1997

Reframing women's risk: social inequalities and HIV infection.: Annu Rev Public Health. 1997;18:401-36. Unique Identifier : AIDSLINE MED/97288774; Zierler S; Krieger N; Department of Community Health, Brown University School of Medicine,; Providence, Rhode Island 02912, USA. sally_zierler@brown.edu; Social inequalities lie at the heart of risk of HIV infection among women in the United States . As of December, 1995, 71,818 US women had developed AIDS-defining diagnoses. These women have been disproportionately poor, African-American, and Latina. Their neighborhoods have been burden
Down-regulation of cell-surface CD4 co-receptor expression and modulation of experimental allergic encephalomyelitis.: Int Immunol. 1997 Apr;9(4):541-5. Unique Identifier : AIDSLINE MED/97283938; Fiori P; Ristori G; Cacciani A; Buttinelli C; Falcone M; Giovanni SD; Montesperelli C; Pozzilli C; Salvetti M; Department of Neurological Sciences, University of Rome La Sapienza,; Italy.; Pre-immunization with autoantigens confers resistance in experimental models of autoimmune diseases. Since non-self molecules can also be protective, it is conceivable that part of the effect rests on a non-specific attenuation of the immune response. This study is aimed at identifying mechanisms by which pre-immuniza
The use of CD4 and CD8 knockout mice to study the role of T-cell subsets in allotransplant rejection.: J Heart Lung Transplant. 1997 Mar;16(3):263-7. Unique Identifier : AIDSLINE MED/97242888; Krieger NR; Fathman CG; Department of Medicine, Stanford University School of Medicine, Calif.; 94305-5111, USA.
[Pentoxifylline and oral aphthosis in patients with HIV infection letter)]: An Med Interna. 1997 Feb;14(2):102. Unique Identifier : AIDSLINE MED/97269434; Blanch Falp J; Garcia Pont X; Torne Cachot J; Moner Coromina L; Baucells Azcona JM
[Home care for the terminally ill HIV patient]: An Med Interna. 1997 Feb;14(2):93-7. Unique Identifier : AIDSLINE MED/97269431; Bascunana Morejon de Giron J; Sanz de Barros R; de la Pena Gonzalez M; Candel Monserrate I; Servicio de Medicina Interna II, Hospital Universitario San Carlos,; Madrid.; Until now, the care of HIV patients, essentially were in the hospital; but the increase in the number of this and the news aspects of them have conditioned changes in the form of assistance. The primary assistance of this patients include prevention, precocious diagnostics, control of assymptomatics patients and diagn
Neurologic manifestations in human immunodeficiency virus infection/acquired immunodeficiency syndrome [editorial; comment]: Intern Med. 1997 Mar;36(3):160-1. Unique Identifier : AIDSLINE MED/97289081; Kimura S
Serum levels of soluble Fas/APO-1 receptor in human retroviral infection and associated diseases.: Intern Med. 1997 Mar;36(3):166-70. Unique Identifier : AIDSLINE MED/97289083; Kamihira S; Yamada Y; Hiragata Y; Yamaguchi T; Izumikawa K; Matsuo Y; Sugahara K; Tsuruta K; Atogami S; Tsukasaki K; Maeda T; Tomonaga M; Department of Laboratory Medicine, Nagasaki University School of; Medicine.; Fas/APO-1 mediates apoptosis via Fas and Fas ligand transduction. Recently, a soluble form of Fas (sFas) was described which seems to be functionally implicated in the Fas signal system, suggesting a relationship between some disorders and sFas function. We measured sFas-levels in sera from normal controls and patient
Nationwide survey of neurologic manifestations of acquired immunodeficiency syndrome in Japan [see comments]: Intern Med. 1997 Mar;36(3):175-8. Unique Identifier : AIDSLINE MED/97289085; Nakagawa M; Maruyama Y; Sugita H; Osame M; Third Department of Internal Medicine, Kagoshima University School of; Medicine.; To study the epidemiology of the neurologic manifestations of human immunodeficiency virus (HIV)-1 infection in Japan , we conducted two nationwide surveys. Of 1854 HIV-1 carriers, 578 had acquired immunodeficiency syndrome (AIDS) and 166 (28.7% of AIDS patients) had neurologic manif
[HIV and pregnancy: risks of transmission and therapeutic possibilities]: Gynakol Geburtshilfliche Rundsch. 1996;36(4):188-93. Unique Identifier : AIDSLINE MED/97290259; Ibe M; Knolle P; Beck T; Meyer zum Buschenfelde KH; Gerken G; Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universitat; Mainz, Deutschland.; In Europe, transmission of HIV-1 during pregnancy occurs in 14% of children born to HIV-infected women. Risk factors for transmission are (1) virus load measured by p-24 antigenemia and HIV RNA level, (2) low CD4+ lymphocyte counts (below 600/microliter, (3) placental membrane inflammation and (4) time interval betwee
Microbiologic and histologic diagnosis of histoplasmosis in Taiwan.: J Formos Med Assoc. 1997 May;96(5):374-8. Unique Identifier : AIDSLINE MED/97314568; Kao TW; Hung CC; Hsueh PR; Lin TY; Chen MY; Luh KT; Chuang CY; Department of Internal Medicine, National Taiwan University Hospital,; Taipei, ROC.; Histoplasmosis is one of the most common opportunistic fungal infections in immunocompromised patients in endemic areas. We report the first two microbiologically documented cases of histoplasmosis in Taiwan . The first patient, with
India protects jobs of people with HIV infection [news]: BMJ. 1997 May 24;314(7093):1505. Unique Identifier : AIDSLINE MED/97326373; Mudur G
A pilot HIV prevention program for adolescents in a psychiatric hospital.: Psychiatr Serv. 1997 Apr;48(4):531-3. Unique Identifier : AIDSLINE MED/97246129; Brown LK; Reynolds LA; Lourie KJ; Rhode Island Hospital, Providence 02903, USA.; In a pilot HIV prevention program for 35 adolescents in a psychiatric hospital, patients completed assessments of their HIV-related knowledge, attitudes, and behaviors before entering the program, at discharge, and three months after discharge. At discharge they showed significant increases in knowledge, tolerance of
Issues in the psychiatric care of Hispanics.: Psychiatr Serv. 1997 Apr;48(4):539-40. Unique Identifier : AIDSLINE MED/97246132; Ruiz P; Department of Psychiatry and Behavioral Sciences, University of; Texas-Houston Helath Science Center, USA.; Factors affecting the mental health care of ethnic minority groups in the United States deserve serious consideration. Hispanics, the second largest of these groups, face problems of access to care, high rates of substance abuse and HIV, and shortages of Hispanic psychiatric profession
[Role of the conformation changement of CD4 in the HIV-cell fusion]: C R Acad Sci III. 1997 Feb;320(2):163-70. Unique Identifier : AIDSLINE MED/97325053; Sanejouand YH; Laboratoire de physique quantique, UMR 5626 du CNRS, IRSAMC,; Universite Paul-Sabatier, Toulouse, France.; It is well known that the gp120-gp41 complex undergoes a conformational change after CD4 binding. It is likely that CD4 undergoes a conformational change as well. Recently, a calculation of the normal modes of the two N-terminal domains of CD4 has shown that a hinge-bending motion of one of these domains with respect
[New strategy for RNA vectorization in mammalian cells. Use of a peptide vector]: C R Acad Sci III. 1997 Apr;320(4):279-87. Unique Identifier : AIDSLINE MED/97326612; Vidal P; Morris MC; Chaloin L; Heitz F; Divita G; Centre de recherches de biochimie macromoleculaire, URS 155 CNRS,; Montpellier, France.; A major barrier for gene delivery is the low permeability of nucleic acids to cellular membranes. The development of antisenses and gene therapy has focused mainly on improving methods of oligonucleotide or gene delivery to the cell. In this report we described a new strategy for RNA cell delivery, based on a short si
National survey of endodontists and selected patient samples: infectious diseases and attitudes toward infection control.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jun;83(6):696-702. Unique Identifier : AIDSLINE MED/97339066; Cohen AS; Jacobsen EL; BeGole EA; University of the Pacific, School of Dentistry, San Francisco, Calif.,; USA.; A survey was conducted of 591 patients from endodontic practices located in six large municipalities in the United States . A comparison was made between the self-reported incidence of transmissible diseases from patients medical histories to national statistics for the incidence of hep
Leishmania and human immunodeficiency virus coinfection: the first 10 years.: Clin Microbiol Rev. 1997 Apr;10(2):298-319. Unique Identifier : AIDSLINE MED/97259656; Alvar J; Canavate C; Gutierrez-Solar B; Jimenez M; Laguna F; Lopez-Velez R; Molina R; Moreno J; Laboratorio de Referencia de Leishmaniasis, Instituto de Salud Carlos; III, Majadahonda, Madrid, Spain.; Over 850 Leishmania-human immunodeficiency virus (HIV) coinfection cases have been recorded, the majority in Europe, where 7 to 17% of HIV-positive individuals with fever have amastigotes, suggesting that Leishmania-infected individuals without symptoms will express symptoms of leishmaniasis if they become immunosuppr
Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection.: Clin Microbiol Rev. 1997 Apr;10(2):358-67. Unique Identifier : AIDSLINE MED/97259659; Weissman D; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-1576, USA. dweissman@nih.gov; The role of dendritic cells (DC) in the pathogenesis of human immunodeficiency virus (HIV) disease has been a subject of considerable interest for several years. Initial studies focused on the infection, dysfunction, and depletion of DC in HIV-infected individuals. More recent studies have begun to identify the functi
Markedly induced asialoGM1+CD8+ T cell production and enhancement of antimetastatic activity by interferon beta with folic or folinic acid.: Cancer Immunol Immunother. 1997 Apr;44(2):65-9. Unique Identifier : AIDSLINE MED/97320615; Iigo M; Moriyama M; Suzuki I; Tsuda H; Chemotherapy Division, National Cancer Center Research Institute,; Chuo-ku, Tokyo, Japan.; Either folic or folinic acid enhanced the antimetastatic activity of recombinant murine interferon beta (rMulFN beta) toward highly metastatic colon carcinoma 26 (Co 26Lu). Folinic acid administered with rMuIFN beta markedly increased asialoGM1+CD4+ and asialoGM1+CD8+ T cell production in the peritoneal cavity but not
Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment.: Cancer Immunol Immunother. 1997 Apr;44(2):77-82. Unique Identifier : AIDSLINE MED/97320617; Belfrage H; Dohlsten M; Hedlund G; Kalland T; Department of Cell and Molecular Biology, Lund University, Sweden.; Injection of the superantigen staphylococcal enterotoxin A (SEA) activates both CD4+ and CD8+ T cells expressing certain families of T cell receptor (TCR) variable-region beta (V beta) chain. T cells respond with profound cytokine production and induction of cytotoxicity. Repeated injections, however, cause deletion a
Cellular characteristics of peripheral blood lymphocytes and tumour-infiltrating lymphocytes in patients with gynaecological tumours.: Cancer Immunol Immunother. 1997 Apr;44(2):88-96. Unique Identifier : AIDSLINE MED/97320619; Schondorf T; Engel H; Lindemann C; Kolhagen H; von Rucker AA; Mallmann P; Department of Gynaecology and Obstetrics, University of Cologne,; Germany.; Immunotherapy of gynaecological cancer with tumour-infiltrating lymphocytes (TIL) or peripheral blood lymphocytes (PBL) has become a valid treatment modality with varying degrees of success in obtaining an antitumour response. TIL consist of lymphocytes, mainly T cells and minor populations of natural killer cells or
Treatment of subcutaneous tumor with adoptively transferred T cells.: Cell Immunol. 1997 May 25;178(1):24-32. Unique Identifier : AIDSLINE MED/97328137; Peng L; Shu S; Krauss JC; Center for Surgery Research, Cleveland Clinic Foundation, Ohio 44195,; USA.; Adoptive immunotherapy with T cells directed at tumor antigens has been demonstrated to result in the regression of malignant tumors in humans. These encouraging results have prompted the further exploration of parameters necessary to treat tumor in various locations in animal models. We have demonstrated that T cells
Inductive events in oral tolerance in the TCR transgenic adoptive transfer model.: Cell Immunol. 1997 May 25;178(1):62-8. Unique Identifier : AIDSLINE MED/97328141; Chen Y; Inobe J; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard; Medical School, Boston, Massachusetts 02115, USA.; Oral administration of antigen induces a systemic hyporesponsiveness termed oral tolerance. High doses of oral antigen lead to deletion or anergy of T-cells whereas low doses induce regulatory T-cells that secrete Th2 cytokines (IL-4/IL-10) and TGF-beta. The initiating events associated with oral tolerance have not be
Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis.: Cell Immunol. 1997 May 25;178(1):69-78. Unique Identifier : AIDSLINE MED/97328142; Xu H; Rizzo LV; Silver PB; Caspi RR; Laboratory of Immunology, NEI, National Institutes of Health,; Bethesda, Maryland 20892, USA.; This study addresses the nature of the pathogenic effector T cell in experimental autoimmune uveoretinitis and the effect of different cytokines on these cells in vitro. Lymph node cells of B10.RIII mice immunized with the uveitogenic peptide 161-180 of interphotoreceptor retinoid binding protein were cultured with th
Circulating CD8 T cells show increased interferon-gamma mRNA expression in HIV infection.: Cell Immunol. 1997 May 25;178(1):91-8. Unique Identifier : AIDSLINE MED/97328144; Breen EC; Salazar-Gonzalez JF; Shen LP; Kolberg JA; Urdea MS; Martinez-Maza O; Fahey JL; Department of Microbiology and Immunology, University of California,; Los Angeles 90095-1747, USA. ebreen@ucla.edu; IFN-gamma mRNA levels were measured in unstimulated PBMC and purified cell subpopulations, utilizing branched DNA assays, to characterize the cell type(s) that contribute to the in vivo increase in IFN-gamma gene expression seen in HIV infection. PBMC and CD8 T cells from HIV-seropositive subjects (HIV+) showed 2.5-fo
Solution conformation of N-terminal fragments of trichosanthin small domain (TCS 182-200). Circular dichroic studies.: J Pept Res. 1997 Feb;49(2):113-9. Unique Identifier : AIDSLINE MED/97292797; Hu HY; Lu ZX; Du YC; Shanghai Institute of Biochemistry, Chinese Academy of Sciences,; People's Republic of China.; Three peptides, T14, T18 and TDK, derived from the N-terminus of trichosanthin small domain (TCS 182-200) have been investigated by circular dichroism. Secondary structure and structural transitions of the above peptides under different conditions were studied. Alcohol prompts a transition of the T18 peptide from a be
Predicting RNA structures: the model of the RNA element binding Rev meets the NMR structure.: Fold Des. 1997;2(2):141-7. Unique Identifier : AIDSLINE MED/97281679; Leclerc F; Srinivasan J; Cedergren R; Departement de biochimie, Universite de Montreal CP, Quebec, Canada.; BACKGROUND: How accurate are the predictions of RNA three-dimensional structures? Assessing this accuracy requires the detailed comparison of the prediction with the experimentally determined structure. Previously, sequence variation in RNA aptamers that bind the Rev protein was used to infer a three-dimensional model
[Possible HIV infection: when exposure prophylaxis? (news)]: Dtsch Med Wochenschr. 1997 May 16;122(20):A7. Unique Identifier : AIDSLINE MED/97329763; Weismann H
Antifungal agents in the 1990s. Current status and future developments.: Drugs. 1997 Apr;53(4):539-49. Unique Identifier : AIDSLINE MED/97253215; Kauffman CA; Carver PL; Department of Internal Medicine, University of Michigan Medical; School, Ann Arbor, USA. ckauff@umich.edu; Significant advances in antifungal therapy have occurred in the last decade. Most of these advances have been tied to the introduction of the triazoles, itraconazole and fluconazole. Itraconazole has proved efficacious for the treatment of subacute to chronic infections with the endemic mycoses and other opportunistic
Lamivudine. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection.: Drugs. 1997 Apr;53(4):657-80. Unique Identifier : AIDSLINE MED/97253222; Perry CM; Faulds D; Adis International Limited, Auckland, New Zealand.; Lamivudine is a dideoxynucleoside analogue which undergoes intracellular phosphorylation to the putative active metabolite, lamivudine triphosphate. Lamivudine triphosphate prevents HIV replication by competitively inhibiting viral reverse transcripta
mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.: EMBO J. 1997 Apr 15;16(8):2054-60. Unique Identifier : AIDSLINE MED/97299882; Hilfiker A; Hilfiker-Kleiner D; Pannuti A; Lucchesi JC; Department of Biology and Graduate Program in Genetics and Molecular; Biology, Emory University, Atlanta, GA 30322, USA.; Dosage compensation is a regulatory process that insures that males and females have equal amounts of X-chromosome gene products. In Drosophila, this is achieved by a 2-fold enhancement of X-linked gene transcription in males, relative to females. The enhancement of transcription is mediated by the activity of a group
Human ribosomal protein L7 binds RNA with an alpha-helical arginine-rich and lysine-rich domain.: Eur J Biochem. 1997 May 1;245(3):549-56. Unique Identifier : AIDSLINE MED/97325977; Hemmerich P; Bosbach S; von Mikecz A; Krawinkel U; Universitat Konstanz, Lehrstuhl fur Immunologie, Germany.; In this study we mapped the RNA-binding domain of human ribosomal protein L7 and characterized its conformation-dependent RNA-binding specificity. Binding competition assays demonstrated preferential binding of L7 to mRNAs and rRNA, but not to tRNA. The ribohomopolymer poly(G) is bound with high affinity whereas poly(
Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution.: Eur J Biochem. 1997 May 1;245(3):581-8. Unique Identifier : AIDSLINE MED/97325981; Willbold D; Hoffmann S; Rosch P; Lehrstuhl fur Biopolymere, Universitat Bayreuth, Germany.; Dieter.Willbold@uni-bayreuth.de; The human immunodeficiency virus type 1 Vpu protein enhances virus particle release from infected cells, decreases the tendency of syncytia formation and induces degradation of human CD4 receptor. It is known that the cytoplasmic part of Vpu is responsible for direct interaction to and degradation of CD4. The tertiary
Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects.: Eur J Immunol. 1997 May;27(5):1131-9. Unique Identifier : AIDSLINE MED/97317589; Bellinghausen I; Metz G; Enk AH; Christmann S; Knop J; Saloga J; Department of Dermatology, University of Mainz, Germany.; The current study was carried out to elucidate the immunoregulatory changes induced by venom immunotherapy (VIT) in bee or wasp allergic subjects. All subjects included in this study had a history of severe systemic allergic reactions to stings of the respective insect as well as positive skin tests with the respectiv
Effect of interleukin-10 on dendritic cell maturation and function.: Eur J Immunol. 1997 May;27(5):1229-35. Unique Identifier : AIDSLINE MED/97317602; De Smedt T; Van Mechelen M; De Becker G; Urbain J; Leo O; Moser M; Departement de Biologie Moleculaire, Universite Libre de Bruxelles,; Rhode-Saint-Genese, Belgium.; The main function of dendritic cells (DC) is to induce the differentiation of naive T lymphocytes into helper cells producing a large array of lymphokines, including interleukin IL)-2; interferon-gamma (IFN-gamma), IL-4, IL-5 and IL-10. The potent immunostimulatory properties of DC develop during a process of maturati
Survival after AIDS diagnosis in Tuscany (Italy), 1985-1992.: Eur J Epidemiol. 1997 Feb;13(2):125-32. Unique Identifier : AIDSLINE MED/97239331; Barchielli A; Acciai S; Lazzeri V; Buiatti E; Epidemiology Unit, Center for Study and Prevention of Cancer,; Florence, Italy.; The study evaluated the overall survival after AIDS diagnosis of 1,014 patients reported to the Italian AIDS Registry as resident in Tuscany, stratified by age, gender, year of diagnosis, HIV transmission category, initial AIDS-defining disease and CD4+ cells count. The study was a population-based survival analysis,
MHC-dependent cytolysis of autologous tumor cells by lymphocytes infiltrating urothelial carcinomas.: Int J Cancer. 1997 May 16;71(4):585-94. Unique Identifier : AIDSLINE MED/97322158; Housseau F; Zeliszewski D; Roy M; Paradis V; Richon S; Ricour A; Bougaran J; Prapotnich D; Vallancien G; Benoit G; Desportes L; Bedossa P; Hercend T; Bidart JM; Bellet D; Laboratory of Tumor Immunology, URA 1484 CNRS, University of Rene; Descartes, Paris, France.; Tumor-infiltrating lymphocytes (TIL) were grown from 23 urothelial carcinomas. Phenotyping analysis showed that the TIL cultures were mainly CD3+. Although CD4+ and CD8+ T-cell sub-sets were grown in culture, CD4+ T-cell sub-sets predominated over CD8+ T cells. Immunohistochemical studies performed on 5 tumor specimen
Are cancers of the salivary gland increasing? Experience from Connecticut, USA.: Int J Epidemiol. 1997 Apr;26(2):264-71. Unique Identifier : AIDSLINE MED/97312719; Zheng T; Holford TR; Chen Y; Ward B; Liu W; Flannery J; Boyle P; Yale School of Medicine, Yale Cancer Center, New Haven, CT 06520-8034,; USA.; BACKGROUND: Recent studies indicate that cancers of the salivary gland are increasing, and the factors responsible for the increase are unknown. Artefactual changes, such as shift in classifying cancers of the floor of the mouth to cancers of the salivary gland, could affect the time trend for salivary gland cancer. M
Survival of AIDS patients according to type of AIDS-defining event. The AIDS in Europe Study Group.: Int J Epidemiol. 1997 Apr;26(2):400-7. Unique Identifier : AIDSLINE MED/97312736; Mocroft AJ; Lundgren JD; d'Armino Monforte A; Ledergerber B; Barton SE; Vella S; Katlama C; Gerstoft J; Pedersen C; Phillips AN; Dept Primary Care and Population Sciences, Royal Free Hospital School; of Medicine, London, UK.; BACKGROUND: There are known to be wide differences in the prognosis of patients with a diagnosis of AIDS. In this study of 6578 patients with AIDS form 17 European centres, we develop a ranking of AIDS-defining illnesses, and determine how well this ranking holds after adjustment for potential confounding variables. M
HIV-related risk factors of blood donors in northern Thailand before and after knowing HIV test results.: Int J Epidemiol. 1997 Apr;26(2):408-13. Unique Identifier : AIDSLINE MED/97312737; Sawanpanyalert P; Uthaivoravit W; Yanai H; Limpakarnjanarat K; Mastro TD; Nelson KE; Department of Medical Services, Ministry of Public Health, Muang; Nonthaburi, Thailand.; BACKGROUND: The epidemic of Human Immunodeficiency Virus (HIV) infection led blood banks to initiate donation deferral criteria based on self-reported risk factors. However little information is available on the differences in reporting risk factors before and after HIV status is known. METHODS: Between April and July
HIV infection and sexual behaviour among women with infertility in Tanzania: a hospital-based study.: Int J Epidemiol. 1997 Apr;26(2):414-9. Unique Identifier : AIDSLINE MED/97312738; Favot I; Ngalula J; Mgalla Z; Klokke AH; Gumodoka B; Boerma JT; Bugando Medical Centre, Mwanza, Tanzania.; BACKGROUND: Infertility is common in Africa, but virtually no data exist on HIV prevalence among infertile women. Mainly anthropological studies in Africa have shown that infertile women have higher risks of marital instability and possibly also have more sexual partners than fertile women. METHOD: This study was cond
[Th1 cells, Th2 cells and atopic dermatitis]: Hautarzt. 1997 Apr;48(4):223-7. Unique Identifier : AIDSLINE MED/97295467; Bohm I; Bauer R; Universitats-Hautklinik, Rheinischen Friedrich-Wilhelms-Universitat; Bonn.; The immunological hallmark of atopic dermatitis (AD) is a Th1/Th2 dysbalance. The reaction to high molecular weight environmental allergens (e.g. pollen, house dust mites), production of IgE and activation of eosinophil granulocytes result from Th2 dominance. The Th2-cytokine interleukin-4 (IL-4) is necessary for IgE
[Kaposi sarcoma in cyclosporin A therapy of actinic reticuloid]: Hautarzt. 1997 Apr;48(4):262-5. Unique Identifier : AIDSLINE MED/97295475; Waldmann V; Kempf W; Burg G; Dummer R; Dermatologische Klinik, Universitatsspital Zurich.; A 76 year old patient with actinic reticuloid was treated with Cyclosporin A. 11 months after beginning the immunosuppressive therapy, he developed lymphoedema and livid nodular skin lesions of the right leg, which histologically showed Kaposi s sarcoma. After stopping the Cyclosporin A and intralesional therapy with
[T-helper cells: the key to the pathogenesis of psoriasis?]: Hautarzt. 1997 Apr;48(4):291. Unique Identifier : AIDSLINE MED/97295481
Fusion peptides derived from the HIV type 1 glycoprotein 41 associate within phospholipid membranes and inhibit cell-cell Fusion. Structure-function study.: J Biol Chem. 1997 May 23;272(21):13496-505. Unique Identifier : AIDSLINE MED/97298046; Kliger Y; Aharoni A; Rapaport D; Jones P; Blumenthal R; Shai Y; Department of Membrane Research and Biophysics, Weizmann Institute of; Science, Rehovot, 76100 Israel.; The fusion domain of human immunodeficiency virus (HIV-1) envelope glycoprotein (gp120-gp41) is a conserved hydrophobic region located at the N terminus of the transmembrane glycoprotein (gp41). A V2E mutant has been shown to dominantly interfere with wild-type envelope-mediated syncytium formation and virus infectivi
Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation.: J Biol Chem. 1997 May 23;272(21):13779-85. Unique Identifier : AIDSLINE MED/97298085; Liu LX; Margottin F; Le Gall S; Schwartz O; Selig L; Benarous R; Benichou S; Institut Cochin de Genetique Moleculaire, INSERM U332, Universite; Paris V, 24 Rue du Faubourg Saint-Jacques, 75014 Paris, France.; Nef is a 27-kDa myristoylated protein conserved in primate lentiviruses. In vivo, simian immunodeficiency virus Nef is required in macaques to produce a high viral load and full pathological effects. Nef has at least three major effects in vitro, induction of CD4 down-regulation, alteration of T cell activation pathwa
Perspectives series: host/pathogen interactions. Dynamics of HIV-1 replication in vivo.: J Clin Invest. 1997 Jun 1;99(11):2565-7. Unique Identifier : AIDSLINE MED/97313490; Ho DD; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York 10016, USA. dho@adarc.org
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.: J Clin Invest. 1997 Jun 1;99(11):2752-61. Unique Identifier : AIDSLINE MED/97313512; Gupta S; Pablo AM; Jiang Xc; Wang N; Tall AR; Schindler C; Department of Medicine, Columbia University, New York 10032, USA.; The early colocalization of T cells and the potent immunostimulatory cytokine IFN-gamma to atherosclerotic lesions suggest that the immune system contributes to atherogenesis. Since mice with a targeted disruption of the apoE gene (apoE 0 mice) develop profound atherosclerosis, we examined the role of IFN-gamma in thi
Support group membership and perceptions of control over health in HIV+ men.: J Clin Psychol. 1997 Apr;53(3):249-52. Unique Identifier : AIDSLINE MED/97229056; Fontaine KR; McKenna L; Cheskin LJ; Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.; krf@welchlink.welch.jhu.edu; We compared health-related control perceptions in 115 HIV+ gay/ bisexual British men who were or were not members of an AIDS support group. Participants completed the Multidimensional Health Locus of Control Scale (MHLC). Compared to those who were not members of a support group, HIV+ men who belonged to a support gro
A case of adult T-cell leukemia/lymphoma (ATLL) with angiocentric and angiodestructive features.: J Dermatol. 1997 Mar;24(3):165-9. Unique Identifier : AIDSLINE MED/97269557; Ohtake N; Setoyama M; Fukumaru S; Kanzaki T; Department of Dermatology, Kagoshima University Faculty of Medicine,; Japan.; This report describes a case of adult T-cell leukemia/lymphoma ATLL) with angiocentric and angiodestructive features. The patient was a 66-year-old Japanese woman who began developing widespread skin lesions ten months prior to admission. The diagnosis of ATLL was made on the basis of her having an antibody to human T
Decreased fat and nitrogen losses in patients with AIDS receiving medium-chain-triglyceride-enriched formula vs those receiving long-chain-triglyceride-containing formula.: J Am Diet Assoc. 1997 Jun;97(6):605-11. Unique Identifier : AIDSLINE MED/97326499; Craig GB; Darnell BE; Weinsier RL; Saag MS; Epps L; Mullins L; Lapidus WI; Ennis DM; Akrabawi SS; Cornwell PE; Sauberlich HE; Department of Nutrition Sciences, School of Health Related; Professions, University of Alabama at Birmingham 35294, USA.; OBJECTIVE: The purpose of this study was to compare two enteral formulas, differing only in fat source, for product acceptance, tolerance, and effect on fat malabsorption and nutritional status in subjects with acquired immune deficiency syndrome (AIDS). DESIGN: The double-blind, randomized 15-day trial was divided in
Spectrum of clinical and laboratory characteristics of HIV infection in northern India.: J Commun Dis. 1995 Sep;27(3):131-41. Unique Identifier : AIDSLINE MED/97306405; Giri TK; Pande I; Mishra NM; Kailash S; Uppal SS; Kumar A; Department of Medicine, All India Institute of Medical Sciences, New; Delhi.; To define the impact of HIV infection in India , the clinical and laboratory profile and the correlation of CD4 count to the likely opportunistic infection in a cohort of 134 HIV positive patients in Northern India was analysed. Majority of the patients, 72% and 67.8% (children and a
No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders.: J Invest Dermatol. 1997 Jun;108(6):920-2. Unique Identifier : AIDSLINE MED/97325810; Henghold WB 2nd; Purvis SF; Schaffer J; Giam CZ; Wood GS; Department of Dermatology, Case Western Reserve University, Cleveland,; Ohio, USA.; The recently discovered human virus known as Kaposi s sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 HHV-8) has been associated with body-cavity-based lymphomas in AIDS patients. It is most closely related to two other herpesviruses, the Epstein-Barr virus and herpesvirus saimiri, which are known to be a
Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions.: J Infect Dis. 1997 Jun;175(6):1324-32. Unique Identifier : AIDSLINE MED/97323974; Webster-Cyriaque J; Edwards RH; Quinlivan EB; Patton L; Wohl D; Raab-Traub N; Department of Microbiology and Immunology and Lineberger Cancer; Center, University of North Carolina at Chapel Hill, 27599-7295, USA.; The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi s sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymera
Diagnosis of perinatal human immunodeficiency virus infection by polymerase chain reaction and p24 antigen detection after immune complex dissociation in an urban community hospital.: J Infect Dis. 1997 Jun;175(6):1333-6. Unique Identifier : AIDSLINE MED/97323975; Nesheim S; Lee F; Kalish ML; Ou CY; Sawyer M; Clark S; Meadows L; Grimes V; Simonds RJ; Nahmias A; Department of Pediatrics, Emory University School of Medicine, and; Centers for Disease Control and Prevention, Atlanta, Georgia 30335,; USA.; Results of polymerase chain reaction (PCR) and p24 antigen detection after immune complex dissociation (p24-ICD) were compared with antibody results after 18 months of age for human immunodeficiency virus (HIV) diagnosis in 345 prospectively followed, perinatally exposed infants. Of 59 infected and 286 uninfected infa
Experimental perinatal transmission of human immunodeficiency virus type 1 by passage of infected T cells.: J Infect Dis. 1997 Jun;175(6):1337-43. Unique Identifier : AIDSLINE MED/97323976; Simpson RM; Hubbard BS; Zhao TM; Kindt TJ; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Diseases, National Institutes of Health Twinbrook Facility,; Rockville, Maryland 20852, USA.; Pediatric AIDS typically follows transmission of human immunodeficiency virus type 1 (HIV-1) from infected mothers to their offspring. The possibility that infected maternal-origin cells serve as a conveyance for mother-to-child HIV-1 transmission was investigated in a rabbit infection model. Administration of HIV-1-i
Additive or sequential nucleoside analogue therapy compared with continued zidovudine monotherapy in human immunodeficiency virus-infected patients with advanced disease does not prolong survival: an observational study.: J Infect Dis. 1997 Jun;175(6):1344-51. Unique Identifier : AIDSLINE MED/97323977; van Leeuwen R; Bonsel GJ; Reiss P; Danner SA; Lange JM; Academic Medical Center, University of Amsterdam, Department of; Medicine, Netherlands.; To study the effect of sequential or additive use of zalcitabine or didanosine on survival in 308 human immunodeficiency virus-infected patients with advanced disease treated with zidovudine, an observational study using time-dependent Cox proportional hazards models was done. Changing to sequential or additive therap
Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hosts.: J Infect Dis. 1997 Jun;175(6):1352-9. Unique Identifier : AIDSLINE MED/97323978; Michael NL; Brown AE; Voigt RF; Frankel SS; Mascola JR; Brothers KS; Louder M; Birx DL; Cassol SA; Division of Retrovirology, Walter Reed Army Institute of Research, and; Henry M. Jackson Foundation, Rockville, Maryland 20850, USA.; A patient is described who rapidly progressed from primary human immunodeficiency virus (HIV) type 1 infection to death without seroconversion but with consistently high plasma viremia. His asymptomatic sex partner had been HIV-1 seropositive for >8 years prior to transmission. Analysis of viral sequences from these s
Characterization of a polyclonal cytolytic T lymphocyte response to human immunodeficiency virus in persons without clinical progression.: J Infect Dis. 1997 Jun;175(6):1360-7. Unique Identifier : AIDSLINE MED/97323979; Lubaki NM; Ray SC; Dhruva B; Quinn TC; Siliciano RF; Bollinger RC; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; A total of 82 human immunodeficiency virus (HIV)-1-specific cytolytic T lymphocyte (CTL) clones were isolated and characterized from 5 HIV-infected subjects, utilizing multiple HLA class I alleles. B62-restricted, HIV-1 gag-specific CTL clones isolated from a single blood sample from 1 subject used four different Vbet
Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice.: J Infect Dis. 1997 Jun;175(6):1368-81. Unique Identifier : AIDSLINE MED/97323980; Limoges J; Persidsky Y; Bock P; Gendelman HE; Department of Pathology, and the Eppley Institute for Research in; Cancer and Allied Medicine, University of Nebraska Medical Center,; Omaha 68198-5215, USA.; Human immunodeficiency virus (HIV) dementia is a late complication of viral infection. Cognitive dysfunction revolves around the secretion of neurotoxins from immunologically competent virus-infected brain macrophages and microglia. Such macrophage neurotoxins are inflammatory fact
Iron overload alters innate and T helper cell responses to Candida albicans in mice.: J Infect Dis. 1997 Jun;175(6):1467-76. Unique Identifier : AIDSLINE MED/97323992; Mencacci A; Cenci E; Boelaert JR; Bucci P; Mosci P; Fe d'Ostiani C; Bistoni F; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; The effect of iron overload on susceptibility of mice to Candida albicans infection and on the type of T helper (Th) immunity elicited was investigated. Iron overload greatly increased susceptibility to disseminated infection with low-virulence C. albicans cells of exogenous origin. The candidacidal activity and the a
Cytomegalovirus monitoring by polymerase chain reaction of whole blood samples from patients undergoing autologous bone marrow or peripheral blood progenitor cell transplantation.: J Infect Dis. 1997 Jun;175(6):1490-3. Unique Identifier : AIDSLINE MED/97323995; Hebart H; Schroder A; Loffler J; Klingebiel T; Martin H; Wassmann B; Gerneth F; Rabenau H; Jahn G; Kanz L; Muller CA; Einsele H; Medizinische Universitatsklinik, Abteilung II, Kinderklinik, Institut; fur Medizinische Informationsverarbeitung, and Abteilung fur; Medizinische Virologie, Universitat Tubingen, Germany.; Sensitive screening for cytomegalovirus ( CMV ) by polymerase chain reaction (PCR) following autologous bone marrow or peripheral blood progenitor cell transplantation has not been evaluated. In a three-center study, 98 autogra
Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine. Sydney Primary HIV Infection Study Group.: J Infect Dis. 1997 Jun;175(6):1502-6. Unique Identifier : AIDSLINE MED/97323998; Imrie A; Beveridge A; Genn W; Vizzard J; Cooper DA; Centre for Immunology, St Vincent's Hospital, Grosvenor Clinic,; Woolhara, Australia.; Human immunodeficiency virus type 1 (HIV-1) resistant to the nonnucleoside reverse transcriptase inhibitor nevirapine and to the nucleoside analogue zidovudine was transmitted from a homosexual man to his sex partner. The virus source patient had comm
Decreased short-term production of tumor necrosis factor-alpha and interleukin-1beta in human immunodeficiency virus-seropositive subjects.: J Infect Dis. 1997 Jun;175(6):1507-10. Unique Identifier : AIDSLINE MED/97323999; Ullum H; Victor J; Katzenstein TL; Gerstoft J; Gotzsche PC; Bendtzen K; Skinhoj P; Pedersen BK; Department of Infectious Diseases and Institute for Inflammation; Research, Rhima Centre, Rigshospitalet, Copenhagen, Denmark.; Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta IL-1beta) were measured by ELISA in 4.5-h, lipopolysaccharide-stimulated whole blood cultures of 347 human immunodeficiency virus type 1-infected patients and 107 healthy seronegative controls. The production of TNF-alpha was decreased in both AIDS and non-
Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair.: J Infect Dis. 1997 Jun;175(6):1510-5. Unique Identifier : AIDSLINE MED/97324000; Wang B; Ge YC; Jozwiak R; Bolton W; Palasanthiran P; Ziegler J; Chang J; Xiang SH; Cunningham AL; Saksena NK; Centers for Virus Research, Westmead Institutes for Health Research,; Westmead Hospital, NSW, Sydney, Australia.; Molecular analyses were done for the V3 region quasispecies of human immunodeficiency virus type 1 (HIV-1) strains from plasma and peripheral blood mononuclear cells of the first HIV-1-infected long-term-nonprogressing mother-child pair whose members have survived for >13 years with stable CD4 T cell counts. There was
Infection of human monocytes with Mycobacterium tuberculosis enhances human immunodeficiency virus type 1 replication and transmission to T cells.: J Infect Dis. 1997 Jun;175(6):1531-5. Unique Identifier : AIDSLINE MED/97324005; Mancino G; Placido R; Bach S; Mariani F; Montesano C; Ercoli L; Zembala M; Colizzi V; Department of Biology, University of Rome Tor Vergata, Institute of; Experimental Medicine, National Research Council, Italy.; Mycobacterium tuberculosis and human immunodeficiency virus type 1 (HIV-1) are virulent intracellular pathogens that invade and multiply within macrophages. The effect of M. tuberculosis on HIV-1 infection and replication was analyzed in vitro using human monocyte-derived macrophages (MDM) isolated from peripheral blo
Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor NF)-kappaB.: J Exp Med. 1997 Jun 2;185(11):1897-907. Unique Identifier : AIDSLINE MED/97311088; Boothby MR; Mora AL; Scherer DC; Brockman JA; Ballard DW; Department of Microbiology and Immunology, Vanderbilt University; Medical Center, Nashville, Tennessee 37232, USA.; Members of the nuclear factor (NF)-kappaB/Rel family transcription factors are induced during thymic selection and in mature T lymphocytes after ligation of the T cell antigen receptor (TCR). Despite these findings, disruption of individual NF-kappaB/Rel genes has revealed no intrinsic defect in the development of mat
T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.: J Exp Med. 1997 Jun 2;185(11):1969-75. Unique Identifier : AIDSLINE MED/97311095; Sciammas R; Kodukula P; Tang Q; Hendricks RL; Bluestone JA; Ben May Institute for Cancer Research, Department of Pathology and; Committee on Immunology, University of Chicago, Chicago, Illinois; 60637, USA.; Increased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influenza and sendai virus infections, as well as in patients infected with human immunodeficiency virus and herpes simplex virus type 1 (HSV-1). However, a direct role for TCR-gamma/delta cells in protective immunity f
9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation.: J Exp Med. 1997 Jun 2;185(11):1997-2013. Unique Identifier : AIDSLINE MED/97311098; Krishna M; Varki A; Glycobiology Program, UCSD Cancer Center, the Department of Medicine,; University of California, San Diego, La Jolla, California 92093, USA.; Terminal sialic acids on cell surface glycoconjugates can carry 9-O-acetyl esters. For technical reasons, it has previously been difficult to determine their precise distribution on different cell types. Using a recombinant soluble form of the Influenza C virus hemagglutinin-esterase as a probe for 9-O-acetylated sial
STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.: J Exp Med. 1997 Jun 2;185(11):2015-23. Unique Identifier : AIDSLINE MED/97311099; Liao F; Alkhatib G; Peden KW; Sharma G; Berger EA; Farber JM; Laboratory of Clinical Investigation, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland, USA.; The chemokine receptors CXCR4, CCR2B, CCR3, and CCR5 have recently been shown to serve along with CD4 as coreceptors for HIV-1. The tropisms of HIV-1 strains for subgroups of CD4(+) cells can be explained, at least partly, by the selective use of G protein-coupled receptors (GPCRs). We have identified a novel human ge
Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology.: J Med Virol. 1997 May;52(1):1-7. Unique Identifier : AIDSLINE MED/97278116; Vandamme AM; Van Laethem K; Liu HF; Van Brussel M; Delaporte E; de Castro Costa CM; Fleischer C; Taylor G; Bertazzoni U; Desmyter J; Goubau P; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Belgium.; In countries with a low prevalence of human T-lymphotropic virus HTLV) infection, indeterminate HTLV serologies are a major problem in blood bank screening because of the uncertainties about infection in these cases. The recent discovery of two new types of simian T-lymphotropic viruses (STLV), which give an HTLV-inde
Comparison of HCV RNA assays for the detection and quantification of hepatitis C virus RNA levels in serum of patients with chronic hepatitis C treated with interferon.: J Med Virol. 1997 May;52(1):105-12. Unique Identifier : AIDSLINE MED/97278132; Trabaud MA; Bailly F; Si-Ahmed SN; Chevallier P; Sepetjan M; Colucci G; Trepo C; Unite de recherche sur les Virus des hepatites, (INSERM U271), Lyon,; France.; Detection and quantification of hepatitis C virus (HCV) RNA levels by using the standardized qualitative Amplicor HCV and quantitative Amplicor HCV Monitor assays (Roche Molecular Systems) were evaluated in 48 patients with chronic hepatitis C treated with interferon. Results were compared with an in-house reverse tra
Evaluation of the presence of 2-LTR HIV-1 unintegrated DNA as a simple molecular predictor of disease progression.: J Med Virol. 1997 May;52(1):20-5. Unique Identifier : AIDSLINE MED/97278119; Zazzi M; Romano L; Catucci M; Venturi G; De Milito A; Almi P; Gonnelli A; Rubino M; Occhini U; Valensin PE; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; In a preliminary cross-sectional analysis of 109 human immunodeficiency virus type 1 (HIV-1)-infected subjects the presence of 2-long terminal repeat (LTR) unintegrated circular HIV-1 DNA in peripheral blood mononuclear cells (PBMC) was found to be associated with both symptomatic infection (P = 0.0037) and low CD4 co
Phenotypic variations and switches in HIV isolated from the blood and the gastrointestinal tissues of patients with HIV-1 infection. HIV/GI Research Study Group.: J Med Virol. 1997 May;52(1):31-4. Unique Identifier : AIDSLINE MED/97278121; al-Mulla W; Church D; Gill MJ; Faculty of Medicine, Kuwait University, Kuwait.; The objective of this study was to determine the initial and subsequent phenotypes of HIV-1 isolated from the blood, duodenal, and colonic biopsies of 51 HIV-1 positive patients followed prospectively over 2 years. Blood and tissues were cocultured with stimulated peripheral blood monocytes, and HIV was analyzed for p
Common origin of human T-lymphotropic virus type-I from Iran, Kuwait, Israel, and La Reunion Island.: J Med Virol. 1997 May;52(1):77-82. Unique Identifier : AIDSLINE MED/97278127; Voevodin A; Gessain A; Department of Microbiology, Faculty of Medicine, Kuwait University,; Kuwait.; We found previously that Kuwaiti HTLV-I isolates had two nucleotide substitutions in the most frequently sequenced regions of HTLV-I genome, namely: T-->C 4783 in the pol and T-->C 6569 the env genes. These substitutions were observed rarely in other HTLV-I isolates and seemed to be good markers of the HTLV-I lineage,
Interleukin (IL)-1 beta and IL-1 beta mRNA expression in normal and diseased skeletal muscle assessed by immunocytochemistry, immunoblotting and reverse transcriptase-nested polymerase chain reaction.: J Neuropathol Exp Neurol. 1997 Jun;56(6):651-63. Unique Identifier : AIDSLINE MED/97328098; Belec L; Authier FJ; Chazaud B; Piedouillet C; Barlovatz-Meimon G; Gherardi RK; Groupe d'Etude et de Recherche sur le Nerf Et le Muscle, Faculte de; Medecine de Creteil-Paris XII, France.; To confirm the production of IL-1 beta and to optimize detection and semiquantitation of IL-1 beta mRNA by polymerase chain reaction (PCR) techniques in skeletal muscle tissue, immunocytochemistry, immunoblotting and several procedures of RNA extraction and reverse transcription (RT)-PCR amplification were used on mus
The neuropathology of HIV-infected African children in Abidjan, Cote d'Ivoire.: J Neuropathol Exp Neurol. 1997 Jun;56(6):686-92. Unique Identifier : AIDSLINE MED/97328101; Bell JE; Lowrie S; Koffi K; Honde M; Andoh J; De Cock KM; Lucas SB; Department of Neuropathology, University of Edinburgh, Western General; Hospital.; In an autopsy study of HIV-infected children in Abidjan, Cote d Ivoire , the neuropathology of 76 HIV-1- and 2 HIV-2-positive children was compared with that of 77 frequency-matched HIV-negative children, in whom the systemic pathology was also known. Seventy of the 78 HIV-sero
Zidovudine adherence in persons with AIDS. The relation of patient beliefs about medication to self-termination of therapy.: J Gen Intern Med. 1997 Apr;12(4):216-23. Unique Identifier : AIDSLINE MED/97272519; Smith MY; Rapkin BD; Morrison A; Kammerman S; Psychiatry Service, Memorial Sloan-Kettering Cancer Center, New York,; NY 10021, USA.; OBJECTIVE: To examine the relation of patient beliefs about medication usage and adherence to zidovudine (ZDV) therapy in persons with AIDS. DESIGN: Face-to-face interviews were used to determine attitudes of persons with AIDS toward ZDV and other prescribed medications, history of ZDV usage, and sociodemographics. SE
HIV-infected competitive athletes. What are the risks? What precautions should be taken?: J Gen Intern Med. 1997 Apr;12(4):243-6. Unique Identifier : AIDSLINE MED/97272523; Feller A; Flanigan TP; Graduate School of Biomedical Sciences, Bryn Mawr College, PA, USA.
Childhood sexual abuse among homosexual men. Prevalence and association with unsafe sex.: J Gen Intern Med. 1997 Apr;12(4):250-3. Unique Identifier : AIDSLINE MED/97272525; Lenderking WR; Wold C; Mayer KH; Goldstein R; Losina E; Seage GR 3rd; Department of Biostatistics, Harvard School of Public Health, Boston,; MA, USA.; Of 327 homosexual and bisexual men participating in an ongoing cohort study pertaining to risk factors for HIV infection who completed a survey regarding history of sexual abuse, 116 (35.5%) reported being sexually abused as children. Those abused were more likely to have more lifetime male partners, to report more ch
The utility of direct acid-fast stain of cerebrospinal fluid for the rapid diagnosis of tuberculous meningitis in patients with and without AIDS [letter]: J Gen Intern Med. 1997 Apr;12(4):259. Unique Identifier : AIDSLINE MED/97272530; Dural AT; Johnson PC; Wagner A
Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.: J Med Chem. 1997 May 23;40(11):1707-9. Unique Identifier : AIDSLINE MED/97315875; De Lucca GV; Liang J; Aldrich PE; Calabrese J; Cordova B; Klabe RM; Rayner MM; Chang CH; DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500,; USA.; Re-examination of the design of the cyclic urea class of HIV protease (HIVPR) inhibitors suggests a general approach to designing novel nonpeptide cyclic HIVPR inhibitors. This process involves the inversion of the stereochemical centers of the core transition-state isostere of the linear HIVPR inhibitors and cyclizat
HIV infection with Hodgkin's disease: the virus makes a difference [news]: J Natl Cancer Inst. 1997 Jun 4;89(11):754-5. Unique Identifier : AIDSLINE MED/97325956; McNeil C
[Analysis of T cell subsets with monoclonal antibodies]: Nippon Rinsho. 1997 Mar;55 Suppl 1:159-65. Unique Identifier : AIDSLINE MED/97251974; Homma T; Morimoto C; Department of Clinical Immunology, University of Tokyo Institute of; Medical Science.
Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines.: Leukemia. 1997 Jun;11(6):866-70. Unique Identifier : AIDSLINE MED/97320591; Cereseto A; Berneman Z; Koralnik I; Vaughn J; Franchini G; Klotman ME; Laboratory of Tumor Cell Biology, National Cancer Institute, National; Institutes of Health, Bethesda, MD, USA.; Human T cell leukemia/lymphotropic virus (HTLV) is a complex 9 kb human retrovirus with at least eight alternatively spliced mRNAs expressed from the 3 or pX region of the genome. These mRNAs allow for the expression of novel proteins from the previously recognized pX open reading frames I and II in addition to Tax,
Angioimmunoblastic lymphadenopathy with disseminated human herpesvirus 6 infection in a patient with acute myeloblastic leukemia.: Leukemia. 1997 Jun;11(6):882-5. Unique Identifier : AIDSLINE MED/97320593; Daibata M; Ido E; Murakami K; Kuzume T; Kubonishi I; Taguchi H; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.; A 47-year-old man with acute myeloblastic leukemia (AML) developed angioimmunoblastic lymphadenopathy with dysproteinemia AILD) 4 months after induction chemotherapy for AML. During a leukopenic period, the patient suffered from pericarditis with massive pericardial effusion in which human herpesvirus 6 (HHV-6) DNA wa
Histological improvement in patients with chronic hepatitis B virus infection treated with lamivudine.: Liver. 1997 Apr;17(2):103-6. Unique Identifier : AIDSLINE MED/97284205; Honkoop P; de Man RA; Zondervan PE; Schalm SW; Department of Internal Medicine II, (Section Hepatology), Erasmus; University Hospital, Rotterdam, The Netherlands.; Lamivudine is an oral nucleoside analogue with strong antiviral activity against hepatitis B virus (HBV). In previous clinical studies, a course of lamivudine for 4-12 weeks induced a profound decrease in HBV viraemia with excellent tolerance, but dat
[Primary lung Kaposi sarcoma associated to AIDS in a heterosexual drug addict man]: Medicina (B Aires). 1996;56(4):397-402. Unique Identifier : AIDSLINE MED/97284270; Troncoso AR; Carranza CM; Romani AH; Patini SE; Berasaluce G; Canataro PA; Masini R; Macias JR; Hospital de Enfermedades Infecciosas Francisco J. Muniz, Buenos Aires,; argentina.; A case of lung Kaposi sarcoma (KS) in the absence of cutaneomucosal lesions was observed in a 30-year-old heterosexual male with AIDS and a history of intravenous drug addiction. Both chest X-ray and CT scanning disclosed a diffuse nodular pattern in lungs, whereas endoscopy failed to demonstrate endobronchial damage.
Advantage of dimeric peptide antigens in serodiagnosis of HIV-1 infection.: Microbiol Immunol. 1997;41(3):215-20. Unique Identifier : AIDSLINE MED/97276480; Gokulan K; Tripathi SP; Rao DN; Department of Biochemistry, All India Institute of Medical Sciences,; New Delhi, India.; The reactivity of antibodies with dimeric and monomeric peptide antigens was compared by ELISA. A panel of highly purified synthetic peptides of HIV-1 representing defined regions, 598-609 and 524-533 (fusion domain) of gp41 and 306-320 of gp120, were used as antigens in the ELISA. These peptides were selected and syn
Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice.: Microbiol Immunol. 1997;41(3):221-7. Unique Identifier : AIDSLINE MED/97276481; Hiromatsu K; Usami J; Aoki Y; Makino M; Yoshikai Y; Laboratory of Host Defense, Nagoya University School of Medicine,; Aichi, Japan.; We reported previously that CD4+ T cells and B cells in mice with retrovirus-induced murine acquired immunodeficiency syndrome MAIDS) caused by LP-BM5 murine leukemia virus (MuLV) mixtures increased the expression of Fas antigen (Fas) during progression of the disease. However, the contribution of the Fas/Fas ligand F
Infection of an HIV-1/SIVmac chimeric virus having HIV-1 env to macaque monkeys via the vaginal cavity.: Microbiol Immunol. 1997;41(3):277-80. Unique Identifier : AIDSLINE MED/97276488; Ido E; Okada M; Enose Y; Kuwata T; Igarashi T; Sata T; Terao K; Chen J; Hayami M; Laboratory of Pathogenic Virus, University, Japan.; We previously reported that an HIV-1/SIVmac chimeric virus designated as NM-3rN) having HIV-1 env efficiently infected macaque monkeys by intravenous inoculation. In this study, this chimeric virus was atraumatically inoculated into the vaginal cavity of two rhesus and one cynomolgus monkeys. Although antibody respons
Human immunodeficiency virus type-1 envelope glycoprotein gp120 induces expression of fusion regulatory protein (FRP)-1/CD98 on CD4+ T cells: a possible regulatory mechanism of HIV-induced syncytium formation.: Med Microbiol Immunol (Berl). 1997 Mar;185(4):237-43. Unique Identifier : AIDSLINE MED/97284220; Suga S; Tsurudome M; Ito M; Ohgimoto S; Tabata N; Nishio M; Kawano M; Komada H; Ito M; Sakurai M; Ito Y; Department of Microbiology, Mie University School of Medicine, Japan.; Syncytium formation is one of major cytopathic effects of human immunodeficiency virus (HIV) infection, and requires the interaction of CD4 molecules on uninfected cells with HIV envelope glycoprotein gp120 expressed on HIV-infected cells. Recent evidence suggests chemokine receptors function as fusion cofactors. We h
Feline immunodeficiency virus causes increased glutamate levels and neuronal loss in brain.: Neuroscience. 1997 Apr;77(4):1175-85. Unique Identifier : AIDSLINE MED/97277103; Power C; Moench T; Peeling J; Kong PA; Langelier T; Department of Internal Medicine and Medical Microbiology, University; of Manitoba, Winnipeg, Canada.; Feline immunodeficiency virus, like human immunodeficiency virus type 1, is a retrolentivirus causing neurological disease and immune suppression. Primary neurological complications, including human immunodeficiency virus encephalopathy and peripheral neuropathy , and
Changes in total, CD4+, and CD8+ lymphocytes during pregnancy and 1 year postpartum in human immunodeficiency virus-infected women. The Women and Infants Transmission Study.: Obstet Gynecol. 1997 Jun;89(6):967-74. Unique Identifier : AIDSLINE MED/97314134; Tuomala RE; Kalish LA; Zorilla C; Fox H; Shearer W; Landay A; Vermund SH; Landesman S; Burns D; Department of Obstetrics and Gynecology, Brigham and Women's Hospital,; Boston, Massachusetts, USA.; OBJECTIVE: To assess changes in lymphocyte subsets during pregnancy and 1 year postpartum in human immunodeficiency virus HIV)-infected women. METHODS: Changes in CD4+ and CD8+ cell counts, CD4 and CD8 percent, CD4/CD8 ratio, and total lymphocyte count and percent were assessed in each of 226 HIV-infected women follow
Down-regulation of murine susceptibility to cerebral malaria by inoculation with third-stage larvae of the filarial nematode Brugia pahangi.: Parasitology. 1997 Apr;114 ( Pt 4):333-8. Unique Identifier : AIDSLINE MED/97260944; Yan Y; Inuo G; Akao N; Tsukidate S; Fujita K; Department of Medical Zoology, School of Medicine, Tokyo Medical and; Dental University, Tokyo, Japan.; In areas where malaria is endemic, helminthic infections, caused by intestinal or filarial parasites, commonly coexist with malaria in the same individual. This study investigates the course of Plasmodium berghei malaria infection in CBA/J mice inoculated with irradiated attenuated 3rd-stage larvae (L3) of Brugia paha
[A new gamma-2 herpesvirus, defined as HHV8 or Kaposi's sarcoma herpes virus (KSHV), could be involved in the pathogenesis of Kaposi's sarcoma]: Pathologica. 1996 Dec;88(6):525-6. Unique Identifier : AIDSLINE MED/97269681; Ruco LP
High resolution fast quantitative docking using Fourier domain correlation techniques.: Proteins. 1997 Apr;27(4):493-506. Unique Identifier : AIDSLINE MED/97285913; Blom NS; Sygusch J; Departement de Biochimie, Universite de Montreal, Quebec, Canada.; A docking method based on finite grid forcefield sampling is proposed for fast evaluation of interaction energies between macromolecules and ligands. Forcefield used to calculate interaction energies utilizes a potential energy function composed of a 1/r-dependent electrostatic term and a (6-12) Lennard-Jones term f
Efficacy of paroxetine for the treatment of depression in the context of HIV infection.: Pharmacopsychiatry. 1997 Mar;30(2):70-1. Unique Identifier : AIDSLINE MED/97278435; Grassi B; Gambini O; Garghentini G; Lazzarin A; Scarone S; Department of Neuropsychiatric Sciences, University of Milan Medical; School, Italy.; Recent studies in the literature point out that HIV-infected subjects are affected by depression with a relatively high frequency. The aim of this study was to assess the efficacy and tolerability of paroxetine for the treatment of depression in the context of HIV infection. 15 HIV-infected subjects (10 patients with
Prevalence and predictors of depressive, anxiety and substance use disorders in HIV-infected and uninfected men: a longitudinal evaluation.: Psychol Med. 1997 Mar;27(2):395-409. Unique Identifier : AIDSLINE MED/97245073; Dew MA; Becker JT; Sanchez J; Caldararo R; Lopez OL; Wess J; Dorst SK; Banks G; Department of Psychiatry, University of Pittsburgh School of Medicine,; PA 15213, USA.; BACKGROUND: There is little agreement on whether the prevalence of psychiatric disorder is elevated in HIV-seropositive (HIV+) populations compared with uninfected persons. However, evaluation of this issue has been limited difficulties of sampling, study design and failure to control for other risk factors for disord
Prevalence and trends in homosexual behaviour in Norway.: Scand J Soc Med. 1997 Mar;25(1):33-8. Unique Identifier : AIDSLINE MED/97260825; Veierod MB; Eskild A; Stigum H; Thorvaldsen J; Magnus P; Department of Epidemiology, National Institute of Public Health,; Ullev~al University Hospital, Oslo, Norway.; The three main objectives of this study were to estimate the proportion of the Norwegian population with experience of homosexual behaviour, to study the degree of change in sexual practices among homosexual men during a 5-year period and to study the degree of change in sexual practices reported by HIV positive homos
New clues to asthma therapies [news]: Science. 1997 Jun 13;276(5319):1643-6. Unique Identifier : AIDSLINE MED/97343854; Vogel G
Causing cancer by remote control? [news; comment]: Science. 1997 Jun 20;276(5320):1788-9. Unique Identifier : AIDSLINE MED/97345601; Gura T
Does a common virus give HIV a helping hand? [news; comment]: Science. 1997 Jun 20;276(5320):1794. Unique Identifier : AIDSLINE MED/97345602; Balter M
Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients [see comments]: Science. 1997 Jun 20;276(5320):1851-4. Unique Identifier : AIDSLINE MED/97334439; Rettig MB; Ma HJ; Vescio RA; Pold M; Schiller G; Belson D; Savage A; Nishikubo C; Wu C; Fraser J; Said JW; Berenson JR; Division of Hematology and Oncology, Veterans Affairs West Los Angeles; Medical Center, Los Angeles, CA 90073, USA.; RETTIG.MATTHEW@WEST-LA.VA.GOV; Kaposi s sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells fr
Macrophages as a source of HIV during opportunistic infections.: Science. 1997 Jun 20;276(5320):1857-61. Unique Identifier : AIDSLINE MED/97334441; Orenstein JM; Fox C; Wahl SM; Department of Pathology, George Washington University, Washington, DC; 20037, USA. jmo@gwis2.circ.gwu.edu; The source of increasing viremia that characterizes the latter stages of human immunodeficiency virus (HIV) disease has remained a paradox because it occurs at a time when lymphoid tissue is quantitatively and qualitatively impaired, and the patients CD4 T lymphocytes are steadily declining. Here, macrophages, both i
Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry [see comments]: Science. 1997 Jun 20;276(5320):1874-8. Unique Identifier : AIDSLINE MED/97334446; Pleskoff O; Treboute C; Brelot A; Heveker N; Seman M; Alizon M; Inserm U.332, Institut Cochin de Genetique Moleculaire, 22 rue; Mechain, 75014 Paris, France.; The human cytomegalovirus encodes a beta-chemokine receptor US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of C
The hierarchical diffusion of AIDS and violent crime among U.S. metropolitan regions: inner-city decay, stochastic resonance and reversal of the mortality transition.: Soc Sci Med. 1997 Apr;44(7):935-47. Unique Identifier : AIDSLINE MED/97245157; Wallace R; Huang YS; Gould P; Wallace D; PISCS Inc., New York, NY 10027, USA.; Census data on migration within and between the 25 largest U.S. metropolitan areas-containing more than 113 million people-permit construction of a probability-of-contact matrix corresponding to a particular Markov process dominated by the nation s largest cities, a hierarchical structure. Regression models based on v
[An unjustified fear]: Soins Psychiatr. 1996 Feb;(180):47-8. Unique Identifier : AIDSLINE MED/96334687; Dupuy C
Give Virodene and the Minister a break! [editorial]: S Afr Med J. 1997 Mar;87(3):253. Unique Identifier : AIDSLINE MED/97283199; Ncayiyana DJ
Rebel with a cause.: S Afr Med J. 1997 Mar;87(3):263-4. Unique Identifier : AIDSLINE MED/97283200; van der Linde I
Should South Africa be preparing for HIV-1 vaccine efficacy trials? [editorial]: S Afr Med J. 1997 Mar;87(3):285-90. Unique Identifier : AIDSLINE MED/97283204; Morris L; van der Ryst E; Gray C; Williamson C
Fine-needle aspiration of lymph nodes [letter; comment]: S Afr Med J. 1997 Mar;87(3):342, 344. Unique Identifier : AIDSLINE MED/97283219; Parrish AG
The enhancement of wound healing with human skin allograft.: Surg Clin North Am. 1997 Jun;77(3):731-45. Unique Identifier : AIDSLINE MED/97338329; Spence RJ; Wong L; Johns Hopkins Medical School, Baltimore, Maryland, USA.; Although clean incisional wounds can be closed easily, contaminated wounds, wounds with tissue loss that cannot be closed primarily, and chronic wounds are generally not closed and suffer the effects of being open. It follows that wound healing would be enhanced if these wounds could be closed. This article describes
Introduction: recent advances in the pathogenesis of human immunodeficiency virus infection.: Springer Semin Immunopathol. 1997;18(3):253-6. Unique Identifier : AIDSLINE MED/97245188; Pantaleo G; Fauci AS; Laboratory of AIDS Immunopathogenesis, Department of Medicine, Centre; Hospitalier Universitaire Vadois (CHUV), Lausanne, Switzerland.
Virologic and immunologic events in primary HIV infection.: Springer Semin Immunopathol. 1997;18(3):257-66. Unique Identifier : AIDSLINE MED/97245189; Pantaleo G; Graziosi C; Fauci AS; Laboratory of AIDS Immunopathogenesis, Department of Internal; Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne,; Switzerland.
The role of viral dynamics in the pathogenesis of HIV disease and implications for antiviral therapy.: Springer Semin Immunopathol. 1997;18(3):267-83. Unique Identifier : AIDSLINE MED/97245190; Havlir DV; Richman DD; Department of Medicine, University of California, San Diego, USA.
Immune dysregulation and CD4+ T cell loss in HIV-1 infection.: Springer Semin Immunopathol. 1997;18(3):285-303. Unique Identifier : AIDSLINE MED/97245191; Meyaard L; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam, The; Netherlands.
Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies.: Springer Semin Immunopathol. 1997;18(3):305-22. Unique Identifier : AIDSLINE MED/97245192; Cohen OJ; Pantaleo G; Lam GK; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1876, USA.; Lymphoid tissue is a major reservoir of human immunodeficiency virus (HIV) infection in vivo. In addition, the lymphoid microenvironment provides a replicative advantage to the virus in that it provides a milieu of activated target cells that allows for efficient virus spread. The process of mobilization and activatio
Mechanisms of resistance to HIV infection.: Springer Semin Immunopathol. 1997;18(3):323-40. Unique Identifier : AIDSLINE MED/97245193; Paxton WA; Koup RA; Aaron Diamond AIDS Research Center, New York, NY 10016, USA.
HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication.: Springer Semin Immunopathol. 1997;18(3):341-54. Unique Identifier : AIDSLINE MED/97245194; Jassoy C; Walker BD; Institute for Virology and Immunobiology, Julius-Maximilians; University, Wurzburg, Germany.
Noncytolytic CD8 T cell-mediated suppression of HIV replication.: Springer Semin Immunopathol. 1997;18(3):355-69. Unique Identifier : AIDSLINE MED/97245195; Greenberg ML; Lacey SF; Chen CH; Bolognesi DP; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham, NC; 27710, USA.
Role of complement and Fc receptors in the pathogenesis of HIV-1 infection.: Springer Semin Immunopathol. 1997;18(3):371-90. Unique Identifier : AIDSLINE MED/97245196; Montefiori DC; Department of Surgery, Duke University Medical Center, Durham, NC; 27710, USA.
Simian immunodeficiency virus as a model of HIV pathogenesis.: Springer Semin Immunopathol. 1997;18(3):391-405. Unique Identifier : AIDSLINE MED/97245197; Norley S; Kurth R; Paul-Ehrlich-Institute, Langen, Germany.
Radioimmunoassay of zidovudine: extended use and potential application.: Ther Drug Monit. 1997 Apr;19(2):195-200. Unique Identifier : AIDSLINE MED/97262267; DeRemer M; D'Ambrosio R; Bartos L; Cousins S; Morse GD; Department of Pharmacy Practice, State University of New York at; Buffalo 14260, USA.; When first approved, the dosing regimens for zidovudine were 1,200-1,500 mg/day; however, because toxicity developed, the daily dose had to be reduced to 500-600 mg/day. At these lower doses, plasma concentrations for a considerable segment of the dosing interval are often below the assay sensitivity for the high-perf
Prevalence of hepatitis G virus RNA in French blood donors and recipients [see comments]: Transfusion. 1997 Jun;37(6):645-50. Unique Identifier : AIDSLINE MED/97335161; Loiseau P; Mariotti M; Corbi C; Ravera N; Girot R; Thauvin M; Portelette E; Mariette X; Roudot-Thoraval F; Benbunan M; Lefrere JJ; Etablissement de Transfusion Sanguine de l'Assistance; Publique-Hopitaux de Paris (AP-HP), Site Saint-Louis, France.; BACKGROUND: Recently, cases of chronic hepatitis were linked to the presence of genomic sequences of a newly described RNA virus termed hepatitis G virus (HGV) and belonging to the Flaviviridae family. STUDY DESIGN AND METHODS: The presence of HGV RNA was searched for by polymerase chain reaction in a population of bl
Interpretation of false-positive human immunodeficiency virus type 1 western blot assays in blood donors [letter]: Transfusion. 1997 Jun;37(6):670. Unique Identifier : AIDSLINE MED/97335166; Cable RG; Badon SJ; Trouem-Trend JJ; Popovsky MA
Database of HIV proteinase structures.: Trends Biochem Sci. 1997 May;22(5):183. Unique Identifier : AIDSLINE MED/97318602; Vondrasek J; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and; Development Center, Frederick, MD 21702, USA.
Evaluation of a new HTLV-I/II polymerase chain reaction.: Vox Sang. 1997;72(3):144-7. Unique Identifier : AIDSLINE MED/97290845; Vrielink H; Zaaijer HL; Cuypers HT; van der Poel CL; Woerdeman M; Lelie PN; Winkel C; Reesink HW; Red Cross Blood Bank Amsterdam, The Netherlands.; AIM: Evaluation of a qualitative HTLV-I/II DNA polymerase chain reaction (PCR) test for the detection of HTLV-I/II DNA (Roche Diagnostic Systems, Branchburg, N.J., USA) in various panels. METHODS: The panels consisted of fresh EDTA blood samples from blood donors who were anti-HTLV-I/II ELISA repeatably reactive: 53 w
[Cytotoxic T-lymphocytes and the recognition of tumor antigens--an approach to "preventive tumor vaccination?"]: Zentralbl Chir. 1997;122(3):141-8. Unique Identifier : AIDSLINE MED/97274958; Peiper M; Goedegebuure PS; Eberlein TJ; Zornig C; Biological Cancer Therapy Laboratory, Department of Surgery, Brigham &; Women's Hospital, Harvard Medical School, USA.; In spite of modifications of the intra- and postoperative therapeutic strategy as well as new adjuvant protocols, most malignant diseases have a poor prognosis. This demonstrates the need for new approaches in tumor therapy. One alternative is adoptive immunotherapy (AIT). AIT is based on the observation that cytotoxi
[Acute and chronic diarrhea in AIDS: study of 435 (HIV+) patients, in Buenos Aires]: Acta Gastroenterol Latinoam. 1996;26(1):15-22. Unique Identifier : AIDSLINE MED/97283547; Merlin M; Gandara S; Iannicillo H; Dutack A; Raffo L; Di Bartolomeo S; Di Bella A; Pelluffo G; Varsky C; Hospital Nacional Prof. A. Posadas Prov. Buenos Aires, Argentina.; OBJECTIVE: Assessment of the rate of Diarrhoea in an infected HIV population of our medium. Assessment of its etiology, risk factors and response to treatment in both presentation of disease Acute and chronic). DESIGN: This is a retrospective analysis of HIV and/or AIDS patients and diarrhea. The analytic points were:
[Diarrhea and AIDS: more complex diagnostic techniques; better therapeutic results]: Acta Gastroenterol Latinoam. 1996;26(2):91-100. Unique Identifier : AIDSLINE MED/97283558; Olmos M; Molina C; Piskorz E; Tawil J; Magnanini F; Casiro A; Cahn P; Concetti H; Janeiro M; Guelfand L; Kaufman S; Division de Gastroenterologia, Hospital Municipal J. A. Fernandez,; Buenos Aires, Argentina.; During 17 months, 73 HIV-positive patients with diarrhea lasting at least for 14 days, were studied prospectively. The patients had stool specimen examinations negative for enteric pathogens, or positive for one of them, but with no response to specific treatment. All patients were subcomitted to digestive endoscopy a
Treatment of AIDS and HIV-related conditions--1997.: J Am Board Fam Pract. 1997 Mar-Apr;10(2):144-67. Unique Identifier : AIDSLINE MED/97225324; Goldschmidt RH; Dong BJ; Family Practice Residency Program, San Francisco General Hospital, CA; 94110, USA.
Seroprevalence and coprevalence of HIV and HBsAg in Nigerian children with/without protein energy malnutrition.: Acta Trop. 1997 Apr 15;64(3-4):167-74. Unique Identifier : AIDSLINE MED/97261410; Akenami FO; Koskiniemi M; Ekanem EE; Bolarin DM; Vaheri A; Haartman Institute, Department of Virology, University of Helsinki,; Finland. Francis.Akenami@Helsinki.FI; In order to assess the seroprevalence and coprevalence of hepatitis-B surface antigen (HBsAg), human immunodeficiency virus-1 and -2 (HIV-1 and -2) antibodies in Nigerian children with/without protein energy malnutrition (PEM), we studied plasma specimens of 206 children with PEM and 200 apparently healthy reference c
[Molecular biology at the service of the daily medical virology. 2. Applications to virological diagnosis]: Ann Biol Clin (Paris). 1997 Mar-Apr;55(2):81-91. Unique Identifier : AIDSLINE MED/97324890; Wattre P; Service de virologie, CHRU, Institut Gernez-Rieux, Lille.; Molecular biology techniques are applied for the diagnosis of meningoencephalitis due to herpesviruses, enteroviruses or polyomaviruses, for the diagnosis of human cytomegalovirus , human parvovirus B19, varicella-zoster virus and rubella virus infections occurring during pregnancy,
[Pulmonary tuberculosis in 1996. Recent data and practical consequences for the anesthesiologist]: Ann Fr Anesth Reanim. 1996;15(7):1080-7. Unique Identifier : AIDSLINE MED/97324913; Veber B; Service de reanimation chirurgicale, hopital Charles-Nicolle, Rouen,; France.; Tuberculosis is one of the most widespread diseases, occurring in more than eight million persons, and about three million die annually of tuberculosis. In industrialized countries, the incidence has increased significantly over the last 10 years. HIV infection is a main factor leading to this increase. Outbreaks of n
Structure-based drug design: computational advances.: Annu Rev Pharmacol Toxicol. 1997;37:71-90. Unique Identifier : AIDSLINE MED/97277871; Marrone TJ; Briggs JM; McCammon JA; Department of Chemistry and Biochemistry, University of California San; Diego, La Jolla 92093-0365, USA.; Structure-based computational methods continue to enhance progress in the discovery and refinement of therapeutic agents. Several such methods and their applications are described. These include molecular visualization and molecular modeling, docking, fragment methods, 3-D database techniques, and free-energy perturba
Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract.: Biochem Biophys Res Commun. 1997 Apr 28;233(3):742-7. Unique Identifier : AIDSLINE MED/97312484; Tsukahara S; Suzuki J; Hiratou T; Takai K; Koyanagi Y; Yamamoto N; Takaku H; Department of Industrial Chemistry, Chiba Institute of Technology,; Japan.; We show the effects of triple-helix formation by assays of primer extension inhibition in vitro using two systems two-strand-system (FTFOs) or three-strand-system (TFOs) targeted to the polypurine tract (PPT) of HIV-1. The FTFOs were more effective than the TFOs. We found that the FTFOs containing phosphorothioate gro
Integration of HTLV-1 provirus into mouse transforming growth factor-alpha gene.: Biochem Biophys Res Commun. 1997 Apr 28;233(3):792-5. Unique Identifier : AIDSLINE MED/97312494; Fang J; Kushida S; Feng R; Tanaka M; Kikukawa H; Kawamura T; Uchida K; Miwa M; Department of Biochemistry and Molecular Oncology, University of; Tsukuba, Ibaraki, Japan.; Human T cell leukemia virus type 1 (HTLV-1) provirus integration was investigated in mice inoculated with MT-2 cells, a HTLV-1 producing human T-cell line. From spleen DNA derived from a MT-2 cell-injected mouse, we cloned a HTLV-1 integration site by ligation-mediated PCR. The nucleotide sequence showed that HTLV-1 p
[Progressive hearing loss in children with hearing aids]: Laryngorhinootologie. 1997 Mar;76(3):123-6. Unique Identifier : AIDSLINE MED/97280154; Streppel M; Betten T; von Wedel H; Eckel HE; Damm M; Klinik und Poliklinik fur Hals-Nasen-Ohrenheilkunde,; Kopf-Halschirurgie, Universitat Koln.; BACKGROUND: The possibility of hearing aid induced deterioration was first described in 1939 (Berry 1939, Holmgren 1939). Since then numerous studies discussed this problem controversely. However, it is undisputed that in cases of profound sensorineural hearing loss in childhood powerful hearing aids are necessary for
The Th1/Th2 paradigm.: Immunol Today. 1997 Jun;18(6):263-6. Unique Identifier : AIDSLINE MED/97334004; Romagnani S; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy. s.romagnani@mednuc2
Minimising the dosage-limiting toxicities of foscarnet induction therapy.: Drug Saf. 1997 Apr;16(4):258-66. Unique Identifier : AIDSLINE MED/97268230; Jayaweera DT; University of Miami School of Medicine, Florida, USA.; This article suggests ways to manage the dose-limiting adverse reactions caused by foscarnet so that this agent may be used with confidence as first-line therapy in patients with cytomegalovirus CMV ) disease. Foscarnet (triso
Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients.: AIDS. 1997 Mar 15;11(4):F29-33. Unique Identifier : AIDSLINE MED/97239094; Merry C; Barry MG; Mulcahy F; Ryan M; Heavey J; Tjia JF; Gibbons SE; Breckenridge AM; Back DJ; Department of Pharmacology and Therapeutics, University of Liverpool,; UK.; OBJECTIVE: The most important hepatic enzyme involved in the metabolism of protease inhibitors is cytochrome P450 3A4 CYP3A4). Ritonavir (RIT) is a potent inhibitor of CYP3A4 and inhibits saquinavir
Implications of HIV variability for transmission: scientific and policy issues. Expert Group of the Joint United Nations Programme on HIV/AIDS.: AIDS. 1997 Mar 15;11(4):UNAIDS1-15. Unique Identifier : AIDSLINE MED/97239127
HIV-1 and the thymus [editorial]: AIDS. 1997 Mar 15;11(4):403-14. Unique Identifier : AIDSLINE MED/97239095; Gaulton GN; Scobie JV; Rosenzweig M
Divergence of HIV-1 quasispecies in an epidemiologic cluster.: AIDS. 1997 Mar 15;11(4):415-22. Unique Identifier : AIDSLINE MED/97239096; Diaz RS; Zhang L; Busch MP; Mosley JW; Mayer A; Irwin Memorial Blood Centers, San Francisco, CA 94118, USA.; BACKGROUND: During treatment with blood components prepared from an HIV-infected donation, two recipients became infected in 1985. One recipient infected her sexual partner. OBJECTIVE: To evaluate the evolution of the originally-shared HIV-1 quasispecies in different human hosts over time, sequence data were obtained
Tumour necrosis factor c2 microsatellite allele is associated with the rate of HIV disease progression.: AIDS. 1997 Mar 15;11(4):423-8. Unique Identifier : AIDSLINE MED/97239097; Khoo SH; Pepper L; Snowden N; Hajeer AH; Vallely P; Wilkins EG; Mandal BK; Ollier WE; Department of Infectious Diseases, Monsall Unit, North Manchester; General Hospital, UK.; BACKGROUND: The rate of immunological deterioration and progression to AIDS differs markedly between HIV-positive individuals, and may be influenced by cofactors, HIV phenotype and host T-cell response. Tumour necrosis factor (TNF)-alpha and lymphotoxin stimulate HIV replication and may induce apoptosis of HIV-infecte
Timing of maternal-infant HIV transmission: associations between intrapartum factors and early polymerase chain reaction results. New York City Perinatal HIV Transmission Collaborative Study Group.: AIDS. 1997 Mar 15;11(4):429-35. Unique Identifier : AIDSLINE MED/97239098; Kuhn L; Abrams EJ; Matheson PB; Thomas PA; Lambert G; Bamji M; Greenberg B; Steketee RW; Thea DM; Sergievsky Center, Columbia University, New York, NY 10032, USA.; OBJECTIVE: To investigate the hypothesis that labour and delivery events, perinatal characteristics, and maternal factors are only associated with intrapartum HIV transmission, and not with intrauterine HIV transmission. METHODS: In the New York City Perinatal HIV Transmission Collaborative Study 276 infants of HIV-in
The effect of maternal viral load on the risk of perinatal transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group.: AIDS. 1997 Mar 15;11(4):437-44. Unique Identifier : AIDSLINE MED/97239099; Thea DM; Steketee RW; Pliner V; Bornschlegel K; Brown T; Orloff S; Matheson PB; Abrams EJ; Bamji M; Lambert G; Schoenbaum EA; Thomas PA; Heagarty M; Kalish ML; Medical and Health Research Association, New York, New York, USA.; OBJECTIVE: To determine the effect of maternal viral load at delivery on the risk of perinatal transmission of HIV-1. DESIGN: A nested case-control study within a prospectively followed cohort of HIV-1-infected pregnant women and their infants. SETTING: The multicenter New York City Perinatal HIV Transmission Collabor
Serological and virological characterization of HIV-1 group O infection in Cameroon.: AIDS. 1997 Mar 15;11(4):445-53. Unique Identifier : AIDSLINE MED/97239100; Mauclere P; Loussert-Ajaka I; Damond F; Fagot P; Souquieres S; Monny Lobe M; Mbopi Keou FX; Barre-Sinoussi F; Saragosti S; Brun-Vezinet F; Simon F; Centre Pasteur du Cameroun, National Public Health and Reference; Laboratory Yaounde, Cameroun.; OBJECTIVES: To study the presence of HIV-1 group O infection among HIV-infected people in Cameroon and to further characterize the HIV-1 group O infections. DESIGN AND METHODS: During a 2-year survey (1994-1995), all samples tested positive in screening methods in the National Re
Site of disease and opportunistic infection predict survival in HIV-associated tuberculosis.: AIDS. 1997 Mar 15;11(4):455-60. Unique Identifier : AIDSLINE MED/97239101; Whalen C; Horsburgh CR Jr; Hom D; Lahart C; Simberkoff M; Ellner J; Department of Epidemiology and Biostatistics, University Hospitals of; Cleveland, USA.; OBJECTIVE: Infection with HIV adversely affects survival in patients with tuberculosis (TB), even when TB is effectively treated. The aim of this study was to identify the determinants of survival in HIV-associated TB. DESIGN: Retrospective cohort study. SETTING: Four US academic medical centers. PATIENTS: An inceptio
Antiretroviral treatment and progression to AIDS in HIV seroconverters from different risk groups. HIV Italian Seroconversion Study.: AIDS. 1997 Mar 15;11(4):461-7. Unique Identifier : AIDSLINE MED/97239102; Dorrucci M; Pezzotti P; Phillips AN; Alliegro MB; Rezza G; Centro Operativo AIDS, Laboratory of Epidemiology and Biostatistics,; Istituto superiore di Sanita, Rome, Italy.; OBJECTIVES: To evaluate the association between time since initiation of pre-AIDS antiretroviral therapy [mainly with zidovudine (ZDV)] and AIDS-free survival in a cohort of HIV seroconverters, and to assess possible differences in this association and in the use of antiretroviral therapy by HIV exposure group. DESIGN
Three-drug combination of MKC-442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV-1.: AIDS. 1997 Mar 15;11(4):469-75. Unique Identifier : AIDSLINE MED/97239103; Piras G; Nakade K; Yuasa S; Baba M; Division of Human Retroviruses, Faculty of Medicine, Kagoshima; University, Japan.; OBJECTIVES: MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil), a potent non-nucleoside reverse transcriptase inhibitor, is a promising candidate for the treatment of HIV-1 infection and is now undergoing clinical trials. We studied the in vitro activity of MKC-442 against HIV-1 replication in a three-drug combinatio
Reductions in HIV-1 disease progression for zidovudine/lamivudine relative to control treatments: a meta-analysis of controlled trials.: AIDS. 1997 Mar 15;11(4):477-83. Unique Identifier : AIDSLINE MED/97239104; Staszewski S; Hill AM; Bartlett J; Eron JJ; Katlama C; Johnson J; Sawyer W; McDade H; Goethe-Universitat, Frankfurt, Germany.; OBJECTIVES: Four randomized double-blind trials have demonstrated that zidovudine/lamivudine (ZDV/ 3TC ) reduces HIV RNA and raises CD4 counts relative to control treatments (ZDV or ZDV/zalcitabine
Change in circulating levels of the chemokines macrophage inflammatory proteins 1 alpha and 11 beta, RANTES, monocyte chemotactic protein-1 and interleukin-16 following treatment of severely immunodeficient HIV-infected individuals with indinavir.: AIDS. 1997 Mar 15;11(4):485-91. Unique Identifier : AIDSLINE MED/97239105; Bisset LR; Rothen M; Joller-Jemelka HI; Dubs RW; Grob PJ; Opravil M; Division of Clinical Immunology, University Hospital, Zurich,; Switzerland.; OBJECTIVE: To evaluate the in vivo relationship between HIV replication and circulating levels of the chemokines macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, RANTES (acronym for Regulated upon Activation, Normal T-cell Expressed and presumably Secreted), interleukin (IL)-16 and monocyte chemotactic prote
Geographical distribution of HIV-1 group O viruses in Africa.: AIDS. 1997 Mar 15;11(4):493-8. Unique Identifier : AIDSLINE MED/97239106; Peeters M; Gueye A; Mboup S; Bibollet-Ruche F; Ekaza E; Mulanga C; Ouedrago R; Gandji R; Mpele P; Dibanga G; Koumare B; Saidou M; Esu-Williams E; Lombart JP; Badombena W; Luo N; Vanden Haesevelde M; Delaporte E; Laboratoire Retrovirus, ORSTOM, Montpellier, France.; OBJECTIVE: To determine to what extent HIV-1 group O strains are present in different African countries. MATERIALS AND METHODS: A total of 14,682 samples of sera from a range of patients from 12 different African countries were tested. All the sera were tested with an enzyme-linked immunosorbent assay (ELISA) using a
The spread of AIDS and the re-emergence of tuberculosis in Catalonia, Spain.: AIDS. 1997 Mar 15;11(4):499-505. Unique Identifier : AIDSLINE MED/97239107; Vall Mayans M; Maguire A; Miret M; Alcaide J; Parron I; Casabona J; Department of Health and Social Security, University Hospital Germans; Trias i Pujol, Badalona, Spain.; OBJECTIVE: To assess the impact of HIV/AIDS on the incidence of tuberculosis (TB) and to analyse the determinants of TB presenting as the first indicative disease of AIDS. DESIGN: Analysis of TB and AIDS surveillance data. SETTING: Catalonia, north-east Spain . PATIENTS: Two separate
Psychopathology in male and female HIV-positive and negative injecting drug users: longitudinal course over 3 years.: AIDS. 1997 Mar 15;11(4):507-15. Unique Identifier : AIDSLINE MED/97239108; Rabkin JG; Johnson J; Lin SH; Lipsitz JD; Remien RH; Williams JB; Gorman JM; Department of Psychiatry, College of Physicians and Surgeons, Columbia; University, New York, New York, USA.; OBJECTIVE: To evaluate the impact of HIV illness on psychiatric and psychosocial functioning over 3 years in a sample of male and female HIV-positive injecting drug users (IDU), with a comparison group of HIV-negative male and female IDU. DESIGN: As part of a multidisciplinary study, 121 men (69 HIV-positive, 52 HIV-n
Predictors of cytomegalovirus disease, natural history and autopsy findings in a cohort of patients with AIDS.: AIDS. 1997 Mar 15;11(4):517-24. Unique Identifier : AIDSLINE MED/97239109; d'Arminio Monforte A; Mainini F; Testa L; Vago L; Balotta L; Nebuloni M; Antinori S; Bini T; Moroni M; Clinic of Infectious Diseases, L. Sacco Hospital, University of Milan,; Italy.; OBJECTIVE: To identify the predictors of acquiring cytomegalovirus ( CMV ) disease, and to describe natural history, therapeutic management and autopsy findings in affected patients. DESIGN: Observational study of a consecutive
Survival of European patients with Kaposi's sarcoma as AIDS-defining condition during the first decade of AIDS. AIDS in Europe Study Group.: AIDS. 1997 Mar 15;11(4):525-31. Unique Identifier : AIDSLINE MED/97239110; Hermans P; Lundgren J; Sommereijns B; Katlama C; Chiesi A; Goebel FD; Gonzales-Lahoz J; Proenza R; Barton SE; Pedersen C; Clumeck N; Saint-Pierre University Hospital, Brussels, Belgium.; OBJECTIVES: To determine whether the survival of patients with Kaposi s sarcoma as first manifestation of AIDS has changed between 1979 and 1989; and to define whether prognosis factors could be identified. PATIENTS AND METHODS: This is a multicentric retrospective cohort study from 52 centers in 17 European countries
Increased T-helper-type 2 cytokine production in chronic HIV infection is due to interleukin (IL)-13 rather than IL-4 [letter]: AIDS. 1997 Mar 15;11(4):533-4. Unique Identifier : AIDSLINE MED/97239111; Zou W; Dulioust A; Fior R; Durand-Gasselin I; Boue F; Galanaud P; Emilie D
HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase [letter]: AIDS. 1997 Mar 15;11(4):534-6. Unique Identifier : AIDSLINE MED/97239112; Amacker M; Hottiger M; Mossi R; Hubscher U
Identification of a novel HLA-B*2705-restricted cytotoxic T-lymphocyte epitope within a conserved region of HIV-1 Nef [letter]: AIDS. 1997 Mar 15;11(4):536-8. Unique Identifier : AIDSLINE MED/97239113; Goulder PJ; Edwards A; Phillips RE; McMichael AJ
Interleukin-16 does not suppress HIV-1 replication in naturally infected peripheral blood mononuclear cells [letter]: AIDS. 1997 Mar 15;11(4):538-9. Unique Identifier : AIDSLINE MED/97239114; Gao M; Tsuchie H; Detorio MA; Hossain MM; Owatari S; Zhang J; Taniguchi K; Nishimoto A; Shirono H; Koga J; Takata N; Matsumoto T; Yoshizaki K; Kurimura T
HIV-1 primary infection in two pairs of patients: difference in variants transmitted and clinical follow-up [letter]: AIDS. 1997 Mar 15;11(4):539-42. Unique Identifier : AIDSLINE MED/97239115; Innocenti-Francillard P; Brengel-Pesce K; Morand P; Ounanian-Paraz A; Leclercq P; Gruters R; Seigneurin JM
Threshold of HIV-1 copy numbers for vertical transmission [letter]: AIDS. 1997 Mar 15;11(4):542-3. Unique Identifier : AIDSLINE MED/97239116; Zollner B; Feucht HH; Helling-Giese G; Mattner UM; Schartl W; Polywka S; Laufs R
Shedding of HIV-1 in semen during primary infection [letter]: AIDS. 1997 Mar 15;11(4):543-5. Unique Identifier : AIDSLINE MED/97239117; Dyer JR; Gilliam BL; Eron JJ Jr; Cohen MS; Fiscus SA; Vernazza PL
Increase of HIV seroprevalence among professional prostitutes in Italy [letter]: AIDS. 1997 Mar 15;11(4):545-6. Unique Identifier : AIDSLINE MED/97239118; Spina M; Mancuso S; Sinicco A; Vaccher E; Traina C; Di Fabrizio N; de Lalla F; Tirelli U
Condom use in two rural districts of Lira and Soroti in Uganda [letter]: AIDS. 1997 Mar 15;11(4):546-8. Unique Identifier : AIDSLINE MED/97239119; Opio AA; Asiimwe-Okiror G; Musinguzi J; Kaweesa-Kisitu D; Madraa E; Nsubuga P
Adding saquinavir to stavudine in patients with advanced HIV-1 infection [letter]: AIDS. 1997 Mar 15;11(4):548. Unique Identifier : AIDSLINE MED/97239120; Rutschmann OT; Kaiser L; Perrin L; Fathi M; Hirschel BJ
Pneumocystis carinii hominis sequencing to study hypothetical person-to-person transmission [letter]: AIDS. 1997 Mar 15;11(4):549. Unique Identifier : AIDSLINE MED/97239121; Latouche S; Poirot JL; Maury E; Bertrand V; Roux P
Rising incidence of human T-cell leukaemia/lymphoma virus type II in Spanish drug users [letter]: AIDS. 1997 Mar 15;11(4):549-50. Unique Identifier : AIDSLINE MED/97239122; Soriano V; Martinez-Zapico R; Gutierrez M; Guerra A; Dronda F
Miller Fisher syndrome in a patient with HIV infection [letter]: AIDS. 1997 Mar 15;11(4):550-1. Unique Identifier : AIDSLINE MED/97239123; Arranz Caso JA; Martinez R; Cabrera F; Tejeiro J
Early foscarnet failure in herpes simplex virus infection in a patient with AIDS [letter]: AIDS. 1997 Mar 15;11(4):552-3. Unique Identifier : AIDSLINE MED/97239124; Segal BH; Engler HD; Little R; Wilson WH; Freifeld AG; Chanock SJ
Fulminant hepatic failure caused by microsporidial infection in a patient with AIDS [letter]: AIDS. 1997 Mar 15;11(4):553-4. Unique Identifier : AIDSLINE MED/97239125; Sheth SG; Bates C; Federman M; Chopra S
AIDS education programme in Colombian medical schools: training the teachers [letter]: AIDS. 1997 Mar 15;11(4):554-5. Unique Identifier : AIDSLINE MED/97239126; Garcia-Bernard R; Shor-Posner G; Klaskala W; Castro J; Baum M
Expression of foreign proteins on the surface of Autographa californica nuclear polyhedrosis virus.: Biotechniques. 1997 Apr;22(4):730-5. Unique Identifier : AIDSLINE MED/97259524; Grabherr R; Ernst W; Doblhoff-Dier O; Sara M; Katinger H; University of Agriculture, Food Science and Forestry, Vienna, Austria.; Based on the method of direct cloning into the baculovirus genome by linearizing and re-ligation in presence of the target insert, we designed viral constructs that express foreign genes on the surface of baculovirus particles. We chose the glycosylated envelope protein gp41 of human immunodeficiency virus type 1 HIV-
Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness.: Am J Respir Cell Mol Biol. 1997 Jun;16(6):674-82. Unique Identifier : AIDSLINE MED/97334803; Hamelmann E; Oshiba A; Schwarze J; Bradley K; Loader J; Larsen GL; Gelfand EW; Department of Pediatrics, National Jewish Medical and Research Center,; Denver, Colorado 80206, USA.; The mechanisms underlying the development of airway hyperresponsiveness are not fully delineated. We addressed this question by studying the effects of passive sensitization with anti-OVA IgE on the development of altered airway responsiveness AR) following local challenge with OVA in normal and athymic mice. Both nor
An interactive Web site providing major histocompatibility ligand predictions: application to HIV research.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):529-31. Unique Identifier : AIDSLINE MED/97281562; De Groot AS; Jesdale BM; Szu E; Schafer JR; Chicz RM; Deocampo G; TB/HIV Research Laboratory, Brown University School of Medicine,; Providence, Rhode Island 02912, USA.; EpiMatrix/HIV, a tool that is currently available on the World Wide Web, enables researchers to screen HIV proteins for potential MHC ligands. We have performed a comparison of EpiMatrix predictions to 158 published allotype-specific HLA-associated peptides (MHC ligands) derived from 133 proteins. The top 10 ranked Ep
Wild-type and mutant HIV type 1 nucleocapsid proteins increase the proportion of long cDNA transcripts by viral reverse transcriptase.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):533-43. Unique Identifier : AIDSLINE MED/97281563; Drummond JE; Mounts P; Gorelick RJ; Casas-Finet JR; Bosche WJ; Henderson LE; Waters DJ; Arthur LO; NCI-Frederick Cancer Research and Development Center, SAIC Frederick,; Maryland 21702, USA.; HIV-1 nucleocapsid, p7, contains two retroviral zinc fingers, which are both necessary for efficient packaging of genomic RNA and infectivity. The nucleocapsid protein is bound tightly to genomic RNA in the mature virion. In this study, the effect of p7 on polymerization of nascent cDNA by viral reverse transcriptase
The multiple inhibitory mechanisms of GEM 91, a gag antisense phosphorothioate oligonucleotide, for human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):545-54. Unique Identifier : AIDSLINE MED/97281564; Yamaguchi K; Papp B; Zhang D; Ali AN; Agrawal S; Byrn RA; Division of Hematology/Oncology, Beth Israel Deaconess Medical Center,; Harvard Medical School, Boston, Massachusetts 02215, USA.; GEM 91 (gene expression modulator) is a 25-mer oligonucleotide phosphorothioate complementary to the gag initiation site of HIV-1. GEM 91 has been studied in various in vitro cell culture models to examine inhibitory effects on different stages of HIV-1 replication. Experiments were focused on the binding of virions t
Correlation between changes in plasma HIV RNA levels and in plasma infectivity in response to antiretroviral therapy.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):555-61. Unique Identifier : AIDSLINE MED/97281565; Andreoni M; Sarmati L; Ercoli L; Nicastri E; Giannini G; Galluzzo C; Pirillo MF; Vella S; Department of Public Health and Cellular Biology, University of Tor; Vergata, Rome, Italy.; We evaluated the degree of correlation between the variation of different HIV-1 viral load measures in response to antiretroviral therapy. A quantitative reverse transcriptase polymerase chain reaction (RT-PCR) for plasma HIV-RNA, and HIV plasma infectivity titration, were performed on prospective samples obtained fro
Clonal selection of HIV type 1 variants associated with resistance to foscarnet in vitro: confirmation by molecular evolutionary analysis.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):563-73. Unique Identifier : AIDSLINE MED/97281566; Nakano T; Morozumi H; Inuzuka S; Nagata M; Taguchi Y; Mizokami M; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, Japan.; Foscarnet (trisodium phosphonoformate, PFA) is an effective inhibitor of retroviral reverse transcriptase (RT) and is known to block the replication of human immunodeficiency virus type 1 HIV-1). In this article we analyzed the evolutionary process in generating HIV-1 strains related to drug resistance, using PFA as a
Recombinant human monoclonal antibody IgG1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):575-82. Unique Identifier : AIDSLINE MED/97281567; Kessler JA 2nd; McKenna PM; Emini EA; Chan CP; Patel MD; Gupta SK; Mark GE 3rd; Barbas CF 3rd; Burton DR; Conley AJ; Department of Antiviral Research, Merck Research Laboratories, West; Point, Pennsylvania 19486, USA.; The CD4-binding domain of human immunodeficiency virus type 1 HIV-1) gp120 elicits antibodies that are present in infected human sera. Monoclonal antibodies that recognize the HIV-1 gp120 CD4-binding domain have been isolated. Some of these antibodies can neutralize laboratory-adapted strains of HIV-1 and probably med
Characterization and titration of an HIV type 1 subtype E chimpanzee challenge stock.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):583-91. Unique Identifier : AIDSLINE MED/97281568; Barre-Sinoussi F; Georges-Courbot MC; Fultz PN; Nguyen Thi Tuyet H; Muchmore E; Saragosti S; Dubreuil G; Georges A; van der Ryst E; Girard M; Institut Pasteur, Paris, France.; A subtype E human immunodeficiency virus type 1 (HIV-1) isolate from the Central African Republic (E/90CR402) was adapted to growth on chimpanzee peripheral blood mononuclear cells (PBMCs) by cocultivation of irradiated, infected human PBMCs with chimpanzee PBMCs. T
Live attenuated SIV vaccines are not effective in a postexposure vaccination model.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):593-9. Unique Identifier : AIDSLINE MED/97281569; Linhart H; Gundlach BR; Sopper S; Dittmer U; Matz-Rensing K; Kuhn EM; Muller J; Hunsmann G; Stahl-Hennig C; Uberla K; Institute of Clinical and Molecular Virology, University of; Erlangen-Nurnberg, Germany.; Live attenuated simian immunodeficiency virus (SIV) vaccines, like nef deletion mutants, have been the most effective vaccines tested in the SIV/macaque model so far. The efficacy of live attenuated SIV vaccines in therapeutic vaccination and postexposure prophylaxis has not been determined. Inoculation of macaques wi
Reverse transcriptase and corresponding activity-blocking antibody for monitoring SIVsm infection in macaques.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):601-10. Unique Identifier : AIDSLINE MED/97281570; Ekstrand DH; Bottiger D; Andersson H; Gronowitz JS; Clas FR; Department of Medical Genetics, Uppsala University, BMC, Sweden.; A nonradioactive reverse transcriptase (RT) assay was used to measure RT activity in serum during the viremia peak associated with primary infection and for measuring the generation and maintenance of RT activity-blocking antibody (RTb-ab) titers during and after seroconversion in SIV-infected macaques. The RT assay w
Selective thymocyte depletion and immunoglobulin coating in the thymus of cats infected with feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):611-20. Unique Identifier : AIDSLINE MED/97281571; Orandle MS; Papadi GP; Bubenik LJ; Dailey CI; Johnson CM; Department of Pathobiology, University of Florida, Gainesville 32610,; USA.; Thymus alterations associated with feline immunodeficiency virus FIV), an AIDS animal model, were investigated by measuring phenotypic composition of thymocytes, structure of thymic epithelial cells, and transcription of viral RNA in the thymus of FIV-infected juvenile kittens. These kittens either acquired infection
Phylogenetic analysis of HIV type 2 in Ghana and intrasubtype recombination in HIV type 2.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):621-3. Unique Identifier : AIDSLINE MED/97281572; Takehisa J; Osei-Kwasi M; Ayisi NK; Hishida O; Miura T; Igarashi T; Brandful J; Ampofo W; Netty VB; Mensah M; Yamashita M; Ido E; Hayami M; Laboratory of Pathogenic Virus, Kyoto University, Japan.
First human immunodeficiency virus type 1 sequences in the V3 region, nef and vpr genes from Papua New Guinea.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):625-7. Unique Identifier : AIDSLINE MED/97281573; Dwyer DE; Ge YC; Wang B; Bolton WV; McCormack JG; Cunningham AL; Saksena NK; Retroviral Genetics Laboratory, Westmead Institutes of Health; Research, CIDM, Westmead Hospital, Australia.
Selected nucleotide sequence of the pol gene of the monocytotropic strain HIV type 1 BaL.: AIDS Res Hum Retroviruses. 1997 May 1;13(7):629-32. Unique Identifier : AIDSLINE MED/97281574; Cenci A; Perno CF; Menzo S; Clementi M; Erba F; Tavazzi B; Di Pierro D; Aquaro S; Calio R; Dipartimento di Medicina Sperimentale e Scienze Biochimiche,; Universita di Roma Tor Vergata, Italy.
Substituent effects on the enantioselective retention of anti-HIV 5-aryl-delta 2-1,2,4-oxadiazolines on R,R-DACH-DNB chiral stationary phase.: Chirality. 1996;8(8):556-66. Unique Identifier : AIDSLINE MED/97177749; Altomare C; Cellamare S; Carotti A; Barreca ML; Chimirri A; Monforte AM; Gasparrini F; Villani C; Cirilli M; Mazza F; Dipartimento Farmaco-Chimico, Universita di Bari, Italy.; A series of racemic 3-phenyl-4-(1-adamantyl)-5-X-phenyl- delta 2-1,2,4-oxadiazo lines (PAdOx) were directly resolved by HPLC using a Pirkle-type stationary phase containing N,N -(3,5-dinitrobenzoyl)-1(R),2(R)-diaminocyclohexane as chiral selector. The more retained enantiomers have S configuration, as demonstrated by
Differential expression of nucleoskeleton- and cytoskeleton-associated proteins in Burkitt lymphoma-derived and Epstein-Barr virus-immortalized lymphoblastoid cell lines.: Cell Growth Differ. 1997 May;8(5):599-609. Unique Identifier : AIDSLINE MED/97294027; Szekely L; Pokrovskaja K; Klein G; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Mouse monoclonal antibodies raised against nuclear bodies isolated from an EBV-immortalized lymphoblastoid cell line (LCL) known to contain several viral and cellular proteins (Jiang et al., Exp. Cell Res., 197: 314-318, 1991; Szekely et al., J. Gen. Virol., 76: 2423-2432, 1995; Szekely et al., J. Virol., 70: 2562-256
Antenatal testing for HIV: to opt in or opt out, that is the question [letter; comment]: Br J Obstet Gynaecol. 1997 Jun;104(6):758. Unique Identifier : AIDSLINE MED/97341566; MacDonagh SE; Mercey D; Kennedy J; Blott M
Structure-based thermodynamic analysis of HIV-1 protease inhibitors.: Biochemistry. 1997 Jun 3;36(22):6588-96. Unique Identifier : AIDSLINE MED/97327471; Bardi JS; Luque I; Freire E; Department of Biology and Biocalorimetry Center, The Johns Hopkins; University, Baltimore, Maryland 21218, USA.; A structural parametrization of the binding and folding energetics previously developed in this laboratory accounts quantitatively for the binding of 13 HIV-1 protease inhibitors for which high-resolution structures are available (A77003, A78791, A76928, A74704, A76
Psychosocial characteristics of HIV-infected adolescents in New Orleans [letter]: J Adolesc Health. 1997 Apr;20(4):258. Unique Identifier : AIDSLINE MED/97253284; Kissinger P; Fuller C; Clark RA; Abdalian SE
Interferon-gamma expression in macaque lymph nodes during primary infection with simian immunodeficiency virus.: Cytokine. 1996 Nov;8(11):844-52. Unique Identifier : AIDSLINE MED/97199106; Khatissian E; Monceaux V; Cumont MC; Montagnier L; Hurtrel B; Chakrabarti L; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; Simian immunodeficiency virus (SIV) replication is rapidly downregulated in the lymph nodes (LN) of rhesus macaques after the acute stage of primary infection. The aim of this study was to evaluate a possible role of interferon-gamma (IFN-gamma) in the control of SIV replication. IFN-gamma expression was analysed by i
[Effect of L-lysine-alpha-oxidase on the synthesis of cell proteins, targets of autoimmune pathology in HIV infection]: Biull Eksp Biol Med. 1997 Jan;123(1):36-8. Unique Identifier : AIDSLINE MED/97210977; Berezov TT; Zverev VV; Zaitsev IZ; Alekseev SB
Hematopoietic potential and retroviral transduction of CD34+ Thy-1+ peripheral blood stem cells from asymptomatic human immunodeficiency virus type-1-infected individuals mobilized with granulocyte colony-stimulating factor.: Blood. 1997 Jun 15;89(12):4299-306. Unique Identifier : AIDSLINE MED/97335957; Junker U; Moon JJ; Kalfoglou CS; Sniecinski I; Forman SJ; Zaia JA; Kaneshima H; Bohnlein E; Progenesys Program, Systemix Inc, Palo Alto, CA 94304, USA.; The potential of hematopoietic stem cells (HSCs) from human immunodeficiency virus type-1 (HIV-1)-infected individuals, eg, self-renewal and multilineage differentiative capacity, might be perturbed due to the underlying disease. In this study, we assessed the HSC activity in the CD34+ Thy-1+ cell population of periph
Pathological and epidemiological aspects of skin lesions in histoplasmosis. Observations in an AIDS patient and badgers outside endemic areas of histoplasmosis.: Zentralbl Bakteriol. 1997 Apr;285(4):531-9. Unique Identifier : AIDSLINE MED/97290159; Grosse G; Staib F; Rapp J; Rang H; Heise W; Kaufman L; Institut fur Pathologie, Auguste-Viktoria-Krankenhaus, Berlin,; Germany.; As a consequence of HIV infection, histoplasmosis is increasingly occurring as an opportunistic infection with a systemic course outside histoplasmosis-endemic areas, e.g. in Europe. Accordingly, questions concerning the epidemiology of this mycosis arise. Two incidents involving histoplasmosis in man and badgers with
I.v. access options for AIDS patients with cytomegalovirus disease.: Br J Nurs. 1997 May 22-Jun 11;6(10):543-6, 548, 550-3. Unique Identifier : AIDSLINE MED/97341261; Sargent J; Nixon E; Community Liaison Team, St. Mary's Paddington.; In view of changes over the past 2 years in the intravenous i.v.) management of patients with AIDS and cytomegalovirus ( CMV ) disease, a small study was carried out at the Kobler Clinic, an HIV treatment centre in London, to e
AIDS mania.: J Neuropsychiatry Clin Neurosci. 1997 Spring;9(2):277-9. Unique Identifier : AIDSLINE MED/97289186; Lyketsos CG; Schwartz J; Fishman M; Treisman G; AIDS Psychiatry Service and Neuropsychiatry and Memory Group, Johns; Hopkins University, Baltimore, Maryland 21287, USA.; Twenty patients with HIV infection and mania were grouped according to whether their first manic episode occurred when CD4 count was or = 200 (early onset). The late-onset patients were less likely to have personal or family histories of mood disorder and more likely to have
A SHOT in the arm for safer blood transfusion [editorial]: BMJ. 1996 Nov 16;313(7067):1221-2. Unique Identifier : AIDSLINE MED/97093560; Williamson LM; Heptonstall J; Soldan K
Healthy sexual lifestyle should be emphasised when negative results of HIV tests are given [letter; comment]: BMJ. 1996 Nov 16;313(7067):1259. Unique Identifier : AIDSLINE MED/97093591; Curless E
In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid.: Biol Pharm Bull. 1997 Feb;20(2):175-80. Unique Identifier : AIDSLINE MED/97210953; Komai T; Yagi R; Suzuki-Sunagawa H; Sakurai M; Higashida S; Sugano M; Handa H; Mohri H; Yasuoka A; Oka S; Yabe Y; Nishigaki T; Kimura S; Shimada K; Biological Research, Laboratory, Sankyo Co., Ltd., Tokyo, Japan.; In a series of compounds containing 2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), a transitionstate mimetic, R-87366:(2S,3S)-3-[N-(quinoxaline-2-carbonyl)-L-asparaginyl]amino- 2-hydroxy-4-phenylbutanoyl-L-proline tert-butylamide, was found to be a potent human immunodeficiency virus protease inhibitor Ki val
Isolation of type 1 and type 2 cloned mite allergen-specific T cells from an asthmatic child.: Pediatr Allergy Immunol. 1996 Nov;7(4):193-8. Unique Identifier : AIDSLINE MED/97295751; Chiang BL; Ding HJ; Chou CC; Hsieh KH; Department of Pediatrics, National Taiwan University College of; Medicine, Taipei, R.O.C.; Allergen-specific T cells have been thought to play a central role in the pathogenesis of asthma. It has been well documented that allergen-specific T cells derived from atopic patients are predominantly of type 2 T helper cell pattern. However, allergen-specific T cells derived in nonatopic normals are of type 1 in c
Parent and adolescent perceived need for parental consent involving research with minors.: Arch Pediatr Adolesc Med. 1997 Jun;151(6):603-7. Unique Identifier : AIDSLINE MED/97336496; Sikand A; Schubiner H; Simpson PM; Division of Adolescent Medicine, Children's Hospital of Michigan,; Wayne State University School of Medicine, Detroit, USA.; OBJECTIVE: To assess parents and adolescents perceived need for parental consent for minor adolescents to participate in minimal risk research studies based on procedural invasiveness (anonymous surveys, interviews, and blood or urine testing) and sensitivity of the topics (sexuality, drug and alcohol use, and sexua
Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when.: J Chromatogr B Biomed Appl. 1997 Feb 7;689(1):91-104. Unique Identifier : AIDSLINE MED/97215120; Fried K; Wainer IW; Department of Oncology, McGill University, Montreal General Hospital,; Que, Canada.; The application of stereoselective chromatographic techniques to bioanalytical problems has become a routine procedure. However, this approach is not always straightforward; particularly when the separation involves chromatographic chiral stationary phases. Matrix interferences and more importantly, overlapping metabo
Neuroimaging of AIDS. I. Central nervous system toxoplasmosis.: Neuroimaging Clin N Am. 1997 May;7(2):171-86. Unique Identifier : AIDSLINE MED/97268960; Ramsey RG;