HIV-infected children with hemophilia: one- and two-year follow-up of neuropsychological functioning. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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HIV-infected children with hemophilia: one- and two-year follow-up of neuropsychological functioning.

Pediatr AIDS HIV Infect. 1997 Apr;8(2):91-7. Unique Identifier : AIDSLINE MED/97323593
Hooper SR; Whitt JK; Tennison MB; Burchinal M; Gold SH; Hall CD; Department of Psychiatry, University of North Carolina, Chapel Hill,; USA.

Abstract: This report describes the absence of neuropsychologic change observed over a 2-year period for 25 HIV-seropositive (HIV+) children and adolescents with hemophilia and 33 HIV-seronegative HIV-) controls. Efforts were made to match the groups on the basis of chronological age, race, and hemophilia severity. The baseline evaluation included blinded neuropsychologic measurement of motor, attention, language, visual processing, memory, and general intelligence. HIV+ and HIV-group means did not differ at baseline on any neuropsychologic domain, and this trend continued at the 2-year follow-up. Mixed models analyses did not indicate that the HIV+ group performed more poorly than the HIV- group on any of the neuropsychological domains, nor did they show different patterns of change over time on these variables for the HIV+ group. Consistent with emergent findings, it continues to be premature to attribute subtle neuropsychologic deficits in seropositive children with hemophilia directly to the central nervous system (CNS) effects of HIV infection.
Keywords: *AIDS Dementia Complex/DIAGNOSIS *Blood Component Transfusion/ADVERSE EFFECTS *Hemophilia/THERAPY *HIV Seropositivity/DIAGNOSIS *Neuropsychological TestsKWDaidsdementiacomplex/diagnosisKWDbloodcomponenttransfusion/adverseeffectsKWDhemophilia/therapyKWDhivseropositivity/diagnosisKWDneuropsychologicaltests
971030
M97A1310

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