HIV-1 infection in a population-based twin sample. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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HIV-1 infection in a population-based twin sample.

Pediatr AIDS HIV Infect. 1997 Apr;8(2):114-9. Unique Identifier : AIDSLINE MED/97323597
Krasinski K; Turner BJ; Hauck WW; Fanning TR; New York University Medical Center-Bellevue Hospital Center, New York,; USA.

Abstract: OBJECTIVE: To examine factors associated with perinatal HIV-1 transmission among twins. METHODS: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard RH) of transmission. RESULTS: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. CONCLUSIONS: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal viral load is likely to have a greater impact than modifying delivery factors.
Keywords: *Disease Transmission, Vertical *Diseases in Twins *HIV Infections/TRANSMISSION *Pregnancy Complications, Infectious/DIAGNOSIS *Pregnancy, MultipleKWDdiseasetransmission,verticalKWDdiseasesintwinsKWDhivinfections/transmissionKWDpregnancycomplications,infectious/diagnosisKWDpregnancy,multiple
971030
M97A1315

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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