/acquired immunodeficiency syndrome [editorial; comment]: Intern Med. 1997 Mar;36(3):160-1. Unique Identifier : AIDSLINE MED/97289081; Kimura S
Serum levels of soluble Fas/APO-1 receptor in human retroviral infection and associated diseases.: Intern Med. 1997 Mar;36(3):166-70. Unique Identifier : AIDSLINE MED/97289083; Kamihira S; Yamada Y; Hiragata Y; Yamaguchi T; Izumikawa K; Matsuo Y; Sugahara K; Tsuruta K; Atogami S; Tsukasaki K; Maeda T; Tomonaga M; Department of Laboratory Medicine, Nagasaki University School of; Medicine.; Fas/APO-1 mediates apoptosis via Fas and Fas ligand transduction. Recently, a soluble form of Fas (sFas) was described which seems to be functionally implicated in the Fas signal system, suggesting a relationship between some disorders and sFas function. We measured sFas-levels in sera from normal controls and patient
Nationwide survey of neurologic manifestations of acquired immunodeficiency syndrome in Japan [see comments]: Intern Med. 1997 Mar;36(3):175-8. Unique Identifier : AIDSLINE MED/97289085; Nakagawa M; Maruyama Y; Sugita H; Osame M; Third Department of Internal Medicine, Kagoshima University School of; Medicine.; To study the epidemiology of the neurologic manifestations of human immunodeficiency virus (HIV)-1 infection in Japan , we conducted two nationwide surveys. Of 1854 HIV-1 carriers, 578 had acquired immunodeficiency syndrome (AIDS) and 166 (28.7% of AIDS patients) had neurologic manif
[HIV and pregnancy: risks of transmission and therapeutic possibilities]: Gynakol Geburtshilfliche Rundsch. 1996;36(4):188-93. Unique Identifier : AIDSLINE MED/97290259; Ibe M; Knolle P; Beck T; Meyer zum Buschenfelde KH; Gerken G; Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universitat; Mainz, Deutschland.; In Europe, transmission of HIV-1 during pregnancy occurs in 14% of children born to HIV-infected women. Risk factors for transmission are (1) virus load measured by p-24 antigenemia and HIV RNA level, (2) low CD4+ lymphocyte counts (below 600/microliter, (3) placental membrane inflammation and (4) time interval betwee
Microbiologic and histologic diagnosis of histoplasmosis in Taiwan.: J Formos Med Assoc. 1997 May;96(5):374-8. Unique Identifier : AIDSLINE MED/97314568; Kao TW; Hung CC; Hsueh PR; Lin TY; Chen MY; Luh KT; Chuang CY; Department of Internal Medicine, National Taiwan University Hospital,; Taipei, ROC.; Histoplasmosis is one of the most common opportunistic fungal infections in immunocompromised patients in endemic areas. We report the first two microbiologically documented cases of histoplasmosis in Taiwan . The first patient, with
India protects jobs of people with HIV infection [news]: BMJ. 1997 May 24;314(7093):1505. Unique Identifier : AIDSLINE MED/97326373; Mudur G
A pilot HIV prevention program for adolescents in a psychiatric hospital.: Psychiatr Serv. 1997 Apr;48(4):531-3. Unique Identifier : AIDSLINE MED/97246129; Brown LK; Reynolds LA; Lourie KJ; Rhode Island Hospital, Providence 02903, USA.; In a pilot HIV prevention program for 35 adolescents in a psychiatric hospital, patients completed assessments of their HIV-related knowledge, attitudes, and behaviors before entering the program, at discharge, and three months after discharge. At discharge they showed significant increases in knowledge, tolerance of
Issues in the psychiatric care of Hispanics.: Psychiatr Serv. 1997 Apr;48(4):539-40. Unique Identifier : AIDSLINE MED/97246132; Ruiz P; Department of Psychiatry and Behavioral Sciences, University of; Texas-Houston Helath Science Center, USA.; Factors affecting the mental health care of ethnic minority groups in the United States deserve serious consideration. Hispanics, the second largest of these groups, face problems of access to care, high rates of substance abuse and HIV, and shortages of Hispanic psychiatric profession
[Role of the conformation changement of CD4 in the HIV-cell fusion]: C R Acad Sci III. 1997 Feb;320(2):163-70. Unique Identifier : AIDSLINE MED/97325053; Sanejouand YH; Laboratoire de physique quantique, UMR 5626 du CNRS, IRSAMC,; Universite Paul-Sabatier, Toulouse, France.; It is well known that the gp120-gp41 complex undergoes a conformational change after CD4 binding. It is likely that CD4 undergoes a conformational change as well. Recently, a calculation of the normal modes of the two N-terminal domains of CD4 has shown that a hinge-bending motion of one of these domains with respect
[New strategy for RNA vectorization in mammalian cells. Use of a peptide vector]: C R Acad Sci III. 1997 Apr;320(4):279-87. Unique Identifier : AIDSLINE MED/97326612; Vidal P; Morris MC; Chaloin L; Heitz F; Divita G; Centre de recherches de biochimie macromoleculaire, URS 155 CNRS,; Montpellier, France.; A major barrier for gene delivery is the low permeability of nucleic acids to cellular membranes. The development of antisenses and gene therapy has focused mainly on improving methods of oligonucleotide or gene delivery to the cell. In this report we described a new strategy for RNA cell delivery, based on a short si
National survey of endodontists and selected patient samples: infectious diseases and attitudes toward infection control.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jun;83(6):696-702. Unique Identifier : AIDSLINE MED/97339066; Cohen AS; Jacobsen EL; BeGole EA; University of the Pacific, School of Dentistry, San Francisco, Calif.,; USA.; A survey was conducted of 591 patients from endodontic practices located in six large municipalities in the United States . A comparison was made between the self-reported incidence of transmissible diseases from patients medical histories to national statistics for the incidence of hep
Leishmania and human immunodeficiency virus coinfection: the first 10 years.: Clin Microbiol Rev. 1997 Apr;10(2):298-319. Unique Identifier : AIDSLINE MED/97259656; Alvar J; Canavate C; Gutierrez-Solar B; Jimenez M; Laguna F; Lopez-Velez R; Molina R; Moreno J; Laboratorio de Referencia de Leishmaniasis, Instituto de Salud Carlos; III, Majadahonda, Madrid, Spain.; Over 850 Leishmania-human immunodeficiency virus (HIV) coinfection cases have been recorded, the majority in Europe, where 7 to 17% of HIV-positive individuals with fever have amastigotes, suggesting that Leishmania-infected individuals without symptoms will express symptoms of leishmaniasis if they become immunosuppr
Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection.: Clin Microbiol Rev. 1997 Apr;10(2):358-67. Unique Identifier : AIDSLINE MED/97259659; Weissman D; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-1576, USA. dweissman@nih.gov; The role of dendritic cells (DC) in the pathogenesis of human immunodeficiency virus (HIV) disease has been a subject of considerable interest for several years. Initial studies focused on the infection, dysfunction, and depletion of DC in HIV-infected individuals. More recent studies have begun to identify the functi
Markedly induced asialoGM1+CD8+ T cell production and enhancement of antimetastatic activity by interferon beta with folic or folinic acid.: Cancer Immunol Immunother. 1997 Apr;44(2):65-9. Unique Identifier : AIDSLINE MED/97320615; Iigo M; Moriyama M; Suzuki I; Tsuda H; Chemotherapy Division, National Cancer Center Research Institute,; Chuo-ku, Tokyo, Japan.; Either folic or folinic acid enhanced the antimetastatic activity of recombinant murine interferon beta (rMulFN beta) toward highly metastatic colon carcinoma 26 (Co 26Lu). Folinic acid administered with rMuIFN beta markedly increased asialoGM1+CD4+ and asialoGM1+CD8+ T cell production in the peritoneal cavity but not
Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment.: Cancer Immunol Immunother. 1997 Apr;44(2):77-82. Unique Identifier : AIDSLINE MED/97320617; Belfrage H; Dohlsten M; Hedlund G; Kalland T; Department of Cell and Molecular Biology, Lund University, Sweden.; Injection of the superantigen staphylococcal enterotoxin A (SEA) activates both CD4+ and CD8+ T cells expressing certain families of T cell receptor (TCR) variable-region beta (V beta) chain. T cells respond with profound cytokine production and induction of cytotoxicity. Repeated injections, however, cause deletion a
Cellular characteristics of peripheral blood lymphocytes and tumour-infiltrating lymphocytes in patients with gynaecological tumours.: Cancer Immunol Immunother. 1997 Apr;44(2):88-96. Unique Identifier : AIDSLINE MED/97320619; Schondorf T; Engel H; Lindemann C; Kolhagen H; von Rucker AA; Mallmann P; Department of Gynaecology and Obstetrics, University of Cologne,; Germany.; Immunotherapy of gynaecological cancer with tumour-infiltrating lymphocytes (TIL) or peripheral blood lymphocytes (PBL) has become a valid treatment modality with varying degrees of success in obtaining an antitumour response. TIL consist of lymphocytes, mainly T cells and minor populations of natural killer cells or
Treatment of subcutaneous tumor with adoptively transferred T cells.: Cell Immunol. 1997 May 25;178(1):24-32. Unique Identifier : AIDSLINE MED/97328137; Peng L; Shu S; Krauss JC; Center for Surgery Research, Cleveland Clinic Foundation, Ohio 44195,; USA.; Adoptive immunotherapy with T cells directed at tumor antigens has been demonstrated to result in the regression of malignant tumors in humans. These encouraging results have prompted the further exploration of parameters necessary to treat tumor in various locations in animal models. We have demonstrated that T cells
Inductive events in oral tolerance in the TCR transgenic adoptive transfer model.: Cell Immunol. 1997 May 25;178(1):62-8. Unique Identifier : AIDSLINE MED/97328141; Chen Y; Inobe J; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard; Medical School, Boston, Massachusetts 02115, USA.; Oral administration of antigen induces a systemic hyporesponsiveness termed oral tolerance. High doses of oral antigen lead to deletion or anergy of T-cells whereas low doses induce regulatory T-cells that secrete Th2 cytokines (IL-4/IL-10) and TGF-beta. The initiating events associated with oral tolerance have not be
Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis.: Cell Immunol. 1997 May 25;178(1):69-78. Unique Identifier : AIDSLINE MED/97328142; Xu H; Rizzo LV; Silver PB; Caspi RR; Laboratory of Immunology, NEI, National Institutes of Health,; Bethesda, Maryland 20892, USA.; This study addresses the nature of the pathogenic effector T cell in experimental autoimmune uveoretinitis and the effect of different cytokines on these cells in vitro. Lymph node cells of B10.RIII mice immunized with the uveitogenic peptide 161-180 of interphotoreceptor retinoid binding protein were cultured with th
Circulating CD8 T cells show increased interferon-gamma mRNA expression in HIV infection.: Cell Immunol. 1997 May 25;178(1):91-8. Unique Identifier : AIDSLINE MED/97328144; Breen EC; Salazar-Gonzalez JF; Shen LP; Kolberg JA; Urdea MS; Martinez-Maza O; Fahey JL; Department of Microbiology and Immunology, University of California,; Los Angeles 90095-1747, USA. ebreen@ucla.edu; IFN-gamma mRNA levels were measured in unstimulated PBMC and purified cell subpopulations, utilizing branched DNA assays, to characterize the cell type(s) that contribute to the in vivo increase in IFN-gamma gene expression seen in HIV infection. PBMC and CD8 T cells from HIV-seropositive subjects (HIV+) showed 2.5-fo
Solution conformation of N-terminal fragments of trichosanthin small domain (TCS 182-200). Circular dichroic studies.: J Pept Res. 1997 Feb;49(2):113-9. Unique Identifier : AIDSLINE MED/97292797; Hu HY; Lu ZX; Du YC; Shanghai Institute of Biochemistry, Chinese Academy of Sciences,; People's Republic of China.; Three peptides, T14, T18 and TDK, derived from the N-terminus of trichosanthin small domain (TCS 182-200) have been investigated by circular dichroism. Secondary structure and structural transitions of the above peptides under different conditions were studied. Alcohol prompts a transition of the T18 peptide from a be
Predicting RNA structures: the model of the RNA element binding Rev meets the NMR structure.: Fold Des. 1997;2(2):141-7. Unique Identifier : AIDSLINE MED/97281679; Leclerc F; Srinivasan J; Cedergren R; Departement de biochimie, Universite de Montreal CP, Quebec, Canada.; BACKGROUND: How accurate are the predictions of RNA three-dimensional structures? Assessing this accuracy requires the detailed comparison of the prediction with the experimentally determined structure. Previously, sequence variation in RNA aptamers that bind the Rev protein was used to infer a three-dimensional model
[Possible HIV infection: when exposure prophylaxis? (news)]: Dtsch Med Wochenschr. 1997 May 16;122(20):A7. Unique Identifier : AIDSLINE MED/97329763; Weismann H
Antifungal agents in the 1990s. Current status and future developments.: Drugs. 1997 Apr;53(4):539-49. Unique Identifier : AIDSLINE MED/97253215; Kauffman CA; Carver PL; Department of Internal Medicine, University of Michigan Medical; School, Ann Arbor, USA. ckauff@umich.edu; Significant advances in antifungal therapy have occurred in the last decade. Most of these advances have been tied to the introduction of the triazoles, itraconazole and fluconazole. Itraconazole has proved efficacious for the treatment of subacute to chronic infections with the endemic mycoses and other opportunistic
Lamivudine. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection.: Drugs. 1997 Apr;53(4):657-80. Unique Identifier : AIDSLINE MED/97253222; Perry CM; Faulds D; Adis International Limited, Auckland, New Zealand.; Lamivudine is a dideoxynucleoside analogue which undergoes intracellular phosphorylation to the putative active metabolite, lamivudine triphosphate. Lamivudine triphosphate prevents HIV replication by competitively inhibiting viral reverse transcripta
mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.: EMBO J. 1997 Apr 15;16(8):2054-60. Unique Identifier : AIDSLINE MED/97299882; Hilfiker A; Hilfiker-Kleiner D; Pannuti A; Lucchesi JC; Department of Biology and Graduate Program in Genetics and Molecular; Biology, Emory University, Atlanta, GA 30322, USA.; Dosage compensation is a regulatory process that insures that males and females have equal amounts of X-chromosome gene products. In Drosophila, this is achieved by a 2-fold enhancement of X-linked gene transcription in males, relative to females. The enhancement of transcription is mediated by the activity of a group
Human ribosomal protein L7 binds RNA with an alpha-helical arginine-rich and lysine-rich domain.: Eur J Biochem. 1997 May 1;245(3):549-56. Unique Identifier : AIDSLINE MED/97325977; Hemmerich P; Bosbach S; von Mikecz A; Krawinkel U; Universitat Konstanz, Lehrstuhl fur Immunologie, Germany.; In this study we mapped the RNA-binding domain of human ribosomal protein L7 and characterized its conformation-dependent RNA-binding specificity. Binding competition assays demonstrated preferential binding of L7 to mRNAs and rRNA, but not to tRNA. The ribohomopolymer poly(G) is bound with high affinity whereas poly(
Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution.: Eur J Biochem. 1997 May 1;245(3):581-8. Unique Identifier : AIDSLINE MED/97325981; Willbold D; Hoffmann S; Rosch P; Lehrstuhl fur Biopolymere, Universitat Bayreuth, Germany.; Dieter.Willbold@uni-bayreuth.de; The human immunodeficiency virus type 1 Vpu protein enhances virus particle release from infected cells, decreases the tendency of syncytia formation and induces degradation of human CD4 receptor. It is known that the cytoplasmic part of Vpu is responsible for direct interaction to and degradation of CD4. The tertiary
Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects.: Eur J Immunol. 1997 May;27(5):1131-9. Unique Identifier : AIDSLINE MED/97317589; Bellinghausen I; Metz G; Enk AH; Christmann S; Knop J; Saloga J; Department of Dermatology, University of Mainz, Germany.; The current study was carried out to elucidate the immunoregulatory changes induced by venom immunotherapy (VIT) in bee or wasp allergic subjects. All subjects included in this study had a history of severe systemic allergic reactions to stings of the respective insect as well as positive skin tests with the respectiv
Effect of interleukin-10 on dendritic cell maturation and function.: Eur J Immunol. 1997 May;27(5):1229-35. Unique Identifier : AIDSLINE MED/97317602; De Smedt T; Van Mechelen M; De Becker G; Urbain J; Leo O; Moser M; Departement de Biologie Moleculaire, Universite Libre de Bruxelles,; Rhode-Saint-Genese, Belgium.; The main function of dendritic cells (DC) is to induce the differentiation of naive T lymphocytes into helper cells producing a large array of lymphokines, including interleukin IL)-2; interferon-gamma (IFN-gamma), IL-4, IL-5 and IL-10. The potent immunostimulatory properties of DC develop during a process of maturati
Survival after AIDS diagnosis in Tuscany (Italy), 1985-1992.: Eur J Epidemiol. 1997 Feb;13(2):125-32. Unique Identifier : AIDSLINE MED/97239331; Barchielli A; Acciai S; Lazzeri V; Buiatti E; Epidemiology Unit, Center for Study and Prevention of Cancer,; Florence, Italy.; The study evaluated the overall survival after AIDS diagnosis of 1,014 patients reported to the Italian AIDS Registry as resident in Tuscany, stratified by age, gender, year of diagnosis, HIV transmission category, initial AIDS-defining disease and CD4+ cells count. The study was a population-based survival analysis,
MHC-dependent cytolysis of autologous tumor cells by lymphocytes infiltrating urothelial carcinomas.: Int J Cancer. 1997 May 16;71(4):585-94. Unique Identifier : AIDSLINE MED/97322158; Housseau F; Zeliszewski D; Roy M; Paradis V; Richon S; Ricour A; Bougaran J; Prapotnich D; Vallancien G; Benoit G; Desportes L; Bedossa P; Hercend T; Bidart JM; Bellet D; Laboratory of Tumor Immunology, URA 1484 CNRS, University of Rene; Descartes, Paris, France.; Tumor-infiltrating lymphocytes (TIL) were grown from 23 urothelial carcinomas. Phenotyping analysis showed that the TIL cultures were mainly CD3+. Although CD4+ and CD8+ T-cell sub-sets were grown in culture, CD4+ T-cell sub-sets predominated over CD8+ T cells. Immunohistochemical studies performed on 5 tumor specimen
Are cancers of the salivary gland increasing? Experience from Connecticut, USA.: Int J Epidemiol. 1997 Apr;26(2):264-71. Unique Identifier : AIDSLINE MED/97312719; Zheng T; Holford TR; Chen Y; Ward B; Liu W; Flannery J; Boyle P; Yale School of Medicine, Yale Cancer Center, New Haven, CT 06520-8034,; USA.; BACKGROUND: Recent studies indicate that cancers of the salivary gland are increasing, and the factors responsible for the increase are unknown. Artefactual changes, such as shift in classifying cancers of the floor of the mouth to cancers of the salivary gland, could affect the time trend for salivary gland cancer. M
Survival of AIDS patients according to type of AIDS-defining event. The AIDS in Europe Study Group.: Int J Epidemiol. 1997 Apr;26(2):400-7. Unique Identifier : AIDSLINE MED/97312736; Mocroft AJ; Lundgren JD; d'Armino Monforte A; Ledergerber B; Barton SE; Vella S; Katlama C; Gerstoft J; Pedersen C; Phillips AN; Dept Primary Care and Population Sciences, Royal Free Hospital School; of Medicine, London, UK.; BACKGROUND: There are known to be wide differences in the prognosis of patients with a diagnosis of AIDS. In this study of 6578 patients with AIDS form 17 European centres, we develop a ranking of AIDS-defining illnesses, and determine how well this ranking holds after adjustment for potential confounding variables. M
HIV-related risk factors of blood donors in northern Thailand before and after knowing HIV test results.: Int J Epidemiol. 1997 Apr;26(2):408-13. Unique Identifier : AIDSLINE MED/97312737; Sawanpanyalert P; Uthaivoravit W; Yanai H; Limpakarnjanarat K; Mastro TD; Nelson KE; Department of Medical Services, Ministry of Public Health, Muang; Nonthaburi, Thailand.; BACKGROUND: The epidemic of Human Immunodeficiency Virus (HIV) infection led blood banks to initiate donation deferral criteria based on self-reported risk factors. However little information is available on the differences in reporting risk factors before and after HIV status is known. METHODS: Between April and July
HIV infection and sexual behaviour among women with infertility in Tanzania: a hospital-based study.: Int J Epidemiol. 1997 Apr;26(2):414-9. Unique Identifier : AIDSLINE MED/97312738; Favot I; Ngalula J; Mgalla Z; Klokke AH; Gumodoka B; Boerma JT; Bugando Medical Centre, Mwanza, Tanzania.; BACKGROUND: Infertility is common in Africa, but virtually no data exist on HIV prevalence among infertile women. Mainly anthropological studies in Africa have shown that infertile women have higher risks of marital instability and possibly also have more sexual partners than fertile women. METHOD: This study was cond
[Th1 cells, Th2 cells and atopic dermatitis]: Hautarzt. 1997 Apr;48(4):223-7. Unique Identifier : AIDSLINE MED/97295467; Bohm I; Bauer R; Universitats-Hautklinik, Rheinischen Friedrich-Wilhelms-Universitat; Bonn.; The immunological hallmark of atopic dermatitis (AD) is a Th1/Th2 dysbalance. The reaction to high molecular weight environmental allergens (e.g. pollen, house dust mites), production of IgE and activation of eosinophil granulocytes result from Th2 dominance. The Th2-cytokine interleukin-4 (IL-4) is necessary for IgE
[Kaposi sarcoma in cyclosporin A therapy of actinic reticuloid]: Hautarzt. 1997 Apr;48(4):262-5. Unique Identifier : AIDSLINE MED/97295475; Waldmann V; Kempf W; Burg G; Dummer R; Dermatologische Klinik, Universitatsspital Zurich.; A 76 year old patient with actinic reticuloid was treated with Cyclosporin A. 11 months after beginning the immunosuppressive therapy, he developed lymphoedema and livid nodular skin lesions of the right leg, which histologically showed Kaposi s sarcoma. After stopping the Cyclosporin A and intralesional therapy with
[T-helper cells: the key to the pathogenesis of psoriasis?]: Hautarzt. 1997 Apr;48(4):291. Unique Identifier : AIDSLINE MED/97295481
Fusion peptides derived from the HIV type 1 glycoprotein 41 associate within phospholipid membranes and inhibit cell-cell Fusion. Structure-function study.: J Biol Chem. 1997 May 23;272(21):13496-505. Unique Identifier : AIDSLINE MED/97298046; Kliger Y; Aharoni A; Rapaport D; Jones P; Blumenthal R; Shai Y; Department of Membrane Research and Biophysics, Weizmann Institute of; Science, Rehovot, 76100 Israel.; The fusion domain of human immunodeficiency virus (HIV-1) envelope glycoprotein (gp120-gp41) is a conserved hydrophobic region located at the N terminus of the transmembrane glycoprotein (gp41). A V2E mutant has been shown to dominantly interfere with wild-type envelope-mediated syncytium formation and virus infectivi
Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation.: J Biol Chem. 1997 May 23;272(21):13779-85. Unique Identifier : AIDSLINE MED/97298085; Liu LX; Margottin F; Le Gall S; Schwartz O; Selig L; Benarous R; Benichou S; Institut Cochin de Genetique Moleculaire, INSERM U332, Universite; Paris V, 24 Rue du Faubourg Saint-Jacques, 75014 Paris, France.; Nef is a 27-kDa myristoylated protein conserved in primate lentiviruses. In vivo, simian immunodeficiency virus Nef is required in macaques to produce a high viral load and full pathological effects. Nef has at least three major effects in vitro, induction of CD4 down-regulation, alteration of T cell activation pathwa
Perspectives series: host/pathogen interactions. Dynamics of HIV-1 replication in vivo.: J Clin Invest. 1997 Jun 1;99(11):2565-7. Unique Identifier : AIDSLINE MED/97313490; Ho DD; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York 10016, USA. dho@adarc.org
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.: J Clin Invest. 1997 Jun 1;99(11):2752-61. Unique Identifier : AIDSLINE MED/97313512; Gupta S; Pablo AM; Jiang Xc; Wang N; Tall AR; Schindler C; Department of Medicine, Columbia University, New York 10032, USA.; The early colocalization of T cells and the potent immunostimulatory cytokine IFN-gamma to atherosclerotic lesions suggest that the immune system contributes to atherogenesis. Since mice with a targeted disruption of the apoE gene (apoE 0 mice) develop profound atherosclerosis, we examined the role of IFN-gamma in thi
Support group membership and perceptions of control over health in HIV+ men.: J Clin Psychol. 1997 Apr;53(3):249-52. Unique Identifier : AIDSLINE MED/97229056; Fontaine KR; McKenna L; Cheskin LJ; Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.; krf@welchlink.welch.jhu.edu; We compared health-related control perceptions in 115 HIV+ gay/ bisexual British men who were or were not members of an AIDS support group. Participants completed the Multidimensional Health Locus of Control Scale (MHLC). Compared to those who were not members of a support group, HIV+ men who belonged to a support gro
A case of adult T-cell leukemia/lymphoma (ATLL) with angiocentric and angiodestructive features.: J Dermatol. 1997 Mar;24(3):165-9. Unique Identifier : AIDSLINE MED/97269557; Ohtake N; Setoyama M; Fukumaru S; Kanzaki T; Department of Dermatology, Kagoshima University Faculty of Medicine,; Japan.; This report describes a case of adult T-cell leukemia/lymphoma ATLL) with angiocentric and angiodestructive features. The patient was a 66-year-old Japanese woman who began developing widespread skin lesions ten months prior to admission. The diagnosis of ATLL was made on the basis of her having an antibody to human T
Decreased fat and nitrogen losses in patients with AIDS receiving medium-chain-triglyceride-enriched formula vs those receiving long-chain-triglyceride-containing formula.: J Am Diet Assoc. 1997 Jun;97(6):605-11. Unique Identifier : AIDSLINE MED/97326499; Craig GB; Darnell BE; Weinsier RL; Saag MS; Epps L; Mullins L; Lapidus WI; Ennis DM; Akrabawi SS; Cornwell PE; Sauberlich HE; Department of Nutrition Sciences, School of Health Related; Professions, University of Alabama at Birmingham 35294, USA.; OBJECTIVE: The purpose of this study was to compare two enteral formulas, differing only in fat source, for product acceptance, tolerance, and effect on fat malabsorption and nutritional status in subjects with acquired immune deficiency syndrome (AIDS). DESIGN: The double-blind, randomized 15-day trial was divided in
Spectrum of clinical and laboratory characteristics of HIV infection in northern India.: J Commun Dis. 1995 Sep;27(3):131-41. Unique Identifier : AIDSLINE MED/97306405; Giri TK; Pande I; Mishra NM; Kailash S; Uppal SS; Kumar A; Department of Medicine, All India Institute of Medical Sciences, New; Delhi.; To define the impact of HIV infection in India , the clinical and laboratory profile and the correlation of CD4 count to the likely opportunistic infection in a cohort of 134 HIV positive patients in Northern India was analysed. Majority of the patients, 72% and 67.8% (children and a
No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders.: J Invest Dermatol. 1997 Jun;108(6):920-2. Unique Identifier : AIDSLINE MED/97325810; Henghold WB 2nd; Purvis SF; Schaffer J; Giam CZ; Wood GS; Department of Dermatology, Case Western Reserve University, Cleveland,; Ohio, USA.; The recently discovered human virus known as Kaposi s sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 HHV-8) has been associated with body-cavity-based lymphomas in AIDS patients. It is most closely related to two other herpesviruses, the Epstein-Barr virus and herpesvirus saimiri, which are known to be a
Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions.: J Infect Dis. 1997 Jun;175(6):1324-32. Unique Identifier : AIDSLINE MED/97323974; Webster-Cyriaque J; Edwards RH; Quinlivan EB; Patton L; Wohl D; Raab-Traub N; Department of Microbiology and Immunology and Lineberger Cancer; Center, University of North Carolina at Chapel Hill, 27599-7295, USA.; The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi s sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymera
Diagnosis of perinatal human immunodeficiency virus infection by polymerase chain reaction and p24 antigen detection after immune complex dissociation in an urban community hospital.: J Infect Dis. 1997 Jun;175(6):1333-6. Unique Identifier : AIDSLINE MED/97323975; Nesheim S; Lee F; Kalish ML; Ou CY; Sawyer M; Clark S; Meadows L; Grimes V; Simonds RJ; Nahmias A; Department of Pediatrics, Emory University School of Medicine, and; Centers for Disease Control and Prevention, Atlanta, Georgia 30335,; USA.; Results of polymerase chain reaction (PCR) and p24 antigen detection after immune complex dissociation (p24-ICD) were compared with antibody results after 18 months of age for human immunodeficiency virus (HIV) diagnosis in 345 prospectively followed, perinatally exposed infants. Of 59 infected and 286 uninfected infa
Experimental perinatal transmission of human immunodeficiency virus type 1 by passage of infected T cells.: J Infect Dis. 1997 Jun;175(6):1337-43. Unique Identifier : AIDSLINE MED/97323976; Simpson RM; Hubbard BS; Zhao TM; Kindt TJ; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Diseases, National Institutes of Health Twinbrook Facility,; Rockville, Maryland 20852, USA.; Pediatric AIDS typically follows transmission of human immunodeficiency virus type 1 (HIV-1) from infected mothers to their offspring. The possibility that infected maternal-origin cells serve as a conveyance for mother-to-child HIV-1 transmission was investigated in a rabbit infection model. Administration of HIV-1-i
Additive or sequential nucleoside analogue therapy compared with continued zidovudine monotherapy in human immunodeficiency virus-infected patients with advanced disease does not prolong survival: an observational study.: J Infect Dis. 1997 Jun;175(6):1344-51. Unique Identifier : AIDSLINE MED/97323977; van Leeuwen R; Bonsel GJ; Reiss P; Danner SA; Lange JM; Academic Medical Center, University of Amsterdam, Department of; Medicine, Netherlands.; To study the effect of sequential or additive use of zalcitabine or didanosine on survival in 308 human immunodeficiency virus-infected patients with advanced disease treated with zidovudine, an observational study using time-dependent Cox proportional hazards models was done. Changing to sequential or additive therap
Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hosts.: J Infect Dis. 1997 Jun;175(6):1352-9. Unique Identifier : AIDSLINE MED/97323978; Michael NL; Brown AE; Voigt RF; Frankel SS; Mascola JR; Brothers KS; Louder M; Birx DL; Cassol SA; Division of Retrovirology, Walter Reed Army Institute of Research, and; Henry M. Jackson Foundation, Rockville, Maryland 20850, USA.; A patient is described who rapidly progressed from primary human immunodeficiency virus (HIV) type 1 infection to death without seroconversion but with consistently high plasma viremia. His asymptomatic sex partner had been HIV-1 seropositive for >8 years prior to transmission. Analysis of viral sequences from these s
Characterization of a polyclonal cytolytic T lymphocyte response to human immunodeficiency virus in persons without clinical progression.: J Infect Dis. 1997 Jun;175(6):1360-7. Unique Identifier : AIDSLINE MED/97323979; Lubaki NM; Ray SC; Dhruva B; Quinn TC; Siliciano RF; Bollinger RC; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; A total of 82 human immunodeficiency virus (HIV)-1-specific cytolytic T lymphocyte (CTL) clones were isolated and characterized from 5 HIV-infected subjects, utilizing multiple HLA class I alleles. B62-restricted, HIV-1 gag-specific CTL clones isolated from a single blood sample from 1 subject used four different Vbet
Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice.: J Infect Dis. 1997 Jun;175(6):1368-81. Unique Identifier : AIDSLINE MED/97323980; Limoges J; Persidsky Y; Bock P; Gendelman HE; Department of Pathology, and the Eppley Institute for Research in; Cancer and Allied Medicine, University of Nebraska Medical Center,; Omaha 68198-5215, USA.; Human immunodeficiency virus (HIV) dementia is a late complication of viral infection. Cognitive dysfunction revolves around the secretion of neurotoxins from immunologically competent virus-infected brain macrophages and microglia. Such macrophage neurotoxins are inflammatory fact
Iron overload alters innate and T helper cell responses to Candida albicans in mice.: J Infect Dis. 1997 Jun;175(6):1467-76. Unique Identifier : AIDSLINE MED/97323992; Mencacci A; Cenci E; Boelaert JR; Bucci P; Mosci P; Fe d'Ostiani C; Bistoni F; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; The effect of iron overload on susceptibility of mice to Candida albicans infection and on the type of T helper (Th) immunity elicited was investigated. Iron overload greatly increased susceptibility to disseminated infection with low-virulence C. albicans cells of exogenous origin. The candidacidal activity and the a
Cytomegalovirus monitoring by polymerase chain reaction of whole blood samples from patients undergoing autologous bone marrow or peripheral blood progenitor cell transplantation.: J Infect Dis. 1997 Jun;175(6):1490-3. Unique Identifier : AIDSLINE MED/97323995; Hebart H; Schroder A; Loffler J; Klingebiel T; Martin H; Wassmann B; Gerneth F; Rabenau H; Jahn G; Kanz L; Muller CA; Einsele H; Medizinische Universitatsklinik, Abteilung II, Kinderklinik, Institut; fur Medizinische Informationsverarbeitung, and Abteilung fur; Medizinische Virologie, Universitat Tubingen, Germany.; Sensitive screening for cytomegalovirus ( CMV ) by polymerase chain reaction (PCR) following autologous bone marrow or peripheral blood progenitor cell transplantation has not been evaluated. In a three-center study, 98 autogra
Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine. Sydney Primary HIV Infection Study Group.: J Infect Dis. 1997 Jun;175(6):1502-6. Unique Identifier : AIDSLINE MED/97323998; Imrie A; Beveridge A; Genn W; Vizzard J; Cooper DA; Centre for Immunology, St Vincent's Hospital, Grosvenor Clinic,; Woolhara, Australia.; Human immunodeficiency virus type 1 (HIV-1) resistant to the nonnucleoside reverse transcriptase inhibitor nevirapine and to the nucleoside analogue zidovudine was transmitted from a homosexual man to his sex partner. The virus source patient had comm
Decreased short-term production of tumor necrosis factor-alpha and interleukin-1beta in human immunodeficiency virus-seropositive subjects.: J Infect Dis. 1997 Jun;175(6):1507-10. Unique Identifier : AIDSLINE MED/97323999; Ullum H; Victor J; Katzenstein TL; Gerstoft J; Gotzsche PC; Bendtzen K; Skinhoj P; Pedersen BK; Department of Infectious Diseases and Institute for Inflammation; Research, Rhima Centre, Rigshospitalet, Copenhagen, Denmark.; Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta IL-1beta) were measured by ELISA in 4.5-h, lipopolysaccharide-stimulated whole blood cultures of 347 human immunodeficiency virus type 1-infected patients and 107 healthy seronegative controls. The production of TNF-alpha was decreased in both AIDS and non-
Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair.: J Infect Dis. 1997 Jun;175(6):1510-5. Unique Identifier : AIDSLINE MED/97324000; Wang B; Ge YC; Jozwiak R; Bolton W; Palasanthiran P; Ziegler J; Chang J; Xiang SH; Cunningham AL; Saksena NK; Centers for Virus Research, Westmead Institutes for Health Research,; Westmead Hospital, NSW, Sydney, Australia.; Molecular analyses were done for the V3 region quasispecies of human immunodeficiency virus type 1 (HIV-1) strains from plasma and peripheral blood mononuclear cells of the first HIV-1-infected long-term-nonprogressing mother-child pair whose members have survived for >13 years with stable CD4 T cell counts. There was
Infection of human monocytes with Mycobacterium tuberculosis enhances human immunodeficiency virus type 1 replication and transmission to T cells.: J Infect Dis. 1997 Jun;175(6):1531-5. Unique Identifier : AIDSLINE MED/97324005; Mancino G; Placido R; Bach S; Mariani F; Montesano C; Ercoli L; Zembala M; Colizzi V; Department of Biology, University of Rome Tor Vergata, Institute of; Experimental Medicine, National Research Council, Italy.; Mycobacterium tuberculosis and human immunodeficiency virus type 1 (HIV-1) are virulent intracellular pathogens that invade and multiply within macrophages. The effect of M. tuberculosis on HIV-1 infection and replication was analyzed in vitro using human monocyte-derived macrophages (MDM) isolated from peripheral blo
Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor NF)-kappaB.: J Exp Med. 1997 Jun 2;185(11):1897-907. Unique Identifier : AIDSLINE MED/97311088; Boothby MR; Mora AL; Scherer DC; Brockman JA; Ballard DW; Department of Microbiology and Immunology, Vanderbilt University; Medical Center, Nashville, Tennessee 37232, USA.; Members of the nuclear factor (NF)-kappaB/Rel family transcription factors are induced during thymic selection and in mature T lymphocytes after ligation of the T cell antigen receptor (TCR). Despite these findings, disruption of individual NF-kappaB/Rel genes has revealed no intrinsic defect in the development of mat
T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.: J Exp Med. 1997 Jun 2;185(11):1969-75. Unique Identifier : AIDSLINE MED/97311095; Sciammas R; Kodukula P; Tang Q; Hendricks RL; Bluestone JA; Ben May Institute for Cancer Research, Department of Pathology and; Committee on Immunology, University of Chicago, Chicago, Illinois; 60637, USA.; Increased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influenza and sendai virus infections, as well as in patients infected with human immunodeficiency virus and herpes simplex virus type 1 (HSV-1). However, a direct role for TCR-gamma/delta cells in protective immunity f
9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation.: J Exp Med. 1997 Jun 2;185(11):1997-2013. Unique Identifier : AIDSLINE MED/97311098; Krishna M; Varki A; Glycobiology Program, UCSD Cancer Center, the Department of Medicine,; University of California, San Diego, La Jolla, California 92093, USA.; Terminal sialic acids on cell surface glycoconjugates can carry 9-O-acetyl esters. For technical reasons, it has previously been difficult to determine their precise distribution on different cell types. Using a recombinant soluble form of the Influenza C virus hemagglutinin-esterase as a probe for 9-O-acetylated sial
STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.: J Exp Med. 1997 Jun 2;185(11):2015-23. Unique Identifier : AIDSLINE MED/97311099; Liao F; Alkhatib G; Peden KW; Sharma G; Berger EA; Farber JM; Laboratory of Clinical Investigation, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland, USA.; The chemokine receptors CXCR4, CCR2B, CCR3, and CCR5 have recently been shown to serve along with CD4 as coreceptors for HIV-1. The tropisms of HIV-1 strains for subgroups of CD4(+) cells can be explained, at least partly, by the selective use of G protein-coupled receptors (GPCRs). We have identified a novel human ge
Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology.: J Med Virol. 1997 May;52(1):1-7. Unique Identifier : AIDSLINE MED/97278116; Vandamme AM; Van Laethem K; Liu HF; Van Brussel M; Delaporte E; de Castro Costa CM; Fleischer C; Taylor G; Bertazzoni U; Desmyter J; Goubau P; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Belgium.; In countries with a low prevalence of human T-lymphotropic virus HTLV) infection, indeterminate HTLV serologies are a major problem in blood bank screening because of the uncertainties about infection in these cases. The recent discovery of two new types of simian T-lymphotropic viruses (STLV), which give an HTLV-inde
Comparison of HCV RNA assays for the detection and quantification of hepatitis C virus RNA levels in serum of patients with chronic hepatitis C treated with interferon.: J Med Virol. 1997 May;52(1):105-12. Unique Identifier : AIDSLINE MED/97278132; Trabaud MA; Bailly F; Si-Ahmed SN; Chevallier P; Sepetjan M; Colucci G; Trepo C; Unite de recherche sur les Virus des hepatites, (INSERM U271), Lyon,; France.; Detection and quantification of hepatitis C virus (HCV) RNA levels by using the standardized qualitative Amplicor HCV and quantitative Amplicor HCV Monitor assays (Roche Molecular Systems) were evaluated in 48 patients with chronic hepatitis C treated with interferon. Results were compared with an in-house reverse tra
Evaluation of the presence of 2-LTR HIV-1 unintegrated DNA as a simple molecular predictor of disease progression.: J Med Virol. 1997 May;52(1):20-5. Unique Identifier : AIDSLINE MED/97278119; Zazzi M; Romano L; Catucci M; Venturi G; De Milito A; Almi P; Gonnelli A; Rubino M; Occhini U; Valensin PE; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; In a preliminary cross-sectional analysis of 109 human immunodeficiency virus type 1 (HIV-1)-infected subjects the presence of 2-long terminal repeat (LTR) unintegrated circular HIV-1 DNA in peripheral blood mononuclear cells (PBMC) was found to be associated with both symptomatic infection (P = 0.0037) and low CD4 co
Phenotypic variations and switches in HIV isolated from the blood and the gastrointestinal tissues of patients with HIV-1 infection. HIV/GI Research Study Group.: J Med Virol. 1997 May;52(1):31-4. Unique Identifier : AIDSLINE MED/97278121; al-Mulla W; Church D; Gill MJ; Faculty of Medicine, Kuwait University, Kuwait.; The objective of this study was to determine the initial and subsequent phenotypes of HIV-1 isolated from the blood, duodenal, and colonic biopsies of 51 HIV-1 positive patients followed prospectively over 2 years. Blood and tissues were cocultured with stimulated peripheral blood monocytes, and HIV was analyzed for p
Common origin of human T-lymphotropic virus type-I from Iran, Kuwait, Israel, and La Reunion Island.: J Med Virol. 1997 May;52(1):77-82. Unique Identifier : AIDSLINE MED/97278127; Voevodin A; Gessain A; Department of Microbiology, Faculty of Medicine, Kuwait University,; Kuwait.; We found previously that Kuwaiti HTLV-I isolates had two nucleotide substitutions in the most frequently sequenced regions of HTLV-I genome, namely: T-->C 4783 in the pol and T-->C 6569 the env genes. These substitutions were observed rarely in other HTLV-I isolates and seemed to be good markers of the HTLV-I lineage,
Interleukin (IL)-1 beta and IL-1 beta mRNA expression in normal and diseased skeletal muscle assessed by immunocytochemistry, immunoblotting and reverse transcriptase-nested polymerase chain reaction.: J Neuropathol Exp Neurol. 1997 Jun;56(6):651-63. Unique Identifier : AIDSLINE MED/97328098; Belec L; Authier FJ; Chazaud B; Piedouillet C; Barlovatz-Meimon G; Gherardi RK; Groupe d'Etude et de Recherche sur le Nerf Et le Muscle, Faculte de; Medecine de Creteil-Paris XII, France.; To confirm the production of IL-1 beta and to optimize detection and semiquantitation of IL-1 beta mRNA by polymerase chain reaction (PCR) techniques in skeletal muscle tissue, immunocytochemistry, immunoblotting and several procedures of RNA extraction and reverse transcription (RT)-PCR amplification were used on mus
The neuropathology of HIV-infected African children in Abidjan, Cote d'Ivoire.: J Neuropathol Exp Neurol. 1997 Jun;56(6):686-92. Unique Identifier : AIDSLINE MED/97328101; Bell JE; Lowrie S; Koffi K; Honde M; Andoh J; De Cock KM; Lucas SB; Department of Neuropathology, University of Edinburgh, Western General; Hospital.; In an autopsy study of HIV-infected children in Abidjan, Cote d Ivoire , the neuropathology of 76 HIV-1- and 2 HIV-2-positive children was compared with that of 77 frequency-matched HIV-negative children, in whom the systemic pathology was also known. Seventy of the 78 HIV-sero
Zidovudine adherence in persons with AIDS. The relation of patient beliefs about medication to self-termination of therapy.: J Gen Intern Med. 1997 Apr;12(4):216-23. Unique Identifier : AIDSLINE MED/97272519; Smith MY; Rapkin BD; Morrison A; Kammerman S; Psychiatry Service, Memorial Sloan-Kettering Cancer Center, New York,; NY 10021, USA.; OBJECTIVE: To examine the relation of patient beliefs about medication usage and adherence to zidovudine (ZDV) therapy in persons with AIDS. DESIGN: Face-to-face interviews were used to determine attitudes of persons with AIDS toward ZDV and other prescribed medications, history of ZDV usage, and sociodemographics. SE
HIV-infected competitive athletes. What are the risks? What precautions should be taken?: J Gen Intern Med. 1997 Apr;12(4):243-6. Unique Identifier : AIDSLINE MED/97272523; Feller A; Flanigan TP; Graduate School of Biomedical Sciences, Bryn Mawr College, PA, USA.
Childhood sexual abuse among homosexual men. Prevalence and association with unsafe sex.: J Gen Intern Med. 1997 Apr;12(4):250-3. Unique Identifier : AIDSLINE MED/97272525; Lenderking WR; Wold C; Mayer KH; Goldstein R; Losina E; Seage GR 3rd; Department of Biostatistics, Harvard School of Public Health, Boston,; MA, USA.; Of 327 homosexual and bisexual men participating in an ongoing cohort study pertaining to risk factors for HIV infection who completed a survey regarding history of sexual abuse, 116 (35.5%) reported being sexually abused as children. Those abused were more likely to have more lifetime male partners, to report more ch
The utility of direct acid-fast stain of cerebrospinal fluid for the rapid diagnosis of tuberculous meningitis in patients with and without AIDS [letter]: J Gen Intern Med. 1997 Apr;12(4):259. Unique Identifier : AIDSLINE MED/97272530; Dural AT; Johnson PC; Wagner A
Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.: J Med Chem. 1997 May 23;40(11):1707-9. Unique Identifier : AIDSLINE MED/97315875; De Lucca GV; Liang J; Aldrich PE; Calabrese J; Cordova B; Klabe RM; Rayner MM; Chang CH; DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500,; USA.; Re-examination of the design of the cyclic urea class of HIV protease (HIVPR) inhibitors suggests a general approach to designing novel nonpeptide cyclic HIVPR inhibitors. This process involves the inversion of the stereochemical centers of the core transition-state isostere of the linear HIVPR inhibitors and cyclizat
HIV infection with Hodgkin's disease: the virus makes a difference [news]: J Natl Cancer Inst. 1997 Jun 4;89(11):754-5. Unique Identifier : AIDSLINE MED/97325956; McNeil C
[Analysis of T cell subsets with monoclonal antibodies]: Nippon Rinsho. 1997 Mar;55 Suppl 1:159-65. Unique Identifier : AIDSLINE MED/97251974; Homma T; Morimoto C; Department of Clinical Immunology, University of Tokyo Institute of; Medical Science.
Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines.: Leukemia. 1997 Jun;11(6):866-70. Unique Identifier : AIDSLINE MED/97320591; Cereseto A; Berneman Z; Koralnik I; Vaughn J; Franchini G; Klotman ME; Laboratory of Tumor Cell Biology, National Cancer Institute, National; Institutes of Health, Bethesda, MD, USA.; Human T cell leukemia/lymphotropic virus (HTLV) is a complex 9 kb human retrovirus with at least eight alternatively spliced mRNAs expressed from the 3 or pX region of the genome. These mRNAs allow for the expression of novel proteins from the previously recognized pX open reading frames I and II in addition to Tax,
Angioimmunoblastic lymphadenopathy with disseminated human herpesvirus 6 infection in a patient with acute myeloblastic leukemia.: Leukemia. 1997 Jun;11(6):882-5. Unique Identifier : AIDSLINE MED/97320593; Daibata M; Ido E; Murakami K; Kuzume T; Kubonishi I; Taguchi H; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.; A 47-year-old man with acute myeloblastic leukemia (AML) developed angioimmunoblastic lymphadenopathy with dysproteinemia AILD) 4 months after induction chemotherapy for AML. During a leukopenic period, the patient suffered from pericarditis with massive pericardial effusion in which human herpesvirus 6 (HHV-6) DNA wa
Histological improvement in patients with chronic hepatitis B virus infection treated with lamivudine.: Liver. 1997 Apr;17(2):103-6. Unique Identifier : AIDSLINE MED/97284205; Honkoop P; de Man RA; Zondervan PE; Schalm SW; Department of Internal Medicine II, (Section Hepatology), Erasmus; University Hospital, Rotterdam, The Netherlands.; Lamivudine is an oral nucleoside analogue with strong antiviral activity against hepatitis B virus (HBV). In previous clinical studies, a course of lamivudine for 4-12 weeks induced a profound decrease in HBV viraemia with excellent tolerance, but dat
[Primary lung Kaposi sarcoma associated to AIDS in a heterosexual drug addict man]: Medicina (B Aires). 1996;56(4):397-402. Unique Identifier : AIDSLINE MED/97284270; Troncoso AR; Carranza CM; Romani AH; Patini SE; Berasaluce G; Canataro PA; Masini R; Macias JR; Hospital de Enfermedades Infecciosas Francisco J. Muniz, Buenos Aires,; argentina.; A case of lung Kaposi sarcoma (KS) in the absence of cutaneomucosal lesions was observed in a 30-year-old heterosexual male with AIDS and a history of intravenous drug addiction. Both chest X-ray and CT scanning disclosed a diffuse nodular pattern in lungs, whereas endoscopy failed to demonstrate endobronchial damage.
Advantage of dimeric peptide antigens in serodiagnosis of HIV-1 infection.: Microbiol Immunol. 1997;41(3):215-20. Unique Identifier : AIDSLINE MED/97276480; Gokulan K; Tripathi SP; Rao DN; Department of Biochemistry, All India Institute of Medical Sciences,; New Delhi, India.; The reactivity of antibodies with dimeric and monomeric peptide antigens was compared by ELISA. A panel of highly purified synthetic peptides of HIV-1 representing defined regions, 598-609 and 524-533 (fusion domain) of gp41 and 306-320 of gp120, were used as antigens in the ELISA. These peptides were selected and syn
Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice.: Microbiol Immunol. 1997;41(3):221-7. Unique Identifier : AIDSLINE MED/97276481; Hiromatsu K; Usami J; Aoki Y; Makino M; Yoshikai Y; Laboratory of Host Defense, Nagoya University School of Medicine,; Aichi, Japan.; We reported previously that CD4+ T cells and B cells in mice with retrovirus-induced murine acquired immunodeficiency syndrome MAIDS) caused by LP-BM5 murine leukemia virus (MuLV) mixtures increased the expression of Fas antigen (Fas) during progression of the disease. However, the contribution of the Fas/Fas ligand F
Infection of an HIV-1/SIVmac chimeric virus having HIV-1 env to macaque monkeys via the vaginal cavity.: Microbiol Immunol. 1997;41(3):277-80. Unique Identifier : AIDSLINE MED/97276488; Ido E; Okada M; Enose Y; Kuwata T; Igarashi T; Sata T; Terao K; Chen J; Hayami M; Laboratory of Pathogenic Virus, University, Japan.; We previously reported that an HIV-1/SIVmac chimeric virus designated as NM-3rN) having HIV-1 env efficiently infected macaque monkeys by intravenous inoculation. In this study, this chimeric virus was atraumatically inoculated into the vaginal cavity of two rhesus and one cynomolgus monkeys. Although antibody respons
Human immunodeficiency virus type-1 envelope glycoprotein gp120 induces expression of fusion regulatory protein (FRP)-1/CD98 on CD4+ T cells: a possible regulatory mechanism of HIV-induced syncytium formation.: Med Microbiol Immunol (Berl). 1997 Mar;185(4):237-43. Unique Identifier : AIDSLINE MED/97284220; Suga S; Tsurudome M; Ito M; Ohgimoto S; Tabata N; Nishio M; Kawano M; Komada H; Ito M; Sakurai M; Ito Y; Department of Microbiology, Mie University School of Medicine, Japan.; Syncytium formation is one of major cytopathic effects of human immunodeficiency virus (HIV) infection, and requires the interaction of CD4 molecules on uninfected cells with HIV envelope glycoprotein gp120 expressed on HIV-infected cells. Recent evidence suggests chemokine receptors function as fusion cofactors. We h
Feline immunodeficiency virus causes increased glutamate levels and neuronal loss in brain.: Neuroscience. 1997 Apr;77(4):1175-85. Unique Identifier : AIDSLINE MED/97277103; Power C; Moench T; Peeling J; Kong PA; Langelier T; Department of Internal Medicine and Medical Microbiology, University; of Manitoba, Winnipeg, Canada.; Feline immunodeficiency virus, like human immunodeficiency virus type 1, is a retrolentivirus causing neurological disease and immune suppression. Primary neurological complications, including human immunodeficiency virus encephalopathy and peripheral neuropathy , and
Changes in total, CD4+, and CD8+ lymphocytes during pregnancy and 1 year postpartum in human immunodeficiency virus-infected women. The Women and Infants Transmission Study.: Obstet Gynecol. 1997 Jun;89(6):967-74. Unique Identifier : AIDSLINE MED/97314134; Tuomala RE; Kalish LA; Zorilla C; Fox H; Shearer W; Landay A; Vermund SH; Landesman S; Burns D; Department of Obstetrics and Gynecology, Brigham and Women's Hospital,; Boston, Massachusetts, USA.; OBJECTIVE: To assess changes in lymphocyte subsets during pregnancy and 1 year postpartum in human immunodeficiency virus HIV)-infected women. METHODS: Changes in CD4+ and CD8+ cell counts, CD4 and CD8 percent, CD4/CD8 ratio, and total lymphocyte count and percent were assessed in each of 226 HIV-infected women follow
Down-regulation of murine susceptibility to cerebral malaria by inoculation with third-stage larvae of the filarial nematode Brugia pahangi.: Parasitology. 1997 Apr;114 ( Pt 4):333-8. Unique Identifier : AIDSLINE MED/97260944; Yan Y; Inuo G; Akao N; Tsukidate S; Fujita K; Department of Medical Zoology, School of Medicine, Tokyo Medical and; Dental University, Tokyo, Japan.; In areas where malaria is endemic, helminthic infections, caused by intestinal or filarial parasites, commonly coexist with malaria in the same individual. This study investigates the course of Plasmodium berghei malaria infection in CBA/J mice inoculated with irradiated attenuated 3rd-stage larvae (L3) of Brugia paha
[A new gamma-2 herpesvirus, defined as HHV8 or Kaposi's sarcoma herpes virus (KSHV), could be involved in the pathogenesis of Kaposi's sarcoma]: Pathologica. 1996 Dec;88(6):525-6. Unique Identifier : AIDSLINE MED/97269681; Ruco LP
High resolution fast quantitative docking using Fourier domain correlation techniques.: Proteins. 1997 Apr;27(4):493-506. Unique Identifier : AIDSLINE MED/97285913; Blom NS; Sygusch J; Departement de Biochimie, Universite de Montreal, Quebec, Canada.; A docking method based on finite grid forcefield sampling is proposed for fast evaluation of interaction energies between macromolecules and ligands. Forcefield used to calculate interaction energies utilizes a potential energy function composed of a 1/r-dependent electrostatic term and a (6-12) Lennard-Jones term f
Efficacy of paroxetine for the treatment of depression in the context of HIV infection.: Pharmacopsychiatry. 1997 Mar;30(2):70-1. Unique Identifier : AIDSLINE MED/97278435; Grassi B; Gambini O; Garghentini G; Lazzarin A; Scarone S; Department of Neuropsychiatric Sciences, University of Milan Medical; School, Italy.; Recent studies in the literature point out that HIV-infected subjects are affected by depression with a relatively high frequency. The aim of this study was to assess the efficacy and tolerability of paroxetine for the treatment of depression in the context of HIV infection. 15 HIV-infected subjects (10 patients with
Prevalence and predictors of depressive, anxiety and substance use disorders in HIV-infected and uninfected men: a longitudinal evaluation.: Psychol Med. 1997 Mar;27(2):395-409. Unique Identifier : AIDSLINE MED/97245073; Dew MA; Becker JT; Sanchez J; Caldararo R; Lopez OL; Wess J; Dorst SK; Banks G; Department of Psychiatry, University of Pittsburgh School of Medicine,; PA 15213, USA.; BACKGROUND: There is little agreement on whether the prevalence of psychiatric disorder is elevated in HIV-seropositive (HIV+) populations compared with uninfected persons. However, evaluation of this issue has been limited difficulties of sampling, study design and failure to control for other risk factors for disord
Prevalence and trends in homosexual behaviour in Norway.: Scand J Soc Med. 1997 Mar;25(1):33-8. Unique Identifier : AIDSLINE MED/97260825; Veierod MB; Eskild A; Stigum H; Thorvaldsen J; Magnus P; Department of Epidemiology, National Institute of Public Health,; Ullev~al University Hospital, Oslo, Norway.; The three main objectives of this study were to estimate the proportion of the Norwegian population with experience of homosexual behaviour, to study the degree of change in sexual practices among homosexual men during a 5-year period and to study the degree of change in sexual practices reported by HIV positive homos
New clues to asthma therapies [news]: Science. 1997 Jun 13;276(5319):1643-6. Unique Identifier : AIDSLINE MED/97343854; Vogel G
Causing cancer by remote control? [news; comment]: Science. 1997 Jun 20;276(5320):1788-9. Unique Identifier : AIDSLINE MED/97345601; Gura T
Does a common virus give HIV a helping hand? [news; comment]: Science. 1997 Jun 20;276(5320):1794. Unique Identifier : AIDSLINE MED/97345602; Balter M
Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients [see comments]: Science. 1997 Jun 20;276(5320):1851-4. Unique Identifier : AIDSLINE MED/97334439; Rettig MB; Ma HJ; Vescio RA; Pold M; Schiller G; Belson D; Savage A; Nishikubo C; Wu C; Fraser J; Said JW; Berenson JR; Division of Hematology and Oncology, Veterans Affairs West Los Angeles; Medical Center, Los Angeles, CA 90073, USA.; RETTIG.MATTHEW@WEST-LA.VA.GOV; Kaposi s sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells fr
Macrophages as a source of HIV during opportunistic infections.: Science. 1997 Jun 20;276(5320):1857-61. Unique Identifier : AIDSLINE MED/97334441; Orenstein JM; Fox C; Wahl SM; Department of Pathology, George Washington University, Washington, DC; 20037, USA. jmo@gwis2.circ.gwu.edu; The source of increasing viremia that characterizes the latter stages of human immunodeficiency virus (HIV) disease has remained a paradox because it occurs at a time when lymphoid tissue is quantitatively and qualitatively impaired, and the patients CD4 T lymphocytes are steadily declining. Here, macrophages, both i
Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry [see comments]: Science. 1997 Jun 20;276(5320):1874-8. Unique Identifier : AIDSLINE MED/97334446; Pleskoff O; Treboute C; Brelot A; Heveker N; Seman M; Alizon M; Inserm U.332, Institut Cochin de Genetique Moleculaire, 22 rue; Mechain, 75014 Paris, France.; The human cytomegalovirus encodes a beta-chemokine receptor US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of C
The hierarchical diffusion of AIDS and violent crime among U.S. metropolitan regions: inner-city decay, stochastic resonance and reversal of the mortality transition.: Soc Sci Med. 1997 Apr;44(7):935-47. Unique Identifier : AIDSLINE MED/97245157; Wallace R; Huang YS; Gould P; Wallace D; PISCS Inc., New York, NY 10027, USA.; Census data on migration within and between the 25 largest U.S. metropolitan areas-containing more than 113 million people-permit construction of a probability-of-contact matrix corresponding to a particular Markov process dominated by the nation s largest cities, a hierarchical structure. Regression models based on v
[An unjustified fear]: Soins Psychiatr. 1996 Feb;(180):47-8. Unique Identifier : AIDSLINE MED/96334687; Dupuy C
Give Virodene and the Minister a break! [editorial]: S Afr Med J. 1997 Mar;87(3):253. Unique Identifier : AIDSLINE MED/97283199; Ncayiyana DJ
Rebel with a cause.: S Afr Med J. 1997 Mar;87(3):263-4. Unique Identifier : AIDSLINE MED/97283200; van der Linde I
Should South Africa be preparing for HIV-1 vaccine efficacy trials? [editorial]: S Afr Med J. 1997 Mar;87(3):285-90. Unique Identifier : AIDSLINE MED/97283204; Morris L; van der Ryst E; Gray C; Williamson C
Fine-needle aspiration of lymph nodes [letter; comment]: S Afr Med J. 1997 Mar;87(3):342, 344. Unique Identifier : AIDSLINE MED/97283219; Parrish AG
The enhancement of wound healing with human skin allograft.: Surg Clin North Am. 1997 Jun;77(3):731-45. Unique Identifier : AIDSLINE MED/97338329; Spence RJ; Wong L; Johns Hopkins Medical School, Baltimore, Maryland, USA.; Although clean incisional wounds can be closed easily, contaminated wounds, wounds with tissue loss that cannot be closed primarily, and chronic wounds are generally not closed and suffer the effects of being open. It follows that wound healing would be enhanced if these wounds could be closed. This article describes
Introduction: recent advances in the pathogenesis of human immunodeficiency virus infection.: Springer Semin Immunopathol. 1997;18(3):253-6. Unique Identifier : AIDSLINE MED/97245188; Pantaleo G; Fauci AS; Laboratory of AIDS Immunopathogenesis, Department of Medicine, Centre; Hospitalier Universitaire Vadois (CHUV), Lausanne, Switzerland.
Virologic and immunologic events in primary HIV infection.: Springer Semin Immunopathol. 1997;18(3):257-66. Unique Identifier : AIDSLINE MED/97245189; Pantaleo G; Graziosi C; Fauci AS; Laboratory of AIDS Immunopathogenesis, Department of Internal; Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne,; Switzerland.
The role of viral dynamics in the pathogenesis of HIV disease and implications for antiviral therapy.: Springer Semin Immunopathol. 1997;18(3):267-83. Unique Identifier : AIDSLINE MED/97245190; Havlir DV; Richman DD; Department of Medicine, University of California, San Diego, USA.
Immune dysregulation and CD4+ T cell loss in HIV-1 infection.: Springer Semin Immunopathol. 1997;18(3):285-303. Unique Identifier : AIDSLINE MED/97245191; Meyaard L; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam, The; Netherlands.
Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies.: Springer Semin Immunopathol. 1997;18(3):305-22. Unique Identifier : AIDSLINE MED/97245192; Cohen OJ; Pantaleo G; Lam GK; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1876, USA.; Lymphoid tissue is a major reservoir of human immunodeficiency virus (HIV) infection in vivo. In addition, the lymphoid microenvironment provides a replicative advantage to the virus in that it provides a milieu of activated target cells that allows for efficient virus spread. The process of mobilization and activatio
Mechanisms of resistance to HIV infection.: Springer Semin Immunopathol. 1997;18(3):323-40. Unique Identifier : AIDSLINE MED/97245193; Paxton WA; Koup RA; Aaron Diamond AIDS Research Center, New York, NY 10016, USA.
HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication.: Springer Semin Immunopathol. 1997;18(3):341-54. Unique Identifier : AIDSLINE MED/97245194; Jassoy C; Walker BD; Institute for Virology and Immunobiology, Julius-Maximilians; University, Wurzburg, Germany.
Noncytolytic CD8 T cell-mediated suppression of HIV replication.: Springer Semin Immunopathol. 1997;18(3):355-69. Unique Identifier : AIDSLINE MED/97245195; Greenberg ML; Lacey SF; Chen CH; Bolognesi DP; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham, NC; 27710, USA.
Role of complement and Fc receptors in the pathogenesis of HIV-1 infection.: Springer Semin Immunopathol. 1997;18(3):371-90. Unique Identifier : AIDSLINE MED/97245196; Montefiori DC; Department of Surgery, Duke University Medical Center, Durham, NC; 27710, USA.
Simian immunodeficiency virus as a model of HIV pathogenesis.: Springer Semin Immunopathol. 1997;18(3):391-405. Unique Identifier : AIDSLINE MED/97245197; Norley S; Kurth R; Paul-Ehrlich-Institute, Langen, Germany.
Radioimmunoassay of zidovudine: extended use and potential application.: Ther Drug Monit. 1997 Apr;19(2):195-200. Unique Identifier : AIDSLINE MED/97262267; DeRemer M; D'Ambrosio R; Bartos L; Cousins S; Morse GD; Department of Pharmacy Practice, State University of New York at; Buffalo 14260, USA.; When first approved, the dosing regimens for zidovudine were 1,200-1,500 mg/day; however, because toxicity developed, the daily dose had to be reduced to 500-600 mg/day. At these lower doses, plasma concentrations for a considerable segment of the dosing interval are often below the assay sensitivity for the high-perf
Prevalence of hepatitis G virus RNA in French blood donors and recipients [see comments]: Transfusion. 1997 Jun;37(6):645-50. Unique Identifier : AIDSLINE MED/97335161; Loiseau P; Mariotti M; Corbi C; Ravera N; Girot R; Thauvin M; Portelette E; Mariette X; Roudot-Thoraval F; Benbunan M; Lefrere JJ; Etablissement de Transfusion Sanguine de l'Assistance; Publique-Hopitaux de Paris (AP-HP), Site Saint-Louis, France.; BACKGROUND: Recently, cases of chronic hepatitis were linked to the presence of genomic sequences of a newly described RNA virus termed hepatitis G virus (HGV) and belonging to the Flaviviridae family. STUDY DESIGN AND METHODS: The presence of HGV RNA was searched for by polymerase chain reaction in a population of bl
Interpretation of false-positive human immunodeficiency virus type 1 western blot assays in blood donors [letter]: Transfusion. 1997 Jun;37(6):670. Unique Identifier : AIDSLINE MED/97335166; Cable RG; Badon SJ; Trouem-Trend JJ; Popovsky MA
Database of HIV proteinase structures.: Trends Biochem Sci. 1997 May;22(5):183. Unique Identifier : AIDSLINE MED/97318602; Vondrasek J; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and; Development Center, Frederick, MD 21702, USA.
Evaluation of a new HTLV-I/II polymerase chain reaction.: Vox Sang. 1997;72(3):144-7. Unique Identifier : AIDSLINE MED/97290845; Vrielink H; Zaaijer HL; Cuypers HT; van der Poel CL; Woerdeman M; Lelie PN; Winkel C; Reesink HW; Red Cross Blood Bank Amsterdam, The Netherlands.; AIM: Evaluation of a qualitative HTLV-I/II DNA polymerase chain reaction (PCR) test for the detection of HTLV-I/II DNA (Roche Diagnostic Systems, Branchburg, N.J., USA) in various panels. METHODS: The panels consisted of fresh EDTA blood samples from blood donors who were anti-HTLV-I/II ELISA repeatably reactive: 53 w
[Cytotoxic T-lymphocytes and the recognition of tumor antigens--an approach to "preventive tumor vaccination?"]: Zentralbl Chir. 1997;122(3):141-8. Unique Identifier : AIDSLINE MED/97274958; Peiper M; Goedegebuure PS; Eberlein TJ; Zornig C; Biological Cancer Therapy Laboratory, Department of Surgery, Brigham &; Women's Hospital, Harvard Medical School, USA.; In spite of modifications of the intra- and postoperative therapeutic strategy as well as new adjuvant protocols, most malignant diseases have a poor prognosis. This demonstrates the need for new approaches in tumor therapy. One alternative is adoptive immunotherapy (AIT). AIT is based on the observation that cytotoxi
[Acute and chronic diarrhea in AIDS: study of 435 (HIV+) patients, in Buenos Aires]: Acta Gastroenterol Latinoam. 1996;26(1):15-22. Unique Identifier : AIDSLINE MED/97283547; Merlin M; Gandara S; Iannicillo H; Dutack A; Raffo L; Di Bartolomeo S; Di Bella A; Pelluffo G; Varsky C; Hospital Nacional Prof. A. Posadas Prov. Buenos Aires, Argentina.; OBJECTIVE: Assessment of the rate of Diarrhoea in an infected HIV population of our medium. Assessment of its etiology, risk factors and response to treatment in both presentation of disease Acute and chronic). DESIGN: This is a retrospective analysis of HIV and/or AIDS patients and diarrhea. The analytic points were:
[Diarrhea and AIDS: more complex diagnostic techniques; better therapeutic results]: Acta Gastroenterol Latinoam. 1996;26(2):91-100. Unique Identifier : AIDSLINE MED/97283558; Olmos M; Molina C; Piskorz E; Tawil J; Magnanini F; Casiro A; Cahn P; Concetti H; Janeiro M; Guelfand L; Kaufman S; Division de Gastroenterologia, Hospital Municipal J. A. Fernandez,; Buenos Aires, Argentina.; During 17 months, 73 HIV-positive patients with diarrhea lasting at least for 14 days, were studied prospectively. The patients had stool specimen examinations negative for enteric pathogens, or positive for one of them, but with no response to specific treatment. All patients were subcomitted to digestive endoscopy a
Treatment of AIDS and HIV-related conditions--1997.: J Am Board Fam Pract. 1997 Mar-Apr;10(2):144-67. Unique Identifier : AIDSLINE MED/97225324; Goldschmidt RH; Dong BJ; Family Practice Residency Program, San Francisco General Hospital, CA; 94110, USA.
Seroprevalence and coprevalence of HIV and HBsAg in Nigerian children with/without protein energy malnutrition.: Acta Trop. 1997 Apr 15;64(3-4):167-74. Unique Identifier : AIDSLINE MED/97261410; Akenami FO; Koskiniemi M; Ekanem EE; Bolarin DM; Vaheri A; Haartman Institute, Department of Virology, University of Helsinki,; Finland. Francis.Akenami@Helsinki.FI; In order to assess the seroprevalence and coprevalence of hepatitis-B surface antigen (HBsAg), human immunodeficiency virus-1 and -2 (HIV-1 and -2) antibodies in Nigerian children with/without protein energy malnutrition (PEM), we studied plasma specimens of 206 children with PEM and 200 apparently healthy reference c
[Molecular biology at the service of the daily medical virology. 2. Applications to virological diagnosis]: Ann Biol Clin (Paris). 1997 Mar-Apr;55(2):81-91. Unique Identifier : AIDSLINE MED/97324890; Wattre P; Service de virologie, CHRU, Institut Gernez-Rieux, Lille.; Molecular biology techniques are applied for the diagnosis of meningoencephalitis due to herpesviruses, enteroviruses or polyomaviruses, for the diagnosis of human cytomegalovirus , human parvovirus B19, varicella-zoster virus and rubella virus infections occurring during pregnancy,
[Pulmonary tuberculosis in 1996. Recent data and practical consequences for the anesthesiologist]: Ann Fr Anesth Reanim. 1996;15(7):1080-7. Unique Identifier : AIDSLINE MED/97324913; Veber B; Service de reanimation chirurgicale, hopital Charles-Nicolle, Rouen,; France.; Tuberculosis is one of the most widespread diseases, occurring in more than eight million persons, and about three million die annually of tuberculosis. In industrialized countries, the incidence has increased significantly over the last 10 years. HIV infection is a main factor leading to this increase. Outbreaks of n
Structure-based drug design: computational advances.: Annu Rev Pharmacol Toxicol. 1997;37:71-90. Unique Identifier : AIDSLINE MED/97277871; Marrone TJ; Briggs JM; McCammon JA; Department of Chemistry and Biochemistry, University of California San; Diego, La Jolla 92093-0365, USA.; Structure-based computational methods continue to enhance progress in the discovery and refinement of therapeutic agents. Several such methods and their applications are described. These include molecular visualization and molecular modeling, docking, fragment methods, 3-D database techniques, and free-energy perturba
Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract.: Biochem Biophys Res Commun. 1997 Apr 28;233(3):742-7. Unique Identifier : AIDSLINE MED/97312484; Tsukahara S; Suzuki J; Hiratou T; Takai K; Koyanagi Y; Yamamoto N; Takaku H; Department of Industrial Chemistry, Chiba Institute of Technology,; Japan.; We show the effects of triple-helix formation by assays of primer extension inhibition in vitro using two systems two-strand-system (FTFOs) or three-strand-system (TFOs) targeted to the polypurine tract (PPT) of HIV-1. The FTFOs were more effective than the TFOs. We found that the FTFOs containing phosphorothioate gro
Integration of HTLV-1 provirus into mouse transforming growth factor-alpha gene.: Biochem Biophys Res Commun. 1997 Apr 28;233(3):792-5. Unique Identifier : AIDSLINE MED/97312494; Fang J; Kushida S; Feng R; Tanaka M; Kikukawa H; Kawamura T; Uchida K; Miwa M; Department of Biochemistry and Molecular Oncology, University of; Tsukuba, Ibaraki, Japan.; Human T cell leukemia virus type 1 (HTLV-1) provirus integration was investigated in mice inoculated with MT-2 cells, a HTLV-1 producing human T-cell line. From spleen DNA derived from a MT-2 cell-injected mouse, we cloned a HTLV-1 integration site by ligation-mediated PCR. The nucleotide sequence showed that HTLV-1 p
[Progressive hearing loss in children with hearing aids]: Laryngorhinootologie. 1997 Mar;76(3):123-6. Unique Identifier : AIDSLINE MED/97280154; Streppel M; Betten T; von Wedel H; Eckel HE; Damm M; Klinik und Poliklinik fur Hals-Nasen-Ohrenheilkunde,; Kopf-Halschirurgie, Universitat Koln.; BACKGROUND: The possibility of hearing aid induced deterioration was first described in 1939 (Berry 1939, Holmgren 1939). Since then numerous studies discussed this problem controversely. However, it is undisputed that in cases of profound sensorineural hearing loss in childhood powerful hearing aids are necessary for
The Th1/Th2 paradigm.: Immunol Today. 1997 Jun;18(6):263-6. Unique Identifier : AIDSLINE MED/97334004; Romagnani S; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy. s.romagnani@mednuc2
Minimising the dosage-limiting toxicities of foscarnet induction therapy.: Drug Saf. 1997 Apr;16(4):258-66. Unique Identifier : AIDSLINE MED/97268230; Jayaweera DT; University of Miami School of Medicine, Florida, USA.; This article suggests ways to manage the dose-limiting adverse reactions caused by foscarnet so that this agent may be used with confidence as first-line therapy in patients with cytomegalovirus CMV ) disease. Foscarnet (triso
Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients.: AIDS. 1997 Mar 15;11(4):F29-33. Unique Identifier : AIDSLINE MED/97239094; Merry C; Barry MG; Mulcahy F; Ryan M; Heavey J; Tjia JF; Gibbons SE; Breckenridge AM; Back DJ; Department of Pharmacology and Therapeutics, University of Liverpool,; UK.; OBJECTIVE: The most important hepatic enzyme involved in the metabolism of protease inhibitors is cytochrome P450 3A4 CYP3A4). Ritonavir (RIT) is a potent inhibitor of CYP3A4 and inhibits saquinavir
Implications of HIV variability for transmission: scientific and policy issues. Expert Group of the Joint United Nations Programme on HIV/AIDS.: AIDS. 1997 Mar 15;11(4):UNAIDS1-15. Unique Identifier : AIDSLINE MED/97239127
HIV-1 and the thymus [editorial]: AIDS. 1997 Mar 15;11(4):403-14. Unique Identifier : AIDSLINE MED/97239095; Gaulton GN; Scobie JV; Rosenzweig M
Divergence of HIV-1 quasispecies in an epidemiologic cluster.: AIDS. 1997 Mar 15;11(4):415-22. Unique Identifier : AIDSLINE MED/97239096; Diaz RS; Zhang L; Busch MP; Mosley JW; Mayer A; Irwin Memorial Blood Centers, San Francisco, CA 94118, USA.; BACKGROUND: During treatment with blood components prepared from an HIV-infected donation, two recipients became infected in 1985. One recipient infected her sexual partner. OBJECTIVE: To evaluate the evolution of the originally-shared HIV-1 quasispecies in different human hosts over time, sequence data were obtained
Tumour necrosis factor c2 microsatellite allele is associated with the rate of HIV disease progression.: AIDS. 1997 Mar 15;11(4):423-8. Unique Identifier : AIDSLINE MED/97239097; Khoo SH; Pepper L; Snowden N; Hajeer AH; Vallely P; Wilkins EG; Mandal BK; Ollier WE; Department of Infectious Diseases, Monsall Unit, North Manchester; General Hospital, UK.; BACKGROUND: The rate of immunological deterioration and progression to AIDS differs markedly between HIV-positive individuals, and may be influenced by cofactors, HIV phenotype and host T-cell response. Tumour necrosis factor (TNF)-alpha and lymphotoxin stimulate HIV replication and may induce apoptosis of HIV-infecte
Timing of maternal-infant HIV transmission: associations between intrapartum factors and early polymerase chain reaction results. New York City Perinatal HIV Transmission Collaborative Study Group.: AIDS. 1997 Mar 15;11(4):429-35. Unique Identifier : AIDSLINE MED/97239098; Kuhn L; Abrams EJ; Matheson PB; Thomas PA; Lambert G; Bamji M; Greenberg B; Steketee RW; Thea DM; Sergievsky Center, Columbia University, New York, NY 10032, USA.; OBJECTIVE: To investigate the hypothesis that labour and delivery events, perinatal characteristics, and maternal factors are only associated with intrapartum HIV transmission, and not with intrauterine HIV transmission. METHODS: In the New York City Perinatal HIV Transmission Collaborative Study 276 infants of HIV-in
The effect of maternal viral load on the risk of perinatal transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group.: AIDS. 1997 Mar 15;11(4):437-44. Unique Identifier : AIDSLINE MED/97239099; Thea DM; Steketee RW; Pliner V; Bornschlegel K; Brown T; Orloff S; Matheson PB; Abrams EJ; Bamji M; Lambert G; Schoenbaum EA; Thomas PA; Heagarty M; Kalish ML; Medical and Health Research Association, New York, New York, USA.; OBJECTIVE: To determine the effect of maternal viral load at delivery on the risk of perinatal transmission of HIV-1. DESIGN: A nested case-control study within a prospectively followed cohort of HIV-1-infected pregnant women and their infants. SETTING: The multicenter New York City Perinatal HIV Transmission Collabor
Serological and virological characterization of HIV-1 group O infection in Cameroon.: AIDS. 1997 Mar 15;11(4):445-53. Unique Identifier : AIDSLINE MED/97239100; Mauclere P; Loussert-Ajaka I; Damond F; Fagot P; Souquieres S; Monny Lobe M; Mbopi Keou FX; Barre-Sinoussi F; Saragosti S; Brun-Vezinet F; Simon F; Centre Pasteur du Cameroun, National Public Health and Reference; Laboratory Yaounde, Cameroun.; OBJECTIVES: To study the presence of HIV-1 group O infection among HIV-infected people in Cameroon and to further characterize the HIV-1 group O infections. DESIGN AND METHODS: During a 2-year survey (1994-1995), all samples tested positive in screening methods in the National Re
Site of disease and opportunistic infection predict survival in HIV-associated tuberculosis.: AIDS. 1997 Mar 15;11(4):455-60. Unique Identifier : AIDSLINE MED/97239101; Whalen C; Horsburgh CR Jr; Hom D; Lahart C; Simberkoff M; Ellner J; Department of Epidemiology and Biostatistics, University Hospitals of; Cleveland, USA.; OBJECTIVE: Infection with HIV adversely affects survival in patients with tuberculosis (TB), even when TB is effectively treated. The aim of this study was to identify the determinants of survival in HIV-associated TB. DESIGN: Retrospective cohort study. SETTING: Four US academic medical centers. PATIENTS: An inceptio
Antiretroviral treatment and progression to AIDS in HIV seroconverters from different risk groups. HIV Italian Seroconversion Study.: AIDS. 1997 Mar 15;11(4):461-7. Unique Identifier : AIDSLINE MED/97239102; Dorrucci M; Pezzotti P; Phillips AN; Alliegro MB; Rezza G; Centro Operativo AIDS, Laboratory of Epidemiology and Biostatistics,; Istituto superiore di Sanita, Rome, Italy.; OBJECTIVES: To evaluate the association between time since initiation of pre-AIDS antiretroviral therapy [mainly with zidovudine (ZDV)] and AIDS-free survival in a cohort of HIV seroconverters, and to assess possible differences in this association and in the use of antiretroviral therapy by HIV exposure group. DESIGN
Three-drug combination of MKC-442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV-1.: AIDS. 1997 Mar 15;11(4):469-75. Unique Identifier : AIDSLINE MED/97239103; Piras G; Nakade K; Yuasa S; Baba M; Division of Human Retroviruses, Faculty of Medicine, Kagoshima; University, Japan.; OBJECTIVES: MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil), a potent non-nucleoside reverse transcriptase inhibitor, is a promising candidate for the treatment of HIV-1 infection and is now undergoing clinical trials. We studied the in vitro activity of MKC-442 against HIV-1 replication in a three-drug combinatio
Reductions in HIV-1 disease progression for zidovudine/lamivudine relative to control treatments: a meta-analysis of controlled trials.: AIDS. 1997 Mar 15;11(4):477-83. Unique Identifier : AIDSLINE MED/97239104; Staszewski S; Hill AM; Bartlett J; Eron JJ; Katlama C; Johnson J; Sawyer W; McDade H; Goethe-Universitat, Frankfurt, Germany.; OBJECTIVES: Four randomized double-blind trials have demonstrated that zidovudine/lamivudine (ZDV/ 3TC ) reduces HIV RNA and raises CD4 counts relative to control treatments (ZDV or ZDV/zalcitabine
Change in circulating levels of the chemokines macrophage inflammatory proteins 1 alpha and 11 beta, RANTES, monocyte chemotactic protein-1 and interleukin-16 following treatment of severely immunodeficient HIV-infected individuals with indinavir.: AIDS. 1997 Mar 15;11(4):485-91. Unique Identifier : AIDSLINE MED/97239105; Bisset LR; Rothen M; Joller-Jemelka HI; Dubs RW; Grob PJ; Opravil M; Division of Clinical Immunology, University Hospital, Zurich,; Switzerland.; OBJECTIVE: To evaluate the in vivo relationship between HIV replication and circulating levels of the chemokines macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, RANTES (acronym for Regulated upon Activation, Normal T-cell Expressed and presumably Secreted), interleukin (IL)-16 and monocyte chemotactic prote
Geographical distribution of HIV-1 group O viruses in Africa.: AIDS. 1997 Mar 15;11(4):493-8. Unique Identifier : AIDSLINE MED/97239106; Peeters M; Gueye A; Mboup S; Bibollet-Ruche F; Ekaza E; Mulanga C; Ouedrago R; Gandji R; Mpele P; Dibanga G; Koumare B; Saidou M; Esu-Williams E; Lombart JP; Badombena W; Luo N; Vanden Haesevelde M; Delaporte E; Laboratoire Retrovirus, ORSTOM, Montpellier, France.; OBJECTIVE: To determine to what extent HIV-1 group O strains are present in different African countries. MATERIALS AND METHODS: A total of 14,682 samples of sera from a range of patients from 12 different African countries were tested. All the sera were tested with an enzyme-linked immunosorbent assay (ELISA) using a
The spread of AIDS and the re-emergence of tuberculosis in Catalonia, Spain.: AIDS. 1997 Mar 15;11(4):499-505. Unique Identifier : AIDSLINE MED/97239107; Vall Mayans M; Maguire A; Miret M; Alcaide J; Parron I; Casabona J; Department of Health and Social Security, University Hospital Germans; Trias i Pujol, Badalona, Spain.; OBJECTIVE: To assess the impact of HIV/AIDS on the incidence of tuberculosis (TB) and to analyse the determinants of TB presenting as the first indicative disease of AIDS. DESIGN: Analysis of TB and AIDS surveillance data. SETTING: Catalonia, north-east Spain . PATIENTS: Two separate
Psychopathology in male and female HIV-positive and negative injecting drug users: longitudinal course over 3 years.: AIDS. 1997 Mar 15;11(4):507-15. Unique Identifier : AIDSLINE MED/97239108; Rabkin JG; Johnson J; Lin SH; Lipsitz JD; Remien RH; Williams JB; Gorman JM; Department of Psychiatry, College of Physicians and Surgeons, Columbia; University, New York, New York, USA.; OBJECTIVE: To evaluate the impact of HIV illness on psychiatric and psychosocial functioning over 3 years in a sample of male and female HIV-positive injecting drug users (IDU), with a comparison group of HIV-negative male and female IDU. DESIGN: As part of a multidisciplinary study, 121 men (69 HIV-positive, 52 HIV-n
Predictors of cytomegalovirus disease, natural history and autopsy findings in a cohort of patients with AIDS.: AIDS. 1997 Mar 15;11(4):517-24. Unique Identifier : AIDSLINE MED/97239109; d'Arminio Monforte A; Mainini F; Testa L; Vago L; Balotta L; Nebuloni M; Antinori S; Bini T; Moroni M; Clinic of Infectious Diseases, L. Sacco Hospital, University of Milan,; Italy.; OBJECTIVE: To identify the predictors of acquiring cytomegalovirus ( CMV ) disease, and to describe natural history, therapeutic management and autopsy findings in affected patients. DESIGN: Observational study of a consecutive
Survival of European patients with Kaposi's sarcoma as AIDS-defining condition during the first decade of AIDS. AIDS in Europe Study Group.: AIDS. 1997 Mar 15;11(4):525-31. Unique Identifier : AIDSLINE MED/97239110; Hermans P; Lundgren J; Sommereijns B; Katlama C; Chiesi A; Goebel FD; Gonzales-Lahoz J; Proenza R; Barton SE; Pedersen C; Clumeck N; Saint-Pierre University Hospital, Brussels, Belgium.; OBJECTIVES: To determine whether the survival of patients with Kaposi s sarcoma as first manifestation of AIDS has changed between 1979 and 1989; and to define whether prognosis factors could be identified. PATIENTS AND METHODS: This is a multicentric retrospective cohort study from 52 centers in 17 European countries
Increased T-helper-type 2 cytokine production in chronic HIV infection is due to interleukin (IL)-13 rather than IL-4 [letter]: AIDS. 1997 Mar 15;11(4):533-4. Unique Identifier : AIDSLINE MED/97239111; Zou W; Dulioust A; Fior R; Durand-Gasselin I; Boue F; Galanaud P; Emilie D
HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase [letter]: AIDS. 1997 Mar 15;11(4):534-6. Unique Identifier : AIDSLINE MED/97239112; Amacker M; Hottiger M; Mossi R; Hubscher U
Identification of a novel HLA-B*2705-restricted cytotoxic T-lymphocyte epitope within a conserved region of HIV-1 Nef [letter]: AIDS. 1997 Mar 15;11(4):536-8. Unique Identifier : AIDSLINE MED/97239113; Goulder PJ; Edwards A; Phillips RE; McMichael AJ
Interleukin-16 does not suppress HIV-1 replication in naturally infected peripheral blood mononuclear cells [letter]: AIDS. 1997 Mar 15;11(4):538-9. Unique Identifier : AIDSLINE MED/97239114; Gao M; Tsuchie H; Detorio MA; Hossain MM; Owatari S; Zhang J; Taniguchi K; Nishimoto A; Shirono H; Koga J; Takata N; Matsumoto T; Yoshizaki K; Kurimura T
HIV-1 primary infection in two pairs of patients: difference in variants transmitted and clinical follow-up [letter]: AIDS. 1997 Mar 15;11(4):539-42. Unique Identifier : AIDSLINE MED/97239115; Innocenti-Francillard P; Brengel-Pesce K; Morand P; Ounanian-Paraz A; Leclercq P; Gruters R; Seigneurin JM
Threshold of HIV-1 copy numbers for vertical transmission [letter]: AIDS. 1997 Mar 15;11(4):542-3. Unique Identifier : AIDSLINE MED/97239116; Zollner B; Feucht HH; Helling-Giese G; Mattner UM; Schartl W; Polywka S; Laufs R
Shedding of HIV-1 in semen during primary infection [letter]: AIDS. 1997 Mar 15;11(4):543-5. Unique Identifier : AIDSLINE MED/97239117; Dyer JR; Gilliam BL; Eron JJ Jr; Cohen MS; Fiscus SA; Vernazza PL
Increase of HIV seroprevalence among professional prostitutes in Italy [letter]: AIDS. 1997 Mar 15;11(4):545-6. Unique Identifier : AIDSLINE MED/97239118; Spina M; Mancuso S; Sinicco A; Vaccher E; Traina C; Di Fabrizio N; de Lalla F; Tirelli U
Condom use in two rural districts of Lira and Soroti in Uganda [letter]: AIDS. 1997 Mar 15;11(4):546-8. Unique Identifier : AIDSLINE MED/97239119; Opio AA; Asiimwe-Okiror G; Musinguzi J; Kaweesa-Kisitu D; Madraa E; Nsubuga P
Adding saquinavir to stavudine in patients with advanced HIV-1 infection [letter]: AIDS. 1997 Mar 15;11(4):548. Unique Identifier : AIDSLINE MED/97239120; Rutschmann OT; Kaiser L; Perrin L; Fathi M; Hirschel BJ
Pneumocystis carinii hominis sequencing to study hypothetical person-to-person transmission [letter]: AIDS. 1997 Mar 15;11(4):549. Unique Identifier : AIDSLINE MED/97239121; Latouche S; Poirot JL; Maury E; Bertrand V; Roux P
Rising incidence of human T-cell leukaemia/lymphoma virus type II in Spanish drug users [letter]: AIDS. 1997 Mar 15;11(4):549-50. Unique Identifier : AIDSLINE MED/97239122; Soriano V; Martinez-Zapico R; Gutierrez M; Guerra A; Dronda F
Miller Fisher syndrome in a patient with HIV infection [letter]: AIDS. 1997 Mar 15;11(4):550-1. Unique Identifier : AIDSLINE MED/97239123; Arranz Caso JA; Martinez R; Cabrera F; Tejeiro J
Early foscarnet failure in herpes simplex virus infection in a patient with AIDS [letter]: AIDS. 1997 Mar 15;11(4):552-3. Unique Identifier : AIDSLINE MED/97239124; Segal BH; Engler HD; Little R; Wilson WH; Freifeld AG; Chanock SJ
Fulminant hepatic failure caused by microsporidial infection in a patient with AIDS [letter]: AIDS. 1997 Mar 15;11(4):553-4. Unique Identifier : AIDSLINE MED/97239125; Sheth SG; Bates C; Federman M; Chopra S
AIDS education programme in Colombian medical schools: training the teachers [letter]: AIDS. 1997 Mar 15;11(4):554-5. Unique Identifier : AIDSLINE MED/97239126; Garcia-Bernard R; Shor-Posner G; Klaskala W; Castro J; Baum M
Expression of foreign proteins on the surface of Autographa californica nuclear polyhedrosis virus.: Biotechniques. 1997 Apr;22(4):730-5. Unique Identifier : AIDSLINE MED/97259524; Grabherr R; Ernst W; Doblhoff-Dier O; Sara M; Katinger H; University of Agriculture, Food Science and Forestry, Vienna, Austria.; Based on the method of direct cloning into the baculovirus genome by linearizing and re-ligation in presence of the target insert, we designed viral constructs that express foreign genes on the surface of baculovirus particles. We chose the glycosylated envelope protein gp41 of human immunodeficiency virus type 1 HIV-
Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness.: Am J Respir Cell Mol Biol. 1997 Jun;16(6):674-82. Unique Identifier : AIDSLINE MED/97334803; Hamelmann E; Oshiba A; Schwarze J; Bradley K; Loader J; Larsen GL; Gelfand EW; Department of Pediatrics, National Jewish Medical and Research Center,; Denver, Colorado 80206, USA.; The mechanisms underlying the development of airway hyperresponsiveness are not fully delineated. We addressed this question by studying the effects of passive sensitization with anti-OVA IgE on the development of altered airway responsiveness AR) following local challenge with OVA in normal and athymic mice. Both nor
An interactive Web site providing major histocompatibility ligand predictions: application to HIV research.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):529-31. Unique Identifier : AIDSLINE MED/97281562; De Groot AS; Jesdale BM; Szu E; Schafer JR; Chicz RM; Deocampo G; TB/HIV Research Laboratory, Brown University School of Medicine,; Providence, Rhode Island 02912, USA.; EpiMatrix/HIV, a tool that is currently available on the World Wide Web, enables researchers to screen HIV proteins for potential MHC ligands. We have performed a comparison of EpiMatrix predictions to 158 published allotype-specific HLA-associated peptides (MHC ligands) derived from 133 proteins. The top 10 ranked Ep
Wild-type and mutant HIV type 1 nucleocapsid proteins increase the proportion of long cDNA transcripts by viral reverse transcriptase.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):533-43. Unique Identifier : AIDSLINE MED/97281563; Drummond JE; Mounts P; Gorelick RJ; Casas-Finet JR; Bosche WJ; Henderson LE; Waters DJ; Arthur LO; NCI-Frederick Cancer Research and Development Center, SAIC Frederick,; Maryland 21702, USA.; HIV-1 nucleocapsid, p7, contains two retroviral zinc fingers, which are both necessary for efficient packaging of genomic RNA and infectivity. The nucleocapsid protein is bound tightly to genomic RNA in the mature virion. In this study, the effect of p7 on polymerization of nascent cDNA by viral reverse transcriptase
The multiple inhibitory mechanisms of GEM 91, a gag antisense phosphorothioate oligonucleotide, for human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):545-54. Unique Identifier : AIDSLINE MED/97281564; Yamaguchi K; Papp B; Zhang D; Ali AN; Agrawal S; Byrn RA; Division of Hematology/Oncology, Beth Israel Deaconess Medical Center,; Harvard Medical School, Boston, Massachusetts 02215, USA.; GEM 91 (gene expression modulator) is a 25-mer oligonucleotide phosphorothioate complementary to the gag initiation site of HIV-1. GEM 91 has been studied in various in vitro cell culture models to examine inhibitory effects on different stages of HIV-1 replication. Experiments were focused on the binding of virions t
Correlation between changes in plasma HIV RNA levels and in plasma infectivity in response to antiretroviral therapy.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):555-61. Unique Identifier : AIDSLINE MED/97281565; Andreoni M; Sarmati L; Ercoli L; Nicastri E; Giannini G; Galluzzo C; Pirillo MF; Vella S; Department of Public Health and Cellular Biology, University of Tor; Vergata, Rome, Italy.; We evaluated the degree of correlation between the variation of different HIV-1 viral load measures in response to antiretroviral therapy. A quantitative reverse transcriptase polymerase chain reaction (RT-PCR) for plasma HIV-RNA, and HIV plasma infectivity titration, were performed on prospective samples obtained fro
Clonal selection of HIV type 1 variants associated with resistance to foscarnet in vitro: confirmation by molecular evolutionary analysis.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):563-73. Unique Identifier : AIDSLINE MED/97281566; Nakano T; Morozumi H; Inuzuka S; Nagata M; Taguchi Y; Mizokami M; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, Japan.; Foscarnet (trisodium phosphonoformate, PFA) is an effective inhibitor of retroviral reverse transcriptase (RT) and is known to block the replication of human immunodeficiency virus type 1 HIV-1). In this article we analyzed the evolutionary process in generating HIV-1 strains related to drug resistance, using PFA as a
Recombinant human monoclonal antibody IgG1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):575-82. Unique Identifier : AIDSLINE MED/97281567; Kessler JA 2nd; McKenna PM; Emini EA; Chan CP; Patel MD; Gupta SK; Mark GE 3rd; Barbas CF 3rd; Burton DR; Conley AJ; Department of Antiviral Research, Merck Research Laboratories, West; Point, Pennsylvania 19486, USA.; The CD4-binding domain of human immunodeficiency virus type 1 HIV-1) gp120 elicits antibodies that are present in infected human sera. Monoclonal antibodies that recognize the HIV-1 gp120 CD4-binding domain have been isolated. Some of these antibodies can neutralize laboratory-adapted strains of HIV-1 and probably med
Characterization and titration of an HIV type 1 subtype E chimpanzee challenge stock.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):583-91. Unique Identifier : AIDSLINE MED/97281568; Barre-Sinoussi F; Georges-Courbot MC; Fultz PN; Nguyen Thi Tuyet H; Muchmore E; Saragosti S; Dubreuil G; Georges A; van der Ryst E; Girard M; Institut Pasteur, Paris, France.; A subtype E human immunodeficiency virus type 1 (HIV-1) isolate from the Central African Republic (E/90CR402) was adapted to growth on chimpanzee peripheral blood mononuclear cells (PBMCs) by cocultivation of irradiated, infected human PBMCs with chimpanzee PBMCs. T
Live attenuated SIV vaccines are not effective in a postexposure vaccination model.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):593-9. Unique Identifier : AIDSLINE MED/97281569; Linhart H; Gundlach BR; Sopper S; Dittmer U; Matz-Rensing K; Kuhn EM; Muller J; Hunsmann G; Stahl-Hennig C; Uberla K; Institute of Clinical and Molecular Virology, University of; Erlangen-Nurnberg, Germany.; Live attenuated simian immunodeficiency virus (SIV) vaccines, like nef deletion mutants, have been the most effective vaccines tested in the SIV/macaque model so far. The efficacy of live attenuated SIV vaccines in therapeutic vaccination and postexposure prophylaxis has not been determined. Inoculation of macaques wi
Reverse transcriptase and corresponding activity-blocking antibody for monitoring SIVsm infection in macaques.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):601-10. Unique Identifier : AIDSLINE MED/97281570; Ekstrand DH; Bottiger D; Andersson H; Gronowitz JS; Clas FR; Department of Medical Genetics, Uppsala University, BMC, Sweden.; A nonradioactive reverse transcriptase (RT) assay was used to measure RT activity in serum during the viremia peak associated with primary infection and for measuring the generation and maintenance of RT activity-blocking antibody (RTb-ab) titers during and after seroconversion in SIV-infected macaques. The RT assay w
Selective thymocyte depletion and immunoglobulin coating in the thymus of cats infected with feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):611-20. Unique Identifier : AIDSLINE MED/97281571; Orandle MS; Papadi GP; Bubenik LJ; Dailey CI; Johnson CM; Department of Pathobiology, University of Florida, Gainesville 32610,; USA.; Thymus alterations associated with feline immunodeficiency virus FIV), an AIDS animal model, were investigated by measuring phenotypic composition of thymocytes, structure of thymic epithelial cells, and transcription of viral RNA in the thymus of FIV-infected juvenile kittens. These kittens either acquired infection
Phylogenetic analysis of HIV type 2 in Ghana and intrasubtype recombination in HIV type 2.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):621-3. Unique Identifier : AIDSLINE MED/97281572; Takehisa J; Osei-Kwasi M; Ayisi NK; Hishida O; Miura T; Igarashi T; Brandful J; Ampofo W; Netty VB; Mensah M; Yamashita M; Ido E; Hayami M; Laboratory of Pathogenic Virus, Kyoto University, Japan.
First human immunodeficiency virus type 1 sequences in the V3 region, nef and vpr genes from Papua New Guinea.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):625-7. Unique Identifier : AIDSLINE MED/97281573; Dwyer DE; Ge YC; Wang B; Bolton WV; McCormack JG; Cunningham AL; Saksena NK; Retroviral Genetics Laboratory, Westmead Institutes of Health; Research, CIDM, Westmead Hospital, Australia.
Selected nucleotide sequence of the pol gene of the monocytotropic strain HIV type 1 BaL.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):629-32. Unique Identifier : AIDSLINE MED/97281574; Cenci A; Perno CF; Menzo S; Clementi M; Erba F; Tavazzi B; Di Pierro D; Aquaro S; Calio R; Dipartimento di Medicina Sperimentale e Scienze Biochimiche,; Universita di Roma Tor Vergata, Italy.
Substituent effects on the enantioselective retention of anti-HIV 5-aryl-delta 2-1,2,4-oxadiazolines on R,R-DACH-DNB chiral stationary phase.: Chirality. 1996;8(8):556-66. Unique Identifier : AIDSLINE MED/97177749; Altomare C; Cellamare S; Carotti A; Barreca ML; Chimirri A; Monforte AM; Gasparrini F; Villani C; Cirilli M; Mazza F; Dipartimento Farmaco-Chimico, Universita di Bari, Italy.; A series of racemic 3-phenyl-4-(1-adamantyl)-5-X-phenyl- delta 2-1,2,4-oxadiazo lines (PAdOx) were directly resolved by HPLC using a Pirkle-type stationary phase containing N,N -(3,5-dinitrobenzoyl)-1(R),2(R)-diaminocyclohexane as chiral selector. The more retained enantiomers have S configuration, as demonstrated by
Differential expression of nucleoskeleton- and cytoskeleton-associated proteins in Burkitt lymphoma-derived and Epstein-Barr virus-immortalized lymphoblastoid cell lines.: Cell Growth Differ. 1997 May;8(5):599-609. Unique Identifier : AIDSLINE MED/97294027; Szekely L; Pokrovskaja K; Klein G; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Mouse monoclonal antibodies raised against nuclear bodies isolated from an EBV-immortalized lymphoblastoid cell line (LCL) known to contain several viral and cellular proteins (Jiang et al., Exp. Cell Res., 197: 314-318, 1991; Szekely et al., J. Gen. Virol., 76: 2423-2432, 1995; Szekely et al., J. Virol., 70: 2562-256
Antenatal testing for HIV: to opt in or opt out, that is the question [letter; comment]: Br J Obstet Gynaecol. 1997 Jun;104(6):758. Unique Identifier : AIDSLINE MED/97341566; MacDonagh SE; Mercey D; Kennedy J; Blott M
Structure-based thermodynamic analysis of HIV-1 protease inhibitors.: Biochemistry. 1997 Jun 3;36(22):6588-96. Unique Identifier : AIDSLINE MED/97327471; Bardi JS; Luque I; Freire E; Department of Biology and Biocalorimetry Center, The Johns Hopkins; University, Baltimore, Maryland 21218, USA.; A structural parametrization of the binding and folding energetics previously developed in this laboratory accounts quantitatively for the binding of 13 HIV-1 protease inhibitors for which high-resolution structures are available (A77003, A78791, A76928, A74704, A76
Psychosocial characteristics of HIV-infected adolescents in New Orleans [letter]: J Adolesc Health. 1997 Apr;20(4):258. Unique Identifier : AIDSLINE MED/97253284; Kissinger P; Fuller C; Clark RA; Abdalian SE
Interferon-gamma expression in macaque lymph nodes during primary infection with simian immunodeficiency virus.: Cytokine. 1996 Nov;8(11):844-52. Unique Identifier : AIDSLINE MED/97199106; Khatissian E; Monceaux V; Cumont MC; Montagnier L; Hurtrel B; Chakrabarti L; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; Simian immunodeficiency virus (SIV) replication is rapidly downregulated in the lymph nodes (LN) of rhesus macaques after the acute stage of primary infection. The aim of this study was to evaluate a possible role of interferon-gamma (IFN-gamma) in the control of SIV replication. IFN-gamma expression was analysed by i
[Effect of L-lysine-alpha-oxidase on the synthesis of cell proteins, targets of autoimmune pathology in HIV infection]: Biull Eksp Biol Med. 1997 Jan;123(1):36-8. Unique Identifier : AIDSLINE MED/97210977; Berezov TT; Zverev VV; Zaitsev IZ; Alekseev SB
Hematopoietic potential and retroviral transduction of CD34+ Thy-1+ peripheral blood stem cells from asymptomatic human immunodeficiency virus type-1-infected individuals mobilized with granulocyte colony-stimulating factor.: Blood. 1997 Jun 15;89(12):4299-306. Unique Identifier : AIDSLINE MED/97335957; Junker U; Moon JJ; Kalfoglou CS; Sniecinski I; Forman SJ; Zaia JA; Kaneshima H; Bohnlein E; Progenesys Program, Systemix Inc, Palo Alto, CA 94304, USA.; The potential of hematopoietic stem cells (HSCs) from human immunodeficiency virus type-1 (HIV-1)-infected individuals, eg, self-renewal and multilineage differentiative capacity, might be perturbed due to the underlying disease. In this study, we assessed the HSC activity in the CD34+ Thy-1+ cell population of periph
Pathological and epidemiological aspects of skin lesions in histoplasmosis. Observations in an AIDS patient and badgers outside endemic areas of histoplasmosis.: Zentralbl Bakteriol. 1997 Apr;285(4):531-9. Unique Identifier : AIDSLINE MED/97290159; Grosse G; Staib F; Rapp J; Rang H; Heise W; Kaufman L; Institut fur Pathologie, Auguste-Viktoria-Krankenhaus, Berlin,; Germany.; As a consequence of HIV infection, histoplasmosis is increasingly occurring as an opportunistic infection with a systemic course outside histoplasmosis-endemic areas, e.g. in Europe. Accordingly, questions concerning the epidemiology of this mycosis arise. Two incidents involving histoplasmosis in man and badgers with
I.v. access options for AIDS patients with cytomegalovirus disease.: Br J Nurs. 1997 May 22-Jun 11;6(10):543-6, 548, 550-3. Unique Identifier : AIDSLINE MED/97341261; Sargent J; Nixon E; Community Liaison Team, St. Mary's Paddington.; In view of changes over the past 2 years in the intravenous i.v.) management of patients with AIDS and cytomegalovirus ( CMV ) disease, a small study was carried out at the Kobler Clinic, an HIV treatment centre in London, to e
AIDS mania.: J Neuropsychiatry Clin Neurosci. 1997 Spring;9(2):277-9. Unique Identifier : AIDSLINE MED/97289186; Lyketsos CG; Schwartz J; Fishman M; Treisman G; AIDS Psychiatry Service and Neuropsychiatry and Memory Group, Johns; Hopkins University, Baltimore, Maryland 21287, USA.; Twenty patients with HIV infection and mania were grouped according to whether their first manic episode occurred when CD4 count was or = 200 (early onset). The late-onset patients were less likely to have personal or family histories of mood disorder and more likely to have
A SHOT in the arm for safer blood transfusion [editorial]: BMJ. 1996 Nov 16;313(7067):1221-2. Unique Identifier : AIDSLINE MED/97093560; Williamson LM; Heptonstall J; Soldan K
Healthy sexual lifestyle should be emphasised when negative results of HIV tests are given [letter; comment]: BMJ. 1996 Nov 16;313(7067):1259. Unique Identifier : AIDSLINE MED/97093591; Curless E
In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid.: Biol Pharm Bull. 1997 Feb;20(2):175-80. Unique Identifier : AIDSLINE MED/97210953; Komai T; Yagi R; Suzuki-Sunagawa H; Sakurai M; Higashida S; Sugano M; Handa H; Mohri H; Yasuoka A; Oka S; Yabe Y; Nishigaki T; Kimura S; Shimada K; Biological Research, Laboratory, Sankyo Co., Ltd., Tokyo, Japan.; In a series of compounds containing 2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), a transitionstate mimetic, R-87366:(2S,3S)-3-[N-(quinoxaline-2-carbonyl)-L-asparaginyl]amino- 2-hydroxy-4-phenylbutanoyl-L-proline tert-butylamide, was found to be a potent human immunodeficiency virus protease inhibitor Ki val
Isolation of type 1 and type 2 cloned mite allergen-specific T cells from an asthmatic child.: Pediatr Allergy Immunol. 1996 Nov;7(4):193-8. Unique Identifier : AIDSLINE MED/97295751; Chiang BL; Ding HJ; Chou CC; Hsieh KH; Department of Pediatrics, National Taiwan University College of; Medicine, Taipei, R.O.C.; Allergen-specific T cells have been thought to play a central role in the pathogenesis of asthma. It has been well documented that allergen-specific T cells derived from atopic patients are predominantly of type 2 T helper cell pattern. However, allergen-specific T cells derived in nonatopic normals are of type 1 in c
Parent and adolescent perceived need for parental consent involving research with minors.: Arch Pediatr Adolesc Med. 1997 Jun;151(6):603-7. Unique Identifier : AIDSLINE MED/97336496; Sikand A; Schubiner H; Simpson PM; Division of Adolescent Medicine, Children's Hospital of Michigan,; Wayne State University School of Medicine, Detroit, USA.; OBJECTIVE: To assess parents and adolescents perceived need for parental consent for minor adolescents to participate in minimal risk research studies based on procedural invasiveness (anonymous surveys, interviews, and blood or urine testing) and sensitivity of the topics (sexuality, drug and alcohol use, and sexua
Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when.: J Chromatogr B Biomed Appl. 1997 Feb 7;689(1):91-104. Unique Identifier : AIDSLINE MED/97215120; Fried K; Wainer IW; Department of Oncology, McGill University, Montreal General Hospital,; Que, Canada.; The application of stereoselective chromatographic techniques to bioanalytical problems has become a routine procedure. However, this approach is not always straightforward; particularly when the separation involves chromatographic chiral stationary phases. Matrix interferences and more importantly, overlapping metabo
Neuroimaging of AIDS. I. Central nervous system toxoplasmosis.: Neuroimaging Clin N Am. 1997 May;7(2):171-86. Unique Identifier : AIDSLINE MED/97268960; Ramsey RG; Gean AD; Section of Neuroradiology, Department of Radiology, The University of; Chicago, Priztker School of Medicine, Chicago, Illinois 60637, USA.; Toxoplasmosis is the most common cerebral mass lesion encountered in HIV-positive patients. Previously uncommon, this disease has increased markedly since the AIDS epidemic. There are occasionally unusual appearances of central nervous system toxoplasmosis that make diagnosis by standard imaging techniques difficult o
Neuroimaging of AIDS. I. Fungal infections of the central nervous system.: Neuroimaging Clin N Am. 1997 May;7(2):187-98. Unique Identifier : AIDSLINE MED/97268961; Harris DE; Enterline DS; Department of Radiology, Duke University Medical Center, Durham, North; Carolina 27710, USA.; Fungal infections of the central nervous system are quite uncommon and most frequently occur in immunocompromised patients, such as those with AIDS. This article outlines the most common fungal infections that occur in the central nervous system. Even though fungal infections of the central nervous system, other than
Neuroimaging of central nervous system tuberculosis in HIV-infected patients.: Neuroimaging Clin N Am. 1997 May;7(2):199-214. Unique Identifier : AIDSLINE MED/97268962; Whiteman ML; Department of Radiology, University of Miami School of Medicine,; Miami, Florida 33136, USA.; The recent resurgence of tuberculosis in the United States is in part attributable to the AIDS epidemic. Central nervous system tuberculosis has fairly specific radiographic features, and thus the alert radiologist may be the first to suggest this diagnosis. This article reviews the ne
Neurosyphilis in patients with AIDS.: Neuroimaging Clin N Am. 1997 May;7(2):215-21. Unique Identifier : AIDSLINE MED/97268963; Harris DE; Enterline DS; Tien RD; Department of Radiology, Duke University Medical Center, Durham, North; Carolina 27710, USA.; Syphilis has become much more prevalent because of the dramatic increase in immunocompromised patients. The increase in immunocompromised patients is mainly secondary to AIDS. This article is put forth to refamiliarize the reader with syphilis, specifically neurosyphilis. The neurologic symptomatology and neuroimaging
Intracranial bacterial infections in patients with AIDS.: Neuroimaging Clin N Am. 1997 May;7(2):223-9. Unique Identifier : AIDSLINE MED/97355494; Cohen WA; Division of Neuroradiology, Department of Radiology, University of; Washington School of Medicine, Seattle, Washington 98104-2499, USA.; Nontuberculous, nonsyphilitic intracranial bacterial infections in HIV-positive individuals may be nonspecific presentations of unusual organisms, such as R. equi, B. henselae, Nocardia sp. or L. monocytogenes. In addition, more common organisms, such as Staphylococcus, Streptococcus, or Salmonella sp. may cause an un
Mechanisms of HIV infection of the central nervous system and pathogenesis of AIDS-dementia complex.: Neuroimaging Clin N Am. 1997 May;7(2):231-41. Unique Identifier : AIDSLINE MED/97268964; Dal Canto MC; Division of Neuropathology, Department of Pathology, Northwestern; University Medical School, Chicago, Illinois 60611, USA.; In many patients with AIDS, severe neurologic deficits develop that have been designated the cf2HIV-associated cognitive-motor complex. cf1 Pathologically, these symptoms correlate with a low-grade inflammatory condition, referred to as cf2HIV encephalitis,cf1 in which the most characteristic change is the presence of
Diagnostic imaging contribution in the early stages of HIV infection of the brain.: Neuroimaging Clin N Am. 1997 May;7(2):243-60. Unique Identifier : AIDSLINE MED/97268965; Trotot PM; Gray F; Department of Radiology, Institut Pasteur Hospital, Paris, France.; The neuropathology of full-blown, symptomatic AIDS, established in many large autopsy series, has been described in great detail and is now universally accepted. In contrast, the natural history of the changes occurring in the central nervous system during the earlier states of HIV-1 infection remains poorly understoo
Neuroimaging of AIDS. I. Viral infections.: Neuroimaging Clin N Am. 1997 May;7(2):261-80. Unique Identifier : AIDSLINE MED/97268966; Lizerbram EK; Hesselink JR; Division of Magnetic Resonance Imaging, University of California at; San Diego Medical Center, San Diego, California 92103-8756, USA.; Viral infections of the brain and spinal cord cause significant morbidity and mortality in patients afflicted with AIDS. Debate continues over the specific mechanisms and pathways of how HIV-1 manifests itself in the brain and spinal cord. Attempts to predict which seropositive patients develop neurocognitive deficits
Primary central nervous system lymphoma in patients with AIDS.: Neuroimaging Clin N Am. 1997 May;7(2):281-96. Unique Identifier : AIDSLINE MED/97268967; Ruiz A; Post MJ; Bundschu C; Ganz WI; Georgiou M; Department of Radiology, University of Miami School of Medicine,; Miami, Florida 33136, USA.; Primary central nervous system lymphoma (PCNSL), once considered a rare brain neoplasm, has been steadily increasing in incidence mainly due to an enlarging population of immunosuppressed patients. PCNSL has become the second most common brain space occupying lesion in patients with the acquired immunodeficiency syndr
Postmortem MR imaging of the brains of patients with AIDS.: Neuroimaging Clin N Am. 1997 May;7(2):297-320. Unique Identifier : AIDSLINE MED/97268968; Scatliff JH; Kwock L; Chancellor K; Bouldin TW; Kapoor CC; Castillo M; Department of Radiology, University of North Carolina School of; Medicine at Chapel Hill, Chapel Hill, North Carolina 27599-7510, USA.; Forty-two postmortem formalin-fixed brains of known patients with AIDS were examined with T2-weighted MR imaging before brain cutting. The gross and microscopic brain findings were correlated with the T2 signal changes in the postmortem MR imaging. The brains included examples of progressive multifocal leukoencephalop
Imaging of pediatric central nervous system HIV infection.: Neuroimaging Clin N Am. 1997 May;7(2):321-39. Unique Identifier : AIDSLINE MED/97268969; States LJ; Zimmerman RA; Rutstein RM; Division of Pediatric Radiology, Department of Diagnostic Imaging,; Children's Hospital, Yale University School of Medicine, New Haven,; Connecticut, USA.; With the increasing incidence of pediatric HIV infection, distinct patterns of central nervous system involvement, different from those in adults, are being recognized. This article illustrates the spectrum of neuroimaging findings seen in HIV-infected children with central nervous system involvement. Case examples in
Diagnostic imaging of infections and neoplasms affecting the spine in patients with AIDS.: Neuroimaging Clin N Am. 1997 May;7(2):341-57. Unique Identifier : AIDSLINE MED/97268970; Thurnher MM; Jinkins JR; Post MJD; Neuroradiology Section, Department of Radiology, University Hospital; of Vienna, Vienna, Austria.; The central nervous system may be affected by AIDS in the form of infections or neoplasia and by HIV itself. The spine and spinal cord are involved more commonly than documented. MR imaging is the most sensitive imaging technique for the detection of AIDS-related abnormalities in the spine and spinal cord. The early d
Spinal cord lesions in patients with AIDS.: Neuroimaging Clin N Am. 1997 May;7(2):359-73. Unique Identifier : AIDSLINE MED/97268971; Quencer RM; Post MJ; Department of Radiology, University of Miami School of Medicine,; Miami, Florida 33136, USA.; In the past, little attention has been given in the imaging literature to spinal cord findings in the human immunodeficiency syndrome. This article summarizes the major pathologic conditions found in the spinal cord in patients with AIDS and compares them to MR features. The details of toxoplasma myelitis, spinal cord
Imaging of otolaryngologic manifestations of HIV infection.: Neuroimaging Clin N Am. 1997 May;7(2):375-99. Unique Identifier : AIDSLINE MED/97268972; Fischbein NJ; Dillon WP; Division of Neuroradiology, Department of Radiology, University of; California at San Francisco, San Francisco, California 94143-0628,; USA.; Patients infected with HIV have severely depressed immune function and are therefore vulnerable to many infectious and neoplastic processes. Head and neck manifestations initially were reported in approximately 40% of patients with AIDS, but in the course of HIV infection and progression to full-blown AIDS, it is now
Chemokines and HIV: a remarkable synergism.: Trends Microbiol. 1997 Mar;5(3):88-90. Unique Identifier : AIDSLINE MED/97235485; Moser B; Theodor Kocher Institute, University of Bern, Switzerland.; bmoser@tki.unibe.ch
Immune selection and virus evolution: be cautious of paradigms [letter]: Trends Microbiol. 1997 Mar;5(3):92-3. Unique Identifier : AIDSLINE MED/97235487; Daenke S
Characterization of metal-ion-nucleotide based particulate matter in solutions of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).: PDA J Pharm Sci Technol. 1997 Jan-Feb;51(1):30-5. Unique Identifier : AIDSLINE MED/97253680; Yuan LC; Visor GC; Department of Formulation and Process Development, Gilead Sciences,; Incorporated, Foster City, California 94404, USA.; The antiviral drug 9-[2-(phosphonomethoxy)ethyl]adenine, PMEA, was developed as an intravenous product for the treatment of human immunodeficiency virus infection. During the course of stability monitoring, PMEA i.v. injection was found to undergo particulate matter formation under extended storage at ambient temperat
Women find their voices. The success of community outreach and case finding.: N HC Perspect Community. 1997 Mar-Apr;18(2):62-7. Unique Identifier : AIDSLINE MED/97349346; Ireland M; Krauss BJ; Rutgers State University, Newark, NJ, USA.; Families in transition (FIT), a joint program between Beth Israel Medical Center (BIMC) and National Development and Research Institutes, Inc., uses indigenous neighborhood women, Companeras companions), to conduct street outreach in a New York City neighborhood where HIV infection is rampant. The outreach workers inf
Heightened transmigrating activity of CD4-positive T cells through reconstituted basement membrane in patients with human T-lymphotropic virus type I-associated myelopathy.: Proc Assoc Am Physicians. 1997 May;109(3):228-36. Unique Identifier : AIDSLINE MED/97299237; Furuya T; Nakamura T; Shirabe S; Nishiura Y; Tsujino A; Goto H; Nakane S; Eguchi K; Nakamura H; Nagataki S; First Department of Internal Medicine, Nagasaki University School of; Medicine, Japan.; We investigated the transmigrating activity of peripheral blood T cells of patients with human T-lymphotropic virus type I-associated myelopathy (HAM) through reconstituted basement membrane. The transmigrating activity of CD4+ T cells of HAM patients was increased significantly in comparison to that of anti-HTLV-I-se
Importance of anti-HIV-1 antibodies [letter; comment]: Nat Med. 1997 Jun;3(6):590-1. Unique Identifier : AIDSLINE MED/97319572; Karpas A; Ash S; Bainbridge D
Fighting HIV-1 with IL-16 [news; comment]: Nat Med. 1997 Jun;3(6):605-6. Unique Identifier : AIDSLINE MED/97319578; Baier M; Kurth R
Gene therapy: progress, problems, prospects [news]: Nat Med. 1997 Jun;3(6):612-3. Unique Identifier : AIDSLINE MED/97319582; Blau H; Khavari P
Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization.: Nat Med. 1997 Jun;3(6):651-8. Unique Identifier : AIDSLINE MED/97319589; Lubeck MD; Natuk R; Myagkikh M; Kalyan N; Aldrich K; Sinangil F; Alipanah S; Murthy SC; Chanda PK; Nigida SM Jr; Markham PD; Zolla-Pazner S; Steimer K; Wade M; Reitz MS Jr; Arthur LO; Mizutani S; Davis A; Hung PP; Gallo RC; Eichberg J; Robert-Guroff M; Wyeth-Ayerst Research, Radnor, PA 19087, USA.; A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequen
Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression [see comments]: Nat Med. 1997 Jun;3(6):659-64. Unique Identifier : AIDSLINE MED/97319590; Zhou P; Goldstein S; Devadas K; Tewari D; Notkins AL; Branch of Oral Infection and Immunity, National Institute of Dental; Research, National Institutes of Health, Bethesda, Maryland 20892,; USA.; Interleukin-16 (IL-16) is secreted by activated CD8+ T lymphocytes and acts on CD4+ T lymphocytes, monocytes and eosinophils. Recently, the C-terminal 130-amino acid portion of IL-16 was shown to suppress HIV-1 replication in vitro. To explore the potential of human IL-16 for gene therapy, this portion was transfected
Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase.: Nat Med. 1997 Jun;3(6):665-70. Unique Identifier : AIDSLINE MED/97319591; Grob PM; Cao Y; Muchmore E; Ho DD; Norris S; Pav JW; Shih CK; Adams J; Department of Inflammatory Diseases, Boehringer Ingelheim; Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, USA.; Chimpanzees were challenged with HIV-1IIIB while receiving a short regimen of nevirapine ( Viramune ), a nonnucleoside inhibitor of HIV-1 reverse transcriptase. The untreated, control c
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.: Nat Med. 1997 Jun;3(6):682-5. Unique Identifier : AIDSLINE MED/97319595; Melero I; Shuford WW; Newby SA; Aruffo A; Ledbetter JA; Hellstrom KE; Mittler RS; Chen L; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.; The 4-1BB glycoprotein is a member of the tumor necrosis factor receptor superfamily and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Expression of 4-1BB is restricted to primed CD4+ and CD8+ T cells, and 4-1BB signaling either by bin
A nonradioisotope approach to study the in vivo metabolism of phosphorothioate oligonucleotides.: Antisense Nucleic Acid Drug Dev. 1997 Feb;7(1):13-22. Unique Identifier : AIDSLINE MED/97207777; Cohen AS; Bourque AJ; Wang BH; Smisek DL; Belenky A; Hybridon Inc., Worcester, MA 01605, USA.; A 25-mer phosphorothioate oligodeoxynucleotide (GEM 91) complementary to the gag gene mRNA of HIV-1 virus was administered intravenously (i.v.) at a dose of 10 mg/kg/day for 8 weeks or 25 mg/kg single dose subcutaneously (SC) to adult Rhesus monkeys. No radioactive markers were used. A capillary gel electrophoresis (C
Studies on stereospecific formation of P-chiral internucleotide linkage: synthesis of all-Rp and all-Sp methylphosphonate pentanucleotide d(MMTrAPMeTPMeTPMeCPMeTAc) via Grignard activated coupling.: Antisense Nucleic Acid Drug Dev. 1997 Feb;7(1):23-30. Unique Identifier : AIDSLINE MED/97207778; Jaworska-Maslanka MM; Kacperczyk W; Korczynski D; Lesnikowski Z; Polish Academy of Sciences, Department of Bioorganic Chemistry, Lodz,; Poland.; Synthesis of stereoregular 3 ,5 -protected all-Rp and all-Sp methylphosphonate heterooligonucleotides d(MMTrAPMeTPMeTPMeCPMeTAc) (12) complementary to the fragment of HIV-1 splicing acceptor site was achieved via stereo-controlled formation of internucleotide linkage. The coupling was based on the transesterification
The increase of Hodgkin's disease incidence among young adults. Experience in Connecticut, 1935-1992.: Cancer. 1997 Jun 1;79(11):2209-18. Unique Identifier : AIDSLINE MED/97322579; Chen YT; Zheng T; Chou MC; Boyle P; Holford TR; Department of Epidemiology and Public Health, Yale University School; of Medicine, New Haven, Connecticut 06520-8025, USA.; BACKGROUND: Recent studies have indicated an increase in young adulthood Hodgkin s disease incidence, particularly among females, since 1970. However, no studies have examined the long term trends and period-cohort patterns of Hodgkin s disease incidence. METHODS: The current study reported time trends and age-period-
HIV in the brain: pathology and neurobehavioral consequences.: J Neurovirol. 1997 Apr;3(2):102-9. Unique Identifier : AIDSLINE MED/97265236; Bloom FE; Rausch DM; The Scripps Research Institute, La Jolla, California, USA.
HTLV-I associated myelopathy/tropical spastic paraparesis HAM/TSP): a chronic progressive neurologic disease associated with immunologically mediated damage to the central nervous system.: J Neurovirol. 1997 Apr;3(2):126-40. Unique Identifier : AIDSLINE MED/97265238; Levin MC; Jacobson S; Neuroimmunology Branch, National Institutes of Neurologic Disease and; Stroke, National Institutes of Health, Bethesda, Maryland 20892-1400,; USA.; This review examines information on clinical, pathological and immunological events in the slowly progressive neurologic disorder associated with the human T lymphotropic virus type-I HTLV-I) termed HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). The role of cellular immune responses to HTLV-I in
Increased cerebrospinal fluid ganglioside GM1 concentrations indicating neuronal involvement in all stages of HIV-1 infection.: J Neurovirol. 1997 Apr;3(2):148-52. Unique Identifier : AIDSLINE MED/97265240; Gisslen M; Hagberg L; Norkrans G; Lekman A; Fredman P; Department of Infectious Diseases, Goteborg University, Sweden.; Measurements of cerebrospinal fluid (CSF) concentrations of gangliosides can be used as markers of central nervous system CNS) neuronal involvement. We have analysed the CSF concentrations of the four major brain gangliosides GM1, GD1a, GD1b, and GT1b at different stages of HIV-1 infection. CSF samples were collected
Absence of the inducible form of nitric oxide synthase in the brains of patients with the acquired immunodeficiency syndrome.: J Neurovirol. 1997 Apr;3(2):153-67. Unique Identifier : AIDSLINE MED/97265241; Bagasra O; Bobroski L; Sarker A; Bagasra A; Saikumari P; Pomerantz RJ; Department of Medicine, Jefferson Medical College, Thomas Jefferson; University, Philadelphia, PA 19107, USA.; A majority of human immunodeficiency virus type I HIV-1)-infected-individuals manifest a plethora of central nervous system (CNS) diseases unrelated to opportunistic infections, including acquired immune deficiency syndrome AIDS)- dementia complex (ADC), encephalitis, and various ot
Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures.: J Neurovirol. 1997 Apr;3(2):168-73. Unique Identifier : AIDSLINE MED/97265242; New DR; Ma M; Epstein LG; Nath A; Gelbard HA; Department of Neurobiology and Anatomy, University of Rochester; Medical Center, New York 14642, USA.; Neuronal loss in HIV encephalopathy remains a mystery since HIV-1 productively infects macrophage and microglia and only rarely infects neurons in the central nervous system. Apoptosis is a mechanism which may account for the loss of neurons in HIV-1 infected brain. Putative toxic factors that result in neuronal cell
Prospects for therapy of HIV-associated neurologic diseases.: J Neurovirol. 1997 Apr;3(2):89-101. Unique Identifier : AIDSLINE MED/97265235; Sacktor N; McArthur J; Johns Hopkins University, Department of Neurology, Baltimore, MD; 21287, USA.
Kaposi's sarcoma associated herpes virus (KSHV/HHV 8): epidemiology, molecular biology and tissue distribution.: Mol Pathol. 1997 Feb;50(1):4-8. Unique Identifier : AIDSLINE MED/97340151; O'Leary JJ; Kennedy MM; McGee JO; Nuffield Department of Pathology and Bacteriology, University of; Oxford.
Impact of disseminated Mycobacterium avium-complex infection on survival of HIV-infected patients.: Eur J Med Res. 1997 Mar 24;2(3):106-10. Unique Identifier : AIDSLINE MED/97268236; Brodt HR; Enzensberger R; Kamps BS; Keul HG; Helm EB; Zentrum der Inneren Medizin, Medizinische Klinik III/Infektiologie,; Klinikum der Johann Wolfgang Goethe-Universitat, Frankfurt am Main,; Germany.; OBJECTIVE: To determine the frequency of disseminated Mycobacterium avium-complex infections (MAC) and the impact of MAC disease on overall survival in patients with HIV disease and AIDS. METHODS: Prospective study of HIV infected patients with a CD4 lymphocyte count
Combination of chemotherapy and antiviral therapy for Epstein-Barr virus-associated non-Hodgkin's lymphoma of high grade malignancy in cases of HIV infection.: Eur J Med Res. 1997 Mar 24;2(3):133-5. Unique Identifier : AIDSLINE MED/97268241; Brockmeyer NH; Pohl G; Mertins L; Department of Dermatology, University of Essen, Germany.; Two HIV patients with Epstein-Barr virus (EBV)-associated B cell lymphoma of high grade malignancy enjoyed prolonged remission after therapy with COPBLAM and the antiviral agent Acyclovir . After 3, respectively 5 cycles of treatment, the patients (stage C3 according to CDC) resp
Introducing technology into the public STD clinic.: Health Educ Behav. 1997 Feb;24(1):12-9. Unique Identifier : AIDSLINE MED/97266301; Conlon RT; Behavioral Interventions Research Branch, National Center for HIV,; STD, TB Prevention, Atlanta, Georgia, USA. roc4@cpsstd1.em.cdc.gov; Review of the literature on public health services shows that virtually no information is available on how the state-supported networks of STD clinics now function, what the possibilities are for achieving efficiency in service delivery, or the implications of local, state, and federal funding and staffing changes. Th
Using behavioral theory in computer-based health promotion and appraisal.: Health Educ Behav. 1997 Feb;24(1):20-34. Unique Identifier : AIDSLINE MED/97266302; Rhodes F; Fishbein M; Reis J; Center for Behavioral Research and Services, California State; University, Long Beach 90803, USA. frhodes@csulb.edu; This article explores how behavioral theory can facilitate the development, implementation, and evaluation of health promotion software packages intended to influence personal health practices and/or assess health risks. Current behavioral theories and models are reviewed, and their relevance to developing health prom
Computerized health assessment and education for adolescent HIV and STD prevention in health care settings and schools.: Health Educ Behav. 1997 Feb;24(1):54-70. Unique Identifier : AIDSLINE MED/97266304; Paperny DM; University of Hawaii School of Medicine, USA. paperny@hawaii.edu; This report summarizes a number of computer applications from a decade of experience with computerized adolescent health assessments and automated health education in a large health maintenance organization, military adolescent clinics, detention facilities, health fairs, and public schools. Feedback from over 5,000 a
Using an interactive computer game to increase skill and self-efficacy regarding safer sex negotiation: field test results.: Health Educ Behav. 1997 Feb;24(1):71-86. Unique Identifier : AIDSLINE MED/97266305; Thomas R; Cahill J; Santilli L; Bureau of Community Relations, New York State Department of Health,; Albany 12237-0081, USA. rpt01@health.state.ny.us; This article describes the development, field testing, and evaluation of an interactive computer program, Life Challenge, developed by the New York State Department of Health as a tool for enhancing adolescents sense of self-efficacy in HIV/AIDS prevention programs. The computer kiosks were field tested in 13 sites
Development and evaluation of a sexual decision-making and social skills program: "the choice is yours--preventing HIV/STDs".: Health Educ Behav. 1997 Feb;24(1):87-101. Unique Identifier : AIDSLINE MED/97266306; Noell J; Ary D; Duncan T; Oregon Center for Applied Science, Inc., Eugene 97403, USA.; orcas@orcasinc.com; A series of interactive videodisc programs designed to reduce HIV/STD risk behaviors was developed and evaluated. Separate programs were developed for each of three race/ethnicities African American, Hispanic, and Caucasian) at each of two age levels (middle school and high school) using extensive formative procedures
The prevalence of nipple disease among breast feeding mothers of HIV seropositive infants.: Cent Afr J Med. 1997 Jan;43(1):20-2. Unique Identifier : AIDSLINE MED/97328874; Kambarami RA; Kowo H; Department of Paediatrics and Child Health, University of Zimbabwe; Medical School, Avondale, Harare, Zimbabwe.; OBJECTIVE: To determine the prevalence of nipple disease among breast feeding mothers of symptomatic HIV seropositive infants and factors associated with nipple disease. DESIGN: Cross sectional survey. SETTING: Harare Central Hospital general paediatric wards. SUBJECTS: One hundred and four symptomatic, HIV seropositi
Hundreds enrolled in canadian HIV trials [news]: CMAJ. 1997 Jun 15;156(12):1691. Unique Identifier : AIDSLINE MED/97350777
So far so good for HIV vaccine [news]: CMAJ. 1997 Jun 15;156(12):1692. Unique Identifier : AIDSLINE MED/97342990
Bioethics for clinicians: 12. Ethical dilemmas that arise in the care of pregnant women: rethinking "maternal-fetal conflicts".: CMAJ. 1997 Jun 15;156(12):1729-32. Unique Identifier : AIDSLINE MED/97343001; Flagler E; Baylis F; Rodgers S; Office of Medical Bioethics, Faculty of Medicine, University of; Calgary, Alta.; When a pregnant woman makes a decision or acts in a manner that may be detrimental to the health and well-being of her fetus, her physician may be faced with an ethical dilemma. Is the physician s primary duty to respect the woman s autonomy, or to promote behaviour that may be in the best interest of the fetus? The c
Relationship of plasma HIV-RNA levels and levels of TNF-alpha and immune activation products in HIV infection.: Clin Immunol Immunopathol. 1997 Jul;84(1):36-45. Unique Identifier : AIDSLINE MED/97335216; Salazar-Gonzalez JF; Martinez-Maza O; Aziz N; Kolberg JA; Yeghiazarian T; Shen LP; Fahey JL; Center for Interdisciplinary Research in Immunology and Disease; CIRID), UCLA School of Medicine, Los Angeles, California 90095, USA.; The goal of this study was to determine the relationship between plasma human immunodeficiency virus (HIV) load and cytokine expression. HIV-RNA plasma levels were determined in 34 HIV-seropositive (HIV+) asymptomatic subjects [range: 0.5 to 211 kiloequivalents (kEq)/ml HIV-RNAJ, by a modified branched-DNA bDNA) assay
Immunophenotyping of T lymphocytes by three-color flow cytometry in healthy newborns, children, and adults.: Clin Immunol Immunopathol. 1997 Jul;84(1):46-55. Unique Identifier : AIDSLINE MED/97335217; McCloskey TW; Cavaliere T; Bakshi S; Harper R; Fagin J; Kohn N; Pahwa S; Division of Allergy/Immunology, North Shore University Hospital, New; York University School of Medicine, Manhasset 11030, USA.; Reagents are now available which allow simultaneous assessment of three different fluorescence wave-lengths on most commercially available flow cytometers. Such three-color analyses provide more information than single- or dual-color analyses. The present study was undertaken in order to establish age-related differen
Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin.: Clin Immunol Immunopathol. 1997 Jul;84(1):85-94. Unique Identifier : AIDSLINE MED/97335221; Zhu J; Bai XF; Mix E; Link H; Division of Neurology, Karolinska Institute, Huddinge University; Hospital, Stockholm, Sweden.; Experimental autoimmune neuritis (EAN) is a T-cell-mediated autoimmune disease of the peripheral nervous system (PNS) that can be actively induced in Lewis rats by immunization with bovine PNS myelin and Freund s complete adjuvant. EAN is used as an animal model of the Guillain-Barre syndrome (GBS) in humans. To study
AZT induces high frequency, rapid amplification of centromeric DNA.: Cytogenet Cell Genet. 1997;76(3-4):128-33. Unique Identifier : AIDSLINE MED/97330046; Parra I; Flores C; Adrian D; Windle B; Cancer Therapy and Research Center, San Antonio, TX 78229, USA.; The reverse transcriptase inhibitor 3 -azido-deoxythymidine ( AZT ) has previously been shown to be incorporated into specific regions near the telomeres and centromeres of Chinese hamster ovary cell chromosomes. Our investigation of the effects of AZT
A 31-year-old man with a thick-walled cyst.: Chest. 1997 Jun;111(6):1754-6. Unique Identifier : AIDSLINE MED/97330745; Lando Y; Criner GJ; Division of Pulmonary and Critical Care Medicine, Temple University; School of Medicine, Philadelphia, USA.
Malignant thymoma in a patient with HIV positivity: a case report with a review of the differential cytologic diagnoses.: Diagn Cytopathol. 1997 Mar;16(3):267-9. Unique Identifier : AIDSLINE MED/97254316; Fiorella RM; Lavin M; Dubey S; Kragel PJ; Department of Pathology, Truman Medical Center, Kansas City, MO 64118,; USA.; A 33-yr-old African-American male with known human immunodeficiency virus (HIV) positivity underwent CT guided fine-needle aspiration biopsy of an anterior mediastinal mass. The aspirate was composed of a dimorphic population of cells that included small mature lymphoid cells and scattered cohesive groups of large epi
[Auxiliary liver transplantation for acute liver failure after intake of 3,4-methylenedioxymethamphetamine ("Ecstasy")]: Dtsch Med Wochenschr. 1997 May 30;122(22):716-20. Unique Identifier : AIDSLINE MED/97344689; Hellinger A; Rauen U; de Groot H; Erhard J; Abteilung fur Allgemeine Chirurgie, Universitat Essen.; HISTORY AND CLINICAL FINDINGS: An 18-year-old patient had for 6 days been suffering from right upper abdominal pain, weight loss, vomiting and yellow discoloration of the skin. For the preceding 8 months he had been regularly taking 1-2 tablets of ecstasy 3,4-methylenedioxymethamphetamine--MDMA) per week, the last 8
Zimbabwean teenagers' knowledge of AIDS and other sexually transmitted diseases.: East Afr Med J. 1997 Feb;74(2):76-81. Unique Identifier : AIDSLINE MED/97328888; Kasule J; Mbizvo MT; Gupta V; Fusakaniko S; Mwateba R; Mpanju-Shumbusho W; Kinoti SH; Padachy J; Department of Obstetrics and Gynaecology, University of Zimbabwe.; A cross sectional anonymously administered questionnaire was used amongst 1689 secondary school girls and boys to determine their knowledge of AIDS and other sexually transmitted diseases (STDs). Their knowledge was found to be very low. While 80% could name an STD in an open question, only 16% could recognise the imp
An artificial HIV enhancer-binding peptide is dimerized by the addition of a leucine zipper.: Eur Biophys J. 1997;25(5-6):399-403. Unique Identifier : AIDSLINE MED/97331855; Liu N; Caderas G; Gutte B; Thomas RM; Biochemisches Institut, Universitat Zurich.; A 42 residue artificial peptide that binds to the HIV-1 enhancers has been described previously. The specificity of interaction of the peptide with its target DNA sequence has been demonstrated by a variety of techniques. Naturally occurring regulatory proteins frequently bind to DNA as dimers, thereby increasing the
HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.: EMBO J. 1997 May 15;16(10):2599-609. Unique Identifier : AIDSLINE MED/97327540; Bieniasz PD; Fridell RA; Aramori I; Ferguson SS; Caron MG; Cullen BR; Howard Hughes Medical Institute, Department of Genetics, Duke; University Medical Center, Durham, NC 27710, USA.; Although the human hCCR-5 chemokine receptor can serve as a co-receptor for both M-tropic (ADA and BaL) and dual-tropic 89.6) strains of human immunodeficiency virus type 1 (HIV-1), the closely related mouse mCCR-5 homolog is inactive. We used chimeric hCCR-5-mCCR-5 receptor molecules to examine the functional importa
Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.: EMBO J. 1997 May 15;16(10):2836-50. Unique Identifier : AIDSLINE MED/97327561; Garcia-Martinez LF; Mavankal G; Neveu JM; Lane WS; Ivanov D; Gaynor RB; Department of Medicine, University of Texas Southwestern Medical; Center, Dallas 75235-8594, USA.; The Tat protein is a transcriptional activator which is required for efficient human immunodeficiency virus 1 (HIV-1) gene expression Tat stimulates HIV-1 transcriptional elongation by increasing the processivity of RNA polymerase II. To address whether Tat-mediated effects on HIV-1 gene expression are due to modulati
The GTPase Rho has a critical regulatory role in thymus development.: EMBO J. 1997 May 1;16(9):2397-407. Unique Identifier : AIDSLINE MED/97315179; Henning SW; Galandrini R; Hall A; Cantrell DA; Lymphocyte Activation Laboratory, Imperial Cancer Research Fund,; London, UK. henning@europa.lif.icnet.uk; The present study employs a genetic approach to explore the role of Rho GTPases in murine thymic development. Inactivation of Rho function in the thymus was achieved by thymic targeting of a transgene encoding C3 transferase from Clostridium botulinum which selectively ADP-ribosylates Rho within its effector domain an
Stable co-occupancy of transcription factors and histones at the HIV-1 enhancer.: EMBO J. 1997 May 1;16(9):2463-72. Unique Identifier : AIDSLINE MED/97315185; Steger DJ; Workman JL; Department of Biochemistry and Molecular Biology, The Center for Gene; Regulation, The Pennsylvania State University, University Park; 16802-4500, USA.; To investigate mechanisms yielding DNase I-hypersensitive sites DHSs) at gene regulatory regions, we have initiated a biochemical analysis of transcription factor binding and nucleosome remodeling with a region of the human immunodeficiency virus 1 (HIV-1) 5 long terminal repeat (LTR) that harbors constitutive DHSs i
Structure/function relationship study of Tyr14 and Arg22 in trichosanthin, a ribosome-inactivating protein.: Eur J Biochem. 1997 Apr 15;245(2):423-7. Unique Identifier : AIDSLINE MED/97296410; Shaw PC; Mulot S; Ma SK; Xu QF; Yao HB; Wu S; Lu XH; Dong YC; Department of Biochemistry, The Chinese University of Hong Kong,; Shatin.; Amino acids Tyr14 and Arg22 in trichosanthin are residues on helix A1 close to the active-site cleft. They are invariant in various type-I and type-II ribosome-inactivating proteins. In this study, Tyr14 was changed to Phe and Arg22 to Lys and Leu. Modified proteins were purified, and activities compared by assaying t
Detection of Aspergillus DNA in bronchoalveolar lavage fluid of AIDS patients by the polymerase chain reaction [letter]: Eur J Clin Microbiol Infect Dis. 1997 Jan;16(1):24-5. Unique Identifier : AIDSLINE MED/97217709; Bart-Delabesse E; Marmorat-Khuong A; Costa JM; Dubreuil-Lemaire ML; Bretagne S
Indium-111 labelled lymphocytes: isotope distribution and cell division.: Eur J Nucl Med. 1997 May;24(5):488-96. Unique Identifier : AIDSLINE MED/97287897; Kuyama J; McCormack A; George AJ; Heelan BT; Osman S; Batchelor JR; Peters AM; Department of Radiology, Royal Postgraduate Medical School, London,; UK.; Since lymphocytes continue to proliferate and divide in vivo, it is important to determine the fate of a radionulide following lymphocyte labelling. Using the mixed lymphocyte reaction (MLR), we induced indium-111 labelled lymphocytes from a specific in-bred rat strain (AS) to divide and then observed the subsequent 1
Viral load and syncytium inducing HIV-1 variants indicate progression of perinatal HIV-infection [letter]: Eur J Pediatr. 1997 Apr;156(4):339. Unique Identifier : AIDSLINE MED/97274828; Funk M; Mentzer D; Klarmann D; Cinatl J; Kreuz W; Kornhuber B
The activation domain of a hormone inducible HTLV-1 Rex protein determines colocalization with the nuclear pore.: Exp Cell Res. 1997 Jun 15;233(2):363-71. Unique Identifier : AIDSLINE MED/97337804; Rehberger S; Gounari F; DucDodon M; Chlichlia K; Gazzolo L; Schirrmacher V; Khazaie K; Department of Tumour Immunology, German Cancer Research Centre,; Heidelberg.; Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) Rex is an essential regulatory protein that acts at the posttranscriptional level to promote expression of unspliced and singly spliced genes of the virus. Rex functions have been attributed to at least three separate domains of the protein determining nuclear/nucle
Production of env-deficient rous sarcoma virus (RSV) early after infection.: Folia Biol (Praha). 1997;43(2):63-70. Unique Identifier : AIDSLINE MED/97302706; Hara H; Park HT; Fujihara M; Kaji A; Department of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia 19104, USA.; Production of defective virus particles during the early stage of Rous sarcoma virus (RSV) infection of chicken embryo fibroblasts CEF) was examined. RSV harvested 2 days post infection (2pi) had 10 to 30 times lower specific infectivity (focus forming units/unit reverse transcriptase activity) than 5pi harvest. Virus
Multifunctional activities of human fibroblast 34-kDa hyaluronic acid-binding protein.: Gene. 1997 Apr 29;190(1):223-5. Unique Identifier : AIDSLINE MED/97329358; Das S; Deb TB; Kumar R; Datta K; Biochemistry Laboratory, School of Environmental Sciences, Jawaharlal; Nehru University, New Delhi, India.; We have already reported that human fibroblast 34-kDa hyaluronic acid-binding protein (HABP) is identical with P32, the protein co-purified with splicing factor SF-2 [Deb and Datta (1996) J. Biol. Chem. 271, 2206-2212]. Data search further revealed that it has 92% sequence homology with a murine protein YL2 which inte
Human immunodeficiency virus type-1 p24 sequence from an Indian strain: expression in Escherichia coli and implications in diagnostics.: Gene. 1997 Apr 29;190(1):27-30. Unique Identifier : AIDSLINE MED/97329332; Gupta SK; Sengupta J; Bisht R; Bhatnagar A; Kaul R; Gamete Antigen Laboratory, National Institute of Immunology, New; Delhi, India. GA@nii.ernet.in; A 637-bp fragment, corresponding to the p24 human immunodeficiency virus (HIV) core protein from the gag ORF, was PCR amplified from DNA isolated from peripheral blood mononuclear lymphocytes (PBML) of an asymptomatic HIV-1 seropositive human subject from Bombay and cloned into PCRScript SK(+). The nucleotide sequence
Hepatitis B virus infection and liver transplantation.: Gut. 1997 May;40(5):568-71. Unique Identifier : AIDSLINE MED/97347863; Terrault NA; Wright TL; Veterans Administration Medical Center, San Francisco, CA 94121, USA.
Addressing AIDS long-term care issues through education and advocacy.: Health Soc Work. 1995 Feb;20(1):75-80. Unique Identifier : AIDSLINE MED/97299027; Marder R; Linsk NL; Northwestern University Medical School, Chicago, IL, USA.
In the aftermath: serial crisis intervention for people with HIV.: Health Soc Work. 1997 May;22(2):125-32. Unique Identifier : AIDSLINE MED/97278025; Poindexter CC; Jane Addams School of Social Work, University of Illinois at Chicago; 60626, USA.; Because the ever-changing course of HIV disease, including AIDS, represents a continuous series of unexpected stressors, repeated crisis intervention is appropriate for people who are HIV infected. HIV disease causes situational, developmental, social, and compound crises. People with HIV may experience episodic traum
Microsatellite instability in KSHV/HHV-8 positive body-cavity-based lymphoma.: Hum Pathol. 1997 Jun;28(6):748-50. Unique Identifier : AIDSLINE MED/97334315; Gaidano G; Pastore C; Gloghini A; Capello D; Tirelli U; Saglio G; Carbone A; Dipartimento di Scienze Mediche, Universita di Torino, Italy.; Body-cavity-based lymphoma (BCBL) is a rare non-Hodgkin- s lymphoma (NHL) type growing in liquid phase in the body cavities. Virtually all BCBL associate with Kaposi s sarcoma-associated herpesvirus/human herpesvirus type-8 infection in the absence of molecular alterations typical of other NHL categories. Microsatelli
Co-development of naive CD4+ cells towards T helper type 1 or T helper type 2 cells induced by a combination of IL-12 and IL-4.: Immunobiology. 1996-97;196(5):475-84. Unique Identifier : AIDSLINE MED/97290679; Palm N; Germann T; Goedert S; Hoehn P; Koelsch S; Rude E; Schmitt E; Institute of Immunology, Johannes Gutenberg University, Mainz,; Germany.; Cytokines were found to play a key role in Th cell differentiation. Among them IL-12 was shown to be a potent differentiation factor for Th1 cells, whereas IL-4 is the only known cytokine that promotes the development of Th2 cells. Upon addition of comparable amounts of IL-4 and IL-12 to a primary culture of naive CD4
Characterization of T cells transmigrating through human endothelial cells in patients with HTLV-I-associated myelopathy.: Immunobiology. 1996-97;196(5):485-90. Unique Identifier : AIDSLINE MED/97290680; Ichinose K; Nakamura T; Nishiura Y; Tsujino A; Goto H; Shirabe S; Furuya T; Nagataki S; First Department of Internal Medicine, Nagasaki University School of; Medicine, Japan.; We investigated the surface markers as well as the expression of beta 2-integrin (LFA-1 beta/CD 18), in T cells migrating through human umbilical vein endothelial cells (EC) in patients with HTLV-I-associated myelopathy (HAM). No significant differences were found in the percentages of both HLA-DR+ T cells and total C
Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanism.: Immunology. 1997 May;91(1):28-34. Unique Identifier : AIDSLINE MED/97347895; Horiuchi S; Koyanagi Y; Tanaka Y; Waki M; Matsumoto A; Zhou YW; Yamamoto M; Yamamoto N; Department of Microbiology, Faculty of Medicine, Tokyo Medical and; Dental University, Japan.; A polymerase chain reaction (PCR) method was used to detect the interleukin-2 receptor alpha-chain (IL-2R alpha) chain which lacks the conventional transmembrane (TM) domain in mRNA from human T-cell leukaemia virus type-I (HTLV-I)-infected cell lines or peripheral blood mononuclear cells (PBMC) isolated from adult T-
Reconstitution of SCID mice with haemopoietic precursors: a detailed analysis of gamma delta T-cell reconstitution.: Immunology. 1997 May;91(1):65-72. Unique Identifier : AIDSLINE MED/97347900; Kelly KA; O'Brien R; Born W; National Jewish Centre for Immunology and Respiratory Medicine,; University of Colorado Health Sciences Centre, Denver, USA.; A well-known characteristic of gamma delta T cells is that they are produced in waves during ontogeny, with cells expressing T-cell receptor V gamma 5 appearing early in fetal thymic ontogeny, followed by V gamma 6, then by other gamma delta T-cell types. In addition, evidence exists to suggest that the potential of h
CD45 enhances positive selection and is expressed at a high level in large, cycling, positively selected CD4+CD8+ thymocytes.: Immunology. 1997 May;91(1):95-103. Unique Identifier : AIDSLINE MED/97347904; Ong CJ; Dutz JP; Chui D; Teh HS; Marth JD; Biomedical Research Centre, University of British Columbia, Vancouver,; Canada.; T-cell development is arrested at the CD4+CD8+ (DP; double-positive) stage of thymocyte development in CD45 null mice. However, the mechanism by which CD45 participates in the positive selection of T cells remains to be investigated. In this report we describe a DP thymocyte population that associates positive selecti
Primary cytotoxicity of SEB-activated human PBMC and separated CD8+ and CD4+ T lymphocytes elicited by two different stimulation protocols.: Immunol Cell Biol. 1996 Dec;74(6):483-9. Unique Identifier : AIDSLINE MED/97143574; Seprenyi G; Abe J; Kohsaka T; National Medical Children's Medical Research Center, Tokyo, Japan.; The primary cytotoxicity of Staphylococcal enterotoxin B SEB)-stimulated PBMC and separated CD8+ and CD4+ T cells against Burkitt s lymphoma target cells has been characterized by applying two stimulation protocols. In the bulk protocol, the PBMC were stimulated with 100 ng/mL SEB for 3 days before separation to CD4+
Epidemiological features of acquired immunodeficiency syndrome in southern India.: Indian J Med Res. 1997 May;105:191-7. Unique Identifier : AIDSLINE MED/97326206; Srikanth P; John TJ; Jeyakumari H; Babu PG; Mathai D; Jacob M; Cherian AM; Ganesh A; Zachariah A; Department of Medicine, Christian Medical College & Hospital, Vellore.; AIDS was diagnosed in 187 men and 24 women (M:F = 8:1) from April 1987 till December 1994 at the Christian Medical College Hospital, Vellore. The doubling time of the occurrence of AIDS cases was 14 months; during 1987-90 there were an average of 5.7 cases per year; in 1991-93 there were 28 per year; in 1994 there wer
A randomized comparison of two clarithromycin doses for treatment of Mycobacterium avium complex infections.: Infection. 1997 Jan-Feb;25(1):16-21. Unique Identifier : AIDSLINE MED/97191586; Dautzenberg B; Truffot-Pernot C; Hazebroucq J; Legris S; Guerin C; Begelman C; Guermonprez G; Fievet MH; Chastang C; Grosset J; Service de Pneumologie, Groupe Hopitalier Pitie-Salpetriere, Paris,; France.; Two dosages of clarithromycin were compared for treatment of disseminated Mycobacterium avium disease of AIDS patients: high-dose (HD): 1,000 mg or 750 mg b.i.d. according to body weight, and low-dose (LD): 1,000 mg or 750 mg q.d. Patients with high probability of M. avium positive blood culture on day 0 received a 42
Zidovudine and thymus humoral factor gamma-2 in the treatment of HIV infection: preliminary clinical experience.: Infection. 1997 Jan-Feb;25(1):35-8. Unique Identifier : AIDSLINE MED/97191590; Maggiolo F; Taras A; Pravettoni MG; Leone M; Ingrosso A; Suter F; Div. of Infectious Diseases, General Hospital, Busto Arsizio, Italy.; A case-control, prospective, open-label, clinical trial to evaluate efficacy and safety of a combined zidovudine/Thymus Humoral Factor Gamma-2 (THF) therapy in HIV-infected subjects was conducted in 13 patients. Twenty-six patients were included as controls receiving only zidovudine. The two groups of patients were ma
Epidemiological and clinical aspects of mycobacterial infections.: Infection. 1997 Jan-Feb;25(1):56-9. Unique Identifier : AIDSLINE MED/97191598; Opravil M; Division of Infectious Diseases and Hospital Epidemiology, University; Hospital, Zurich, Switzerland.; The incidence of tuberculosis in the developed countries has recently started to rise again due to increased migration, a higher rate of direct transmission of Mycobacterium tuberculosis, and co-infection with HIV. The impact of the latter on the pathogenesis and presentation of tuberculosis is summarised. Important m
The use of rifabutin in Europe for the treatment of mycobacterial infection in AIDS patients.: Infection. 1997 Jan-Feb;25(1):63-6. Unique Identifier : AIDSLINE MED/97191600; Dautzenberg B; Service de pneumologie Groupe Hospitalier Pitie-Salpetriere, Paris,; France.; The MICs of rifabutin on Mycobacterium avium are compatible with its efficacy in clinical infections. Two North American trials established the prophylactic effect of rifabutin in disseminated M. avium disease in AIDS patients. Several prospective non-randomized trials show the clinical and bacteriological efficacy of
Prophylaxis against Mycobacterium avium-intracellulare complex infections in human immunodeficiency virus-infected patients.: Infection. 1997 Jan-Feb;25(1):67-70. Unique Identifier : AIDSLINE MED/97191601; Nightingale SD; Infection due to the Mycobacterium avium complex (MAC) accounts for the most frequent AIDS-related opportunistic infections, but MAC infection is usually not the first AIDS-defining event that a patient infected with HIV experiences. The incidence increases linearly over time, at a rate of 20 to 25% per year, after a
Differences in the recognition of tumor-specific CD8+ T cells derived from solid tumor, metastatic lymph nodes and ascites in patients with gastric cancer.: Int J Cancer. 1997 Jun 11;71(6):978-81. Unique Identifier : AIDSLINE MED/97329187; Kono K; Ichihara F; Iizuka H; Sekikawa T; Matsumoto Y; First Department of Surgery, Yamanashi Medical University, Japan.; kojikono@res.yamanashi-med.ac.jp; We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph n
Immune response to the cestode Hymenolepis nana: cytokine production during infection with eggs or cysts.: Int J Parasitol. 1997 Mar;27(3):321-7. Unique Identifier : AIDSLINE MED/97283959; Conchedda M; Bortoletti G; Gabriele F; Wakelin D; Palmas C; Sezione di Parassitologia, Universita degli Studi di Cagliari, Italy.; Analysis of cytokine production (IFN-gamma, IL-2 , IL-3, IL-4, IL-5) by in vitro Con A-stimulated mesenteric lymph node cells measured daily after egg or cyst infection of mice with Hymenolepis nana showed that cytokine production varies during parasite development and
The fight against AIDS.: Isr J Med Sci. 1997 Jan;33(1):80. Unique Identifier : AIDSLINE MED/97355502; Shafrir E; Hebrew University - Hadassah Medical School, Jerusalem, Israel.
Localized frameshift mutation generates selective, high-frequency phase variation of a surface lipoprotein encoded by a mycoplasma ABC transporter operon.: J Bacteriol. 1997 Jun;179(12):4013-22. Unique Identifier : AIDSLINE MED/97334122; Theiss P; Wise KS; Department of Molecular Microbiology and Immunology, School of; Medicine, University of Missouri-Columbia, 65212, USA.; The wall-less mycoplasmas have revealed unusual microbial strategies for adaptive variation of antigenic membrane proteins exposed during their surface colonization of host cells. In particular, high-frequency mutations affecting the expression of selected surface lipoproteins have been increasingly documented for thi
Prevalence of Bartonella henselae and Bartonella clarridgeiae in stray cats.: J Clin Microbiol. 1997 Jun;35(6):1327-31. Unique Identifier : AIDSLINE MED/97305970; Heller R; Artois M; Xemar V; De Briel D; Gehin H; Jaulhac B; Monteil H; Piemont Y; Institut de Bacteriologie, Faculte de Medecine, Universite Louis; Pasteur, Strasbourg, France.; The aim of the present work was to determine by blood culture the prevalence of blood infection with Bartonella species in a well-defined, European, urban stray cat population. Therefore, 94 stray cats were trapped from 10 cat colonies. Blood samples of these cats were cultured on both blood agar and liquid medium in
Genetic characterization of multidrug-resistant Mycobacterium bovis strains from a hospital outbreak involving human immunodeficiency virus-positive patients.: J Clin Microbiol. 1997 Jun;35(6):1390-3. Unique Identifier : AIDSLINE MED/97305982; Blazquez J; Espinosa de Los Monteros LE; Samper S; Martin C; Guerrero A; Cobo J; Van Embden J; Baquero F; Gomez-Mampaso E; Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain.; jesus.blazquez@hrc.es; Nineteen multidrug-resistant (MDR) Mycobacterium complex strains isolated in a nosocomial outbreak were characterized at the molecular level. The strains were microbiologically characterized as Mycobacterium bovis. The mpt40 sequence was not present in chromosomal DNA from these strains, supporting the fact that they
Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis.: J Clin Microbiol. 1997 Jun;35(6):1411-4. Unique Identifier : AIDSLINE MED/97305986; Howe DK; Honore S; Derouin F; Sibley LD; Department of Molecular Microbiology, Washington University School of; Medicine, St. Louis, Missouri 63110, USA.; To determine the genotypes of Toxoplasma gondii strains associated with human toxoplasmosis, we developed a sensitive approach for typing parasites grown from clinical samples by short-term in vitro culture. A newly described nested PCR assay was capable of amplifying genomic DNA from as few as five parasites in the p
Usefulness of PCR for diagnosis of Pneumocystis carinii pneumonia in different patient groups.: J Clin Microbiol. 1997 Jun;35(6):1445-9. Unique Identifier : AIDSLINE MED/97305991; Weig M; Klinker H; Bogner BH; Meier A; Gross U; Institute for Hygiene and Microbiology, University of Wurzburg,; Germany. mweig@hygiene.uni-wuerzburg.de; Pneumocystis carinii pneumonia (PCP) is one of the most predominant opportunistic infectious diseases in patients with AIDS. Nested PCR has been described as a sensitive and specific tool for detecting P. carinii DNA in clinical specimens. Little is known about the correlation of positive PCR results and clinical evid
Multiplex PCR assay for immediate identification of the infecting species in patients with mycobacterial disease.: J Clin Microbiol. 1997 Jun;35(6):1492-8. Unique Identifier : AIDSLINE MED/97306000; Kox LF; Jansen HM; Kuijper S; Kolk AH; Department of Biomedical Research, Royal Tropical Institute, Academic; Medical Centre, Amsterdam, The Netherlands.; Rapid identification of infecting mycobacterial species enables appropriate medical care decisions to be made. Our aim was to demonstrate the clinical usefulness of the multiplex PCR assay, a test based on PCR, which permits direct identification of 12 mycobacterial species in clinical specimens. A total of 259 specim
Rapid discrimination of Mycobacterium avium strains from AIDS patients by randomly amplified polymorphic DNA analysis.: J Clin Microbiol. 1997 Jun;35(6):1585-8. Unique Identifier : AIDSLINE MED/97306020; Matsiota-Bernard P; Waser S; Tassios PT; Kyriakopoulos A; Legakis NJ; Laboratoire de Microbiologie, Hopital Raymond Poincare, Garches,; France.; A randomly amplified polymorphic DNA (RAPD) analysis was performed for the molecular typing of Mycobacterium avium strains. This method was applied to epidemiologically unrelated M. avium strains isolated from the blood of 10 different AIDS patients and to strains that were considered epidemiologically related, as the
Detection of Pneumocystis carinii in respiratory specimens by PCR-solution hybridization enzyme-linked immunoassay.: J Clin Microbiol. 1997 Jun;35(6):1589-91. Unique Identifier : AIDSLINE MED/97306021; Ortona E; Margutti P; Tamburrini E; Mencarini P; Visconti E; Zolfo M; Siracusano A; Department of Immunology, Istituto Superiore di Sanita, Rome, Italy.; By using a recently developed PCR-solution hybridization enzyme-linked assay (PCR-SHELA), we investigated Pneumocystis carinii in bronchoalveolar lavage fluid samples and induced sputa of patients with pneumocystosis. In detecting P. carinii, PCR-SHELA proved more sensitive than immunofluorescence staining or a single
Detection of human Betaherpesvirinae in saliva and urine from immunocompromised and immunocompetent subjects.: J Clin Microbiol. 1997 Jun;35(6):1600-3. Unique Identifier : AIDSLINE MED/97306025; Gautheret-Dejean A; Aubin JT; Poirel L; Huraux JM; Nicolas JC; Rozenbaum W; Agut H; Laboratoire de Virologie, CNRS EP 57, CERVI, Groupe Hospitalier; Pitie-Salpetriere, Paris, France.; Human cytomegalovirus (HCMV) is a well-known opportunistic agent that reactivates in human immunodeficiency virus HIV)-seropositive subjects. Human herpesvirus 6 (HHV-6) and HHV-7 were discovered recently and, like HCMV, belong to the Betaherpesvirinae subfamily. We looked for the
Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders.: J Clin Microbiol. 1997 Jun;35(6):1612-5. Unique Identifier : AIDSLINE MED/97306029; Rowe DT; Qu L; Reyes J; Jabbour N; Yunis E; Putnam P; Todo S; Green M; Department of Infectious Diseases and Microbiology, Graduate School of; Public Health, The Childrens Hospital of Pittsburgh, Pennsylvania; 15261, USA.; A quantitative competitive PCR (QC-PCR) assay for Epstein-Barr virus (EBV) has been developed to provide accurate measurement of EBV genome load in pediatric transplant recipients at risk for developing posttransplant lymphoproliferative disorder (PTLD). The assay quantifies between 8 and 5,000 copies of the EBV genom
Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP HTLV-I-associated myelopathy/tropical spastic paraparesis).: J Neuroimmunol. 1997 Jun;76(1-2):50-60. Unique Identifier : AIDSLINE MED/97328074; Yamano Y; Kitze B; Yashiki S; Usuku K; Fujiyoshi T; Kaminagayoshi T; Unoki K; Izumo S; Osame M; Sonoda S; Third Department of Internal Medicine, Kagoshima University, Japan.; To determine CD4+ T-cell epitopes of HTLV-I-envelope protein recognized by the HLA alleles associated with HAM/TSP, we established 20 CD4+ T-cell lines from peripheral blood mononuclear cells (PBMCs) of naive healthy donors using a panel of synthetic peptides spanning the entire length of HTLV-I-envelope proteins, gp4
Impact of a school-based prevention programme on traditional and egalitarian adolescents' safer sex intentions.: J Adolesc. 1997 Apr;20(2):177-88. Unique Identifier : AIDSLINE MED/97258179; Buysse A; Van Oost P; University of Ghent, Research Group Health and Behaviour, Belgium.; The study assessed the impact of a school-based sexual risk reduction program on adolescent s knowledge, need for information, problem-solving and communications skills, intention to talk about and to practise safer sex. The primary goal of working with adolescents in schools was successful, in that significant treatm
The role of family processes and coping strategies in the relationship between parental chronic illness and childhood internalizing problems.: J Abnorm Child Psychol. 1997 Apr;25(2):83-94. Unique Identifier : AIDSLINE MED/97262817; Steele RG; Forehand R; Armistead L; University of Georgia, Athens 30602, USA.; Sixty-nine families (father, mother, and one child) in which the father had hemophilia, approximately half of whom were HIV positive, were assessed in an examination of the relationship between parental chronic illness, family functioning, child coping strategies, and child adjustment. Latent variable path analyses wi
IL-2 induces Fas ligand/Fas (CD95L/CD95) cytotoxicity in CD8+ and CD4+ T lymphocyte clones.: J Immunol. 1997 Jun 15;158(12):5612-8. Unique Identifier : AIDSLINE MED/97334211; Esser MT; Dinglasan RD; Krishnamurthy B; Gullo CA; Graham MB; Braciale VL; Department of Microbiology and the Beirne B. Carter Center for; Immunology Research, University of Virginia Health Sciences Center,; Charlottesville 22908, USA.; IL-2 is a T cell growth factor that has pleiotropic functions in T cell differentiation, induction of lymphokine-activated killer cells, and regulation of immune responses. In studying TCR triggering of perforin or Fas ligand (FasL)/Fas (CD95 ligand/CD95) cytotoxicity
Streptococcal preparation OK-432 is a potent inducer of IL-12 and a T helper cell 1 dominant state.: J Immunol. 1997 Jun 15;158(12):5619-26. Unique Identifier : AIDSLINE MED/97334212; Fujimoto T; Duda RB; Szilvasi A; Chen X; Mai M; O'Donnell MA; Division of Urology, Beth Israel Deaconess Medical Center, Harvard; Medical School, Boston, MA 02215, USA.; Streptococcal preparation OK-432 is a bacterial immunopotentiator extensively used in Japan for adjuvant cancer therapy. Using a C57BL/6 mouse model, OK-432 was found to induce multiple cytokines including the Th1 polarizing cytokine IL-12. Expression of IL-12 protein by murine sple
Induction of human T helper cell type 1 differentiation results in loss of IFN-gamma receptor beta-chain expression.: J Immunol. 1997 Jun 15;158(12):5627-31. Unique Identifier : AIDSLINE MED/97334213; Groux H; Sornasse T; Cottrez F; de Vries JE; Coffman RL; Roncarolo MG; Yssel H; Department of Human Immunology, DNAX Research Institute, Palo Alto, CA; 94304, USA.; Differential expression of cytokine receptors accounts for an important regulatory mechanism in differentiation of Th1/Th2 subsets. Here, we report that human Th0 and Th2 clones constitutively express transcripts for the IFN-gammaR beta-chain, whereas mRNA for this signaling component of the IFN-gamma receptor is abse
Involvement of IL-4-producing Vbeta8.2+ CD4+ CD62L- CD45RB- T cells in non-MHC gene-controlled predisposition toward skewing into T helper type-2 immunity in BALB/c mice.: J Immunol. 1997 Jun 15;158(12):5698-706. Unique Identifier : AIDSLINE MED/97334222; Nishimura T; Santa K; Yahata T; Sato N; Ohta A; Ohmi Y; Sato T; Hozumi K; Habu S; Department of Immunology, Tokai University School of Medicine,; Bohseidai, Isehara, Japan.; It was found that freshly isolated BALB/c CD4+ T cells produced high levels of IL-4 and IL-10 in response to immobilized anti-CD3 mAb, while C57BL/6 CD4+ T cells produced low amounts of IL-4 and IL-10. The high IL-4-producing ability of BALB/c mice was demonstrated to be genetically dominant and it was controlled by n
Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity.: J Immunol. 1997 Jun 15;158(12):5707-16. Unique Identifier : AIDSLINE MED/97334223; Ohoka Y; Kuwata T; Asada A; Zhao Y; Mukai M; Iwata M; Project Research Center, Mitsubishi Kasei Institute of Life Sciences,; Machida-shi, Tokyo, Japan.; Thymocyte-positive selection involves signaling through TCR and accessory molecules, and the signaling intensity appears to be critical for this event. The specific inhibitor of classical Ca2+-dependent protein kinase C (cPKC), Go 6976, inhibited positive selection in fetal thymus organ culture, indicating that cPKC a
Adoptive transfer of gut intraepithelial lymphocytes protects against murine infection with Toxoplasma gondii.: J Immunol. 1997 Jun 15;158(12):5883-9. Unique Identifier : AIDSLINE MED/97334244; Buzoni-Gatel D; Lepage AC; Dimier-Poisson IH; Bout DT; Kasper LH; Immunology of Infectious Diseases (CJF INSERM 93-09), Equipe associee; INRA (Institut National de la Recherche Agronomique) d'Immunologie; Parasitaire, Tours, France. buzoni@balzac.univ-tours.fr; Intraepithelial lymphocytes (IEL) of the gut represent a primary immune barrier against infection by orally acquired pathogens. Naturally acquired infection with Toxoplasma gondii induces the proliferation of CD8+ T cells in both the gut and spleen. Gut-derived CD8alpha/beta+ IEL exhibit MHC-restricted cytotoxicity ag
B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.: J Immunol. 1997 Jun 15;158(12):5914-20. Unique Identifier : AIDSLINE MED/97334247; Subramanian G; Kazura JW; Pearlman E; Jia X; Malhotra I; King CL; Department of Medicine, Case Western Reserve University School of; Medicine, Cleveland, OH 44106, USA.; B7 ligands on APCs engage CD28/CTLA4 counter-receptors on T cells critical for T lymphocyte activation and functional differentiation of T helper subsets. To examine whether the ligands B7-1 (CD80) and B7-2 (CD86) affect gene expression of Th2 cytokines and development of Th2-mediated pathologic tissue reactions, mice
Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection.: J Immunol. 1997 Jun 15;158(12):5921-6. Unique Identifier : AIDSLINE MED/97334248; Zhu X; Venkataprasad N; Thangaraj HS; Hill M; Singh M; Ivanyi J; Vordermeier HM; Medical Research Council Clinical Sciences Centre, Tuberculosis &; Related Infections Unit, Hammersmith Hospital, London, United Kingdom.; The 38-kDa glycolipoprotein of Mycobacterium tuberculosis has been known to evoke prominent T cell and Ab responses in patients with active tuberculosis. In this study, we investigated its protective capacity using plasmid DNA immunization in a mouse experimental model. Prior knowledge of several antigenic determinant
Transendothelial migration of lymphocytes from HIV-1-infected donors: a mechanism for extravascular dissemination of HIV-1.: J Immunol. 1997 Jun 15;158(12):5968-77. Unique Identifier : AIDSLINE MED/97334254; Birdsall HH; Trial J; Lin HJ; Green DM; Sorrentino GW; Siwak EB; de Jong AL; Rossen RD; Research Center for AIDS and HIV Infections, the Immunology Research; Laboratory at the Veterans Affairs Medical Center, Baylor College of; Medicine, Houston, TX 77030, USA. birdsall@bcm.tmc.edu; To identify factors that cause HIV-1 to establish perivascular foci of infected cells, we studied the transendothelial migration of blood mononuclear leukocytes (MNL) from 76 HIV+ patients and 41 controls. The fraction of patients lymphocytes that migrated across endothelial cell monolayers in vitro was significantly
IL-15 enhances immune functions during HIV infection.: J Immunol. 1997 Jun 15;158(12):5978-87. Unique Identifier : AIDSLINE MED/97334255; Chehimi J; Marshall JD; Salvucci O; Frank I; Chehimi S; Kawecki S; Bacheller D; Rifat S; Chouaib S; Division of Allergy, Immunology, and Infectious Diseases, Children's; Hospital of Philadelphia, PA 19104, USA.; IL-15, a new cytokine primarily produced by macrophages, has been shown to exhibit several functional properties shared with IL-2 . Treatment of PBMC from HIV-infected patients with IL-15 resulted in an increase in NK cell cytotoxicity to levels similar to those of untr
IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.: J Immunol. 1997 Jun 15;158(12):5997-6005. Unique Identifier : AIDSLINE MED/97334257; Jones LS; Rizzo LV; Agarwal RK; Tarrant TK; Chan CC; Wiggert B; Caspi RR; Laboratory of Immunology, National Eye Institute, National Institutes; of Health, Bethesda, MD 20892, USA.; Experimental autoimmune uveitis (EAU) is a T cell-mediated disease that targets the neural retina and serves as a model of human uveitis. Uveitogenic effector T cells have a Th1-like phenotype (high IFN-gamma, low IL-4), and genetic susceptibility to EAU is associated with an elevated Th1 response. Here we investigate
Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection.: J Immunol. 1997 Jun 15;158(12):6029-36. Unique Identifier : AIDSLINE MED/97334261; Wasik TJ; Jagodzinski PP; Hyjek EM; Wustner J; Trinchieri G; Lischner HW; Kozbor D; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, PA 19107, USA.; The early development of symptoms and the rapid progression of disease in some vertically infected infants are thought to reflect in part the immaturity of their immune systems. We examined the relationship between HIV-specific CTL activity and the profile of cytokine production induced by mAb to CD3 and HIV envelope
Use of ondansetron in palliative medicine.: J Pain Symptom Manage. 1997 May;13(5):302-7. Unique Identifier : AIDSLINE MED/97328946; Currow DC; Coughlan M; Fardell B; Cooney NJ; Wentworth Area Health Service, Penrith, New South Wales, Australia.; Ondansetron was the first of several selective 5-hydroxytryptamine (5-HT3) antagonists to be available as an antiemetic. Its uses in the setting of highly and moderately emetogenic chemotherapy and radiotherapy are well established. Ondansetron has also been used to manage nausea and vomiting in other patients. We rep
Presentation of a foreign peptide on the surface of tomato bushy stunt virus.: J Gen Virol. 1997 Jun;78 ( Pt 6):1213-7. Unique Identifier : AIDSLINE MED/97335244; Joelson T; Akerblom L; Oxelfelt P; Strandberg B; Tomenius K; Morris TJ; Department of Molecular Biology, Uppsala University, Sweden.; thorleif.joelson@bmc.uu.se; A 13-amino-acid peptide derived from the V3 loop of human immunodeficiency virus (HIV-1) glycoprotein 120 (gp120) was attached as a C-terminal gene fusion to the coat protein of tomato bushy stunt virus (TBSV). The architecture of this plant virus permitted external display of the foreign sequence 180 times on the sur
Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus.: J Gen Virol. 1997 Jun;78 ( Pt 6):1309-17. Unique Identifier : AIDSLINE MED/97335257; McWilliam SM; Kongsuwan K; Cowley JA; Byrne KA; Walker PJ; CSIRO Tropical Agriculture, Indooroopilly, Queensland, Australia.; A 1622 nucleotide region of the bovine ephemeral fever virus BEFV) genome, located between the second glycoprotein (GNS) gene and the polymerase (L) gene, has been cloned and sequenced in Australian (BB7721) and Chinese (Beijing-1) isolates of the virus. In the Australian isolate, the region contains five long open re
Herpesvirus saimiri-immortalized human T-cells support long-term, high titred replication of human immunodeficiency virus types 1 and 2.: J Gen Virol. 1997 Jun;78 ( Pt 6):1405-9. Unique Identifier : AIDSLINE MED/97335271; Vella C; Fickenscher H; Atkins C; Penny M; Daniels R; National Institute for Medical Research, London, UK.; Herpesvirus saimiri strain C488 transforms human CD4+ T-lymphocytes to continuous interleukin-2-dependent growth. Unlike human T-cell lines derived from tumours or those transformed by human T-lymphotropic virus 1, herpesvirus saimiri-immortalized T-cells (HVS T-cells) retain many functions of primary activated T-lymp
Synthesis and characterization in solid and solution of trans-dichloro-1-(2', 6'-difluorophenyl)-1H,3H-thiazolo [3,4-a]-benzimidazole(tri-n-propyl-phosphine)-palladium(II)": a palladium(II) complex of a ligand with anti-HIV properties.: J Inorg Biochem. 1997 Feb 1;65(2):97-102. Unique Identifier : AIDSLINE MED/97166622; Bruno G; Cusumano M; Giannetto A; Zappala M; Nicoloo F; Romeo R; Dipartimento di Chimica, Universita della Calabria, Arcavacata di; Rende, Italy.; The 1-(2 ,6 -difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole L), a highly potent nonnucleoside HIV-1 reverse transcriptase inhibitor, has been reacted with [Pd2Cl4(PPr3n)2] in order to study its coordinating properties towards metal ions. The structure of the synthesized product has been examined in solution by 1H
Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms.: J Nat Prod. 1997 May;60(5):431-8. Unique Identifier : AIDSLINE MED/97313885; McKee TC; Bokesch HR; McCormick JL; Rashid MA; Spielvogel D; Gustafson KR; Alavanja MM; Cardelline JH 2nd; Boyd MR; Laboratory of Drug Discovery Research and Development, National Cancer; Institute, Frederick, Maryland 21702-1201, USA.; New cytotoxic isomalabaricane triterpenes have been isolated from a sponge Stelletta sp. (1-7); anti-HIV pterocarpans (8 and 9) and isoflavanoids (12-16 and 18) were elucidated from two tropical plants in the genus Erythrina; and anti-HIV enniatins (20 and 22-23) were characterized from fungi in the genera Fusarium an
Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells.: J Neurol Sci. 1997 Jul;149(1):19-25. Unique Identifier : AIDSLINE MED/97311444; Benbrik E; Chariot P; Bonavaud S; Ammi-Said M; Frisdal E; Rey C; Gherardi R; Barlovatz-Meimon G; Groupe d'Etudes et de Recherches sur le Muscle et le Nerf GERMEN: ER; 269 et 315, Universite Paris XII), Faculte de Medecine, Creteil,; France.; Zidovudine ( AZT ), didanosine (ddI) and zalcitabine ( ddC ) are the reference antiretroviral therapy in patients with AIDS. A toxic mitochondrial myopathy can be observed in patients tre
Parasite antigen-induced IFN-gamma and IL-4 production by cells from pathopermissive and pathoresistant strains of mice infected with Trypanosoma cruzi.: J Parasitol. 1997 Jun;83(3):533-6. Unique Identifier : AIDSLINE MED/97338283; Humphrey JS; McCormick TS; Rowland EC; Tropical Disease Institute, College of Osteopathic Medicine, Ohio; University, Athens 45701, USA.; The cardiac pathology associated with infection by Trypanosoma cruzi in mice has been suggested to be partially dependent upon cytokine responses. The pathoresistant B10.D2 mice, which display little infection-induced myocarditis, and the pathopermissive DBA/2 mice, which show significant cardiac damage, were compared
Oral candidiasis in HIV infection: predictive value and comparison of findings in injecting drug users and homosexual men.: J Oral Pathol Med. 1997 May;26(5):237-43. Unique Identifier : AIDSLINE MED/97321455; Phelan JA; Begg MD; Lamster IB; Gorman J; Mitchell-Lewis D; Bucklan RD; el-Sadr WM; Dental Service, Department of Veterans Affairs Medical Center,; Northport, NY 11768, USA.; The objectives of this study were to compare the relationship of oral candidiasis to HIV status, cohort and CD4+ lymphocyte values in injecting drug users and homosexual men and to examine its impact on prognosis. An oral examination was added to an ongoing longitudinal study of HIV infection. Data obtained at 6-month
Autopsy findings in the tongues of 20 patients with AIDS.: J Oral Pathol Med. 1997 May;26(5):244-7. Unique Identifier : AIDSLINE MED/97321456; Leonard N; McCreary C; Flint SF; Mabruk MJ; Mulcahy F; Toner M; Department of Histopathology, Trinity College, Dublin, Ireland.; An extensive examination of the tongue was performed at autopsy in 20 consecutive patients who had died with AIDS. Abnormalities in the tongue were detected in 18 (90%) of the cases; the commonest lesions were ulceration (11), candidosis (8) and small foci of hyperkeratosis (10). The most extensive lesions were caused
The structure of an RNA "kissing" hairpin complex of the HIV TAR hairpin loop and its complement.: J Mol Biol. 1997 May 30;269(1):52-66. Unique Identifier : AIDSLINE MED/97336205; Chang KY; Tinoco I Jr; Department of Chemistry, University of California at Berkeley,; 94720-1460, USA.; We have used nuclear magnetic resonance (NMR) to obtain the structure of an RNA kissing hairpin complex formed between the HIV-2 TAR hairpin loop and a hairpin with a complementary loop sequence. Kissing hairpins are important in natural antisense reactions; their complex is a specific target for protein binding. Th
Postburn constitutional changes in T-cell reactivity occur in CD8+ rather than in CD4+ cells.: J Trauma. 1997 May;42(5):872-80; discussion 880-1. Unique Identifier : AIDSLINE MED/97335003; Zedler S; Faist E; Ostermeier B; von Donnersmarck GH; Schildberg FW; Department of Surgery, Ludwig-Maximilians-University Munich, Klinikum; Grosshadern, Germany.; BACKGROUND: Impairment of T-helper cell function and polarization toward T-helper 2-type cytokine synthesis have been postulated to represent a major cause for posttraumatic immunodeficiency. With a recently developed technology for intracellular cytokine measurement, a new diagnostic tool has become available to disc
In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression.: J Virol. 1997 Jul;71(7):4871-81. Unique Identifier : AIDSLINE MED/97332315; Shioda T; Oka S; Xin X; Liu H; Harukuni R; Kurotani A; Fukushima M; Hasan MK; Shiino T; Takebe Y; Iwamoto A; Nagai Y; Department of Viral Infection, University of Tokyo, and AIDS Research; Center, Minato-ku, Japan.; According to the rate of depletion of CD4 cell counts, we grouped 12 cases of human immunodeficiency virus type 1 (HIV-1) infection as 6 rapid (21.0 to 33.8 cells per microl per month) and 6 slow 0.9 to 7.9 cells per microl per month) progressors and determined the individual viral quasispecies patterns by sequencing
Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation.: J Virol. 1997 Jul;71(7):4892-903. Unique Identifier : AIDSLINE MED/97332317; Schneider R; Campbell M; Nasioulas G; Felber BK; Pavlakis GN; Human Retrovirus Section, National Cancer Institute-Frederick Cancer; Research and Development Center, ABL-Basic Research Program, Maryland; 21702-1201, USA.; The expression of gag, pol, and env of human immunodeficiency virus type 1 (HIV-1) depends on the presence of the viral Rev protein. This dependence is, at least in part, due to the presence of negatively acting sequences (inhibitory or instability elements [INS]) located within unspliced and partially spliced mRNAs.
Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission.: J Virol. 1997 Jul;71(7):4981-4. Unique Identifier : AIDSLINE MED/97332327; Putkonen P; Makitalo B; Bottiger D; Biberfeld G; Thorstensson R; Swedish Institute for Infectious Disease Control, Karolinska; Institute, Stockholm, Sweden. per.putkonen@smi.ki.se; At present it is not known which form of immunity would be most effective against infection with human immunodeficiency virus HIV). To evaluate the possible role of cellular immunity, we examined whether four HIV type 2-exposed but seronegative macaques developed cellular immune responses and determined whether these
Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion.: J Virol. 1997 Jul;71(7):5003-11. Unique Identifier : AIDSLINE MED/97332331; Picard L; Simmons G; Power CA; Meyer A; Weiss RA; Clapham PR; Chester Beatty Laboratories, Institute of Cancer Research, London,; United Kingdom. laurent@icr.ac.uk; Human immunodeficiency virus type 1 (HIV-1) entry is governed by the interaction of the viral envelope glycoprotein (Env) with its receptor. The HIV-1 receptor is composed of two molecules, the CD4 binding receptor and a coreceptor. The seven-membrane-spanning chemokine receptor CCR-5 is one of the coreceptors used by
Specific targeting to CD4+ cells of recombinant vesicular stomatitis viruses encoding human immunodeficiency virus envelope proteins.: J Virol. 1997 Jul;71(7):5060-8. Unique Identifier : AIDSLINE MED/97332337; Johnson JE; Schnell MJ; Buonocore L; Rose JK; Department of Genetics, Yale University School of Medicine, New Haven,; Connecticut 06510, USA.; We generated replication-competent, recombinant vesicular stomatitis viruses (VSVs) expressing the human immunodeficiency virus (HIV) envelope protein or an HIV-VSV chimeric envelope protein in which the cytoplasmic domain of the HIV envelope protein was replaced with that from the VSV glycoprotein (G). These recombin
Evolution of envelope-specific antibody responses in monkeys experimentally infected or immunized with simian immunodeficiency virus and its association with the development of protective immunity.: J Virol. 1997 Jul;71(7):5069-79. Unique Identifier : AIDSLINE MED/97332338; Cole KS; Rowles JL; Jagerski BA; Murphey-Corb M; Unangst T; Clements JE; Robinson J; Wyand MS; Desrosiers RC; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; Previous studies of attenuated simian immunodeficiency virus SIV) vaccines in rhesus macaques have demonstrated the development of broad protection against experimental challenge, indicating the potential for the production of highly effective immune responses to SIV antigens. However, the development of this protecti
Biological characterization of human immunodeficiency virus type 1 clones derived from different organs of an AIDS patient by long-range PCR.: J Virol. 1997 Jul;71(7):5140-7. Unique Identifier : AIDSLINE MED/97332347; Dittmar MT; Simmons G; Donaldson Y; Simmonds P; Clapham PR; Schulz TF; Weiss RA; Virology Laboratory, Chester Beatty Laboratories, Institute of Cancer; Research, London, United Kingdom. matthias@icr.ac.uk; In order to characterize the biological properties of human immunodeficiency virus type 1 (HIV-1) variants from different tissues (peripheral blood mononuclear cells [PBMC], lymph node, spleen, brain, and lung) of one patient, we have chosen long-range PCR to amplify virtually full-length HIV proviruses and to constru
Specific cytotoxic T lymphocytes are involved in in vivo clearance of infectious bronchitis virus.: J Virol. 1997 Jul;71(7):5173-7. Unique Identifier : AIDSLINE MED/97332350; Seo SH; Collisson EW; Department of Veterinary Pathobiology, Texas A&M University, College; Station 77843-4467, USA.; Cytotoxic T-lymphocyte (CTL) responses to infectious bronchitis virus (IBV) were determined at regular intervals between 3 and 30 days postinfection (p.i.). The maximum response with 82% lysis of labeled target cells was detected at 10 days p.i. The specific CTL response did not begin to decline until the amount of vi
Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA.: J Virol. 1997 Jul;71(7):5178-88. Unique Identifier : AIDSLINE MED/97332351; Guo J; Henderson LE; Bess J; Kane B; Levin JG; Laboratory of Molecular Genetics, National Institute of Child Health; and Human Development, Bethesda, Maryland 20892, USA.; During the first strand transfer in reverse transcription, minus-strand strong-stop DNA [(-) SSDNA] is annealed to the 3 end of the acceptor RNA in a reaction mediated by base-pairing between terminal repeat sequences in the RNA and their complement in the DNA. The large stem-loop structure in the repeat region known
The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells.: J Virol. 1997 Jul;71(7):5259-67. Unique Identifier : AIDSLINE MED/97332360; Simon JH; Fouchier RA; Southerling TE; Guerra CB; Grant CK; Malim MH; Howard Hughes Medical Institute, University of Pennsylvania School of; Medicine, Philadelphia 19104-6148, USA.; The Vif protein of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses is required for efficient replication in primary cells and certain immortalized cell lines in vitro and, in all likelihood, for the establishment of pathogenic infections in vivo. Current hypotheses concerning Vif s mechanism of acti
Neurologic disease induced by polytropic murine retroviruses: neurovirulence determined by efficiency of spread to microglial cells.: J Virol. 1997 Jul;71(7):5287-94. Unique Identifier : AIDSLINE MED/97332363; Robertson SJ; Hasenkrug KJ; Chesebro B; Portis JL; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Hamilton, Montana 59840, USA.; Several murine leukemia viruses (MuLV) induce neurologic disease in susceptible mice. To identify features of central nervous system (CNS) infection that correlate with neurovirulence, we compared two neurovirulent MuLV, Fr98 and Fr98/SE, with a nonneurovirulent MuLV, Fr54. All three viruses utilize the polytropic rec
Characterization of glycosylated Gag expressed by a neurovirulent murine leukemia virus: identification of differences in processing in vitro and in vivo.: J Virol. 1997 Jul;71(7):5355-60. Unique Identifier : AIDSLINE MED/97332371; Fujisawa R; McAtee FJ; Zirbel JH; Portis JL; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories,; National Institute of Allergy and Infectious Diseases, Hamilton,; Montana 59840, USA.; The neuroinvasiveness of a chimeric murine retrovirus, CasFrKP KP), is dependent on the expression of glycosylated Gag gp85gag). This viral protein is the product of alternate translation initiation 88 codons upstream of and in frame with the initiation codon of pr65gag, the precursor of the viral core proteins. Altho
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition.: J Virol. 1997 Jul;71(7):5382-90. Unique Identifier : AIDSLINE MED/97332375; Miller MD; Farnet CM; Bushman FD; Infectious Disease Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; We have investigated the organization and function of human immunodeficiency virus type 1 (HIV-1) preintegration complexes PICs), the large nucleoprotein particles that carry out cDNA integration in vivo. PICs can be isolated from HIV-1-infected cells, and such particles are capable of carrying out integration reactio
Sequence and drug susceptibility of subtype C reverse transcriptase from human immunodeficiency virus type 1 seroconverters in Zimbabwe.: J Virol. 1997 Jul;71(7):5441-8. Unique Identifier : AIDSLINE MED/97332382; Shafer RW; Eisen JA; Merigan TC; Katzenstein DA; Department of Medicine, Stanford University, California 94305, USA.; rshafer@cmgm.stanford.edu; Naturally occurring human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) variability has implications for the success of antiretroviral therapy. We determined the sequence of the polymerase-coding region of RT from virus isolates from 12 Zimbabwean individuals recently infected with HIV-1. The 12 RT
Complete nucleotide sequence of the new simian T-lymphotropic virus, STLV-PH969 from a Hamadryas baboon, and unusual features of its long terminal repeat.: J Virol. 1997 Jul;71(7):5464-72. Unique Identifier : AIDSLINE MED/97332385; Van Brussel M; Goubau P; Rousseau R; Desmyter J; Vandamme AM; Rega Institute for Medical Research and University Hospitals, Leuven,; Belgium. vanbruss@uz.kuleuven.ac.be; A third type of primate T-lymphotropic virus, PTLV-L, with STLV-PH969 as a prototype, has recently been isolated from an African baboon (Papio hamadryas). Classification of this virus has been based on partial sequence analysis of cDNA from a virus-producing cell line, PH969. We obtained the complete nucleotide sequen
Immunogenicity of a contiguous T-B synthetic epitope of the A/PR/8/34 influenza virus.: J Virol. 1997 Jul;71(7):5473-80. Unique Identifier : AIDSLINE MED/97332386; Brumeanu TD; Casares S; Bot A; Bot S; Bona CA; Department of Microbiology, Mount Sinai School of Medicine, New York,; New York 10029, USA.; A contiguously linked T-B synthetic viral epitope 110HA120-150HA159,T-B) was investigated for its potency in inducing humoral and cellular immune responses in vivo. The T-cell epitope 110HA120 corresponds to the site 1 hemagglutinin HA) of the A/PR/8/34 (PR8) influenza virus and is recognized by CD4 T cells in associa
The kappaB sites in the human immunodeficiency virus type 1 long terminal repeat enhance virus replication yet are not absolutely required for viral growth.: J Virol. 1997 Jul;71(7):5495-504. Unique Identifier : AIDSLINE MED/97332389; Chen BK; Feinberg MB; Baltimore D; Department of Biology, Massachusetts Institute of Technology,; Cambridge 02139, USA.; The dependence of human immunodeficiency virus type 1 (HIV-1) on its NF-kappaB binding sites (kappaB sites) for replication in transformed and primary T-cell targets was examined by infecting cells with HIV-1 reporter viruses containing kappaB site enhancer mutations. Viral transcription was measured either with lucif
Molecular analysis of the feline immunodeficiency virus protease: generation of a novel form of the protease by autoproteolysis and construction of cleavage-resistant proteases.: J Virol. 1997 Jul;71(7):5505-11. Unique Identifier : AIDSLINE MED/97332390; Laco GS; Fitzgerald MC; Morris GM; Olson AJ; Kent SB; Elder JH; Department of Molecular Biology, The Scripps Research Institute, La; Jolla, California 92037, USA.; The feline immunodeficiency virus (FIV) protease is essential for virion maturation and subsequent viral replication in that it cleaves the Gag and Gag/Pol polyproteins at eight sites to release the respective structural proteins and enzymes. During purification of a recombinant FIV protease (PR), we noted that it und
Inhibition of human immunodeficiency virus replication by the herpes simplex virus virion host shutoff protein.: J Virol. 1997 Jul;71(7):5521-7. Unique Identifier : AIDSLINE MED/97332392; Hamouda T; McPhee R; Hsia SC; Read GS; Holland TC; King SR; Department of Immunology and Microbiology, Wayne State University; School of Medicine, Detroit, Michigan 48201, USA.; The herpes simplex virus (HSV) virion host shutoff gene (vhs) encodes a protein which nonspecifically accelerates the degradation of mRNA molecules, leading to inhibition of protein synthesis. This ability to inhibit a critical cellular function suggested that vhs could be used as a suicide gene in certain gene therap
Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type 1 regulatory genes.: J Virol. 1997 Jul;71(7):5528-39. Unique Identifier : AIDSLINE MED/97332393; Hinkula J; Svanholm C; Schwartz S; Lundholm P; Brytting M; Engstrom G; Benthin R; Glaser H; Sutter G; Kohleisen B; Erfle V; Okuda K; Wigzell H; Wahren B; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden. Jorma.Hinkula@smi.ki.se; Mice immunized with the regulatory genes nef, rev, and tat from human immunodeficiency virus type 1 developed both humoral and cellular immune responses to the gene products Nef, Rev, and Tat. This study demonstrates that it is feasible to induce immune reactions to all of these regulatory gene products. Humoral respo
Regression of papillomas induced by cottontail rabbit papillomavirus is associated with infiltration of CD8+ cells and persistence of viral DNA after regression.: J Virol. 1997 Jul;71(7):5540-8. Unique Identifier : AIDSLINE MED/97332394; Selvakumar R; Schmitt A; Iftner T; Ahmed R; Wettstein FO; Department of Microbiology and Immunology, School of Medicine,; University of California, Los Angeles 90095-1747, USA.; Cottontail rabbit papillomavirus (CRPV) is a highly oncogenic papillomavirus and has been successfully used as a model to develop protective vaccines against papillomaviruses. Papillomas induced by the virus may spontaneously regress, suggesting that CRPV can also serve as a model to develop therapeutic vaccines. As a
Mutagenesis analysis of the murine leukemia virus matrix protein: identification of regions important for membrane localization and intracellular transport.: J Virol. 1997 Jul;71(7):5549-59. Unique Identifier : AIDSLINE MED/97332395; Soneoka Y; Kingsman SM; Kingsman AJ; Department of Biochemistry, University of Oxford, United Kingdom.; We have created two sets of substitution mutations in the Moloney murine leukemia virus (Mo-MuLV) matrix protein in order to identify domains involved in association with the plasma membrane and in incorporation of the viral envelope glycoproteins into virus particles. The first set of mutations was targeted at putati
Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.: J Virol. 1997 Jul;71(7):5579-92. Unique Identifier : AIDSLINE MED/97332398; Stewart SA; Poon B; Jowett JB; Chen IS; Department of Microbiology and Immunology, UCLA School of Medicine and; Jonsson Comprehensive Cancer Center, Los Angeles, California 90095,; USA.; The human immunodeficiency virus type 1 (HIV-1) vpr gene encodes a protein which induces arrest of cells in the G2 phase of the cell cycle. Here, we demonstrate that following the arrest of cells in G2, Vpr induces apoptosis in human fibroblasts, T cells, and primary peripheral blood lymphocytes. Analysis of various m
Vpr of simian immunodeficiency virus of African green monkeys is required for replication in macaque macrophages and lymphocytes.: J Virol. 1997 Jul;71(7):5593-602. Unique Identifier : AIDSLINE MED/97332399; Campbell BJ; Hirsch VM; Laboratory of Infectious Diseases, National Institute of Allergy and; Infectious Diseases, NIH Twinbrook II Facility, Rockville, Maryland; 20852, USA.; The genomes of simian immunodeficiency viruses isolated from African green monkeys (SIVagm) contain a single accessory gene homolog of human immunodeficiency virus type 1 (HIV-1) vpr. This genomic organization differs from that of SIVsm-SIVmac-HIV-2 group viruses, which contain two gene homologs, designated vpr and vp
Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection.: J Virol. 1997 Jul;71(7):5608-13. Unique Identifier : AIDSLINE MED/97332401; Zhang L; Huang Y; Yuan H; Chen BK; Ip J; Ho DD; The Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; Human immunodeficiency virus type 1 (HIV-1)-infected individuals who remain asymptomatic despite prolonged infection present a unique opportunity to understand virologic and immunologic factors involved in the pathogenesis of AIDS. We have previously identified a group of long-term survivors (LTS) who are clinically h
Genetic analysis of interactions between Gag proteins of Rous sarcoma virus.: J Virol. 1997 Jul;71(7):5624-30. Unique Identifier : AIDSLINE MED/97332404; Li X; Yuan B; Goff SP; Howard Hughes Medical Institute and Department of Biochemistry and; Molecular Biophysics, Columbia University College of Physicians and; Surgeons, New York, New York 10032, USA.; The yeast two-hybrid system was used to characterize homomeric interactions between the Gag proteins of Rous sarcoma virus RSV). The RSV Gag precursor was found to interact strongly with itself and not with various control proteins. The RSV Gag did not interact significantly with Gag proteins of a variety of other ret
Subunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity.: J Virol. 1997 Jul;71(7):5668-72. Unique Identifier : AIDSLINE MED/97332412; Loya S; Gao HQ; Avidan O; Boyer PL; Hughes SH; Hizi A; Department of Cell Biology and Histology, Sackler School of Medicine,; Tel Aviv University, Israel.; Treatment of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) with N-ethylmaleimide (NEM) selectively inhibits the RNase H activity. The cysteine residue at position 280 (C280) is the target for NEM; HIV-1 RT carrying the mutation C280S is resistant to NEM. Since HIV-1 RT is composed of two related
A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB).: J Virol. 1997 Jul;71(7):5678-83. Unique Identifier : AIDSLINE MED/97332414; Strizki JM; Turner JD; Collman RG; Hoxie J; Gonzalez-Scarano F; Department of Neurology and Microbiology, University of Pennsylvania; Medical Center, Philadelphia 19104-6146, USA.; We used a monoclonal antibody (12G5) directed against an extracellular domain of CXCR-4 to investigate the role of this receptor in infection of immortalized lymphoid cell lines, peripheral blood mononuclear cells (PBMCs), and primary brain microglia with a dual-tropic strain of human immunodeficiency virus (HIV-1(89.
Two distinct oncornaviruses harbor an intracytoplasmic tyrosine-based basolateral targeting signal in their viral envelope glycoprotein.: J Virol. 1997 Jul;71(7):5696-702. Unique Identifier : AIDSLINE MED/97332418; Lodge R; Delamarre L; Lalonde JP; Alvarado J; Sanders DA; Dokhelar MC; Cohen EA; Lemay G; Departement de Microbiologie et Immunologie, Universite de; Montreal,Quebec, Canada.; It has been clearly established that the budding of the human immunodeficiency virus (HIV-1), a lentivirus, occurs specifically through the basolateral membrane in polarized epithelial cells. More recently, the signal was assigned to a tyrosine-based motif located in the intracytoplasmic domain of the envelope glycopr
Human immunodeficiency virus type 1 and 2 envelope glycoproteins oligomerize through conserved sequences.: J Virol. 1997 Jul;71(7):5706-11. Unique Identifier : AIDSLINE MED/97332420; Center RJ; Kemp BE; Poumbourios P; St. Vincent's Institute of Medical Research, Fitzroy, Victoria,; Australia.; Hetero-oligomerization between human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (Env) truncation mutants and epitope-tagged gp160 is dependent on the presence of gp41 transmembrane protein (TM) amino acids 552 to 589, a putative amphipathic alpha-helical sequence. HIV-2 Env truncation mutants containi
Elevated cerebrospinal fluid glutamate in patients with HIV-related dementia [letter; comment]: JAMA. 1997 Jun 25;277(24):1931. Unique Identifier : AIDSLINE MED/97344100; Gurwitz D; Kloog Y
Social ties and susceptibility to the common cold.: JAMA. 1997 Jun 25;277(24):1940-4. Unique Identifier : AIDSLINE MED/97344107; Cohen S; Doyle WJ; Skoner DP; Rabin BS; Gwaltney JM Jr; Department of Psychology, Carnegie Mellon University, Pittsburgh, PA; 15213, USA. SCOHEN@CMU.EDU; OBJECTIVE: To examine the hypothesis that diverse ties to friends, family, work, and community are associated with increased host resistance to infection. DESIGN: After reporting the extent of participation in 12 types of social ties (eg, spouse, parent, friend, workmate, member of social group), subjects were given n
Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the International AIDS Society-USA panel.: JAMA. 1997 Jun 25;277(24):1962-9. Unique Identifier : AIDSLINE MED/97344111; Carpenter CC; Fischl MA; Hammer SM; Hirsch MS; Jacobsen DM; Katzenstein DA; Montaner JS; Richman DD; Saag MS; Schooley RT; Thompson MA; Vella S; Yeni PG; Volberding PA; Brown University School of Medicine, Providence, RI 02906, USA.; OBJECTIVE: To provide current recommendations for antiretroviral therapy for human immunodeficiency virus (HIV) disease. PARTICIPANTS: The original International AIDS Society-USA 13-member panel representing international expertise in antiretroviral research and care of patients with HIV infection. EVIDENCE: The follo
Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes.: Kidney Int. 1997 May;51(5):1520-8. Unique Identifier : AIDSLINE MED/97294795; Nassar GM; Montero A; Fukunaga M; Badr KF; Renal Divisions of Emory University, Atlanta, Georgia, USA.; Human peripheral blood monocytes (HPBMs) express 5-lipoxygenase 5-LO) and 5-LO activating protein (FLAP), and hence have an ability to synthesize proinflammatory leukotrienes (LTs). Regulation of 5-LO and FLAP expression is a major determinant of cellular LT synthesis. We examined the effects of proinflammatory [inter
Renal TGF-beta in HIV-associated kidney diseases.: Kidney Int. 1997 May;51(5):1568-77. Unique Identifier : AIDSLINE MED/97294801; Bodi I; Kimmel PL; Abraham AA; Svetkey LP; Klotman PE; Kopp JB; Department of Medicine, George Washington University Medical Center,; Washington, D.C. USA.; Human immunodeficiency virus (HIV)-1 infection may be complicated by progressive renal glomerular disease, including focal segmental glomerulosclerosis (FSGS) and proliferative glomerulonephritis. We examined renal tissue from 71 patients, including biopsies and autopsies from patients in the presence and absence of H
AIDS among children--United States, 1996. Division of HIV/AIDS Prevention, CDC [corrected and republished in J Sch Health 1997 May;67(5):175-7]: J Sch Health. 1997 Apr;67(4):141-3. Unique Identifier : AIDSLINE MED/97276439
Differences in sexual risk-taking behavior with state of inebriation in an aboriginal population in Ontario, Canada.: J Stud Alcohol. 1997 May;58(3):312-22. Unique Identifier : AIDSLINE MED/97276471; Myers T; Bullock SL; Calzavara LM; Cockerill R; Marshall VW; Faculty of medicine, University of Toronto, Ontario, Canada.; OBJECTIVE: This article describes the self-reported use of substances, participation in unprotected intercourse and differences in sexual risk-taking behavior with state of inebriation among a group of aboriginal (First Nations) people in Ontario. And, in so doing, attempts to answer some of the questions about the as
Interests and policies of the state of Sarawak, Malaysia regarding intellectual property rights for plant derived drugs.: J Ethnopharmacol. 1996 Apr;51(1-3):201-4. Unique Identifier : AIDSLINE MED/96214150; Chung FJ; Sarawak, on the island of Borneo, is known internationally for its rich rain forests, flora and fauna. Its rain forests, occupying two-thirds of its geographical area shelters 2500 tree species, 5500 flowering plants and over 20 000 different kinds of animals and insects. Such abundance of plants, and in particular, i
[Mortality caused by human immunodeficiency virus in the Autonomous Communities in 1992 (letter)]: Med Clin (Barc). 1997 Mar 22;108(11):436-7. Unique Identifier : AIDSLINE MED/97273398; Martinez de Aragon MV; Castilla J; Gutierrez A; Llacer A
[Patterns of resistance to antitubercular agents in Girona. Diagnostic and therapeutic implications (letter; comment)]: Med Clin (Barc). 1997 Mar 22;108(11):438-9. Unique Identifier : AIDSLINE MED/97273400; Camafort Babkowski M; Algarra Vento J; de Batlle Surroca J; Garcia-Bragado Dalmau F
[Gonorrhea is increasing among homosexual men. Is the risk of STD and AIDS forgotten?]: Lakartidningen. 1997 Jun 11;94(24):2261-2, 2265. Unique Identifier : AIDSLINE MED/97347679; Grutzmeier S; kvallsmottagningen, Venhalsan, Sodersjukhuset, Stockholm.
Pancreatorenal syndrome associated with combination antiretroviral therapy in HIV infection [letter]: Lancet. 1997 Jun 14;349(9067):1745-6. Unique Identifier : AIDSLINE MED/97336644; Stricker RB; Man KM; Bouvier DB; Goldberg DA; Mendiola AE
Abscess formation in Listeria monocytogenes-infected gamma delta T cell deficient mouse mutants involves alpha beta T cells.: Microb Pathog. 1997 Feb;22(2):123-8. Unique Identifier : AIDSLINE MED/97202482; Thoma-Uszynski S; Ladel CH; Kaufmann SH; Department of Immunology, University of Ulm, Germany.; Although mutant mice lacking gamma delta T cells resolve Listeria monocytogenes infection, extensive abscesses are formed. Manifestation of these inflammatory lesions is prevented by in vivo depletion with monoclonal antibodies of CD4, CD8 or both T cell subsets. We conclude that these inflammatory tissue reactions de
Suppressed induction of 2-5AS in cells with HTLV-I is not associated with the fluctuation of IFN-receptor, IFN-regulatory factors (IRF-1 and IRF-2) or STAT-1 alpha.: Microbiol Immunol. 1997;41(1):63-6. Unique Identifier : AIDSLINE MED/97242989; Yokosawa N; Indoh T; Kubota T; Yashiki T; Fujii N; Department of Microbiology, Sapporo University School of Medicine,; Hokkaido, Japan.; Some viruses seem to be capable of suppressing interferon IFN)-induced 2 ,5 -oligoadenylate synthetase (2-5AS) induction. Cells infected with human T-lymphotropic virus type-I (HTLV-I) show different natures for the constitutive production of IFN-gamma or sensitivity to IFN. Poor induction of 2-5AS was found in IFN-ga
natural antimutagenic agents may prolong efficacy of human immunodeficiency virus drug therapy.: Med Hypotheses. 1997 Mar;48(3):215-20. Unique Identifier : AIDSLINE MED/97285667; McCarty MF; Nutrition 21, San Diego, CA 92109, USA.; The long-term efficacy of new combination drug therapies for human immunodeficiency virus infection may be limited by the tendency of transfected human immunodeficiency virus to mutate to drug-resistant forms. This argues for the use of safe antimutagenic measures as adjuvants to such therapies. Certain nutrients and
Superantigens as virulence factors in autoimmunity and immunodeficiency diseases.: Med Hypotheses. 1997 Mar;48(3):253-9. Unique Identifier : AIDSLINE MED/97285673; Soos JM; Schiffenbauer J; Torres BA; Johnson HM; Department of Microbiology and Cell Science, University of Florida,; Gainesville 32611, USA.; Virulence factors are microbial products that are known to be harmful to the host and may assist in the pathogenesis of the micro-organism. Superantigens, including those produced by bacteria and viruses, clearly act as virulence factors. The clinical effects of superantigens can be not only acute but also chronic and
Do holes in the T-cell repertoire have a center-surround regulatory structure? A rationale for the bifurcation of the Th1 and Th2 pathways of differentiation.: Med Hypotheses. 1997 Mar;48(3):261-5. Unique Identifier : AIDSLINE MED/97285674; Mannie MD; Department of Microbiology and Immunology, East Carolina University; School of Medicine, Greenville, NC 27858-4354, USA.; Regulatory strategies controlling the balance of Th1 versus Th2 T-helper cell responses have been a long-standing mystery with important consequences for immunological disease. A novel model is presented to explain the comparative differentiation of Th1 and Th2 T cells as part of a mechanism to ensure self-tolerance.
[Effect of amino acid substitutions in the gp120 V3-loop sequence on serological cross-reactivity between various HIV-1 subtypes]: Mol Biol (Mosk). 1997 Mar-Apr;31(2):338-43. Unique Identifier : AIDSLINE MED/97316189; Iaroslavtseva NG; Shchelkanov MIu; Iudin AN; Navruzbekov GA; Semiletov IuA; Karamov EV
[Photoaffinity modification of human immunodeficiency virus reverse transcriptase with an analog of deoxyuridine-5'-triphosphate, containing an arylazide group]: Mol Biol (Mosk). 1997 Mar-Apr;31(2):344-52. Unique Identifier : AIDSLINE MED/97316190; Shcherbik NV; Khodyreva SN; Vlasov VA; Dobrikov MI; Dymshits GM; Lavrik OI
[Inhibition of the polymerization reaction, catalyzed by human immunodeficiency virus reverse transcriptase using model substrates by derivatives of oligo-1,3-thiazolecarboxamides]: Mol Biol (Mosk). 1997 Mar-Apr;31(2):359-65. Unique Identifier : AIDSLINE MED/97316192; Timofeeva OA; Riabinin VA; Siniakov AN; Zakharova OD; Iamkovoi VI; Tarrago-Litvak L; Litvak S; Nevinskii GA
[Interaction of human immunodeficiency virus reverse transcriptase with oligonucleotide derivatives containing polycyclic aromatic groups at the 5'-terminus]: Mol Biol (Mosk). 1997 Mar-Apr;31(2):373-9. Unique Identifier : AIDSLINE MED/97316194; Zakharova OD; Mart'ianov IV; Timofeeva OA; Sottofattori E; Pyshnyi DV; Balbi A; Litvak S; Tarrago-Litvak L; Nevinskii GA
Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine.: Mutat Res. 1997 May 23;390(3):223-31. Unique Identifier : AIDSLINE MED/97330112; Agarwal RP; Olivero OA; Medical Oncology, University of Miami School of Medicine, FL 33136,; USA.; AZT (3 -azido-2 ,3 -dideoxythymidine), the first nucleoside analog approved for the treatment of AIDS (acquired immunodeficiency syndrome), induces significant toxic effects in humans exposed to therapeutic doses. As an inhibitor of the HIV-1 human im
Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group.: N Engl J Med. 1997 Jul 3;337(1):15-21. Unique Identifier : AIDSLINE MED/97330766; van der Horst CM; Saag MS; Cloud GA; Hamill RJ; Graybill JR; Sobel JD; Johnson PC; Tuazon CU; Kerkering T; Moskovitz BL; Powderly WG; Dismukes WE; Division of Infectious Diseases, Department of Medicine, University of; North Carolina at Chapel Hill, 27599-7030, USA.; BACKGROUND: Treatment with low-dose amphotericin B (0.4 mg per kilogram of body weight per day) or oral azole therapy in patients with the acquired immunodeficiency syndrome (AIDS) and cryptococcal meningitis has been associated with high mortality and low rates of cerebrospinal fluid sterilization. METHODS: In a doub
Residual clones in childhood leukemia [letter; comment]: N Engl J Med. 1997 Jul 3;337(1):50-1. Unique Identifier : AIDSLINE MED/97330777; Rabkin CS; Muller J; Goedert JJ
Physician-assisted suicide and patients with HIV disease [letter; comment]: N Engl J Med. 1997 Jul 3;337(1):56. Unique Identifier : AIDSLINE MED/97330786; McKeogh M
Th1 epitope repertoire on the alpha subunit of human muscle acetylcholine receptor in myasthenia gravis.: Neurology. 1997 Jun;48(6):1643-53. Unique Identifier : AIDSLINE MED/97335115; Wang ZY; Okita DK; Howard J Jr; Conti-Fine BM; Department of Biochemistry, College of Biological Sciences, University; of Minnesota, St. Paul 55108, USA.; In myasthenia gravis (MG), CD4+ T helper cells recognize the muscle acetylcholine receptor (AChR) alpha subunit. We investigated the epitope repertoire of anti-AChR blood CD4+ Th1 cells from 13 myasthenic patients and three healthy controls, using overlapping synthetic peptides screening the alpha subunit sequence and
Acute cortical necrosis in acquired immunodeficiency syndrome AIDS).: Nephrol Dial Transplant. 1997 Mar;12(3):585-7. Unique Identifier : AIDSLINE MED/97229151; Hertig A; Couprie R; Haymann JP; Mougenot B; Farres N; Peraldi MN; Rondeau E; Sraer JD; Service de Nephrologie A, Hopital Tenon, Paris, France.
Renal failure with large echogenic kidneys.: Nephrol Dial Transplant. 1997 Mar;12(3):610-1. Unique Identifier : AIDSLINE MED/97229160; Pouria S; Neild GH; Renal Unit, Middlesex Hospital, London, UK.
Assessing and enhancing compliance with antiretroviral therapy [news]: Nurse Pract. 1997 Apr;22(4):211-2, 215, 219. Unique Identifier : AIDSLINE MED/97274922; Klaus BD; Grodesky MJ
Prolonged Th1-like response generated by a Plasmodium yoelii-specific T cell clone allows complete clearance of infection in reconstituted mice.: Parasite Immunol. 1997 Mar;19(3):111-26. Unique Identifier : AIDSLINE MED/97260698; Amante FH; Good MF; Cooperative Research Centre for Vaccine Technology, Queensland; Institute of Medical Research, PO Royal Brisbane Hospital, Australia.; In the present study, we report the ability of in vitro cultured CD4+ T cells, generated following immunization with dead blood stage P. yoelii parasites, to mediate protection against homologous challenge infection in reconstituted nude mice. P. yoelii-specific T cell line cells produced IFN-gamma after in vitro stim
Intranasal administration of Schistosoma mansoni adult worm antigen in combination with cholera toxin induces a Th2 cell response.: Parasite Immunol. 1997 Apr;19(4):183-90. Unique Identifier : AIDSLINE MED/97293312; Akhiani AA; Nilsson LA; Ouchterlony O; Department of Medical Microbiology and Immunology, University of; Goteborg, Sweden.; Mice immunized with soluble adult worm antigen (SWAP) in combination with cholera toxin (CT) displayed significantly larger numbers of IgG1, IgM and IgA secreting cells in the spleen and in the lungs as compared to mice which had received SWAP only. The ratio of SWAP-specific IgG1 to IgG2a antibody-secreting spleen ce
Cytomegalovirus infection in children with human immunodeficiency virus infection.: Pediatr Infect Dis J. 1997 Apr;16(4):358-63. Unique Identifier : AIDSLINE MED/97262928; Kitchen BJ; Engler HD; Gill VJ; Marshall D; Steinberg SM; Pizzo PA; Mueller BU; Pediatric Branch, National Cancer Institute, National Institutes of; Health, Bethesda, MD, USA. kitchenb@pbmac.nci.nih.gov; OBJECTIVES: To determine retrospectively the prevalence of positive cytomegalovirus ( CMV ) cultures in pediatric patients with human immunodeficiency virus infection. METHODS: We reviewed the records of 273 children with human
Adenovirus viremia in human immunodeficiency virus-infected children.: Pediatr Infect Dis J. 1997 Apr;16(4):413-5. Unique Identifier : AIDSLINE MED/97262939; Ferdman RM; Ross L; Inderlied C; Church JA; Division of Clinical Immunology and Allergy, University of Southern; California School of Medicine, Los Angeles, USA.; rferdman%smtpgate@chlais.usc.edu
Asymptomatic intestinal microsporidiosis in a human immunodeficiency virus-seronegative, immunocompetent Zambian child.: Pediatr Infect Dis J. 1997 Apr;16(4):415-6. Unique Identifier : AIDSLINE MED/97262940; Hautvast JL; Tolboom JJ; Derks TJ; Beckers P; Sauerwein RW; Department of Paediatrics, University Hospital Nijmegen St. Radboud,; The Netherlands.
Disseminated histoplasmosis in a human immunodeficiency virus-infected African child.: Pediatr Infect Dis J. 1997 Apr;16(4):417-8. Unique Identifier : AIDSLINE MED/97262942; Pillay T; Pillay DG; Bramdev A; Department of Paediatrics and Child Health, Faculty of Medicine; University of Natal Kwazulu/Natal, South Africa.; pillayti@med.und.ac.za
Future indications for macrolides.: Pediatr Infect Dis J. 1997 Apr;16(4):457-62. Unique Identifier : AIDSLINE MED/97262951; Tarlow MJ; Block SL; Harris J; Kolokathis A; Department of Pediatrics, Birmingham Heartlands Hospital, Bordesley; Green East, UK.; The antimicrobial spectrum of azithromycin and clarithromycin suggests a number of further uses for these newer macrolides. Favorable clinical and bacteriologic responses have been reported with both antibiotics in children with community-acquired pneumonia. Response rates were high for overall patient populations and
Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA.: Nucleic Acids Res. 1997 Jun 1;25(11):2167-73. Unique Identifier : AIDSLINE MED/97298169; Koppelhus U; Zachar V; Nielsen PE; Liu X; Eugen-Olsen J; Ebbesen P; Department of Virus and Cancer, Danish Cancer Society, Gustav Wieds; Vej 10, DK-8000 Aarhus C, Denmark. ukop@biobase.dk; We have tested the inhibitory potential of peptide nucleic acid PNA) on in vitro reverse transcription of the HIV-1 gag gene. PNA was designed to target different regions of the HIV-1 gag gene and the effect on reverse transcription by HIV-1, MMLV and AMV reverse transcriptases (RTs) was investigated. We found that a
Blood money.: Nurs Times. 1997 May 21-27;93(21):41. Unique Identifier : AIDSLINE MED/97341452; Legge A
Nutrition and HIV infection.: Nurs Times. 1997 May 21-27;93(21):67-71. Unique Identifier : AIDSLINE MED/97341457; Sumpter J; Nightingale Institute, King's College, London.
Friends for life [interview by Eileen Fursland]: Nurs Times. 1997 Jun 4-10;93(23):17. Unique Identifier : AIDSLINE MED/97349427; Keegan C; Worlidge P
Assembly of a rod-shaped chimera of a trimeric GCN4 zipper and the HIV-1 gp41 ectodomain expressed in Escherichia coli.: Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6065-9. Unique Identifier : AIDSLINE MED/97322324; Weissenhorn W; Calder LJ; Dessen A; Laue T; Skehel JJ; Wiley DC; Laboratory of Molecular Medicine, The Children's Hospital, 320; Longwood Avenue, Boston, MA 02215, USA.; The HIV-1 envelope subunit gp41 plays a role in viral entry by initiating fusion of the viral and cellular membranes. A chimeric molecule was constructed centered on the ectodomain of gp41 without the fusion peptide, with a trimeric isoleucine zipper derived from GCN4 (pIIGCN4) on the N terminus and part of the trimer
Casein kinase II is a selective target of HIV-1 transcriptional inhibitors.: Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6110-5. Unique Identifier : AIDSLINE MED/97322333; Critchfield JW; Coligan JE; Folks TM; Butera ST; Retrovirus Diseases Branch, Division of Acquired Immunodeficiency; Syndrome, Sexually Transmitted Diseases, and Tuberculosis Laboratory; Research, Centers for Disease Control and Prevention, Atlanta, GA; 30333, USA. jkc6@cdc.gov; The identification of cellular factors that are required to complete various steps of the HIV-1 life cycle may lead to the development of new therapeutics. One key step, transcription from the integrated provirus, is inhibited by members of two distinct classes of compounds, the flavonoids and the benzothiophenes, via
The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ.: Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6307-12. Unique Identifier : AIDSLINE MED/97322368; Chesney J; Bacher M; Bender A; Bucala R; The Picower Institute for Medical Research, Laboratory of Medical; Biochemistry, Manhasset, NY 11030, USA.; Recent studies have identified a novel population of blood-borne cells, termed fibrocytes, that have a distinct cell surface phenotype (collagen+/CD13(+)/CD34(+)/CD45(+)), rapidly enter sites of tissue injury, and synthesize connective tissue matrix molecules. We found by flow cytometry that purified human fibrocytes
Reexamination of human T cell lymphotropic virus (HTLV-I/II) prevalence.: Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6403-7. Unique Identifier : AIDSLINE MED/97322385; Zucker-Franklin D; Pancake BA; Marmor M; Legler PM; Department of Medicine, New York University Medical Center, 550 First; Avenue, New York, NY 10016, USA.; In the United States , blood donors are being screened for infection with human T cell lymphotropic viruses I and II HTLV-I/II) by serologic means, which detect antibodies to the structural proteins of these viruses. Because patients with mycosis fungoides (MF) usually do not have such
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains.: Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6426-31. Unique Identifier : AIDSLINE MED/97322389; Lu Z; Berson JF; Chen Y; Turner JD; Zhang T; Sharron M; Jenks MH; Wang Z; Kim J; Rucker J; Hoxie JA; Peiper SC; Doms RW; James Graham Brown Cancer Center, University of Louisville,; Louisville, KY 40202, USA.; The chemokine receptor CXCR4 functions as a fusion coreceptor for T cell tropic and dual-tropic HIV-1 strains. To identify regions of CXCR4 that are important for coreceptor function, CXCR4-CXCR2 receptor chimeras were tested for the ability to support HIV-1 envelope (env) protein-mediated membrane fusion. Receptor ch
[Function of proline-rich regions in proteins and proline specific peptidases]: Tanpakushitsu Kakusan Koso. 1997 May;42(6):857-64. Unique Identifier : AIDSLINE MED/97282392; Maruyama S; National Institute of Bioscience and Human-Technology, Ibaraki, Japan.
[Pancreatitis during treatment of leishmaniasis with n-methylglucamine antimoniate in a subject infected with HIV]: Riv Eur Sci Med Farmacol. 1996 Mar-Apr;18(2):49-51. Unique Identifier : AIDSLINE MED/97320850; Trinchieri V; Ferone U; Monacelli M; Isceri L; Proietti F; Sorice F; Dipartimento di Mallattie Infettive e Tropicali, Universita degli; Studi La Sapienza, Roma.; In this study the authors report the case of HIV patients with visceral leishmaniasis. He presented a pancreatitis with evident clinical signs and high increase of amilasis (9876 U/L) the twelfth day of treatment with meglumine antimoniate. The interruption of therapy was followed by a rapid disappearance of signs and
[Cytomegalovirus colitis in AIDS]: Schweiz Rundsch Med Prax. 1997 Apr 9;86(15):630-1. Unique Identifier : AIDSLINE MED/97284354; Bassetti S; Medizinische Universitats-Poliklinik, Departement fur Innere Medizin,; Kantonsspital Basel.
HIV and the law.: RN. 1997 May;60(5):59-60, 63-4. Unique Identifier : AIDSLINE MED/97349488; Brooke PS; University of Utah College of Nursing, Salt Lake City, USA.
Delayed onset of pseudomembranous colitis after rifampin therapy.: South Med J. 1997 Jun;90(6):644-6. Unique Identifier : AIDSLINE MED/97335078; Byrd RP Jr; Roy TM; Ossorio MA; Fields CL; Division of Pulmonary Medicine, Veterans Affairs Medical Center,; Mountain Home, Tenn 87684-4000, USA.; Rifampin therapy is an infrequently reported cause of pseudomembranous colitis. A low index of suspicion may account for this lack of recognition. Awareness of this potentially hazardous complication of rifampin therapy is encouraged, especially since increasing numbers of patients infected with the human immunodefici
Immunopathology of human immunodeficiency virus infection in the gastrointestinal tract.: Springer Semin Immunopathol. 1997;18(4):515-33. Unique Identifier : AIDSLINE MED/97290083; Schneider T; Ullrich R; Zeitz M; Medical Clinic II, University of the Saarland, Homburg/Saar, Germany.
Sexually transmitted diseases: United States, 1995.: Stat Bull Metrop Insur Co. 1997 Apr-Jun;78(2):10-7. Unique Identifier : AIDSLINE MED/97280260; Mushinski M; Over the past two decades, the United States has experienced some dramatic changes in the rates of three classic sexually transmitted diseases (STDs) as well as the introduction of a variety of newer and more complex STD organisms. Rates of primary and secondary syphilis increased th
Evidence of an increasing AIDS burden in rural America.: Stat Bull Metrop Insur Co. 1997 Apr-Jun;78(2):2-9. Unique Identifier : AIDSLINE MED/97280259; Fordyce EJ; Thomas P; Shum R; Office of AIDS Surveillance, New York City Department of Health.; As the AIDS epidemic has matured in the United States , the characteristics of affected populations have shifted from a predominantly white homosexual/bisexual population to one now including increasingly more minorities, injecting drug users and women. Concomitant with the changing nat
Bronchoalveolar lavage cell profile in methotrexate induced pneumonitis.: Thorax. 1997 Apr;52(4):377-9. Unique Identifier : AIDSLINE MED/97339990; Schnabel A; Richter C; Bauerfeind S; Gross WL; Rheumatologiache Poliklinik, Medixiniache Universitat Lubeck, Germany.; BACKGROUND: Pneumonitis is a rare but potentially life threatening side effect of methotrexate treatment for rheumatoid arthritis which needs to be distinguished from interstitial lung disease due to rheumatoid arthritis. METHODS: To examine the value of bronchoalveolar lavage (BAL) in diagnosing methotrexate pneumoni
[Mycobacterium avium complex infections: the point on the treatments]: Therapie. 1997 Jan-Feb;52(1):65-71. Unique Identifier : AIDSLINE MED/97327138; Brandissou S; Hamel B; Veillet B; Kinowski JM; Yagoubi N; Bressolle F; Laboratoire de Pharmacocinetique, CHU Caremeau, Nimes, France.; Mycobacterium avium complex (MAC) infections are the most frequent opportunistic infections in AIDS. Since progress in antiretroviral drugs enables AIDS patients to survive longer, these infections involve an increasing number of sick people. Few controlled assays have evaluated the efficiency of several antibiotics.
[Rehabilitation after stroke. Programs at the Sunnaas hospital]: Tidsskr Nor Laegeforen. 1997 May 20;117(13):1923-5. Unique Identifier : AIDSLINE MED/97348733; Jensen AE; Osten PE; Stanghelle JK; Sunnaas sykehus, Nesoddtangen.; The article describes the rehabilitation programmes for stroke patients at Sunnaas Hospital, a Norwegian university hospital for rehabilitation. Patients with complex and less frequent problems following a cerebrovascular accident can attend this third line hospital for primary or secondary rehabilitation. In addition
Tropical aspects of viral hepatitis. Hepatitis C.: Trans R Soc Trop Med Hyg. 1997 Mar-Apr;91(2):121-4. Unique Identifier : AIDSLINE MED/97340246; Tibbs CJ; Department of Gastroenterology, Queen Mary's University Hospital,; London, UK.; This paper reviews our current understanding of hepatitis C infection in tropical countries. Since its discovery in 1989, hepatitis C has been recognized as an important disease in many tropical countries. In Egypt the prevalence in some sections of the population may-exceed 20%. In
Cyclospora cayetanensis in an asymptomatic patient infected with HIV and HTLV-1.: Trans R Soc Trop Med Hyg. 1997 Mar-Apr;91(2):175. Unique Identifier : AIDSLINE MED/97340261; Schubach TM; Neves ES; Leite AC; Araujo AQ; de Moura H; Evandro Chagas Hospital, Oswaldo Cruz Foundation (FIOCRUZ), Rio de; Janeiro, Brazil.
Treatment of surgically induced acute liver failure by transplantation of conditionally immortalized hepatocytes.: Transplantation. 1997 Jun 15;63(11):1541-7. Unique Identifier : AIDSLINE MED/97340869; Nakamura J; Okamoto T; Schumacher IK; Tabei I; Chowdhury NR; Chowdhury JR; Fox IJ; Department of Surgery, University of Nebraska Medical Center, Omaha; 68198, USA.; The shortage of human livers available for hepatocyte isolation limits its clinical application. The availability of cloned, conditionally immortalized hepatocytes that could be grown in culture but would lose their transformed phenotype and provide metabolic support upon transplantation would greatly facilitate the t
[Is the prevention of HIV/AIDS in Denmark efficient (letter; comment)]: Ugeskr Laeger. 1997 Jun 16;159(25):3975-7. Unique Identifier : AIDSLINE MED/97348789; Zachariae H
[HIV/AIDS development in Denmark and Sweden (letter; comment)]: Ugeskr Laeger. 1997 Jun 16;159(25):3977-8. Unique Identifier : AIDSLINE MED/97348790; Milfeldt M
Differential levels of mRNAs for cytokines, the interleukin-2 receptor and class II DR/DQ genes in ovine interstitial pneumonia induced by maedi visna virus infection.: Vet Pathol. 1997 May;34(3):204-11. Unique Identifier : AIDSLINE MED/97306594; Woodall CJ; Maclaren LJ; Watt NJ; Department of Veterinary Pathology, University of Edinburgh, UK.; The relative levels of selected cytokine, interleukin-2 receptor, class II DR and DQ RNAs, and maedi visna virus (MVV) RNA were measured by reverse-transcriptase polymerase chain reaction RT-PCR) in the lungs of sheep with natural maedi visna virus infection (n = 8) and a group of age/sex/breed-matched MVV seronegativ
The immunophenotypic characterization of bovine lymphomas.: Vet Pathol. 1997 May;34(3):222-5. Unique Identifier : AIDSLINE MED/97306596; Vernau W; Jacobs RM; Valli VE; Heeney JL; Department of Pathobiology, University of Guelph, ON, Canada.; A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle
FIV induced encephalopathy: early brain lesions in the absence of viral replication in monocyte/macrophages. A pathogenetic model.: Vet Immunol Immunopathol. 1997 Mar;55(4):263-71. Unique Identifier : AIDSLINE MED/97295826; Silvotti L; Corradi A; Brandi G; Cabassi A; Bendinelli M; Magnan M; Piedimonte G; Istituto di Anatomia Patologica Veterinaria, Universita di Parma,; Italy.; FIV induced encephalopathy represents a model for the study of the neuropathogenesis of AIDS. It has yet to be determined whether massive viral replication is a prerequisite for the development of early brain lesions. Using a drug delivery system developed by us, we have shown that early encephalic lesions appear in F
p53 mutation as a potential cellular factor for tumor development in enzootic bovine leukosis.: Vet Immunol Immunopathol. 1997 Mar;55(4):351-8. Unique Identifier : AIDSLINE MED/97295834; Ishiguro N; Furuoka H; Matsui T; Horiuchi M; Shinagawa M; Asahina M; Okada K; Department of Veterinary Public Health, Obihiro University of; Agriculture and Veterinary Medicine, Japan. ishiguro@obihiro.ac.jp; Mutations of p53 in the lymphocytes from peripheral blood and from tumoral lymph nodes in six naturally occurring bovine leukemia virus (BLV)-infected cows were examined. A point mutation of the p53 gene was found in three of six (50%) BLV-infected cows. These p53 gene mutations resulted in amino acid substitutions of
Phosphorylation of both phosphoacceptor sites in the HIV-1 Vpu cytoplasmic domain is essential for Vpu-mediated ER degradation of CD4.: Virology. 1997 May 26;232(1):207-16. Unique Identifier : AIDSLINE MED/97329091; Paul M; Jabbar MA; Department of Molecular Biology-NC20, Research Institute, The; Cleveland Clinic Foundation, Ohio 44195, USA.; Human immunodeficiency virus type 1 (HIV-1) Vpu is phosphorylated at two serine residues (Ser52 and Ser56) present within the acidic dodecapeptide region of the 54-aa cytoplasmic domain. Previous experiments have shown that Vpu phosphorylation is critical for the degradation of CD4 in the endoplasmic reticulum. In thi
Challenge of chimpanzees immunized with a recombinant canarypox-HIV-1 virus.: Virology. 1997 May 26;232(1):98-104. Unique Identifier : AIDSLINE MED/97329080; Girard M; van der Ryst E; Barre-Sinoussi F; Nara P; Tartaglia J; Paoletti E; Blondeau C; Jennings M; Verrier F; Meignier B; Fultz PN; Institut Pasteur, Paris, France.; To evaluate the potential protective efficacy of a live recombinant human immunodeficiency virus type 1 (HIV-1) canarypox vaccine candidate, two chimpanzees were immunized five times with ALVAC-HIV-1 vCP250, a recombinant canarypox virus that expresses the HIV-1[IIIB(LAI)] gp120/TM, gag, and protease gene products. On
Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers.: Acta Psychiatr Scand. 1997 Mar;95(3):212-21. Unique Identifier : AIDSLINE MED/97266050; Maes M; Smith R; Christophe A; Vandoolaeghe E; Van Gastel A; Neels H; Demedts P; Wauters A; Meltzer HY; University Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium; Recently, there have been some reports that changes in serum lipid composition may be related to suicide, major depression and immune-inflammatory responses. Findings from our laboratory suggest that major depression is accompanied by reduced formation of cholesteryl esters and perhaps by impairment of reverse cholest
[Molluscum contagiosum in immunodepressed patient]: Actas Urol Esp. 1997 Feb;21(2):171-4. Unique Identifier : AIDSLINE MED/97269420; Caballero Alcantara J; Padilla Leon M; Marchal Escalona C; Villar Alvarez E; Unidad de Urologia, Hospital Costa del Sol, Marbella, Malaga.; Molluscum contagiosum is a skin lesion caused by a poxviridae virus. Infection in children takes place through cutaneous contact while in adults results from sexual contact or under immunosuppression conditions. In immunosuppressed patients this infection is caused by opportunistic microorganisms and, basically, its a
Cyclopia: craniofacial appearance on MR and three-dimensional CT.: AJNR Am J Neuroradiol. 1997 Mar;18(3):543-6. Unique Identifier : AIDSLINE MED/97245752; Liu DP; Burrowes DM; Qureshi MN; Department of Radiology, beth Israel Medical Center, New York, NY; 10003, USA.; In a case of alobar holoprosencephaly, a neonate who died several minutes after birth was found to have multiple facial and intracranial malformations, including cyclopia. Postmortem MR and CT findings included a single midline orbit, with two globes that contained separate lenses supplied by a single optic nerve. The
The variable MR appearance of primary lymphoma of the central nervous system: comparison with histopathologic features.: AJNR Am J Neuroradiol. 1997 Mar;18(3):563-72. Unique Identifier : AIDSLINE MED/97245756; Johnson BA; Fram EK; Johnson PC; Jacobowitz R; Department of Radiology, David Grant Medical Center, Travis AFB, Calif; 94535, USA.; PURPOSE: To describe the MR features of primary central nervous system (CNS) lymphoma and to determine whether there is a correlation with histopathologic findings. METHODS: The MR images, pathologic specimens, and clinical records of 23 patients with primary CNS lymphoma were revi
Sclerosing mesenteritis: an unusual cause of abdominal pain in an HIV-positive patient.: Am J Gastroenterol. 1997 Jun;92(6):1059-60. Unique Identifier : AIDSLINE MED/97320686; Venkataramani A; Behling CA; Lyche KD; Department of Medicine, University of California, San Diego; 92103-8413, USA.; Sclerosing mesenteritis is a rare, idiopathic, and benign mesenteric lesion that is characterized by fat necrosis, fibrosis, and chronic inflammation. We report a case of sclerosing mesenteritis presenting as recurrent abdominal pain in an HIV-positive patient. Because of the wider differential diagnosis in such cases
Tuberculous meningitis at a large inner-city medical center.: Am J Med Sci. 1997 Jun;313(6):325-31. Unique Identifier : AIDSLINE MED/97329671; Porkert MT; Sotir M; Parrott-Moore P; Blumberg HM; Department of Medicine, Emory University School of Medicine, Atlanta,; GA 30303, USA.; Tuberculosis in the United States has become primarily an inner-city disease. We examined the epidemiology of culture-confirmed tuberculous meningitis among patients cared for at an urban public hospital in Atlanta. During an 11.5-year period (January 1984-June 1995) cerebrospinal flui
Nasal tuberculosis in the 20th century.: Am J Med Sci. 1997 Jun;313(6):332-5. Unique Identifier : AIDSLINE MED/97329672; Butt AA; Department of Medicine, Louisiana State University Medical Center, New; Orleans 70112, USA.; During the last decade, tuberculosis has reemerged as a major health problem in the United States . Much of the blame for this resurgence has been attributed to human immunodeficiency virus infection, although homelessness and deterioration of the social infrastructure have also been im
Geographic and seasonal variation in Mycobacterium avium bacteremia among North American patients with AIDS.: Am J Med Sci. 1997 Jun;313(6):341-5. Unique Identifier : AIDSLINE MED/97329674; Horsburgh CR Jr; Schoenfelder JR; Gordin FM; Cohn DL; Sullam PM; Wynne BA; Department of Medicine, Emory University, Atlanta, GA 30303, USA.; Analysis of geographic risk was performed for Mycobacterium avium complex (MAC) bacteremia among North American patients with AIDS. Monthly mycobacterial blood cultures were taken from patients who were placebo recipients in a prospective evaluation of MAC prophylaxis. Of 571 patients, 102 (17.9%) acquired MAC bactere
Similar serovar and drug susceptibility profiles among AIDS-related Mycobacterium avium isolates from diverse geographic locations.: Am J Med Sci. 1997 Jun;313(6):352-4. Unique Identifier : AIDSLINE MED/97329676; Jacobs NJ; Fordham Von Reyn C; Gine N; Dawson D; Department of Microbiology, Dartmouth Medical School, Hanover, NH; 03755-3842, USA. Nicholas.Jacobs@Dartmouth.edu; Serotyping was performed on Mycobacterium avium isolates from 40 AIDS patients from 5 geographic sites: Boston (17 patients), New Hampshire (4 patients), Finland (12 patients),
Use of the bacille Calmette-Guerin vaccination for the prevention of tuberculosis: renewed interest in an old vaccine.: Am J Med Sci. 1997 Jun;313(6):372-6. Unique Identifier : AIDSLINE MED/97329679; Cohn DL; Denver Disease Control Service, Denver Public Health, Colorado, USA.; The reemergence of tuberculosis, including the impact of HIV infection and multidrug-resistant tuberculosis, have renewed interest in the bacille Calmette-Guerin (BCG) vaccine. During the past 7 decades, numerous studies have shown variable efficacy of BCG vaccination, ranging from 0% to 80%. The BCG vaccine is more l
Immunization of HIV-infected adults with a three-dose series of inactivated Mycobacterium vaccae.: Am J Med Sci. 1997 Jun;313(6):377-83. Unique Identifier : AIDSLINE MED/97329680; Marsh BJ; Fordham von Reyn C; Arbeit RD; Morin P; Infectious Disease Section, Dartmouth-Hitchcock Medical Center,; Lebanon, NH 03756, USA.; Heat-killed Mycobacterium vaccae vaccine was administered in a 3-dose schedule to 12 HIV-infected adults with CD4 cell counts > or = 300/mm3. Local and systemic side effects were monitored. Delayed-type hypersensitivity to purified protein derivative and Mycobacterium avium sensitin was measured at baseline and after
A polymerase chain reaction-based assay for diagnosing varicella-zoster virus retinitis in patients with acquired immunodeficiency syndrome.: Am J Ophthalmol. 1997 Feb;123(2):157-64. Unique Identifier : AIDSLINE MED/97329646; Short GA; Margolis TP; Kuppermann BD; Irvine AR; Martin DF; Chandler D; Francis I. Proctor Foundation, University of California, San Francisco; Medical Center 94143-0944, USA.; PURPOSE: To develop a rapid, sensitive, and specific laboratory assay based on the polymerase chain reaction for the diagnosis of varicella-zoster virus retinitis in patients with acquired immunodeficiency syndrome (AIDS). METHODS: We developed and tested a polymerase chain reaction-based assay for the detection of va
Disciform keratitis: a case of herpes zoster sine herpete.: Am J Ophthalmol. 1997 Feb;123(2):254-5. Unique Identifier : AIDSLINE MED/97329659; Silverstein BE; Chandler D; Neger R; Margolis TP; Francis I. Proctor Foundation, University of California, San Francisco; Medical Center 94143-0944, USA.; PURPOSE: To describe a case of disciform keratitis in a patient with acquired immunodeficiency syndrome (AIDS) in which varicella-zoster virus was the causative agent. METHOD: Case report, Polymerase chain reaction-based assays for varicella-zoster virus, cytomegalovirus , and herpe
Decreased plasma glutamine level and CD4+ T cell number in response to 8 wk of anaerobic training.: Am J Physiol. 1997 May;272(5 Pt 1):E788-95. Unique Identifier : AIDSLINE MED/97319274; Hack V; Weiss C; Friedmann B; Suttner S; Schykowski M; Erbe N; Benner A; Bartsch P; Droge W; Division of Immunochemistry, German Cancer Research Institute,; Heidelberg, Germany.; The purpose of the present study was to investigate the role of plasma amino acids and glutathione (GSH) on the absolute number of leukocyte and lymphocyte subpopulations in response to different training programs. Healthy untrained subjects were randomly assigned to an 8-wk aerobic (AET) or anaerobic (ANT) exercise t
RANTES inhibits HIV-1 replication in human peripheral blood monocytes and alveolar macrophages.: Am J Physiol. 1997 May;272(5 Pt 1):L1025-9. Unique Identifier : AIDSLINE MED/97319367; Coffey MJ; Woffendin C; Phare SM; Strieter RM; Markovitz DM; Division of Pulmonary and Critical Care Medicine, University of; Michigan Medical Center, Ann Arbor 48109, USA.; Infection with human immunodeficiency virus (HIV)-1 most often leads to the development of acquired immune deficiency syndrome, which may manifest with opportunistic infections, many of which occur in the lung. Mononuclear phagocytes infected by HIV-1, being relatively resistant to its cytopathic effects, potentially
Kaposi's sarcoma-associated herpesvirus and human herpesvirus 8 KSHV/HHV8)-associated lymphoma of the bowel. Report of two cases in HIV-positive men with secondary effusion lymphomas.: Am J Surg Pathol. 1997 Jun;21(6):719-24. Unique Identifier : AIDSLINE MED/97343022; DePond W; Said JW; Tasaka T; de Vos S; Kahn D; Cesarman E; Knowles DM; Koeffler HP; Department of Pathology, Truman Medical Center, Kansas City, Missouri,; USA.; This report describes two cases of Kaposi s sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8)-associated lymphomas that primarily involved the large bowel and that secondarily caused malignant effusions. Involvement of the gastrointestinal tract is of interest because epidemiologic evidence suggests that
A nodal gamma/delta T-cell lymphoma with an association of Epstein-Barr virus.: Am J Surg Pathol. 1997 Jun;21(6):729-36. Unique Identifier : AIDSLINE MED/97343024; Kagami Y; Nakamura S; Suzuki R; Yatabe Y; Okada Y; Kobayasi T; Taniwaki M; Seto M; Ogura M; Suchi T; Department of Hematology and Chemotherapy, Aichi Cancer Center; Hospital, Nagoya, Japan.; The postthymic gamma/delta T-cell lymphoma is rare, and most occur as extranodal tumors, e.g., in hepatosplenic or cutaneous forms. We here report an unusual nodal case that initially presented as a T-zone lymphoma. The neoplasm recurred as systemic lymphadenopathy 25 months after complete remission with terminal high
Detection of human papillomavirus DNA in keratoacanthomas by polymerase chain reaction.: Am J Dermatopathol. 1997 Feb;19(1):10-5. Unique Identifier : AIDSLINE MED/97209348; Hsi ED; Svoboda-Newman SM; Stern RA; Nickoloff BJ; Frank TS; Department of Pathology, University of Michigan Hospitals, Ann Arbor,; Michigan, USA.; The etiology of keratoacanthomas is unknown, but human papillomavirus (HPV) has been suspected to be involved in the pathogenesis of this lesion because koilocytic changes may be observed and because HPV has been found in cutaneous squamous-cell carcinomas and premalignant keratoses in immunosuppressed patients. We an
Leishmaniasis and Kaposi's sarcoma in an HIV-infected patient [letter; comment]: Am J Dermatopathol. 1997 Feb;19(1):101-3. Unique Identifier : AIDSLINE MED/97209365; Abajo P; Buezo GF; Fraga J; Sanz J; Dauden E
AIDS-associated B-cell non-Hodgkin's lymphoma masquerading as a cutaneous T-cell neoplasm: an aberrant immunophenotype requiring comprehensive analysis for lineage resolution.: Am J Dermatopathol. 1997 Feb;19(1):66-72. Unique Identifier : AIDSLINE MED/97209357; Aboulafia D; Gown AM; Kidd P; Section of Hematology/Oncology, Virginia Mason Medical Center,; Seattle, WA 98111, USA.; An increased prevalence of intermediate- and high-grade B-cell non-Hodgkin s lymphoma (NHL) is a major manifestation of the disease spectrum associated with human immunodeficiency virus HIV) infection. Rarely, lymphoproliferations are of T-cell, null cell, or mixed-lineage phenotyp
Papular urticaria: a histopathologic study of 30 patients.: Am J Dermatopathol. 1997 Apr;19(2):119-26. Unique Identifier : AIDSLINE MED/97275934; Jordaan HF; Schneider JW; Department of Dermatology, Faculty of Medicine, University of; Stellenbosch, Tygerberg Hospital, South Africa.; Papular urticaria is the result of hypersensitivity (id-reaction) to bites from certain insects such as mosquitoes gnats, fleas, mites, and bedbugs. Papular urticaria is common in childhood and is characterized by symmetrically distributed pruritic papules and papulovesicles. Scratching causes erosions and ulcerations
A microtiter colorimetric assay for the HIV-1 protease.: Anal Biochem. 1997 Jun 1;248(2):246-50. Unique Identifier : AIDSLINE MED/97321019; Stebbins J; Debouck C; Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals,; King of Prussia, Pennsylvania 19406, USA.; We have developed a novel colorimetric assay for the HIV-1 protease that is suitable for high-throughput screening of inhibitors. This assay utilizes two nonenzymatic reaction steps, which are carried out in succession following enzymatic hydrolysis of a synthetic peptide. The first step involves a carbamylation react
A nosocomial outbreak of multidrug-resistant tuberculosis.: Ann Intern Med. 1997 Jul 1;127(1):32-6. Unique Identifier : AIDSLINE MED/97339912; Kenyon TA; Ridzon R; Luskin-Hawk R; Schultz C; Paul WS; Valway SE; Onorato IM; Castro K; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; BACKGROUND: An outbreak of seven cases (in six patients and one health care worker, all of whom had AIDS) of multidrug-resistant tuberculosis occurred in a hospital in Chicago. The hospital had a respirator-fit testing program but no acid-fast bacilli isolation rooms. OBJECTIVE: To identify risk factors for transmissi
Update in general internal medicine.: Ann Intern Med. 1997 Jul 1;127(1):43-51. Unique Identifier : AIDSLINE MED/97339914; Sheffield JV; Larson EB; Harborview Medical Center, Seattle, Washington, USA.
Human T-cell lymphotropic virus type I-associated facial nerve palsy in Trinidad and Tobago.: Ann Neurol. 1997 Jun;41(6):806-9. Unique Identifier : AIDSLINE MED/97332880; Bartholomew C; Cleghorn F; Jack N; Edwards J; Blattner W; University of the West Indies Department of Medicine, Port of Spain,; Trinidad, West Indies.; To assess the association of the human T-cell lymphotropic virus type I (HTLV-I) and idiopathic facial nerve palsy of the lower motor neuron type, we studied 78 patients consecutively admitted to the Port of Spain General Hospital in
Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years.: Antimicrob Agents Chemother. 1997 Apr;41(4):757-62. Unique Identifier : AIDSLINE MED/97242485; Winters MA; Shafer RW; Jellinger RA; Mamtora G; Gingeras T; Merigan TC; Center for AIDS Research, Stanford University, California, USA.; The genetic mechanisms of human immunodeficiency virus type 1 HIV-1) resistance to dideoxyinosine (ddI) in vivo have been described based on data from primary HIV-1 isolates. To better define the spectrum of HIV-1 reverse transcriptase (RT) changes occurring during ddI therapy, we determined the genotype and ddI susce
In vitro and in vivo resistance of Leishmania infantum to meglumine antimoniate: a study of 37 strains collected from patients with visceral leishmaniasis.: Antimicrob Agents Chemother. 1997 Apr;41(4):827-30. Unique Identifier : AIDSLINE MED/97242499; Faraut-Gambarelli F; Piarroux R; Deniau M; Giusiano B; Marty P; Michel G; Faugere B; Dumon H; Laboratoire de Parasitologie-Mycologie et Unite INSERM 399, Faculte de; Medecine, Hopital d'Enfants de La Timone, Marseille, France.; Primary and secondary unresponsiveness to meglumine has long been described in human visceral leishmaniasis. However, no studies have been performed to elucidate if these therapeutic failures were due to strain variability in meglumine sensitivity or were related to host factors. We have studied the in vitro sensitivi
Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates.: Antimicrob Agents Chemother. 1997 Apr;41(4):831-7. Unique Identifier : AIDSLINE MED/97242500; Buckheit RW Jr; Snow MJ; Fliakas-Boltz V; Kinjerski TL; Russell JD; Pallansch LA; Brouwer WG; Yang SS; Virology Research Group, Southern Research Institute-Frederick; Research Center, Maryland 21701, USA. buckheit@sri.org; The structure-activity relationships of a series of compounds related to the nonnucleoside reverse transcriptase (RT) inhibitor NNRTI) oxathiin carboxanilide have been described (R. W. Buckheit, Jr., T. L. Kinjerski, V. Fliakas-Boltz, J. D. Russell, T. L. Stup, L. A. Pallansch, W. G. Brouwer, D. C. Dao, W. A. Harrison
Early effects of ganciclovir therapy on the quantity of cytomegalovirus DNA in leukocytes of immunocompromised patients.: Antimicrob Agents Chemother. 1997 Apr;41(4):860-2. Unique Identifier : AIDSLINE MED/97242508; Boivin G; Quirk MR; Kringstad BA; Germain M; Jordan MC; Department of Microbiology, Universite Laval, Quebec City, Quebec,; Canada.; The cytomegalovirus ( CMV ) DNA load in leukocytes was measured in 26 immunocompromised patients with CMV disease before and after 10 days of intravenous ganciclovir therapy. Before therapy, the circulating DNA burden of bone m
Effects of RP 55778, a tumor necrosis factor alpha synthesis inhibitor, on antiviral activity of dideoxynucleosides.: Antimicrob Agents Chemother. 1997 Apr;41(4):875-7. Unique Identifier : AIDSLINE MED/97242513; Clayette P; Dereuddre-Bosquet N; Martin M; Fretier P; Dormont D; Service de Neurovirologie, CEA, DSV/DRM/SSA, IPSC, Fontenay aux Roses,; France. clayette@dsvidf.cea.fr; Tumor necrosis factor alpha (TNF-alpha) is overexpressed during human immunodeficiency virus (HIV) infection. RP 55778, a TNF-alpha synthesis inhibitor, decreases HIV replication in monocytes/macrophages. Therapeutic use of RP 55778 in vivo, like that of other biological response modifiers, would theoretically require
AZT blocks down-regulation of IL-2 and IFN-gamma gene expression in HIV acutely infected cells.: Arch Virol. 1997;142(5):1035-43. Unique Identifier : AIDSLINE MED/97335202; Fan J; Li P; Kok TW; Burrell CJ; National Centre for HIV Virology Research, Institute of Medical and; Veterinary Science, Adelaide, Australia.; HIV infection causes dysregulation of cytokine gene expression in CD4+ T cells of the infected host. Azidothymidine ( AZT ) inhibits HIV replication by blocking reverse transcription. Using a one-stop cell-to-cell HIV infection model, we have investigat
Interleukin-18 activates NF-kappaB in murine T helper type 1 cells.: Biochem Biophys Res Commun. 1997 May 19;234(2):454-7. Unique Identifier : AIDSLINE MED/97320441; Matsumoto S; Tsuji-Takayama K; Aizawa Y; Koide K; Takeuchi M; Ohta T; Kurimoto M; Fujisaki Institute, Hayashibara Biochemical Labs, Inc., Okayama,; Japan.; Interleukin-18 (IL-18) activated T helper type 1 (Th1) cells, OVA#4, and induced production of interleukin-2 ( IL-2 ) in costimulation with anti-CD3 antibody. Upon stimulation with IL-18, IkappaB disappeared from cytoplasm and subsequently nuclear factor-kappaB (NF-kappa
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives.: Biochem Biophys Res Commun. 1997 May 19;234(2):458-64. Unique Identifier : AIDSLINE MED/97320442; Esnouf RM; Stuart DI; De Clercq E; Schwartz E; Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium. robert@s151h16.rega.kuleuven.ac.be; The (thio)carboxanilide derivatives are potent and selective inhibitors of HIV-1 reverse transcriptase (RT) and have a favourable antiviral activity spectrum. To understand better their mode of action, and to provide a structural basis for further improvement, models of RT complexed with four thio)carboxanilide inhibi
[Neurosyphilis with multiple gummas and AIDS. Report of a case]: Ann Pathol. 1997 Apr;17(2):116-9. Unique Identifier : AIDSLINE MED/97317656; Maurage CA; Gambarelli D; Nicoli F; Gastaut JL; Pellissier JF; Service d'Anatomie Pathologique et de Neuropathologie, Hopital de la; Timone.; The incidence of neurosyphilis has been increasing since AIDS has appeared but acute gummatous necrotizing progression is so far exceptional. We report a second case of quaternary neurosyphilis in a 29-year-old patient without serologic nor CT scan evidence of treponema. Diagnosing neurosyphilis is particularly diff
Simple monitoring of antiretroviral therapy with a signal-amplification-boosted HIV-1 p24 antigen assay with heat-denatured plasma.: AIDS. 1997 May;11(6):F47-52. Unique Identifier : AIDSLINE MED/97288649; Boni J; Opravil M; Tomasik Z; Rothen M; Bisset L; Grob PJ; Luthy R; Schupbach J; Swiss National Centre for Retroviruses, University of Zurich,; Switzerland.; OBJECTIVE: Virus load determination has become indispensable for the management of HIV patients, but depends on expensive assays of a low throughput. We evaluated whether a highly improved HIV-1 p24 antigen detection procedure which involves heat-mediated immune complex dissociation and signal-amplification-boosted en
The puzzle of HIV-1 subtypes in Africa [editorial]: AIDS. 1997 May;11(6):705-12. Unique Identifier : AIDSLINE MED/97288650; Janssens W; Buve A; Nkengasong JN
The beta-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line.: AIDS. 1997 May;11(6):713-21. Unique Identifier : AIDSLINE MED/97288651; Albini A; Paglieri I; Orengo G; Carlone S; Aluigi MG; DeMarchi R; Matteucci C; Mantovani A; Carozzi F; Donini S; Benelli R; Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.; OBJECTIVE: Kaposi s sarcoma (KS), a condition often associated with HIV infection, is more common in men than in women; pregnancy and sex hormones could be involved. Urinary human chorionic gonadotrophin (hCG) has been reported to inhibit the growth of KS cell lines, with great variability among preparations. Urinary
Diagnosis of infections caused by Enterocytozoon bieneusi and Encephalitozoon intestinalis using polymerase chain reaction in stool specimens [see comments]: AIDS. 1997 May;11(6):723-6. Unique Identifier : AIDSLINE MED/97288652; Liguory O; David F; Sarfati C; Schuitema AR; Hartskeerl RA; Derouin F; Modai J; Molina JM; Division of Infectious Diseases, Hopital Saint-Louis, Paris, France.; OBJECTIVE: To study the usefulness of polymerase chain reaction PCR) for the species identification of microsporidia in stool specimens obtained from HIV-infected patients with Enterocytozoon bieneusi or Encephalitozoon intestinalis infections. SETTING: Infectious disease clinic in a university hospital. PATIENTS: Thi
Upregulation of urokinase-type plasminogen activator by endogenous and exogenous HIV-1 Tat protein in tumour cell lines derived from BK virus/tat-transgenic mice.: AIDS. 1997 May;11(6):727-36. Unique Identifier : AIDSLINE MED/97288653; Rusnati M; Coltrini D; Campioni D; Tanghetti E; Corallini A; Barbanti-Brodano G; Giuliani R; Gibellini D; Presta M; Department of Biomedical Sciences and Biotechnology, University of; Brescia, Italy.; OBJECTIVE: To demonstrate that Tat modulates the plasminogen-dependent proteolytic activity of tumour cell lines derived from BK virus (BKV)/tat-transgenic mice by affecting the production of plasminogen activators (PA) and the PA inhibitor PAI)-1 and to demonstrate that this occurs through mechanism(s) that are disti
CD8+ cells from HIV-2-infected baboons control HIV replication.: AIDS. 1997 May;11(6):737-46. Unique Identifier : AIDSLINE MED/97288654; Blackbourn DJ; Locher CP; Ramachandran B; Barnett SW; Murthy KK; Carey KD; Brasky KM; Levy JA; Department of Medicine, University of California, San Francisco 94143,; USA.; OBJECTIVE: To analyze the CD8+ cell antiviral immune response in HIV-2-infected baboons. DESIGN: Baboons were infected with clinical isolates of HIV-2, CD8+ cells were isolated from phytohemagglutinin (PHA)-stimulated baboon peripheral blood mononuclear cells (PBMC). These cells were cultured with PHA-stimulated CD4+
The effect of immunization with inactivated hepatitis A vaccine on the clinical course of HIV-1 infection: 1-year follow-up.: AIDS. 1997 May;11(6):747-9. Unique Identifier : AIDSLINE MED/97288655; Bodsworth NJ; Neilsen GA; Donovan B; Academic Unit of Sexual Health Medicine, Sydney Sexual Health Centre,; Sydney Hospital, NSW, Australia.; OBJECTIVE: To determine the long-term safety of inactivated hepatitis A virus (HAV) vaccine in men infected with HIV-1. DESIGN: A 1-year prospective case-control study. SETTING: Targeted primary care and sexually transmitted diseases clinics. PATIENTS: Ninety HIV-1-positive patients who participated in an earlier effi
Characterization and natural course of cardiac autonomic nervous dysfunction in HIV-infected patients.: AIDS. 1997 May;11(6):751-7. Unique Identifier : AIDSLINE MED/97288656; Becker K; Gorlach I; Frieling T; Haussinger D; Department of Gastroenterology and Infectious Diseases, Heinrich Heine; University Medical Centre, Dusseldorf, Germany.; OBJECTIVE: To examine the degree, pattern, and natural history of cardiac autonomic nervous dysfunction in patients infected with HIV. DESIGN: Cross-sectional and prospective longitudinal cohort study. SETTING: Primary care and tertiary referral university centre. PARTICIPANTS: Thirty-five consecutive HIV-infected pat
A dose comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis.: AIDS. 1997 May;11(6):759-63. Unique Identifier : AIDSLINE MED/97288657; De Wit S; Dupont B; Cartledge JD; Hawkins DA; Gazzard BG; Clumeck N; Denning DW; Saint-Pierre Hospital, Brussels, Belgium.; OBJECTIVE: This multicentre study evaluated the clinical efficacy and tolerability of D0870 in treating oropharyngeal candidiasis in HIV-positive patients who had no history of clinical resistance to fluconazole. METHODS: Three regimens were evaluated in two phases. In phase I a 50 mg initial dose was followed by 10 m
Functionally relevant changes occur in HIV-infected individuals' alveolar macrophages prior to the onset of respiratory disease.: AIDS. 1997 May;11(6):765-72. Unique Identifier : AIDSLINE MED/97288658; Lipman MC; Johnson MA; Poulter LW; Department of Thoracic Medicine, Royal Free Hospital and School of; Medicine, London, UK.; OBJECTIVE: We have compared the phenotypic and functional changes found in alveolar macrophages recovered from the lungs of 39 HIV-positive individuals with no respiratory disease with those from 33 HIV-positive individuals with pneumonitis and 31 healthy controls. METHODS: Bronchoalveolar lavage (BAL) cell cytospin p
Repeat HIV testers at a London same-day testing clinic.: AIDS. 1997 May;11(6):773-81. Unique Identifier : AIDSLINE MED/97288659; Norton J; Elford J; Sherr L; Miller R; Johnson MA; Royal Free Hampstead NHS Trust Hospital, London, UK.; OBJECTIVE: To compare the characteristics of repeat HIV testers with first-time testers in a National Health Service HIV testing clinic in London. SUBJECTS AND METHODS: A self-administered questionnaire was distributed to clinic attenders between September 1995 and January 1996. The sample was stratified by gender and
Assessing participation bias in a sexual behaviour survey: implications for measuring HIV risk.: AIDS. 1997 May;11(6):783-90. Unique Identifier : AIDSLINE MED/97288660; Copas AJ; Johnson AM; Wadsworth J; Department of Sexually Transmitted Diseases, University College; Medical School, London, UK.; OBJECTIVES: To assess the likelihood of participation bias in a large population-based sex survey, and its possible effect on estimates of HIV risk behaviours. DESIGN: Construction of general hypotheses about non-participants through comparisons of willing and unwilling participants. METHODS: British adults aged 16-59
Adolescents, sexual behaviour and HIV-1 in rural Rakai district, Uganda.: AIDS. 1997 May;11(6):791-9. Unique Identifier : AIDSLINE MED/97288661; Konde-Lule JK; Wawer MJ; Sewankambo NK; Serwadda D; Kelly R; Li C; Gray RH; Kigongo D; Institute of Public Health, Makerere University, Kampala, Uganda.; OBJECTIVES: To describe the epidemiology of HIV-1 infection among adolescents aged 13-19 years, in rural Rakai district, Uganda . STUDY DESIGN: Baseline survey and 2-year follow-up (1990-1992) of adolescents in a population-based, open rural cohort. METHODS: Annual enumeration and b
HIV-associated adult mortality in a rural Tanzanian population.: AIDS. 1997 May;11(6):801-7. Unique Identifier : AIDSLINE MED/97288662; Todd J; Balira R; Grosskurth H; Mayaud P; Mosha F; ka-Gina G; Klokke A; Gabone R; Gavyole A; Mabey D; Hayes R; African Medical and Research Foundation, Mwanza, Tanzania.; OBJECTIVE: To measure HIV-associated adult mortality in a rural population in Tanzania . To record the signs and symptoms associated with deaths of HIV-positive adults. DESIGN: Prospective cohort study conducted in the context of a randomized controlled trial to evaluate the impac
Efficiency and rationality in the planning of health care for people with AIDS: an application of the balance of care approach. North-East Italian Group for Planning of AIDS Health Care.: AIDS. 1997 May;11(6):809-16. Unique Identifier : AIDSLINE MED/97288663; Tramarin A; Tolley K; Campostrini S; de Lalla F; Infectious Diseases Department, San Bortolo Hospital, Vicenza, Italy.; OBJECTIVE: To demonstrate the application of an approach for assessing efficiency and rationality in the use of resources for the care of patients with AIDS (PWA), using data for north-east Italy . DESIGN: An economic methodology, the balance of care (BoC) approach, enabled identific
Polymerase chain reaction of stool: a powerful tool for specific diagnosis and epidemiologic investigation of enteric microsporidia infections [editorial; comment]: AIDS. 1997 May;11(6):817-8. Unique Identifier : AIDSLINE MED/97288664; Owen RL
Vaccine therapy in early HIV-1 infection using a recombinant canarypox virus expressing gp160MN (ALVAC-HIV): a double-blind controlled randomized study of safety and immunogenicity [letter]: AIDS. 1997 May;11(6):819-20. Unique Identifier : AIDSLINE MED/97288665; Tubiana R; Gomard E; Fleury H; Gougeon ML; Mouthon B; Picolet H; Katlama C
Completeness of reporting of AIDS associated with invasive cervical carcinoma [letter; comment] [see comments]: AIDS. 1997 May;11(6):820-1. Unique Identifier : AIDSLINE MED/97288666; Simon PA; Bruce RC; Bunch G
HIV exposure category and invasive cervical carcinoma in Italy [letter; comment]: AIDS. 1997 May;11(6):821-2. Unique Identifier : AIDSLINE MED/97288667; Serraino D; Pezzotti P; Rezza G
Nitric oxide production and disease evolution in HIV-infected hemophilic patients [letter]: AIDS. 1997 May;11(6):822-4. Unique Identifier : AIDSLINE MED/97288668; de Bracco MM; Felippo M; Vernava D; Perez-Bianco R; de Tezanos Pinto M
High prevalence of cutaneous viral infections in AIDS patients with Kaposi's sarcoma: insight into the role of human herpesvirus 8? [letter]: AIDS. 1997 May;11(6):824-6. Unique Identifier : AIDSLINE MED/97288669; Simonart T; Van Vooren JP; Noel JC; Liesnard C; Farber CM; Parent D
A partial explanation for the low number of vertically acquired AIDS cases in Amsterdam, The Netherlands [letter]: AIDS. 1997 May;11(6):826-7. Unique Identifier : AIDSLINE MED/97288670; van den Hoek A; van Haastrecht H; Spijkerman I; Coutinho R
Laboratory diagnosis of antibiotic resistant Mycobacterium bovis within 48 h: a qualitative change in the approach to mycobacterial diseases in AIDS patients [letter]: AIDS. 1997 May;11(6):827-8. Unique Identifier : AIDSLINE MED/97288671; Espinosa de los Monteros LE; Gomez-Mampaso E; Cobo J; Guerrero A; Baquero F; Blazquez J
Survival of AIDS patients in an academic unit in Athens, Greece [letter; comment]: AIDS. 1997 May;11(6):828-9. Unique Identifier : AIDSLINE MED/97288672; Dimitrakopoulos A; Kosmopoulou O; Foukaneli T; Papalambrou C; Kalapothaki V; Kordossis T
Looking for men in all the wrong places...: HIV prevention small-group programs do not reach high risk gay men [letter]: AIDS. 1997 May;11(6):829-30. Unique Identifier : AIDSLINE MED/97288673; Hoff CC; Kegeles SM; Acree M; Stall R; Paul J; Ekstrand M; Coates TJ
Genotypic variants of HIV-1 from peripheral blood and lungs of AIDS patients [letter]: AIDS. 1997 May;11(6):831-2. Unique Identifier : AIDSLINE MED/97288674; Alimohammadi A; Coker R; Miller R; Mitchell D; Williamson J; Clarke J
Reducing the incidence of Pneumocystis carinii pneumonia: a persisting challenge [letter]: AIDS. 1997 May;11(6):832-3. Unique Identifier : AIDSLINE MED/97288675; Pradier C; Pesce A; Taillan B; Roger PM; Bentz L; Dellamonica P
Modelling the AIDS incubation time: evaluation of three right censoring strategies [letter]: AIDS. 1997 May;11(6):834-5. Unique Identifier : AIDSLINE MED/97288676; van Benthem BH; Veugelers PJ; Schechter MT; Kaldor JM; Page-Shafter KA; van Griensven GJ
Mutations associated with zidovudine resistance in HIV-1 among recent seroconvertors [letter]: AIDS. 1997 May;11(6):835-6. Unique Identifier : AIDSLINE MED/97288677; Quigg M; Rebus S; France AJ; McMenamin J; Darby G; Leigh Brown AJ
Side-effects of ritonavir and its combination with saquinavir with special regard to renal function [letter]: AIDS. 1997 May;11(6):836-8. Unique Identifier : AIDSLINE MED/97288678; Witzke O; Plentz A; Schafers RF; Reinhardt W; Heemann U; Philipp T
Enhanced expression of activation antigens HLA-DR and CD69 on gamma delta T cells but impaired interleukin-2-induced upregulation in HIV-1 infection [letter]: AIDS. 1997 May;11(6):838-9. Unique Identifier : AIDSLINE MED/97288679; Grottrup-Wolfers E; Strzelecki R; Grunewald T; Schuler-Maue W; Ruf B
Absence of detectable maternal DNA and identification of proviral HIV in the cord blood of two infants who became HIV-infected [letter] [corrected and republished in 1997 Jul;11(8):840-1]: AIDS. 1997 May;11(6):840-1. Unique Identifier : AIDSLINE MED/97288680; De Andreis C; Simoni G; Castagna C; Sacchi L; Sirchia SM; Garagiola I; Persico T; Serafini P; Pardi G; Semprini AE
Quarterly Communicable Disease Review July to September 1996. From the PHLS Communicable Disease Surveillance Centre.: J Public Health Med. 1997 Mar;19(1):116-20. Unique Identifier : AIDSLINE MED/97284151
Effect of the oral anti-ulcer agent, cimetidine, on HIV type 1 replication [letter]: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):281-2. Unique Identifier : AIDSLINE MED/97225053; Bourinbaiar AS; Fruhstorfer EC
Lecithinized superoxide dismutase: an inhibitor of human immunodeficiency virus replication.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):283-90. Unique Identifier : AIDSLINE MED/97225054; Premanathan M; Nakashima H; Igarashi R; Mizushima Y; Yamada K; Department of Microbiology and Immunology, Kagoshima University School; of Dentistry, Japan.; Superoxide dismutase (SOD) is an enzyme used in the treatment of oxygen radical-related diseases. Lecithinization of SOD enhances its pharmacological activity. Lecithinized SOD (PC-SOD) inhibits human immunodeficiency virus (HIV) types 1 and 2 in MT-4 cells. HIV-1-infected MT-4 cells were cultured for 5 days in the pr
Effects of cation substitutions on reverse transcriptase and on human immunodeficiency virus production.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):291-9. Unique Identifier : AIDSLINE MED/97225055; Filler AG; Lever AM; Department of Cellular and Molecular Sciences, St. George's Hospital; Medical School, London, UK.; Reverse transcription is a key aspect of the retroviral life cycle. The enzyme reverse transcriptase requires divalent cations, manganese or magnesium, for function. In some cation-dependent systems substitution of a physiological metal by a nonphysiological metal has been shown to work. We investigated the effect of
A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):301-4. Unique Identifier : AIDSLINE MED/97225056; Alexander LN; Wilcox CM; Department of Medicine, Emory University School of Medicine, Atlanta,; Georgia, USA.; Thalidomide appears to be highly effective for oropharyngeal apthous ulcers in HIV-infected patients. However, there are limited data regarding the use of this drug for the treatment of HIV-associated idiopathic esophageal ulcer(s) (IEU). Twelve HIV-infected patients with esophageal symptoms and IEU as defined by prev
The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):305-15. Unique Identifier : AIDSLINE MED/97225057; Timpone JG; Wright DJ; Li N; Egorin MJ; Enama ME; Mayers J; Galetto G; Division of AIDS, NIAID, NIH, Bethesda, Maryland 20892, USA.; This randomized, open-labeled, multicenter study was designed to assess safety and pharmacokinetics of dronabinol (Marinol) tablets and megestrol acetate (Megace) micronized tablets, alone and in combination, for treatment of HIV wasting syndrome. Weight and quality of life data were also collected. Fifty-two patients
Correlation of titer of antibody to principal neutralizing domain of HIVMN strain with disease progression in Japanese hemophiliacs seropositive for HIV type 1.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):317-26. Unique Identifier : AIDSLINE MED/97225058; Yamanaka T; Fujimura Y; Ishimoto S; Yoshioka A; Konishi M; Narita N; Mimaya J; Meguro T; Nakasone T; Okamoto Y; Yoshizaki H; Yamada K; Honda M; Department of Blood Transfusion Service, Nara Medical University,; Japan.; With the use of the principal neutralizing determinant (PND) peptide-based ELISA to measure anti-PND antibodies that specifically bound synthetic peptides derived from HIVIIIB, HIVMN, HIVRF, HIVSC, HIVWJM-2, HIVAf1l.con, or HIVAf2.con, type-specific antibodies to the HIVMN peptide were studied in 350 serum specimens f
Prospective longitudinal analysis of viral load and surrogate markers in relation to clinical progression in HIV type 1-infected persons.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):327-35. Unique Identifier : AIDSLINE MED/97225059; Bruisten SM; Frissen PH; Van Swieten P; Harrigan PR; Kinghorn I; Larder B; Weigel HM; De Vries E; Regez RM; Henrichs JH; Koot M; Huisman JG; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, Amsterdam, The; Netherlands.; The temporal relationship between viral and surrogate markers and clinical status was analyzed prospectively every 8 weeks in 34 asymptomatic HIV-1-infected persons. After 3 years, 25 persons remained clinically healthy whereas 9 persons showed clinical progression. In accordance with other reports we found that at st
Comparable biological and molecular determinants in HIV type 1-infected long-term nonprogressors and recently infected individuals.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):337-41. Unique Identifier : AIDSLINE MED/97225060; Balotta C; Bagnarelli P; Riva C; Valenza A; Antinori S; Colombo MC; Sampaolesi R; Violin M; de Pasquale MP; Moroni M; Clementi M; Galli M; Clinic of Infectious Diseases, University of Milan, Italy.; Human immunodeficiency virus type 1 (HIV-1) isolability, rate of replication, phenotype, plasma viremia, and specific intracellular transcripts were cross-sectionally analyzed in 61 HIV-1-seropositive individuals to evaluate the correlations between the virological and molecular correlates of protection and progressio
Dynamics of the HIV-1 subtype distribution in the Swedish HIV-1 epidemic during the period 1980 to 1993.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):343-5. Unique Identifier : AIDSLINE MED/97225061; Sonnerborg A; Durdevic S; Giesecke J; Sallberg M; Division of Clinical Virology, Karolinska Institutet, Huddinge; University Hospital, Sweden.; We have investigated the distribution of the major subtypes, or clades (A to E), in the Swedish human immunodeficiency virus type 1 (HIV-1) epidemic between the years 1980 to 1993, using gp120 V3 domain serotyping and genotyping. Until 1984 the Swedish HIV-1 epidemic was almost exclusively caused by HIV-1 subtype B. D
Mucosal transmission of cell-associated and cell-free feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):347-55. Unique Identifier : AIDSLINE MED/97225062; Burkhard MJ; Obert LA; O'Neil LL; Diehl LJ; Hoover EA; Department of Pathology, College of Veterinary Medicine, Colorado; State University, Fort Collins 80523, USA.; Mucosal infection by feline immunodeficiency virus (FIV) was assessed via a single exposure of the vaginal or rectal mucosa to either infectious peripheral blood mononuclear cells (PBMCs), infectious plasma, or cell-free cultured virus. All cats inoculated with cell-free cultured virus (100 or 400 TCID) and 9 of 10 ca
HIV type 1 isolate Z321, the strain used to make a therapeutic HIV type 1 immunogen, is intersubtype recombinant.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):357-61. Unique Identifier : AIDSLINE MED/97225063; Choi DJ; Dube S; Spicer TP; Slade HB; Jensen FC; Poiesz BJ; Department of Microbiology, SUNY Health Science Center at Syracuse; 13210, USA.
HIV type 1 subtype F sequences in Romanian children and adults.: AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):363-5. Unique Identifier : AIDSLINE MED/97225064; Apetrei C; Loussert-Ajaka I; Collin G; Letourneur F; Duca M; Saragosti S; Simon F; Brun-Vezinet F; Laboratoire de Virologie, Hopital Bichat-Claude Bernard, Paris,; France.
Reflections on the design and reporting of STD/HIV behavioral intervention research.: AIDS Educ Prev. 1997 Feb;9 Suppl A:1-14. Unique Identifier : AIDSLINE MED/97237117; O'Leary A; DiClemente RJ; Aral SO; Department of Psychology, Rutgers University, New Brunswick, NJ 08903,; USA.
How important is publication bias? A synthesis of available data.: AIDS Educ Prev. 1997 Feb;9 Suppl A:15-21. Unique Identifier : AIDSLINE MED/97237118; Dickersin K; Baltimore Cochrane Center, Department of Epidemiology and Preventive; Medicine, University of Maryland School of Medicine 21201, USA.; kdickers@umabnet.ab.umd.edu; It has long been recognized that investigators frequently fail to report their research findings (Dickersin, 1990). Chalmers (1990) has suggested that this failure represents scientific misconduct since volunteers who consent to participate in research, and agencies that provide funding support for investigations, do
Effects of a skill-based intervention to encourage condom use among high risk heterosexually active adolescents.: AIDS Educ Prev. 1997 Feb;9 Suppl A:22-43. Unique Identifier : AIDSLINE MED/97237119; Gillmore MR; Morrison DM; Richey CA; Balassone ML; Gutierrez L; Farris M; University of Washington, School of Social Work, Seattle 98105-6299,; USA.; OBJECTIVES: In this article we describe the development and testing of three behavioral interventions to reduce the risk of contracting HIV/AIDS and other sexually transmitted diseases among heterosexually active adolescents. METHODS: The interventions include a comic book, a videotape, and a group skill training curr
An impact evaluation of project SNAPP: an AIDS and pregnancy prevention middle school program.: AIDS Educ Prev. 1997 Feb;9 Suppl A:44-61. Unique Identifier : AIDSLINE MED/97237120; Kirby D; Korpi M; Adivi C; Weissman J; ETR Associates, Santa Cruz, California 95061-1830, USA.; OBJECTIVES: A theory-based curriculum designed to delay the onset of intercourse and increase use of condoms was implemented in the classrooms of six Los Angeles middle schools. METHODS: The curriculum activities were very interactive, emphasized skill building, and were implemented by well trained peer educators, inc
Evaluation of the HIV risk reduction intervention for women entering inpatient substance abuse treatment.: AIDS Educ Prev. 1997 Feb;9 Suppl A:62-76. Unique Identifier : AIDSLINE MED/97237121; Eldridge GD; St. Lawrence JS; Little CE; Shelby MC; Brasfield TL; Service JW; Sly K; Community Health Program, Jackson State University, Mississippi 39204,; USA.; OBJECTIVES: Interventions to lower HIV risk behavior among drug users have concentrated on reduction of high risk injection practices. Less attention has been directed to non-injecting drug users and drug-involved women. Female non-injecting drug users e.g., women who abuse alcohol or crack cocaine) are also at substa
Activity and similarity on safe sex workshops led by peer educators.: AIDS Educ Prev. 1997 Feb;9 Suppl A:77-89. Unique Identifier : AIDSLINE MED/97237122; Reeder GD; Pryor JB; Harsh L; Department of Psychology, Illinois State University, Normal 61790,; USA.; OBJECTIVES: Sexually transmitted disease is a growing problem for college students. To address this problem, health professionals on many campuses have turned to peer led prevention workshops. The research evaluated the effectiveness of four types of such workshops. METHODS: The workshops followed either an informatio
Does parental involvement make a difference? The impact of parent interactive activities on students in a school-based AIDS prevention program.: AIDS Educ Prev. 1997 Feb;9 Suppl A:90-106. Unique Identifier : AIDSLINE MED/97237123; Weeks K; Levy SR; Gordon AK; Handler A; Perhats C; Flay BR; Prevention Research Center, University of Illinois at Chicago 60607,; USA.; OBJECTIVES: In this study, we test the effectiveness of involving parents in school-based AIDS education with respect to altering AIDS-related knowledge, attitudes, behavioral intentions, communications patterns, and behavior of students. METHODS: Fifteen high risk school districts (pre-test N = 2,392) were randomly a
Situation of the blood banks in the region of the Americas, 1994-1995.: Epidemiol Bull. 1997 Mar;18(1):11-2. Unique Identifier : AIDSLINE MED/97340595
AIDS surveillance in the Americas.: Epidemiol Bull. 1997 Mar;18(1):16. Unique Identifier : AIDSLINE MED/97340598
Molecular diagnosis of deep nodular bacillary angiomatosis and monitoring of therapeutic success.: Br J Dermatol. 1997 May;136(5):747-51. Unique Identifier : AIDSLINE MED/97349590; Schlupen EM; Schirren CG; Hoegl L; Schaller M; Volkenandt M; Department of Dermatology, Ludwig-Maximilians University, Munich,; Germany.; A 51-year-old human immunodeficiency virus (HIV)-positive male patient (CDC stage 3C) had had a painful nodule on his external ankle joint for 10 months. A biopsy suggested bacillary angiomatosis , but Kaposi s sarcoma could not be excluded. Rods were detectable in lesional sk
Leishmaniasis presenting as a psoriasiform eruption in AIDS [letter]: Br J Dermatol. 1997 May;136(5):792-4. Unique Identifier : AIDSLINE MED/97349602; Rubio FA; Robayna G; Herranz P; Torres E; Pena JM; Contreras F; de Lucas R; Casado M
Human herpesvirus 8 DNA is rarely found in Bowen's disease of non-immunosuppressed patients [letter]: Br J Dermatol. 1997 May;136(5):803-4. Unique Identifier : AIDSLINE MED/97349612; Mitsuishi T; Sata T; Matsukura T; Kawashima M
DNA diploidy in AIDS-related and steroid-induced Kaposi's sarcoma [letter; comment]: Br J Dermatol. 1997 May;136(5):804. Unique Identifier : AIDSLINE MED/97349613; Simonart T; Noel JC; Van Vooren JP; Parent D; Baghli B; Querton G; Verhest A
AIDS therapy: hype or reality? [news]: Ann Oncol. 1996 Sep;7(7):652. Unique Identifier : AIDSLINE MED/97060973
BCL6 can repress transcription from the human immunodeficiency virus type I promoter/enhancer region.: Genes Chromosomes Cancer. 1997 May;19(1):14-21. Unique Identifier : AIDSLINE MED/97281682; Baron BW; Desai M; Baber LJ; Paras L; Zhang Q; Sadhu A; Duguay S; Nucifora G; McKeithan TW; Zeleznik-Le N; Department of Pathology, University of Chicago, Illinois 60637, USA.; The gene BCL6 encodes a zinc finger protein with similarities to transcription factors. We previously reported that a number of viral genomes, including human immunodeficiency virus type I HIV-1), contain sequences which are similar to the BCL6 DNA-binding consensus in their promoter regions. Electrophoretic mobility
A study of HIV seroprevalence in a group of homeless youth in Hollywood, California.: J Adolesc Health. 1997 May;20(5):339-42. Unique Identifier : AIDSLINE MED/97311665; Pfeifer RW; Oliver J; California State University at Long Beach, Department of Social Work,; USA.; The objective of this descriptive-exploratory study was to examine the HIV seroprevalence rate among a sample of homeless youth in Hollywood, California. A total of 96 respondents (age 14-24) were administered a questionnaire and had their blood drawn to test for the presence of HIV antibodies, during nightly street o
A risk profile of street youth in northern California: implications for gender-specific human immunodeficiency virus prevention.: J Adolesc Health. 1997 May;20(5):343-53. Unique Identifier : AIDSLINE MED/97311666; Clements K; Gleghorn A; Garcia D; Katz M; Marx R; San Francisco Department of Public Health, AIDS Office, CA 94102, USA.; PURPOSE: To assess human immunodeficiency virus (HIV) risk behaviors of street youth and to determine whether risk behaviors differ by gender or housing status. METHODS: Using systematic street-based sampling in four Northern California cities, we recruited 429 street youth (mean age = 19.2 years). Participants comple
Health beliefs and intention to get immunized for HIV.: J Adolesc Health. 1997 May;20(5):354-9. Unique Identifier : AIDSLINE MED/97311667; Zimet GD; Liau A; Fortenberry VD; Department of Pediatrics, Indiana University School of Medicine; Indianapolis, USA.; PURPOSE: The purpose of this study was to evaluate the relationship of health beliefs to intention to accept human immunodeficiency virus (HIV) vaccination. METHODS: Respondents were 81 female and 44 male college students who completed self-administered questionnaires. Questionnaires included items assessing intention
Synthesis of an amino acid analogue to incorporate p-aminobenzyl-EDTA in peptides.: Bioconjug Chem. 1997 Mar-Apr;8(2):249-52. Unique Identifier : AIDSLINE MED/97249482; Song AI; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical School,; University of Medicine and Dentistry of New Jersey, Piscataway 08854,; USA.; A convenient and straightforward synthesis of an amino acid analog, [p-(N-alpha-Fmoc-L-aspartic acid-beta-amido)benzyl]-EDTA tetra-tert-butyl ester, compatible with Fmoc solid phase peptide synthesis strategy is described. This reagent was used to incorporate p-aminobenzyl-EDTA at an internal sequence position in an H
Peptomer aluminum oxide nanoparticle conjugates as systemic and mucosal vaccine candidates: synthesis and characterization of a conjugate derived from the C4 domain of HIV-1MN gp120.: Bioconjug Chem. 1997 May-Jun;8(3):424-33. Unique Identifier : AIDSLINE MED/97321119; Frey A; Neutra MR; Robey FA; Department of Pediatrics, Harvard Medical School, Boston,; Massachusetts, USA.; Peptomers are polymers composed of peptides that are specifically cross-linked in a head-to-tail fashion. Recently, a peptomer composed of an amphipathic peptide from the C4 domain of HIV-1MN gp120 was shown to display a prominent alpha-helical conformation that, as an immunogen, elicited rabbit antibodies recognizing
Protection of primary human T cells from HIV infection by Trev: a transdominant fusion gene.: Hum Gene Ther. 1997 May 1;8(7):861-8. Unique Identifier : AIDSLINE MED/97288989; Chinen J; Aguilar-Cordova E; Ng-Tang D; Lewis DE; Belmont JW; Department of Microbiology and Immunology, Baylor College of Medicine,; Houston, TX 77030, USA.; Gene therapy is one of several approaches that are being tested in the search for an effective anti-human immunodeficiency virus HIV) treatment. In this strategy, a protective gene would be introduced into target cells, rendering them relatively resistance to the virus-induced cytopathicity. Tat and Rev are viral pr
Clinical management of syncope and seizures in GUM clinics [editorial]: Int J STD AIDS. 1997 Apr;8(4):211-5. Unique Identifier : AIDSLINE MED/97292641; el-Gadi SM; Richens A
Update on contraception.: Int J STD AIDS. 1997 Apr;8(4):216-22; quiz 223. Unique Identifier : AIDSLINE MED/97292642; Wilkinson CL; Stirland AM; Massil H; Women's and Children's Services, King's College Hospital, Denmark; Hill, London.
Syphilis in injecting drug users: clues for high-risk sexual behaviour in female IDUs.: Int J STD AIDS. 1997 Apr;8(4):225-8. Unique Identifier : AIDSLINE MED/97292643; Muga R; Roca J; Tor J; Pigem C; Rodriguez R; Egea JM; Vlahov D; Munoz A; Infectious Diseases Unit, Hospital Universitario Germans Trias i; Pujol, Badalona, Spain.; The objective was to measure the gender-specific differences for syphilis and for the sexual transmission of human immunodeficiency virus (HIV) in a cross-sectional analysis of injecting drug users (IDUs) admitted to detoxification between February 1987 and January 1990. HIV was determined by enzyme-linked immunosorbe
Determination of factors associated with condom use among women infected with human immunodeficiency virus.: Int J STD AIDS. 1997 Apr;8(4):229-33. Unique Identifier : AIDSLINE MED/97292644; Clark RA; Kissinger P; Bedimo AL; Dunn P; Albertin H; HIV Outpatient Program, Medical Center of Louisiana, New Orleans, USA.; To better understand potential barriers to condom use and the sexual behaviour of women infected with human immunodeficiency virus (HIV), an anonymous self-administered survey was performed on a convenience sample of 83 predominantly single HIV+ women. Most women had only one sexual partner who usually knew of the sub
Hospital and hospice resource use of HIV-positive patients in Edinburgh.: Int J STD AIDS. 1997 Apr;8(4):234-42. Unique Identifier : AIDSLINE MED/97292645; Brettle RP; Atkinson FI; Wilcock J; Richardson A; Lewis R; MacCullum L; Bath G; Regional Infectious Disease Unit, City Hospital, Edinburgh, UK.; A prospective study of health service and hospice resource utilization (average length of stay or ALOS, discharge rate, bed day use, outpatient consultation) analysed with reference to gender, risk activity, immunological and clinical staging (1987 definition of AIDS) for the financial year 1992-93 was undertaken at t
Condom and nonoxynol-9 use and the incidence of HIV infection in serodiscordant couples in Zambia.: Int J STD AIDS. 1997 Apr;8(4):243-50. Unique Identifier : AIDSLINE MED/97292646; Hira SK; Feldblum PJ; Kamanga J; Mukelabai G; Weir SS; Thomas JC; University Teaching Hospital, Lusaka, Zambia.; We aimed to measure the effectiveness of latex condoms and of nonoxynol-9 [N-9] spermicides, in preventing HIV transmission in heterosexual serodiscordant couples in Lusaka. Each couple was examined at clinic visits scheduled at 3-month intervals for one year or more per couple, or until seroconversion or discontinuat
Psychological stress and depression in older patients with intravenous drug use and human immunodeficiency virus infection: implications for intervention.: Int J STD AIDS. 1997 Apr;8(4):251-5. Unique Identifier : AIDSLINE MED/97292647; Singh N; Squier C; Sivek C; Wagener MM; Yu VL; VA Medical Center, Infectious Disease Section, Pittsburgh, PA 15240,; USA.; We aim to assess the age-related differences in psychological stress and depression in patients with human immunodeficiency virus (HIV) infection. Prospective, longitudinal, observational study of patients with HIV followed at a university affiliated VA Medical Center. Fifty-six consecutive patients with HIV infection
Application of 'Clearview Chlamydia' for the rapid detection of cervical chlamydial antigen.: Int J STD AIDS. 1997 Apr;8(4):257-8. Unique Identifier : AIDSLINE MED/97292648; Woolley PD; Pumphrey J; Department of Genitourinary Medicine, University Hospital of South; Manchester, UK.; In a study to evaluate the Clearview chlamydia test in a genitourinary medicine clinic, the sensitivity and specificity were 76.4% and 99.4% respectively when compared with the DAKO IDEIA chlamydia test processed in a department of medical microbiology. The time taken to perform and read the Clearview chlamydia test
Prevalence of Mycoplasma genitalium in asymptomatic men in Japan.: Int J STD AIDS. 1997 Apr;8(4):259-60. Unique Identifier : AIDSLINE MED/97292649; Uno M; Deguchi T; Saito A; Yasuda M; Komeda H; Kawada Y; Department of Urology, Gifu University School of Medicine, Gifu City,; Japan.; We aim to clarify the prevalence of Mycoplasma genitalium in asymptomatic men in Japan . First-catch urine specimens were obtained from 187 asymptomatic Japanese men and examined for the presence of M. genitalium using a polymerase chain reaction PCR)-based assay. Two (1.1%) of 187 f
Infection with HIV, syphilis and hepatitis B in Ethiopia: a survey in blood donors.: Int J STD AIDS. 1997 Apr;8(4):261-4. Unique Identifier : AIDSLINE MED/97292650; Rahlenbeck SI; Yohannes G; Molla K; Reifen R; Assefa A; Department of Microbiology, Gondar College of Medical Sciences,; Ethiopia.; Sera of all male donors appearing at the blood bank of a regional hospital in Northwest Ethiopia in 1994 (n = 1022) and 1995 (n = 1164), were screened for the presence of human immunodeficiency virus (HIV-1) and treponemal antibodies. Additionally, screening for hepatitis B surfa
The judicial response to HIV/AIDS.: Int J STD AIDS. 1997 Apr;8(4):265-71. Unique Identifier : AIDSLINE MED/97292651; Kirby M; High Court of Australia, Canberra, ACT, Australia.
The management of acute myeloid leukaemia (AML) in human immunodeficiency virus (HIV) infection: a case report and review.: Int J STD AIDS. 1997 Apr;8(4):272-4. Unique Identifier : AIDSLINE MED/97292652; Kane D; Keating S; McCann S; Mulcahy F; Department of Genito-Urinary Medicine, St James's Hospital, Dublin,; Ireland.
Rapidly progressive syphilis in early HIV infection.: Int J STD AIDS. 1997 Apr;8(4):275-7. Unique Identifier : AIDSLINE MED/97292653; O'Mahony C; Rodgers CA; Mendelsohn SS; Sissons G; McKay A; Devine J; Keeping IM; Department of Genito-Urinary Medicine, Countess of Chester Hospital,; Chester UK.
Inoculation of culture plates: straightforward or is it?: Int J STD AIDS. 1997 Apr;8(4):278-9. Unique Identifier : AIDSLINE MED/97292654; Carlin EM; Hammond JA; Boag FC; John Hunter Clinic, Chelsea, UK.; In view of the recent vogue in some genitourinary medicine (GUM) units towards selective microscopy we aimed to assess the adequacy of culture plate inoculation in our own GUM clinic by the visual examination of 350 consecutively inoculated plates. Seventy-five (21%) plates were inoculated so lightly that no indentati
Rapid rise in HIV prevalence among women attending government STD clinic in Mumbai (Bombay), India [letter]: Int J STD AIDS. 1997 Apr;8(4):280. Unique Identifier : AIDSLINE MED/97292655; Salunke S; Jagtap MR; Hira S; Dalal P; Jagavkar C
Recombinant human granulocyte colony-stimulating factor increases circulating CD34-postive cells in patients with AIDS.: Ann Hematol. 1997 May;74(5):215-20. Unique Identifier : AIDSLINE MED/97344611; Nielsen SD; Dam-Larsen S; Nielsen C; Wantzia P; Mathiesen L; Hansen JE; Department of Infectious Diseases, Hvidovre Hospital, Denmark.; In a gene therapy-based treatment of AIDS, it would be desirable to have as many transduced target cells as possible. A limiting factor is the number of target cells. In this study, we investigated whether it was possible to increase the absolute number of one possible target cell, i.e., the circulating hematopoietic
Salmonella parotitis with abscess formation in a patient with human immunodeficiency virus infection.: Clin Infect Dis. 1997 May;24(5):1009-10. Unique Identifier : AIDSLINE MED/97287687; Knee TS; Ohl CA; Department of Internal Medicine, National Naval Medical Center,; Bethesda, Maryland, USA.
Brucella melitensis osteitis following craniotomy in a patient with AIDS.: Clin Infect Dis. 1997 May;24(5):1012. Unique Identifier : AIDSLINE MED/97287689; Galle C; Struelens M; Liesnard C; Godfroid J; Maes N; Dewitte O; Farber CM; Clevenbergh P; Van Vooren JP; Departement de Microbiologie, Hopital Erasme, Brussels, Belgium.
Resolution of intractable molluscum contagiosum in a human immunodeficiency virus-infected patient after institution of antiretroviral therapy with ritonavir.: Clin Infect Dis. 1997 May;24(5):1023-5. Unique Identifier : AIDSLINE MED/97287698; Hicks CB; Myers SA; Giner J; Department of Medicine, Duke University Medical Center, Durham, North; Carolina 27710, USA.
Penicillium marneffei infection associated with AIDS [letter; comment]: Clin Infect Dis. 1997 May;24(5):1026. Unique Identifier : AIDSLINE MED/97287700; Dupouy-Camet J; Ancelle T
Tuberculosis and human T-cell lymphotropic virus type 1 infection [letter; comment]: Clin Infect Dis. 1997 May;24(5):1026. Unique Identifier : AIDSLINE MED/97287699; Seaton RA
Human immunodeficiency virus as an infectious cause of pharyngitis [letter; comment]: Clin Infect Dis. 1997 May;24(5):1027. Unique Identifier : AIDSLINE MED/97287701; Gleckman R
An approach to the validation of markers for use in AIDS clinical trials.: Clin Infect Dis. 1997 May;24(5):764-74. Unique Identifier : AIDSLINE MED/97287639; Mildvan D; Landay A; De Gruttola V; Machado SG; Kagan J; Beth Israel Medical Center, New York, New York 10003, USA.; Dr. Mildvan and coauthors have thoroughly reviewed and documented what is known about the validation of surrogate markers for use in clinical trials. They have proposed a classification system based on the usefulness of available immunologic and virological assays as measures of prognosis, drug activity, and therapeut
Antifungal susceptibility testing: technical advances and potential clinical applications[see comments]: Clin Infect Dis. 1997 May;24(5):776-84. Unique Identifier : AIDSLINE MED/97287641; Pfaller MA; Rex JH; Rinaldi MG; Department of Pathology, University of Iowa College of Medicine, Iowa; City 52242, USA.; The clinical application of in vitro antifungal susceptibility testing has been limited by a lack of reproducibility and uncertain clinical relevance. As a result of several collaborative studies, the National Committee for Clinical Laboratory Standards (NCCLS) has proposed a standardized antifungal susceptibility tes
Cytomegalovirus (CMV) viremia and the CD4+ lymphocyte count as predictors of CMV disease in patients infected with human immunodeficiency virus [see comments]: Clin Infect Dis. 1997 May;24(5):836-40. Unique Identifier : AIDSLINE MED/97287650; Gerard L; Leport C; Flandre P; Houhou N; Salmon-Ceron D; Pepin JM; Mandet C; Brun-Vezinet F; Vilde JL; Department of Infectious and Tropical Diseases, Hopital Bichat-Claude; Bernard, Paris, France.; We screened 192 patients infected with human immunodeficiency virus (HIV) to examine the relation between CD4+ lymphocyte counts and cytomegalovirus ( CMV ) viremia and the occurrence of CMV disease and subsequent duration of s
A 5-year retrospective review of adverse drug reactions and their risk factors in human immunodeficiency virus-infected patients who were receiving intravenous pentamidine therapy for Pneumocystis carinii pneumonia.: Clin Infect Dis. 1997 May;24(5):854-9. Unique Identifier : AIDSLINE MED/97287654; O'Brien JG; Dong BJ; Coleman RL; Gee L; Balano KB; University of California San Francisco, Department of Medicine, San; Francisco General Hospital, USA.; The incidence and severity of adverse drug reactions (ADRs) in human immunodeficiency virus-infected persons receiving intravenous pentamidine for Pneumocystis carinii pneumonia during a 5-year period were reviewed retrospectively. Predisposing risk factors for ADRs were identified. ADRs were included if they occurred
Rapid detection of cytomegalovirus in bronchoalveolar lavage fluid and serum samples by polymerase chain reaction: correlation of virus isolation and clinical outcome for patients with human immunodeficiency virus infection.: Clin Infect Dis. 1997 May;24(5):878-83. Unique Identifier : AIDSLINE MED/97287658; Hansen KK; Vestbo J; Benfield T; Lundgren JD; Mathiesen LR; Department of Infectious Diseases, Hvidovre Hospital, Copenhagen,; Denmark.; Bronchoalveolar lavage (BAL) fluids and serum samples from 153 patients with pulmonary symptoms who were infected with human immunodeficiency virus (HIV) and underwent BAL were examined for the presence of cytomegalovirus ( CMV
Etiology of solitary pulmonary nodules in patients with human immunodeficiency virus infection.: Clin Infect Dis. 1997 May;24(5):908-13. Unique Identifier : AIDSLINE MED/97287663; Martinez-Marcos FJ; Viciana P; Canas E; Martin-Juan J; Moreno I; Pachon J; Unit of Infectious Diseases, Hospital Universitario Virgen del Rocio,; Seville, Spain.; We assessed 10 patients with human immunodeficiency virus (HIV) infection (nine of whom had AIDS) and solitary pulmonary nodules SPNs) that were detected on roentgenograms. Five of the patients presented with respiratory symptoms. The etiology of the SPN was determined for eight of these patients: six had infections h
Prevalence of and risk factors for Clostridium difficile colonization at admission to an infectious diseases ward.: Clin Infect Dis. 1997 May;24(5):920-4. Unique Identifier : AIDSLINE MED/97287665; Hutin Y; Casin I; Lesprit P; Welker Y; Decazes JM; Lagrange P; Modai J; Molina JM; Department of Infectious Diseases, Hopital Saint-Louis, Paris, France.; A study of 240 consecutive admissions to a single hospital ward over a 6-month period was conducted to determine the prevalence of and risk factors for Clostridium difficile colonization at admission. The prevalence rate of C. difficile colonization at admission was 13.3%. Seventy-four percent of the patients admitted
Rapid disease progression in human immunodeficiency virus type 1-infected individuals with adverse reactions to trimethoprim-sulfamethoxazole prophylaxis.: Clin Infect Dis. 1997 May;24(5):936-41. Unique Identifier : AIDSLINE MED/97287668; Veenstra J; Veugelers PJ; Keet IP; van der Ven AJ; Miedema F; Lange JM; Coutinho RA; Municipal Health Service, Department of Public Health, Nijmegen, The; Netherlands.; We studied the relation between the occurrence of adverse reactions to trimethoprim-sulfamethoxazole (TMP-SMZ) prophylaxis and the subsequent course of human immunodeficiency virus (HIV) infection in a cohort of homosexual men. Adverse reactions to TMP-SMZ were associated with a more rapid progression to AIDS (P
Markedly elevated serum lactate dehydrogenase levels are a clue to the diagnosis of disseminated histoplasmosis in patients with AIDS.: Clin Infect Dis. 1997 May;24(5):942-4. Unique Identifier : AIDSLINE MED/97287669; Corcoran GR; Al-Abdely H; Flanders CD; Geimer J; Patterson TF; Department of Medicine, The University of Texas Health Science Center; at San Antonio, 78284-7881, USA.; Disseminated histoplasmosis is a common late manifestation of AIDS, but the diagnosis may be unsuspected in some patients because the clinical presentation of histoplasmosis may mimic other opportunistic infections. High serum lactate dehydrogenase LDH) levels have been associated with disseminated histoplasmosis. We
Relationship of adverse events to serum drug levels in patients receiving high-dose azithromycin for mycobacterial lung disease.: Clin Infect Dis. 1997 May;24(5):958-64. Unique Identifier : AIDSLINE MED/97287673; Brown BA; Griffith DE; Girard W; Levin J; Wallace RJ Jr; Department of Microbiology, The University of Texas Health Center at; Tyler, 75710, USA.; We treated 39 elderly human immunodeficiency virus-noninfected patients with Mycobacterium avium complex and/or Mycobacterium abscessus lung disease with azithromycin (600 mg daily), given initially as monotherapy. Adverse events occurred in 33 of 39 patients (85%) receiving azithromycin alone, most commonly gastroint
Acute human immunodeficiency virus type 1 disease as a mononucleosis-like illness: is the diagnosis too restrictive?: Clin Infect Dis. 1997 May;24(5):965-70. Unique Identifier : AIDSLINE MED/97287674; Vanhems P; Allard R; Cooper DA; Perrin L; Vizzard J; Hirschel B; Kinloch-de Loes S; Carr A; Lambert J; Hotel-Dieu de Montreal, and Departement de Medecine Sociale et; Preventive, Universite de Montreal, Quebec, Canada.; The purpose of this study was to describe the frequency and duration of clinical features at the time of acute human immunodeficiency virus type 1 (HIV-1) disease in 218 patients with documented symptomatic primary HIV-1 infection. The mean duration of acute HIV-1 disease was 25.1 days (median, 20.0 days) and did not
The clinical course of human immunodeficiency virus infection in genetically identical children [see comments]: Clin Infect Dis. 1997 May;24(5):971-4. Unique Identifier : AIDSLINE MED/97287675; Saulsbury FT; Department of Pediatrics, University of Virginia Health Sciences; Center, Charlottesville 22908, USA.; Human immunodeficiency virus (HIV) infection in children is associated with diverse clinical manifestations and highly variable rates of progression. There is little information concerning the clinical course of HIV infection in genetically identical children. We review the cases of identical triplets who were infecte
Progression of human immunodeficiency virus infection in children is related to the interaction of the virus, the immune system, and then some [editorial; comment]: Clin Infect Dis. 1997 May;24(5):975-6. Unique Identifier : AIDSLINE MED/97287676; Pizzo PA
CD4 cell counts in human immunodeficiency virus-negative patients with tuberculosis.: Clin Infect Dis. 1997 May;24(5):988-91. Unique Identifier : AIDSLINE MED/97287680; Jones BE; Oo MM; Taikwel EK; Qian D; Kumar A; Maslow ER; Barnes PF; Department of Medicine, University of Southern California School of; Medicine, Los Angeles 90033, USA.; We evaluated 85 human immunodeficiency virus (HIV)-negative patients with tuberculosis for clinical features and CD4 cell counts. Thirty-seven patients had low CD4 cell counts (mean +/- SD, 341 +/- 116 cells/microL), and 48 patients had normal CD4 cell counts (mean +/- SD, 830 +/- 254 cells/microL). CD4 cell counts we
Lymphotoxin-beta and TNF regulation in T cell subsets: differential effects of PGE2.: Cytokine. 1997 Mar;9(3):157-65. Unique Identifier : AIDSLINE MED/97271794; Ferreri NR; Millet I; Askari B; Magnani P; Ruddle NH; Department of Pharmacology, New York Medical College, Valhalla, USA.; The effects of prostaglandin E2 (PGE2) on lymphotoxin beta LT-beta) and tumour necrosis factor alpha (TNF) were assessed in murine CD4+ Th1 and Th2 T cell clones. LT-beta mRNA was constitutively expressed by both T cell subsets. However, PGE2 inhibited its accumulation only in Th1, but not Th2 clones. PGE2 inhibited T
The production of soluble interleukin 4 receptors is preferentially regulated by the murine Th2 cell subset.: Cytokine. 1997 Mar;9(3):166-77. Unique Identifier : AIDSLINE MED/97271795; Fernandez-Botran R; Chilton PM; Ma Y; Windsor JL; Street NE; Division of Immunology and Immunopathology, School of Medicine,; University of Louisville, KY 40292, USA.; In order to understand how the endogenous production of soluble IL-4 receptors (sIL-4r) is regulated, the authors tested prototypic clones of Th1 and Th2 murine CD4+ T cell subsets for their ability to regulate their expression of sIL-4r. Results showed that although both types of clones produced low levels of sIL-4r
Identification of an HLA-DQ6-derived peptide recognized by mouse MHC class I H-2Db-restricted CD8+ T cells in HLA-DQ6 transgenic mice.: Jpn J Hum Genet. 1997 Mar;42(1):225-32. Unique Identifier : AIDSLINE MED/97327250; Takeshita T; Fukui Y; Yamamoto K; Yamane K; Inamitsu T; Kamikawaji N; Sasazuki T; Department of Genetics, Kyushu University, Fukuoka, Japan.; CD8+ T cells from C57BL/6(B6) mice show cytotoxicity to B cell blasts prepared from syngeneic transgenic mice expressing HLA-DQ6 molecules in a mouse MHC class I H-2Db restricted manner. Although these results suggest that CD8+ T cells recognize peptides derived from DQ6 molecule bound to H-2Db on target cells, no dir
[Effect of acupuncture on immunomodulation in patients with malignant tumors]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1996 Mar;16(3):139-41. Unique Identifier : AIDSLINE MED/97352253; Wu B; Zhou RX; Zhou MS; First Affiliated Hospital, West China University of Medical Sciences,; Chengdu.; In order to investigate the role of acupuncture in the regulation of cellular immune function, the changes of T lymphocyte subsets CD3+, CD4+, CD8+), soluble interleukin-2 receptor (SIL-2 R) and beta-endorphine (beta-EP) in the peripheral blood of patients with malignant tumors before and after acupuncture were observ
[Mechanism of the treatment of pigmentary degeneration of retina with traditional Chinese medicine]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1996 Mar;16(3):176-8. Unique Identifier : AIDSLINE MED/97352262; Wu XW; Tang YZ
[The immunological aspects in the HIV/AIDS-tuberculosis association in children]: Pneumoftiziologia. 1996 Jul-Dec;45(3-4):149-53. Unique Identifier : AIDSLINE MED/97312143; Murgoci G; Banica D; Anastasatu O; Institutul de Pneumoftiziologie Marius Nasta, Bucuresti.; HIV-infected subjects are submitted to various immunity disorders, the function of immune competent cells disturbing, the most important one, resulting in severe opportunistic infections. The progressive depletion of CD4 subset of lymphocytes in HIV-infected persons is the most significant one. When HIV infection is a
[Perinatal HIV transmission. The mechanisms and preventive measures]: Pneumoftiziologia. 1996 Jul-Dec;45(3-4):155-64. Unique Identifier : AIDSLINE MED/97312144; Delfraissy JF; Hopital K. Bicetre, Kremlin Bicetre.
Sexual health--a Health of the Nation failure [see comments]: BMJ. 1997 Jun 14;314(7096):1743-7. Unique Identifier : AIDSLINE MED/97346087; Adler MW; Department of Sexually Transmitted Diseases, University College London; Medical School.
HIV and AIDS, other sexually transmitted diseases, and tuberculosis in ethnic minorities in United Kingdom: is surveillance serving its purpose? [see comments]: BMJ. 1997 Jun 14;314(7096):1747-51. Unique Identifier : AIDSLINE MED/97346088; De Cock KM; Low N; London School of Hygiene and Tropical Medicine.; Experience of disease differs across ethnic groups, and ethnicity is a relevant personal characteristic for descriptive epidemiology. Information about ethnicity and country of birth is omitted from the routine notification of many diseases. HIV infection and AIDS, other sexually transmitted diseases, and tuberculosis
Deaths related to methadone have doubled in Lothian [letter]: BMJ. 1997 Jun 14;314(7096):1763. Unique Identifier : AIDSLINE MED/97346102; Greenwood J; Zealley H; Gorman D; Fineron P; Squires T
Designing and evaluating strategies to recruit African Americans for AIDS/HIV interventions: targeting the African-American family.: Ethn Dis. 1996 Autumn;6(3-4):301-10. Unique Identifier : AIDSLINE MED/97240860; Icard LD; Zamora-Hernandez CE; Spencer MS; Catalano R; University of Washington, School of Social Work, Seattle, USA.; icardl@u.washington.edu; The successful recruitment of African-Americans for AIDS/HIV interventions is essential to reducing HIV transmission and the spread of AIDS among this population. However, many high risk groups in the African-American community are reluctant to participate in AIDS/HIV interventions due to factors such as poverty, and
New perspectives in clinical practice. Introduction.: Bull Menninger Clin. 1997 Spring;61(2):143-5. Unique Identifier : AIDSLINE MED/97293492; Menninger WW; Menninger Clinic, USA.
The evolution of adjustment issues in HIV/AIDS.: Bull Menninger Clin. 1997 Spring;61(2):146-88. Unique Identifier : AIDSLINE MED/97293493; Kobayashi JS; University of Colorado Health Sciences Center in Denver, USA.; The issues of emotional adjustment to AIDS have been inextricably linked to medical advances in fundamental knowledge about the human immunodeficiency virus and its potential therapies. In 1987 patients were struggling with the advantages and disadvantages to do or not to do
Results from the 1995 survey of prevalent clinically diagnosed HIV infection in England, Wales, and Northern Ireland.: Commun Dis Rep CDR Rev. 1997 May 30;7(6):R77-82. Unique Identifier : AIDSLINE MED/97328879; Molesworth AM; PHLS AIDS Centre, Communicable Disease Surveillance Centre, London.; amoleswo@phls.co.uk; Health districts in England, Wales, and Northern Ireland were surveyed in 1996 to collect summary information about people with diagnosed HIV infection who received care under the statutory services in 1995. The survey provided demo
Antisignature oligonucleotides and their analogs as inhibitors of mollicutes-cofactors of HIV.: Mikrobiol Z. 1997 Mar-Apr;59(2):3-11. Unique Identifier : AIDSLINE MED/97320836; Skrypal' IH; Babychev VV; Panchenko LP; Iehorov OV; Korobkova KS; Dubei IIa; Fedoriak DM; Shalamai AS; Institute of Microbiology and Virology, Kyiv, Ukraine.; Inhibition of mollicutes by synthetic oligonucleotides and their analogs complementary to specific signature regions of 16S rRNA and corresponding sequences of ribosomal operon DNA was studied. It was shown that antisignature oligonucleotides inhibited transcription in vitro for above 79% interacting specifically wi
A family's right to know?: Camb Q Healthc Ethics. 1997 Winter;6(1):93-9. Unique Identifier : AIDSLINE MED/97266173; Simon S; Hartz JN; Micco G
Contribution of a liaison clinical pharmacist to an inpatient palliative care unit.: Palliat Med. 1997 May;11(3):209-16. Unique Identifier : AIDSLINE MED/97349733; Lucas C; Glare PA; Sykes JV; HIV/AIDS Unit, Royal Prince Alfred Hospital, Sydney, Australia.; The impact on patient care of interventions made by a liaison clinical pharmacist visiting a busy inpatient palliative care unit were evaluated using a validated six-point scoring system. Interventions made in 13% of patients could improve patient care, save money or both, but rarely involved the drugs that are common
Cholecystectomy and AIDS [letter; comment]: J Am Coll Surg. 1997 Jun;184(6):669-70. Unique Identifier : AIDSLINE MED/97322638; Flum DR; Wallack MK
Yield of computed tomography and bronchoscopy for the diagnosis of Mycobacterium avium complex pulmonary disease.: Am J Respir Crit Care Med. 1997 Jun;155(6):2041-6. Unique Identifier : AIDSLINE MED/97339514; Tanaka E; Amitani R; Niimi A; Suzuki K; Murayama T; Kuze F; Department of Infection and Inflammation, Chest Disease Research; Institute, Kyoto University, Sakyo-ku, Japan.; Mycobacterium avium complex (MAC) pulmonary disease with nodules and bronchiectasis is increasing. But the usefulness of computed tomography (CT) and bronchoscopy for diagnosis and the significance of MAC isolation from respiratory secretions are still unclear. For a 4-yr period, we prospectively examined the role of
[Approval of the list of organizations, enterprises, works and their structural divisions whose activities grant the right to fix an extra 20% payment (wage rate) for diagnosing and treating HIV-infected persons and also for work connected with HIV-containing specimens]: Klin Lab Diagn. 1997 Apr;(4):49-50. Unique Identifier : AIDSLINE MED/97323813
[Working hours and vacations of specialists dealing with the diagnosis and treatment of HIV-infected persons and those working with HIV-containing specimens]: Klin Lab Diagn. 1997 Apr;(4):50-1. Unique Identifier : AIDSLINE MED/97323814
Introduction to Wolf Creek IV Conference.: New Horiz. 1997 May;5(2):97-105. Unique Identifier : AIDSLINE MED/97297569; Safar P; University of Pittsburgh Medical Center, PA.; Early milestones of resuscitation research culminated in the 1950s in the documentation of modern external cardiovascular resuscitation (CPR) steps ABC, followed by advanced and prolonged life support. Implementation of guidelines has been suboptimal. Self-training of the public in life-supporting first aid, includi
Picture story. HIV-1 fusion core.: Nat Struct Biol. 1997 Jun;4(6):442. Unique Identifier : AIDSLINE MED/97331318
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.: Nat Struct Biol. 1997 Jun;4(6):490-7. Unique Identifier : AIDSLINE MED/97331326; Achari A; Somers DO; Champness JN; Bryant PK; Rosemond J; Stammers DK; Glaxo Wellcome Research & Development, Beckenham, Kent, UK.; aa37795@ggr.co.uk; Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide as the active component of the dye Prontosil rubrum led to the synthesis of clinically useful analogues. Today sulfamethoxazole (in combination with trimethoprim), is used to treat urinary t
Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein.: J Interferon Cytokine Res. 1997 May;17(5):287-93. Unique Identifier : AIDSLINE MED/97325414; Babe LM; Unal A; Craik CS; Department of Pharmaceutical Chemistry, University of California, San; Francisco, USA.; The effect of human interferon-alpha (Hu-IFN-alpha) on the maturation process of the human immunodeficiency virus type 1 HIV-1) has been studied using stable cell lines that produce nonenveloped particles. These cell lines secrete particles devoid of the viral envelope proteins gp120 and gp41. The CH-1 cells produce a
Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors.: Cancer Res. 1997 Jun 15;57(12):2341-5. Unique Identifier : AIDSLINE MED/97336009; Wagner CR; Ballato G; Akanni AO; McIntee EJ; Larson RS; Chang S; Abul-Hajj YJ; Department of Medicinal Chemistry, Graduate Program in Microbial; Engineering, University of Minnesota, Minneapolis 55455, USA.; wagne003@maroon.tc.umn.edu; Originally designed as an antitumor agent, zidovudine ( AZT ) has exhibited only marginal tumor growth inhibitory activity. Recently, three abstracts have described positive clinical outcomes for a small number of patients with advanced breast cancer tr
Trioma-based vaccination against B-cell lymphoma confers long-lasting tumor immunity.: Cancer Res. 1997 Jun 15;57(12):2346-9. Unique Identifier : AIDSLINE MED/97336010; Mocikat R; Selmayr M; Thierfelder S; Lindhofer H; GSF-Institut fur Immunologie, Munchen, Germany. mocikat@gsf.de; A major goal of tumor immunotherapy is the induction of a systemic immune response against tumor antigens such as the tumor-specific immunoglobulin idiotype (Id) expressed by lymphomas of the B-cell lineage. We describe an approach based on specific redirection of the tumor Id toward professional antigen-presenting ce
The gay adolescent: stressors, adaptations, and psychosocial interventions.: Clin Psychol Rev. 1997;17(2):191-216. Unique Identifier : AIDSLINE MED/97285461; Radkowsky M; Siegel LJ; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY; 10461, USA.; Social stigmatization hinders the ability of gay adolescents to achieve the tasks of adolescence. Because their sexual identity is denigrated by society, these youth have difficulty forming a positive identity and establishing healthy peer and intimate relationships. Family relations are often painful, and gay adolesc
Brain atrophy in HIV infection is more strongly associated with CDC clinical stage than with cognitive impairment.: J Int Neuropsychol Soc. 1997 May;3(3):276-87. Unique Identifier : AIDSLINE MED/97304756; Di Sclafani V; Mackay RD; Meyerhoff DJ; Norman D; Weiner MW; Fein G; Department of Psychiatry, University of California, San Francisco; 94121, USA.; HIV infection often results in MRI-detectable brain atrophy and white matter signal hyperintensities (WMSHs). Magnetic resonance images were obtained from 31 HIV+ male patients and 10 high-risk controls. Variation within the HIV+ group on neuropsychological NP) impairment and stage of systemic disease were relatively
Penicillin-resistant pneumococci in adult disease with special reference to AIDS patients.: Microb Drug Resist. 1995 Spring;1(1):9-28. Unique Identifier : AIDSLINE MED/97301360; Bouza E; Munoz P; Servicio de Microbiologia Clinica y Enfermedades Infecciosas-HIV,; Hospital General Universitario Gregorio Maranon, Madrid, Spain.
A new human herpesvirus as a factor in the pathogenesis of Kaposi's sarcoma and body-cavity lymphoma [comment]: Cancer J Sci Am. 1997 May-Jun;3(3):140-1. Unique Identifier : AIDSLINE MED/97305519; Sarris A; Department of Hematology, M.D. Anderson Cancer Center, Houston, Texas; 77030-4009, USA.
Kaposi's-sarcoma-associated herpesvirus is detected in peripheral blood mononuclear cells of HIV-infected homosexuals more often than in heterosexuals [see comments]: Cancer J Sci Am. 1997 May-Jun;3(3):153-6. Unique Identifier : AIDSLINE MED/97305522; Rizzieri DA; Liu J; Miralles D; Traweek ST; Department of Medicine, Duke University Medical Center, Durham, North; Carolina 27710, USA.; PURPOSE: The Kaposi s-sarcoma-associated herpesvirus is thought likely to play an important part in the pathogenesis of Kaposi s sarcoma, which is the most common tumor in AIDS patients. To determine whether peripheral blood is also infected by the virus, we prospectively tested mononuclear cells from HIV-infected ind
Suppression of enveloped virus production with a substance from silkworm faeces.: Cell Struct Funct. 1996 Dec;21(6):501-14. Unique Identifier : AIDSLINE MED/97233409; Hiraki A; Ikuno Y; Kim J; Ueda S; Institute of Molecular and Cellular Biology for Pharmaceutical; Science, Kyoto Pharmaceutical University, Japan.; In the course of investigating effective biological active substances, we detected a substance in an extract of silkworm faeces that markedly suppresses viral production. The extract, prepared with hot phosphate-buffered saline and purified with ammonium sulfate precipitation, inhibited HVJ (Sendai virus), HSV herpes
Comparative evaluation of different methods for disulfide bond formation in synthesis of the HIV-2 antigenic determinant.: J Pept Res. 1997 Jan;49(1):52-8. Unique Identifier : AIDSLINE MED/97273367; Kudryavtseva EV; Sidorova MV; Ovchinnikov MV; Bespalova ZD; Bushuev VN; Laboratory of Peptide Synthesis, Russian Academy of Medical Sciences,; Moscow, Russia.; The peptide H-Asn-Ser-Trp-Gly-Cys-Ala-Phe-Arg-Gln-Val-Cys-NHEt corresponding to the 593-603 sequence of gp41 protein of the HIV-2 was used to evaluate different methods for the removal of Acm-protection and subsequent disulfide bond formation. The studied methods involved the treatment by salts of heavy metals silver
Communicable diseases surveillance.: Commun Dis Intell. 1997 May 29;21(11):150-9. Unique Identifier : AIDSLINE MED/97331922
HIV/AIDS in the elderly: a hidden population.: Home Care Provid. 1997 Apr;2(2):69-75. Unique Identifier : AIDSLINE MED/97332179; Emlet CA; Solano County Health and Social Services Department, Fairfield,; California 94533, USA.
Non-Hodgkin's lymphoma of the heart in patients infected with human immunodeficiency virus.: Clin Cardiol. 1997 May;20(5):497-502. Unique Identifier : AIDSLINE MED/97279911; Duong M; Dubois C; Buisson M; Eicher JC; Grappin M; Chavanet P; Portier H; Department of Infectious Diseases, Hopital du Bocage, Dijon, France.; A case of HIV-associated cardiac non-Hodgkin s lymphoma (NHL) is described, and the epidemiologic and clinicopathologic features of 21 cases previously reported in the literature are analyzed. All patients were homosexual males, and the cardiac NHL was the first acquired immune def
Sites of tuberculous involvement in patients with AIDS. Autopsy findings and evaluation of gallium imaging.: Clin Nucl Med. 1997 May;22(5):310-4. Unique Identifier : AIDSLINE MED/97297062; Abdel-Dayem HM; Naddaf S; Aziz M; Mina B; Turoglu T; Akisik MF; Omar WS; DiFabrizio L; LaBombardi V; Kempf JS; New York Medical College, Valhalla, USA.; The purpose of this study was to review autopsy and gallium scan findings in two different acquired immune deficiency syndrome AIDS) patient populations who had a confirmed diagnosis of tuberculosis (TB) to identify organs involved and accuracy of clinical diagnosis. The first group was comprised of 29 autopsies betwe
Case report: fulminant Toxoplasma gondii pneumonia in a patient with AIDS.: Clin Radiol. 1997 Jun;52(6):472-4. Unique Identifier : AIDSLINE MED/97346174; Rottenberg GT; Miszkiel K; Shaw P; Miller RF; Department of Imaging, University College London Hospital Trust, UK.
Hospital infection control practices for tuberculosis.: Clin Chest Med. 1997 Mar;18(1):19-33. Unique Identifier : AIDSLINE MED/97253165; Davis YM; McCray E; Simone PM; Surveillance and Epidemiology Branch, Division of Tuberculosis; Elimination, Centers for Disease Control and Prevention, Atlanta,; Georgia, USA.; Although completely eliminating the risk for transmission of M. tuberculosis in all health-care facilities may not be possible, adherence to the principles outlined in the CDC guidelines should reduce the risk to persons in such settings. The guidelines are designed to help health-care facilities develop an infection-
Using therapeutic drug monitoring to dose the antimycobacterial drugs.: Clin Chest Med. 1997 Mar;18(1):79-87. Unique Identifier : AIDSLINE MED/97253169; Peloquin CA; Infectious Disease Pharmacokinetics Laboratory, National Jewish Center; for Immunology and Respiratory Medicine, Denver, Colorado, USA.; The available data suggest that selected patients with tuberculosis and MAC fail to respond to therapy because they malabsorb their medications. In particular, patients with AIDS and known gastrointestinal diseases have problems absorbing these drugs. In addition, because MDR-TB and MAC are so difficult to treat, TDM
Unique aspects of tuberculosis in the pediatric population.: Clin Chest Med. 1997 Mar;18(1):89-98. Unique Identifier : AIDSLINE MED/97253170; Correa AG; Department of Pediatrics, Baylor College of Medicine, Houston, Texas,; USA.; Therapeutic drug monitoring is a process that allows clinicians to quantitate and control drug therapy. Serum concentration data allow for the explicit determination of pharmacokinetic and pharmacodynamic parameters for individual patients. This information assists the clinician in designing treatment regimens that pr
The epidemiology of tuberculosis in the United States.: Clin Chest Med. 1997 Mar;18(1):99-113. Unique Identifier : AIDSLINE MED/97253171; McCray E; Weinbaum CM; Braden CR; Onorato IM; Surveillance and Epidemiology Branch, Division of Tuberculosis; Elimination, Centers for Disease Control and Prevention, Atlanta,; Georgia, USA.; After a dramatic increase in the incidence of TB in the United States from 1985 to 1992, the epidemiology of TB changed, with both the number of cases and the incidence of TB decreasing since 1992. The decreases have been focal, however, affecting only certain geographic areas (e.g., N
Prevalence of axis I disorders in an AIDS cohort: a cross-sectional, controlled study.: Compr Psychiatry. 1997 May-Jun;38(3):146-54. Unique Identifier : AIDSLINE MED/97298968; Rabkin JG; Ferrando SJ; Jacobsberg LB; Fishman B; Department of Psychiatry, Cornell University Medical College, NY, USA.; The primary purpose of this study was to assess the prevalence of major psychiatric disorders in human immunodeficiency virus-positive (HIV+) men with acquired immune deficiency syndrome (AIDS)-defining conditions. Secondary goals were to identify correlates of distress and psychopathology, and to determine whether th
Correlates of change in depressive symptomatology among gay men with AIDS.: Health Psychol. 1997 May;16(3):230-8. Unique Identifier : AIDSLINE MED/97297232; Siegel K; Karus D; Raveis VH; Department of Social Work, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA. siegelk@mskcc.org; Longitudinal data from a sample of gay men living with AIDS (N = 128) were used to assess the relationship of change in various individual and situational correlates with change in depression. Results of regression analyses suggest that changes in physical symptomatology, in the number of bed days, and in the perceive
Coping self-efficacy buffers psychological and physiological disturbances in HIV-infected men following a natural disaster.: Health Psychol. 1997 May;16(3):248-55. Unique Identifier : AIDSLINE MED/97297234; Benight CC; Antoni MH; Kilbourn K; Ironson G; Kumar MA; Fletcher MA; Redwine L; Baum A; Schneiderman N; Department of Psychology, University of Miami, USA.; benight@mail.uccs.edu; The importance of coping self-efficacy (CSE) appraisals on psychological and physiological functioning for HIV seropositive patients facing a severe environmental stressor was tested comparing 37 HIV-infected gay men and 42 healthy male control participants following Hurricane Andrew. Results suggested that greater le
Central venous catheter-related sepsis in a cohort of 366 hospitalised patients.: Eur J Clin Microbiol Infect Dis. 1997 Mar;16(3):203-9. Unique Identifier : AIDSLINE MED/97277971; Tacconelli E; Tumbarello M; Pittiruti M; Leone F; Lucia MB; Cauda R; Ortona L; Department of Infectious Diseases, Universita Cattolica Sacro Cuore,; Rome, Italy.; Five hundred two central venous catheters inserted in 366 patients were evaluated prospectively over a one-year period to determine the frequency and risk factors associated with catheter-related sepsis. For study purposes, in cases in which catheter infection was suspected but the initial blood cultures were negative
Evaluation of the E test for fluconazole susceptibility testing of Candida albicans isolates from oropharyngeal candidiasis.: Eur J Clin Microbiol Infect Dis. 1997 Mar;16(3):228-32. Unique Identifier : AIDSLINE MED/97277975; Dannaoui E; Colin S; Pichot J; Piens MA; Universite Claude Bernard Lyon I, Laboratoire de Parasitologie et; Mycologie Medicale, Lyon, France.; The aim of the present study was to evaluate the utility of the E test in determining the antifungal susceptibility of Candida albicans. Reproducibility of the E test was determined for amphotericin B, fluconazole, and itraconazole using three different solid media: RPMI 1640, Casitone, and yeast nitrogen base agar. M
Acute mediastinitis due to Rhodococcus equi in a patient with human immunodeficiency virus infection.: Eur J Clin Microbiol Infect Dis. 1997 Mar;16(3):241-4. Unique Identifier : AIDSLINE MED/97277978; Casado JL; Antela A; Sanchez JA; Hermida JM; Meseguer M; Infectious Diseases Unit, Hospital Ramon y Cajal, Madrid, Spain.; A patient with human immunodeficiency virus infection developed anterior mediastinitis during antibiotic treatment for empyema due to Rhodococcus equi. This is the first reported case of infection with this organism in this setting. Despite an adequate course of therapy and maintenance treatment with antibiotics to wh
Pleural and peritoneal leishmaniasis in an AIDS patient.: Eur J Clin Microbiol Infect Dis. 1997 Mar;16(3):246-8. Unique Identifier : AIDSLINE MED/97277980; Munoz-Rodriguez FJ; Padro S; Pastor P; Rosa-Re D; Valls ME; Miro JM; Gatell JM; Infectious Diseases Service, Hospital Clinic, Barcelona, Spain.; The case of an AIDS patient who developed pleuritis and peritonitis in the course of relapsing visceral leishmaniasis is reported. Visceral leishmaniasis, considered an opportunistic infection in patients infected with the human immunodeficiency virus (HIV) who live in endemic areas, has a chronic relapsing course. Ty
Significance of indeterminate reactivity to human T-cell lymphotropic virus in western blot analysis of individuals at risk.: Eur J Clin Microbiol Infect Dis. 1997 Mar;16(3):249-52. Unique Identifier : AIDSLINE MED/97277981; Medrano FJ; Soriano V; Calderon EJ; Rey C; Gutierrez M; Bravo R; Leal M; Gonzalez-Lahoz J; Lissen E; Department of Internal Medicine, Virgen del Rocio University Hospital,; Sevilla, Spain.; Current tests to confirm human T-cell lymphotropic virus (HTLV) infection in individuals at risk of retroviral infection commonly yield indeterminate results. To assess the significance of HTLV-seroindeterminate reactivities in a high-risk population, 16 at-risk individuals who had this serologic pattern by Western bl
Sexually transmitted diseases among foreigners in Italy. Migration Medicine Study Group.: Epidemiol Infect. 1997 Jun;118(3):235-41. Unique Identifier : AIDSLINE MED/97351452; Suligoi B; Giuliani M; Istituto Superiore di Sanita, National AIDS Center, Rome, Italy.; A sentinel surveillance system for the control of sexually transmitted diseases (STD) among foreigners was developed in Italy in 1991. From January 1991 to June 1995, 4030 foreigners with a new STD episode were reported. More than one-third of them were North-Africans. The most freq
The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals.: Epidemiol Infect. 1997 Jun;118(3):259-66. Unique Identifier : AIDSLINE MED/97351455; Mocroft A; Johnson MA; Sabin CA; Bofill M; Janossy G; Phillips AN; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.; The relationship, in 539 individuals infected with the human immunodeficiency virus (HIV), between two prognostic markers, the CD4 count and beta-2-microglobulin (B2M), and the development of the acquired immunodeficiency syndrome (AIDS) and death was investigated. Cox proportional hazards models were used to determin
Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse.: Diabetes. 1997 Jul;46(7):1124-32. Unique Identifier : AIDSLINE MED/97344119; Zekzer D; Wong FS; Wen L; Altieri M; Gurlo T; von Grafenstein H; Sherwin RS; Section of Endocrinology, Yale University School of Medicine, New; Haven, Connecticut 06520-8020, USA.; A cloned Th1 cell line was isolated from pancreatic lymph nodes of NOD mice that carries a T-cell receptor encoding Vbeta14 and proliferates in response to NOD islets, islet supernatant, and crystalline bovine and rat insulin, specifically to a B-chain peptide bound to IA(g7). The response to islet supernatant was red
Histology/cytology discrepancies in HIV-infected obstetric patients with normal pap smears.: Gynecol Oncol. 1997 Jun;65(3):430-3. Unique Identifier : AIDSLINE MED/97334273; Robinson WR; Barnes SE; Adams S; Perrin MS; Department of Obstetrics and Gynecology, Tulane University School of; Medicine, New Orleans, Louisiana 70112, USA.; OBJECTIVE: To estimate the frequency of cervical cytologic/histologic discrepancies in a group of obstetric patients diagnosed as HIV infected by routine prenatal screening. Also, to determine if serum CD4 levels or sexually transmitted diseases (STDs) are associated with the occurrence of preinvasive cervical disease
HIV-1 recombinant gp41 induces IL-10 expression and production in peripheral blood monocytes but not in T-lymphocytes.: Immunol Lett. 1997 Feb;55(2):109-13. Unique Identifier : AIDSLINE MED/97289019; Koutsonikolis A; Haraguchi S; Brigino EN; Owens UE; Good RA; Day NK; All Children's Hospital, Department of Pediatrics, University of South; Florida, St. Petersburg 33701, USA.; The effects of recombinant gp41 (rgp41) protein of the human immunodeficiency virus type 1 (HIV-1) on interleukin 10 (IL-10) expression and production using human peripheral blood mononuclear cells was investigated. Expression of IL-10 mRNA was demonstrated within 3 h of cell exposure to endotoxin-free rgp41 by RT-PCR
Structural constraints of HIV-1 Nef may curtail escape from HLA-B7-restricted CTL recognition.: Immunol Lett. 1997 Feb;55(2):119-22. Unique Identifier : AIDSLINE MED/97289021; Bauer M; Lucchiari-Hartz M; Maier R; Haas G; Autran B; Eichmann K; Frank R; Maier B; Meyerhans A; Abteilung Virologie, Universitat Freiburg, Germany.
Baseline HIV type 1 load predicts the long-term clinical outcome of infected patients. The 'positive feedback theory'.: Immunol Lett. 1997 Feb;55(2):123-5. Unique Identifier : AIDSLINE MED/97289022; Briant L; Devaux C; Laboratoire d'Immunologie des Infections Retrovirales, CNRS ERS155,; Montpellier, France.
Class II MHC expression on rat intestinal intraepithelial lymphocytes.: Immunol Lett. 1997 Feb;55(2):63-8. Unique Identifier : AIDSLINE MED/97289012; Kearsey JA; Stadnyk AW; Department of Microbiology and Immunology, Dalhousie University,; Halifax, Nova Scotia, Canada.; The expression of class II major histocompatibility complex (MHC) on rat intestinal intraepithelial lymphocytes (IELs) and mesenteric lymph node cells (MLNCs) were examined by immunofluorescence and flow cytometry. As expected, MLNCs contain eight small populations of CD4+ class II MHC+ T-cells in addition to classica
A polypeptide encoded within the murine AIDS defective virus stimulates primary proliferation of CD8+ T-cells.: Immunol Lett. 1997 Feb;55(2):93-8. Unique Identifier : AIDSLINE MED/97289016; Yee ST; Abe E; Okada Y; Matsuura Y; Takebe Y; Ogasawara K; Takahashi H; Mizuochi T; Department of Bacterial and Blood Products, National Institute of; Health, Tokyo, Japan.; The murine AIDS (MAIDS) is a retrovirus-induced disease that shows severe immunodeficiency with abnormal lymphoproliferation in susceptible strains of mice. To clarify the antigenicity of gag gene products of the LP-BM5 defective virus, which is known as the causative virus of MAIDS, we expressed and purified the gag
CD70 expression on T-cell subpopulations: study of normal individuals and patients with chronic immune activation.: Immunol Lett. 1997 Feb;55(2):99-104. Unique Identifier : AIDSLINE MED/97289017; Brugnoni D; Airo P; Marino R; Notarangelo LD; van Lier RA; Cattaneo R; Clinical Immunology Service, Spedali Civili/University of Brescia,; Italy.; CD70, the ligand of CD27, is a member of the TNF family, which includes molecules essential in the regulation of lymphocyte growth and survival. It is absent on resting lymphocytes but can be induced in vitro with activating stimuli. To extend information about its expression by different T-cell subpopulations, and it
Characterization of a series of vacuolar type H(+)-ATPase inhibitors on CTL-mediated cytotoxicity.: Immunol Lett. 1997 Mar;55(3):139-44. Unique Identifier : AIDSLINE MED/97305621; Togashi K; Kataoka T; Nagai K; Department of Bioengineering, Tokyo Institute of Technology, Yokohama,; Japan.; Four vacuolar type H(+)-ATPase (V-ATPase) inhibitors, i.e. concanamycin A (CMA), bafilomycin A1 (BMA), destruxin E (DRE) and prodigiosin 25-C (PRG) profoundly blocked the perforin-dependent cytotoxicity mediated by CD8+ CTL clone. Cytoplasmic acidic compartments were not detected under fluorescent microscopy after tre
Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T-cell clone.: Immunol Lett. 1997 Mar;55(3):145-9. Unique Identifier : AIDSLINE MED/97305622; Buseyne F; Stevanovic S; Rammensee HG; Riviere Y; Unite de virologie et d'immunologie cellulaire, URA CNRS 1157,; Institut Pasteur, Paris, France.; A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401
Autologous lymphoblastoid cell lines stably transfected with Plasmodium falciparum circumsporozoite protein as targets in cytotoxic T-lymphocyte assays.: Immunol Lett. 1997 Mar;55(3):183-7. Unique Identifier : AIDSLINE MED/97305628; Kumar A; Kang YH; Gowda K; Mullen CA; Gordon DM; Kumar S; Hoffman SL; Malaria Program, Naval Medical Research Institute, Bethesda, MD, USA.; To produce cell lines that can be used as a continuous source of antigen presenting cells for stimulating T-cell lines and clones and as targets in cytotoxic T-lymphocyte (CTL) assays, we used a retroviral vector with a simian virus (SV40) early promotor to transfer a Plasmodium falciparum circumporozoite (PfCSP) gene
Immunohistochemical analysis of procathepsin L and cathepsin B in cutaneous Kaposi's sarcoma.: Int J Dermatol. 1997 Feb;36(2):100-3. Unique Identifier : AIDSLINE MED/97262796; Thewes M; Engst R; Jurgens M; Borelli S; Department of Dermatology, Technical University of Munich, Germany.; BACKGROUND: The expression of the proteinases cathepsins L and B are induced in tumors by malignant transformation, growth factors, and tumor promoters suggesting they play an important role in tumor invasion and metastasis. METHODS: By immunohistochemistry, procathepsin L and cathepsin B were studied in patients with
Pityriasis lichenoides et varioliformis acuta in HIV-1+ patients: a marker of early stage disease. The Military Medical Consortium for the Advancement of Retroviral Research (MMCARR).: Int J Dermatol. 1997 Feb;36(2):104-9. Unique Identifier : AIDSLINE MED/97262797; Smith KJ; Nelson A; Skelton H; Yeager J; Wagner KF; Medical Research Institute of Chemical Defense, Aberdeen, Maryland,; USA.; BACKGROUND: The high incidence of cutaneous disease in HIV-1+ patients may be a marker of the chronic state of immune activation. In addition, specific cutaneous diseases may be related to the pattern and degree of immune dysregulation present in the patients at the time of the eruption. We have observed that HIV-1+ p
A metal-induced conformational change and activation of HIV-1 integrase.: J Biol Chem. 1997 Jun 27;272(26):16196-205. Unique Identifier : AIDSLINE MED/97341150; Asante-Appiah E; Skalka AM; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia,; Pennsylvania 19111, USA.; Retroviral integrases are composed of three independently folding domains whose organization relevant to one another is largely unknown. As an approach to understanding its structure, we have investigated the effect of the required metal cofactor(s), Mn2+ or Mg2+, on the conformation of human immunodeficiency virus ty
Willingness to provide care and treatment for patients with HIV/AIDS.: J Adv Nurs. 1997 May;25(5):1033-9. Unique Identifier : AIDSLINE MED/97292698; McCann TV; Faculty of Nursing, University of Newcastle, Callaghan, New South; Wales, Australia.; This paper is derived from the findings of a larger study which examines nurses and doctors attitudes towards mainstreaming of hospital inpatient services for individuals with HIV/AIDS in general hospital wards. The aim of this paper is to discuss the factors which influence nurses and doctors willingness to provi
On situating homophobia.: J Am Psychoanal Assoc. 1997;45(1):201-15. Unique Identifier : AIDSLINE MED/97266915; Moss D; Psychoanalytic Institute at New York University Medical Center, SUNY; Health Science Center at Brooklyn.; Premised on the observation that the HIV epidemic has occasioned an increase in both the prevalence and the virulence of homophobic ideation, feeling, and action, this paper surveys some of the ways in which psychoanalytic theory has been widely used in the emerging extraclinical literature on this problem. The proble
Inhibition of primary and recall allergen-specific T helper cell type 2-mediated responses by a T helper cell type 1 stimulus.: J Immunol. 1997 Jul 1;159(1):107-16. Unique Identifier : AIDSLINE MED/97343918; Scott DE; Agranovich I; Inman J; Gober M; Golding B; Center for Biologics Evaluation and Research, Division of Hematology,; Food and Drug Administration, Bethesda, MD 20892, USA.; Allergic responses are characterized by the production of Ag-specific IgE Abs that are dependent upon Th2-mediated T cell help. We determined whether heat-killed Brucella abortus (BA), an inducer of Th1 responses, could influence the allergic Th2-mediated IgE response to OVA adsorbed to alum (O/A). BA plus O/A, but no
Expression and role in apoptosis of the alpha- and beta-chains of the IFN-gamma receptor on human Th1 and Th2 clones.: J Immunol. 1997 Jul 1;159(1):206-13. Unique Identifier : AIDSLINE MED/97343929; Novelli F; D'Elios MM; Bernabei P; Ozmen L; Rigamonti L; Almerigogna F; Forni G; Del Prete G; Department of Clinical and Biological Sciences, University of Turin,; Orbassano, Italy. orb.imm@inrete.it; The mRNA and protein expression of the alpha- and beta-chains of IFN-gammaR were evaluated on a panel of human Th1 and Th2 clones. When cultured in IL-2-conditioned medium, both types of clones expressed mRNA for the alpha- and beta-chains, and both chains were present in the cytoplasm. Membrane expression of the alph
Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope.: J Immunol. 1997 Jul 1;159(1):279-89. Unique Identifier : AIDSLINE MED/97343937; Garrity RR; Rimmelzwaan G; Minassian A; Tsai WP; Lin G; de Jong JJ; Goudsmit J; Nara PL; Division of Basic Sciences, National Cancer Institute-Frederick Cancer; Research and Development Center (NCI-FCRDC), MD 21702, USA.; garrity@sri.org; Immunodominant epitopes are known to suppress a primary immune response to other antigenic determinants by a number of mechanisms. Many pathogens have used this strategy to subvert the immune response and may be a mechanism responsible for limited vaccine efficacies. HIV-1 vaccine efficacy appears to be complicated si
Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis.: J Immunol. 1997 Jul 1;159(1):290-7. Unique Identifier : AIDSLINE MED/97343938; Tan JS; Canaday DH; Boom WH; Balaji KN; Schwander SK; Rich EA; Department of Medicine, Case Western Reserve University, Cleveland, OH; 44106, USA.; T cell-mediated cytotoxicity against Mycobacterium tuberculosis MTB)-infected macrophages may be a major mechanism of specific host defense, but little is known about such activities in the lung. Thus, the capacity of alveolar lymphocyte MTB-specific cell lines (AL) and alveolar macrophages (AM) from tuberculin skin t
Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response.: J Immunol. 1997 Jul 1;159(1):3-6. Unique Identifier : AIDSLINE MED/97343903; Dalal M; Kim S; Voskuhl RR; UCLA Multiple Sclerosis Center, UCLA Department of Neurology, Los; Angeles, CA 90095, USA.; Female SJL mice are more susceptible than male mice to experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (MBP)-specific T lymphocytes. In the present study, we examined mechanisms involved in this gender-related difference in disease susceptibility. MBP-specific T lymphocytes derived from
IL-12 treatment attenuates T helper cell type 2 and B cell responses but does not improve vaccine-enhanced lung illness.: J Immunol. 1997 Jul 1;159(1):328-34. Unique Identifier : AIDSLINE MED/97343943; Hussell T; Khan U; Openshaw P; Department of Respiratory Medicine, Imperial College School of; Medicine, St. Mary's Hospital, Paddington, London, United Kingdom.; In humans and mice, sensitization to respiratory syncytial virus RSV) Ags can result in severe inflammatory lung disease during subsequent infection with RSV. Although specific antiviral T cells are thought to be responsible for this augmentation of disease, the precise roles of different functional subsets are unknow
A mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma: role of macrophage-inflammatory protein 1alpha.: J Immunol. 1997 Jul 1;159(1):360-8. Unique Identifier : AIDSLINE MED/97343947; Maric M; Chen L; Sherry B; Liu Y; Department of Pathology, New York University Medical Center, NY 10016,; USA.; An important aspect of immunity is the recruitment and accumulation of lymphocytes into target tissues where Ags are localized. Because the TCR recognizes antigenic peptides presented by MHC molecules, the subset of T cells that exert effector function is determined by the class of MHC molecules expressed on a given t
Clonal expansion of CD8+ T cells in Kawasaki disease.: J Immunol. 1997 Jul 1;159(1):481-6. Unique Identifier : AIDSLINE MED/97343962; Choi IH; Chwae YJ; Shim WS; Kim DS; Kwon DH; Kim JD; Kim SJ; Department of Microbiology, Yonsei University College of Medicine,; Seodaemoon-ku, Seoul, Korea. inhong@yumc.yonsei.ac.kr; Kawasaki disease (KD) is the major cause of acquired heart disease in children. KD is suspected of being an infectious disease, but the etiology has not yet been clarified. Immunologically, the disease is associated with the activation of T cells, monocytes, and macrophages resulting in highly elevated levels of sever
Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.: J Immunol. 1997 Jul 1;159(1):53-60. Unique Identifier : AIDSLINE MED/97343911; Faith A; Akdis CA; Akdis M; Simon HU; Blaser K; Swiss Institute of Allergy and Asthma Research, Davos.; SIAF@siaf.unizh.ch; Development of IgE-mediated allergic conditions is dependent on the secretion of a Th2 cytokine pattern, including IL-4, IL-5, and IL-13. The induction of anergy would be one mechanism to abrogate cytokine secretion by Th2 cells, which may be pivotal to the allergic response. We demonstrate here that incubation of clo
Perspective: validating surrogate markers--are we being naive?: J Infect Dis. 1997 Feb;175(2):237-46. Unique Identifier : AIDSLINE MED/97347304; De Gruttola V; Fleming T; Lin DY; Coombs R; Department of Biostatistics, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; Because of the difficulties in conducting studies of clinical efficacy of new therapies for human immunodeficiency virus infection and other diseases, there is increasing interest in using measures of biologic activity as surrogates for clinical end points. A widely used criterion for evaluating whether such measures
Longitudinal analysis of quantitative virologic measures in human immunodeficiency virus-infected subjects with > or = 400 CD4 lymphocytes: implications for applying measurements to individual patients. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.: J Infect Dis. 1997 Feb;175(2):247-54. Unique Identifier : AIDSLINE MED/97347305; Paxton WB; Coombs RW; McElrath MJ; Keefer MC; Hughes J; Sinangil F; Chernoff D; Demeter L; Williams B; Corey L; Department of Laboratory Medicine, Center for AIDS Research,; University of Washington, Seattle 98144, USA.; The natural variability of quantitative virologic measures among human immunodeficiency virus (HIV) type 1-infected persons was prospectively studied in 29 untreated persons with >600 CD4 cells/microL and in 15 persons receiving zidovudine monotherapy who had 400-550 CD4 cells/microL at study entry. Cell- and plasma-a
A randomized trial (ISS 902) of didanosine versus zidovudine in previously untreated patients with mildly symptomatic human immunodeficiency virus infection.: J Infect Dis. 1997 Feb;175(2):255-64. Unique Identifier : AIDSLINE MED/97347306; Floridia M; Vella S; Seeber AC; Tomino C; Fragola V; Weimer LE; Ricciardulli D; Milazzo F; Gritti FM; Mazzotta F; Ranieri S; Chiodo F; Moroni M; Cargnel A; Bassetti D; Giannini V; Cremoni L; Concia E; Sinicco A; Carosi G; Alberici F; Dianzani F; Laboratory of Virology, Istituto Superiore di Sanita, Ospedale; LazzaroSpallanzani, University La Sapienza, Rome, Italy.; In this multicenter study (ISS 902), 554 previously untreated patients with
Mucosal immune responses in four distinct compartments of women infected with human immunodeficiency virus type 1: a comparison by site and correlation with clinical information.: J Infect Dis. 1997 Feb;175(2):265-71. Unique Identifier : AIDSLINE MED/97347307; Artenstein AW; VanCott TC; Sitz KV; Robb ML; Wagner KF; Veit SC; Rogers AF; Garner RP; Byron JW; Burnett PR; Birx DL; Division of Retrovirology, Walter Reed Army Institute of Research and; Henry M. Jackson Foundation, Rockville, Maryland 20850, USA.; Because mucosal immune responses may be important in protection against human immunodeficiency virus type 1 (HIV-1), HIV-1-specific immune responses at mucosal sites in natural infection were compared. Total antibody concentrations and HIV-1-specific binding antibody responses in four distinct mucosal sites and serum
Detection of clonal T cell populations with closely related T cell receptor junctional sequences in persons at high risk for human immunodeficiency virus (HIV) infection and in patients acutely infected with HIV.: J Infect Dis. 1997 Feb;175(2):272-82. Unique Identifier : AIDSLINE MED/97347308; Bettinardi A; Imberti L; Sottini A; Quiros-Roldan E; Puoti M; Castelli F; Cadeo GP; Gorla R; Primi D; Consorzio per le Biotecnologie, Spedali Civili di Brescia, Italy.; The T cell repertoires were characterized for CD4+ and CD4 lymphocytes derived from 2 patients with acute human immunodeficiency virus (HIV) infection and from 25 HIV-seronegative persons at high risk for acquiring HIV. Oligoclonal expansions of CD4 cells were detected in the HIV-infected patients and in 2 of 3 uninfe
Safety and pharmacokinetics of hyperimmune anti-human immunodeficiency virus (HIV) immunoglobulin administered to HIV-infected pregnant women and their newborns. Pediatric AIDS Clinical Trials Group Protocol 185 Pharmacokinetic Study Group.: J Infect Dis. 1997 Feb;175(2):283-91. Unique Identifier : AIDSLINE MED/97347309; Lambert JS; Mofenson LM; Fletcher CV; Moye J Jr; Stiehm ER; Meyer WA 3rd; Nemo GJ; Mathieson BJ; Hirsch G; Sapan CV; Cummins LM; Jimenez E; O'Neill E; Kovacs A; Stek A; Institute of Human Virology, University of Maryland, Baltimore 21201,; USA.; The pharmacokinetics and safety of hyperimmune anti-human immunodeficiency virus (HIV) intravenous immunoglobulin (HIVIG) were evaluated in the first 28 maternal-infant pairs enrolled in a randomized, intravenous immunoglobulin (IVIG)-controlled trial of HIVIG maternal-infant HIV transmission prophylaxis. Using 200 mg
Proteosomes, emulsomes, and cholera toxin B improve nasal immunogenicity of human immunodeficiency virus gp160 in mice: induction of serum, intestinal, vaginal, and lung IgA and IgG.: J Infect Dis. 1997 Feb;175(2):292-301. Unique Identifier : AIDSLINE MED/97347310; Lowell GH; Kaminski RW; VanCott TC; Slike B; Kersey K; Zawoznik E; Loomis-Price L; Smith G; Redfield RR; Amselem S; Birx DL; Division of Pathology, Walter Reed Army Institute of Research,; Washington, DC, USA.; Intranasal immunization of mice with human immunodeficiency virus HIV) rgp160 complexed to proteosomes improved anti-gp160 serum IgA and IgG titers, increased the number of gp160 peptides recognized, and stimulated anti-gp160 intestinal IgA compared with immunization with uncomplexed rgp160 in saline. These enhanced r
Utility of urine and leukocyte cultures and plasma DNA polymerase chain reaction for identification of AIDS patients at risk for developing human cytomegalovirus disease.: J Infect Dis. 1997 Feb;175(2):302-8. Unique Identifier : AIDSLINE MED/97347311; Shinkai M; Bozzette SA; Powderly W; Frame P; Spector SA; University of California, San Diego, and San Diego VA Medical Center,; La Jolla 92093-0672, USA.; Urine and blood leukocyte cultures and qualitative plasma polymerase chain reaction (PCR) and quantitative competitive (QC) PCR were evaluated for their ability to identify AIDS patients at risk for human cytomegalovirus (HCMV) disease. AIDS patients were followed with urine and bl
Full or partial seroreversion in patients infected by hepatitis C virus.: J Infect Dis. 1997 Feb;175(2):316-22. Unique Identifier : AIDSLINE MED/97347313; Lefrere JJ; Guiramand S; Lefrere F; Mariotti M; Aumont P; Lerable J; Petit JC; Girot R; Morand-Joubert L; Institut National de la Transfusion Sanguine, Hopital Saint-Antoine,; Paris, France.; Cases of partial seroreversion have been reported in hemodialyzed or immunodepressed patients, but spontaneous clearance of viremia associated with a disappearance of specific antibodies or clearance while receiving therapy has not been precisely documented in immunocompetent hepatitis C virus (HCV)-infected persons.
Bacterial antigen activation of Vdelta1 and Vdelta2 gammadelta T cells of persons infected with human immunodeficiency virus type 1.: J Infect Dis. 1997 Feb;175(2):429-33. Unique Identifier : AIDSLINE MED/97347326; Chervenak KA; Lederman MM; Boom WH; Department of Medicine, Case Western Reserve University School of; Medicine and University Hospitals of Cleveland, Ohio 44106-4984, USA.; Vdelta2 gammadelta T cells are readily activated by microbial antigens. In persons infected with human immunodeficiency virus type 1 (HIV-1), the number of gammadelta T cells remains the same or increases in association with reversal of the Vdelta2/Vdelta1 ratio from > or = 1 to
The effect on human immunodeficiency virus type 1 RNA levels in cerebrospinal fluid after initiation of zidovudine or didanosine.: J Infect Dis. 1997 Feb;175(2):434-7. Unique Identifier : AIDSLINE MED/97347327; Gisslen M; Norkrans G; Svennerholm B; Hagberg L; Department of Infectious Diseases, Goteborg University, Sweden.; Human immunodeficiency virus type 1 (HIV-1) RNA, neopterin, and beta2-microglobulin levels were analyzed in cerebrospinal fluid CSF) and serum before and 3-13 months after initiation of antiretroviral monotherapy in 16 HIV-1-infected persons. Twenty-one treatment periods, 13 after initiation of zidovudine and 8 after
Human T cell lymphotropic virus type I does not increase human immunodeficiency virus viral load in vivo [see comments]: J Infect Dis. 1997 Feb;175(2):438-40. Unique Identifier : AIDSLINE MED/97347328; Harrison LH; Quinn TC; Schechter M; Department of Epidemiology, University of Pittsburgh Graduate School; of Public Health, Pennsylvania 15261, USA. LHARRISO+@PITT.EDU; Human T lymphotropic virus type I (HTLV-I) can increase human immunodeficiency virus (HIV) replication in vitro, and several studies suggest that HTLV-I accelerates the progression of HIV infection. To determine whether HTLV-I enhances HIV replication in vivo, a case-control study was done of serum HIV viral load, usi
JC virus (JCV) genotypes in brain tissue from patients with progressive multifocal leukoencephalopathy (PML) and in urine from controls without PML: increased frequency of JCV type 2 in PML.: J Infect Dis. 1997 Jul;176(1):1-8. Unique Identifier : AIDSLINE MED/97350967; Agostini HT; Ryschkewitsch CF; Mory R; Singer EJ; Stoner GL; Laboratory of Experimental Neuropathology, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, Maryland 20892-4126, USA.; Progressive multifocal leukoencephalopathy (PML) is caused by the human polyomavirus JC (JCV), and there are at least 4 different genotypes of JCV in the United States . Type 1 strains are of European origin, whereas type 2 and 3 strains are of Asian and African origin, respectively. JC
Evaluation of sorivudine (BV-araU) versus acyclovir in the treatment of acute localized herpes zoster in human immunodeficiency virus-infected adults. The Multinational Sorivudine Study Group.: J Infect Dis. 1997 Jul;176(1):103-11. Unique Identifier : AIDSLINE MED/97350979; Bodsworth NJ; Boag F; Burdge D; Genereux M; Borleffs JC; Evans BA; Modai J; Colebunders R; Thomas M; DeHertogh D; Pacelli L; Thomis J; Sydney Hospital and Taylor Square Private Clinic, Australia.; The clinical efficacy and safety of sorivudine as treatment for acute cutaneous zoster in human immunodeficiency virus-infected adults was compared with that of acyclovir in a double-blinded randomized study. A total of 125 patients with laboratory-confirmed zoster rash present
Incidence and prognostic significance of symptomatic primary human immunodeficiency virus type 1 infection in homosexual men.: J Infect Dis. 1997 Jul;176(1):112-7. Unique Identifier : AIDSLINE MED/97350980; Veugelers PJ; Kaldor JM; Strathdee SA; Page-Shafer KA; Schechter MT; Coutinho RA; Keet IP; van Griensven GJ; British Columbia Centre for Excellence in HIV/AIDS and Department of; Health Care and Epidemiology, University of British Columbia,; Vancouver, Canada.; To investigate the incidence of symptomatic primary human immunodeficiency virus type 1 (HIV-1) infection and its prognostic significance for HIV-1 disease progression, data for 328 homosexual men from four cohort studies were evaluated. Rates of diarrhea, fever, night sweats, cough, and fatigue prior to, during, and
Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL), virus load, and CD4 T cell loss: evidence supporting a protective role for CTL in vivo.: J Infect Dis. 1997 Jul;176(1):118-25. Unique Identifier : AIDSLINE MED/97350981; Greenough TC; Brettler DB; Somasundaran M; Panicali DL; Sullivan JL; Program in Molecular Medicine, University of Massachusetts Medical; School, Medical Center of Central Massachusetts-Memorial Hospital,; Worcester 01605, USA.; The relationships between primary human immunodeficiency virus type 1 (HIV-1) Gag-specific cytotoxic T lymphocyte (CTL) frequency, virus load, and CD4 T cell loss were evaluated in a group of 46 HIV-1-infected persons with hemophilia. Freshly isolated peripheral blood mononuclear cells in limiting dilution assays were
Early manifestations of disseminated Mycobacterium avium complex disease: a prospective evaluation.: J Infect Dis. 1997 Jul;176(1):126-32. Unique Identifier : AIDSLINE MED/97350982; Gordin FM; Cohn DL; Sullam PM; Schoenfelder JR; Wynne BA; Horsburgh CR Jr; Division of Infectious Diseases, Department of Veterans Affairs; Medical Center, and Georgetown University, Washington, DC 20422, USA.; A nested case-control study was conducted in two trials of prophylaxis for Mycobacterium avium complex (MAC) infection to describe the specific signs, symptoms, and laboratory abnormalities of MAC disease in AIDS. Patients had
Surrogate marker of preclinical tuberculosis in human immunodeficiency virus infection: antibodies to an 88-kDa secreted antigen of Mycobacterium tuberculosis.: J Infect Dis. 1997 Jul;176(1):133-43. Unique Identifier : AIDSLINE MED/97350983; Laal S; Samanich KM; Sonnenberg MG; Belisle JT; O'Leary J; Simberkoff MS; Zolla-Pazner S; VA Medical Center, and Department of Pathology, New York University; Medical Center, New York 10010, USA.; Antibodies to purified, size-fractionated secreted proteins of Mycobacterium tuberculosis in sera from patients with human immunodeficiency virus (HIV) infection and active tuberculosis HIV/TB patients), and in stored sera obtained from the same patients prior to clinical manifestation of TB, were evaluated by ELISA,
Comparison of a tuberculin interferon-gamma assay with the tuberculin skin test in high-risk adults: effect of human immunodeficiency virus infection.: J Infect Dis. 1997 Jul;176(1):144-50. Unique Identifier : AIDSLINE MED/97350984; Converse PJ; Jones SL; Astemborski J; Vlahov D; Graham NM; Department of Molecular Microbiology and Immunology, Johns Hopkins; University School of Hygiene and Public Health, Baltimore, Maryland,; USA.; A novel, whole blood interferon-gamma (IFN-gamma) assay was evaluated to determine its suitability for detecting Mycobacterium tuberculosis exposure in intravenous drug users with or without human immunodeficiency virus (HIV) infection. Whole heparinized blood was incubated overnight in separate wells with tuberculin
Induction of protective Th1 responses to Candida albicans by antifungal therapy alone or in combination with an interleukin-4 antagonist.: J Infect Dis. 1997 Jul;176(1):217-26. Unique Identifier : AIDSLINE MED/97350994; Cenci E; Mencacci A; Del Sero G; Bistoni F; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; Resistance or susceptibility to disseminated and mucosal Candida albicans infections in mice correlates with the development of protective or nonprotective T helper (Th) cell responses. To determine whether immunomodulatory activity on Th cell functions is an effect beyond that provided by antifungal therapy, mice wit
Chronic varicella-zoster virus skin lesions in patients with human immunodeficiency virus are related to decreased expression of gE and gB.: J Infect Dis. 1997 Jul;176(1):261-4. Unique Identifier : AIDSLINE MED/97351002; Nikkels AF; Rentier B; Pierard GE; Department of Dermatopathology, Institute of Pathology, University of; Liege, Belgium.; The pathogenesis of chronic, verrucous varicella-zoster virus VZV) cutaneous lesions in human immunodeficiency virus HIV)-infected persons is unknown. It has been hypothesized that these lesions are due to an altered pattern of virus gene expression. Immediate early and late (L) gene expression in five chronic verruco
Antagonism between human immunodeficiency virus type 1 protease inhibitors indinavir and saquinavir in vitro.: J Infect Dis. 1997 Jul;176(1):265-8. Unique Identifier : AIDSLINE MED/97351003; Merrill DP; Manion DJ; Chou TC; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston 02114, USA.; Human immunodeficiency virus type 1 (HIV-1) protease inhibitors are a promising class of antiretroviral agents that compromise enzymatic function through substrate mimicry. The in vitro susceptibility of a panel of HIV-1 clinical isolates demonstrating various drug
Clinical relevance of parvovirus B19 as a cause of anemia in patients with human immunodeficiency virus infection.: J Infect Dis. 1997 Jul;176(1):269-73. Unique Identifier : AIDSLINE MED/97351004; Abkowitz JL; Brown KE; Wood RW; Kovach NL; Green SW; Young NS; Department of Medicine, University of Washington, Seattle 98195-7710,; USA.; Parvovirus B19 (B19) DNA was detected by dot blot hybridization in sera from 5 (17%) of 30 human immunodeficiency virus HIV)-infected patients with hematocrits (HCT) of
Human T cell lymphotropic virus type II and human immunodeficiency virus type 1 disease progression [letter; comment]: J Infect Dis. 1997 Jul;176(1):308-9. Unique Identifier : AIDSLINE MED/97351014; Harrison LH; Schechter M
Cytomegalovirus (CMV) culture results, drug resistance, and clinical outcome in patients with AIDS and CMV retinitis treated with foscarnet or ganciclovir. Studies of Ocular Complications of AIDS (SOCA) in collaboration with the AIDS Clinical Trial Group.: J Infect Dis. 1997 Jul;176(1):50-8. Unique Identifier : AIDSLINE MED/97350973; The objectives of the study were to examine the clinical significance of cytomegalovirus ( CMV ) culture results and drug susceptibilities in CMV isolates from patients with AIDS-related CMV retinitis. Blood and urine for CMV c
Detection of human herpesvirus 8 DNA in Kaposi's sarcoma lesions and peripheral blood of human immunodeficiency virus-positive patients and correlation with serologic measurements.: J Infect Dis. 1997 Jul;176(1):84-93. Unique Identifier : AIDSLINE MED/97350977; Smith MS; Bloomer C; Horvat R; Goldstein E; Casparian JM; Chandran B; Department of Microbiology, Molecular Genetics, and Immunology,; University of Kansas Medical Center, Kansas City 66160-7420, USA.; Polymerase chain reaction (PCR) was used to examine human herpesvirus 8 (HHV-8) DNA from Kaposi s sarcoma (KS) lesions, normal skin, and peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-infected patients who did or did not have KS. Of 9 KS biopsies, 8 were positive for five HHV-8 open-
Frequent detection of Kaposi's sarcoma-associated herpesvirus human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates.: J Infect Dis. 1997 Jul;176(1):94-102. Unique Identifier : AIDSLINE MED/97350978; Koelle DM; Huang ML; Chandran B; Vieira J; Piepkorn M; Corey L; Department of Medicine, University of Washington School of Medicine,; Seattle, USA.; The prevalence, quantity, temporal pattern, and clinical and immunologic correlates of shedding of Kaposi s sarcoma KS)-associated herpesvirus (KSHV; or human herpesvirus [HHV]-8) DNA in saliva were studied. KSHV DNA was detected in saliva from 18 (75%) of 24 human immunodeficiency virus (HIV)-positive patients with K
Adherence in AIDS clinical trials: a framework for clinical research and clinical care.: J Clin Epidemiol. 1997 Apr;50(4):385-91. Unique Identifier : AIDSLINE MED/97322606; Ickovics JR; Meisler AW; Department of Internal Medicine, Yale University, New Haven,; Connecticut, USA.; Assessment of adherence within AIDS clinical trials is a critical component of the successful evaluation of therapeutic outcomes. Poor medication adherence can result in the misinterpretation of clinical trial data. Research on factors affecting adherence in AIDS clinical trials has been scarce, and few investigations
Relationship between human immunodeficiency virus-1 RNA identification in placenta and perinatal transmission.: J Perinatol. 1997 Mar-Apr;17(2):119-24. Unique Identifier : AIDSLINE MED/97280141; Katz JM; Fox CH; Eglinton GS; Meyers WA 3rd; Queenan JT; Georgetown University Medical Center, Washington, D.C., USA.; OBJECTIVES: The objectives of this study were to identify human immunodeficiency virus (HIV)-associated nucleic acids in placenta with 35S RNA in situ hybridization and to correlate the presence of virus with perinatal HIV transmission. STUDY DESIGN: Blood from nine mother-infant pairs was collected for CD4+ lymphocyt
Cryptosporidium in patients infected with human immunodeficiency virus: azithromycin revisited [letter; comment]: J Pediatr. 1997 Jun;130(6):1009-10. Unique Identifier : AIDSLINE MED/97346211; Ramos JT; Saavedra J; Ruiz-Contreras J
Vertical transmission of hepatitis C: to screen or not to screen [editorial; comment]: J Pediatr. 1997 Jun;130(6):859-61. Unique Identifier : AIDSLINE MED/97346185; Zein NN
Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection. New York City Perinatal HIV Transmission Collaborative Study Group.: J Pediatr. 1997 Jun;130(6):890-7. Unique Identifier : AIDSLINE MED/97346190; Lambert G; Thea DM; Pliner V; Steketee RW; Abrams EJ; Matheson P; Thomas PA; Greenberg B; Brown TM; Bamji M; Kalish ML; Department of Pediatrics, Bronx Lebanon Hospital Center, NY 10457,; USA.; Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers, we correlated infant outcome with material CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infan
Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease. A retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children.: J Pediatr. 1997 Jun;130(6):898-905. Unique Identifier : AIDSLINE MED/97346191; Zaknun D; Orav J; Kornegay J; al-Attar I; Fuchs D; Zaknun J; Wachter H; Chatis P; Burchett SK; McIntosh K; Division of Infectious Diseases, Children's Hospital, Boston MA 02115,; USA.; OBJECTIVE: We investigated the relationship between cell-free viral load, neopterin, age-adjusted CD4+ cell concentration, and clinical events in 49 children with vertically acquired human immunodeficiency virus type 1 infection. STUDY DESIGN: Viral load was measured by quantitating viral ribonucleic acid in serum by
Zidovudine administered to women infected with human immunodeficiency virus type 1 and to their neonates reduces pediatric infection independent of an effect on levels of maternal virus.: J Pediatr. 1997 Jun;130(6):906-14. Unique Identifier : AIDSLINE MED/97346192; Aleixo LF; Goodenow MM; Sleasman JW; Department of Pediatrics, University of Florida College of Medicine,; Gainesville 32610, USA.; OBJECTIVE: To determine whether zidovudine, administered to reduce vertical transmission of human immunodeficiency virus type 1 (HIV-1), impacts the level of maternal viral DNA within the lymphocytes of infected pregnant women. STUDY DESIGN: A prospective, nonrandomized study of 42 HIV-1 infected pregnant women. Ninet
Impaired early growth of infants perinatally infected with human immunodeficiency virus: correlation with viral load.: J Pediatr. 1997 Jun;130(6):915-22. Unique Identifier : AIDSLINE MED/97346193; Pollack H; Glasberg H; Lee E; Nirenberg A; David R; Krasinski K; Borkowsky W; Oberfield S; Divisions of Pediatric Infectious Diseases, New York University; Medical Center, New York 10016, USA.; OBJECTIVE: To evaluate the effect of viral load on the early growth of infants infected with human immunodeficiency virus HIV). METHODS: Plasma concentrations of p24-antigen and HIV ribonucleic acid were measured retrospectively and correlated with growth parameters for the first 18 months of life in a cohort of 47 te
Hepatitis C virus infection and related liver disease in children of mothers with antibodies to the virus [see comments]: J Pediatr. 1997 Jun;130(6):990-3. Unique Identifier : AIDSLINE MED/97346205; Bortolotti F; Resti M; Giacchino R; Azzari C; Gussetti N; Crivellaro C; Barbera C; Mannelli F; Zancan L; Bertolini A; Department of Clinical and Experimental Medicine, University of Padua,; Italy.; OBJECTIVE: To evaluate the clinical, biochemical, and virologic features associated with hepatitis C virus (HCV) infection acquired early in life from mothers with antibodies to HCV anti-HCV). STUDY DESIGN: Multicenter prospective-retrospective study in Italian children. PATIENTS: Two groups of children were investiga
Human immunodeficiency virus type 2 infection in children.: J Pediatr. 1997 Jun;130(6):994-7. Unique Identifier : AIDSLINE MED/97346206; Faye A; Burgard M; Crosnier H; Retbi JM; Blanche S; Departement de Pediatrie et Laboratoire de Virologie, Hopital; Necker-Enfants Malades, Paris, France.; Human immunodeficiency virus type 2 infection is rare in children. This virus can be acquired through transfusion and also by the maternofetal route, especially when the mother becomes infected during pregnancy. Diagnosis based on specific serologic tests is simple after the age of 18 months. In the perinatal period,
Idiopathic esophageal ulcers in a child with AIDS.: J Pediatr Gastroenterol Nutr. 1997 Feb;24(2):211-4. Unique Identifier : AIDSLINE MED/97260010; Narwal S; Galeano NF; Pottenger E; Kazlow PG; Husain S; DeFelice AR; Department of Pediatrics, Babies and Children's Hospital, Columbia; University, New York, New York, USA.
Atypical strains of Candida albicans recovered from AIDS patients.: J Med Vet Mycol. 1997 Mar-Apr;35(2):115-21. Unique Identifier : AIDSLINE MED/97292760; Pujol C; Renaud F; Mallie M; de Meeus T; Bastide JM; Laboratoire d'Immunologie-Parasitologie, Faculte de Pharmacie,; Montpellier, France.; By using multilocus enzyme electrophoresis (MLEE) we have analyzed the genetic diversity encountered among chlamydospore-positive Candida albicans strains. While the type II strains of the former C. stellatoidea were genetically indistinguishable from those of C. albicans, type I strains constituted a distinct subgrou
New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance.: J Med Vet Mycol. 1997 Mar-Apr;35(2):133-7. Unique Identifier : AIDSLINE MED/97292762; Walsh TJ; Kasai M; Francesconi A; Landsman D; Chanock SJ; Infectious Diseases Section, National Cancer Institute, Bethesda, MD; 20892, USA.; Emergence of resistance of Candida albicans to antifungal triazoles is increasingly recognized as an important cause of refractory mucosal candidiasis in HIV-infected patients. Recently, CDR1, which is thought to be analogous to the human MDR-1 P-glycoprotein, has been cloned in C. albicans. It has been proposed that
Differential killer toxin sensitivity patterns of varieties of Cryptococcus neoformans.: J Med Vet Mycol. 1997 Mar-Apr;35(2):147-9. Unique Identifier : AIDSLINE MED/97292765; Boekhout T; Scorzetti G; Centraalbureau voor Schimmelcultures, Yeast Division, Delft, The; Netherlands. t.boekhout@stm.tudelft.nl; Ten different killer sensitivity types are distinguished within Cryptococcus neoformans, namely four in var. neoformans and six in var. gattii. All strains of the var. gattii investigated were inhibited by killer toxins of C. laurentii CBS 139, whereas those of the var. neoformans were not. Killer sensitivity patterns
Novel activation stimulus of chloride channels by potassium in human osteoblasts and human leukaemic T lymphocytes.: J Physiol (Lond). 1997 May 1;500 ( Pt 3):653-60. Unique Identifier : AIDSLINE MED/97305725; Steinert M; Grissmer S; Department of Applied Physiology, University of Ulm, Germany.; 1. The whole-cell recording mode of the patch-clamp technique was used to study the effect of extracellular K+ and Rb+ on membrane currents in human osteoblasts, in a human osteoblast-like cell line, and in the Jurkat human leukaemic T cell line. 2. Increasing the extracellular concentration of K+ increased the membra
Nonresponse bias in a survey of Ontario dentists' infection control and attitudes concerning HIV.: J Public Health Dent. 1997 Winter;57(1):59-62. Unique Identifier : AIDSLINE MED/97294180; McCarthy GM; Koval JJ; MacDonald JK; Division of Oral Biology, Faculty of Medicine and Dentistry,; University of Western Ontario, London, Canada. gmccarth@julian.uwo.ca; OBJECTIVE: This study investigated late response and nonresponse bias in an HIV-related survey of dentists. METHODS: Questionnaires with ID numbers were mailed to all dentists in Ontario (N = 5,997) with additional mailings four and seven weeks later. RESULTS: Proportionately more respondents who returned questionnair
Synthesis and anti-HIV activity of novel N-1 side chain-modified analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine HEPT).: J Med Chem. 1997 Jun 6;40(12):1845-54. Unique Identifier : AIDSLINE MED/97335295; Pontikis R; Benhida R; Aubertin AM; Grierson DS; Monneret C; Institut Curie, Section Recherche, UMR CNRS 176, Paris, France.; A series of 33 N-1 side chain-modified analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (1, HEPT) were synthesized and evaluated for their anti-HIV-1 activity. In particular, the influence of substitution of the terminal hydroxy group of the acyclic structure of HEPT and the structural rigidity of this sid
Solution structure of r(gaggacug):d(CAGTCCTC) hybrid: implications for the initiation of HIV-1 (+)-strand synthesis.: J Mol Biol. 1997 Jun 6;269(2):225-39. Unique Identifier : AIDSLINE MED/97334370; Fedoroff OY; Ge Y; Reid BR; Chemistry Department, University of Washington, Seattle 98195, USA.; The three-dimensional solution structure of the hybrid duplex r(gaggacug):d(CAGTCCTC) has been determined by two-dimensional NMR, distance geometry (DG), restrained molecular dynamics (rMD) and NOE back-calculation methods. This hybrid, consisting of a purine-rich RNA strand and a pyrimidine-rich DNA strand, is relate
A comparison of AIDS-related sexual risk behaviors among African-American college students.: J Natl Med Assoc. 1997 Jun;89(6):397-403. Unique Identifier : AIDSLINE MED/97339245; Taylor SE; Dilorio C; Stephens TT; Soet JE; Department of Sociology, Clark Atlanta University, Georgia 30314, USA.; This article compares the sexual practices and risk-taking behaviors of African-American male and female college students (n = 649) attending 4-year institutions in a major southeastern metropolitan area. It is a descriptive study of the kinds of practices that put African-American college students at a high risk of c
Protease inhibitors and urolithiasis.: J Urol. 1997 Jul;158(1):31-3. Unique Identifier : AIDSLINE MED/97329857; Sutherland SE; Reigle MD; Seftel AD; Resnick MI; Department of Urology, Case Western Reserve University, Cleveland,; Ohio, USA.; PURPOSE: We discuss the specific urological abnormalities associated with protease inhibitor therapy. MATERIALS AND METHODS: We report on a human immunodeficiency virus positive patient who was on protease inhibitor therapy and presented with renal colic. RESULTS: The stone passed spontaneously. Stone analysis was not
Intraoperative autologous transfusion during elective infrarenal aortic reconstruction: a decision analysis model.: J Vasc Surg. 1997 Jun;25(6):984-93; discussion 993-4. Unique Identifier : AIDSLINE MED/97344791; Huber TS; McGorray SP; Carlton LC; Irwin PB; Flug RR; Flynn TC; Seeger JM; Department of Surgery, University of Florida College of Medicine,; Gainesville 32610-0286, USA.; PURPOSE: The use of intraoperative autologous transfusion devices expanded during the last decade as a result of the increased awareness of transfusion-associated complications. This study was designed to determine whether routine use of an intraoperative autologous transfusion device (Haemonetics Cell Saver [CS]) dur
Acute primary HIV infection [clinical conference]: JAMA. 1997 Jul 2;278(1):58-62. Unique Identifier : AIDSLINE MED/97350964; Quinn TC; Division of Infectious Diseases, The Johns Hopkins University School; of Medicine, Baltimore, MD 21205, USA.
Protease inhibitors in the homeless.: JAMA. 1997 Jul 2;278(1):63-5. Unique Identifier : AIDSLINE MED/97350965; Bangsberg D; Tulsky JP; Hecht FM; Moss AR; Center for AIDS Prevention Studies, AIDS Research Institute,; University of California, San Francisco 94143-1347, USA.
Cystic parotid gland enlargement in HIV disease. The diffuse infiltrative lymphocytosis syndrome.: JAMA. 1997 Jul 9;278(2):166-7. Unique Identifier : AIDSLINE MED/97357185; Schrot RJ; Adelman HM; Linden CN; Wallach PM; Medical Service, James A. Haley Veterans Hospital, Tampa, FL 33612,; USA.
[Approval of HIV protease inhibitors as the AIDS therapeutics of next generation]: Nippon Rinsho. 1997 May;55(5):1287-95. Unique Identifier : AIDSLINE MED/97300076; Kiso Y; Kyoto Pharmaceutical University.; The long-term usages of reverse transcriptase inhibitors as anti-HIV drugs have induced serious side effects and emergence of resistant viruses. To overcome these problems, combination therapies are expected to be effective. Under such circumstances, HIV protease inhibi
[Tuberculosis in patients with human immunodeficiency virus infection]: Nippon Kyobu Shikkan Gakkai Zasshi. 1997 Mar;35(3):267-72. Unique Identifier : AIDSLINE MED/97312108; Nagai H; Hebisawa A; Akagawa S; Kawabe Y; Shishido H; Kurashima A; Sato K; Mori M; Katayama T; Department of Pulmonary Diseases, Tokyo National Chest Hospital,; Japan.; Six men (mean age: 36.3 +/- 29 years) infected with the human immunodeficiency virus (HIV), four Japanese and two from Myammar, were admitted to our hospital for treatment of tuberculosis. In five, HIV positivity on serologic testing was first found when tuberculosis was diagnosed. The mean CD4 cell count was 37.3 +/-
Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL).: Leukemia. 1997 Jul;11(7):984-9. Unique Identifier : AIDSLINE MED/97348975; Hatta Y; Yamada Y; Tomonaga M; Koeffler HP; Department of Medicine, Cedars-Sinai Research Institute, UCLA School; of Medicine, Los Angeles, CA 90048, USA.; The retinoblastoma susceptibility gene (Rb) plays a key role in regulating the cell cycle in association with cyclins and cyclin-dependent kinases (CDKs). Alteration of the Rb gene as well as CDK inhibitors (CDKIs) leads to deregulated cellular growth which promotes cancer formation. We examined the genomic configurat
Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection.: Life Sci. 1997;60(25):PL383-7. Unique Identifier : AIDSLINE MED/97338023; Collins RA; Ng TB; Department of Biochemistry, The Chinese University of Hong Kong,; Shatin, New Territories. racollins@cuhk.edu.hk; Polysaccharopeptide (PSP) isolated from the edible mushroom Coriolus versicolor was tested for its potential as an anti-human immunodeficiency virus type 1 (HIV-1) compound in a series of in vitro assays. It demonstrated inhibition of the interaction between HIV-1 gp 120 and immobilized CD4 receptor (IC50 = 150 microg
The risk of transmitting HCV, HBV or HIV by blood transfusion in Victoria.: Med J Aust. 1997 Jun 2;166(11):584-6. Unique Identifier : AIDSLINE MED/97344811; Whyte GS; Savoia HF; Red Cross Blood Bank, Southbank, Victoria. gwhyte@rcbbv.org.au; OBJECTIVE: To report the incidence rate of hepatitis B virus HBV), hepatitis C virus (HCV) and HIV in Victorian repeat blood donors and to derive the residual risk of transmission of the viruses by screened blood transfusion. DESIGN: The interval from the previous whole blood donation was extracted retrospectively fro
The effectiveness of donor selection for reducing the risk of HCV, HBV and HIV in new blood donors [letter]: Med J Aust. 1997 Jun 2;166(11):611. Unique Identifier : AIDSLINE MED/97344818; Whyte GS; Savoia HF
1997 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. USPHS/IDSA Prevention of Opportunistic Infections Working Group.: MMWR Morb Mortal Wkly Rep. 1997 Jun 27;46(RR-12):1-46. Unique Identifier : AIDSLINE MED/97357376
Update: syringe-exchange programs--United States, 1996.: MMWR Morb Mortal Wkly Rep. 1997 Jun 20;46(24):565-8. Unique Identifier : AIDSLINE MED/97345918; As of December 1996, approximately one third (36%) of the 573,000 cases of acquired immunodeficiency syndrome (AIDS) among adults reported to CDC were directly or indirectly associated with injecting-drug use. Syringe-exchange programs (SEPs) are one of the strategies for preventing infection with human immunodeficien
Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes.: Mol Pharmacol. 1997 Jun;51(6):1007-14. Unique Identifier : AIDSLINE MED/97330832; Fujino H; Kitamura Y; Yada T; Uehara T; Nomura Y; Department of Pharmacology, Faculty of Pharmaceutical Sciences,; Hokkaido University, Sapporo, Japan.; It is known that there are some bidirectional interactions between the nervous and the immune systems via neurotransmitters and cytokines. To clarify whether any neurotransmitters modulate lymphocyte functions, we examined the effects of oxotremorine-M Oxo-M) on interleukin-2 (
Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway.: Mol Pharmacol. 1997 Jun;51(6):972-82. Unique Identifier : AIDSLINE MED/97330828; Szondy Z; Reichert U; Bernardon JM; Michel S; Toth R; Ancian P; Ajzner E; Fesus L; Department of Biochemistry, University Medical School of Debrecen,; Hungary.; Retinoic acids are morphogenic signaling molecules that are derived from vitamin A and involved in a variety of tissue functions. Two groups of their nuclear receptors have been identified: retinoic acid receptors (RARs) and retinoic acid X receptors (RXRs). All-trans retinoic acid is the high affinity ligand for RARs
Treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome.: N Engl J Med. 1997 Jul 10;337(2):105-14. Unique Identifier : AIDSLINE MED/97337879; Jacobson MA; Department of Medicine, University of California, San Francisco 94110,; USA.
Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. The Ganciclovir Implant Study Group.: N Engl J Med. 1997 Jul 10;337(2):83-90. Unique Identifier : AIDSLINE MED/97337875; Musch DC; Martin DF; Gordon JF; Davis MD; Kuppermann BD; Department of Ophthalmology, University of Michigan, Ann Arbor, USA.; BACKGROUND: Sustained-release, intraocular implants that deliver ganciclovir are an alternative method for the treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome (AIDS). METHODS: We conducted a randomized study of 188 patients with AIDS a
Blood lab boss jailed for neglect over HIV test [news]: Nature. 1997 Jun 26;387(6636):840. Unique Identifier : AIDSLINE MED/97345617
[AIDS epidemic in The Netherlands: current developments in transmission route, age and nationality]: Ned Tijdschr Geneeskd. 1997 Apr 26;141(17):830-5. Unique Identifier : AIDSLINE MED/97306859; Termorshuizen F; Houweling H; Bindels PJ; van Wijngaarden JK; Rijksinstituut voor Volksgezondheid en Milieu, Centrum voor; Infectieziekten Epidemiologie, Bilthoven.; OBJECTIVE: To document the recent developments in the course of the AIDS epidemic in the Netherlands , 1982-1995. DESIGN: Descriptive. SETTING: National Institute of Public Health and Environment, Bilthoven, Municipal Health Service, Amsterdam, and Inspectorate of Public Health
Vertical transmission of hepatitis C virus in New Zealand.: N Z Med J. 1997 May 9;110(1043):165-7. Unique Identifier : AIDSLINE MED/97339966; Croxson M; Couper A; Voss L; Groves D; Gunn T; Department of Virology and Immunology, University of Auckland, School; of Medicine.; AIMS: To investigate the transmission of hepatitis C virus from viraemic mothers to infants. METHODS: The study group comprised 54 hepatitis C ribonucleic acid (RNA) positive, human immunodeficiency virus (HIV) negative women attending antenatal clinic, their infants when born, 12 previous children and 44 children of
Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.: Ophthalmology. 1997 Jun;104(6):1049-57. Unique Identifier : AIDSLINE MED/97329989; Taskintuna I; Rahhal FM; Arevalo JF; Munguia D; Banker AS; De Clercq E; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California at San Diego, La Jolla 92093-0946, USA.; PURPOSE: The authors have shown that long-term treatment of cytomegalovirus ( CMV ) retinitis with 20-microgram intravitreal injections of cidofovir (HPMPC) is highly effective but may be associated with iritis and profound hyp
Pharmacokinetics and safety of concentration-controlled oral zidovudine therapy.: Pharmacotherapy. 1997 May-Jun;17(3):424-30. Unique Identifier : AIDSLINE MED/97308320; Acosta EP; Henry K; Page LM; Erice A; Balfour HH Jr; Fletcher CV; College of Pharmacy, University of Minnesota Health Sciences Center,; Minneapolis, USA.; STUDY OBJECTIVE: To evaluate the pharmacokinetics, safety, and feasibility of concentration-controlled oral zidovudine therapy. DESIGN: Randomized, crossover, open-label study. SETTING: University-affiliated general clinical research center. PATIENTS: Eight individuals infected with the human immunodeficiency virus wi
Effects of spontaneous gastric hypoacidity on the pharmacokinetics of zidovudine and didanosine.: Pharmacotherapy. 1997 May-Jun;17(3):438-44. Unique Identifier : AIDSLINE MED/97308322; Shelton MJ; Adams JM; Hewitt RG; Steinwandel C; DeRemer M; Cousins S; Morse GD; Antiviral Clinical Pharmacology Unit Immunodeficiency Services, Erie; County Medical Center, Buffalo, NY 14215, USA.; STUDY OBJECTIVE: To determine the effect of spontaneous gastric hypoacidity on the pharmacokinetics of zidovudine and didanosine in subjects infected with the human immunodeficiency virus (HIV). DESIGN: Controlled, open-label, single-dose, pharmacokinetic study. SUBJECTS: Thirty-two asymptomatic HIV-infected subjects.
Analysis of the structure of chemically synthesized HIV-1 protease complexed with a hexapeptide inhibitor. Part I: Crystallographic refinement of 2 A data.: Proteins. 1997 Feb;27(2):184-94. Unique Identifier : AIDSLINE MED/97215429; Miller M; Geller M; Gribskov M; Kent SB; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research; Facility and Development Center, MD 21702, USA.; The structure of a complex between a hexapeptide-based inhibitor, MVT-101, and the chemically synthesized (Aba 67,95,167,195; Aba: L-alpha-amino-n-butyric acid) protease from the human immunodeficiency virus (HIV-1), reported previously at 2.3 A has now been refined to a crystallographic R factor of 15.4% at 2.0 A res
Analysis of the structure of HIV-1 protease complexed with a hexapeptide inhibitor. Part II: Molecular dynamic studies of the active site region.: Proteins. 1997 Feb;27(2):195-203. Unique Identifier : AIDSLINE MED/97215430; Geller M; Miller M; Swanson SM; Maizel J; Laboratory of Mathematical Biology, NCI-Frederick Cancer Research; Facility and Development Center, MD 21702, USA.; Six models of the catalytic site of HIV-1 protease complexed with a reduced peptide inhibitor, MVT-101, were investigated. These studies focused on the details of protonation of the active site, its total net charge and hydrogen bonding pattern, which was consistent with both the observed coplanar configuration of the
Pre-existence and emergence of drug resistance in HIV-1 infection.: Proc R Soc Lond B Biol Sci. 1997 May 22;264(1382):631-7. Unique Identifier : AIDSLINE MED/97321832; Bonhoeffer S; Nowak MA; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Department of Zoology, University of Oxford, UK.; seb@newton.zoo.ox.ac.uk; Antiviral treatment of HIV-1 infection often fails because of the rapid emergence of resistant virus within weeks of the start of therapy. This raises the question of whether resistant viruses pre-exist in drug-naive patients or whether it is produced after the start of therapy. Here we compare the likelihood of pre-e
Human placenta does not Reduce AZT (zidovudine) to 3'-amino-3'-deoxythymidine.: Proc Soc Exp Biol Med. 1997 Jul;215(3):243-7. Unique Identifier : AIDSLINE MED/97351577; Plessinger MA; Boal JH; Miller RK; Department of Obstetrics and Gynecology, University of Rochester,; School of Medicine and Dentistry, New York 14642-8668, USA.; Human placental tissue and human trophoblast cells (JAr) were examined after exposure to the anti-HIV nucleoside analog AZT Zidovudine) for the presence of 3 -amino-3 -deoxythymidine AMT), a toxic catabolite. Placental cells were exposed to 7.6 mM AZT
Relationship between hardiness and risk of burnout in a sample of 92 nurses working in oncology and AIDS wards.: Psychother Psychosom. 1997;66(2):78-82. Unique Identifier : AIDSLINE MED/97251656; Costantini A; Solano L; Di Napoli R; Bosco A; Dipartimento di Salute Mentale, Ospedale Forlanini, Universita di Roma; La Sapienza, Italia.; BACKGROUND: The present study tested the hypothesis that particular personality dispositions act as resistance resources in the encounter with stressful life events. METHODS: The sample consisted of 100 student nurses working in critical areas oncology and AIDS). At the beginning of the 2nd year course subjects were a
Puerto Rican youth in drug treatment facilities: who volunteers for HIV testing?: P R Health Sci J. 1997 Mar;16(1):37-44. Unique Identifier : AIDSLINE MED/97304115; Velez CN; Rodriguez LA; Schoenbaum E; Ungemack JA; Department of Biostatistics and Epidemiology, Graduate School of; Public Health, University of Puerto Rico 00936-5067, USA.; This paper examines the characteristics of youngsters in drug treatment who volunteer for AIDS testing in comparison to those who do not. HIV Antibodies testing was offered on a voluntary basis to a sample of 250 Puerto Rican youngsters enrolled in three ambulatory drug treatment centers in 1991. Sixty-six percent of
[Academic responsibility for public policy on health]: P R Health Sci J. 1997 Mar;16(1):57-62. Unique Identifier : AIDSLINE MED/97304119; Firpo-Betancourt A; Recinto de Ciencias Medicas, Universidad de Puerto Rico, Rio Piedras,; USA.
Survival and quality of life in HIV-positive patients treated with a polyantigenic immunomodulator.: P R Health Sci J. 1997 Mar;16(1):9-14. Unique Identifier : AIDSLINE MED/97304112; Colon JI; Encarnacion G; Ortiz Santini MR; Rodriguez Malave MT; Santiago Delpin EA; Marchand AM; Department of Pathology, University of Puerto Rico Medical School, San; Juan 00936-5067, USA.; A polyantigenic immunomodulator (PAI), previously known as polyantigenic vaccine, which consists of a mixture of antigens of inactivated bacteria with antigens of influenza virus in a peanut-oil-arlacel-A-aluminium monoesterate emulsion, increased tumor resistance and induced tumor regression in tumor bearing mice. Th
Reversible cystic disease associated with pulmonary tuberculosis: radiologic findings.: Radiology. 1997 Jul;204(1):165-9. Unique Identifier : AIDSLINE MED/97349236; Ko KS; Lee KS; Kim Y; Kim SJ; Kwon OJ; Kim JS; Department of Diagnostic Radiology, Kwangju Christian Hospital, South; Korea.; PURPOSE: The authors describe radiologic findings of cystic lung disease associated with pulmonary tuberculosis. MATERIALS AND METHODS: Three immunocompetent women with pulmonary tuberculosis were seen with acute respiratory failure and diffuse bilateral pulmonary opacity depicted at admission chest radiography. The w
Mycobacterium kansasii pulmonary infection in patients with AIDS: spectrum of chest radiographic findings.: Radiology. 1997 Jul;204(1):171-5. Unique Identifier : AIDSLINE MED/97349237; Fishman JE; Schwartz DS; Sais GJ; Department of Radiology, University of Miami School of Medicine,; Jackson Memorial Hospital, FL 33136, USA.; PURPOSE: To determine the chest radiographic findings and clinical manifestations of Mycobacterium kansasii pulmonary infection in patients with acquired immunodeficiency syndrome AIDS). MATERIALS AND METHODS: Criteria for diagnosis included two or more positive cultures from respiratory sources, pulmonary symptoms or
[Cost-effective approach to the screening of HIV, HBV, HCV, HTLV in blood donors in France]: Rev Epidemiol Sante Publique. 1997 Apr;45(2):131-41. Unique Identifier : AIDSLINE MED/97309808; Sailly JC; Lebrun T; Coudeville L; CRESGE, Lille.; In order to provide greater safety in blood transfusions, public health authorities have imposed the use of screening tests. The purpose of this paper is to estimate the cost-effectiveness ratios of the screening test used in France . Four risks were studied: HIV, HBV, HCV and HTLV.
[Tuberculin test, antitubercular chemoprophylaxis and incidence of tuberculosis in a Swiss HIV cohort study (news)]: Rev Epidemiol Sante Publique. 1997 Apr;45(2):171-3. Unique Identifier : AIDSLINE MED/97309812; Sudre P; Rieder H; Bassetti S; Hirschel B; Ledergerber B; Malvy D
Noninfectious branch retinal vein occlusion in HIV-positive patients.: Retina. 1997;17(2):162-4. Unique Identifier : AIDSLINE MED/97287985; Park KL; Marx JL; Lopez PF; Rao NA; Doheny Eye Institute, University of Southern California School of; Medicine, Los Angeles, USA.
Major blinding complication of acquired immune deficiency syndrome (AIDS) [letter]: Retina. 1997;17(2):167-8. Unique Identifier : AIDSLINE MED/97287988; Akduman L; Arribas JR; Del Priore LV; Kaplan HJ; Powderly WG
Power considerations for clinical trials using multivariate time-to-event data.: Stat Med. 1997 Apr 30;16(8):865-82. Unique Identifier : AIDSLINE MED/97304212; Hughes MD; Department of Biostatistics, Harvard School of Public Health, Boston,; MA 02115, USA.; Many clinical trials involve the collection of data on the times to occurrence of different types of events, such as different fungal infections in AIDS research, or of recurrences of the same type, such as successive fits in epilepsy research. The multivariate proportional hazards model allows for analysis of this da
Non-parametric inference for cumulative incidence functions in competing risks studies.: Stat Med. 1997 Apr 30;16(8):901-10. Unique Identifier : AIDSLINE MED/97304214; Lin DY; Department of Biostatistics, University of Washington, Seattle 98195,; USA.; In the competing risks problem, a useful quantity is the cumulative incidence function, which is the probability of occurrence by time t for a particular type of failure in the presence of other risks. The estimator of this function as given by Kalbfleisch and Prentice is consistent, and, properly normalized, converge
Use of the Wei-Lin-Weissfeld method for the analysis of a recurring and a terminating event.: Stat Med. 1997 Apr 30;16(8):925-40. Unique Identifier : AIDSLINE MED/97304216; Li QH; Lagakos SW; Department of Biostatistics, Harvard School of Public Health, Boston,; MA 02115, USA.; We consider application of the Wei-Lin-Weissfeld (WLW) method for multiple failure time data when analysing a disease process consisting of a recurring outcome, such as clinical progression, and a terminating outcome, such as death. In order to adapt WLW for this situation, events must be specified that define multi
Analysis of multiple failure time data from an AIDS clinical trial.: Stat Med. 1997 Apr 30;16(8):951-61. Unique Identifier : AIDSLINE MED/97304218; Finkelstein DM; Schoenfeld DA; Stamenovic E; Biostatistics Department, Harvard School of Public Health, Boston, MA; 02115, USA.; The primary endpoint of AIDS prophylaxis trials is the occurrence of opportunistic infections. While the treatments are not expected to have an effect on the underlying HIV disease, an effect of treatments on mortality cannot be ruled out. Therefore, the primary analysis of these trials must be based on a combined end
[Mechanism of HIV infection (news)]: Schweiz Rundsch Med Prax. 1997 Apr 23;86(17):692, 699. Unique Identifier : AIDSLINE MED/97363414
[Drugs active against retroviruses]: Rev Prat. 1997 Mar 15;47(6):631-8. Unique Identifier : AIDSLINE MED/97327150; Brun-Vezinet F; Descamps D; Laboratoire de virologie, Hopital Bichat-Claude-Bernard, Paris.; Major advances in understanding the pathogenesis and treatment of human immunodeficiency virus (HIV) infection have been made recently. The reverse transcriptase and protease enzymes of HIV are currently the targets of antiretroviral therapy. Nucleoside analogues were the first class of antiretroviral drugs which demo
Human herpes virus-8 DNA in bronchoalveolar lavage samples from patients with AIDS-associated pulmonary Kaposi's sarcoma.: Scand J Infect Dis. 1997;29(1):13-6. Unique Identifier : AIDSLINE MED/97266535; Benfield TL; Dodt KK; Lundgren JD; Department of Infectious Diseases, Hvidovre Hospital, University of; Copenhagen, Denmark.; Kaposi s sarcoma (KS) is the most frequent AIDS-associated neoplasm, and often disseminates to visceral organs, including the lungs. An ante-mortem diagnosis of pulmonary KS is difficult. Recently, DNA sequences resembling a new human herpes virus HHV-8), have been identified in various forms of KS. We hypothesized th
Genotype, viral load and age as independent predictors of treatment outcome of interferon-alpha 2a treatment in patients with chronic hepatitis C. Construct group.: Scand J Infect Dis. 1997;29(1):17-22. Unique Identifier : AIDSLINE MED/97266536; Bell H; Hellum K; Harthug S; Maeland A; Ritland S; Myrvang B; von der Lippe B; Raknerud N; Skaug K; Gutigard BG; Skjaerven R; Prescott LE; Simmonds P; Department of Medicine, Aker University Hospital, Oslo, Norway.; Patients with chronic hepatitis C respond differently when treated with interferon. We randomized 116 patients with chronic hepatitis C in order to compare two dosage regimens of recombinant interferon alpha 2a:3 MIU x 3 per week for 6 months arm A) or 6 MIU x 3 per week for 3 months and then 3 MIU x 3 per week for 3
Kaposi's sarcoma and its management in AIDS patients. Recommendations from a Scandinavian Study Group.: Scand J Infect Dis. 1997;29(1):3-12. Unique Identifier : AIDSLINE MED/97266534; KS is the most frequent malignancy in homo/bisexual male AIDS patients, affecting more than 30% of these patients. KS may present itself as a few innocent cutaneous lesions or may show progression resulting in severe morbidity and mortality. Approximately half of the patients may develop severe progressive disease. Th
Cryptococcosis in Denmark: an analysis of 28 cases in 1988-1993.: Scand J Infect Dis. 1997;29(1):51-5. Unique Identifier : AIDSLINE MED/97266542; Knudsen JD; Jensen L; Sorensen TL; Jensen T; Kjersem H; Stenderup J; Pedersen C; Division of Microbiology, Statens Serum Institut, Copenhagen, Denmark.; A total number of 31 events of systemic cryptococcal infection in 28 patients was identified in a nation-wide survey over 6 years from 1988 to the end of 1993. All medical records were reviewed, 24 of the patients were HIV-infected. Meningitis was diagnosed in 25 patients, and fungemia in 8 patients. The most frequent
Features and outcome of Pneumocystis carinii pneumonia according to risk category for HIV infection.: Scand J Infect Dis. 1997;29(1):57-61. Unique Identifier : AIDSLINE MED/97266543; Laing R; Brettle R; Leen C; Hulks G; Infection Unit, Aberdeen Royal Infirmary, UK.; A retrospective study of Pneumocystis carinii pneumonia (PCP) was undertaken to examine differences between the presentation and outcome of PCP in AIDS patients from different risk categories for HIV infection. There were 176 PCP episodes recorded in 126 patients from the following risk categories: 69 intravenous drug
No evidence of nosocomial Pneumocystis carinii infection via health care personnel.: Scand J Infect Dis. 1997;29(1):63-4. Unique Identifier : AIDSLINE MED/97266544; Lidman C; Olsson M; Bjorkman A; Elvin K; Department of Infectious Diseases, University Hospital Huddinge,; Sweden.; Clusters of Pneumocystis carinii pneumonia (PCP) in immunocompromised settings suggest person-to-person transmission. We examined whether personnel in a ward for HIV-infected patients were carriers of P. carinii. None of 29 sputum samples from 19 personnel caring for HIV-infected patients had detectable amounts of P.
Curtailing the AIDS pandemic [letter]: Science. 1997 Jun 27;276(5321):1955-7. Unique Identifier : AIDSLINE MED/97361565; Mullins JI
Firefly gene lights up lab animals from inside out [news]: Science. 1997 Jun 27;276(5321):1993. Unique Identifier : AIDSLINE MED/97361581; Taubes G
Selection for survival? [comment]: Science. 1997 Jun 27;276(5321):2000-1. Unique Identifier : AIDSLINE MED/97361583; Benoist C; Mathis D; Institut de Genetique et de Biologie Moleculaire et Cellulaire INSERM,; CNRS, ULP), 1 rue Laurent Fries, 6704 Illkirch, C.U. de Strasbourg,; France. cb@titus.u-strasbg.fr
An animal model for acute and persistent Epstein-Barr virus infection.: Science. 1997 Jun 27;276(5321):2030-3. Unique Identifier : AIDSLINE MED/97342848; Moghaddam A; Rosenzweig M; Lee-Parritz D; Annis B; Johnson RP; Wang F; Department of Medicine, Brigham and Women's Hospital, Harvard Medical; School, 181 Longwood Avenue, Boston, MA 02115, USA.; Epstein-Barr virus (EBV) is a human lymphocryptovirus that causes infectious mononucleosis, persists asymptomatically for life in nearly all adults, and is associated with the development of B cell lymphomas and nasopharyngeal carcinomas. A highly similar rhesus lymphocryptovirus naturally endemic in rhesus monkeys wa
Differential requirements for survival and proliferation of CD8 naive or memory T cells [see comments]: Science. 1997 Jun 27;276(5321):2057-62. Unique Identifier : AIDSLINE MED/97342857; Tanchot C; Lemonnier FA; Perarnau B; Freitas AA; Rocha B; INSERM U345, Institut Necker, 156 Rue Vaugirard, 75015 Paris, France.; The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naive and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen. Naive T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, t
The role of type I interferons in the differentiation and function of Th1 and Th2 cells.: Semin Oncol. 1997 Jun;24(3 Suppl 9):S9-94-S9-98. Unique Identifier : AIDSLINE MED/97352483; de Waal Malefyt R; Department of Immunobiology, DNAX Research Institute, Palo Alto, CA; 94304-1104, USA.; T-helper cells are compartmentalized according to the cytokines they are able to produce. T-helper 1 cells produce interleukin-2 IL-2 ) and interferon-gamma (IFN-gamma), and develop following priming with IL-12. T-helper 2 cells produce IL-4, IL-5, and IL-10, and IL-4 i
[Clinical medicine of 21st century and rheumatology]: Ryumachi. 1997 Apr;37(2):151. Unique Identifier : AIDSLINE MED/97357027; Shiokawa Y
[Case of the month]: Ther Umsch. 1997 Apr;54(4):209-10. Unique Identifier : AIDSLINE MED/97275624; Buchmann P; Chirurgische Klinik, Stadtspital Waid, Zurich.
Efficient myoblast transplantation in mice immunosuppressed with monoclonal antibodies and CTLA4 Ig.: Transplant Proc. 1997 Jun;29(4):1932-4. Unique Identifier : AIDSLINE MED/97336713; Guerette B; Wood K; Roy R; Tremblay JP; Neurobiology Research Center, Laval University, Quebec, Canada.
Ex vivo replicative potential of adult human peripheral blood CD4+ T cells.: Transplant Proc. 1997 Jun;29(4):2028. Unique Identifier : AIDSLINE MED/97336764; Levine BL; Bernstein W; Craighead N; Thompson CB; Lindsten T; St Louis DC; June CH; Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA.
NK cells, macrophages, and humoral immune responses are dominant in primary nonfunction of islet grafts in the dog-to-rat xenotransplant model.: Transplant Proc. 1997 Jun;29(4):2062-3. Unique Identifier : AIDSLINE MED/97336780; Deng S; Ketchum RJ; Kucher T; Weber M; Naji A; Brayman KL; Department of Surgery, University of Pennsylvania Medical Center,; Philadelphia 19104, USA.
T-helper 1 and 2 activation with fresh or cultured allo- or xenoislets.: Transplant Proc. 1997 Jun;29(4):2257-8. Unique Identifier : AIDSLINE MED/97336867; Giannarelli R; Marchetti P; Tellini C; Ferdeghini M; Arvia C; Prontera C; Del Guerra S; Lupi R; Coppelli A; Navalesi R; Cattedra Malattie del Metabolismo, Universita di Pisa, Italy.
Replacement of posttranscriptional regulation in SIVmac239 generated a Rev-independent infectious virus able to propagate in rhesus peripheral blood mononuclear cells.: Virology. 1997 Jun 9;232(2):291-9. Unique Identifier : AIDSLINE MED/97335176; von Gegerfelt A; Felber BK; ABL-Basic Research Program, National Cancer Institute-Frederick Cancer; Research and Development Center, Maryland 21702-1201, USA.; Lentiviruses control virion production via posttranscriptional regulation mediated by the viral Rev protein. In this study, we demonstrate that the Rev regulation of SIVmac239 can be replaced by the presence of the cis-acting transport element (CTE) of the type D simian retroviruses 1 (SRV-1). To avoid the possibility
Activity of human immunodeficiency virus type 1 promoter/TAR regions and tat1 genes derived from individuals with different rates of disease progression.: Virology. 1997 Jun 9;232(2):319-31. Unique Identifier : AIDSLINE MED/97335179; Kirchhoff F; Greenough TC; Hamacher M; Sullivan JL; Desrosiers RC; Institute for Clinical and Molecular Virology, Friedrich-Alexander; University, Erlangen, Germany. fkkirchh@viro.med.uni-erlangen.de; Different rates of disease progression may be associated with different human immunodeficiency virus type 1 (HIV-1) promoter and/or transactivator activities. We therefore analyzed the sequences and activities of the first exon of Tat, tat1, and the promoter/trans-acting responsive (TAR) regions amplified directly fro
The long terminal repeats of human immunodeficiency virus type-1 and human T-cell leukemia virus type-I are activated by 12-O-tetradecanoylphorbol-13-acetate through different pathways.: Virology. 1997 Jun 9;232(2):337-44. Unique Identifier : AIDSLINE MED/97335181; Mor-Vaknin N; Torgeman A; Galron D; Lochelt M; Flugel RM; Aboud M; Department of Microbiology and Immunology, Faculty of Health Sciences,; Ben Gurion University of the Negev, Beer Sheve, Israel.; The LTRs of HIV-1 and HTLV-I have been shown by several laboratories to be activated by 12-O-tetradecanoylphorbol-13-acetate (TPA). This agent is a potent activator of protein kinase C (PKC). However, long exposure to TPA downregulates PKC in many cell types. We demonstrated that TPA treatment of Jurkat cells for more
Cell proliferation is not required for productive HIV-1 infection of macrophages.: Virology. 1997 Jun 9;232(2):379-84. Unique Identifier : AIDSLINE MED/97335186; Schmidtmayerova H; Nuovo GJ; Bukrinsky M; Picower Institute for Medical Research, Manhasset, New York 11030,; USA.; Lentiviruses, including HIV-1, are considered a rare example of retroviruses which do not require cell proliferation for their replication. However, this notion was questioned in several publications where productive HIV-1 infection was found to be restricted to a small fraction of macrophages with proliferative capac
Image segmentation enhances discrimination of motion in visual noise.: Vision Res. 1997 Jun;37(11):1415-27. Unique Identifier : AIDSLINE MED/97349784; Croner LJ; Albright TD; Vision Center Laboratory, Salk Institute, La Jolla, CA 92037, USA.; croner@salk.edu; The primate visual system uses form cues-such as hue, contrast polarity, luminance, and texture-to segment complex retinal images into the constituent objects of the visual scene. We investigated whether segmentation of dynamic images on the basis of hue, luminance contrast polarity, or luminance contrast amplitude ai
[The use of high-capacity immunoplates in determining antibodies to the human immunodeficiency virus]: Zh Mikrobiol Epidemiol Immunobiol. 1997 Jan-Feb;(1):18-22. Unique Identifier : AIDSLINE MED/97311908; Lavrinnenko IA; Kostrovskii VG; The action of gas plasma on the sorption characteristics of polystyrene immunoplates is described. The treatment of immunoplates with gas plasma has proved to be a highly effective method for increasing their adsorption capacity and the sensitivity of immunoassay in the determination of antibodies to human immunodefic
[Polynucleotide (DNA) viral vaccines and their safety problems]: Zh Mikrobiol Epidemiol Immunobiol. 1997 Jan-Feb;(1):78-81. Unique Identifier : AIDSLINE MED/97311923; Gendon IuZ
Implications of recent antiviral pharmacology to prevention of occupational HIV transmission in anesthesia clinical practice.: AANA J. 1996 Dec;64(6):525-7. Unique Identifier : AIDSLINE MED/97348848; Griffis CA; UGLA, USA.
HIV risks among homeless men differentiated by cocaine use and psychiatric distress.: Addict Behav. 1997 Mar-Apr;22(2):287-92. Unique Identifier : AIDSLINE MED/97267905; Zanis DA; Cohen E; Meyers K; Cnaan RA; Department of Psychiatry, University of Pennsylvania, Philadelphia,; USA.; This study examined the relationship among cocaine use, psychiatric distress, and HIV risk behaviors of homeless men. A 3 x 2 ANOVA was computed to determine overall mean HIV risk behavior, with the first factor representing three levels of psychiatric distress (low, moderate, and high) and the second factor represent
Western blot analysis of the reactivity between envelope proteins of hepatitis B viruses from Brazilian carriers and antibodies raised against recombinant hepatitis B vaccines.: Acta Virol. 1996 Nov-Dec;40(5-6):251-8. Unique Identifier : AIDSLINE MED/97315278; De Castro L; Yoshida CF; Gaspar AM; Gomes SA; Department of Virology, Oswaldo Cruz Foundation, Rio de Janeiro,; Brazil.; A Western blot assay was standardized to evaluate the antigenic reactivity of hepatitis B virus (HBV) strains circulating in Brazilian population with antibodies raised against recombinant hepatitis B (HB) vaccines. In this assay, HBV envelope proteins from infected human blood were detected by antibodies from rabbits
AIDS-associated membranous nephropathy with advanced renal failure: response to prednisone.: Am J Kidney Dis. 1997 Jul;30(1):116-9. Unique Identifier : AIDSLINE MED/97357059; Mattana J; Siegal FP; Schwarzwald E; Molho L; Sankaran RT; Gooneratne R; Ahuja TS; Singhal PC; Department of Medicine, Long Island Jewish Medical Center, New Hyde; Park, NY 11040, USA.; We report the case of a patient with acquired immunodeficiency syndrome (AIDS) who developed nephrotic syndrome and progressive renal failure mimicking human immunodeficiency virus HIV)-associated focal segmental glomerulosclerosis (FSGS) who required initiation of hemodialysis and was found on renal biopsy to have me
Prednisone, renal function, and proteinuria in immunodeficiency virus-associated nephropathy.: Am J Kidney Dis. 1997 Jul;30(1):156-9. Unique Identifier : AIDSLINE MED/97357065; Rao TK; Department of Medicine, SUNY Health Services Center at Brooklyn, NY; 11203-2098, USA.
Severity of AIDS and the response to EPO in uremia.: Am J Kidney Dis. 1997 Jul;30(1):28-35. Unique Identifier : AIDSLINE MED/97357047; Ifudu O; Matthew JJ; Mayers JD; Macey LJ; Brezsnyak W; Reydel C; McClendon E; Surgrue T; Rao S; Friedman EA; Department of Medicine, State University of New York Health Science; Center, Brooklyn 11203, USA.; To determine the factors that govern their response to erythropoietin (EPO), we conducted a cross-sectional study of all patients in four outpatient hemodialysis facilities in Brooklyn, NY, who had end-stage renal disease (ESRD) and human immunodeficiency virus (HIV) infection and were receiving recombinant EPO. We al
Secondary prophylaxis for visceral leishmaniasis in HIV-infected individuals [letter; comment]: Am J Med. 1997 Jan;102(1):132. Unique Identifier : AIDSLINE MED/97352958; Perez-Molina JA; Lopez-Velez; Guerrero A
Development and standardization of an immuno-quantified solid phase assay for HIV-1 aspartyl protease activity and its application to the evaluation of inhibitors.: Anal Chem. 1997 May 1;69(9):1746-52. Unique Identifier : AIDSLINE MED/97290371; Fournout S; Roquet F; Salhi SL; Seyer R; Valverde V; Masson JM; Jouin P; Pau B; Nicolas M; Hanin V; Laboratoire d'Immunoanalyse et Innovation en Biologie Clinique, CNRS; UMR 9921, Faculte de Pharmacie, Montpellier, France.; The catELISA technique was modified and standardized for measuring HIV-1 aspartyl protease activity and evaluating the potency of synthetic peptide inhibitors. This immuno-quantified solid phase assay combines the use of an immobilized C-terminal biotinylated peptide as substrate, a crude enzyme preparation, and a hig
HIV, hepatitis B, and hepatitis C in the Code One trauma population.: Am Surg. 1997 Jul;63(7):657-9. Unique Identifier : AIDSLINE MED/97346123; Henein MN; Lloyd L; Department of Surgery, St. John Hospital and Medical Center, Detroit,; Michigan 48236, USA.; The resuscitation of a trauma patient is a very hectic and seemingly chaotic situation. The nature of the situation increases the likelihood that a health care worker will receive an accidental needle stick while caring for the patient. There is also a common belief that there is a higher prevalence of communicable bl
Hyperamylasaemia in asymptomatic HIV patients.: Ann Clin Biochem. 1997 May;34 ( Pt 3):259-62. Unique Identifier : AIDSLINE MED/97302575; Foo Y; Konecny P; Department of Chemical Pathology, Royal Free Hospital, London, UK.; We studied serum amylase and its isoenzymes prospectively in 163 consecutive asymptomatic patients, 149 men and 14 women, infected with HIV and attending an HIV out-patient clinic. Six patients were receiving dideoxyinosine (DDI), a drug known to cause pancreatitis. No patient, however, had clinical signs suggestive o
Postcoital vaginal bleeding as a risk factor for transmission of the human immunodeficiency virus in a heterosexual partner study in Brazil. Rio de Janeiro Heterosexual Study Group.: Arch Intern Med. 1997 Jun 23;157(12):1362-8. Unique Identifier : AIDSLINE MED/97344629; Guimaraes MD; Vlahov D; Castilho EA; Department of Preventive and Social Medicine, Federal University of; Minas Gerais, Belo Horizonte, Brazil.; BACKGROUND: Several risk factors for male-to-female human immunodeficiency virus (HIV) transmission are well established, but few studies have examined the role of postcoital vaginal bleeding. METHODS: Couples recruited from AIDS centers in Rio de Janeiro, Brazil , were interviewed
Tuberculous pericarditis in a woman infected with human immunodeficiency virus type 1, long-term nonprogressive [letter; comment]: Arch Intern Med. 1997 Jun 23;157(12):1391-2. Unique Identifier : AIDSLINE MED/97344635; Buil E; Manso C; Vidal F; Peraire J; Richart C
Colonic histoplasmosis associated with acquired immunodeficiency syndrome [letter]: Arch Intern Med. 1997 Jun 23;157(12):1393. Unique Identifier : AIDSLINE MED/97344637; Warner D
Synthesis and in vitro anti-HIV activity of certain 2-(1H-benzimidazol-2-ylamino)pyrimidin-4(3H)-ones and related derivatives.: Arch Pharm (Weinheim). 1997 Mar;330(3):59-62. Unique Identifier : AIDSLINE MED/97310281; Badawey el-S; Kappe T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy,; University of Alexandria, AR Egypt.; In an ongoing effort to develop novel non-nucleoside human immunodeficiency virus inhibitors, a series of substituted 2-(1H-benzimidazol-2-ylamino)pyrimidin-4(3H)-ones and related derivatives were synthesized via cyclocondensation of 2-ganidino-1H-benzimidazole with diethyl ethoxymethylenemalonate, substituted diethyl
Lymphocytopenia in a hospital population--what does it signify?: Aust N Z J Med. 1997 Apr;27(2):170-4. Unique Identifier : AIDSLINE MED/97290535; Castelino DJ; McNair P; Kay TW; Box Hill Hospital, Melbourne, Vic.; BACKGROUND: Lymphocytopenia is a common finding in hospital patients especially since the advent of automated differential leukocyte counters. The causes and significance of lymphocytopenia are generally poorly understood. There has been no large-scale study of its significance for 25 years. The HIV epidemic, and the
An overview of the Xth International Conference on AIDS/Vth STD World Congress, Yokohama, Japan, 1994 [editorial]: Pediatr AIDS HIV Infect. 1995 Feb;6(1):1-2. Unique Identifier : AIDSLINE MED/97340447
Xth International Conference on AIDS/Vth STD World Congress. Yokohama, Japan, August, 1994. Proceedings and abstracts.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):1-49. Unique Identifier : AIDSLINE MED/97358436
Workshop on pediatric AIDS rehabilitation: a summary.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):14-7. Unique Identifier : AIDSLINE MED/97340449; McCardle P; Quatrano LA; Division of Research Grants, National Institute of Child Health and; Human Development, National Institutes of Health, USA.; The workshop offered the following recommendations for research on pediatric AIDS: (1) investigating cross-cutting issues such as pain and/or QOL; (2) identifying effective service delivery and associated cultural considerations; (3) promoting data sharing and standardized instruments; and (4) examining affected body
Lymphoma presenting as a tumor of the maxillary sinuses in an HIV-infected child.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):18-20. Unique Identifier : AIDSLINE MED/97340450; Campos JM; Simonetti JP; Santos EN; Pone MV; Carvalho LM; Pegado C; Department of Pediatrics (Infectious Disease Division), Fernandes; Figueira Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Oral hairy leukoplakia in two children with perinatally acquired HIV-1 infection.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):21-3. Unique Identifier : AIDSLINE MED/97340451; Mannelli F; Galli L; Ficarra G; Romagnoli P; Vierucci S; de Martino M; Department of Pediatrics, University of Florence, Italy.; We report on two children with acquired immunodeficiency syndrome AIDS), a 5-year-old girl and a 9-year-old boy, who presented with oral hairy leukoplakia (OHL) as a late clinical manifestation of perinatally acquired human immunodeficiency virus type 1 (HIV-1) infection. The reasons why OHL is a rare symptom in HIV-1
Factors predictive of maternal-fetal transmission of HIV-1. Preliminary analysis of zidovudine given during pregnancy and/or delivery.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):24-6. Unique Identifier : AIDSLINE MED/97340452; Morrison JC; Department of Obstetrics, and Gynecology, University of Missouri; Medical Center, Jackson, Mississippi, USA.
Confidentiality in health care: a survey of knowledge, perceptions, and attitudes among high school students.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):26. Unique Identifier : AIDSLINE MED/97340453; Glover JJ; Children's National Medical Center, Washington, D.C., USA.
Pediatric antiretroviral choices.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):26-8. Unique Identifier : AIDSLINE MED/97340454; DePalma L; Department of Hematology, George Washington University, Medical; Center, Washington, D.C. USA.
Early detection of HIV in infants: aspects of design and analysis for diagnostic test studies.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):3-13. Unique Identifier : AIDSLINE MED/97340448; Kozinetz CA; Kline MW; Lewis DE; Hollinger BF; Reuben JM; Rosenblatt H; Hanson IC; Hammill H; Shearer WT; Department of Pediatrics, Baylor College of Medicine, Houston, Texas,; USA.; OBJECTIVE: To review investigations on the early detection of HIV infection in infants to determine adherence to traditional methods of study design and analysis for evaluating new laboratory tests. DATA SOURCES: A National Library of Medicine MEDLINE) search was conducted to identify such investigations through 1993.
HIV and AIDS surveillance statistics--USA. July 1992-June 1994.: Pediatr AIDS HIV Infect. 1995 Feb;6(1):50-9. Unique Identifier : AIDSLINE MED/97340455
Oropharyngeal and esophageal candidiasis in HIV disease: emerging pathogens, changing therapies.: Aids Patient Care STDS. 1997 Feb;11 Suppl 1:S1-25; quiz S26-7. Unique Identifier : AIDSLINE MED/97363396
The diagnosis and treatment of candidiasis: current therapeutic options.: Aids Patient Care STDS. 1997 Feb;11 Suppl 1:S10-4; discussion S15. Unique Identifier : AIDSLINE MED/97211967; Filler SG; UCLA School of Medicine, USA.
Itraconazole oral solution: pharmacokinetics and absorption.: Aids Patient Care STDS. 1997 Feb;11 Suppl 1:S16-7. Unique Identifier : AIDSLINE MED/97211968; Saag M; University of Alabama at Birmingham, USA.
Itraconazole oral solution: clinical review and experience.: Aids Patient Care STDS. 1997 Feb;11 Suppl 1:S18-21. Unique Identifier : AIDSLINE MED/97211969; Kauffman CA; University of Michigan Medical School, Ann Arbor, USA.
Clinical case presentations. Oropharyngeal and esophageal candidiasis in HIV disease.: Aids Patient Care STDS. 1997 Feb;11 Suppl 1:S22-5. Unique Identifier : AIDSLINE MED/97211970
The changing mycology of candidiasis: new and resistant pathogens.: Aids Patient Care STDS. 1997 Feb;11 Suppl 1:S5-8; discussion S9. Unique Identifier : AIDSLINE MED/97211966; Rinaldi MG; Clinical Laboratory Science, University of Texas Health Science; Center, San Antonio, USA.
Monokine-producing cells predominate in the recruitment phase of NOD insulitis while cells producing Th1-type cytokines characterize the effector phase.: J Autoimmun. 1997 Apr;10(2):147-55. Unique Identifier : AIDSLINE MED/97329363; Pilstrom B; Bjork L; Bohme J; Department of Immunology, The Wenner-Gren Institute, Stockholm; University, Sweden.; Cells infiltrating the Langerhans islets of prediabetic NOD females were isolated from 6 weeks to 6 months of age. These cells were assayed at a single-cell level for production of eight different cytokines by intracellular immunofluorescent staining. Quiescent in vivo preactivated cells were detected by in vitro sti
Lactation stage-dependent changes of lymphocyte subpopulations in mammary secretions: inversion of CD4+/CD8+ T cell ratios at parturition.: Am J Reprod Immunol. 1997 May;37(5):378-83. Unique Identifier : AIDSLINE MED/97340297; Yang TJ; Ayoub IA; Rewinski MJ; Department of Pathobiology, University of Connecticut, Storrs; 06269-3089, USA.; PROBLEM: Determination of lactation stage-dependent changes in levels of lymphocyte subpopulations in milk. METHOD: Flow cytometric assay was used to identify and assay lymphocyte subpopulations in bovine milk at different stages of lactation. RESULTS: Lymphocyte subpopulations in mammary secretions of dairy cows chan
Predictors of follow-through on plans to be tested for HIV.: Am J Prev Med. 1997 May-Jun;13(3):193-8. Unique Identifier : AIDSLINE MED/97325138; Phillips KA; Coates TJ; Catania JA; Center for AIDS Prevention Studies, University of California-San; Francisco 94105, USA.; INTRODUCTION: Fewer than 40% of people in the United States with HIV risk factors have been tested. However, almost 40% of untested individuals with HIV risk factors in high AIDS prevalence cities stated in the 1991 National AIDS Behavioral Surveys (NABS) that they (1) planned to be t
Grandma knew which medicines were best [letter]: Br J Gen Pract. 1997 May;47(418):330. Unique Identifier : AIDSLINE MED/97362983; Melvin D; Moore C
Characterization of the pathogenic KU-SHIV model of acquired immunodeficiency syndrome in macaques.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):635-45. Unique Identifier : AIDSLINE MED/97311515; Joag SV; Li Z; Foresman L; Pinson DM; Raghavan R; Zhuge W; Adany I; Wang C; Jia F; Sheffer D; Ranchalis J; Watson A; Narayan O; Marion Merrell Dow Laboratory of Viral Pathogenesis and Department of; Microbiology, University of Kansas Medical Center, Kansas City 66160,; USA.; By animal-to-animal passage in macaques we derived a pathogenic chimeric simian-human immunodeficiency virus (SHIV) that caused CD4+ T cell loss and AIDS in pigtail macaques and used it to inoculate 20 rhesus and pigtail macaques by the intravaginal and intravenous routes. On the basis of the outcome of infection and
Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):647-56. Unique Identifier : AIDSLINE MED/97311516; Li A; Baba TW; Sodroski J; Zolla-Pazner S; Gorny MK; Robinson J; Posner MR; Katinger H; Barbas CF 3rd; Burton DR; Chou TC; Ruprecht RM; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute,; Harvard Medical School, Boston, Massachusetts 02115, USA.; A panel of 14 human IgG monoclonal antibodies (MAbs) specific for envelope antigens of the human immunodeficiency virus type 1 HIV-1), 2 high-titer human anti-HIV-1 immunoglobulin (HIVIG) preparations, and 15 combinations of MAbs or MAb/HIVIG were tested for their ability to neutralize infection of cultured human T ce
Identification of a synthetic peptide that mimics an HIV glycoprotein 120 envelope conformational determinant exposed following ligation of glycoprotein 120 by CD4.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):657-64. Unique Identifier : AIDSLINE MED/97311517; Weinberg J; Liao HX; Torres JV; Matthews TJ; Robinson J; Haynes BF; Department of Medicine, Center for AIDS Research, Duke University; Medical Center, Durham, North Carolina 27710, USA.; CD4 ligation of HIV envelope gp120 results in conformational changes in gp120 that lead to exposure of the gp41 fusogenic domain and fusion with the host cell membrane. One determinant at or near the CD4-binding site exposed on gp120 subsequent to CD4 binding is defined by two human MAbs termed 17b and 48d. These MAbs
Basolateral sorting of the HIV type 2 and SIV envelope glycoproteins in polarized epithelial cells: role of the cytoplasmic domain.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):665-75. Unique Identifier : AIDSLINE MED/97311518; Ball JM; Mulligan MJ; Compans RW; Department of Microbiology, University of Alabama at Birmingham,; 35294, USA.; In polarized epithelial cell lines, enveloped viruses are directionally released by asymmetric viral budding at specific plasma membrane domains. Previous studies have shown that HIV-1 budding and gp160 expression occur on basolateral membranes whereas the release of HIV-1 Gag particles, in the absence of the Env glyc
The in vitro anti-HIV efficacy of negatively charged human serum albumin is antagonized by heparin.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):677-83. Unique Identifier : AIDSLINE MED/97311519; Swart PJ; Sun CS; Kuipers ME; Asuncion C; Josephs S; Smit C; Meijer DK; Groningen Institute for Drug Studies, University Centre for Pharmacy,; Section Pharmacokinetics and Drug Delivery, The Netherlands.; Succinylated human serum albumin (Suc-HSA) was synthesized by treating human serum albumin with succinic anhydride. Among similar proteins and neo(glyco)proteins tested, Suc-HSA exhibits a pronounced net negative charge, a feature that largely contributes to its efficacy against replication of human immunodeficiency v
Analysis of CD8+ T lymphocyte-mediated nonlytic suppression of autologous and heterologous primary human immunodeficiency virus type 1 isolates.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):685-93. Unique Identifier : AIDSLINE MED/97311520; Kootstra NA; Miedema F; Schuitemaker H; Department of Clinical Viro-Immunology, The Netherlands Red Cross; Blood Transfusion Service, University of Amsterdam.; Nonlytic CD8+ T lymphocyte antiviral factor (CAF) activity has been described as having an important role in the clinical course of human immunodeficiency virus type 1 (HIV-1) infection. Testing of CAF activity against autologous viruses isolated at approximately the same time points showed that CD8+ T lymphocytes fro
Tetrahydronaphthalene lignan compounds as potent anti-HIV type 1 agents.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):695-705. Unique Identifier : AIDSLINE MED/97311521; Hara H; Fujihashi T; Sakata T; Kaji A; Kaji H; Department of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia 19104, USA.; Anti-HIV-1 activity of tetrahydronaphthalene (THN) derivatives of lignan compounds was studied. THN derivatives prevented cell death caused by HIV-1 infection in MT-4 cells. They also inhibited giant cell formation by HIV-1 in Sup-T1 cells, and p24 production in HIV-1-infected H9 cells. The 50% effective concentration
Effects of (R)-9-(2-phosphonylmethoxypropyl)adenine monotherapy on chronic SIV infection in macaques.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):707-12. Unique Identifier : AIDSLINE MED/97311522; Tsai CC; Follis KE; Beck TW; Sabo A; Bischofberger N; Dailey PJ; Washington Regional Primate Research Center, Seattle 98195, USA.; (R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA) acts as a reverse transcriptase inhibitor of retroviruses and has been shown to be effective against acute simian immunodeficiency virus (SIV) infection in macaques. To study its efficacy at different stages of infection, we tested PMPA in cynomolgus macaques (Macaca fas
Regression of feline immunodeficiency virus infection.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):713-8. Unique Identifier : AIDSLINE MED/97311523; O'Neil LL; Burkhard MJ; Obert LA; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.; Regression of feline immunodeficiency virus (FIV) infection was observed in seven of nine vertically infected kittens born to two chronically infected mother cats. Both provirus and nonmaternal FIV antibody were detected in all kittens by 4 weeks of age but only three of the seven kittens were positive by blood mononu
DNA sequence analysis of the long terminal repeat of the C subtype of human immunodeficiency virus type 1 from Southern Africa reveals a dichotomy between B subtype and African subtypes on the basis of upstream NF-IL6 motif.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):719-24. Unique Identifier : AIDSLINE MED/97311524; Zacharova V; Becker ML; Zachar V; Ebbesen P; Goustin AS; Center for Molecular Medicine and Genetics, Wayne State University,; Detroit, Michigan 48202, USA.
HIV type 1 subtype E in Russia.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):725-7. Unique Identifier : AIDSLINE MED/97311525; Bobkov A; Cheingsong-Popov R; Selimova L; Ladnaya N; Kazennova E; Kravchenko A; Pokrovsky V; Weber J; The D. I. Ivanovsky Institute of Virology, Moscow, Russia.
RNA and DNA sequence analysis of the nef gene of HIV type 1 strains from the first HIV type 1-infected long-term nonprogressing mother-child pair.: AIDS Res Hum Retroviruses. 1997 May 20;13(8):729-32. Unique Identifier : AIDSLINE MED/97311526; Saksena NK; Ge YC; Wang B; Xiang SH; Ziegler J; Palasanthiran P; Bolton W; Cunningham AL; Center for Virus Research, Westmead Institutes of Health Research,; Westmead Hospital, NSW, Sydney, Australia.
Behavior change communication strategies.: AIDS Educ Prev. 1997 Apr;9(2):111-23. Unique Identifier : AIDSLINE MED/97310898; Aggleton P; Thomas Coram Research Unit, University of London, England.; Appropriate and effective communication is central to the success of interventions to reduce the risk of HIV infection. This paper reviews what has been learned about the nature of communication in the behavior change process. It examines the contexts in which communication occurs, as well as the contribution of commu
HIV counseling for behavior change.: AIDS Educ Prev. 1997 Apr;9(2):125-32. Unique Identifier : AIDSLINE MED/97310899; Grinstead OA; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; The purpose of this paper was to provide a framework for discussion in the working group on HIV Counseling for Behavior Change at the Third USAID HIV/AIDS Prevention Conference. The paper begins with a section defining HIV counseling and describing different types of HIV counseling. Next, points of consensus and contr
Evaluation of HIV/STD prevention, care and support: an update on WHO's approaches.: AIDS Educ Prev. 1997 Apr;9(2):133-45. Unique Identifier : AIDSLINE MED/97310900; Mertens TE; Carael M; Chief of Development of Policy and Programme Evaluation, World Health; Organization, Geneva, Switzerland.; Over the past decade only a limited number of public health initiatives have been subjected to systematic monitoring and evaluation and, in many instances, there is growing pressure to estimate which approaches work best for a given level of inputs in order to allocate resources effectively. However, evaluation is ver
Characteristics of risk-taking behaviors, HIV and AIDS knowledge, and risk perception among young males in southwest China.: AIDS Educ Prev. 1997 Apr;9(2):147-60. Unique Identifier : AIDSLINE MED/97310901; Wu Z; Zhang J; Detels R; Li VC; Cheng H; Duan S; Li Z; Dong L; Huang S; Jia M; Bi X; Department of Epidemiology, UCLA School of Public Health 90095-1772,; USA.; A cross-sectional survey was undertaken to describe risk-taking behaviors and to assess the knowledge and risk perception of HIV and AIDS among young males aged 18 to 29 years in 82 villages in Longchuan, Yunnan, China , in 1994. Information on demographic, behavioral, and drug-using
Risk contexts and risk behaviors in the Euregion Maas-Rhein: the Boule de Neige intervention for AIDS prevention among drug users.: AIDS Educ Prev. 1997 Apr;9(2):161-80. Unique Identifier : AIDSLINE MED/97310902; Franken IH; Kaplan CD; Addiction Research Institute of Erasmus University, Rotterdam, The; Netherlands.; Using targeted sampling, self-reported data of 1,767 drug users in the Euregion Maas-Rhein were collected over 3 years. Forty-two percent of the injection drug users shared syringes with sexual partners and 47.8% with friends. Eighty-one percent of the total sample had sexual contact in the last 6 months, half of whom
Single Thai women's interpersonal communication and mass media reception on AIDS.: AIDS Educ Prev. 1997 Apr;9(2):181-200. Unique Identifier : AIDSLINE MED/97310903; Nishino Y; Schunck M; Thai Ministry of Public Health. yoshil@mail.idt.net; This research examines young unmarried women s ways of talking about AIDS, AIDS prevention, and its relationship to mass media AIDS messages in Thailand . Data were derived from a survey conducted in four districts of Kanchanaburi province. Three hundred ninety-seven unmarried wom
Key molecule found to prolong survival of HIV patients.: Oncology (Huntingt). 1997 May;11(5):679-80. Unique Identifier : AIDSLINE MED/97303470
Radiation therapy for malignancies in the setting of HIV disease.: Oncology (Huntingt). 1997 May;11(5):683-94; discussion 694, 701-2. Unique Identifier : AIDSLINE MED/97303471; Swift PS; University of California, San Francisco, USA.; With the introduction of increasingly effective antiretroviral agents for the management of AIDS, the life expectancy of appropriately treated patients will continue to lengthen as will the length of time during which infected patients amy develop malignancies, both HIV-related and non-HIV-related. The management of s
Viramune, new antiretroviral agent, crosses the blood-brain barrier [news]: Oncology (Huntingt). 1997 May;11(5):741. Unique Identifier : AIDSLINE MED/97303474
HHV-8-positive body-cavity-based lymphoma: a novel lymphoma entity.: Br J Haematol. 1997 Jun;97(3):515-22. Unique Identifier : AIDSLINE MED/97351016; Carbone A; Gaidano G; Division of Pathology, Centro di Riferimento Oncologico, Istituto; Nazionale di Ricovero e Cura, a Carattere Scientifico, Aviano, Italy.
Successful treatment of cerebral aspergillosis with a novel triazole (voriconazole) in a patient with acute leukaemia.: Br J Haematol. 1997 Jun;97(3):663-5. Unique Identifier : AIDSLINE MED/97351042; Schwartz S; Milatovic D; Thiel E; Abteilung fur Hamatologie, Klinikum Benjamin Franklin, Freie; Universitat, Berlin, Germany.; Invasive aspergillosis is an increasing problem in patients with acute leukaemia, bone marrow transplantation, immunosuppression after solid organ transplantation, or acquired immunodeficiency syndrome. Despite available antifungal treatment, the mortality approaches 100% in patients with dissemination of the infectio
The thiocarboxanilide nonnucleoside UC781 is a tight-binding inhibitor of HIV-1 reverse transcriptase.: Biochemistry. 1997 Jun 24;36(25):7786-92. Unique Identifier : AIDSLINE MED/97352634; Barnard J; Borkow G; Parniak MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, McGill AIDS Centre, McGill University,; Montreal, Quebec, Canada.; The thiocarboxanilide nonnucleoside inhibitor (NNI) UC781 inhibited HIV-1 reverse transcriptase (RT) DNA polymerase activity at a 1:1 molar ratio of inhibitor to enzyme. Inhibition was linear uncompetitive with respect to template/primer (T/P) and mixed noncompetitive with respect to deoxynucleoside triphosphate (dNTP
A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression.: Biochimie. 1996;78(11-12):1075-80. Unique Identifier : AIDSLINE MED/97295245; Kimura T; Hashimoto I; Nishikawa M; Fujisawa JI; Department of Microbiology, Kansai Medical University, Osaka, Japan.; Human immunodeficiency virus type-1 (HIV-1) Rev acts by inducing the specific nucleocytoplasmic transport of a class of incompletely spliced RNAs that encodes the viral structural proteins. The transfection of HeLa cells with a rev-defective HIV-1 expression plasmid, however, resulted in the export of overexpressed, i
The post-transcriptional regulator Rev of HIV: implications for its interaction with the nucleolar protein B23.: Biochimie. 1996;78(11-12):1081-6. Unique Identifier : AIDSLINE MED/97295246; Miyazaki Y; Nosaka T; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.; Human T cell leukemia virus type 1 (HTLV-1) and human immunodeficiency virus type 1 (HIV-1) belong to the complex retrovirus whose replication is controlled by trans-acting proteins. HIV-1 encodes several regulatory proteins, including two essential trans-activations for viral replication, Rev and Tat. Both Rev and Ta
Structural and functional evidence that initiation and elongation of HIV-1 reverse transcription are distinct processes.: Biochimie. 1996;78(11-12):1087-96. Unique Identifier : AIDSLINE MED/97295247; Lanchy JM; Isel C; Ehresmann C; Marquet R; Ehresmann B; UPR 9002 du CNRS, Institut de Biologie Moleculaire et Cellulaire,; Strasbourg, France.; Retroviral reverse transcription starts with the extension of a cellular tRNA primer bound near the 5 end of the viral genomic RNA at a site called the primer binding site (PBS). Formation of the HIV-1 initiation complex between tRNA3(Lys), viral RNA and reverse transcriptase probably occurs during encapsidation of t
Complementary AIDS therapies: the good, the bad and the ugly [editorial]: Int J STD AIDS. 1997 May;8(5):281-5. Unique Identifier : AIDSLINE MED/97318711; Ernst E; HIV-infected/AIDS patients seem to frequently use complementary therapies, yet definitive information in this area is difficult to obtain. The aim of this systematic review is therefore to assess the published data on the use of complementary medicine by HIV-infected/AIDS patients. A computerized systematic literature
Management of HIV-related diarrhoea.: Int J STD AIDS. 1997 May;8(5):286-96; quiz 296-7. Unique Identifier : AIDSLINE MED/97318712; Neild PJ; Nelson MR; St Stephen's Clinic, Chelsea and Westminster Hospital, London, UK.
Azithromycin and erythromycin resistant Neisseria gonorrhoeae following treatment with azithromycin.: Int J STD AIDS. 1997 May;8(5):299-302. Unique Identifier : AIDSLINE MED/97318713; Young H; Moyes A; McMillan A; Department of Medical Microbiology, Edinburgh University Medical; School, UK.; A pre-treatment and a 3-week post-treatment isolate of Neisseria gonorrhoeae from a 13-year-old boy treated with azithromycin in a single 1 g oral dose were characterized microbiologically. Both isolates were of the same serovar/auxotype (1B6/non-requiring) and had similar antibiograms apart from erythromycin and azit
Prevalence of sexual dysfunction in heterosexual patients attending a central London genitourinary medicine clinic.: Int J STD AIDS. 1997 May;8(5):303-6. Unique Identifier : AIDSLINE MED/97318714; Goldmeier D; Keane FE; Carter P; Hessman A; Harris JR; Renton A; Department of Genitourinary Medicine, St Mary's Hospital, London, UK.; Our objective was to determine the prevalence of sexual dysfunction among new heterosexual attendees at a central London genitourinary medicine (GUM) clinic. We carried out a cross-sectional study in which patients completed a self-administered questionnaire-the Golombok-Rust Inventory of Sexual Satisfaction (GRISS) a
Suppression of HIV replication in vitro by CD8+ T-cells from HIV-infected and HIV-seronegative individuals.: Int J STD AIDS. 1997 May;8(5):307-10. Unique Identifier : AIDSLINE MED/97318715; Tsuchie H; Detorio MA; Hossain MM; Tesfamariam N; Trickett A; Lam-Po-Tang PR; Yamada O; Ichimura H; Dwyer JM; Kurimura T; Research Institute for Microbial Diseases, Osaka University, Suita,; Japan.; The inhibitory effect of CD8+ T-cells from HIV-infected or HIV-seronegative individuals on HIV replication in the naturally-infected CD4+ T-cells in vitro was examined. Not only autologous CD8+ T-cells from HIV-infected individuals but also allogeneic CD8+ T-cells from HIV-seronegative individuals prevented or delayed
Gonorrhoea in Coventry 1991-1994: epidemiology, coinfection and evaluation of partner notification in the STD clinic.: Int J STD AIDS. 1997 May;8(5):311-6. Unique Identifier : AIDSLINE MED/97318716; David LM; Wade AA; Natin D; Radcliffe KW; Department of Genitourinary Medicine, Coventry and Warwickshire; Hospital, Birmingham, UK.; The aim of this study is to analyse the epidemiology of gonorrhoea in the Coventry area between 1991-1994 and the implementation and outcome of partner notification. A total of 404 episodes in 382 patients comprised the study group. In Coventry, 97% of episodes were managed in the STD clinic. There was a decrease in f
HIV seroprevalence amongst pregnant women in northeastern Zaire.: Int J STD AIDS. 1997 May;8(5):317-9. Unique Identifier : AIDSLINE MED/97318717; Wannan GJ; Cutting WA; Fischer PR; University of Edinburgh, UK.; To assess the seroprevalence of HIV in pregnant women in northeastern Zaire and factors that correlate with seropositivity, sequential blood sampling and interviews were performed on 700 women at antenatal clinics in northeastern Zaire. The seroprevalence of the 3 clinics surveyed
Case management and patient reactions: a study of STD care in a province in Zambia.: Int J STD AIDS. 1997 May;8(5):320-8. Unique Identifier : AIDSLINE MED/97318718; Hanson S; Engvall J; Sunkutu RM; Kamanga J; Mushanga M; Hojer B; Department of International Health and Social Medicine, Karolinska; Institutet, Stockholm, Sweden.; Sexually transmitted disease (STD) case management was evaluated through observation and interviews at 2 urban and 4 rural health centres and 2 district hospital STD clinics in one urban and 2 rural districts in Central Province, Zambia . The analysis was limited to 59 patients (42
Silent upper genital tract chlamydial infection and disease in women.: Int J STD AIDS. 1997 May;8(5):329-31. Unique Identifier : AIDSLINE MED/97318719; Tait I