1997

SORAN news.: Blantyre [Malawi] : SORAN, v Unique Identifier : AIDSLINE MED/9702645
Gutachten zu fachwissenschaftlichen Fragen der Einstufung von Arbeiten mit dem HIV-Virus in die Sicherheitsstufe S3.: Freiburg : Oko-Institut e.V., [1993] 76 p Unique Identifier : AIDSLINE MED/9704377; Jager M
1. Turkiye AIDS Kongresi (Uluslararasi katki ile), 12-15 Ocak 1993.: Istanbul : Istanbul Tip Fakultesi, [1993?] xii, 158 p Unique Identifier : AIDSLINE MED/9601958
Annual report of AIDS in Canada. 1994. Surveillance: Ottawa, Ont. : Bureau of HIV/AIDS and STD, Laboratory Centre for Disease Control, Health Canada, [1995] 1 v Unique Identifier : AIDSLINE MED/9611411
Participatory management in coping with AIDS.: [Dar es Salaam] Tanzania : ParProSo Group, 1994 vi, 116 p. : ill Unique Identifier : AIDSLINE MED/9706955
Ninfee alla deriva : aspetti psicosociali dell'AIDS e delle altre malattie a trasmissione sessuale.: Bologna : Pitagora editrice, c1995 vii, 149 p. : ill Unique Identifier : AIDSLINE MED/9708050; Lazzari C
HIV focus : a newsletter reporting on the Ryan White Title III(b) Program. Issue 1 (Aug. 1995)- of Programs for Special Populations: Bethesda, MD : The Division, [1995- v. : ill., ports Unique Identifier : AIDSLINE MED/9612110
Bad blood : crisis in the American Red Cross.: New York, NY : Kensington Books, c1996 xiv, 289 p. : ill., ports Unique Identifier : AIDSLINE MED/9707274; Reitman J
AIDS in Canada : annual report on AIDS in Canada. Dec. 1996- Surveillance: Ottawa, Ont. : Division of Hiv/AIDS Surveillance, Bureau of HIV/AIDS and STD, Laboratory Centre for Disease Control, Health Canada, c1996- v Unique Identifier : AIDSLINE MED/9705863
Legislative survey of state confidentiality laws, with specific emphasis on HIV and immunization : final report presented to the U.S. Centers for Disease Control and Prevention, the Council of State and Territorial Epidemiologists, the Task Force for Child Survival and Development, Carter Presidential Center.: 1996 iii, 172, 346 p Unique Identifier : AIDSLINE MED/9707914; Gostin LO; Lazzarini Z; Flaherty KM
Stopping AIDS : AIDS/HIV education and the mass media in Europe.: London ; New York : Longman, 1996 viii, 263 p. : ill Unique Identifier : AIDSLINE MED/9709772; Wellings K; Field B
Conference on advances in AIDS vaccine development : program book.: [Bethesda] : Division of AIDS, National Institute of Allergy and Infectious Diseases, [1996?] iv, 251 p Unique Identifier : AIDSLINE MED/9706921
AIDS : understanding the challenge.: Nairobi : ACE Communications, 1996 xi, 180 p. : ill., ports Unique Identifier : AIDSLINE MED/9706987; Tuju R
Medical management of HIV infection. 1996 ed.: Glenview, Ill. : Physicians & Scientists Pub. Co., c1996 ix, 303 p. : ill Unique Identifier : AIDSLINE MED/9706601; Bartlett JG
Dall'altra parte : la macchina contro l'Aids : storia di una sperimentazione.: Venezia : Marsilio, c1997 123 p. : ill (Gli specchi del presente) Unique Identifier : AIDSLINE MED/9705930; Marineo G
Sexual ecology : AIDS and the destiny of gay men.: New York : Dutton, c1997 xiii, 320 p Unique Identifier : AIDSLINE MED/9707203; Rotello G
The impact of AIDS psychological and social aspects of HIV infection.: Australia : Harwood Academic Publishers, c1997 xix, 250 p. : ill Unique Identifier : AIDSLINE MED/9708033; Catalan J; Sherr L; Hedge B
AIDS : the biological basis. 2nd ed.: Dubuque, IA : Wm. C. Brown Publishers, c1997 vii, 293 p. : ill., port Unique Identifier : AIDSLINE MED/9708356; Alcamo IE
AIDS : activism and alliances.: UK : Bristol, PA : Taylor & Francis, 1997 vii, 250 p (Social aspects of AIDS) Unique Identifier : AIDSLINE MED/9706668; Aggleton P; Davies P; Hart G
HIV/AIDS and sexually transmitted diseases.: [Geneva?] : World Health Organization, c1997 20 p Unique Identifier : AIDSLINE MED/9709895
Conference on Advances in AIDS Vaccine Development, 1997 : Ninth Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS, May 4-7, 1997 : program book. of AIDS: Bethesda, Md. : Division of AIDS, National Institute of Allergy and Infectious Diseases, [1997?] iv, 236 p Unique Identifier : AIDSLINE MED/9710489
Evaluating HIV prevention interventions.: New York : Plenum Press, c1997 xv, 295 p. : ill (AIDS prevention and mental health) Unique Identifier : AIDSLINE MED/9708579; Mantell JE; DiVittis AT; Auerbach MI
Urban health care.: State Health Care Am. 1993;:34-41. Unique Identifier : AIDSLINE MED/97360461; Shoor R; Public hospitals are straining under the burden of having to care for many of the poorest and sickest people in America. The health care problems of the nation s most disadvantaged include infectious diseases such as AIDS and tuberculosis, as well as problems related to violence and lack of access to primary care. Urb
The pharmaceutical industry.: State Health Care Am. 1993;:42-9. Unique Identifier : AIDSLINE MED/97360462; Lewis L; Siegelman S; Pharmaceutical research once focused primarily on curing infectious diseases, many of which have been virtually eliminated. Today, there is growing emphasis on finding ways to prevent, treat, and cure chronic illnesses such as cardiovascular disease and cancer.
Symposium: Issues in AIDS services delivery.: J Health Hum Serv Adm. 1997 Winter;19(3):235-318. Unique Identifier : AIDSLINE MED/97386282
Issues in AIDS services delivery: a symposium. Introduction.: J Health Hum Serv Adm. 1997 Winter;19(3):235-9. Unique Identifier : AIDSLINE MED/97373469; Liou KT
A tale of two health care delivery systems.: J Health Hum Serv Adm. 1997 Winter;19(3):240-56. Unique Identifier : AIDSLINE MED/97373470; Mor V; Stein M; Carpenter C; Mayer K; Brown University, USA.
AIDS services in Florida: who's doing what, and who's paying for it?: J Health Hum Serv Adm. 1997 Winter;19(3):257-69. Unique Identifier : AIDSLINE MED/97373471; Cruise PL; Florida Atlantic University, USA.; The rapid growth of AIDS in the 1980s was paralleled by a rapid growth in AIDS Service Organizations (ASOs) throughout the United States . This article examines one state, Florida, and the 52 ASOs to determine each ASOs organizational affiliation, major types of service offered, sources
Medicaid AIDS waivers: seeking cost effective financing of AIDS care.: J Health Hum Serv Adm. 1997 Winter;19(3):270-82. Unique Identifier : AIDSLINE MED/97373472; Dunn SM; Comprehensive AIDS Program of Palm Beach County, FL, USA.; The epidemic of Acquired Immunodeficiency Syndrome (AIDS) emerged at a time of transition in American health care and health care policy. The waiver of traditional Medicaid limitations on home and community-based health care services for persons with AIDS has been utilized by several states attempting to demonstrate m
Volunteer burnout and dropout: issues in AIDS service organizations.: J Health Hum Serv Adm. 1997 Winter;19(3):283-303. Unique Identifier : AIDSLINE MED/97373473; Gabard DL; Chapman University, CA, USA.
An analysis of employees' job involvement in a community-based AIDS service organization.: J Health Hum Serv Adm. 1997 Winter;19(3):304-18. Unique Identifier : AIDSLINE MED/97373474; Liou KT; University of Central Florida, USA.; This study analyzes employees job involvement in a community-based AIDS Service Organization (ASO). The study reveals that these employees have a relatively high level of job involvement and that three job-related factors are significantly correlated to the job involvement. The three factors are: employees perceived
If the condom breaks. A morning-after treatment for exposure to HIV might protect you from AIDS. But don't count on it.: Time. 1997 Jun 23;149(25):48. Unique Identifier : AIDSLINE MED/97390028; Gorman C
Can patients drive the future of health care?: Harv Bus Rev. 1997 Jul-Aug;75(4):146-50. Unique Identifier : AIDSLINE MED/97390020; Wyke A; Economist Intelligence Unit, London.; As the traditional system of health care in the United States gives way to a regime run increasingly by the private sector, a powerful force is emerging: the patient. According to Harvard Business School professor Regina Herzlinger, health care is much like other service industries. Pr
The effects of a participative programme on Irish pupils' attitudes to HIV/AIDS.: Health Educ Res. 1997 Jun;12(2):267-73. Unique Identifier : AIDSLINE MED/97375901; Swain R; McNamara M; Department of Applied Psychology, University College, Cork, Ireland.; The study is concerned with a general humanistic approach to health (lifeskills) education and its application to the specific issue of HIV/AIDS in the Republic of Ireland . A programme of five classroom sessions, structured to encou
Sexual behaviour in a fishing community on Lake Victoria, Uganda.: Health Transit Rev. 1997 Apr;7(1):13-20. Unique Identifier : AIDSLINE MED/97375902; Pickering H; Okongo M; Bwanika K; Nnalusiba B; Whitworth J; Medical Research Council/UVRI, Entebbe, Uganda.; This study describes the sexual behaviour of men and women in a fishing village on the shores of Lake Victoria in southwest Uganda . The village is near a well known trading town-truckstop on the main trans-Africa highway with a high recorded prevalence of HIV infection. Data were o
Socio-demographic correlates, HIV/AIDS-related cofactors, and measures of same-sex sexual behaviour among northern Thai male soldiers.: Health Transit Rev. 1997 Apr;7(1):33-60. Unique Identifier : AIDSLINE MED/97375903; London AS; VanLandingham MJ; Grandjean N; Department of Sociology, Kent State University, Ohio 44242-0001, USA.; We use data from an anonymous self-administered 1991 survey of military personnel in northern Thailand to estimate overall levels of and socio-demographic differentials in same-sex sexual behaviour in this population. Additionally, we examine the relationship between sexual exper
Too poor to treat. States are balking at paying for pricey AIDS drugs.: Newsweek. 1997 Jul 28;130(4):60. Unique Identifier : AIDSLINE MED/97400001; Pedersen D; Larson E
HIV prevention in Hungary.: Health Policy. 1997 Jun;40(3):231-6. Unique Identifier : AIDSLINE MED/97400022; Danziger R; Dept of Public Health and Policy, London School of Hygiene and; Tropical Medicine, London, UK.; Hungary is a country with relatively low HIV prevalence. Since 1989, a wide range of HIV prevention projects has been developed both by government agencies and by an increasingly active voluntary sector. While energy and resources c
Leukemia and lymphoma.: Leukemia and Lymphoma, Pathogenesis and Treatment, Molecular Aspects. 18th Symposium of the International Association for Competitive Research on Leukemia and Related Diseases. Kyoto, Japan, October 29 to November 3, 1995.. Unique Identifier : AIDSLINE MED/97618842; Anonymous; No affiliation given; The XVIII Symposium of the International Association for Comparative Research on Leukemia and Related Diseases, Leukemia and Lymphoma/Pathogenesis and Treatment/Molecular Aspects, was held October 29-November 3, 1995 in Kyoto, Japan . The symposium included plenary sessions on gene r
High level IL-2 expression vectors using HIV LTR in human colon carcinoma cell line (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A217 1997. Unique Identifier : AIDSLINE MED/97619013; Vasanwala FH; Tsang TC; Liu F; Clark PR; Luznick L; Stopeck AT; Akaporiaye ET; Hersh EM; Harris DT; Department of Microbiology and Immunology, University of; Arizona,Tucson, AZ 84721; The success of IL-2 gene therapy is dependent on high expression of the gene product. Tumor cells transduced with IL-2 and intratumoral injection of IL-2 expressing plasmids result in effective antitumor activity in some tumors. We have developed two plasmid expression
Gene regulation of de novo cholesterol synthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A416 1997. Unique Identifier : AIDSLINE MED/97619102; Tian Y; Ke S; Germino JF; Meeker R; and Gallo MA; UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08855; The aryl hydrocarbon (Ah) receptor which is a ligand activated basic HLH transcription factor. The most potent ligand 2,3,7,8-TCDD, is a tumor promoter that dramatically alters lipid profiles in rodents. TCDD, at 1 ug/kg, causes a significant inhibition of cholesterol synthesis in liver and adipose tissue in rats. We
Analysis of IL-13 receptor structure identifies three different types of receptors which utilize two different types of cloned IL-13R alpha chains (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A440 1997. Unique Identifier : AIDSLINE MED/97619122; Murata T; Obiri N; Puri R; Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, MD 20892; We recently reported that IL-13 receptor (R) can be classified into at least three major types based on the patterns of IL-13 binding and interaction with IL-4. Recently, two different human IL-13R chains have been cloned from Caki-1 renal cell carcinoma RCC) and MT-2 HTLV-1 infected T cell lines (termed here alpha an
Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxo-imidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, HIV-1 reverse transcriptase, and rat polymerase beta (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A251 1997. Unique Identifier : AIDSLINE MED/97619044; Langouet S; Muller M; Guengerich FP; Department of Biochemistry and Center in Molecular Toxicology,; Vanderbilt University School of Medicine, Nashville, Tennessee 37232; 1,N2-etheno(epsilon)guanine(Gua) and 5,6,7,9-tetrahydro-7-hydroxy-9-oxo-imidazo[1,2-a]purine HO-ethanoGua) are two modified bases formed in the reaction of DNA with 2-chlorooxirane the epoxide derivative of vinyl chloride. Both adducts incorporated in oligonucleotides retarded the 3 -extension of a complementary 10-me
Kinetics of deoxyribonucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by T7 polymerase exo- and HIV-1 reverse transcriptase (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A277 1997. Unique Identifier : AIDSLINE MED/97619069; Lowe LG; Einolf HJ; Guengerich FP; Department of Biochemistry and Center in Molecular Toxicology,; Vanderbilt University School of Medicine, Nashville, TN 37232; The replicative enzymes bacteriophage T7 pol exo- (T7-) and HIV-1 reverse transcriptase (HIV-1 RT) were used with a 24/36-mer sequence to examine the kinetics of incorporation of C and A at a site-specific 8-oxo-7,8-dihydroguanine (8-oxoGua). HIV-1 RT showed a high preference for insertion of A opposite 8-oxoGua. Stea
Black-bordered warning box for cidofovir.: Aids Patient Care STDS. 1997 Apr;11(2):100. Unique Identifier : AIDSLINE MED/97290229
Drug interaction advisory.: Aids Patient Care STDS. 1997 Apr;11(2):102. Unique Identifier : AIDSLINE MED/97290231
Pharmacia and Upjohn and Gilead sciences receive European recommendation for cidofovir.: Aids Patient Care STDS. 1997 Apr;11(2):102. Unique Identifier : AIDSLINE MED/97290230
Different clarithromycin doses affect mortality.: Aids Patient Care STDS. 1997 Apr;11(2):102-3. Unique Identifier : AIDSLINE MED/97290232
Hepatitis B and adefovir depivoxil.: Aids Patient Care STDS. 1997 Apr;11(2):103. Unique Identifier : AIDSLINE MED/97290233
NDA filed to treat refractory herpes.: Aids Patient Care STDS. 1997 Apr;11(2):103. Unique Identifier : AIDSLINE MED/97290234
Repertoire of safer sex tools and behavioral options is the key to HIV/STD prevention for women.: Aids Patient Care STDS. 1997 Apr;11(2):104. Unique Identifier : AIDSLINE MED/97290236
College girls get the message via role playing and small-group workshops.: Aids Patient Care STDS. 1997 Apr;11(2):105-6. Unique Identifier : AIDSLINE MED/97373500
HIV prevention programs aimed at women are cost-effective.: Aids Patient Care STDS. 1997 Apr;11(2):106. Unique Identifier : AIDSLINE MED/97290238
AIDS aware.: Aids Patient Care STDS. 1997 Apr;11(2):110-7. Unique Identifier : AIDSLINE MED/97290239
Important new findings concerning the pathophysiology and treatment of HIV/AIDS were presented at the 4th Conference on Retroviruses and Opportunistic Infections, held in Washington, DC, January 22-26, 1997 [editorial]: Aids Patient Care STDS. 1997 Apr;11(2):58-9. Unique Identifier : AIDSLINE MED/97290215; Laurence J
Delayed diagnosis of M. tuberculosis in an HIV-infected male.: Aids Patient Care STDS. 1997 Apr;11(2):60-1. Unique Identifier : AIDSLINE MED/97290216; Newshan G; Leon W; AIDS Center Program, St. Vincent's Hospital, New York, NY, USA.
Skin and mucosal characteristics of symptomatic primary HIV-1 infection.: Aids Patient Care STDS. 1997 Apr;11(2):67-70. Unique Identifier : AIDSLINE MED/97290218; Lapins J; Gaines H; Lindback S; Lidbrink P; Emtestam L; Department of Dermatovenereology, Huddinge Hospital, Karolinska; Institute, Sweden.
Atypical presentations of progressive multifocal leukoencephalopathy (PML): aseptic meningitis and Anton's syndrome.: Aids Patient Care STDS. 1997 Apr;11(2):71-5. Unique Identifier : AIDSLINE MED/97290219; Burns BT; Katner HP; Couch DA; Smith MU; Bhutta T; Stephens J; Department of Internal Medicine, Mercer University School of Medicine,; Macon, GA, USA.
Foscarnet administered by portable infusion device in AIDS patients with CMV infection.: Aids Patient Care STDS. 1997 Apr;11(2):76-8. Unique Identifier : AIDSLINE MED/97290220; Bicart-See A; Obadia M; Gonzalez C; Averous S; Maurette M; Auvergnat JC; Department of Infectious Diseases, Hopitaux de Toulouse, France.
The use of alternative therapies for HIV infection: implications for patient care.: Aids Patient Care STDS. 1997 Apr;11(2):79-85. Unique Identifier : AIDSLINE MED/97290221; Carwein VL; Sabo CE; University of Washington, Tacoma, USA.
The lived experiences of Winnipeg women with HIV/AIDS.: Aids Patient Care STDS. 1997 Apr;11(2):86-92. Unique Identifier : AIDSLINE MED/97290222; Nicolas S; Schilder E; Centre Medico Social DeSalaberry District Health Centre, St. Pierre; Jolys, Manitoba, Canada.
HIV/AIDS case histories: diagnostic problems.: Aids Patient Care STDS. 1997 Apr;11(2):93. Unique Identifier : AIDSLINE MED/97290223; Godwin JH; Godwin TA; Cornell University Medical College, USA.
Public policy update: an AmFAR report.: Aids Patient Care STDS. 1997 Apr;11(2):94-5. Unique Identifier : AIDSLINE MED/97290224; Silver J
Final CESARE trial results show continued clinical and survival benefit.: Aids Patient Care STDS. 1997 Apr;11(2):96. Unique Identifier : AIDSLINE MED/97290225
Study suggests initiating saquinavir in early disease may increase duration of response.: Aids Patient Care STDS. 1997 Apr;11(2):97-8. Unique Identifier : AIDSLINE MED/97290227
IgE-bearing cells and epsilon-specific mRNA in lymphoid organs of two children with AIDS.: Pediatr AIDS HIV Infect. 1997 Apr;8(2):102-7. Unique Identifier : AIDSLINE MED/97323595; Auci DL; Smith-Norowitz T; Jagoo AD; Kleiner GI; Bluth MH; Chice SM; Bard E; Anderson V; Zevallos E; Durkin HG; Department of Pathology, State University of New York Health Science; Center at Brooklyn 11203, USA.; To characterize the cellular basis of IgE responses in HIV-positive (HIV+) children, we obtained central (bone marrow [BM], thymus) and peripheral (Peyer s patches [PP], mesenteric [MLN], and other lymph nodes [OLN], spleen), lymphoid organs from two children with AIDS (females, 2 and 8 years old), and from a non-HIV-
Risk and resilience in the cognitive functioning of children born to HIV-1-infected mothers: a preliminary report.: Pediatr AIDS HIV Infect. 1997 Apr;8(2):108-13. Unique Identifier : AIDSLINE MED/97323596; Coscia JM; Christensen BK; Henry RR; Department of Psychology, Vanderbilt University, Nashville, Tennessee; 37203, USA.; Although biologic and environmental risk factors show an age-dependent effect on children s cognitive development, outcome studies have yet to consider the role such factors play in the development of children born to HIV-1-infected women. This study explored the age-dependent differential impact of such risk factors
HIV-1 infection in a population-based twin sample.: Pediatr AIDS HIV Infect. 1997 Apr;8(2):114-9. Unique Identifier : AIDSLINE MED/97323597; Krasinski K; Turner BJ; Hauck WW; Fanning TR; New York University Medical Center-Bellevue Hospital Center, New York,; USA.; OBJECTIVE: To examine factors associated with perinatal HIV-1 transmission among twins. METHODS: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transm
Phosphorylated zidovudine concentrations in mononuclear cells in pediatric patients with human immunodeficiency virus infections.: Pediatr AIDS HIV Infect. 1997 Apr;8(2):120-6. Unique Identifier : AIDSLINE MED/97323598; Wintermeyer SM; Nahata MC; Brady MT; Sobol BJ; Venglarcik JS 3rd; Baker RC; Hunkler JA; McOwen NM; Children's Medical Center of Northwest Ohio, Toledo, USA.; PURPOSE: The efficacy of zidovudine (ZDV) in patients with HIV-1 infection may decrease over time due to its decreased activation. The objectives of this study were to determine ZDV concentrations in plasma, active phosphorylated zidovudine (pZDV) concentrations in mononuclear cells, and assess the markers of immune f
In vitro antibody production (IVAP) in the follow-up of pediatric human immunodeficiency virus type 1-infected patients.: Pediatr AIDS HIV Infect. 1997 Apr;8(2):127-9. Unique Identifier : AIDSLINE MED/97323599; Rusconi S; Riva A; Cocchi F; Massironi E; Tornaghi R; de Maddalena C; de Pasquale MP; Galli M; Clinica delle Malattic Infettive, Universita di Milano, Ospedale Luigi; Sacco, Italy.
HIV infection in women and children: where are we headed? [editorial]: Pediatr AIDS HIV Infect. 1997 Apr;8(2):86-8. Unique Identifier : AIDSLINE MED/97323591; Helfgott AW
HIV testing--time for a change [editorial]: Pediatr AIDS HIV Infect. 1997 Apr;8(2):89-90. Unique Identifier : AIDSLINE MED/97323592; Caplan AL
HIV-infected children with hemophilia: one- and two-year follow-up of neuropsychological functioning.: Pediatr AIDS HIV Infect. 1997 Apr;8(2):91-7. Unique Identifier : AIDSLINE MED/97323593; Hooper SR; Whitt JK; Tennison MB; Burchinal M; Gold SH; Hall CD; Department of Psychiatry, University of North Carolina, Chapel Hill,; USA.; This report describes the absence of neuropsychologic change observed over a 2-year period for 25 HIV-seropositive (HIV+) children and adolescents with hemophilia and 33 HIV-seronegative HIV-) controls. Efforts were made to match the groups on the basis of chronological age, race, and hemophilia severity. The baseline
Hepatitis B, syphilis, and human immunodeficiency virus: are different approaches to prenatal screening justified?: Pediatr AIDS HIV Infect. 1997 Apr;8(2):98-101. Unique Identifier : AIDSLINE MED/97323594; Grimes RM; Richards EP; Rathbun KC; AIDS Education and Training Center for Texas and Oklahoma, University; of Texas--Houston Health Science Center, School of Public Health; 77225-0186, USA.
Chances dim for fiscal `97 boost in AIDS drug funds. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):1, 10. Unique Identifier : AIDSLINE MED/97702672; Congressional leaders rejected a proposal to supplement Federal funding for State-run AIDS drug assistance programs (ADAP), and President Clinton refused to intervene. A proposal by Rep. Nancy Pelosi (D-CA) that included $68 million in additional ADAP funding was part of a supplemental appropriations bill aimed largel
Clinton sets goal of having an AIDS vaccine in 10 years. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):3. Unique Identifier : AIDSLINE MED/97702673; During a May 18, 1997 commencement address at Morgan State University, President Clinton announced the establishment of a new AIDS vaccine research center within the National Institutes of Health (NIH) and called for accelerated development of an AIDS vaccine. Clinton appealed to foreign governments and pharmaceutical
Washington adopts measure for testing prison inmates. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):4-5. Unique Identifier : AIDSLINE MED/97702674; Governor Gary Locke of Washington State signed legislation that attempts to balance the privacy interests of HIV-positive prison inmates with the safety needs of corrections officers. Bill 1605 limits disclosure of HIV-positive test results to healthcare administrators or infection-control coordinators in State and lo
Washington toughens sanctions against intentional exposure. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):4. Unique Identifier : AIDSLINE MED/97702675; Governor Gary Locke of Washington State signed a law that will impose stronger penalties against people who intentionally expose others to HIV. The Governor vetoed a provision authorizing court-ordered detention of those who continue to practice dangerous sexual behavior. The bill raises the penalty for the crime of i
Needle-exchange programs: a prickly debate.: AIDS Policy Law. 1997 Jun 13;12(11):6-8. Unique Identifier : AIDSLINE MED/97702677; Kim B; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Statistical Assessment Service, Washington, DC.; The proportion of new HIV cases among intravenous drug users is increasing steadily. One proposed solution is a federally funded and coordinated needle-exchange program (NEP). Recent developments in the needle-exchange debate highlight the difficulties in answering questions about NEP s effectiveness and appropriatene
N.J. governor vetoes mandatory testing of psychiatric patients. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):8. Unique Identifier : AIDSLINE MED/97702678; New Jersey Governor Christie Whitman conditionally vetoed a bill that would have mandated HIV testing of all patients in State psychiatric hospitals. The bill would have required patients upon admission to undergo testing for HIV, hepatitis B, hepatitis C, syphilis, gonorrhea, and other sexually transmitted diseases.
Judge suspends Kentucky law banning home test kits. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):9, 11. Unique Identifier : AIDSLINE MED/97702679; Franklin County (Kentucky) Court Judge William Graham signed an order temporarily barring the State from enforcing a statute that bans the marketing or sale of home HIV test kits. Home Access Health Corporation sought the injunction after it learned of the existence of a law making it a felony for anyone to sell, dist
Notification scrapped. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):12. Unique Identifier : AIDSLINE MED/97702681; The Health Department of Puerto Rico aborted plans to require individuals who test positive for HIV to report names of their sex partners to public health workers. The partner notification proposal will be converted to a voluntary program. The controversial provision would have
Stalled vaccine effort gets new boost in U.S. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 Jul;12(7):73-5. Unique Identifier : AIDSLINE MED/97702683; Development of an AIDS vaccine has slowed, partly due to the perception that new drugs, such as protease inhibitors , are so effective that vaccines will not be needed to eradicate the disease. However, since 98 percent of new cases take place in developing countries
CDC guidance expected for high-risk sexual exposure. Centers for Disease Control and Infection. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 Jul;12(7):75-7. Unique Identifier : AIDSLINE MED/97702684; The Centers for Disease Control and Prevention (CDC) is expected to issue recommendations for prophylactic treatment for health care workers exposed to HIV on the job. The post-exposure protocol will include a three-drug regimen for severe exposures, and it is likely that newer drugs, such as nelfinavir, will be inclu
New AIDS study suppresses T cells to stop viral growth. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 Jul;12(7):77-8. Unique Identifier : AIDSLINE MED/97702685; A controversial new study of the experimental drug BCX-34 is underway by Biocryst Pharmaceuticals. The drug suppresses T cells, a radically different approach; however, the drug is highly reversible. T cell counts return to pretreatment levels within two weeks after the drug is discontinued. The drug is already in Pha
Needle-exchange issue put on front burner. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 Jul;12(7):79-80. Unique Identifier : AIDSLINE MED/97702686; There are renewed pressures on the Federal government to lift the ban on needle exchange programs and to devote more funds to fighting what is the primary mode of HIV transmission in the United States . More than one-third of the 548,000 AIDS cases in the U.S. are attributed to injectio
New treatments give HIV reporting added weight. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 Jul;12(7):80-3. Unique Identifier : AIDSLINE MED/97702687; The success of early combination therapy has underscored the importance of early detection, but is spurring efforts at both the State and Federal levels to push for mandatory HIV reporting. Protease inhibitors have precipitated the debate over a public health approach
FDA explores new antiretroviral trial designs: interview with David Feigal, M.D. [interview by John S. James]: AIDS Treat News. 1997 Jun 20;(No 273):1-5. Unique Identifier : AIDSLINE MED/97702688; Feigal D; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; At its public meeting, July 14 and 15, the Food and Drug Administration s ( FDA ) Antiviral Drugs Advisory Committee will explore ways to design clinical drug trials so that they are completed faster and more safely. The FDA is considering changing the clinical endpoints requirement for
Protease inhibitors: FDA warns doctors of diabetes risk. Food and Drug Administration. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Jun 20;(No 273):5-6. Unique Identifier : AIDSLINE MED/97702689; The Food and Drug Administration ( FDA ) is warning AIDS physicians that there may be a slight risk of developing diabetes and hyperglycemia among patients receiving protease inhibitor therapy. The attack rate appears to be less than one percent and the FDA is not suggesting discontinui
1592: protests on small access program. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Jun 20;(No 273):6-8. Unique Identifier : AIDSLINE MED/97702690; Glaxo Wellcome has announced a small compassionate use program for its experimental drug, 1592 ( abacavir ). The program will make 1592 available to 2,500 adults and children in countries where the drug is a
Three States consider raising penalties for exposure to HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):1, 5. Unique Identifier : AIDSLINE MED/97702691; Lawmakers in California, New Jersey, and Alaska voted to impose stronger penalties on individuals who expose others to HIV through sex or drug needles. Each of the three States senates voted to approve stronger penalties based on high profile cases involving men who knowingly transmitted HIV to women, or threatened t
Soldier loses bid to contest Army's safer-sex order. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):2. Unique Identifier : AIDSLINE MED/97702693; The U.S. Supreme Court refused to review an appeal by an HIV-infected soldier, Carinel Pritchard, Jr., who claimed he was wrongly imprisoned for having unprotected sex with his wife. The high court said it would not consider the soldier s argument that the Army violated his marital privacy rights. Pritchard acknowledg
Court says inmate not harmed by suspension of HIV drug. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):2. Unique Identifier : AIDSLINE MED/97702694; The 6th U.S. Circuit Court of Appeals ruled that a prisoner denied access to AZT for three days did not suffer cruel and unusual punishment. Thaddeus-X, an inmate in Jackson, MI, appealed a lower court dismissal of civil rights claims. The corrections
CDC considers 'morning after' therapy for sexual exposure. Centers for Disease Control and Prevention. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):4. Unique Identifier : AIDSLINE MED/97702696; The Centers for Disease Control and Prevention (CDC) will convene a panel to consider sanctioning a morning after treatment to prevent HIV transmission from sex with an infected partner. The meeting was prompted by advocates who say people exposed to HIV should be given the same antiretroviral therapy recommended in t
Needle-exchange bill passes California senate by one vote. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):4. Unique Identifier : AIDSLINE MED/97702697; California s Senate approved legislation authorizing experimental needle-exchange programs in four cities: San Francisco, Los Angeles, San Jose, and Long Beach. Officials in these cities will decide whether their city will participate. The proposed legislation cited several studies showing that HIV transmission rates
Study shows condom use does not promote promiscuity. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):6-7. Unique Identifier : AIDSLINE MED/97702698; Researchers from Switzerland s Lausanne University Institute of Social and Preventative Medicine report the results of a media and school-based prevention education program that promoted condom use, sexual abstinence, and marital fidelity. Findings indicated that condom usage has increased dramatically and people are
49 States poised to accept Federal aid to teach abstinence. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):6. Unique Identifier : AIDSLINE MED/97702699; A Federal program offering funds to States that implement an abstinence-only curriculum for school children is being well received in every State except Wyoming. In Wyoming, a task force recommended that the governor not accept the money because it amounts to federally-dictated morality. The program gives $4 in Federa
Evidence of AIDS dementia may void defendant's guilty plea. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):7. Unique Identifier : AIDSLINE MED/97702700; A three-judge panel of the 4th U.S. Circuit Court of Appeals said that a district court failed to address Dee Deirdre Farmer s AIDS-related dementia when she entered a guilty plea on credit card fraud. Farmer is a male-to-female transsexual who did not learn she was mentally impair
Court reverses finding of discrimination in dental practice. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):9. Unique Identifier : AIDSLINE MED/97702702; A New York appeals court annulled a $25,000 damage award after concluding that there was insufficient proof to support a finding that dentists Edward Anker, Jeffrey Schulman, and Jules Shteierman discriminated against a patient because of his HIV status. The dentists appealed to the States s Supreme Court Appellate Di
Jury sees racial bias in Philadelphia's top AIDS agency. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):11. Unique Identifier : AIDSLINE MED/97702703; The former director of Philadelphia s AIDS Activities Coordinating Office was found guilty of violating the civil rights of four employees by denying them promotions or stripping them of responsibilities because of their race. A Federal jury determined that Richard Scott, who directed the office from 1993 to 1994, pas
Adherence, compliance, and HAART.: AIDS Clin Care. 1997 Jul;9(7):51-4, 58. Unique Identifier : AIDSLINE MED/97702704; Williams A; Friedland G; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Yale / New Haven Hospital, AIDS Care Program, New Haven, CT.; The development and use of new, highly active antiretroviral therapy (HAART) requires a discussion of a factor that is key to the success of these regimens, i.e., patient adherence. The term compliance is more often used, but adherence is the preferred term and considered more accurate because it implies and recognize
Treating a survivor.: AIDS Clin Care. 1997 Jul;9(7):55, 58. Unique Identifier : AIDSLINE MED/97702705; Zuger A; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; A case study is presented of a 27-year-old male, in the late stages of AIDS, who benefitted from recent advances in HIV therapy. During recovery from his fourth episode of pneumocystis pneumonia and newly-diagnosed disseminated Mycobacterium avium MAC) infection, he agreed to take antiretrovirals. He received treatmen
3TC receives full approval.: Posit Aware. 1997 May/Jun;8(3):11. Unique Identifier : AIDSLINE MED/97702706; Grodeck B; Vazquez E; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; 3TC ( Epivir /lamivudine) has received full Food and Drug Administration ( FDA ) approval following its accelerated approval in November 1995. It has sho
Volunteers wanted to study HIV treatments. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Posit Aware. 1997 May/Jun;8(3):14. Unique Identifier : AIDSLINE MED/97702707; The National Institutes of Health (NIH) is soliciting volunteers for several studies of new treatments for HIV and AIDS. Studies are planned for treatments for MAC and CMV retinitis, as well as for several new antiviral agents and vaccines. The agency will fly p
T-cell basics.: Posit Aware. 1997 May/Jun;8(3):20-1, 25. Unique Identifier : AIDSLINE MED/97702709; Munk B; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; HIV Coordinating Council of New Mexico, Albuquerque, NM.; T cell counts played a major role in monitoring HIV progression and treatment prior to the development of viral load testing. Drugs now being prescribed not only reduce viral load, but frequently cause a rebound in T cell counts. The role of T cells is described. Research is underway to address the question of whether
Arms buildup. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Posit Aware. 1997 May/Jun;8(3):26-7. Unique Identifier : AIDSLINE MED/97702710; DHEA (dehydroepiandrosterone) is the latest is a series of trendy drugs that may build body mass and increase energy, and has become popular with the general public. DHEA may also have value in HIV treatments by boosting T cell counts, lowering viral load, and preventing wasting; however, tests are inconclusive. DHEA
Is your doctor competent?: Posit Aware. 1997 May/Jun;8(3):28-31. Unique Identifier : AIDSLINE MED/97702711; Condor B; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Chicago Tribune, Chicago, IL.; HIV-positive patients are consistently healthier and live longer when their care is managed by a physician with significant experience in treating HIV and AIDS, and it is essential for patients to seek out health care providers who keep up with current treatment guidelines. Experienced doctors generally offer more agg
Party at your own risk.: Posit Aware. 1997 May/Jun;8(3):32-7. Unique Identifier : AIDSLINE MED/97702712; Cox S; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Recreational drug use in patients on antiviral therapy can have fatal consequences. Levels of the drug Ecstasy can be increased dangerously in people taking ritonavir , especially in people with some liver dysfunction. There are few studies being done
Yellow alert. What you need to know about HIV and viral hepatitis.: Posit Aware. 1997 May/Jun;8(3):40-2, 45-6. Unique Identifier : AIDSLINE MED/97702713; Beaubien G; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Most experts recommend hepatitis vaccines for people who are HIV-positive as the risk factors for both diseases are similar, but there is no firm link between viral hepatitis and the health or longevity of people with HIV. There are five forms of hepatitis, with varying health impacts, and experts estimate that as man
Limited immune recovery after treatment with antiretrovirals, IL-2; interview with Clifford Lane, M.D. [interview by John S. James]: AIDS Treat News. 1997 Jun 6;(No 272):1-5. Unique Identifier : AIDSLINE MED/97702715; Lane C; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Clifford Lane, M.D., Clinical Director of the U.S. National Institute of Allergy and Infectious Disease (NIAID), responds to questions about changes in the immune system after treatment with antiretroviral agents and interleukin-2. Dr. Lane indicates that the degree of immune restoration after treatment with these age
Nelfinavir is number 4 -- but should it bat cleanup, or lead off?: J Int Assoc Physicians AIDS Care. 1997 Jun;3(6):17-21. Unique Identifier : AIDSLINE MED/97702716; Mascolini M; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Critical issues are addressed concerning when to use nelfinavir, a newly approved protease inhibitor. Because of a resistance mutation that occurs as a result of taking nelfinavir, the following questions arise: if resistance emerges in a patient naive to protease inhibitor therapy, will that person be able to take an
Leishmaniasis in HIV-infected persons: a review.: J Int Assoc Physicians AIDS Care. 1997 Jun;3(6):22-39. Unique Identifier : AIDSLINE MED/97702717; Paredes R; Laguna F; Clotet B; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Hospital Universitari Germans Trias i Pujol, , Barcelona, Spain.; Leishmaniasis, a group of syndromes caused by a number of species of the dimorphic protozoa Leishmania, is discussed in terms of its pathogenesis, natural history, and clinical presentation as influenced by AIDS. The various types of leishmaniasis can affect many areas of the body and have numerous different clinical
How far can you knock down HIV? An interview with David D. Ho, MD. [interview by Mark Mascolini]: J Int Assoc Physicians AIDS Care. 1997 Jun;3(6):40-4. Unique Identifier : AIDSLINE MED/97702718; Ho DD; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; Dr. David Ho discusses the degree to which HIV can be eradicated in the system using antiretroviral therapy containing protease inhibitors . Dr. Ho reports that among 20 patients remaining on his study using either
Predicting antiviral compliance: physicians' responsibilities vs. patients' rights.: J Int Assoc Physicians AIDS Care. 1997 Jun;3(6):45-8. Unique Identifier : AIDSLINE MED/97702719; Senak M; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; AIDS Project Los Angeles, Los Angeles, CA.; Predicting which patients will comply with anti-HIV drug regimens is a very serious issue, since lack of compliance may cause development of drug-resistant strains of HIV that can be passed on to others. Ethical issues include addressing the well-being of the patient versus public health. Physicians are put in the pos
AIDS patients sought for study with NTZ for cryptosporidiosis. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: J Int Assoc Physicians AIDS Care. 1997 Jun;3(6):48. Unique Identifier : AIDSLINE MED/97702720; Patients are being recruited for a phase II/III trial using nitazoxanide for cryptosporidiosis. This is a six-week, double-blind, placebo-controlled trial to determine the efficacy and safety of nitazoxanide in HIV-positive patients with cryptosporidiosis. More information can be obtained by calling AIDS Clinical Tria
AIDS medical glossary. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: GMHC Treat Issues. 1997 Jun;11(6):1-36. Unique Identifier : AIDSLINE MED/97702736; A glossary of AIDS medical terms is presented. The glossary includes a list of alternate names for commonly prescribed medications. Definitions of drugs, treatments, opportunistic diseases, and types of cells are provided.
[Protease inhibitors]: Sidahora. 1996 Dec - 1997 Jan;:39-44. Unique Identifier : AIDSLINE MED/97702750; Markowitz M; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; New York University, Medical Center, New York, NY.; Basic questions about protease inhibitors , drugs that are used to slow the spread of the HIV virus, are answered. Definitions of HIV infection and AIDS, HIV protease, and protease inhibitors are given. How protease inhibitors work, which inhibitors are in current st
STDs, HIV, and crack cocaine: a review.: Aids Patient Care STDS. 1997 Apr;11(2):62-6. Unique Identifier : AIDSLINE MED/97290217; Wilson T; DeHovitz JA; Department of Preventive Medicine and Community Health, State; University of New York, Health Science Center, Brooklyn, USA.
FDA Advisory Committee stalemates on delavirdine.: Aids Patient Care STDS. 1997 Apr;11(2):96-7. Unique Identifier : AIDSLINE MED/97290226
Human chorionic gonadotropin's benefit in KS may only be cosmetic.: Aids Patient Care STDS. 1997 Apr;11(2):100. Unique Identifier : AIDSLINE MED/97290228
Empowering women marginalized by prostitution and drug abuse requires a different approach.: Aids Patient Care STDS. 1997 Apr;11(2):104-5. Unique Identifier : AIDSLINE MED/97290237
Court broadens its ruling in Maine HIV dental case. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):1-2. Unique Identifier : AIDSLINE MED/97702671; The 1st U.S. Circuit Court of Appeals in Maine reviewed a crucial paragraph in its 33-page opinion in Abbott v. Bragdon, the case of a dental patient denied care because of her HIV infection. According to the plaintiff, Ms. Sidney Abbott, the revision made a narrow ruling much broader. In the original ruling, the cour
Judge: don't wait for ADA review to file rehab act claim. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):5. Unique Identifier : AIDSLINE MED/97702676; John Cebuhar sued the Illinois Department of Alcoholism and Substance Abuse (DASA) after he was denied reasonable accommodation for his HIV condition and then was terminated. Cebuhar said DASA and three top officials violated the two disability rights statutes as well as his constitutional right to equal protection un
High court won't review AIDS medical cap on ex-employee. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 13;12(11):11. Unique Identifier : AIDSLINE MED/97702680; The U.S. Supreme Court refused to review an appeals court ruling holding that former employees cannot use the Americans with Disabilities Act (ADA) to challenge AIDS-related discrimination in post-employment fringe benefits. The high court s decision relates to the estate of Timothy Bourgeois, fired from his job at a
AIDS cap on medical insurance violates the ADA, judge rules. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):1, 10. Unique Identifier : AIDSLINE MED/97702692; A Federal judge in Atlanta found that World Insurance Company failed to give a rational explanation for its decision to cap lifetime AIDS benefits at $5,000 when most other medical conditions had a $2 million cap. In so doing, the company has violated Title III of the Americans with Disabilities Act (ADA). Policyholde
Doctor who lost her job due to HIV allowed to continue suit. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):3. Unique Identifier : AIDSLINE MED/97702695; U.S. District Judge Wayne R. Anderson rejected as premature a defense motion to dismiss an Americans with Disabilities Act ADA) claim filed by a physician who states she was denied employment at the Family Health Care Associates Clinic after she was diagnosed as HIV-positive. The judge said that depositions will have
How much does it cost to settle a discrimination claim? Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Jun 27;12(12):8-9. Unique Identifier : AIDSLINE MED/97702701; Summaries of recent out-of-court settlements in HIV discrimination lawsuits are provided. HIV discrimination suits are costly and the awards do not usually take into consideration the employer s other costs, such as attorney s fees and lost production time. The out-of-court settlements also involve non-monetary conseq
Delavirdine gets the green light.: Posit Aware. 1997 May/Jun;8(3):18-9. Unique Identifier : AIDSLINE MED/97702708; Vazquez E; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; The Food and Drug Administration ( FDA ) approved delavirdine Rescriptor ) under its accelerated approval guidelines. The non-nucleoside reverse transcr
Double dose. Twin epidemics of addiction and HIV create special medical needs.: Posit Aware. 1997 May/Jun;8(3):48-51, 55-6. Unique Identifier : AIDSLINE MED/97702714; Vazquez E; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; HIV-positive people who abuse drugs compromise their health through the life-threatening behavior. Treatment is difficult or hard to get for people who have no job or insurance, and health care is complicated when addicts engage in high-risk activities that can cause further health problems. Denial and distrust are co
[Living with HIV in recovery] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Dec - 1997 Jan;:7-11. Unique Identifier : AIDSLINE MED/97702748; Addictions are not limited to only drugs and alcohol. People can also develop addictions to food, work, money, religion, and sex. The issue of addiction and HIV is addressed in detail. Several aspects of addiction are described, including various types of addictions, their associated behaviors, and definitions of addi
[Drugs, AIDS, and recovery. "Something else will be revealed"]: Sidahora. 1996 Dec - 1997 Jan;:14-5. Unique Identifier : AIDSLINE MED/97702749; Clavell MA; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.; AIDS and drug use are serious and lethal problems. Substance abuse among people living with HIV/AIDS is increasing. An addict relates his personal experiences and anecdotes to advise others who are addicted to drugs and are living with HIV/AIDS.
Intestinal co-infection by Cyclospora sp. and Cryptosporidium parvum: first report in an AIDS patient.: Parasite. 1994 Dec;1(4):387-90. Unique Identifier : AIDSLINE MED/97285247; Scaglia M; Gatti S; Bassi P; Viale PL; Novati S; Ranieri S; Laboratory of Clinical Parasitology, University-IRCCS S. Matteo,; Pavia, Italy.; Cyclospora is recently described new human pathogenic coccidian causing intermittent diarrhoeal enteritis which may persist for weeks or months in immunocompetent subjects, particularly travellers visiting some tropical areas and countries, such as
The isolation of Leishmania donovani MON-18, from an AIDS patient in Portugal: possible needle transmission.: Parasite. 1994 Dec;1(4):391-2. Unique Identifier : AIDSLINE MED/97285248; Campino L; Santos-Gomes G; Pratlong F; Dedet JP; Abranches P; Instituto de Higiene e Medicina Tropical (IHMT), Lisboa, Portugal.; The spread of HIV infection into leishmaniasis endemic areas has increased the incidence of immunosupressed patients with kalaazar in Portugal . The dermotropic zymodeme MON-24 of leishmania infantum has been already isolated from a
Idiopathic CD4+ T-lymphocytopenia and recurrent vulvar intraepithelial neoplasia.: Obstet Gynecol. 1994 Oct;84(4 Pt 2):712-4. Unique Identifier : AIDSLINE MED/97349539; Park K; Monk BJ; Wilczynski S; Ito JI Jr; Vasilev SA; Department of Gynecologic Oncology, City of Hope National Medical; Center, Durate, California, USA.; BACKGROUND: CD4+ T-lymphocytopenia immunodeficiency without human immunodeficiency virus (HIV) infection has been reported recently. The association between immunodeficiency and anogenital neoplasia secondary to human papillomavirus infections is well documented. CASE: A woman with recurrent vulvar intraepithelial neo
Pathogenicity of Cyclospora sp [letter]: Parasite. 1994 Mar;1(1):94. Unique Identifier : AIDSLINE MED/97285209; Garavelli PL
Kinetics of HIV-1 RNA concentration changes in pediatric patients.: Pathobiology. 1996;64(6):289-94. Unique Identifier : AIDSLINE MED/97302775; Zeichner SL; Mueller BU; Pizzo PA; Dimitrov DS; HIV and AIDS Malignancies Branch, National Cancer Institute, NIH,; Bethesda, MD 20892, USA. Zeichner@nih.gov; Recent studies have used potent antiviral agents to investigate the kinetics of HIV infection in vivo. They provided estimates for important kinetic parameters, including the decay constants for circulating virus and infected CD4+cells. However, since all of these studies fundamentally rely on the use of antiviral age
Neuronal damage and its relation to dementia in acquired immunodeficiency syndrome (AIDS).: Pathobiology. 1996;64(6):295-307. Unique Identifier : AIDSLINE MED/97302776; Trillo-Pazos G; Everall IP; Department of Neuropathology, Institute of Psychiatry, London, UK.; There are an estimated 21.8 million people infected with human immunodeficiency virus (HIV) worldwide [Weekly Epidemiol Rec 1996; 27:204-208] and 90% of these people will have some form of neuropathological abnormality during the course of acquired immunodeficiency syndrome (AIDS). In this review, we will highlight th
Human T cell leukemia virus type I (HTLV-I) and human diseases.: Annu Rev Immunol. 1997;15:15-37. Unique Identifier : AIDSLINE MED/97288729; Uchiyama T; Institute for Virus Research, Kyoto University, Japan.; tuchiyam@virus1.virus.kyoto-u.ac.jp; HTLV-I infection is causally associated with a variety of human diseases including leukemia/lymphoma, myelopathy, uveitis, and arthropathy. Tax protein of HTLV-I, which is considered oncogenic, binds to transcription factors or other cytoplasmic cellular molecules involved in the fundamental cell function and thereby
Escape of human immunodeficiency virus from immune control.: Annu Rev Immunol. 1997;15:271-96. Unique Identifier : AIDSLINE MED/97288738; McMichael AJ; Phillips RE; Nuffield Department of Medicine, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford, United Kingdom.; andrew.mcmichael%mailgate.jr2@ox.ac.uk; Cytotoxic T lymphocytes (CTL) play a crucial role in the attempt to control infection with human immunodeficiency virus (HIV). Variation in epitopes recognized by CTL is common and frequently offers potential escape routes for mutant virus. Proof of escape, however, requires demonstration of increased frequency of vir
Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.: Annu Rev Immunol. 1997;15:297-322. Unique Identifier : AIDSLINE MED/97288739; Constant SL; Bottomly K; Section of Immunobiology, Yale University School of Medicine, New; Haven, Connecticut, USA.; T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses.
Redox regulation of cellular activation.: Annu Rev Immunol. 1997;15:351-69. Unique Identifier : AIDSLINE MED/97288741; Nakamura H; Nakamura K; Yodoi J; Institute for Virus Research, Kyoto University, Japan.; Growing evidence has indicated that cellular reduction/oxidation redox) status regulates various aspects of cellular function. Oxidative stress can elicit positive responses such as cellular proliferation or activation, as well as negative responses such as growth inhibition or cell death. Cellular redox status is mai
Bone marrow-derived dendritic cells, infection with human immunodeficiency virus, and immunopathology.: Annu Rev Immunol. 1997;15:593-615. Unique Identifier : AIDSLINE MED/97288750; Knight SC; Patterson S; Antigen Presentation Research Group, Imperial College School of; Medicine at Northwick Park Institute for Medical Research, Harrow,; Middlesex, United Kingdom.; Dendritic cells (DC) exposed to HIV-1 show nonproductive infection that may become productive as they mature. The distribution of DC within genital mucosa and their susceptibility to infection particularly with clade E viruses could be reflected in the ease of heterosexual transmission. Carriage of virus and viral ant
Role of complement in HIV infection.: Annu Rev Immunol. 1997;15:649-74. Unique Identifier : AIDSLINE MED/97288752; Stoiber H; Clivio A; Dierich MP; Institut fur Hygiene, Innsbruck, Austria. Stoiber.hygiene@uibk.ac.at; In human plasma, HIV activates the complement system, even in the absence of specific antibodies. Complement activation would, however, be harmful to the virus if the reactions were allowed to go to completion, since their final outcome would be virolysis. This is avoided by complement regulatory molecules, which eith
Human chemokines: an update.: Annu Rev Immunol. 1997;15:675-705. Unique Identifier : AIDSLINE MED/97288753; Baggiolini M; Dewald B; Moser B; Theodor Kocher Institute, University of Bern, Switzerland.; baggiolini@tki.unibe.ch; Interleukin 8, the first chemokine to be characterized, was discovered nearly ten years ago. Today, more than 30 human chemokines are known. They are often upregulated in inflammation and act mainly on leukocytes inducing migration and release responses. The present review deals largely with the new developments of th
Computer-assisted, quantitative cytokine enzyme-linked immunospot analysis of human immune effector cell function.: Biotechniques. 1997 Jun;22(6):1146-9. Unique Identifier : AIDSLINE MED/97331434; Cui Y; Chang LJ; University of Alberta, Edmonton, Canada.; Originally developed for detecting antibody production from B lymphocytes, the enzyme-linked immunospot (ELISPOT) assay was later modified to assess cytokine production from various immune effector cells. Although the ELISPOT assay can detect antibody or cytokine production at the single-cell level, the visual countin
Human immunodeficiency virus and the complement system.: Exp Clin Immunogenet. 1997;14(1):11-5. Unique Identifier : AIDSLINE MED/97331585; Gras G; Legendre C; Richard Y; Dormont D; Service de Neurovirologie, CEA et CRSSA, Fontenay-aux-Roses, France.; gras@dsvidf.cea.fr
Reactive oxygen species and nitric oxide in viral diseases.: Biol Trace Elem Res. 1997 Jan;56(1):107-16. Unique Identifier : AIDSLINE MED/97297045; Peterhans E; Institute of Veterinary Virology, University of Berne, Switzerland.; peterhans@ivv.unibe.ch; Metabolites derived from superoxide (O2.-) and nitric oxide (NO.) play an important role in antimicrobial and antitumoral defense, but may also harm the host. Low levels of such metabolites can also facilitate viral replication because of their mitogenic effects on cells. Most viruses grow better in proliferating cell
Possibilities of a viral etiology for human breast cancer. A review.: Biol Trace Elem Res. 1997 Jan;56(1):131-42. Unique Identifier : AIDSLINE MED/97297048; Pogo BG; Holland JF; Department of Medicine, Mount Sinai School of Medicine, CUNY, New; York, NY 10029, USA.; Previous studies related mouse mammary tumor virus (MMTV) to human breast cancer. However, the presence of human endogenous retroviruses (HERs) confounded these results. We selected a 660-bp sequence of the MMTV env gene with low homology to HER (or any other known gene) and searched for a sequence homologous to it, u
Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection.: Biol Trace Elem Res. 1997 Jan;56(1):31-41. Unique Identifier : AIDSLINE MED/97297041; Look MP; Rockstroh JK; Rao GS; Kreuzer KA; Spengler U; Sauerbruch T; Department of General Internal Medicine, University of Bonn, Germany.; Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7 +/- 12.2 micrograms/L; p
The distribution of selenium and mortality owing to acquired immune deficiency syndrome in the continental United States.: Biol Trace Elem Res. 1997 Jan;56(1):43-61. Unique Identifier : AIDSLINE MED/97297042; Cowgill UM; University of Colorado at Boulder, Department of EPO Biology,; Carbondale 81623, USA.; A hypothesis has been proposed that Selenium (Se) concentration in the environment as measured by its uptake by alfalfa, which sorbs Se from the soil in proportion to what is present, exerted an apparent effect on incidence of (acquired immune deficiency syndrome) AIDS such that AIDS mortality within the conterminous
Genomic structures of viral agents in relation to the biosynthesis of selenoproteins.: Biol Trace Elem Res. 1997 Jan;56(1):63-91. Unique Identifier : AIDSLINE MED/97297043; Taylor EW; Nadimpalli RG; Ramanathan CS; Computational Center for Molecular Structure and Design, University of; Georgia, Athens 30601-2352, USA. wtaylor@rx.uga.edu; The genomes of both bacteria and eukaryotic organisms are known to encode selenoproteins, using the UGA codon for seleno-cysteine SeC), and a complex cotranslational mechanism for SeC incorporation into polypeptide chains, involving RNA stem-loop structures. These common features and similar codon usage strongly sugge
Academic pediatrics in the Emma Children's Hospital, Academic Medical Center in Amsterdam (The Netherlands).: Pediatr Hematol Oncol. 1997 May-Jun;14(3):199-203. Unique Identifier : AIDSLINE MED/97328689; Stuve W; Weening RS; Emma Children's Hospital, Academic Medical Center, Amsterdam, The; Netherlands.; In 1988 the Emma Children s Hospital and the department of pediatrics of the Academic Medical Center in Amsterdam (The Netherlands ) merged. With the integration of the Emma Children s Hospital and the academic pediatric department, an academic children s hospital (ECH/ AMC) wa
Wells' syndrome: a pathogenic role for circulating CD4+CD7- T cells expressing interleukin-5 mRNA.: Br J Dermatol. 1997 Jun;136(6):918-23. Unique Identifier : AIDSLINE MED/97360863; Yagi H; Tokura Y; Matsushita K; Hanaoka K; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of Medicine,; Japan.; Wells syndrome, or eosinophilic cellulitis, is a rare dermatosis characterized histologically by a dermal infiltrate of eosinophils, lymphocytes and histiocytes between collagen bundles and amorphous or granular eosinophilic deposits on collagen, constituting flame figures. We report a 54-year-old woman with eosinoph
Active psoriasis and profound CD4+ lymphocytopenia.: Br J Dermatol. 1997 Jun;136(6):930-2. Unique Identifier : AIDSLINE MED/97360865; Hardman CM; Baker BS; Lortan J; Breuer J; Surentheran T; Powles A; Fry L; Department of Dermatology, St Mary's Hospital, London, U.K.; We report the case of a patient with a long-standing history of widespread chronic plaque psoriasis, who was recently found to have a profound CD4+ lymphocytopenia. He is human immunodeficiency virus (HIV) negative. His psoriasis remains active and widespread, and he has had 60 cutaneous malignancies, including many s
Unusual skin ulceration in an HIV-positive patient who had cutaneous syphilis and neurosyphilis.: Br J Dermatol. 1997 Jun;136(6):946-8. Unique Identifier : AIDSLINE MED/97360870; Tucker SC; Yates VM; Thambar IV; Department of Dermatology, Burnley General Hospital, Burnley,; Lancashire, UK.; We present a case of a patient coinfected with syphilis and the human immunodeficiency virus (HIV) who had unusual and severe cutaneous ulceration. The profound immune defects associated with HIV may lead to an altered clinical presentation and a more aggressive course in patients infected with Treponema pallidum. Des
One and a half decades of the Lugano International Conference on Malignant Lymphoma: variations on a theme or true progress?: Ann Oncol. 1997;8 Suppl 1:1-3. Unique Identifier : AIDSLINE MED/97331088; Ultmann JE; Ong ST; Stupp R; Department of Medicine, University of Chicago, IL, USA.
[Compliance, efficacy and tolerability of the therapeutic regimen recommended by National Consensus on Tuberculosis]: Enferm Infecc Microbiol Clin. 1997 Mar;15(3):129-33. Unique Identifier : AIDSLINE MED/97269476; Colmenero JD; Garcia-Ordonez MA; Sebastian MD; Perez-Ruiz E; Sanchez-Lora J; Sanchez-Gonzalez J; Bentabol G; Juarez C; Unidad de Enfermedades Infecciosas, Hospital Regional Carlos Haya de; Malaga.; BACKGROUND: To study the degree of adhesion, efficacy, and tolerance of therapeutic guidelines advocated by the National Consensus on tuberculosis. METHODS: A prospective study of a cohort of 84 patients receiving a diagnosis of tuberculosis in a Basic General Health Area between 1-3-1993 and 28-2-1994 treated with th
[Fever and cavitated pulmonary infiltrates in a patient with AIDS]: Enferm Infecc Microbiol Clin. 1997 Mar;15(3):165-6. Unique Identifier : AIDSLINE MED/97269484; Gainzarain JC; Sanchez MJ; Gijon P; Padilla B; Berenguer J; Servicio de Microbiologia Clinica y Enfermedades Infecciosas, Hospital; General Universitario Gregorio Maranon, Madrid.
[Bacteremia caused by Corynebacterium urealyticum in 2 patients co-infected with HIV and HBV (letter)]: Enferm Infecc Microbiol Clin. 1997 Mar;15(3):172-3. Unique Identifier : AIDSLINE MED/97269491; Aracil B; Perea B; Barros C; Gomez-Garces JL
[Zalcitabine]: Enferm Infecc Microbiol Clin. 1997 Mar;15(3):177-8. Unique Identifier : AIDSLINE MED/97269494
Progressive multifocal leukoencephalopathy in HIV [editorial]: Int J STD AIDS. 1997 Jun;8(6):351-7. Unique Identifier : AIDSLINE MED/97323154; Sadler M; Nelson MR; Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by infection of oligodendrocytes by JC virus. As patients with HIV survive longer with severe immunodeficiency, the incidence of PML is rising. Diagnosis is not always easy and the gold standard remains his
The ocular complications of HIV and AIDS.: Int J STD AIDS. 1997 Jun;8(6):358-65; quiz 365-7. Unique Identifier : AIDSLINE MED/97323155; Greenwood J; Graham EM; Harrison Wing and Medical Eye Unit, St Thomas' Hospital, London, UK.
Comparison of patients refusing with patients accepting unlinked anonymous HIV testing in an outpatient STD department in The Netherlands.: Int J STD AIDS. 1997 Jun;8(6):368-72. Unique Identifier : AIDSLINE MED/97323156; Postema EJ; Willems PW; de Ridder MA; van der Meijden WI; Department of Dermato-Venereology, University Hospital Rotterdam, The; Netherlands.; From 1 February 1993 to 1 February 1994 all new patients, known patients with new problems, and prostitutes attending the Outpatient Department of Sexually Transmitted Diseases (STD) of the University Hospital Rotterdam were asked to participate in unlinked anonymous human immunodeficiency virus (HIV) testing and to a
STD/AIDS knowledge and risk behaviour among masseuses and bar hostesses in Singapore.: Int J STD AIDS. 1997 Jun;8(6):373-7. Unique Identifier : AIDSLINE MED/97323157; Chan R; Goh CL; National Skin Centre Singapore, Singapore.; Sex workers are not confined to brothels, they also include a variety of individuals who practise part-time in establishments conductive to sexual liaisons. We undertook to study the extent of sex work among masseuses and nightclub hostesses and the level of AIDS and STD knowledge in these 2 groups. The studies were c
Difference of virus populations in HIV carriers in relation to AZT treatment.: Int J STD AIDS. 1997 Jun;8(6):378-81. Unique Identifier : AIDSLINE MED/97323158; Sakamoto T; Wakamiya N; Tochikura A; Tsuchie H; Kurimura T; Department of Viral Infections, Osaka University, Japan.; To analyse the appearance of AZT-resistant HIV in HIV carriers after AZT treatment and compare the mutations responsible for resistance employing cloned HIV DNA derived from provirus and free virions in plasma, serial blood specimens were taken before and after AZT treatment. RNA in virions in plasma, proviral DNA and
The epidemiology of notified genital Chlamydia trachomatis infection in Victoria, Australia: a survey of diagnosing providers.: Int J STD AIDS. 1997 Jun;8(6):382-7. Unique Identifier : AIDSLINE MED/97323159; Thompson SC; McEachern KA; Stevenson EM; Forsyth JR; Epidemiology and Social Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; Data on 259 notified cases of genital chlamydia infection diagnosed in Victoria Australia in January and February 1995 were augmented by call-back. Risk factor data was available for 221. Patients were primarily adolescents or young adults (median age 23 years); 66% were women.
Lack of behavioural risk factors for squamous intraepithelial lesions (SIL) in HIV-infected women.: Int J STD AIDS. 1997 Jun;8(6):388-92. Unique Identifier : AIDSLINE MED/97323160; Heard I; Jeannel D; Bergeron C; Saada M; Henrion R; Kazatchkine MD; Service d'Immunologie, INSERM U 430, Hopital Broussais, Paris, France.; HIV-infected women have a high prevalence of abnormal Papanicolaou smears and cervical intraepithelial neoplasia. A multiparametric analysis of epidemiological and behavioural risk factors has been performed in a cohort of 204 HIV-infected women in an outpatient clinic with the aim to investigate risk factors associat
Severe primary HIV-1 infection among black persons in Barbados.: Int J STD AIDS. 1997 Jun;8(6):393-7. Unique Identifier : AIDSLINE MED/97323161; Hudson CP; Levett PN; Edwards CN; Moosai R; Roach TC; Department of Medicine, University of the West Indies, Queen Elizabeth; Hospital, Barbados.; Descriptions of primary HIV-1 infection have so far been based on Caucasians living in industrialized nations. Due to studies of leptospirosis in the predominantly black population of Barbados , serum was available for patients admitted with acute febrile illnesses to the Queen El
Rise in sexually transmitted diseases during democratization and economic crisis in Mongolia.: Int J STD AIDS. 1997 Jun;8(6):398-401. Unique Identifier : AIDSLINE MED/97323162; Purevdawa E; Moon TD; Baigalmaa C; Davaajav K; Smith ML; Vermund SH; National Center for Hygiene, Epidemiology and Microbiology, Ministry; of Health, Ulaanbaatar, Mongolia.; In 1990, democratic changes and loss of Soviet economic subsidies led to enormous social upheaval in Mongolia . The objective of this study is to map sexually transmitted disease (STD) trends in Mongolia from 1983-1995 and review human immunodeficiency virus HIV) surveillance data
Hypercalcaemia in a patient with AIDS and Mycobacterium avium intracellulare infection.: Int J STD AIDS. 1997 Jun;8(6):405. Unique Identifier : AIDSLINE MED/97323164; Newell A; Nelson MR; Kobler Clinic, St Stephens' Centre, Chelsea and Westminster Hospital,; London.
Liposomal amphotericin B and recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) in the treatment of paediatric AIDS-related cryptococcosis.: Int J STD AIDS. 1997 Jun;8(6):406-8. Unique Identifier : AIDSLINE MED/97323165; Manfredi R; Coronado OV; Mastroianni A; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita di Bologna, Italy.
An audit of the management of pelvic inflammatory disease.: Int J STD AIDS. 1997 Jun;8(6):409-11. Unique Identifier : AIDSLINE MED/97323166; Wales NM; Barton SE; Boag FC; Booth SJ; Smith JR; Department of Genitourinary Medicine, Chelsea and Westminster; Hospital, London, UK.
Genital warts, trichomoniasis and other concurrent STIs in Scotland [letter]: Int J STD AIDS. 1997 Jun;8(6):412. Unique Identifier : AIDSLINE MED/97323167; Thompson C
Impact of tuberculosis control measures and crowding on the incidence of tuberculous infection in Maryland prisons.: Clin Infect Dis. 1997 Jun;24(6):1060-7. Unique Identifier : AIDSLINE MED/97338498; MacIntyre CR; Kendig N; Kummer L; Birago S; Graham NM; National Centre for Epidemiology and Population Health, Australian; National University, Canberra, Australia.; Our aim was to determine the incidence of tuberculin skin test TST) conversion in the Maryland state correctional system. We conducted a historical longitudinal cohort study. A sample of 1,289 inmates, incarcerated in 16 of 23 prisons, who had a negative TST and a second test within 24 months was selected. The inciden
Photo quiz. Choroidal lesions of disseminated cryptococcosis.: Clin Infect Dis. 1997 Jun;24(6):1079, 1239. Unique Identifier : AIDSLINE MED/97338500; Rajagopalan S; Fong DS; Boyapalli R; Department of Internal Medicine, King/Drew Medical Center, Charles R.; Drew University of Medicine and Science, Los Angeles, California, USA.
Case-control study of risk factors for Penicillium marneffei infection in human immunodeficiency virus-infected patients in northern Thailand.: Clin Infect Dis. 1997 Jun;24(6):1080-6. Unique Identifier : AIDSLINE MED/97338501; Chariyalertsak S; Sirisanthana T; Supparatpinyo K; Praparattanapan J; Nelson KE; Department of Community Medicine, Faculty of Medicine, Chiang Mai; University, Thailand.; A case-control study was done in Chiang Mai, Thailand , comparing risk-related behavior and exposures in 80 incident cases of disseminated Penicillium marneffei infection in patients with AIDS and 160 control patients with AIDS who did not have P. marneffei infection. All subjects
Use of polymerase chain reaction assays of aqueous humor in the differential diagnosis of retinitis in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Jun;24(6):1100-6. Unique Identifier : AIDSLINE MED/97338504; Danise A; Cinque P; Vergani S; Candino M; Racca S; De Bona A; Novati R; Castagna A; Lazzarin A; Department of Infectious Diseases, San Raffaele Scientific Institute,; Milan, Italy.; We performed polymerase chain reaction (PCR) for detection of cytomegalovirus ( CMV ), varicella-zoster virus (VZV), herpes simplex virus (HSV), and Toxoplasma gondii DNA in aqueous humor from 15 patients who were infected with
Prevalence of Campylobacter-associated diarrhea among patients infected with human immunodeficiency virus [see comments]: Clin Infect Dis. 1997 Jun;24(6):1107-13. Unique Identifier : AIDSLINE MED/97338505; Snijders F; Kuijper EJ; de Wever B; van der Hoek L; Danner SA; Dankert J; Department of Medical Microbiology, University of Amsterdam, The; Netherlands.; We performed a cross-sectional study at an outpatient AIDS clinic to assess the prevalence of Campylobacter species in stool specimens from 201 consecutive patients infected with human immunodeficiency virus (HIV). We characterized campylobacters phenotypically and genetically by using primers for the group of common
Diversity of Campylobacter species and its impact on patients infected with human immunodeficiency virus [editorial; comment]: Clin Infect Dis. 1997 Jun;24(6):1114-7. Unique Identifier : AIDSLINE MED/97338506; Quinn TC
Disseminated bacille Calmette-Guerin disease after vaccination: case report and review.: Clin Infect Dis. 1997 Jun;24(6):1139-46. Unique Identifier : AIDSLINE MED/97338512; Talbot EA; Perkins MD; Fagundes S; Silva M; Frothingham R; Department of Medicine, Duke University Medical Center, Durham, North; Carolina, USA.; The attenuated bacille Calmette-Guerin (BCG) vaccine is administered to prevent tuberculosis. Complications of vaccination are uncommon. We report a new case of disseminated BCG disease and review 27 additional cases identified from a review of > 5,000 reports published between 1980 and 1996. Twenty-four of the 28 tot
Prospective study of histoplasmosis in patients infected with human immunodeficiency virus: incidence, risk factors, and pathophysiology.: Clin Infect Dis. 1997 Jun;24(6):1195-203. Unique Identifier : AIDSLINE MED/97338522; McKinsey DS; Spiegel RA; Hutwagner L; Stanford J; Driks MR; Brewer J; Gupta MR; Smith DL; O'Connor MC; Dall L; Infectious Disease Associates of Kansas City, University of; Missouri-Kansas City School of Medicine, St. Luke's Hospital, USA.; Histoplasmosis is a common opportunistic infection in patients with human immunodeficiency virus (HIV) infection who reside in areas where Histoplasma capsulatum is endemic. We undertook a prospective study of a cohort of 304 HIV-Infected patients in Kansas City from October 1990 through March 1993 to define the incid
Oropharyngeal candidiasis in patients with AIDS: randomized comparison of fluconazole versus nystatin oral suspensions.: Clin Infect Dis. 1997 Jun;24(6):1204-7. Unique Identifier : AIDSLINE MED/97338523; Pons V; Greenspan D; Lozada-Nur F; McPhail L; Gallant JE; Tunkel A; Johnson CC; McCarty J; Panzer H; Levenstein M; Barranco A; Green S; Division of Infectious Disease, University of California Hospital, San; Francisco 94143, USA.; A total of 167 human immunodeficiency virus (HIV)-infected patients with oropharyngeal candidiasis were randomly assigned to receive 14 days of therapy with liquid suspension fluconazole 100 mg once daily) or liquid nystatin (500,000 U four times daily). At day 14, 87% of the fluconazole-treated patients were clinical
Adverse reactions to thalidomide in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Jun;24(6):1223-7. Unique Identifier : AIDSLINE MED/97338527; Haslett P; Tramontana J; Burroughs M; Hempstead M; Kaplan G; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, New York 10021-6399, USA.; Thalidomide is emerging as a useful agent in the management of several complications of disease due to human immunodeficiency virus (HIV). We conducted three prospective studies of 56 HIV-infected patients who were treated with thalidomide for 14-21 days; 24 (43%) of these patients discontinued therapy owing to advers
Mycobacterium kansasii disease in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Jun;24(6):1233-8. Unique Identifier : AIDSLINE MED/97338529; Campo RE; Campo CE; Adult AIDS Program, University of Miami School of Medicine, Florida; 33101-6960, USA.; We evaluated the presenting characteristics, response to therapy, and outcome for 46 patients infected with Mycobacterium kansasii and human immunodeficiency virus (HIV). M. kansasii infection occurred late in HIV disease (mean CD4 lymphocyte count, 52.4/mm3), when most patients had already developed AIDS; 91.3% of th
Systemic infection with Mycobacterium genavense following immunosuppressive therapy in a patient who was seronegative for human immunodeficiency virus.: Clin Infect Dis. 1997 Jun;24(6):1245-7. Unique Identifier : AIDSLINE MED/97338532; Bogdan C; Kern P; Richter E; Tannapfel A; Rusch-Gerdes S; Kirchner T; Solbach W; Department for Internal Medicine III, University of Erlangen, Germany.; We describe, to our knowledge, the first case of disseminated Mycobacterium genavense infection in a patient who was seronegative for human immunodeficiency virus. The patient, a 47-year-old woman, had been previously treated with immunosuppressive drugs for 9 months to control an unclassified immunologic disorder cha
Clinical significance of splenic tuberculosis in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Jun;24(6):1248-51. Unique Identifier : AIDSLINE MED/97338533; Gonzalez-Lopez A; Dronda F; Alonso-Sanz M; Chaves F; Fernandez-Martin I; Lopez-Cubero L; Unidad de Enfermedades Infecciosas-Microbiologia Clinica, Hospital; General Penitenciario, Madrid, Spain.; To assess the clinical significance of splenic tuberculosis in patients infected with human immunodeficiency virus (HIV) type 1, we compared 20 patients who had splenic tuberculosis with 20 randomly selected, HIV-infected patients with culture-proven tuberculosis for whom splenic involvement had been ruled out by ultr
Clinical profile of herpes zoster ophthalmicus in Ethiopians.: Clin Infect Dis. 1997 Jun;24(6):1256-60. Unique Identifier : AIDSLINE MED/97338535; Bayu S; Alemayehu W; Department of Ophthalmology, Faculty of Medicine, Addis Ababa; University, Ethiopia, East Africa.; We conducted a prospective study of 100 consecutive Ethiopian patients with herpes zoster ophthalmicus (HZO); this study revealed a high incidence of HZO among the young (mean age, 35 years). Eighty-one (95%) of 85 patients who underwent serological testing were seropositive for antibodies to human immunodeficiency vi
Rifampin-resistant Mycobacterium kansasii infection in a patient with AIDS who was receiving rifabutin.: Clin Infect Dis. 1997 Jun;24(6):1262-3. Unique Identifier : AIDSLINE MED/97338537; Meynard JL; Lalande V; Meyohas MC; Petit JC; Frottier J; Service des Maladies Infectieuses et Tropicales, Hopital; Saint-Antoine, Paris, France.
Pneumocystis carinii Pneumonia in Asians and Pacific Islanders.: Clin Infect Dis. 1997 Jun;24(6):1265-7. Unique Identifier : AIDSLINE MED/97338540; Eckholdt H; Chin J; Division of Tuberculosis Elimination, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.
Cutaneous Mycobacterium avium complex infection at an intramuscular injection site in a patient with AIDS.: Clin Infect Dis. 1997 Jun;24(6):1273-4. Unique Identifier : AIDSLINE MED/97338546; Meadows JR; Carter R; Katner HP; Department of Internal Medicine, Mercer University School of Medicine,; Macon, Georgia 31201, USA.
Severe recalcitrant erythematous desquamating disorder associated with fatal recurrent toxic shock syndrome in a patient without AIDS.: Clin Infect Dis. 1997 Jun;24(6):1274-5. Unique Identifier : AIDSLINE MED/97338547; Verbon A; Fisher CJ Jr; Department of Internal Medicine, Academic Medical Center, Amsterdam,; The Netherlands.
Structure-activity relationships in quinoline Reissert derivatives with HIV-1 reverse transcriptase inhibitory activity.: Drug Des Discov. 1997 Apr;14(4):259-72. Unique Identifier : AIDSLINE MED/97341686; Font M; Monge A; Ruiz I; Heras B; Dpt. of Medicinal Chemistry, Centro de Investigacion en; Farmacobiologia Aplicada, Universidad de Navarra, Pamplona, Espana.; The relationship between the chemical structure and the HIV-1 RT inhibitory activity has been studied for a series of quinoline derivatives. Two methods were used: a standard QSAR analysis, by combining the methods of Hansch and Free-Wilson, and an analysis using quantum chemistry indices as descriptor parameters, by
Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives.: Drug Des Discov. 1997 Apr;14(4):291-303. Unique Identifier : AIDSLINE MED/97341688; Monge A; Alvarez E; San Martin C; Nadal E; Ruiz I; Font M; Martinez-Irujo JJ; Santiago E; Prieto I; Lasarte JJ; Sarobe P; Borras F; Medicinal Chemistry, Universidad de Navarra, Pamplona, Spain.; The synthesis and preliminary evaluation of new benzo[f]quinoline and pyridine derivatives, obtained by application of the Reissert method and its modifications, as HIV-1 RT inhibitors and anti-infectives are presented. The most active products against HIV-1 RT wild type are the ethyl 2-cyano-1,2-dihydrobenzo[f]quinol
Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives.: Drug Des Discov. 1997 Apr;14(4):305-32. Unique Identifier : AIDSLINE MED/97341689; Font M; Monge A; Alvarez E; Cuartero A; Losa MJ; Fidalgo MJ; SanMartin C; Nadal E; Ruiz I; Merino I; Martinez-Irujo JJ; Alberdi E; Santiago E; Prieto I; Lasarte JJ; Sarobe P; Borras F; Medicinal Chemistry, Universidad de Navarra, Pamplona, Spain.; The synthesis and preliminary evaluation of new quinoline and quinoxaline derivatives (obtained by applying the original Reissert method, conveniently modified) as HIV-1 Reverse Transcriptase (RT) inhibitors are presented in this paper; likewise, the first structure-activity relationships are also proposed. Propyl 2-c
Review article: the therapy of gastrointestinal infections associated with the acquired immunodeficiency syndrome.: Aliment Pharmacol Ther. 1997 Jun;11(3):425-43. Unique Identifier : AIDSLINE MED/97361172; Wilcox CM; Monkemuller KE; Department of Medicine, University of Alabama of Birmingham; 35294-0007.; Although there have been dramatic strides in the therapy of human immunodeficiency virus infection over the last few years, the number of infected people world-wide is tremendous and, at least in developing countries, continues to expand. Complications which involve the gastrointestinal tract are common in these patie
[Radiographic findings in Pneumocystis carinii pneumonia and its complications in HIV patients]: An Med Interna. 1997 Mar;14(3):114-8. Unique Identifier : AIDSLINE MED/97275479; Marin Rodriguez C; Gallego Herrero C; Sanchez-Nistal MA; Rasero Ponferrada M; Servicio de Radiodiagnostico, Hospital Universitario 12 de Octubre,; Madrid.; We have performed a retrospective study of 61 cases of Pneumocystis carinii pneumonia (PCP) among the Human Immunodeficiency Virus (HIV) seropositive population at the 11th Health Area of the Comunidad de Madrid with microbiological diagnosis until January 1994. We made an Epidemiologic analysis of this PCP group and
[Association of lung adenocarcinoma and human immunodeficiency virus infection]: An Med Interna. 1997 May;14(5):250-2. Unique Identifier : AIDSLINE MED/97347552; De Miguel Diez J; Gaspar Alonso-Vega G; Pontes Valero J; Mateo Rodriguez O; Gomez Santos D; Serrano Iglesias JA; Servicio de Neumologia, Hospital Universitario de Getafe, Madrid.; In the past decade, few studies have reported the occurrence of lung cancer in HIV-infected patients. The true frequency of this association is known. The major features of these patients include: male gender, young age, a history of intravenous drug abuse, preponderance of adenocarcinoma cell type and advanced clinic
[Tuberculosis and HIV infection: epidemiology (the first of three parts)]: An Med Interna. 1997 May;14(5):253-6. Unique Identifier : AIDSLINE MED/97347553; Martinez Vazquez JM; Cabarcos Ortiz de Barron A; Barrio Gomez E; Servicio de Medicina Interna, Complejo Hospitalario Universitario de; Santiago, Santiago de Compostela, La Coruna.
[Cryptococcal meningitis in an intravenous drug abuse HIV negative person (letter)]: An Med Interna. 1997 May;14(5):264-5. Unique Identifier : AIDSLINE MED/97347557; Nerin Sanchez C; Hermida Lazcano I; Martinez Alvarez R; Arazo Garces P; Figueras Villalba P; Aguirre Errasti JM
A stochastic model for the analysis of bivariate longitudinal AIDS data.: Biometrics. 1997 Jun;53(2):542-55. Unique Identifier : AIDSLINE MED/97335784; Sy JP; Taylor JM; Cumberland WG; Department of Biostatistics, University of California, Los Angeles; 90095, USA.; We present a model for multivariate repeated measures that incorporates random effects, correlated stochastic processes, and measurement errors. The model is a multivariate generalization of the model for univariate longitudinal data given by Taylor, Cumberland, and Sy (1994, Journal of the American Statistical Associ
Assessing interrater agreement from dependent data.: Biometrics. 1997 Jun;53(2):707-14. Unique Identifier : AIDSLINE MED/97335793; Williamson JM; Manatunga AK; Division of HIV/AIDS (E-48), Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Estimation of interrater agreement for ordered categorical data is examined when the same sample is being assessed by various raters with different methods. We investigate the use of a latent model proposed by Qu, Piedmonte, and Medendorp (1995, Biomerics 51, 268-275) to estimate the correlation between raters for eac
Weighted logrank tests to detect a transient improvement in survivorship.: Biometrics. 1997 Jun;53(2):736-44. Unique Identifier : AIDSLINE MED/97335795; Wallenstein S; Berger A; Department of Biomathematical Sciences, Mount Sinai School of; Medicine, New York, New York 10029, USA.; In investigating whether an intervention has an effect on survival, we exploit the flexibility of weighted logrank tests for constructing optimal tests sensitive to specified patterns of changes in the ratios or differences of the hazards as a function of time. The tests presented seem appropriate if either the interv
Regional decreases [corrected] in AMPA receptor density in mice infected with the LP-BM5 murine leukemia virus [published erratum appears in Neuroreport 1997 Jul 5;8(9-10):2410]: Neuroreport. 1997 Mar 24;8(5):1243-7. Unique Identifier : AIDSLINE MED/97318139; Kustova Y; Espey MG; Sei Y; Basile AS; Laboratory of Neuroscience, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892-0008, USA.; The status of alpha-amino-3-hydroxy-5-methyl-4-isoxizole (AMPA) receptors in several brain regions was investigated in a murine model of retrovirus-associated cognitive impairment, the LP-BM5 infected mouse. The Bmax of [3H]AMPA receptors in the cortex, striatum, hippocampus and cerebellum declined by 29-50% as early
Activation of cytotoxic and natural killer T-cell system in patients with hepatocellular carcinoma and cirrhosis.: Ital J Gastroenterol. 1996 Dec;28(9):493-8. Unique Identifier : AIDSLINE MED/97278059; Marafin C; Rinaldi M; Angonese C; De Franchis G; Plebani M; Naccarato R; Farinati F; Cattedra Malattie Apparato Digerente, Universita di Padova, Italy.; The immune response in liver cirrhosis and hepatocellular carcinoma is receiving renewed attention in consideration of the possible treatment with biological response modifiers. The aim of this study was to evaluate whether cirrhosis and hepatocellular carcinoma induce any modification in peripheral lymphocyte subsets
Intraepidermal IgA pustulosis associated with monoclonal IgA gammopathy in an HIV-infected patient [letter]: Dermatology. 1997;194(3):308-9. Unique Identifier : AIDSLINE MED/97331528; Barnadas MA; Nadal C; Verger G; Gelpi C; Rodriguez JL; de Moragas JM
Modeling the impact of HIV on the spread of tuberculosis in the United States.: Math Biosci. 1997 Jul 1;143(1):35-60. Unique Identifier : AIDSLINE MED/97342242; West RW; Thompson JR; Department of Statistics, University of South Carolina, Columbia; 29208, USA.; Tuberculosis (TB) was thought to be safely in decline in the United States in the mid-1980s because the number of cases had dropped by 74% between 1953 and 1985. An increase in TB cases was reported, however, in 1986, and an upward trend in TB incidence has continued. The turnaround in
[The antibiotic resistance of Staphylococcus aureus strains isolated in units with an elevated nosocomial risk and in outpatient facilities in 1995]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jan-Jun;42(1-2):51-4. Unique Identifier : AIDSLINE MED/97344442; Grigore L; Dumitrescu V; Sfartz S; Codita I; Institutul Cantacuzino, Bucuresti.; Antibiotic susceptibility testing in 231 strains of S. aureus isolated from patients highly exposed to the nosocomial risk and from patients treated in ambulatories for staphylococcal infections revealed significant discrepancies in respect to the incidence of multiple resistant strains and dispersion of resistance ph
[The specific serological profile in hepatitis B virus infection in children]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jan-Jun;42(1-2):55-7. Unique Identifier : AIDSLINE MED/97344443; Iancu LS; Moraru E; Gotia S; Apetrei C; Azoicai D; Ivan A; Duca M; U.M.F. Gr. T. Popa, Iasi, Disciplina de Microbiologie.; Hepatitis B virus infection (HBV) has a very well known specific serologic profile. In the last years the molecular biology methods reveal some particular serological profiles by genomic mutation. One particular profile consists in the absence of anti-HBc total antibodies simultaneously with the presence of HBsAg. O
[Hepatitis B virus reactivation in patients infected with HIV]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jan-Jun;42(1-2):59-63. Unique Identifier : AIDSLINE MED/97344444; Ciutica I; Bastides F; Besnier M; Barin F; Choutet P; Clinica de Boli Infectioase, UMF Cluj Napoca, Romania.; The authors study the reactivation of B hepatitis virus in three HIV infected patients, correlating the moment of reactivation of and the CD4 and CD8 lymphocytes. Prior to the B viral reactivation, the three patients were with Ac HBc IgG (+) in serum, assessing that the presence of AC HBc IgG is insufficient to preven
[The epidemiological considerations of the evolution of HIV/AIDS in Iasi County in 1990-1995]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jan-Jun;42(1-2):77-80. Unique Identifier : AIDSLINE MED/97344447; Ivan A; Mitroi I; Azoicai D; Grigorescu R; Dragomir C; Duceag L; U.M.F. Gr. T. Popa, Iasi.
[The impact of an AIDS hotline service on pupils and students]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jan-Jun;42(1-2):81-3. Unique Identifier : AIDSLINE MED/97344448; Duma OO; Universitatea de Medicina si Farmacie Iasi.
[Opinions on the rights of seropositive persons or AIDS patients and the conduct adopted towards them]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jan-Jun;42(1-2):85-6. Unique Identifier : AIDSLINE MED/97344449; Tuchendria E; Duma O; C.M.S.S.C. Iasi.
Russia fears rapid increase in HIV infection [news]: BMJ. 1997 Jun 21;314(7097):1783. Unique Identifier : AIDSLINE MED/97367371; Ingram M
HIV associated tuberculosis [editorial]: BMJ. 1997 Jun 28;314(7098):1847. Unique Identifier : AIDSLINE MED/97367412; Coker R; Miller R
AIDS turnaround: first remedy the adverse effects of the condom policy [letter]: Eur J Cancer Prev. 1997 Feb;6(1):96-9. Unique Identifier : AIDSLINE MED/97305561; Gjorgov AN
Trace elements and vitamins in immunomodulation in infancy and childhood.: Eur J Cancer Prev. 1997 Mar;6 Suppl 1:S69-77. Unique Identifier : AIDSLINE MED/97309726; Zuin G; Principi N; Clinica Pediatrica IV, Universita di Milano, Italy.; It has been established that there is a strict and cyclical relationship between infection, immune function and nutritional status with changes in one influencing the other two. Impairment of immune function can occur even in healthy subjects in apparently good nutritional status as a consequence of some nutrient defi
Antiviral substance from silkworm faeces: purification and its chemical characterization.: Biol Pharm Bull. 1997 May;20(5):547-55. Unique Identifier : AIDSLINE MED/97322283; Hiraki A; Yukawa M; Kim J; Ueda S; Institute of Molecular and Cellular Biology for Pharmaceutical; Sciences, Kyoto Pharmaceutical University, Yamashina-ku, Japan.; In a previous paper, we reported that an extract of silkworm faeces has a marked antiviral activity on enveloped viruses, but not on a non-enveloped virus, and we showed that it inhibits the synthesis of a viral specific gene of HVJ (Sendai virus) without affecting the viral adsorption and entry into the host cell. In
Protein delivery from biodegradable microspheres.: Pharm Biotechnol. 1997;10:1-43. Unique Identifier : AIDSLINE MED/97304082; Cleland JL; Genentech, Inc., South San Francisco, California 94080, USA.; The key components to the successful development of a biodegradable microsphere formulation for the delivery of proteins are polymer chemistry, engineering, and protein stability. These areas are intricately related and require a thorough investigation prior to embarking on the encapsulation of proteins. While each of
A case of central cord syndrome caused by intubation: a case report.: J Spinal Cord Med. 1997 Apr;20(2):230-2. Unique Identifier : AIDSLINE MED/97289829; Yan K; Diggan MF; Department of Rehabilitation Medicine and Restorative Sciences,; University of Illinois at Chicago 60612, USA.; Following intubation for respiratory distress, a 42 year-old female patient sustained a hyperextension injury which produced a central cord syndrome. This paper illustrates an unusual mechanism whereby a central cord syndrome was caused by pure hyperextension without high velocity force.
[Consequences of carriage for caregivers and for the patient of a possible presumption of viral (HIV) contamination of a patient by a caregiver]: Bull Acad Natl Med. 1997 Feb;181(2):361-7. Unique Identifier : AIDSLINE MED/97342134; Henrion R
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.: Immunity. 1997 Jun;6(6):673-9. Unique Identifier : AIDSLINE MED/97352445; Taki S; Sato T; Ogasawara K; Fukuda T; Sato M; Hida S; Suzuki G; Mitsuyama M; Shin EH; Kojima S; Taniguchi T; Asano Y; Department of Immunology, Faculty of Medicine, University of Tokyo,; Japan.; Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiatio
Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo.: Immunity. 1997 Jun;6(6):681-9. Unique Identifier : AIDSLINE MED/97352446; Lohoff M; Ferrick D; Mittrucker HW; Duncan GS; Bischof S; Rollinghoff M; Mak TW; Ontario Cancer Institute, and the Department of Immunology, University; of Toronto, Canada.; The transcription factor interferon regulatory factor-1 (IRF-1) mediates the effects of IFN. No information exists on its role in lymphokine production. Protection against the intracellular pathogen Leishmania major depends on a Th1 response. Here, we show that CD4+ T cells from Leishmania-infected mice lacking one or
[An experimental study on injury of intestinal immuno-barrier in rat after scald]: Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 1996 Mar;12(2):86-9. Unique Identifier : AIDSLINE MED/97350376; Yu Y; Sheng ZY; Tian H; Trauma Center, 304th Hospital of People's Liberation Army, Beijing.; A dynamic observation on injury of intestinal immuno-barrier in scalded rat was performed to investigate the relationship between the injury of intestinal immuno-barrier and bacterial translocation. After 40% TBSA third degree scald, a decrease of IgA in intestinal content and the number of CD3+ and CD4+ T lymphocyte,
Indinavir-induced nephropathy.: Tenn Med. 1997 Jul;90(7):286-8. Unique Identifier : AIDSLINE MED/97359311; Weber L; Campbell H; Gritter NJ; Vanderbilt University Medical Center, Nashville, USA.
Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2',3'-dideoxycytidine-induced lymphomas.: Cancer Res. 1997 Jul 1;57(13):2710-4. Unique Identifier : AIDSLINE MED/97349077; Zhuang SM; Cochran C; Goodrow T; Wiseman RW; Soderkvist P; Department of Cell Biology, Faculty of Health Sciences, University; Hospital, Linkoping University, Sweden.; Mutations of p53 and ras genes were analyzed in 40 and 31 1,3-butadiene (BD)-induced lymphomas of B6C3F1 mice (BLFs), respectively, and in 63 2 ,3 -dideoxycytidine-induced lymphomas, which were collected from B6C3F1 (n = 16) or NIH Swiss mice DLSs; n = 47). The frequencies of K- and N-ras mutations in BLFs 32 and 13%,
Respiratory illness in HIV-negative immunocompromised patients.: Curr Opin Pulm Med. 1997 Mar;3(2):125-30. Unique Identifier : AIDSLINE MED/97337116; Tietjen PA; White DA; Saint Vincent's Hospital and Medical Center, New York, NY 10011, USA.; Pulmonary complications in immunosuppressed patients continue to be a source of morbidity and mortality. Prophylaxis, early recognition, and aggressive treatment remain the keys to management.
Nontuberculous mycobacteria.: Curr Opin Pulm Med. 1997 Mar;3(2):139-45. Unique Identifier : AIDSLINE MED/97337118; Griffith DE; University of Texas Health Center, Tyler, Center for Pulmonary; Infectious Disease Control 75710, USA.; The nontuberculous mycobacteria (NTM), especially Mycobacterium avium complex, are being recognized with increasing frequency as clinical pathogens, not only as a cause of disseminated disease in patients with AIDS but also as a cause of chronic lung disease in patients without AIDS. These infections have traditionall
Pulmonary complications of HIV infection.: Curr Opin Pulm Med. 1997 Mar;3(2):151-8. Unique Identifier : AIDSLINE MED/97337120; Schneider RF; Rosen MJ; Beth Israel Medical Center, Division of Pulmonary and Critical Care; Medicine, New York, NY 10003, USA.; With changes in epidemiology and the application of newer treatment and prophylactic regimens, the types of pulmonary diseases that occur in HIV-infected persons are changing. New ways to assess the progression of HIV disease and new antiretroviral treatments are available. Increased survival is often coupled with wor
Incidence, etiologic pathogens, and diagnostic testing of community-acquired pneumonia.: Curr Opin Pulm Med. 1997 Mar;3(2):89-97. Unique Identifier : AIDSLINE MED/97337110; File TM Jr; Tan JS; Department of Medicine, Northeastern Ohio Universities College of; Medicine, Akron 44304, USA.; Determination of the etiologic pathogens of community-acquired pneumonia has been problematic because of the lack of reliable rapid laboratory diagnostic tools as well as the controversy concerning diagnostic criteria. In the studies reviewed here, a specific pathogen was identified in 39% to 88% of patients. Streptoc
Neuropathogenesis of HIV-1 infection: interactions between interleukin-1 and transforming growth factor-beta 1.: Mol Psychiatry. 1997 Mar;2(2):111-2. Unique Identifier : AIDSLINE MED/97260134; Vitkovic L; Division of Neuroscience and Behavioral Science, National Institute of; Mental Health, National Institutes of Health, Rockville, MD 20857,; USA. vitkovic@helix.nih.gov; Cytokines are widely considered to function as major mediators of neuropathogenesis of HIV-1 infection. This view is based on a large amount of data obtained in vitro, in animal models and in human brain tissue obtained postmortem. Evidence for the involvement of interleukin-1 and transforming growth factor-beta 1, su
Use of Norplant implants in asymptomatic HIV-1 infected women.: Contraception. 1997 Apr;55(4):205-7. Unique Identifier : AIDSLINE MED/97322961; Taneepanichskul S; Intaraprasert S; Phuapradit W; Chaturachinda K; Department of Obstetrics and Gynaecology, Faculty of Medicine,; Ramathibodi Hospital, Manidol University, Bangkok, Thailand.; The study of Norplant implants use in HIV-1 infected women was conducted at the Family Planning Clinic, Department of Obstetrics and Gynaecology. Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand , from January 1993 to June 1996. The purpose of the st
Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection.: Drugs. 1997 Jun;53(6):1054-80. Unique Identifier : AIDSLINE MED/97323041; Adkins JC; Peters DH; Faulds D; Adis International Limited, Auckland, New Zealand. demail@adis.co.nz; Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2 ,3 -dideoxycytidine 5 -triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminati
Mouse lymphoma workshop: Victoria, British Columbia, Canada, March 27, 1996 protocol issues regarding the use of the Microwell Method of the Mouse Lymphoma Assay.: Environ Mol Mutagen. 1997;29(4):434-8. Unique Identifier : AIDSLINE MED/97356360; Sofuni T; Wilcox P; Shimada H; Clements J; Honma M; Clive D; Green M; Thybaud V; San RH; Elliott BM; Muller L; National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.; sofuni@nihs.go.jp
Long-term transgene expression in fetal rat suprachiasmatic nucleus neurografts following ex vivo adenoviral vector-mediated gene transfer.: Exp Neurol. 1997 Jun;145(2 Pt 1):536-45. Unique Identifier : AIDSLINE MED/97360061; Boer GJ; van Esseveldt KE; Hermens WT; Liu R; Verhaagen J; Graduate School Neurosciences Amsterdam, Netherlands Institute for; Brain Research, Amsterdam.; Ex vivo gene transfer to fetal suprachiasmatic nucleus SCN)-containing solid piece neurografts was explored using a first-generation prototype adenoviral vector containing the reporter gene LacZ (Ad-LacZ). Transgene expression was examined at different intervals following grafting in the IIIrd ventricle of rat brain a
Lung and blood T-cell receptor repertoire in extrinsic allergic alveolitis [see comments]: Eur Respir J. 1997 Apr;10(4):772-9. Unique Identifier : AIDSLINE MED/97294556; Wahlstrom J; Berlin M; Lundgren R; Olerup O; Wigzell H; Eklund A; Grunewald J; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Patients with extrinsic allergic alveolitis (EAA) have accumulations of T-lymphocytes in their lungs. CD8+ lung T-cells, in particular, have been implicated in the pathogenesis of EAA. The objective of the present study was to analyse the T-cell receptor (TCR) V alpha and V beta gene usage of CD4+ and CD8+ lung and pe
Pleural tuberculosis.: Eur Respir J. 1997 Apr;10(4):942-7. Unique Identifier : AIDSLINE MED/97294582; Ferrer J; Servei de Pneumologia, Hospital General Universitari Vall d'Hebron,; Barcelona, Spain.; Tuberculous pleural effusions occur in up to 30% of patients with tuberculosis. It appears that the percentage of patients with pleural effusion is comparable in human immunodeficiency virus HIV)-positive and HIV-negative individuals, although there is some evidence that HIV-positive patients with CD4+ counts
Pneumothorax in HIV-infected patients: role of Pneumocystis carinii pneumonia and pulmonary tuberculosis.: Eur Respir J. 1997 Jun;10(6):1332-5. Unique Identifier : AIDSLINE MED/97336143; Tumbarello M; Tacconelli E; Pirronti T; Cauda R; Ortona L; Dept of Infectious Diseases, Catholic University, Rome, Italy.; Patients with acquired immune deficiency syndrome (AIDS) are at increased risk for pneumothorax, which usually occurs in the setting of Pneumocystis carinii pneumonia. The rationale of the present study was based on the hypothesis that the increased incidence of pulmonary tuberculosis in human immunodeficiency virus (
ACOG educational bulletin. Human immunodeficiency virus infections in pregnancy. American College of Obstetricians and Gynecologists.: Int J Gynaecol Obstet. 1997 Apr;57(1):73-80. Unique Identifier : AIDSLINE MED/97318738
Report of the FIGO Committee for the Study of Ethical Aspects of Human Reproduction. International Federation of Gynecology and Obstetrics.: Int J Gynaecol Obstet. 1997 Apr;57(1):95-9. Unique Identifier : AIDSLINE MED/97318743; Schenker JG; Hadassah Hospital, Jerusalem.
A clinical-parasitological monotherapy cure in the treatment of experimental infection by a highly virulent strain of Toxoplasma gondii.: Folia Microbiol (Praha). 1996;41(6):513-6. Unique Identifier : AIDSLINE MED/97278534; de Diego JA; Penin P; Arribas JR; Vazquez E; Vazquez JJ; Department of Preventive Medicine and Public Health, Autonomous; University, School of Medicine, Madrid, Spain.; Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome (AIDS) is treated classically with pyrimethamine plus sulfadiazine. Unfortunately, up to 40% of these patients are unable to complete the course of therapy because of adverse reactions to sulfonamides. This study considers the possible us
[Lamivudine resistance impedes hepatitis B therapy (news)]: Fortschr Med. 1997 Apr 30;115(12):5. Unique Identifier : AIDSLINE MED/97321906; Eggers HJ
Human parvovirus B19 in bone marrows from adults with acquired immunodeficiency syndrome: a comparative study using in situ hybridization and immunohistochemistry.: Hum Pathol. 1997 Jul;28(7):760-6. Unique Identifier : AIDSLINE MED/97367974; Liu W; Ittmann M; Liu J; Schoentag R; Tierno P; Greco MA; Sidhu G; Nierodzik M; Wieczorek R; New York Veterans Affairs Medical Center and New York University; Medical Center, NY 10010, USA.; Human parvovirus B19, which infects and lyses erythroid precursors, can cause severe anemia in patients with immunodeficiency. The incidence of parvovirus infection in adult acquired immunodeficiency syndrome (AIDS) patients is unknown. Eighty-one archival formalin-fixed, paraffin-embedded (FFPE) bone marrow biopsies
Inhalatory pentamidine therapy and the duration of the QT interval in HIV-infected patients.: Int J Cardiol. 1997 May 23;59(3):285-9. Unique Identifier : AIDSLINE MED/97326033; Cardoso JS; Mota-Miranda A; Conde C; Moura B; Rocha-Goncalves F; Lecour H; Cardiology Service, Porto Medical School, Hospital de S. Joao,; Portugal.; We evaluated the effect of chronic Pneumocystis carinii pneumonia PCP) prophylaxis, with a once a month dose of 300 mg of inhalatory pentamidine isethionate, on QT interval duration. We included 22 human immunodeficiency virus (HIV)-infected patients: 11 were on this medication and 11 were not. The two groups were mat
Rapid assay of intrinsic radiosensitivity based on apoptosis in human CD4 and CD8 T-lymphocytes.: Int J Radiat Oncol Biol Phys. 1997 May 1;38(2):429-40. Unique Identifier : AIDSLINE MED/97369891; Ozsahin M; Ozsahin H; Shi Y; Larsson B; Wurgler FE; Crompton NE; Institute for Medical Radiobiology of the University of Zurich and the; Paul Scherrer Institute, Villigen-PSI, Switzerland.; PURPOSE: An assay for radiosensitivity has numerous applications in the clinic. Avoidance of acute responses, prediction of normal tissue toxicity, and individualization of patient radiotherapy are included among these. We have developed a rapid assay (about 24 h) able to predict intrinsic radiosensitivity of CD4 and
Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity.: J Biol Chem. 1997 Jul 4;272(27):16807-14. Unique Identifier : AIDSLINE MED/97347480; Tozser J; Bagossi P; Weber IT; Louis JM; Copeland TD; Oroszlan S; Department of Biochemistry, University Medical School of Debrecen,; H-4012 Debrecen, Hungary. tozser@indi.biochem.dote.hu; Two major types of cleavage sites with different sequence preferences have been proposed for the human immunodeficiency virus type 1 (HIV-1) proteinase. To understand the nature of these sequence preferences better, single and multiple amino acid substitutions were introduced into a type 1 cleavage site peptide, thus
Construction of a cell-based high-flux assay for the rev protein of HIV-1.: J Virol Methods. 1997 May;65(2):153-8. Unique Identifier : AIDSLINE MED/97330479; Tang RY; Su Y; College of Life Science, National Yang-Ming University, Taipei,; Taiwan, R.O.C.; The Rev of HIV-1 is essential for the replication of the viruses and is therefore a very attractive target for the development of antiviral drugs. To establish a cell-based high-flux assay system for random screening of Rev inhibitors, cells carrying both the Rev-expressing gene and a Rev-inducible SeAP gene were gene
Molecular characterization of avian reoviruses using nested PCR and nucleotide sequence analysis.: J Virol Methods. 1997 May;65(2):159-67. Unique Identifier : AIDSLINE MED/97330480; Liu HJ; Giambrone JJ; Nielsen BL; Department of Poultry Science, Auburn University, AL 36849-5416, USA.; A nested polymerase chain reaction (PCR) with subsequent nucleotide sequence analysis identified and differentiated avian reoviruses (ARVs). PCR products amplified from the S1 gene segment of ARV of USA isolates were 738 and 342 bp, respectively. PCR products were conformed by Southern and dot blot hybridizations. The
CD4 deletion mutants evaluated for human immunodeficiency virus type 1 infectivity in a highly efficient system of expression and detection based on LTR-dependent reporter gene activation.: J Virol Methods. 1997 May;65(2):209-17. Unique Identifier : AIDSLINE MED/97330485; Moir S; Boissinot M; Tremblay M; Poulin L; Centre de Recherche du CHUL, Quebec, Canada.; The human CD4 glycoprotein is thought to be involved at several stages of the infection process with the human immunodeficiency virus type 1. To pursue this line of investigation with CD4 deletion mutants, we combined a system of high transient cell-surface expression of the target molecule with an assay of HIV-1 infe
Counselling HIV patients pursuing infertility investigation and treatment [comment] [see comments]: Hum Reprod. 1997 Mar;12(3):415-6. Unique Identifier : AIDSLINE MED/97277037; Rizk B; Dill SR; Division of Reproductive Endocrinology, University of South Alabama,; Mobile 36688, USA.
The gynaecologists' opinions [see comments]: Hum Reprod. 1997 Mar;12(3):416. Unique Identifier : AIDSLINE MED/97277038; Parazzini F; Instituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy.
Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.: J Clin Invest. 1997 Jul 1;100(1):136-41. Unique Identifier : AIDSLINE MED/97347426; Schnyder B; Mauri-Hellweg D; Zanni M; Bettens F; Pichler WJ; Institute of Immunology and Allergology, Inselspital, CH-3010-Bern,; Switzerland.; T cells can recognize small molecular compounds like drugs. It is thought that covalent binding to MHC bound peptides is required for such a hapten stimulation. Sulfamethoxazole, like most drugs, is not chemically reactive per se, but is thought to gain the ability to covalently bind to proteins after intracellular dr
Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen.: J Clin Invest. 1997 Jul 1;100(1):226-33. Unique Identifier : AIDSLINE MED/97347436; Schwarze J; Hamelmann E; Bradley KL; Takeda K; Gelfand EW; Division of Basic Sciences, Department of Pediatrics, National Jewish; Medical and Research Center, Denver, Colorado 80206, USA.; Viral respiratory infections can predispose to the development of asthma by mechanisms that are presently undetermined. Using a murine model of respiratory syncytial virus (RSV) infection, acute infection is associated with airway hyperresponsiveness as well as enhanced responses to subsequent sensitization to allerge
Transgenic dissection of HIV genes involved in lymphoid depletion.: J Clin Invest. 1997 Jul 1;100(1):32-9. Unique Identifier : AIDSLINE MED/97347415; Tinkle BT; Ueda H; Ngo L; Luciw PA; Shaw K; Rosen CA; Jay G; Department of Virology, Jerome H. Holland Laboratory, Rockville,; Maryland 20855, USA.; Transgenic mice carrying an HIV provirus, with selective deletion of all three structural genes, developed extensive lymphoid depletion which was detected not only in the spleen and lymph nodes but also in the thymus. Mice with a high level of HIV gene expression developed acute disease which resulted in premature dea
Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression.: J Clin Invest. 1997 Jul 1;100(1):84-92. Unique Identifier : AIDSLINE MED/97347421; Bruggeman LA; Dikman S; Meng C; Quaggin SE; Coffman TM; Klotman PE; Divison of Nephrology, Mount Sinai Medical Center, New York 10029,; USA. lbrugge@smtplink.mssm.edu; HIV-associated nephropathy (HIVAN) is a progressive glomerular and tubular disease that is increasingly common in AIDS patients and one of the leading causes of end stage renal disease in African Americans. A major unresolved issue in the pathogenesis of HIVAN is whether the kidney disease is due to renal cell infecti
Macronodular hepatic granulomas due to visceral leishmaniasis in an AIDS patient: imaging findings.: J Comput Assist Tomogr. 1997 Jul-Aug;21(4):677-9. Unique Identifier : AIDSLINE MED/97359868; Canalias J; Falco J; Martin J; Jurado I; SDI-UDIAT, Consorci Hospitalari del Parc Tauli, Sabadell, Barcelona,; Spain.
Depletion of circulating allergen-specific TH2 T lymphocytes after allergen exposure in asthma.: J Allergy Clin Immunol. 1997 Jun;99(6 Pt 1):788-97. Unique Identifier : AIDSLINE MED/97358127; Crimi E; Gaffi D; Frittoli E; Borgonovo B; Burastero SE; Dipartimento di Scienze Motorie e Riabilitative, Facolta di Medicina e; Chirurgia, University of Genoa, Italy.; BACKGROUND: In allergic asthma, CD4+ T lymphocytes are a fundamental component of local chronic inflammation. Their cytokine profile is oriented toward a TH2 phenotype, characterized by production of IL-4, IL-5, IL-10, and IL-13. Egress of T cells from blood to airways after allergen challenge has been described. OBJE
Cyclosporine restores cytokine imbalance in childhood atopic dermatitis.: J Allergy Clin Immunol. 1997 Jun;99(6 Pt 1):857-9. Unique Identifier : AIDSLINE MED/97358139; Campbell DE; Kemp AS; Department of Immunology, Royal Children's Hospital, Melbourne,; Parkville, VIC, Australia.
High prevalence and coinfection rate of hepatitis G and C infections in intravenous drug addicts.: J Hepatol. 1997 Apr;26(4):794-7. Unique Identifier : AIDSLINE MED/97271946; Diamantis I; Bassetti S; Erb P; Ladewig D; Gyr K; Battegay M; Outpatient Department of Internal Medicine, University of Basel,; Switzerland.; BACKGROUND/AIMS: The hepatitis G virus is a newly discovered RNA virus which is possibly transmitted parenterally. Hepatitis G virus is associated with acute or chronic hepatitis and may lead to cirrhosis and liver cancer, characteristics shared by the hepatitis C virus. Hepatitis C virus is prevalent in drug users, b
Activism and marginalization in the AIDS crisis.: J Homosex. 1997;32(3-4):1-16. Unique Identifier : AIDSLINE MED/97292749; Hallett MA; Department of Criminal Justice, Middle Tennessee State University,; USA.
The problem with making AIDS comfortable: federal policy making and the rhetoric of innocence.: J Homosex. 1997;32(3-4):115-44. Unique Identifier : AIDSLINE MED/97292753; Donovan MC; Department of Political Science, University of Washington, Seattle; 98195, USA.; This essay presents a narrative of U.S. AIDS policy which highlights the ways that people with AIDS (PWAs) have been categorized throughout the epidemic. I argue that PWAs have been broadly categorized as either innocent or guilty in the public discourse about AIDS, and that these distinctions have greatly influen
A citizens' AIDS Task Force: overcoming obstacles.: J Homosex. 1997;32(3-4):145-67. Unique Identifier : AIDSLINE MED/97292754; Aiken JH; School of Law, University of South Carolina, Columbia 29208, USA.; This article analyzes the experience of a state-wide Task Force on AIDS using grassroots techniques to construct policy responsive to the needs of people living with HIV. The four primary obstacles to effective policy making were the need (1) to include disenfranchised groups; (2) to avoid the domination of government
AIDS and the new medical gaze: bio-politics, AIDS, and homosexuality.: J Homosex. 1997;32(3-4):169-84. Unique Identifier : AIDSLINE MED/97292755; Dennis D; Department of Criminal Justice, Texas A & M International University,; Laredo 78041-1499, USA. ddennis@icsi.net; The essay argues that the contemporary resurgence of homophobia and the remedicalization of homosexuals in the wake of AIDS is, in part, an unintended but predictable effect of a quarter century of fractious identity-politics. Prominent gay and lesbian political strategies of the 1970s and 1980s borrowed heavily from
Gatekeeping through media format: strategies of voice for the HIV-positive via human interest news formats and organizations.: J Homosex. 1997;32(3-4):17-36. Unique Identifier : AIDSLINE MED/97292750; Hallett MA; Cannella D; Department of Criminal Justice Administration, Middle Tennessee State; University, Murfreesboro, TN 37132, USA.; This research examines the extent to which HIV-positive voices are marginalized in the mainstream versus the alternative press. The central claim of this research is that news media format considerations, constructed around what has come to be called media logic, leave persons who are HIV-positive with comparative
Truth and deception in AIDS information brochures.: J Homosex. 1997;32(3-4):37-75. Unique Identifier : AIDSLINE MED/97292751; Jones A; Arizona State University, USA.; This essay documents state governmental subversion of expansive constructions of HIV-disease. While it is clear that governments frequently practice deception and secrecy with the justification that the public would become dangerously emotional and irrational if fully informed, there is no evidence that the public wou
The social construction of target populations and the transformation of prison-based AIDS policy: a descriptive case study.: J Homosex. 1997;32(3-4):77-114. Unique Identifier : AIDSLINE MED/97292752; Hogan NL; Department of Sociology, Morehead State University, KY 40351, USA.; n.hogan@moreheadst.edu; When interpreting policy changes, it is important to understand the social construction of those whom the policy affects. Policy Design Perspective by Schneider and Ingram (1993) concentrates on the construction of agents and targets in an attempt to comprehend policy formation and transformation. The following de
Differential development of CD4 and CD8 cytotoxic T cells (CTL) in PBMC across the leprosy spectrum; IL-6 with IFN-gamma or IL-2 generate CTL in multibacillary patients.: Int J Lepr Other Mycobact Dis. 1997 Mar;65(1):45-55. Unique Identifier : AIDSLINE MED/97351471; de la Barrera S; Finiasz DM; Fink S; Valdez R; Bottasso O; Balina LM; Sasiain MC; Departamento Inmunologia, Instituto de Investigaciones Hematologicas,; Academia Nacional de Medicina, Buenos Aires, Argentina.; In the present study we evaluated the contribution of CD4 and CD8 T cells on the antigen-specific cytotoxic activity induced by whole Mycobacterium leprae in leprosy patients and normal controls (N) as well as the modulation of this activity by some cytokines. Peripheral blood mononuclear cells (PBMC) from N or from l
Evidence for the existence of ganglioside-enriched plasma membrane domains in human peripheral lymphocytes.: J Lipid Res. 1997 May;38(5):969-80. Unique Identifier : AIDSLINE MED/97330455; Sorice M; Parolini I; Sansolini T; Garofalo T; Dolo V; Sargiacomo M; Tai T; Peschle C; Torrisi MR; Pavan A; Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma; La Sapienza, Italy.; In human peripheral blood lymphocytes (PBL) monosialoganglioside GM3 appears to be the major ganglioside on the cell plasma membrane. We have analyzed the expression and distribution pattern of GM3 molecules on the lymphocyte plasma membrane by flow cytometry, immunofluorescence, and immunoelectron microscopy, using a
Rapid and sensitive detection of cell-associated HIV-1 in latently infected cell lines and in patient cells using sodium-n-butyrate induction and RT-PCR.: J Med Virol. 1997 Jun;52(2):179-89. Unique Identifier : AIDSLINE MED/97323277; Kashanchi F; Melpolder JC; Epstein JS; Sadaie MR; Laboratory of Molecular Virology, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland, USA.; To develop a rapid and sensitive means of detecting cell-associated human immunodeficiency virus (HIV), donor cells from HIV seropositive patients were treated with the potent viral activator sodium-n-butyrate (NaB) and subsequently assayed by both in situ RNA hybridization and a reverse transcriptase polymerase chain
Quantity of cytomegalovirus viruria is a major risk factor for cytomegalovirus disease after renal transplantation.: J Med Virol. 1997 Jun;52(2):200-5. Unique Identifier : AIDSLINE MED/97323280; Cope AV; Sweny P; Sabin C; Rees L; Griffiths PD; Emery VC; Department of Virology, Royal Free Hospital School of Medicine,; London, UK.; Studies have shown that risk factors for human cytomegalovirus HCMV) disease after renal transplant include primary infection virus of donor origin infecting a non-immune individual), re-infection (virus of donor origin infecting a immune individual), and the detection of viraemia
Sinusitis in HIV-infected patients.: J Chemother. 1997 Apr;9(2):83-8. Unique Identifier : AIDSLINE MED/97319857; Del Borgo C; Del Forno A; Ottaviani F; Fantoni M; Department of Infectious Diseases, Catholic University, Rome, Italy.; The purpose of this study is to retrospectively review the clinical, radiographic and laboratory characteristics, the therapy and evolution of sinusitis in HIV-infected patients hospitalized between January 1, 1985 and July 31, 1994. We have observed 65 cases of sinusitis in 58 HIV-infected patients (77.6% classified
Evolution of AIDS and AIDS related malignancies in pediatric patients in the United States.: J Nihon Univ Sch Dent. 1997 Mar;39(1):8-11. Unique Identifier : AIDSLINE MED/97342213; Parmley RT; Department of Pediatrics, Carolinas Medical Center, University of; North Carolina 28232-2861, USA.; The pediatric AIDS epidemic began in the U.S.A. between 1983 and 1985. Hemophilia patients were among the first victims of this disease with the majority of these patients infected prior to 1984. At the South Texas Hemophilia Center 69 of 108 patients less than 21 years of age demonstrated serologic evidence of infect
A call for universal health coverage [letter; comment] [corrected and republished in J Okla State Med Assoc 1997 Jul-Aug;90(6):342-3]: J Okla State Med Assoc. 1997 May-Jun;90(5):199-200. Unique Identifier : AIDSLINE MED/97347623; Dewberry GP
Histological and immunochemical studies of oral leukoplakia: phenotype and distribution of immunocompetent cells.: J Philipp Dent Assoc. 1995 Jun-Aug;47(1):3-18. Unique Identifier : AIDSLINE MED/97370840; Bondad-Palmario GG; Dept. of Second Oral and Maxillofacial Surgery, Faculty of Dentistry,; Tokyo Medical & Dental University.; The Phenotype and distribution of immunocompetent cells in oral leukoplakia with different levels of dysplasia were analyzed. Cells were identified in two compartments of the oral mucosa, the epithelium and subepithelial connective tissue. One hundred cases of neutral-buffered formalin-fixed paraffin embedded biopsy m
Periodontal conditions in HIV/AIDS patients. A short review.: J N Z Soc Periodontol. 1995;(79):8-10. Unique Identifier : AIDSLINE MED/97370823; Robertson T; School of Dentistry, University of Dentistry, Dunedin.
Impact of HIV risk and infection and the role of prevention services.: J Subst Abuse Treat. 1996 Sep-Oct;13(5):375-85; discussion 439. Unique Identifier : AIDSLINE MED/97287576; Watters JK; Institute for Health Policy Studies, University of California, San; Francisco 94143-1304, USA.; Blood-borne infection associated with injection drug use is a significant cause of morbidity and mortality. Over the last decade, HIV infection and its clinical sequelae have had a significant impact on research and interventions involving injecting drug users (IDUs) in the United States
Impact of HIV risk and infection on delivery of psychosocial treatment services in outpatient programs.: J Subst Abuse Treat. 1996 Sep-Oct;13(5):387-95; discussion 439. Unique Identifier : AIDSLINE MED/97287577; Sorensen JL; Miller MS; University of California, San Francisco, USA.; HIV risk and HIV infection have profoundly affected the delivery of psychosocial treatment services in outpatient drug treatment settings. First, HIV has changed the programmatic emphasis of outpatient treatment, from the intake process through the goals of care, and treatment program staff are being altered significa
The impact of HIV infection on medical services in drug abuse treatment programs.: J Subst Abuse Treat. 1996 Sep-Oct;13(5):397-410; discussion 439. Unique Identifier : AIDSLINE MED/97287578; Selwyn PA; AIDS Program, Yale University, School of Medicine, New Haven, CT; 06510-2483, USA.; The HIV/AIDS epidemic has had a profound impact on the organization and delivery of clinical services in drug abuse treatment programs. The need for emphasis on HIV prevention vs. treatment services has varied with the geographic distribution of HIV infection among drug injectors. On-site primary medical care services
Therapeutic communities: AIDS/HIV risk and harm reduction.: J Subst Abuse Treat. 1996 Sep-Oct;13(5):411-20; discussion 439. Unique Identifier : AIDSLINE MED/97287579; De Leon G; Center for Therapeutic Community Research, National Development and; Research Institutes, Inc., New York, NY 10048, USA.; The limited survey data available suggest that therapeutic communities have increasingly organized themselves to develop HIV prevention programs and to integrate HIV-infected and AIDS clients into the treatment community while providing specialized program as necessary. Nonetheless, there remains a need for a comprehe
HIV risk reduction and service delivery strategies in criminal justice settings.: J Subst Abuse Treat. 1996 Sep-Oct;13(5):421-8; discussion 439. Unique Identifier : AIDSLINE MED/97287580; Inciardi JA; Center for Drug and Alcohol Studies, University of Delaware, Newark; 19716-2582, USA.; Because of the HIV risk behaviors of substance abusers, particularly injection drug users and those who exchange sex for drugs, and the large numbers who are already infected with HIV or showing symptoms of AIDS, significant service delivery issues are associated with their criminal justice processing. Many strategies
Substance abuse treatment and HIV services: Massachusetts' policies and programs.: J Subst Abuse Treat. 1996 Sep-Oct;13(5):429-38; discussion 439. Unique Identifier : AIDSLINE MED/97287581; McCarty D; LaPrade J; Botticelli M; Institute for Health Policy, Brandeis University, Waltham, MA 02254,; USA.; States and communities use many strategies and policies to facilitate the integration of HIV and AIDS services with alcoholism and drug abuse treatment and prevention programs. Massachusetts policy initiatives that promoted collaboration between substance abuse programs and AIDS services are outlined. The review begi
Consensus statements from conference on AIDS/HIV infection and drug abuse treatment.: J Subst Abuse Treat. 1996 Sep-Oct;13(5):441. Unique Identifier : AIDSLINE MED/97287582
Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection.: J Virol. 1997 Aug;71(8):5713-22. Unique Identifier : AIDSLINE MED/97366627; Kitchen SG; Uittenbogaart CH; Zack JA; Department of Microbiology and Immunology, University of California; Los Angeles School of Medicine, 90095, USA.; Human immunodeficiency virus (HIV) infection of the thymus could have profound effects on development of the immune response, particularly in children. We and others have established that in addition to infecting and depleting CD4-bearing thymocytes, functional HIV proviruses are found in thymocytes lacking surface CD
Blocking of feline immunodeficiency virus infection by a monoclonal antibody to CD9 is via inhibition of virus release rather than interference with receptor binding.: J Virol. 1997 Aug;71(8):5742-9. Unique Identifier : AIDSLINE MED/97366630; de Parseval A; Lerner DL; Borrow P; Willett BJ; Elder JH; Department of Molecular Biology, The Scripps Research Institute, La; Jolla, California 92037, USA.; A monoclonal antibody, MAb vpg15, inhibits feline immunodeficiency virus (FIV) infection in tissue culture. The antibody is directed to a determinant of the feline cell surface marker, CD9, implying that CD9 may serve as a viral receptor or coreceptor in this system. In cells expressing CD9, MAb vpg15 markedly delayed
The importance of the A-rich loop in human immunodeficiency virus type 1 reverse transcription and infectivity.: J Virol. 1997 Aug;71(8):5750-7. Unique Identifier : AIDSLINE MED/97366631; Liang C; Li X; Rong L; Inouye P; Quan Y; Kleiman L; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish General; Hospital, Montreal, Quebec, Canada.; Nucleotide segment (+169)AAAA(+172) constitutes an A-rich loop within human immunodeficiency virus type 1 (HIV-1) (HXB2D) RNA and is able to interact with the anticodon loop (33)/USUU(36) of primer tRNA3(Lys). We have shown that the deletion of this A-rich loop resulted in diminished levels of infectivity and reduced
Human immunodeficiency virus type 1 (HIV-1) protein Vif inhibits the activity of HIV-1 protease in bacteria and in vitro.: J Virol. 1997 Aug;71(8):5774-81. Unique Identifier : AIDSLINE MED/97366635; Kotler M; Simm M; Zhao YS; Sova P; Chao W; Ohnona SF; Roller R; Krachmarov C; Potash MJ; Volsky DJ; Department of Molecular Genetics, Hadassah Medical School, Hebrew; University, Jerusalem, Israel.; Human immunodeficiency virus type 1 (HIV-1) Vif is required for productive infection of T lymphocytes and macrophages. Virions produced in the absence of Vif have abnormal core morphology and those produced in primary T cells carry immature core proteins and low levels of mature capsid (M. Simm, M. Shahabuddin, W. Cha
Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus.: J Virol. 1997 Aug;71(8):5790-8. Unique Identifier : AIDSLINE MED/97366637; Flaherty MT; Hauer DA; Mankowski JL; Zink MC; Clements JE; Division of Comparative Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; To identify the molecular determinants of neurovirulence, we constructed an infectious simian immunodeficiency virus (SIV) molecular clone, SIV/17E-Fr, that contained the 3 end of a neurovirulent strain of SIV, SIV/17E-Br, derived by in vivo virus passage. SIV/17E-Fr is macrophage tropic in vitro and neurovirulent in
Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46.: J Virol. 1997 Aug;71(8):5828-40. Unique Identifier : AIDSLINE MED/97366642; Hadlock KG; Rowe J; Perkins S; Bradshaw P; Song GY; Cheng C; Yang J; Gascon R; Halmos J; Rehman SM; McGrath MS; Foung SK; Department of Pathology, Stanford University School of Medicine,; California 94305, USA. k.g.hadlock@forsythe.stanford.edu; Ten human monoclonal antibodies derived from peripheral B cells of a patient with human T-cell lymphotropic virus HTLV)-associated myelopathy are described. One monoclonal antibody recognized a linear epitope within the carboxy-terminal 43 amino acids of HTLV gp21, and two monoclonal antibodies recognized linear epito
The effect of viral regulatory protein expression on gene delivery by human immunodeficiency virus type 1 vectors produced in stable packaging cell lines.: J Virol. 1997 Aug;71(8):5841-8. Unique Identifier : AIDSLINE MED/97366643; Srinivasakumar N; Chazal N; Helga-Maria C; Prasad S; Hammarskjold ML; Rekosh D; Myles H. Thaler Center for AIDS and Human Retrovirus Research and; Department of Microbiology, University of Virginia, Charlottesville; 22908, USA.; We describe the generation of stable human immunodeficiency virus type 1 (HIV-1)-packaging lines that constitutively express high levels of HIV-1 structural proteins in either a Rev-dependent or a Rev-independent fashion. These cell lines were used to assess gene transfer by using an HIV-1 vector expressing the hygrom
Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.: J Virol. 1997 Aug;71(8):6003-10. Unique Identifier : AIDSLINE MED/97366661; Li X; Liang C; Quan Y; Chandok R; Laughrea M; Parniak MA; Kleiman L; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, and Department; of Medicine, McGill University, Montreal, Quebec, Canada.; Reverse transcription of retroviruses is initiated from an 18-nucleotide (nt) primer binding site (PBS), located within the 5 region of viral genomic RNA, to which the host cell-derived tRNA primer is annealed and also involves viral genomic sequences outside the PBS. We constructed proviral DNA clones of human immun
Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody.: J Virol. 1997 Aug;71(8):6037-43. Unique Identifier : AIDSLINE MED/97366665; Lee S; Peden K; Dimitrov DS; Broder CC; Manischewitz J; Denisova G; Gershoni JM; Golding H; Division of Viral Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.; The entry of human immunodeficiency virus type 1 (HIV-1) into cells is initiated by binding of the viral glycoprotein gp120-gp41 to its cellular receptor CD4. The gp120-CD4 complex formed at the cell surface undergoes conformational changes that may allow its association with an additional membrane component(s) and th
Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence.: J Virol. 1997 Aug;71(8):6055-60. Unique Identifier : AIDSLINE MED/97366668; Mankowski JL; Flaherty MT; Spelman JP; Hauer DA; Didier PJ; Amedee AM; Murphey-Corb M; Kirstein LM; Munoz A; Clements JE; Zink MC; Department of Pathology, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; To examine the relationship between macrophage tropism and neurovirulence, macaques were inoculated with two recombinant hybrid viruses derived from the parent viruses SIVmac239, a lymphocyte-tropic, non-neurovirulent clone, and SIV/17E-Br, a macrophage-tropic, neurovirulent virus strain. The first recombinant, SIV/17
A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.: J Virol. 1997 Aug;71(8):6094-9. Unique Identifier : AIDSLINE MED/97366673; Alexander L; Du Z; Rosenzweig M; Jung JU; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9102, USA.; A T-lymphoid cell line termed 221 was derived from a rhesus monkey infected with herpesvirus saimiri. Growth of 221 cells was dependent on the addition of interleukin-2 ( IL-2 ) to the culture medium. In the absence of IL-2, 221 cells arrested in G0-G1 but did not die. S
Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.: J Virol. 1997 Aug;71(8):6113-27. Unique Identifier : AIDSLINE MED/97366676; Van Lint C; Amella CA; Emiliani S; John M; Jie T; Verdin E; The Picower Institute for Medical Research, Manhasset, New York 11030,; USA.; When transcriptionally active, the human immunodeficiency virus HIV) promoter contains a nucleosome-free region encompassing both the promoter/enhancer region and a large region (255 nucleotides [nt]) downstream of the transcription start site. We have previously identified new binding sites for transcription factors
Sensitization of rhabdo-, lenti-, and spumaviruses to human serum by galactosyl(alpha1-3)galactosylation.: J Virol. 1997 Aug;71(8):6174-8. Unique Identifier : AIDSLINE MED/97366682; Takeuchi Y; Liong SH; Bieniasz PD; Jager U; Porter CD; Friedman T; McClure MO; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research, London,; England. yasuhiro@icr.ac.uk; Vesicular stomatitis virus, human immunodeficiency virus type 2, and human foamy virus, which were produced by cell lines expressing galactosyl(alpha1-3)galactosyl (alphaGal) sugars, were found to be less stable in human serum than those from alphaGal-negative cells, indicating that galactosyl(alpha1-3)galactosylation
Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.: J Virol. 1997 Aug;71(8):6225-9. Unique Identifier : AIDSLINE MED/97366692; Carteau S; Batson SC; Poljak L; Mouscadet JF; de Rocquigny H; Darlix JL; Roques BP; Kas E; Auclair C; Laboratoire de Physicochimie et Pharmacologie des Macromolecules; Biologiques, CNRS URA 147, Institut Gustave Roussy, Villejuif, France.; The integrase (IN) protein of the human immunodeficiency virus mediates integration of the viral DNA into the cellular genome. In vitro, this reaction can be mimicked by using purified recombinant IN and model DNA substrates. IN mediates two reactions: an endonucleolytic cleavage at each 3 end of the proviral DNA (te
Upregulation of human immunodeficiency virus (HIV) replication by CD4 cross-linking in peripheral blood mononuclear cells of HIV-infected adults.: J Virol. 1997 Aug;71(8):6230-2. Unique Identifier : AIDSLINE MED/97366693; Than S; Oyaizu N; Tetali S; Romano J; Kaplan M; Pahwa S; Department of Pediatrics, North Shore University Hospital-New York; University School of Medicine, Manhasset 11030, USA.; This study was conducted with peripheral blood mononuclear cells from 67 human immunodeficiency virus (HIV)-infected adults. It supports the hypothesis that cross-linking of CD4 molecules by HIV gp120 can result in HIV upregulation and spread of infection. Underlying mechanisms include activation of latent infection b
Molecular characterization and phylogenetic analyses of a new, highly divergent simian T-cell lymphotropic virus type 1 STLV-1marc1) in Macaca arctoides.: J Virol. 1997 Aug;71(8):6253-8. Unique Identifier : AIDSLINE MED/97366698; Mahieux R; Pecon-Slattery J; Gessain A; Departement des Retrovirus, Institut Pasteur, Paris, France.; A serological survey of a captive colony of Asian monkeys indicated that six Macaca arctoides had antibodies to human T-cell leukemia/lymphotropic viruses (HTLV). Over a 4-year interval, sera from these animals continued to exhibit a peculiar Western blot (WB) pattern resembling an HTLV-2 pattern (p24gag reactivity of
High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors.: J Virol. 1997 Aug;71(8):6271-5. Unique Identifier : AIDSLINE MED/97366702; Gupta P; Mellors J; Kingsley L; Riddler S; Singh MK; Schreiber S; Cronin M; Rinaldo CR; Department of Infectious Diseases and Microbiology, Graduate School of; Public Health, University of Pittsburgh, and Veterans Affairs Medical; Center, Pennsylvania, USA. pguptal@vms.cis.pitt.edu; Seminal viral load is likely to be directly related to the sexual transmissibility of human immunodeficiency virus type 1 (HIV-1). However, it is not clear whether the level of HIV-1 in semen varies with the stage of infection and whether antiretroviral therapy reduces seminal viral load. A nucleic acid sequence-based
Criteria for screening blood donors: science or politics? [letter; comment]: JAMA. 1997 Jul 23-30;278(4):289. Unique Identifier : AIDSLINE MED/97372164; Murphy JL
Surveillance for variant strains of HIV: subtype G and group O HIV-1 [letter]: JAMA. 1997 Jul 23-30;278(4):292. Unique Identifier : AIDSLINE MED/97372169; Sullivan PS; Do AN; Robbins K; Kalish M; Subbarao S; Pieniazek D; Schable C; Afaq G; Markowitz J; Myers R; Joseph JM; Benjamin G
Preventing opportunistic infections in persons infected with HIV: 1997 guidelines [editorial]: JAMA. 1997 Jul 23-30;278(4):337-8. Unique Identifier : AIDSLINE MED/97372179; Kaplan JE; Masur H; Jaffe HW; Holmes KK
The controversy surrounding the pathogenesis of the multiple sclerosis lesion.: Mayo Clin Proc. 1997 Jul;72(7):665-78. Unique Identifier : AIDSLINE MED/97356336; Lucchinetti CF; Rodriguez M; Department of Neurology, Mayo Clinic Rochester, Minnesota 55905, USA.; The main issues in multiple sclerosis research revolve around four fundamental questions. (1) What initiates the disease-that is, autoimmune T cells, a virus, or a toxin? (2) Is the inflammatory response primary to the development of demyelination, or is it a secondary response to injury? (3) Is the oligodendrocyte, t
Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group.: Lancet. 1997 Jun 28;349(9069):1868-73. Unique Identifier : AIDSLINE MED/97360795; Cohen MS; Hoffman IF; Royce RA; Kazembe P; Dyer JR; Daly CC; Zimba D; Vernazza PL; Maida M; Fiscus SA; Eron JJ Jr; Department of Medicine, University of North Carolina, Chapel Hill; 27599-7030, USA. mscohen@med.unc.edu; BACKGROUND: Transmission of HIV-1 is predominantly by heterosexual contact in sub-Saharan Africa, where sexually transmitted diseases (STDs) are also common. Epidemiological studies suggest that STDs facilitate transmission of HIV-1, but the biological mechanism remains unclear. We investigated the hypothesis that STD
USA outlines standard of care for HIV/AIDS [news]: Lancet. 1997 Jun 28;349(9069):1891. Unique Identifier : AIDSLINE MED/97360806; Ault A
Invasive cervical cancer after treatment for cervical intraepithelial neoplasia [letter; comment]: Lancet. 1997 Jun 28;349(9069):1909-10. Unique Identifier : AIDSLINE MED/97360811; Vaccher E; Tirelli U
AIDS epidemic in Kaliningrad [letter]: Lancet. 1997 Jun 28;349(9069):1914-5. Unique Identifier : AIDSLINE MED/97360822; Leinikki P
The effect of 1,25(OH)2 vitamin D3 on CD4+/CD8+ subsets of T lymphocytes in postmenopausal women.: Life Sci. 1997;61(2):147-52. Unique Identifier : AIDSLINE MED/97360245; Zofkova I; Kancheva RL; Institute of Endocrinology, Prague, Czech Republic.; The effect of exogenous 1,25(OH)2 vitamin D3 (1,25(OH)2D3) on the CD3+, CD4+ and CD8+ subsets (counts/ul) of T lymphocytes was investigated in two randomized groups of postmenopausal women. Group one (16 subjects) received 1 ug/day of the secosteroid for 14 days, while group two (14 participants) was treated with 2 ug
Thiadiazole derivatives: highly potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replications in vitro.: Microbiol Immunol. 1997;41(4):301-8. Unique Identifier : AIDSLINE MED/97302972; Fujiwara M; Ijichi K; Hanasaki Y; Ide T; Katsuura K; Takayama H; Aimi N; Shigeta S; Konno K; Yokota T; Baba M; Rational Drug Design Laboratories, Matsukawa-machi, Fukushima, Japan.; We have recently reported that thiadiazole (TDA) derivatives are highly potent inhibitors of human immunodeficiency virus type 1 HIV-1) replication. These compounds belong to the family of nonnucleoside reverse transcriptase inhibitors (NNRTIs). In an attempt to develop more effective and pharmacologically favorable c
Breast milk is not a significant source for early Epstein-Barr virus or human herpesvirus 6 infection in infants: a seroepidemiologic study in 2 endemic areas of human T-cell lymphotropic virus type I in Japan.: Microbiol Immunol. 1997;41(4):309-12. Unique Identifier : AIDSLINE MED/97302973; Kusuhara K; Takabayashi A; Ueda K; Hidaka Y; Minamishima I; Take H; Fujioka K; Imai S; Osato T; Department of Pediatrics, Faculty of Medicine, Kyushu University,; Higashi-ku, Fukuoka, Japan.; In order to evaluate the possibility of Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) transmission via breast milk, a total of 331 serum specimens collected from bottle-fed and breast-fed children and their mothers, in 2 endemic areas of human T-cell lymphotropic virus type I (HTLV-I) in
Presence of IgM antibodies which sensitize HIV-1-infected cells to cytolysis by homologous complement in long-term survivors of HIV infection.: Microbiol Immunol. 1997;41(4):331-6. Unique Identifier : AIDSLINE MED/97302976; Okada N; Wu X; Okada H; Department of Molecular Biology, Nagoya City University School of; Medicine, Nagoya, Aichi, Japan.; Although human cells are resistant to homologous human complement due to the presence of species-specific membrane inhibitors, a naturally occurring IgM antibody which recognizes an asialo-oligosaccharide can sensitize HIV-1-infected cells for complement-mediated cytolysis. Therefore, we investigated whether long-term
Sexually transmitted diseases and unwanted pregnancies in chronically ill psychiatric patients [letter; comment]: Med J Aust. 1997 Jun 16;166(12):666. Unique Identifier : AIDSLINE MED/97359675; Thompson SC; Hocking BM; Checkley GE; Crofts N; Mijch AM; Judd FK
Why aren't all pregnant women being tested for HIV? [letter; comment]: Med J Aust. 1997 Jun 16;166(12):670-1. Unique Identifier : AIDSLINE MED/97359680; Collignon PJ; Watson DA
Prolonged poliovirus excretion in an immunodeficient person with vaccine-associated paralytic poliomyelitis.: MMWR Morb Mortal Wkly Rep. 1997 Jul 18;46(28):641-3. Unique Identifier : AIDSLINE MED/97376780; Recently completed molecular studies of poliovirus isolates suggest that viral replication of vaccine-related polioviruses may have persisted for as long as 7 years in a patient with vaccine-associated paralytic poliomyelitis (VAPP) in whom common variable immunodeficiency syndrome (CVID) previously had been diagnosed
A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group.: N Engl J Med. 1997 Jul 31;337(5):307-14. Unique Identifier : AIDSLINE MED/97365040; Rolfs RT; Joesoef MR; Hendershot EF; Rompalo AM; Augenbraun MH; Chiu M; Bolan G; Johnson SC; French P; Steen E; Radolf JD; Larsen S; Division of STD Prevention, National Center for HIV, STD, and; Tuberculosis Prevention, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA.; BACKGROUND: Reports of neurosyphilis and invasion of cerebrospinal fluid by Treponema pallidum in patients with human immunodeficiency virus (HIV) infection have led to doubts about the adequacy of the recommended penicillin G benzathine therapy for early syphilis. METHODS: In a multicenter, randomized, double-blind t
A controlled trial of isoniazid in persons with anergy and human immunodeficiency virus infection who are at high risk for tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS.: N Engl J Med. 1997 Jul 31;337(5):315-20. Unique Identifier : AIDSLINE MED/97365041; Gordin FM; Matts JP; Miller C; Brown LS; Hafner R; John SL; Klein M; Vaughn A; Besch CL; Perez G; Szabo S; El-Sadr W; Medical Service, Veterans Affairs Medical Center, and Georgetown; University, Washington, D.C. 20422, USA.; BACKGROUND: Patients with human immunodeficiency virus (HIV) infection and latent tuberculosis are at substantial risk for the development of active tuberculosis. As a public health measure, prophylactic treatment with isoniazid has been suggested for HIV-infected persons who have anergy and are in groups with a high
Transmission of the human immunodeficiency virus and the hepatitis C virus [letter; comment]: N Engl J Med. 1997 Jul 31;337(5):348-9. Unique Identifier : AIDSLINE MED/97365056; Biron F; Verrier B; Peyramond D
[Diversity in the clinical course of toxoplasma encephalitis in two patients infected with human immunodeficiency virus (HIV)]: Neurol Neurochir Pol. 1997 Jan-Feb;31(1):161-8. Unique Identifier : AIDSLINE MED/97343593; Rogowska-Szadkowska D; Borzuchowska A; Prokopowicz D; Grzeszczuk A; Kuklik N; Kliniki Obserwacyjno-Zakaznej Akademii Medycznej w Bialymstoku.; The central nervous system (CNS) is the most common site of Toxoplasma gondii infection in HIV-positive patients, mainly due to reactivation of Toxoplasma cysts. The diagnosis is difficult since no sensitive and specific non-invasive diagnostic tests exist. The patient may present with rather unspecific signs and symp
In vitro antifungal resistance of oral Candida albicans strains in non-AIDS patients.: Oral Microbiol Immunol. 1997 Apr;12(2):126-8. Unique Identifier : AIDSLINE MED/97370870; Monteil RA; Madinier I; Le Fichoux Y; Laboratoire de Pathobiologie Orale, Faculte de Chirurgie-Dentaire,; Universite de Nice-Sophia Antipolis, France.; Some cases of oral candidosis are refractory to antifungal treatment. This might be related to development of resistant Candida strains, but susceptibility testing is not standardized and not routinely available, and information related to this problem is scarce in non-AIDS patients. In this study, the in vitro antifu
Leiomyosarcoma of the kidney in an HIV-infected child.: Pediatr Radiol. 1997 Jun;27(6):557-8. Unique Identifier : AIDSLINE MED/97319005; Norton KI; Godine LB; Lempert C; Department of Radiology, Mount Sinai Hospital, Box 1234, 1 Gustave L.; Levy Place, New York, NY 10029, USA.; Spindle cell tumors (leiomyoma and leiomyosarcoma) have been described in immunocompromised children after transplantation and in association with HIV infection. Previous reports have described tumors of respiratory (lung, bronchi), gastrointestinal stomach, bowel, liver), and subcutaneous origins. We report a case of
Penetration of dapsone into lung of human immunodeficiency virus-infected children.: Pediatr Infect Dis J. 1997 May;16(5):523-4. Unique Identifier : AIDSLINE MED/97299148; Gatti G; Loy A; Lorusso C; Rossi G; Bassetti D; I Department of Infectious Diseases, University of Genoa, Italy.
Clinical manifestations of human immunodeficiency virus infection in Haitian children.: Pediatr Infect Dis J. 1997 Jun;16(6):600-6. Unique Identifier : AIDSLINE MED/97337371; Jean SS; Reed GW; Verdier RI; Pape JW; Johnson WD; Wright PF; Cornell University Infectious Diseases Research Unit, Cornell; University Medical College, New York, NY, USA.; OBJECTIVE: This study was designed to describe the characteristics of HIV-1 infection in children in Haiti and to assess its impact on morbidity and mortality. BACKGROUND: Throughout the developing world the female-to-male ratio of HIV-1 infection approaches 1:1, leading to a tremen
Lifetime cost of care for children with human immunodeficiency virus infection.: Pediatr Infect Dis J. 1997 Jun;16(6):607-10. Unique Identifier : AIDSLINE MED/97337372; Havens PL; Cuene BE; Holtgrave DR; Department of Pediatrics, Medical College of Wisconsin, Milwaukee,; USA.; BACKGROUND: Knowledge of the cost of care for children with HIV infection is necessary to analyze the economic impact of recommendations for universal counseling and voluntary HIV testing of pregnant women. OBJECTIVES: To estimate the total cost of care for children with HIV infection. METHODS: We performed a retrospe
Toxoplasmosis of the central nervous system in non-human immunodeficiency virus-infected children: case report and review of the literature.: Pediatr Infect Dis J. 1997 Jun;16(6):611-8. Unique Identifier : AIDSLINE MED/97337373; Khan EA; Correa AG; Department of Pediatrics, Baylor College of Medicine, Houston, TX,; USA.
Comparative trial of two dosages of zalcitabine in zidovudine-experienced children with advanced human immunodeficiency virus disease. Pediatric AIDS Clinical Trials Group.: Pediatr Infect Dis J. 1997 Jun;16(6):623-6. Unique Identifier : AIDSLINE MED/97337375; Spector SA; Blanchard S; Wara DW; Oleske JM; McIntosh K; Hodes D; Dankner WM; Salgo M; McNamara J; University of California, San Diego, La Jolla, USA.
Cytokine-induced expression of CD1b molecules by peripheral blood monocytes: influence of 3'-azido-3'-deoxythymidine.: Pharmacol Res. 1997 Feb;35(2):135-40. Unique Identifier : AIDSLINE MED/97318646; Giuliani A; Tentori L; Pepponi R; Porcelli SA; Aquino A; Orlando L; Sugita M; Brenner MB; Bonmassar E; Graziani G; Department of Experimental Medicine and Biochemical Sciences,; University of Rome Tor Vergata, Italy.; CD1b is a nonpolymorphic, MHC-like molecule, capable of presenting non-peptide antigens (Ags) to CD3+, CD4-, CD8-, alphabeta or gammadelta T lymphocytes. Previous studies have shown that CD1b can be induced in monocytes/macrophages by GM-CSF+IL-4, and can restrict their presentation of Mycobacterium tuberculosis antig
Lower serum dipeptidyl peptidase IV activity in treatment resistant major depression: relationships with immune-inflammatory markers.: Psychoneuroendocrinology. 1997 Feb;22(2):65-78. Unique Identifier : AIDSLINE MED/97293356; Maes M; De Meester I; Verkerk R; De Medts P; Wauters A; Vanhoof G; Vandoolaeghe E; Neels H; Scharpe S; University Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium.; Previous research in this laboratory has shown that major depression is accompanied by decreased serum activity of dipeptidyl peptidase IV (DPP IV), a serine protease that cleaves N terminal dipeptides from peptides with penultimate proline or alanine. DPP IV is involved in the metabolism of peptides, T cell activatio
Granulocyte-macrophage colony-stimulating factor mouthwashes improve radiation induced mucositis in AIDS patients [letter]: Radiother Oncol. 1997 May;43(2):229-30. Unique Identifier : AIDSLINE MED/97336176; de la Torre A; Reguiero CA; Valcarcel FJ
Pulmonary manifestations of strongyloidiasis.: Semin Respir Infect. 1997 Jun;12(2):122-9. Unique Identifier : AIDSLINE MED/97339122; Wehner JH; Kirsch CM; Department of Medicine, Stanford University School of Medicine, San; Jose, CA 95128, USA.; Strongyloides stercoralis (SS) is endemic in tropical and subtropical areas worldwide and in the southeastern United States . The lifecycle of SS is both unique and complex. Human infection begins with the penetration of skin by filariform larvae that migrate hematogenously to the lungs
Diagnostic strategies for Pneumocystis carinii pneumonia.: Semin Respir Infect. 1997 Jun;12(2):70-8. Unique Identifier : AIDSLINE MED/97339117; Kroe DM; Kirsch CM; Jensen WA; Stanford University School of Medicine, CA, USA.; Pneumocystis carinii is an opportunistic organism that is a common cause of pneumonia in immunocompromised patients. Its life cycle begins when cysts rupture and release sporozoites, which mature into trophozoites that eventually form cysts. The diagnostic methods for P. carinii pneumonia (PCP) have progressed from op
Treatment of Pneumocystis carinii pneumonia in adults with AIDS.: Semin Respir Infect. 1997 Jun;12(2):79-97. Unique Identifier : AIDSLINE MED/97339118; Deresinski SC; Division of Infectious Diseases, Santa Clara Valley Medical Center,; San Jose, CA 95128, USA.; Trimethoprim-sulfamethoxazole remains the treatment of choice in patients with Pneumocystis carinii pneumonia (PCP) requiring intravenous therapy. Those patients who require intravenous therapy who cannot tolerate or who fall therapy with trimethoprim-sulfamethoxazole may be treated with either pentamidine or trimetre
Pulmonary toxoplasmosis.: Semin Respir Infect. 1997 Jun;12(2):98-105. Unique Identifier : AIDSLINE MED/97339119; Campagna AC; Division of Pulmonary and Critical Care Medicine, Deaconess Waltham; Hospital, MA 02154, USA.; With the advent of the human immunodeficiency virus (HIV) epidemic, the worldwide incidence of infections caused by Toxoplasma gondii has been rising. In this article I discuss the pathophysiology, diagnosis, and treatment of toxoplasma pneumonia. Basic research is now directed at the relationship of this organism to
Options for renal replacement therapy: special considerations.: Semin Nephrol. 1997 May;17(3):176-87. Unique Identifier : AIDSLINE MED/97308421; Becker BN; Stone WJ; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, TN 37232-2372, USA.; The number of patients coming to end-stage renal disease (ESRD) continues to increase annually, challenging the existing system of renal replacement therapy. Moreover, these patients, on average, are older at the onset of ESRD and are living longer after the initiation of renal replacement therapy. The choice of modal
Rule-based ranking schemes for antiretroviral trials.: Stat Med. 1997 May 30;16(10):1175-91. Unique Identifier : AIDSLINE MED/97323534; Bjorling LE; Hodges JS; Division of Biostatistics, School of Public Health, University of; Minnesota, Minneapolis 55414, USA.; Endpoints are a continuing source of controversy in clinical trials of antiretroviral (specifically, anti-HIV) treatments. The most visible disagreement is about the respective roles of morbidity and mortality as endpoints, and laboratory measurements as endpoints. Laboratory measurements have been intensely examined
Dual infection with HIV-1 and HIV-2 [letter]: Thorax. 1997 Jun;52(6):587-8. Unique Identifier : AIDSLINE MED/97371511; Clarke JR; Sohi DK; Maniar JK; Udwadia Z; Mitchell DM
[AIDS and immigration (letter)]: Tidsskr Nor Laegeforen. 1997 May 30;117(14):2073. Unique Identifier : AIDSLINE MED/97369054; Wessel I
[Progress and decline in Ngami]: Tidsskr Nor Laegeforen. 1997 Jun 10;117(15):2218-20. Unique Identifier : AIDSLINE MED/97369078; Boonstra E
Interleukin (IL)-2 deficiency aggravates the defect of natural killer cell activity in AIDS patients.: Thymus. 1997;24(3):147-56. Unique Identifier : AIDSLINE MED/97295808; Zerhouni B; Sanhadji K; Kehrli L; Livrozet JM; Touraine JL; Department of Transplantation and Clinical Immunology & INSERM U80,; Lyon, France.; A decrease in natural killer (NK) cell activity is a common feature of the immune dysfunction found in patients with human immunodeficiency virus (HIV)-induced acquired immune deficiency syndrome (AIDS). The present study was aimed at exploring the NK and the lymphokine-activated killer (LAK) cell activities of lympho
Post-thymic T-cell development in the rat.: Thymus. 1997;24(3):173-200. Unique Identifier : AIDSLINE MED/97295810; Kampinga J; Groen H; Klatter FA; Pater JM; van Petersen AS; Roser B; Nieuwenhuis P; Aspinall R; Department of Histology and Cell Biology, University of Groningen, The; Netherlands.; The presence or absence of CD4, CD8, Thy-1, RT6 and CD45RC revealed a number of T-cell subpopulations in the rat. Vascular thymus transplantation was used in RT7 congenics to establish the lineage relationship between these subpopulations by following phenotypic changes after thymus emigration. We found that recent th
The participation of African traditional healers in AIDS/STD prevention programmes.: Trop Doct. 1997;27 Suppl 1:56-9. Unique Identifier : AIDSLINE MED/97348772; Green EC
Umbanda healers as effective AIDS educators: case-control study in Brazilian urban slums (favelas).: Trop Doct. 1997;27 Suppl 1:60-6. Unique Identifier : AIDSLINE MED/97348773; Nations MK; de Souza MA; Department of Social Medicine, University of Harvard Medical School,; Boston, USA.; During a 12-month period (November 1994-October 1995), Afro-Brazilian Umbanda healers (Pais-de-Santo) taught 126 fellow healers from 51 Umbanda centres (terreiros) located in seven overcrowded slums (favelas) (population 104-343) in Brazil s northeast, the biomedical prevention of AIDS, including safe sex practices, a
Induction of feline immunodeficiency virus specific antibodies in cats with an attenuated Salmonella strain expressing the Gag protein.: Vaccine. 1997 Apr-May;15(6-7):587-96. Unique Identifier : AIDSLINE MED/97321753; Tijhaar EJ; Siebelink KH; Karlas JA; Burger MC; Mooi FR; Osterhaus AD; School of Biological and Medical Sciences, University of St Andrews,; Scotland.; Salmonella typhimurium aroA strains (SL3261), expressing high levels of the Gag protein of feline immunodeficiency virus (FIV) fused with maltose binding protein (SL3261-MFG), were constructed using an invertible promoter system that allows the stable expression of heterologous antigens at levels toxic for bacteria. A
Determinants and kinetics of cytokine expression patterns in lungs of vaccinated mice challenged with respiratory syncytial virus.: Vaccine. 1997 Apr-May;15(6-7):597-602. Unique Identifier : AIDSLINE MED/97321754; Tang YW; Neuzil KM; Fischer JE; Robinson FW; Parker RA; Graham BS; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, TN 37232-2605, USA.; The development of a successful respiratory syncytial virus (RSV) vaccine will be advanced by an improved understanding of the pathogenesis of natural disease and vaccine-enhanced illness. Using a murine model, we have examined cytokine message expression and cytokine secretion in lungs of mice primed with killed or l
High prevalence of GB virus C/hepatitis G virus infection among the Jewish population in Uzbekistan.: Virus Res. 1997 Apr;48(1):81-7. Unique Identifier : AIDSLINE MED/97284923; Kato T; Mizokami M; Nakano T; Kondo Y; Ohba K; Orito E; Ueda R; Mukaide M; Gurtsevitch V; Syrtsev A; Ruzibakiev R; Abdurakhnamov M; Yamashita M; Hayami M; Second Department of Medicine, Nagoya City University Medical School,; Japan.; Although a new virus, GB virus C/hepatitis G virus (GBV-C/HGV), has been isolated from patients with hepatitis by two different research groups, its prevalence in the world and pathogenesis are still unknown. In this study, 92 samples from the Jewish population of Uzbekistan we
Intracellular thiol redox status affects rat cytomegalovirus infection of vascular cells.: Virus Res. 1997 May;48(2):173-83. Unique Identifier : AIDSLINE MED/97318303; Vossen RC; Persoons MC; Slobbe-van Drunen ME; Bruggeman CA; van Dam-Mieras MC; Department of Medical Microbiology, University of Maastricht, The; Netherlands. RVOS@LMIB.AZM.NL; There is increasing evidence for cytomegalovirus ( CMV ) induced vascular pathology during acute infection in the immunocompromised host. Inflammation is involved in such processes, which is frequently associated with increased
HIV dementia and apolipoprotein E.: Acta Neurol Scand. 1997 May;95(5):315-8. Unique Identifier : AIDSLINE MED/97332747; Dunlop O; Goplen AK; Liestol K; Myrvang B; Rootwelt H; Christophersen B; Kvittingen EA; Maehlen J; Department of Infectious Diseases, Ullev~al University Hospital, Oslo,; Norway.; The effect of apolipoprotein E genotypes on the occurrence of HIV dementia and HIV encephalitis was studied in a sample of 132 AIDS patients in whom clinical data on dementia was available and full autopsy had been performed. There was no statistically significant correlation betwe
Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The Hepatitis/HIV Spanish Study Group.: Am J Gastroenterol. 1997 Jul;92(7):1130-4. Unique Identifier : AIDSLINE MED/97363491; Garcia-Samaniego J; Soriano V; Castilla J; Bravo R; Moreno A; Carbo J; Iniguez A; Gonzalez J; Munoz F; Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, and; Hospital Ramon y Cajal, Madrid, Spain.; OBJECTIVES: The factors influencing the histological severity of chronic hepatitis C (CHC) have not been well established. We therefore investigated the effect of hepatitis C virus (HCV) genotypes and human immunodeficiency virus (HIV) infection on histological liver damage in a cohort of intravenous drug users with C
Nonadherence in tuberculosis treatment: predictors and consequences in New York City.: Am J Med. 1997 Feb;102(2):164-70. Unique Identifier : AIDSLINE MED/97360602; Pablos-Mendez A; Knirsch CA; Barr RG; Lerner BH; Frieden TR; Division of General Medicine, School of Public Health, Columbia; University, New York, New York, USA.; BACKGROUND: Poor adherence to antituberculosis treatment is the most important obstacle to tuberculosis control. PURPOSE: To identify and analyze predictors and consequences of nonadherence to antituberculosis treatment. PATIENTS AND METHODS: Retrospective study of a citywide cohort of 184 patients with tuberculosis i
Prophylaxis of visceral leishmaniasis in human immunodeficiency virus-infected patients [letter; comment]: Am J Med. 1997 Feb;102(2):222. Unique Identifier : AIDSLINE MED/97360613; Laguna-del-Estal P; Moya-Mir MS
Tuberculous brain abscess in a patient with HIV infection: case report and review.: Am J Med. 1997 Mar;102(3):297-301. Unique Identifier : AIDSLINE MED/97360636; Farrar DJ; Flanigan TP; Gordon NM; Gold RL; Rich JD; Department of Medicine, Miriam Hospital, Brown University School of; Medicine, Providence, Rhode Island 02906, USA.
Fever and renal failure in a 31-year-old male with AIDS [clinical conference]: Am J Med. 1997 Mar;102(3):310-5. Unique Identifier : AIDSLINE MED/97360642
Accuracy of oral specimen testing for human immunodeficiency virus.: Am J Med. 1997 Apr 1;102(4A):15-20. Unique Identifier : AIDSLINE MED/97360670; Emmons W; Division of Infectious Diseases, Naval Medical Center, Portsmouth,; Virginia, USA.; Antibodies to human immunodeficiency virus (HIV) can be detected in oral fluid with great accuracy, due to technical advances in both the collection of oral samples and assays. Reported sensitivities of 97.2-100% and specificities of 97.7-100% compare well with those of serum-based assays and qualify oral fluid for th
Epidemiology of acquired immunodeficiency syndrome: advancing to an endemic era.: Am J Med. 1997 Apr 1;102(4A):2-8. Unique Identifier : AIDSLINE MED/97360668; Graham NM; Department of Epidemiology, Johns Hopkins University, School of; Hygiene and Public Health, Baltimore, Maryland 21205, USA.; Acquired Immunodeficiency syndrome (AIDS) is now endemic in the United States . Human immunodeficiency virus (HIV) is the leading cause of death in U.S. adults aged 25-44 years. While the rate of infection among men who have sex with men has stabilized, that among women, minorities, and
Future applications of oral fluid specimen technology.: Am J Med. 1997 Apr 1;102(4A):21-5. Unique Identifier : AIDSLINE MED/97360671; George JR; Fitchen JH; Epitope, Inc., Beaverton, Oregon 97008-7108, USA.; Research has demonstrated that oral mucosal transudate (OMT), a serum-derived fluid that enters saliva from the gingival crevice and across oral mucosal surfaces, can be preferentially concentrated by a novel collecting system to yield detectable levels of immunoglobulins (i.e., IgG and IgM antibodies) against various
Virucidal activity of an oral fluid human immunodeficiency virus-1 antibody preservative.: Am J Med. 1997 Apr 1;102(4A):26-9. Unique Identifier : AIDSLINE MED/97360672; Bestwick RK; Fitchen JH; Epitope, Inc., Beaverton, Oregon 97008-7108, USA.; Diagnosis of human immunodeficiency virus-1 (HIV-1) infection requires the collection of either serum or oral fluid that is subsequently tested for the presence of antibodies to HIV-1. The effective use of oral fluid for the detection of HIV antibodies is contingent on stabilization of immunoglobulins in the sample th
Oral diagnostic testing for detecting human immunodeficiency virus-1 antibodies: a technology whose time has come.: Am J Med. 1997 Apr 1;102(4A):9-14. Unique Identifier : AIDSLINE MED/97360669; Malamud D; Department of Biochemistry, University of Pennsylvania, School of; Dental Medicine, Philadelphia 19104-6003, USA.; An oral fluid-based test for antibodies to human immunodeficiency virus (HIV), equivalent to serum in its accuracy but safer and easier to use, is now available in the United States . The development of the oral test involved overcoming technical obstacles to the use of oral fluid as a
Clinical significance of eosinophilia in HIV-infected individuals.: Am J Med. 1997 May;102(5):449-53. Unique Identifier : AIDSLINE MED/97360677; Skiest DJ; Keiser P; University of Texas Southwestern Medical Center, Dallas 75235-9113,; USA.; PURPOSE: To assess the clinical significance of peripheral eosinophilia in HIV-infected individuals. METHODS: In a retrospective case-control study we compared 42 HIV-infected patients (cases) with peripheral eosinophilia (absolute eosinophil count > 500 cells/mm3) with 84 HIV-infected controls without eosinophilia. C
Inflammatory myocardial diseases and cardiomyopathies.: Am J Med. 1997 May;102(5):459-69. Unique Identifier : AIDSLINE MED/97360679; Pisani B; Taylor DO; Mason JW; Department of Medicine, University of Utah Health Sciences Center,; Salt Lake City 84132, USA.; Inflammatory myocardial disease has been associated with a variety of infectious and noninfectious etiologies. It is associated with the development of dilated cardiomyopathy in some patients. Given its imprecise diagnosis, varied clinical presentation and undefined natural history, it is quite difficult to make broad
Intravenous lidocaine for treatment-resistant pruritus.: Am J Med. 1997 Jun;102(6):584-5. Unique Identifier : AIDSLINE MED/97360711; Fishman SM; Caneris OA; Stojanovic MP; Borsook D; Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Urbs in rure redux: changing risk factors for rural HIV infection.: Am J Med Sci. 1997 Jul;314(1):3-10. Unique Identifier : AIDSLINE MED/97359517; Roberts NE; Collmer JE; Wispelwey B; Farr BM; Department of Internal Medicine, University of Virginia Health; Sciences Center, Charlottesville 22908, USA.; The purpose was to ascertain risk factors for HIV infection in a predominantly rural population using descriptive epidemiologic studies performed at a university health sciences center. Participants included adult patients with HIV infection or AIDS who were cared for between January 1982 and January 1993. The relativ
Active replication of HIV-1 at the lymphoepithelial surface of the tonsil.: Am J Pathol. 1997 Jul;151(1):89-96. Unique Identifier : AIDSLINE MED/97356299; Frankel SS; Tenner-Racz K; Racz P; Wenig BM; Hansen CH; Heffner D; Nelson AM; Pope M; Steinman RM; Armed Forces Institute of Pathology, Walter Reed Army Institute of; Research, Rockville, Maryland, USA.; Cells that are infected with HIV-1 were visualized at the mucosal surface of the nasopharyngeal and palatine tonsils in 14 specimens from patients with CD4+ T-cell counts of 200 to 900/microliter and 2- to 10-year histories of HIV-1 infection. Most of the cells with intracellular HIV-1 protein were small but multinucl
Treatment of gastrointestinal cytomegalovirus infection with twice-daily foscarnet: a pilot study of safety, efficacy, and pharmacokinetics in patients with AIDS.: Antimicrob Agents Chemother. 1997 Jun;41(6):1226-30. Unique Identifier : AIDSLINE MED/97316901; Dieterich DT; Poles MA; Lew EA; Martin-Munley S; Johnson J; Nix D; Faust MJ; New York University Medical Center, New York, USA.; Ten patients with AIDS and cytomegalovirus ( CMV ) gastrointestinal infection were included in an open-label study to evaluate the safety, efficacy, and pharmacokinetics of 90 mg of intravenous foscarnet/kg of body weight twice
Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro.: Antimicrob Agents Chemother. 1997 Jun;41(6):1231-6. Unique Identifier : AIDSLINE MED/97316902; Hoggard PG; Kewn S; Barry MG; Khoo SH; Back DJ; Department of Pharmacology & Therapeutics, University of Liverpool,; United Kingdom.; Drugs commonly administered to patients infected with the human immunodeficiency virus (HIV) have been studied for their propensity to alter the intracellular phosphorylation of the anti-HIV nucleoside analog stavudine 2 ,3 -dideoxy-2 ,3 -didehydrothy
Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives.: Antimicrob Agents Chemother. 1997 Jun;41(6):1250-5. Unique Identifier : AIDSLINE MED/97316905; Baba M; Okamoto M; Makino M; Kimura Y; Ikeuchi T; Sakaguchi T; Okamoto T; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima; University, Sakuragaoka, Japan. baba@med3.kufm.kagoshima-u.ac.jp; We have found novel piperazinyloxoquinoline derivatives to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in both acutely and chronically infected cells. 8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-didehydro-7-[4-(2-met hoxyphenyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic ac
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine.: Antimicrob Agents Chemother. 1997 Jun;41(6):1313-8. Unique Identifier : AIDSLINE MED/97316916; Tanaka M; Srinivas RV; Ueno T; Kavlick MF; Hui FK; Fridland A; Driscoll JS; Mitsuya H; Experimental Retrovirology Section, Medicine Branch, Division of; Clinical Sciences, National Cancer Institute, Bethesda, Maryland; 20892, USA.; 2 -beta-Fluoro-2 ,3 -dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analog active against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains in vitro. F-ddA is presently undergoing a phase I clinical trial at the National Cancer Institute. We induced HIV-1 variants re
Spontaneous or interferon-gamma-induced T-cell infiltration, HLA-DR and ICAM-1 expression in genitoanal warts are associated with TH1 or mixed TH1/TH2 cytokine mRNA expression profiles.: Arch Dermatol Res. 1997 Apr;289(5):243-50. Unique Identifier : AIDSLINE MED/97307441; Grassegger A; Rollinger-Holzinger I; Zelger BW; Heim K; Zwierzina H; Fritsch PO; Hopfl RM; Department of Dermatology and Venereology, University of Innsbruck,; Austria.; The purpose of the study was to investigate the cytokine gene expression patterns and immunohistochemical characteristics of genitoanal warts in order to obtain a clue as to the immunological mechanisms possibly relevant for wart regression or persistence. We analysed surgically removed warts from 11 patients, 2 of wh
Dimensions of AIDS knowledge and risky sexual practices: a study of northern Thai males.: Arch Sex Behav. 1997 Jun;26(3):269-93. Unique Identifier : AIDSLINE MED/97292274; VanLandingham M; Grandjean N; Suprasert S; Sittitrai W; Sociology Department, University of Washington, Seattle 98195, USA.; The relation between AIDS-related knowledge and sexual risk-taking for a sample of young men living in northern Thailand was examined. Data were collected during the fall of 1991. The sample of 1472 men includes university students, soldiers, store clerks, and laborers. Recent co
Angioimmunoblastic lymphadenopathy-like T-cell lymphoma. A case report and immunologic study.: Auris Nasus Larynx. 1997 Apr;24(2):199-206. Unique Identifier : AIDSLINE MED/97279738; Kanzaki Y; Eura M; Chikamatsu K; Yoshida M; Masuyama K; Nishimura H; Ishikawa T; Department of Otolaryngology, Kumamoto University, School of Medicine,; Japan.; BACKGROUND: Angioimmunoblastic lymphadenopathy (AILD) is rare in the head and neck and its definition remains controversial. METHOD: A case of AILD with an ulcer of the lateral pharyngeal wall was studied for viral infection, immunohistologic findings and T-cell receptor (TCR) V beta rearrangement. RESULTS: We observe
Reassessing medical students' willingness to treat HIV-infected patients.: Acad Med. 1996 Nov;71(11):1250-2. Unique Identifier : AIDSLINE MED/97360552; Carter D; Lantos J; Hughes J; University of Chicago, Pritzker School of Medicine, Illinois, USA.; ddcarter@midway.uchicago.edu; BACKGROUND: Past research has demonstrated that some physicians do not feel obligated to care for patients infected with the human immunodeficiency virus (HIV). This study sought to characterize the attitudes that affect medical students willingness to treat HIV-infected patients and to determine which attitudes are
Global AIDS surveillance.: Wkly Epidemiol Rec. 1997 Jul 4;72(27):197-8. Unique Identifier : AIDSLINE MED/97367215
The current global situation of the HIV/AIDS pandemic.: Wkly Epidemiol Rec. 1997 Jul 4;72(27):199-200. Unique Identifier : AIDSLINE MED/97367216
HIV type 1 Tat protein enhances activation-but not Fas CD95)-induced peripheral blood T cell apoptosis in healthy individuals.: Int Immunol. 1997 Jun;9(6):835-41. Unique Identifier : AIDSLINE MED/97343410; Katsikis PD; Garcia-Ojeda ME; Torres-Roca JF; Greenwald DR; Herzenberg LA; Herzenberg LA; Department of Genetics, Stanford University School of Medicine, CA; 94305, USA.; T cell apoptosis may play an important role in the depletion and functional defects of T cells in HIV disease. A number of investigators have shown that peripheral blood T cells in HIV disease undergo spontaneous and activation-induced apoptosis. We found recently that peripheral blood T cells from HIV+ individuals un
CD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infection.: Int Immunol. 1997 Jun;9(6):843-51. Unique Identifier : AIDSLINE MED/97343411; Murayama Y; Amano A; Mukai R; Shibata H; Matsunaga S; Takahashi H; Yoshikawa Y; Hayami M; Noguchi A; Institute of Basic Medical Sciences, University of Tsukuba,; Ibaraki-ken, Japan.; We found that most peripheral CD4 cells co-express a low density of CD8 alpha antigen in African green monkeys (AGM). Further, the cell surface expression of CD4 and the expression of CD4 mRNA underwent a decrease when purified CD4CD8low cells were cultured with mitogen and
The molecular area characteristics of the HIV-1 gp41-fusion peptide at the air/water interface. Effect of pH.: Biochim Biophys Acta. 1997 Jun 12;1326(2):257-64. Unique Identifier : AIDSLINE MED/97361595; Taylor SE; Schwarz G; Department of Biophysical Chemistry, Biocenter of the University,; Basel, Switzerland.; The putative fusion peptide of HIV-1 is a highly surface active substance. Relevant measurements with the Langmuir monolayer technique have been carried out for a broad range of the pH in the aqueous subphase. The data are processed towards a quantitative analysis of the partitioning equilibrium between the interfacia
Virus neutralizing antibody titer to feline immunodeficiency virus isolates of subtypes A, B and D in experimentally or naturally infected cats.: J Vet Med Sci. 1997 May;59(5):377-81. Unique Identifier : AIDSLINE MED/97335693; Hohdatsu T; Fujimori S; Maeki M; Suma N; Motokawa K; Okada S; Koyama H; Department of Veterinary Infectious Diseases, School of Veterinary; Medicine and Animal Sciences, Kitasato University, Saitama, Japan.; Six strains of feline immunodeficiency virus (FIV) classified into subtypes A, B and D were examined by cross-neutralization test using Kumi-1 cells (CD4+, CD8+, and CD9+), an interleukin-2 dependent feline T-lymphocyte cell line. Neutralizing activities against these six FIV strains were also investigated in 50 FIV-a
Serum concentration of circulating immune complexes in cats infected with feline immunodeficiency virus detected by immune adherence hemagglutination method.: J Vet Med Sci. 1997 May;59(5):395-6. Unique Identifier : AIDSLINE MED/97335697; Matsumoto H; Takemura N; Sako T; Koyama H; Motoyoshi S; Inada Y; Department of Veterinary Internal Medicine, Nippon Veterinary and; Animal Science University, Tokyo, Japan.; Circulating immune complexes (CIC) in the sera from 45 clinically healthy cats and 23 feline immunodeficiency virus (FIV) infected cats were measured by an immune adherence hemagglutination (IAHA) method. The level of CIC in the sera from FIV sera-negative healthy cats was 47.2 +/- 47.3 micrograms/ml when expressed as
Abnormal expression of the B-cell homing chemokine receptor BLR1 during the progression of acquired immunodeficiency syndrome.: Blood. 1997 Jul 15;90(2):520-5. Unique Identifier : AIDSLINE MED/97369709; Forster R; Schweigard G; Johann S; Emrich T; Kremmer E; Nerl C; Lipp M; Max-Delbruck-Center for Molecular Medicine, Berlin-Buch, Germany.; The putative chemokine receptor BLR1 has been identified as the first G-protein-coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation
Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2.: Blood. 1997 Jul 15;90(2):745-53. Unique Identifier : AIDSLINE MED/97369734; Hashimoto F; Oyaizu N; Kalyanaraman VS; Pahwa S; Department of Pediatrics, North Shore University Hospital-New York; University School of Medicine, Manhasset 11030, USA.; We have previously demonstrated that CD4 cross-linking (CD4XL) results in apoptosis of CD4+ T cells and augmentation of Fas antigen (CD95, APO-1) expression in CD4+ and CD8+ T cells. Here we demonstrate that CD4XL mediated by both, anti-CD4 monoclonal antibody (MoAb) or human immunodeficiency virus (HIV) envelope prot
Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I.: Blood. 1997 Jul 15;90(2):783-94. Unique Identifier : AIDSLINE MED/97369738; Grossman WJ; Ratner L; Department of Medicine, Washington University School of Medicine, St; Louis, MO 63110, USA.; The human T-cell leukemia virus type I (HTLV-I) regulatory protein, Tax, has been speculated to play a major role in HTLV-I leukemogenesis. Indeed, several studies have suggested that upregulation of various cellular oncogenes and cytokines by Tax may explain the pathogenesis observed in HTLV-I-infected individuals, a
Downregulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy [letter; comment]: Blood. 1997 Jul 15;90(2):886-8. Unique Identifier : AIDSLINE MED/97369749; Bohler T; Herr I; Debatin KM; Geiss M; Haas J
Elevated serum level of Fas ligand correlates with the asymptomatic stage of human immunodeficiency virus infection [letter]: Blood. 1997 Jul 15;90(2):896-8. Unique Identifier : AIDSLINE MED/97369756; Bahr GM; Capron A; Dewulf J; Nagata S; Tanaka M; Bourez JM; Mouton Y
Allograft infiltrating cytotoxic T lymphocytes recognize kidney-specific human minor histocompatibility antigens.: Clin Transplant. 1997 Jun;11(3):174-7. Unique Identifier : AIDSLINE MED/97337096; Poindexter N; Shenoy S; Howard T; Flye MW; Mohanakumar T; Department of Surgery, Washington University, School of Medicine, St.; Louis, Missouri, USA.; The role of minor histocompatibility antigens (mH) in allograft immunity has been proposed, but the nature of these antigens and their immunogenicity are not well understood. We have shown that tissue-specific cytolytic T lymphocytes (CTL) can be isolated form graft infiltrating lymphocyte (GIL) populations from renal
Comment on Hall & Dolan's editorial on contact tracing [letter; comment]: Addiction. 1997 Mar;92(3):354. Unique Identifier : AIDSLINE MED/97362961; Dunn J
Correlation between CD29 density on CD8+ lymphocytes and serum IgG in systemic lupus erythematosus.: Lupus. 1997;6(4):379-84. Unique Identifier : AIDSLINE MED/97318040; Pallis M; Lim KL; Gardner-Medwin JM; Robins RA; Powell RJ; Department of Immunology, University Hospital, Nottingham, UK.; The purpose of this paper is to establish whether there is increased lymphocyte adhesion molecule density in systemic lupus erythematosus (SLE), which could alter the migration pathways and activation thresholds of lymphocytes and thus contribute to the pathogenesis of the disease. We analysed the CD11a, CD29 and CD2
New guidance on post exposure prophylaxis of health care workers exposed to HIV at work.: Commun Dis Rep CDR Wkly. 1997 Jul 4;7(27):239. Unique Identifier : AIDSLINE MED/97366976
Inmate access to postrelease medical care: public health implications [letter; comment]: Arch Fam Med. 1997 Jul-Aug;6(4):318. Unique Identifier : AIDSLINE MED/97369212; Macher AM; Goosby EP
Communication of preferences for care among human immunodeficiency virus-infected patients. Barriers to informed decisions?: Arch Fam Med. 1997 Jul-Aug;6(4):342-7. Unique Identifier : AIDSLINE MED/97369217; Mouton C; Teno JM; Mor V; Piette J; Department of Family Medicine, University of Medicine and; Dentistry-New Jersey Medical School, Newark, USA.; OBJECTIVE: To examine the way patients with serious, progressive illnesses communicate their care preferences to their physician. DESIGN: An observational, cross-sectional survey of 1031 clients with acquired immunodeficiency syndrome (AIDS) or symptomatic human immunodeficiency virus disease. Self-report of communica
Do physicians' own preferences for life-sustaining treatment influence their perceptions of patients' preferences? A second look.: Camb Q Healthc Ethics. 1997 Spring;6(2):131-7. Unique Identifier : AIDSLINE MED/97322917; Schneiderman LJ; Kaplan RM; Rosenberg E; Teetzel H; Department of Family and Preventive Medicine, School of Medicine,; University of California, San Diego, USA.
Lymphocytic subpopulation changes after open and laparoscopic cholecystectomy: a prospective and comparative study on 38 patients.: Surg Laparosc Endosc. 1997 Jun;7(3):255-61. Unique Identifier : AIDSLINE MED/97337551; Cristaldi M; Rovati M; Elli M; Gerlinzani S; Lesma A; Balzarotti L; Taschieri AM; Cattedra di Chirurgia Generale II, State University of Milan-Luigi; Sacco Hospital, Italy.; Up to now it has been unclear whether laparoscopic surgery has fewer immunosuppressive effects than traditional laparotomic procedures. In a series of 38 patients affected by symptomatic gallstone disease and operated on either by laparoscopy (group 1) or by traditional open surgery (group 2), we determined the postop
A model for making AIDS training accessible to health professionals in Puerto Rico.: Promot Educ. 1997 Mar;4(1):24-6. Unique Identifier : AIDSLINE MED/97318207; Bravo A; Gely DM; Puerto Rico AIDS Education and Training-Center (PRAETC); Universidad; de Puerto Rico; Recinto de Ciencias Medicas, San Juan 00936-5067, USA.
Odor hedonics: connection with emotional response estimated by autonomic parameters.: Chem Senses. 1997 Jun;22(3):237-48. Unique Identifier : AIDSLINE MED/97361242; Alaoui-Ismaili O; Vernet-Maury E; Dittmar A; Delhomme G; Chanel J; Laboratoire de Neurophysiologie, CNRS, Equipe Emotion-Cognition,; Universite Claude Bernard, Lyon, France.; The aim of this paper is to analyse the relationship between self-report hedonic evaluations and the physiological expression of emotion in response to odorants. We try to solve the following questions: (1) Is it possible to find any experimental evidence that the sense of smell is linked with emotion? (2) What kind o
Alterations in mucosal immune cell distribution in septic rats.: Shock. 1997 Mar;7(3):182-5. Unique Identifier : AIDSLINE MED/97220921; Osterberg J; Johnsson C; Gannedahl G; Westlund A; Haglund U; Department of Surgery, University Hospital, Uppsala, Sweden.; A reduced cell-mediated immunity in the intestinal mucosa might promote gut barrier failure and bacterial translocation in shock. This study was performed to investigate changes from the normal distribution of cellular components of the immune system within the intestine during sepsis. Intra-abdominal sepsis was induc
Psychopathology and psychotherapy in the dying AIDS patient.: Psychiatry Clin Neurosci. 1995 May;49 Suppl 1:S117-21. Unique Identifier : AIDSLINE MED/97323507; O'Dowd MA; Albert Einstein College of Medicine, Montefiore Medical Center, New; York 10467, USA.; AIDS is not yet the problem in Japan that it is in North American, Europe and Africa, but at the recent 10th International AIDS Conference held in Japan, it was estimated that more Asians will become infected with HIV in the coming year than any other population worldwide. Although
Lymphocyte subset changes between 3 and 15 months of age in infants born to HIV-seropositive women in South Africa.: Trop Med Int Health. 1997 May;2(5):415-21. Unique Identifier : AIDSLINE MED/97360732; Moodley D; Bobat RA; Coovadia HM; Doorasamy T; Munsamy S; Gouws E; Department of Paediatrics and Child Health, University of Natal,; Durban, South Africa.; The evolution of T-lymphocyte subsets during infancy in perinatally HIV-infected African babies has not been previously described. In a hospital-based cohort study, T-lymphocyte subset changes were investigated in 72 South African black children born to HIV seropositive mothers. Sixteen (22.2%; children were classifie
Who is really behind Clinton's AIDS vaccine crusade? [news]: Nat Med. 1997 Jul;3(7):711. Unique Identifier : AIDSLINE MED/97355607; Culliton BJ
What went right: why is HIV a treatable infection?: Nat Med. 1997 Jul;3(7):714-7. Unique Identifier : AIDSLINE MED/97355609; Wurtman RJ
Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning.: Nat Med. 1997 Jul;3(7):783-7. Unique Identifier : AIDSLINE MED/97355627; Sykes M; Szot GL; Swenson KA; Pearson DA; Transplantation Biology Research Center, Surgical Service,; Massachusetts General Hospital/Harvard Medical School, Boston 02129,; USA.; Donor-specific tolerance induced by bone marrow transplantation BMT) would allow organ allografting without chronic immunosuppressive therapy. However, the toxicity of conditioning regimens used to achieve marrow engraftment has precluded the clinical use of BMT for tolerance induction. We have developed a BMT strateg
[Perceptive deafness and AIDS]: Rev Neurol. 1997 Jun;25(142):887-90. Unique Identifier : AIDSLINE MED/97359024; Sancho EM; Dominguez L; Urpegui A; Martinez J; Jimenez M; Bretos S; Valles H; Servicio de ORL, Hospital Clinico Universitario de Zaragoza, Espana.; We report a case of a 23 years old woman HIV positive for the past five years with a four year history of right perceptive hypoacusia evolution without tinitus, vertigo or any other otologic symptomatology. After reviewing her personal and family history and conducting imilar tonal audiometry, tympanometry bilateral,
[Neuro-AIDS]: Rev Neurol. 1997 Jun;25(142):903-5. Unique Identifier : AIDSLINE MED/97359028; Tellechea N; da Silva CL; Colvero M; Schirmer M; Afonso-Galvao N; Servicio de Pediatria, Hospital de Clinicas de Porto Alegre,; Universidad Federal de Rio Grande Sul, Brasil.; The human immunodeficiency virus (HIV) type 1 is the retrovirus which is responsible for the human immunodeficiency syndrome AIDS) described in infancy in 1983. It is the most serious disorder caused by HIV, by a neurotropic virus, and is particularly severe in infancy. In children infected by vertical transmission of
[Viral encephalitis]: Rev Neurol. 1997 Jun;25(142):912-9. Unique Identifier : AIDSLINE MED/97359030; Arroyo HA; Bologna R; Servicio de Neurologia, Hospital Nacional de Pediatria J.P. Garrahan,; Buenos Aires, Argentina.; Viral infections of the nervous system make up a wide range of disorders with a mainly benign outcome. However, in some cases there is severe, morbimortality. In viral encephalitis there is direct involvement of the brain parenchyma which is seen clinically as reduced consciousness, convulsions and/or focal neurologic
A helix 1-extended hairpin ribozyme exhibits altered cleavage behavior in vitro.: Antisense Nucleic Acid Drug Dev. 1997 Apr;7(2):79-87. Unique Identifier : AIDSLINE MED/97293958; Moosbauer J; Tabler M; Institute of Molecular Biology and Biotechnology, Foundation for; Research and Technology-Hellas, Heraklion, Crete, Greece.; The catalytic domain of a hairpin ribozyme was incorporated at the 3 -end of a 254-base antisense RNA directed against the RNA of human immunodeficiency virus type 1 (HIV-1), generating a hairpin ribozyme with a largely extended helix 1. In parallel, a catalytic antisense RNA based on a hammerhead ribozyme was directe
Care for the patient with AIDS in the ICU: outcomes and ethics.: Clin Nurse Spec. 1997 Jan;11(1):31-8. Unique Identifier : AIDSLINE MED/97377444; Curtis JR; Marquis KA; Division of Pulmonary and Critical Care Medicine, University of; Washington, Seattle, USA.; HIV infection and AIDS are common diagnoses in many intensive care units (ICUs) in the United States . Although Pneumocystis carinii currently represents only one quarter of all diagnoses for which HIV-infected persons are admitted to the ICU, it is the disease with the most clinically
Alternative therapies and control for health in cancer and AIDS [see comments]: Clin Nurse Spec. 1997 Mar;11(2):64-9. Unique Identifier : AIDSLINE MED/97377451; Fryback PB; Reinert BR; Indiana University, USA.; People who are coping with AIDS and many forms of cancer have a sense of being out of control in dealing with their diseases. This stems, to a great degree, from the uncertainty that they feel relative to the accepted medical treatment for their disease. Informants in this naturalistic research study were adamant in t
Impact of HIV/AIDS on nurses & midwives focus of ICN statement [news]: Can Nurse. 1996 Jan;92(1):13. Unique Identifier : AIDSLINE MED/97077979
Assessment of neuronal density in the putamen in human immunodeficiency virus (HIV) infection. Application of stereology and spatial analysis of quadrats.: J Neurovirol. 1995 Mar;1(1):126-9. Unique Identifier : AIDSLINE MED/97365522; Everall I; Barnes H; Spargo E; Lantos P; Department of Neuropathology, Institute of Psychiotry, De Crespigny; Park, London, UK.; Human immunodeficiency virus causes neuronal loss in various brain regions, but it has not been reported in the putamen. However, decrease in the volume of the putamen has been observed by magnetic resonance imaging. In order to clarify this issue two complementary methods; the stereological probe, the disector, and s
Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy [see comments]: J Neurovirol. 1995 Mar;1(1):30-9. Unique Identifier : AIDSLINE MED/97365513; Saito Y; Sharer LR; Dewhurst S; Blumberg BM; Hall CB; Epstein LG; Department of Neurology, University of Rochester Medical Center, NY; 14642, USA.; Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien
Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells.: J Neurovirol. 1995 Mar;1(1):40-9. Unique Identifier : AIDSLINE MED/97365514; Atwood WJ; Wang L; Durham LC; Amemiya K; Traub RG; Major EO; Laboratory of Molecular Medicine and Neuroscience, National Institute; of Neurological Disorders and stroke, National Institutes of Health,; Bethesda, Maryland 20892, USA.; The human polyomavirus, JCV, is the etiologic agent of the fatal central nervous system demyelinating disease, progressive multifocal leukoencephalopathy. Progressive multifocal leukoencephalopathy occurs most frequently in patients with underlying immunosuppressive disorders and is the direct result of virus multipli
Progressive multifocal leukoencephalopathy: the evolution of a disease once considered rare.: J Neurovirol. 1995 Mar;1(1):5-18. Unique Identifier : AIDSLINE MED/97365511; Berger JR; Concha M; Department of Neurology, University of Miami School of Medicine,; Florida 33136, USA.; Progressive multifocal leukoencephalopathy, a formerly rare disease that chiefly occurred in persons with underlying lymphoma and chronic lymphocytic leukemia, is now seen with increasing frequency in the era of acquired immunodeficiency syndrome. Progressive multifocal leukoencephalopathy is currently estimated to ar
Characterization of a glial cell-specific DNA-protein complex formed with the human T cell lymphotropic virus type I (HTLV-I) enhancer.: J Neurovirol. 1995 Mar;1(1):62-77. Unique Identifier : AIDSLINE MED/97365516; Wessner R; Tillmann-Bogush M; Wigdahl B; Pennsylvania State University, College of Medicine, Department of; Microbiology and Immunology, Hershey 17033, USA.; Human T cell lymphotropic virus type I (HTLV-I) encodes the trans-activator, Tax, which facilitates viral transcription from three 21 bp repeated elements within the U3 region of the long terminal repeat (LTR). Electrophoretic mobility shift (EMS) analyses utilizing double-stranded (ds) oligonucleotides homologous to
Pathogenesis of lymphocyte-tropic and macrophage-tropic SIVmac infection in the brain.: J Neurovirol. 1995 Mar;1(1):78-91. Unique Identifier : AIDSLINE MED/97365517; Zhu GW; Liu ZQ; Joag SV; Pinson DM; Adany I; Narayan O; McClure HM; Stephens EB; Department of Microbiology, Molecular Genetics, and Immunology,; University of Kansas Medical Center, Kansas City 66160-7240, USA.; SIVmac239 replicates productivity in activated CD4+ T lymphocytes, but inefficiently in macrophages from rhesus macrophages. Inoculation of the virus into animals results in an acute, highly productive burst of virus replication in activated T lymphocytes in lymphoid tissues and infected cells invade the central nervo
Mutation of a major histocompatibility class I locus, H-2D, leads to an increased virus burden and disease susceptibility in Theiler's virus-induced demyelinating disease.: J Neurovirol. 1995 Jun;1(2):138-44. Unique Identifier : AIDSLINE MED/97365525; Lipton HL; Melvold R; Miller SD; Dal Canto MC; Division of Neurology, Evanston Hospital, Northwestern University,; Illinois 60201, USA.; Genetic studies have demonstrated that susceptibility to Theiler s murine encephalomyelitis virus (TMEV)-induced demyelinating disease is multigenic with linkage to the MHC class I locus, H-2D. We have analyzed the effect of mutations (H-2bm13 and H-2bm14) in the H-2Db gene on central nervous system (CNS) virus replic
Induction of HLA class II in HTLV-I infected neuronal cell lines.: J Neurovirol. 1995 Jun;1(2):145-56. Unique Identifier : AIDSLINE MED/97365526; Lehky TJ; Jacobson S; Neuroimmunology Branch, NIH, Bethesda, MD 20892, USA.; Human T-lymphotropic virus-I (HTLV-I) has been etiologically linked with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), a neurologic disease. The characteristic pathological finding in HAM/TSP is marked mononuclear infiltration of the CNS with destruction of the long tracts of the spinal cord. An
Capsid protein VP1 deletions in JC virus from two AIDS patients with progressive multifocal leukoencephalopathy.: J Neurovirol. 1995 Jun;1(2):189-94. Unique Identifier : AIDSLINE MED/97365530; Stoner GL; Ryschkewitsch CF; Laboratory of Experimental Neuropathology, National Institute of; Neurological Disorders and Stroke (NINDS), National Institutes of; Health, Bethesda, MD 20892, USA.; PCR on 52 cerebrospinal fluid (CSF) specimens and 33 brain biopsies obtained from HIV-1 positive patients utilized pairs of primers from both the early region (JTP) and late region (JLP). In these patients, in whom progressive multifocal leukoencephalopathy (PML) was suspected on the basis of clinical symptoms and mag
Human cytomegalovirus induces IL-6 and TNF alpha from macrophages and microglial cells: possible role in neurotoxicity.: J Neurovirol. 1995 Jun;1(2):219-27. Unique Identifier : AIDSLINE MED/97365533; Pulliam L; Moore D; West DC; Department of Laboratory Medicine, University of California, San; Francisco 94121, USA.; Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregate
The development of animal model systems for HIV-1 encephalitis and its associated dementia.: J Neurovirol. 1995 Sep;1(3-4):229-43. Unique Identifier : AIDSLINE MED/97365534; Persidsky Y; Nottet HS; Sasseville VG; Epstein LG; Gendelman HE; Department of Pathology and Microbiology, University of Nebraska; Medical Center, USA.; The human immunodeficiency virus (HIV) is neuroinvasive and can be neurovirulent. Indeed, 20-30% of individuals with the acquired immune deficiency syndrome (AIDS) develop cognitive and motor dysfunction (termed the AIDS dementia complex or HIV dementia) coincident with advanced im
Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis.: J Neurovirol. 1995 Sep;1(3-4):253-8. Unique Identifier : AIDSLINE MED/97365536; Liedtke W; Malessa R; Faustmann PM; Eis-Hubinger AM; Department of Neurology of Essen University Hospital, Germany.; A role for human herpesvirus 6 (HHV6) in the neurological complications associated with infection by human immunodeficiency virus (neuro-AIDS) and during multiple sclerosis (MS) is not known. For the present study, an improved PCR and immunofluorescence serology method were applied to sera and cerebrospinal fluid (CSF
Utility of cerebral proton magnetic resonance spectroscopy in differential diagnosis of HIV-related dementia.: J Neurovirol. 1995 Sep;1(3-4):268-74. Unique Identifier : AIDSLINE MED/97365538; Swindells S; McConnell JR; McComb RD; Gendelman HE; Department of Internal Medicine, University of Nebraska Medical; Center, Omaha, NE, USA.; Opportunistic infections often coexist with human immunodeficiency virus (HIV) infection in brain. Making the correct diagnosis is often difficult despite recent advances in neuroimaging techniques. 1H magnetic resonance spectroscopy (1H MRS) is an emerging non-invasive examination for diagnosis and monitoring of brai
Media components influence viral gene expression assays in human fetal astrocyte cultures.: J Neurovirol. 1995 Sep;1(3-4):275-85. Unique Identifier : AIDSLINE MED/97365539; McCarthy M; Wood C; Fedoseyeva L; Whittemore SR; Department of Neurology, University of Mian School of Medicine, FL; 33101, USA.; In vitro neurovirological studies of viral infectivity or viral gene expression may be confounded by the multiple neural cell types and/or fibroblast contamination present in early passage cultures prepared from dissociated human central nervous system CNS) tissue. We have developed highly enriched astrocyte cultures
Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions.: J Neurovirol. 1995 Sep;1(3-4):286-94. Unique Identifier : AIDSLINE MED/97365540; Saito M; Furukawa Y; Kubota R; Usuku K; Sonoda S; Izumo S; Osame M; Yoshida M; Department of Cellular and Molecular Biology, University of Tokyo,; Japan.; Human T-cell leukemia virus type 1 (HTLV-1) is an etiologic agent of adult T-cell leukemia (ATL) and of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Recently it has been reported that defective HTLV-1 provirus was detected frequently in the central nervous system (CNS) lesions of HAM/TSP patien
Quinolinic acid and neurodegeneration in AIDS [editorial; comment]: J Neurovirol. 1995 Dec;1(5-6):328-9. Unique Identifier : AIDSLINE MED/97365547; Wiley CA
Phenotypic and functional characterization of CD8+ T lymphocytes from the central nervous system of rats with coronavirus JHM induced demyelinating encephalomyelitis [see comments]: J Neurovirol. 1995 Dec;1(5-6):340-8. Unique Identifier : AIDSLINE MED/97365549; Hein A; Schwender S; Imrich H; Sopper S; Czub M; Dorries R; Institut fur Virologie und Immunbiologie, University of Wurzburg,; Germany.; Intracerebral infection of Lewis (LEW) inbred rats with the neurotropic strain of the murine coronavirus JHM (JHMV) frequently results in a monophasic paralytic disease. In contrast, infection of Brown Norway (BN) inbred rats does not lead to clinical disease. Previous findings ind
Quinolinic acid production is related to macrophage tropic isolates of HIV-1 [see comments]: J Neurovirol. 1995 Dec;1(5-6):369-74. Unique Identifier : AIDSLINE MED/97365552; Brew BJ; Corbeil J; Pemberton L; Evans L; Saito K; Penny R; Cooper DA; Heyes MP; Department of Neurology, St Vincent's Hospital, Sydney, Australia.; We sought to determine whether the neurotoxin quinolinic acid QUIN) was produced by macrophages or lymphocytes infected with isolates of HIV-1 with varying degrees of macrophage tropism derived from patients with varying stages of AIDS dementia complex (ADC). Highly macrophage trop
Neurocytotoxity of quinolinic acid in human brain cultures [see comments]: J Neurovirol. 1995 Dec;1(5-6):375-80. Unique Identifier : AIDSLINE MED/97365553; Kerr SJ; Armati PJ; Brew BJ; Department of HIV Medicine, St Vincent's Hospital, Darlinghurst, NSW,; Australia.; Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue
Molecular mimicry between HIV-1 gp41 and an astrocyte isoform of alpha-actinin.: J Neurovirol. 1995 Dec;1(5-6):381-90. Unique Identifier : AIDSLINE MED/97365554; Spehar T; Strand M; Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.; A 100-kDa astrocyte antigen previously shown to cross-react with a monoclonal antibody (MAb) generated against amino acids (aa) 598 to 609 of the transmembrane protein gp41 of human immunodeficiency virus type 1 [HIV-1] has now been molecularly characterized and found to be an alpha-actinin (alpha-actinin) related pro
Interaction of 68-kDa TAR RNA-binding protein and other cellular proteins with prion protein-RNA stem-loop.: J Neurovirol. 1995 Dec;1(5-6):391-8. Unique Identifier : AIDSLINE MED/97365555; Scheffer U; Okamoto T; Forrest JM; Rytik PG; Muller WE; Schroder HC; Institut fur Physiologische Chemie, Universitat, Mainz, Germany.; The RNA stem-loop structure of the trans-activating region TAR sequence of human immunodeficiency virus-1 mRNA is the binding site for a number of host cell proteins. A virtually identical set of proteins from HeLa nuclear extracts was found to bind to the predicted RNA hairpin element of prion protein (PrP) mRNA, as
Protective effects of interferon-gamma in intraocular herpes simplex type 1 infection do not depend on major histocompatibility complex class I or class II expression.: J Neurovirol. 1995 Dec;1(5-6):405-9. Unique Identifier : AIDSLINE MED/97365557; Geiger KD; Lee MS; Baugh C; Sarvetnick NE; Department of Neuropharmacology, Scripps Research Institute, La Jolla,; CA 92037, USA.; Intraocular infection with herpes simplex virus type I strain F HSV-1) induces bilateral retinitis, the expression of both MHC class I and II molecules and activation of CD4 and CD8 cells. To investigate the role of MHC upregulation in IFN-gamma mediated antiviral effects in intraocular infection with HSV-1, we infect
An oligopeptide of the feline leukemia virus envelope glycoprotein is associated with morphological changes and calcium dysregulation in neuronal growth cones.: J Neurovirol. 1997 Jun;3(3):179-91. Unique Identifier : AIDSLINE MED/97343509; Fails AD; Mitchell TW; Rojko JL; Whalen LR; Department of Anatomy and Neurobiology, Colorado State University,; Fort Collins 80523, USA.; Neuropathogenic processes that affect the pathfinding properties of neuronal growth cones could account for many of the dysfunctions unique to retroviral infection of developing nervous systems. Pediatric HIV-1 infection, for example, is associated with a distinctive neuropathogenesis that includes marked cortical atr
Search for herpesvirus DNA in cerebrospinal fluid of HIV patients with brain disorders: prevalence of cytomegalovirus DNA findings.: J Neurovirol. 1997 Jun;3(3):192-6. Unique Identifier : AIDSLINE MED/97343510; Portolani M; Meacci M; Sabbatini AM; Pietrosemoli P; Pecorari M; Cermelli C; De Rienzo B; Department of Biomedical Sciences, University of Modena, Italy.; A study was carried out to search for the presence of the seven human herpesvirus DNAs in cerebrospinal fluid from 52 human immunodeficiency virus-infected patients with brain disorders. Cytomegalovirus DNA was the most prevalent with 12 positive samples; Epstein-Barr virus and varicellazoster DNAs were detected in th
CD4+ and CD8+ T cells are not major effectors of mouse hepatitis virus A59-induced demyelinating disease.: J Neurovirol. 1997 Jun;3(3):225-8. Unique Identifier : AIDSLINE MED/97343514; Sutherland RM; Chua MM; Lavi E; Weiss SR; Paterson Y; Department of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6076, USA.; We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic
Primary cerebellar T-cell lymphoma with acquired immunodeficiency syndrome.: J Neurovirol. 1997 Jun;3(3):229-32. Unique Identifier : AIDSLINE MED/97343515; Embil JM; Halliday WC; Nath A; Department of Medicine, University of Manitoba, Winnipeg, Canada.; We report a 33-year-old man with the acquired immunodeficiency syndrome (AIDS) and a solitary T-cell lymphoma. Systemic sites of lymphomatous involvement could not be identified. Subtotal resection of the lesion with cranial irradiation resulted in a marked neurologic improvement. Our case suggests that T-cell lymphom
Stable neurological function in subjects treated with 2'3'-dideoxyinosine.: J Neurovirol. 1997 Jun;3(3):233-40. Unique Identifier : AIDSLINE MED/97343516; Sidtis JJ; Dafni U; Slasor P; Hall C; Price RW; Kieburtz K; Tucker T; Clifford DB; Department of Neurology, University of Minnesota, Minneapolis, USA.; AIDS Dementia Complex (ADC) is a frequent and devastating complication of HIV infection. There is evidence that zidovudine ZDV) has an effect in alleviating the symptoms of ADC, and may have a role in its prevention. It is therefore important that new antiretroviral therapies be evaluated not only for the risk of neur
Use of primary CNS cultures to investigate HIV neurotropism.: J Neurovirol. 1997 May;3 Suppl 1:S11-3. Unique Identifier : AIDSLINE MED/97323293; Gonzalez-Scarano F; Strizki JM; Albright A; Shieh J; Department of Neurology, University of Pennsylvania Medical Center,; Philadelphia 19104-6146, USA.
HIV neuropathogenesis.: J Neurovirol. 1997 May;3 Suppl 1:S14-5. Unique Identifier : AIDSLINE MED/97323294; Levy JA; University of California, San Francisco, USA.
The regulation of gene expression in neurotrophic viruses.: J Neurovirol. 1997 May;3 Suppl 1:S25-7. Unique Identifier : AIDSLINE MED/97323297; Roos RP; University of Chicago, Department of Neurology, Illinois 60637, USA.
Neuroglial ATF/CREB factors interact with the human immunodeficiency virus type 1 long terminal repeat.: J Neurovirol. 1997 May;3 Suppl 1:S28-32. Unique Identifier : AIDSLINE MED/97323298; Krebs FC; Goodenow MM; Wigdahl B; Pennsylvania State University, College of Medicine, Department of; Microbiology and Immunology, Hershey 17033, USA.
The role of CD4+ and CD8+ T cells in demyelinating disease following Theiler's virus infection: a model for multiple sclerosis.: J Neurovirol. 1997 May;3 Suppl 1:S43-5. Unique Identifier : AIDSLINE MED/97323302; Rodriguez M; Rivera-Quinones C; Murray PD; Kariuki Njenga M; Wettstein PJ; Mak T; Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901, USA.
Molecular epidemiology and emerging infectious diseases of the nervous system.: J Neurovirol. 1997 May;3 Suppl 1:S46-9. Unique Identifier : AIDSLINE MED/97323303; Weber T; Department of Neurology, Marienkrankenhaus Hamburg, Universitat; Hamburg, Germany.
Recent studies on the epidemiology, clinical features and pathogenic mechanisms of HTLV-I associated myelopathy (HAM/TSP) and other diseases associated to HTLV.: J Neurovirol. 1997 May;3 Suppl 1:S50-1. Unique Identifier : AIDSLINE MED/97323304; Osame M; Nakagawa M; Umehara F; Ijichi S; Moritoyo T; Higuchi I; Usuku K; Arimura K; Izumo S; Third Department of Internal Medicine, Faculty of Medicine, Kagoshima; University, Japan.
Alternative delivery systems for antiviral nucleosides and antisense oligonucleotides to the brain.: J Neurovirol. 1997 May;3 Suppl 1:S74-5. Unique Identifier : AIDSLINE MED/97323311; Levy RM; Ward S; Schalgeter K; Groothuis D; Department of Surgery (Neurosurgery), Northwestern University Medical; School, Chicago, Illinois 60611, USA.
Antitumor immune response of human peripheral blood lymphocytes coengrafted with tumor into severe combined immunodeficient mice.: Cancer Res. 1997 Jul 15;57(14):2937-42. Unique Identifier : AIDSLINE MED/97373722; Iwanuma Y; Chen FA; Egilmez NK; Takita H; Bankert RB; Department of Molecular Immunology, Roswell Park Cancer Institute, New; York State Department of Health, Buffalo 14263, USA.; Here, it is established that human peripheral blood lymphocytes HuPBLs), injected s.c. with a human lung tumor into severe combined immunodeficient (SCID) mice, engraft and display antitumor cytotoxic activity. Initial studies used HuPBLs from normal donors and an allogeneic tumor cell line derived from biopsy tissue
HIV and AIDS among the severely mentally ill: introduction to the special series.: Clin Psychol Rev. 1997;17(3):241-5. Unique Identifier : AIDSLINE MED/97303872; Carey MP; Cournos F; Department of Psychology, Syracuse University, NY 13244-2340, USA.; mpcarey@syr.edu; Men and women who have a severe and persistent mental illness are vulnerable to infection with HIV. Recognition of this vulnerability led the Office of AIDS at the National Institute of Mental Health (NIMH) to invite leading practitioners, researchers, consumer advocates, and policy makers to a National Conference on
Overview of severe mental illness.: Clin Psychol Rev. 1997;17(3):247-57. Unique Identifier : AIDSLINE MED/97303873; Johnson DL; Department of Psychology, University of Houston, TX 77204-5341, USA.; The severe mental illnesses are psychiatric disorders characterized by their persistence and extensive disability. Classification of these disorders has seen improved reliability, but problems remain with validity. Etiological formulations emphasize the biological origins of the disorders, but psychological factors, c
HIV seroprevalence among people with severe mental illness in the United States: a critical review.: Clin Psychol Rev. 1997;17(3):259-69. Unique Identifier : AIDSLINE MED/97303874; Cournos F; McKinnon K; College of Physicians and Surgeons, Columbia University, New York, NY,; USA.; The authors reviewed all studies in the peer-reviewed literature reporting HIV seroprevalence among people with severe mental illness in the United States , which varied from 4.0% to 22.9%. Findings across samples suggest that seroprevalence varies with geographic concentration of HIV a
Risk for human immunodeficiency virus (HIV) infection among persons with severe mental illnesses.: Clin Psychol Rev. 1997;17(3):271-91. Unique Identifier : AIDSLINE MED/97303875; Carey MP; Carey KB; Kalichman SC; Department of Psychology, Syracuse University, NY 13244-2340, USA.; mpcarey@syr.edu; Individuals diagnosed with a severe mental illness are at significantly enhanced risk for infection with the human immunodeficiency virus (HIV). To better understand elevated seroprevalence in this population, we review the research literature that has investigated HIV-related risk behavior among adults who have a sev
HIV risk reduction interventions for persons with severe mental illness.: Clin Psychol Rev. 1997;17(3):293-309. Unique Identifier : AIDSLINE MED/97303876; Kelly JA; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53202, USA.; Recent seroprevalence studies have shown alarming rates of HIV infection among severely mentally ill men and women in large urban areas, and HIV behavioral epidemiology research indicates that a substantial proportion of seriously mentally ill adults engage in activities that increase their vulnerability to HIV/AIDS.
Research on HIV, AIDS, and severe mental illness: recommendations from the NIMH National Conference.: Clin Psychol Rev. 1997;17(3):327-31. Unique Identifier : AIDSLINE MED/97303878; McKinnon K; Carey MP; Cournos F; New York State Psychiatric Institute, NY, USA.; We summarize the recommendations for research that emerged from a NIMH-sponsored Conference on HIV, AIDS, and Severe Mental Illness. Recommendations are made in four areas, namely, epidemiology of HIV infection, epidemiology of sexual and drug-use risk behaviors, risk reduction and transmission prevention, and treatme
Myocardial aspects of HIV infection [editorial]: Cardiologia. 1997 Apr;42(4):337-41. Unique Identifier : AIDSLINE MED/97331898; De Castro S; d'Amati G; Cartoni D; Fedele F
HIV sequence analysis used in court case [news]: Nat Biotechnol. 1997 May;15(5):397. Unique Identifier : AIDSLINE MED/97278293
FDA launches "new use initiative" [news]: Nat Biotechnol. 1997 May;15(5):399. Unique Identifier : AIDSLINE MED/97278297
Clearing the way for ribozymes [news]: Nat Biotechnol. 1997 May;15(5):414-5. Unique Identifier : AIDSLINE MED/97278306; Burke JM
Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice.: Cell. 1997 Jun 27;89(7):1011-9. Unique Identifier : AIDSLINE MED/97358528; Maraskovsky E; O'Reilly LA; Teepe M; Corcoran LM; Peschon JJ; Strasser A; Department of Cellular Immunology, Immunex Research and Development; Corporation, Seattle, Washington 98101, USA.; Signals from cytokine and antigen receptors play crucial roles during lymphocyte development. Mice lacking interleukin-7 receptor are lymphopenic, due to a defect in cell expansion at an early stage of differentiation, and the few mature T cells that develop in IL-7R-/- animals are functionally impaired. Both defects
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.: Cell. 1997 Jun 27;89(7):1087-99. Unique Identifier : AIDSLINE MED/97358535; Wang J; Sattar AK; Wang CC; Karam JD; Konigsberg WH; Steitz TA; Department of Molecular Biophysics and Biochemistry, Yale University,; New Haven, Connecticut 06520-8114, USA.; The 2.8 A resolution crystal structure of the bacteriophage RB69 gp43, a member of the eukaryotic pol alpha family of replicative DNA polymerases, shares some similarities with other polymerases but shows many differences. Although its palm domain has the same topology as other polymerases, except rat DNA polymerase b
[HIV infection and long-term health: therapeutically attainable?]: Z Arztl Fortbild Qualitatssich. 1997 Mar;91(2):149-53. Unique Identifier : AIDSLINE MED/97311897; Baumgarten R; II. Innere Abteilung/Infektion, Krankenhaus Prenzlauer Berg, Berlin.; New knowledges about the pathogenesis of HIV-induced immune deficiency syndrome suggest that a change of the natural history of HIV disease by support with antiviral medicaments will be possible. Most important insights are the non-existence of a viral latency phase and the existence of a strong correlation between ac
Communicable diseases surveillance.: Commun Dis Intell. 1997 Jun 26;21(13):178-87. Unique Identifier : AIDSLINE MED/97365323
Case management's role in human immunodeficiency virus care.: Nurs Case Manag. 1996 Nov-Dec;1(5):223-9. Unique Identifier : AIDSLINE MED/97349397; Highsmith C; Isaac Coggs Health Connection, Milwaukee, Wisconsin, USA.
Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats.: Clin Exp Immunol. 1997 Jul;109(1):134-42. Unique Identifier : AIDSLINE MED/97361875; Huang XR; Tipping PG; Apostolopoulos J; Oettinger C; D'Souza M; Milton G; Holdsworth SR; Monash University Centre for Inflammatory Diseases, Department of; Medicine, Monash Medical Centre, Clayton, Victoria, Australia.; The effector mechanisms of T cell-dependent acute glomerular injury were studied in autologous phase anti-GBM glomerulonephritis (GN) in rats. Acute proliferative GN was induced in sensitized rats by a subnephritogenic dose of sheep anti-rat GBM antibody. Injury was manifested by proteinuria and glomerular leucocyte i
Genetic differences in immune reactivity to mercuric chloride HgCl2): immunosuppression of H-2d mice is mediated by interferon-gamma (IFN-gamma).: Clin Exp Immunol. 1997 Jul;109(1):149-56. Unique Identifier : AIDSLINE MED/97361877; Doth M; Fricke M; Nicoletti F; Garotta G; Van Velthuysen ML; Bruijn JA; Gleichmann E; Division of Immunology, Medical Institute of Environmental Hygiene at; Heinrich Heine University Dusseldorf, Germany.; Upon treatment with HgCl2, H-2s mice, such as B10.S, develop an activation of B lymphocytes that depends, at least partially, on activation of T helper type 2 (Th2) cells and results in increased serum levels of IgG1 and IgE, appearance of IgG autoantibodies, and development of immune glomerulonephritis and vasculitis
Rescue by cytokines of apoptotic cell death induced by IL-2 deprivation of human antigen-specific T cell clones.: Clin Exp Immunol. 1997 Jul;109(1):185-93. Unique Identifier : AIDSLINE MED/97361882; Kaneko S; Suzuki N; Koizumi H; Yamamoto S; Sakane T; Department of Immunology, St. Marianna University School of Medicine,; Kawasaki, Kanagawa, Japan.; The control of cell survival and cell death is of central importance in tissues with high cell turnover such as the lymphoid system. We have examined the effect of cytokines on IL-2 deprivation-induced apoptosis of human antigen-specific T helper clones with different
Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype.: Clin Exp Immunol. 1997 Jul;109(1):4-11. Unique Identifier : AIDSLINE MED/97361856; Gattorno M; Facchetti P; Ghiotto F; Vignola S; Buoncompagni A; Prigione I; Picco P; Pistoia V; II Division of Pediatrics, G. Gaslini Institute for Children, Genova,; Italy.; The aim of the present study was to investigate the patterns of cytokine production by T cell clones raised from in vivo activated synovial fluid (SF) mononuclear cells (MNC) of five patients with oligoarticular juvenile arthritis (JA). Freshly isolated SF T cells were cultured in vitro with low dose recombinant
Role of tumour necrosis factor-alpha (TNF-alpha) in the induction of HIV-1 gp120-mediated CD4+ T cell anergy.: Clin Exp Immunol. 1997 Jul;109(1):41-6. Unique Identifier : AIDSLINE MED/97361861; Kaneko H; Hishikawa T; Sekigawa I; Hashimoto H; Okumura K; Kaneko Y; Department of Internal Medicine and Rheumatology, Juntendo University; School of Medicine, Tokyo, Japan.; The HIV-1 envelope glycoprotein (gp 120) is known to induce antigen-specific and non-specific CD4+ T cell anergy. We found that early T cell activation, as indicated by HLA-DP expression in the early G1 (G1A) phase of the cell cycle, and the inhibition of mitogen-mediated
Quantification of IgA and IgG and specificities of antibodies to viral proteins in parotid saliva at different stages of HIV-1 infection.: Clin Exp Immunol. 1997 Jul;109(1):47-53. Unique Identifier : AIDSLINE MED/97361862; Cartry O; Moja P; Quesnel A; Pozzetto B; Lucht FR; Genin C; Groupe Immunite des Muqueuses et Agents Pathogenes, University of; Saint-Etienne, France.; Paired sera and parotid saliva from 75 HIV-1-infected patients, divided in three equal groups with CD4+ cell counts > 500, 200-500 and
Elevated plasma levels of IgE in Plasmodium falciparum-primed individuals reflect an increased ratio of IL-4 to interferon-gamma (IFN-gamma)-producing cells.: Clin Exp Immunol. 1997 Jul;109(1):84-9. Unique Identifier : AIDSLINE MED/97361868; Elghazali G; Perlmann H; Rutta AS; Perlmann P; Troye-Blomberg M; Department of Immunology, Stockholm University, Sweden.; People living in Plasmodium falciparum-endemic areas frequently have elevated levels of total as well as P. falciparum-specific serum IgE. This study aimed at investigating whether the elevated serum IgE levels reflect a shift in the balance between CD4+ T helper 1 (Th1) and T helper 2 (Th2) cells in individuals natur
IL-5 expressed by CD4+ lymphocytes from Echinococcus multilocularis-infected patients.: Clin Exp Immunol. 1997 Jul;109(1):90-7. Unique Identifier : AIDSLINE MED/97361869; Jenne L; Kilwinski J; Scheffold W; Kern P; Section of Infectious Diseases and Clinical Immunology, University; Hospital and Medical Clinic of Ulm, Germany.; IL-5 is a major factor inducing differentiation of B lymphocytes into immunoglobulin-producing cells as well as a main regulator of eosinophils. Recently, we have shown that peripheral blood mononuclear cells (PBMC) from patients with alveolar echinococcosis (AE) express IL-5 mRNA after stimulation with crude Echinoco
Retroviral infection in peripheral mononuclear cells in patients with IgA nephropathy.: Clin Nephrol. 1997 Apr;47(4):211-6. Unique Identifier : AIDSLINE MED/97274781; Kanno Y; Suzuki H; Okada H; Nakazato Y; Saruta T; Department of Internal Medicine, School of Medicine, Keio University,; Tokyo, Japan.; An etiologic agent directly linked to the development of IgA nephropathy (IgAN) has not been identified, despite the fact that various causes, including viral infections, have been implicated in the pathogenesis of this disease. Human immunodeficiency virus HIV) infection has been linked with the development of IgAN i
TI-201 chloride and Tc-99m ECD brain SPECT in lymphoma with and without massive necrosis.: Clin Nucl Med. 1997 Jun;22(6):427-30. Unique Identifier : AIDSLINE MED/97337087; Shih WJ; McCormick MI; Wilson D; Nuclear Medicine Service, VA Medical Center, University Kentucky; Medical Center, Lexington 40511, USA.
Pyogenic arthritis caused by streptococcus equisimilis (group-C streptococcus) in a patient with AIDS.: Clin Rheumatol. 1997 May;16(3):314-6. Unique Identifier : AIDSLINE MED/97327605; Steinfeld S; Galle C; Struelens M; De Gheldre Y; Farber CM; Appelboom T; Van Vooren JP; Dept of Rheumatology, Erasmus Hospital, Free University of Brussels,; Belgium.; A patient with the Acquired ImmunoDeficiency Syndrome (AIDS) treated with a daily low dose of corticosteroids for chronic atopic dermatitis experienced a sudden episode of unilateral knee arthritis. Culture of the purulent synovial liquid yielded a pure culture of Streptococcus Equisimilis. A four week period of intra
Salmonella osteomyelitis in a patient with human immunodeficiency virus infection [letter]: Clin Rheumatol. 1997 May;16(3):319-20. Unique Identifier : AIDSLINE MED/97327607; Belzunegui J; Lopez L; Arrizabalaga J; Gonzalez C; Figueroa M
Peripheral blood lymphocyte binding to a soluble FITC-fibronectin conjugate.: Cytometry. 1997 Jun 1;28(2):157-64. Unique Identifier : AIDSLINE MED/97325253; Pallis M; Robins RA; Powell RJ; Department of Immunology, University Hospital, Nottingham, United; Kingdom.; Fibronectin receptors are critical to lymphocyte-mediated inflammation, and binding between immobilised plasma fibronectin and peripheral blood lymphocytes (pbl) is enhanced in patients with inflammatory diseases. Such enhancement could be due to an overall increase in receptor capacity and/or be a feature of a subset
[HIV: adjusting therapy to viral burden (news)]: Dtsch Med Wochenschr. 1997 Jun 20;122(25-26):A21. Unique Identifier : AIDSLINE MED/97365428
[Protease inhibitors--a class of substances ready to take off editorial)]: Dtsch Med Wochenschr. 1997 Jun 20;122(25-26):805-7. Unique Identifier : AIDSLINE MED/97365419; Keysser G; Burmester GR
The N-terminal Arg-rich region of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef is involved in RNA binding.: Eur J Biochem. 1997 May 15;246(1):38-44. Unique Identifier : AIDSLINE MED/97354169; Echarri A; Gonzalez ME; Carrasco L; Centro de Biologia Molecular CSIC-UAM, Universidad Autonoma de Madrid,; Spain.; Comparison of the amino acid sequences of human immunodeficiency virus (HIV) Nef protein and several RNA-binding proteins shows similarities in some regions of these proteins. Thus, poliovirus protein 2C, an RNA-binding protein, shares with Nef the sequence YXQQ...MDD...DXXD. In addition, both proteins contain an Arg-
FIGO News. Report of the FIGO Committee for the Study of Ethical Aspects of Human Reproduction. International Federation of Gynecologists and Obstetrics [news]: Int J Gynaecol Obstet. 1997 Jun;57(3):333-7. Unique Identifier : AIDSLINE MED/97358382; Schenker JG; Hadassah Hospital Jerusalem.
Specific cytotoxicity against cells bearing HIV1 gp120 antigen by bacteriophage-encapsidated ricin A chain: implications for cell specific drug delivery.: Biochem Soc Trans. 1997 May;25(2):158S. Unique Identifier : AIDSLINE MED/97334535; Wu M; Brown WL; Hill HR; Stockley PG; Department of Biology, University of Leeds, UK.
Workers exposed to respiratory hazards show altered expression of cell surface markers.: Biochem Soc Trans. 1997 May;25(2):198S. Unique Identifier : AIDSLINE MED/97334575; Curran AD; Allan LJ; Gordon SB; Wiley K; Health and Safety Laboratory, Sheffield, United Kingdom.
Dysfunctional focal adhesion kinase (pp125FAK) expression in HIV-infected donor T-cells.: Biochem Soc Trans. 1997 May;25(2):219S. Unique Identifier : AIDSLINE MED/97334596; Ng TT; Kanner SB; Humphries MJ; Wickremasinghe RG; Nye KE; Anderson J; Morrow WJ; Department of Immunology, St Bartholomew's, UK.
A recombinant HIV gag p17 protein suppresses the function of normal T cells.: Biochem Soc Trans. 1997 May;25(2):220S. Unique Identifier : AIDSLINE MED/97334597; Eugen-Olsen J; Koppelhus U; Andresen L; Nielsen JO; Hofmann B; University of Copenhagen, Hvidovre Hospital, Dept. of Infectious; Diseases, Denmark.
Interactions with T cells induce expression of VCAM-1 by human intrahepatic endothelial cells in vitro.: Biochem Soc Trans. 1997 May;25(2):255S. Unique Identifier : AIDSLINE MED/97334632; Arvieux C; McNab G; Adams DH; Liver Research Laboratories, Queen Elizabeth Hospital, Edgbaston,; Birmingham.
Cultured human intrahepatic endothelial cells stimulate alloproliferative responses in highly purified CD4 and CD8+ T cells in vitro.: Biochem Soc Trans. 1997 May;25(2):256S. Unique Identifier : AIDSLINE MED/97334633; Arvieux C; McNab G; Hathaway M; Adams DH; Department of Medicine, Queen Elizabeth Hospital, Birmingham.
Cellular immune response to foot-and-mouth disease virus.: Biochem Soc Trans. 1997 May;25(2):275S. Unique Identifier : AIDSLINE MED/97334652; Cedillo-Barron L; Childrestone A; Cook A; Foster-Cuevas M; Parkhouse RM; Escuela Nacional de Ciencias Biologicas, I.P.N. Mexico, D.F.
Theileria annulata "superantigen" activity--TCB usage by responding bovine CD4+ cells from uninfected donors.: Biochem Soc Trans. 1997 May;25(2):277S. Unique Identifier : AIDSLINE MED/97334654; Campbell JD; Russell GC; Nelson RE; Spooner RL; Glass EJ; Centre for Topical Veterinary Medicine, University of Edinburgh,; Roslin. Midlothian, U.K.
Early immune events following experimental infection of lambs with Mycobacterium avium subspecies paratuberculosis.: Biochem Soc Trans. 1997 May;25(2):279S. Unique Identifier : AIDSLINE MED/97334656; Begara-McGorum IM; Wildblood LA; Jones DG; Moredun Research Institute, Edinburgh.
In-situ localisation of immunocompetent cells in Fasciola hepatica infestation in rats and mice.: Biochem Soc Trans. 1997 May;25(2):280S. Unique Identifier : AIDSLINE MED/97334657; Whelan HE; Fadiel MM; Joyce P; Kelly JL; Dept. Biological Science, Dublin Institute of Technology, Ireland.
Comparison of peripheral blood phenotype in pathogenic and attenuated SIV infection.: Biochem Soc Trans. 1997 May;25(2):284S. Unique Identifier : AIDSLINE MED/97334661; Lines JL; Walker KB; Almond NM; Stott EJ; Stebbings RJ; National Institute for Biological Standards and Control, Potters Bar,; Herts, U.K.
Cytokine profiling of simian immunodeficiency virus infection of cynomologus macaques. Pathogenic SIVmac251 pJ5C versus non-pathogenic attenuated SIVmac251 pC8C reveals divergence.: Biochem Soc Trans. 1997 May;25(2):285S. Unique Identifier : AIDSLINE MED/97334662; Stabbings RJ; Lines JL; Almond NM; Stott EJ; Walker KB; National Institute of Biological Standards and Control, Potters Bar,; Hertfordshire, U.K.
Enhancement of immunogenicity of recombinant antigens by production of a cytokine-antigen fusion protein for vaccination.: Biochem Soc Trans. 1997 May;25(2):297S. Unique Identifier : AIDSLINE MED/97334674; McCormick AL; Thomas MS; Heath AW; Dept. Medical Microbiology, University of Sheffield Medical School,; United Kingdom.
T-cell subsets in autoimmune haemolytic anaemia.: Biochem Soc Trans. 1997 May;25(2):312S. Unique Identifier : AIDSLINE MED/97334689; Barker RN; Shen CR; Mazza G; Perry FE; Hall AM; Elson CJ; Department of Medicine & Therapeutics, University of Aberdeen,; Foresterhill, U.K.
Mechanisms of immunity to the respiratory pathogen Bordetella pertussis in normal and gene knockout mice: clearance of primary infection is not enhanced by therapeutic interleukin-12.: Biochem Soc Trans. 1997 May;25(2):341S. Unique Identifier : AIDSLINE MED/97334719; Mahon BP; Ryan M; Griffin F; Mills KH; Department of Biology, National University of Ireland at Maynooth, Co.; Kildare, Ireland.
Regulation of the activity of the transcription factors AP-1 and NFAT during differentiation of precursor CD4+ T-cells into effector cells.: Biochem Soc Trans. 1997 May;25(2):347-54. Unique Identifier : AIDSLINE MED/97334448; Rincon M; Flavell RA; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06520-8011, USA.
Cytokine secretion by human T cell clones is differentially regulated by eicosanoids.: Biochem Soc Trans. 1997 May;25(2):347S. Unique Identifier : AIDSLINE MED/97334725; Harbige LS; Layward L; Morris MM; Amor S; Department of Immunology, Rayne Institute, UMDS, St Thomas' Hospital,; London, UK.
Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses.: Biochem Soc Trans. 1997 May;25(2):359-60. Unique Identifier : AIDSLINE MED/97334450; Grusby MJ; Harvard School of Public Health, Department of Cancer Biology, Boston,; MA 02115, USA.
Selective migration of the human helper/inducer T-cell subset CD4+) in BCG-induced arthritis.: Biochem Soc Trans. 1997 May;25(2):371S. Unique Identifier : AIDSLINE MED/97334749; Farahat MN; Dept. of Medicine, El-Hussein University Hospital, Al-Azhar; University, El-Darrasa, Cairo, Egypt.
Use of peptides to selectively modulate CD4+ T-cell responses.: Biochem Soc Trans. 1997 May;25(2):398-403. Unique Identifier : AIDSLINE MED/97334458; Hetzel C; Janssen R; Ely S; Young D; Lamb JR; Thole J; Department of Biology, Imperial College of Science, Technology and; Medicine, London, U.K.
Regulation of apoptosis through CD95 (APO-I/Fas) receptor-ligand interaction.: Biochem Soc Trans. 1997 May;25(2):405-10. Unique Identifier : AIDSLINE MED/97334459; Debatin KM; Beltinger C; Bohler T; Fellenberg J; Friesen C; Fulda S; Herr I; Los M; Scheuerpflug C; Sieverts H; Stahnke K; University Children's Hospital, Heidelberg, Germany.
Immune deviation towards Th2 inhibits Th-1-mediated autoimmune diabetes.: Biochem Soc Trans. 1997 May;25(2):625-9. Unique Identifier : AIDSLINE MED/97334502; Adorini L; Trembleau S; Roche Milano Ricerche, Italy.
Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model.: Biochem Soc Trans. 1997 May;25(2):630-5. Unique Identifier : AIDSLINE MED/97334503; von Herrath MG; Homann D; Gairin JE; Oldstone MB; Department of Neuropharmacology, Scripps Research Institute, La Jolla,; CA 92037, USA.
Role of natural killer and NK1+ T-cells in regulating cell-mediated immunity during Toxoplasma gondii infection.: Biochem Soc Trans. 1997 May;25(2):699-703. Unique Identifier : AIDSLINE MED/97334519; Denkers EY; Sher A; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
Ten-year experience with endomyocardial biopsy in myocarditis presenting with congestive heart failure: frequency, pathologic characteristics, treatment and follow-up.: G Ital Cardiol. 1997 Mar;27(3):209-23. Unique Identifier : AIDSLINE MED/97343360; Arbustini E; Gavazzi A; Dal Bello B; Morbini P; Campana C; Diegoli M; Grasso M; Fasani R; Banchieri N; Porcu E; Pilotto A; Ponzetta M; Bellini O; Lucreziotti S; Vigano M; Pathologic Anatomy Institute, Pavia.; The present study summarizes our ten-year (1985-1995) experience with endomyocardial biopsy (EMB) in patients with idiopathic congestive heart failure (CHF), with specific reference to frequency of myocarditis, treatment policy, relative benefits, and follow-up. Of the 601 patients who constituted our series, 38 were
[Perforation of cytomegalovirus appendicitis in a patient with human immunodeficiency virus infection (letter)]: Gastroenterol Clin Biol. 1997;21(4):346-7. Unique Identifier : AIDSLINE MED/97351726; Mazza D; Fabiani P; Gigante M; Boissy C; Michiels JF; Mouiel J
[Determination of the genotoxicity of fullerene C60 and fullerol using the method of somatic mosaics on cells of Drosophila melanogaster wing and SOS-chromotest]: Genetika. 1997 Mar;33(3):405-9. Unique Identifier : AIDSLINE MED/97275362; Zakharenko LP; Zakharov IK; Vasiunina EA; Karamysheva TV; Danilenko AM; Nikiforov AA; Genotoxicity of fullerene C60 was been determined in a prokaryotic in vitro test and in an eukaryotic in vivo system. The SOS chromotest of fullerene C60 in the Escherichia coli strain PQ37 revealed no genotoxicity either with or without activation of the rat liver homogenate. To perform the somatic mutation and recom
Effect of lamivudine on morphology and function of mitochondria in patients with chronic hepatitis B.: Hepatology. 1997 Jul;26(1):211-5. Unique Identifier : AIDSLINE MED/97357121; Honkoop P; de Man RA; Scholte HR; Zondervan PE; Van Den Berg JW; Rademakers LH; Schalm SW; Department of Internal Medicine II, Erasmus University Hospital,; Rotterdam, The Netherlands.; Nucleoside analogues can induce mitochondrial dysfunction leading to severe clinical syndromes. Lamivudine , a new nucleoside analogue, is an active inhibitor of hepatitis B viral replication without apparent clinical toxicity. To assess subclinical mi
Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro [see comments]: Hepatology. 1997 Jul;26(1):216-25. Unique Identifier : AIDSLINE MED/97357122; Colledge D; Locarnini S; Shaw T; Victorian Infectious Diseases Reference Laboratories, Fairfield; Hospital, Victoria, Australia.; Lamivudine ([-]-beta-L-2 ,3 -dideoxy-3 -thiacytidine [ 3TC ]) and penciclovir (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine [PCV]) are potent inhibitors of hepatitis B virus (HBV)
Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa.: Hepatology. 1997 Jul;26(1):226-31. Unique Identifier : AIDSLINE MED/97357123; Lam NP; Neumann AU; Gretch DR; Wiley TE; Perelson AS; Layden TJ; Department of Pharmacy Practice, College of Pharmacy, University of; Illinois at Chicago, 60612, USA.; To determine if the clearance of hepatitis C genotype 1 virus HCV) is dependent on the dose of interferon alfa-2b IFN-alpha2b), the acute clearance of HCV after a single dose of either 3, 5, or 10 mIU of IFN-alpha was compared in patients with chronic hepatitis C. HCV-RNA levels following IFN-alpha administration were
Combination therapy for chronic hepatitis B [editorial; comment]: Hepatology. 1997 Jul;26(1):234-7. Unique Identifier : AIDSLINE MED/97357125; Fontana RJ; Lok AS
Adoptive transfer of allergen-specific CD4+ T cells induces airway inflammation and hyperresponsiveness in brown-Norway rats.: Immunology. 1997 Jun;91(2):176-85. Unique Identifier : AIDSLINE MED/97371089; Haczku A; Macary P; Huang TJ; Tsukagoshi H; Barnes PJ; Kay AB; Kemeny DM; Chung KF; Moqbel R; Department of Allergy and Clinical Immunology, Guy's Hospital, London,; UK.; Following allergen exposure, sensitized Brown- Norway rats develop airway hyperresponsiveness (AHR) and eosinophilic inflammation together with an increase in activated T cells (CD25+) in the airways. We tested the hypothesis that CD4+ T cells are involved directly in the acquisitio
Cytotoxic T-lymphocyte interaction with fibronectin and vitronectin: activated adhesion and cosignalling.: Immunology. 1997 Jun;91(2):186-92. Unique Identifier : AIDSLINE MED/97371090; Ybarrondo B; O'Rourke AM; McCarthy JB; Mescher MF; Division of Membrane Biology, Medical Biology Institute, La Jolla, CA,; USA.; Stimulation of cloned cytotoxic T lymphocytes (CTL) with anti-T-cell receptor (TCR) monoclonal antibody (mAb) in solution resulted in rapid and sustained activation of adhesion to immobilized fibronectin (FN) but did not initiate degranulation. Addition of a second antibody (Ab) to further cross-link the TCR substanti
Heterogeneity of cytokine functions in HIV infection.: Immunology. 1997 Jun;91(2):234-8. Unique Identifier : AIDSLINE MED/97371097; Kundu SK; Merigan TC; Center for AIDS Research, Division of Infectious Diseases and; Geographic Medicine, Stanford University Medical Center, CA, USA.; Immunological responses, especially cytokines, play important roles in determining the persistence of infectious agents in chronic diseases. Th1 responses enhance cellular immunity to control infection whereas Th2 immune responses down-regulate these effector immune responses. It has been suggested that the Th1 to Th2
Polyclonal Th1 cells transfer oil-induced arthritis.: Immunology. 1997 Jun;91(2):260-5. Unique Identifier : AIDSLINE MED/97371101; Svelander L; Mussener A; Erlandsson-Harris H; Kleinau S; Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden.; T-cells play a critical role in oil-induced arthritis (OIA) in DA rats. The present study focuses on the involvement of CD4/CD8 T cells in OIA by using adoptive transfer. Mitogen-activated T cells from DA rats previously injected with incomplete Freund s adjuvant (IFA) were depleted of CD4+ T cells or CD8+ T cells bef
In situ T-cell responses in a primary regressive melanoma and subsequent metastases: a comparative analysis.: Int J Cancer. 1997 Jul 17;72(2):241-7. Unique Identifier : AIDSLINE MED/97363534; Carcelain G; Rouas-Freiss N; Zorn E; Chung-Scott V; Viel S; Faure F; Bosq J; Hercend T; Unite INSERM U267, Hopital Paul Brousse, Villejuif, France.; In an earlier study of the immune response in a patient with a cutaneous primary regressive melanoma, a T-cell-receptor diversity analysis demonstrated in situ amplification of certain lymphocytes. Two of them could be cloned and characterized as CD8+ HLA-class-l-restricted CTL with strong selective anti-tumor activit
[HIV-related aspects in research and therapy]: Internist (Berl). 1995 Jun;36(6 Suppl):1-12. Unique Identifier : AIDSLINE MED/97361160
Whole-life insurance is being offered to some persons infected with HIV [editorial]: J Am Osteopath Assoc. 1997 May;97(5):261, 301. Unique Identifier : AIDSLINE MED/97339230
Semicochliodinol A and B: inhibitors of HIV-1 protease and EGF-R protein tyrosine kinase related to asterriquinones produced by the fungus Chrysosporium merdarium.: J Antibiot (Tokyo). 1997 May;50(5):395-401. Unique Identifier : AIDSLINE MED/97351627; Fredenhagen A; Petersen F; Tintelnot-Blomley M; Rosel J; Mett H; Hug P; Core Drug Discovery Technologies, Ciba-Geigy Ltd., Basel, Switzerland.; The known bisalkylated 2,5-dihydroxybenzoquinones didemethylasterriquinone D and isocochliodinol as well as the new metabolites semicochliodinol A and B have been isolated as inhibitors of HIV-1 protease from the culture broth of the fungus Chrysosporium merdarium P-5656. The structures were elucidated by spectroscopi
Prophylaxis against CMV infection in transplant patients.: J Antimicrob Chemother. 1997 Mar;39(3):299-301. Unique Identifier : AIDSLINE MED/97250321; Griffiths PD; Department of Virology, Royal Free Hospital School of Medicine,; London, UK.
A simple method for measurement of cell-substrate attachment forces: application to HIV-1 Tat.: J Cell Sci. 1997 Jan;110 ( Pt 2):249-56. Unique Identifier : AIDSLINE MED/97196966; Channavajjala LS; Eidsath A; Saxinger WC; Laboratory of Tumor Cell Biology, NIH/National Cancer Institute,; Bethesda, MD, USA.; In order to understand the importance of cell attachment to HIV-1 Tat, we quantified the strength of cell attachment to immobilized Tat in microtiter plate wells by the application of buoyant force. By replacing the attachment medium with dense medium, and subjecting the attached cells in the microtiter plates to cent
On needles, breasts and bullets: health and the conflict of values.: J Clin Pharm Ther. 1996 Dec;21(6):363-6. Unique Identifier : AIDSLINE MED/97345194; Kilwein JH; School of Pharmacy, University of Pittsburgh, PA 15261, USA.
Importance of method in the determination of syncytium-inducing phenotype of human immunodeficiency virus type 1 clinical isolates.: J Virol Methods. 1997 Mar;64(2):137-45. Unique Identifier : AIDSLINE MED/97234486; Liesnard C; Delforge ML; Tchetcheroff M; De Maertelaer V; Farber CM; Van Vooren JP; Laboratoire de Reference SIDA, Hopital Erasme, Brussels, Belgium.; The in vitro syncytium induction capacity of human immunodeficiency virus type 1 (HIV1) isolates is an important marker in the progression of the disease. Two methods have been widely used to determine the biological phenotype of HIV1. These two methods, the direct MT-2 assay and the supernatant assay, were compared f
Study of internal transcribed spacer and mitochondrial large-subunit genes of Pneumocystis carinii hominis isolated by repeated bronchoalveolar lavage from human immunodeficiency virus-infected patients during one or several episodes of pneumonia.: J Clin Microbiol. 1997 Jul;35(7):1687-90. Unique Identifier : AIDSLINE MED/97339575; Latouche S; Poirot JL; Bernard C; Roux P; Laboratoire de Parasitologie-Mycologie, CHU Saint-Antoine, Paris,; France.; The objective of this study was to type, analyze, and compare Pneumocystis carinii hominis strains obtained from different samples during a given or recurrent episodes of P. carinii pneumonia (PCP) for epidemiologic purposes. We studied 36 bronchoalveolar lavage (BAL) or induced sputum (IS) samples from 16 human immun
Simplified sample processing combined with a sensitive one-tube nested PCR assay for detection of Pneumocystis carinii in respiratory specimens.: J Clin Microbiol. 1997 Jul;35(7):1691-5. Unique Identifier : AIDSLINE MED/97339576; Mathis A; Weber R; Kuster H; Speich R; Institute of Parasitology, University of Zurich, Switzerland.; Early diagnosis of Pneumocystis carinii pneumonia, a life-threatening complication in immunosuppressed patients, may lower morbidity and mortality. We have developed a one-tube nested PCR assay for the detection of P. carinii in respiratory specimens. Four primers were selected from the sequence of the small-subunit r
Variations in fluconazole susceptibility and DNA subtyping of multiple Candida albicans colonies from patients with AIDS and oral candidiasis suffering one or more episodes of infection.: J Clin Microbiol. 1997 Jul;35(7):1761-5. Unique Identifier : AIDSLINE MED/97339589; Redding SW; Pfaller MA; Messer SA; Smith JA; Prows J; Bradley LL; Fothergill AW; Rinaldi MG; Department of General Dentistry, University of Texas Health Science; Center, San Antonio 78284, USA.; Five Candida albicans colonies from each infection in AIDS patients receiving fluconazole therapy for oropharyngeal candidiasis over a 2-year period were evaluated by antifungal susceptibility testing and DNA subtyping, and the results were correlated with clinical response to determine the occurrence of clinically si
Identification of Enterocytozoon bieneusi spores in respiratory samples from an AIDS patient with a 2-year history of intestinal microsporidiosis.: J Clin Microbiol. 1997 Jul;35(7):1862-6. Unique Identifier : AIDSLINE MED/97339611; del Aguila C; Lopez-Velez R; Fenoy S; Turrientes C; Cobo J; Navajas R; Visvesvara GS; Croppo GP; Da Silva AJ; Pieniazek NJ; Departamento de Biologia, Facultad de Ciencias Experimentales y; Tecnicas, Universidad San Pablo CEU, Madrid, Spain.; Enterocytozoon bieneusi, a microsporidian parasite, has been recognized since 1985 as an agent of intestinal microsporidiosis leading to malabsorption syndrome, diarrhea, and weight loss in AIDS patients. Recently, however, we have identified E. bieneusi spores in the
Emergence of rifampin-resistant Rhodococcus equi in an infected foal.: J Clin Microbiol. 1997 Jul;35(7):1904-8. Unique Identifier : AIDSLINE MED/97339624; Takai S; Takeda K; Nakano Y; Karasawa T; Furugoori J; Sasaki Y; Tsubaki S; Higuchi T; Anzai T; Wada R; Kamada M; Department of Animal Hygiene, School of Veterinary Medicine and Animal; Sciences, Kitasato University, Towada, Aomori, Japan.; takai@vmas.kitasato-u.ac.jp; To investigate the emergence of rifampin resistance in Rhodococcus equi strains isolated from foals and their environment in Japan , we compared the in vitro antimicrobial susceptibilities to rifampin of 640 isolates from 64 infected foals and 98 soil isolates from their horse-breedi
Susceptibilities to co-trimoxazole of pathogens isolated from blood and stool specimens in Abidjan, Ivory Coast, 1994 to 1996 [letter]: J Clin Microbiol. 1997 Jul;35(7):1915. Unique Identifier : AIDSLINE MED/97339626; Anglaret X; Sylla-Koko F; Bonard D; Combe P; Coulibaly M; Aoussi E; Dabis F
Stability and performance of a population pharmacokinetic model.: J Clin Pharmacol. 1997 Jun;37(6):486-95. Unique Identifier : AIDSLINE MED/97352073; Ette EI; Office of Clinical Pharmacology & Biopharmaceutics, Food and Drug; Administration, Rockville, Maryland 20857, USA.; This study aimed to determine the stability (in terms of covariate selection) of a population pharmacokinetic model and evaluate its performance in the absence of a test data set. Data from 88 full-term infants, 11 of whom were human immunodeficiency virus (HIV)-seropositive, taking an antiinfective agent were analyze
Granulomatous-ulcerative vulvar cryptococcosis in a patient with advanced HIV disease.: J Am Acad Dermatol. 1997 Jul;37(1):116-7. Unique Identifier : AIDSLINE MED/97359618; Tomasini C; Caliendo V; Puiatti P; Bernengo MG; Department of Dermatology, University of Turin, Italy.
Papular mucinosis associated with AIDS: response to isotretinoin.: J Am Acad Dermatol. 1997 Jul;37(1):127-8. Unique Identifier : AIDSLINE MED/97359623; Yen A; Sanchez RL; Raimer SS; Department of Dermatology, University of Texas Medical Branch at; Galveston, USA.
Confidentiality and the acquired immune deficiency syndrome AIDS): an analysis of the legal and professional issues.: J Adv Nurs. 1997 Jun;25(6):1162-6. Unique Identifier : AIDSLINE MED/97325359; Hayter M; Department of Community and Primary Care Nursing, University of; Sheffield, England.; Confidentiality is one of the most significant concepts in health care and nursing practice, particularly in the arena of HIV infection and AIDS. The implications for individuals of deliberate or accidental disclosure of their HIV status can and does have far reaching effects. This paper will explore the concept of co
An investigation into whether nursing student alter their attitudes and knowledge levels regarding HIV infection and AIDS following a 3-year programme leading to registration as a qualified nurse.: J Adv Nurs. 1997 Jun;25(6):1167-74. Unique Identifier : AIDSLINE MED/97325360; Snowden L; Canterbury Christ Church College, England.; The purpose of this study was to examine whether a 3-year programme of nursing studies enabled nursing students to graduate from the course with greater knowledge and more positive attitudes towards HIV infection and AIDS than when they began the course. Students on a maths and information technology course were used
Patient rights, provider rights: balancing the conflict [see comments]: J Am Dent Assoc. 1997 Jul;128(7):1029-33. Unique Identifier : AIDSLINE MED/97375281; Sfikas PM; Loyola University of Chicago School of Law, USA.
Pathogenetic role of phagocytic abnormalities in human virus immunodeficiency infection: possible therapeutical approaches. A review.: Immunopharmacol Immunotoxicol. 1997 May;19(2):147-64. Unique Identifier : AIDSLINE MED/97276249; Covelli V; Pece S; Giuliani G; De Simone C; Jirillo E; II Faculty of Medicine, University of Napoli, Italy.; Polymorphonuclear cells (PMN) and monocytes/macrophages (M/M) represent the first defence line against invading microorganisms. Both phagocytic cell functions are precociously compromised in human immunodeficiency virus (HIV)-infected subjects, thus leading to infectious and neurological complications in the late stag
Nosocomial transmission of human immunodeficiency virus and subsequent transmission of multidrug-resistant tuberculosis in a healthcare worker.: Infect Control Hosp Epidemiol. 1997 Jun;18(6):422-3. Unique Identifier : AIDSLINE MED/97325346; Ridzon R; Kenyon T; Luskin-Hawk R; Schultz C; Valway S; Onorato IM; Division of Tuberculosis Elimination, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; A phlebotomist with nosocomially acquired human immunodeficiency virus infection developed tuberculosis 10 months after exposure to multidrug-resistant Mycobacterium tuberculosis during a nosocomial outbreak. Healthcare workers with immunosuppression are at increased risk of tuberculosis if infected and, if exposed, s
Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response.: J Immunol. 1997 Jul 15;159(2):1004-11. Unique Identifier : AIDSLINE MED/97361662; Sun B; Rizzo LV; Sun SH; Chan CC; Wiggert B; Wilder RL; Caspi RR; Laboratory of Immunology, National Eye Institute, National Institutes; of Health, Bethesda, MD 20892, USA.; This study examines whether genetic susceptibility vs resistance to experimental autoimmune uveoretinitis (EAU) in mice is associated with dominant type 1 vs type 2 cytokine response profiles. Mice from six strains were immunized with the uveitogenic retinal Ag IRBP. EAU was evaluated by histopathology. As judged by d
Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes.: J Immunol. 1997 Jul 15;159(2):574-81. Unique Identifier : AIDSLINE MED/97361610; Garcia-Maurino S; Gonzalez-Haba MG; Calvo JR; Rafii-El-Idrissi M; Sanchez-Margalet V; Goberna R; Guerrero JM; Department of Medical Biochemistry and Molecular Biology, The; University of Seville School of Medicine and Virgen Macarena Hospital,; Spain.; This paper shows that melatonin is able to activate human Th1 lymphocytes by increasing the production of IL-2 and IFN-gamma in vitro. Th2 cells appear not to be affected by melatonin, since IL-4, which is mostly produced by Th2 cells, is not modified by the hormone. M
The role of protein kinase C in CD8+ T lymphocyte effector responses.: J Immunol. 1997 Jul 15;159(2):582-90. Unique Identifier : AIDSLINE MED/97361611; Nesic D; Jhaver KG; Vukmanovic S; Department of Pathology, and Kaplan Comprehensive Cancer Center, New; York University Medical Center, New York 10016, USA.; Rare CD8+ T cells present in beta2microglobulin-deficient beta2m-/-) mice reject allogeneic tumors but not syngeneic wild-type tumors. The lack of syngeneic tumor rejection in vivo is correlated with a partial response of beta2m-/- CD8+ cell lines to syngeneic tumor cells in vitro. This partial response is characteriz
Cytokine-deficient CD8+ Tc1 cells induced by IL-4: retained inflammation and perforin and Fas cytotoxicity but compromised long term killing of tumor cells.: J Immunol. 1997 Jul 15;159(2):606-13. Unique Identifier : AIDSLINE MED/97361614; Sad S; Li L; Mosmann TR; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada. Subash.Sad@nrc.ca; After antigenic stimulation, naive CD8+ T cells differentiate into cytotoxic Tc1 cells secreting the cytokines IL-2 , IFN-gamma, and TNF, which aid their proliferation and effector functions. We have previously shown that IL-4 acts directly on differentiated Tc1 cells t
Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumor.: J Immunol. 1997 Jul 15;159(2):650-63. Unique Identifier : AIDSLINE MED/97361619; Kedl RM; Mescher MF; The Center for Immunology and the Department of Laboratory Medicine; and Pathology, University of Minnesota, Minneapolis 55455, USA.; The response of CD8+ T cells to allogeneic tumor was studied by adoptive transfer of cells from TCR transgenic 2C mice specific for Ld alloantigen. Transferred cells were monitored during the course of a response to i.p. challenge with live P815 (H-2d) using the 1B2 mAb specific for the 2C TCR. Tumor was present in th
Increased lymphocyte apoptosis in Fas ligand transgenic mice.: J Immunol. 1997 Jul 15;159(2):674-84. Unique Identifier : AIDSLINE MED/97361621; Cheng J; Liu C; Yang P; Zhou T; Mountz JD; Department of Medicine, University of Alabama at Birmingham, and; Veterans Administration Medical Center, AL 35294, USA.; Fas ligand (fasL) transgenic (Tg) mice were produced by introducing a murine fasL cDNA under the control of a TCR beta-chain enhancer minigene. Higher levels of fasL expression with increased biologic activity were observed in the Tg mice compared with non-Tg mice. Numbers of CD4+ CD8+ T cells in the thymus and T cell
Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene.: J Immunol. 1997 Jul 15;159(2):685-93. Unique Identifier : AIDSLINE MED/97361622; van Ginkel FW; McGhee JR; Liu C; Simecka JW; Yamamoto M; Frizzell RA; Sorscher EJ; Kiyono H; Pascual DW; Department of Microbiology and The Cystic Fibrosis Research Center,; University of Alabama at Birmingham, 35294, USA.; Replication-deficient adenovirus (Ad) vectors are effective to specifically target the respiratory epithelium for either corrective gene therapy such as cystic fibrosis or for mucosal immunization. As a consequence of transducing the lower respiratory tract with an E1/E3 deleted Ad5 vector, host responses have been ch
IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis.: J Immunol. 1997 Jul 15;159(2):777-85. Unique Identifier : AIDSLINE MED/97361634; Brunet LR; Finkelman FD; Cheever AW; Kopf MA; Pearce EJ; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, NY 14853, USA.; To examine the role of the Th2-type response during schistosomiasis mansoni we compared disease progression in wild type (wt), and Th2-response deficient IL-4(-/-) mice. Whereas wt C57BL/6 mice tolerate infection and develop chronic disease, IL-4(-/-) C57BL/6 animals are highly susceptible, exhibiting severe acute cac
Pulmonary microsporidiosis due to Encephalitozoon hellem in a patient with AIDS.: J Infect. 1997 Mar;34(2):119-26. Unique Identifier : AIDSLINE MED/97284058; Scaglia M; Sacchi L; Croppo GP; da Silva A; Gatti S; Corona S; Orani A; Bernuzzi AM; Pieniazek NJ; Slemenda SB; Wallace S; Visvesvara GS; Laboratory of Clinical Parasitology, University-IRCCS S. Matteo,; Pavia, Italy.; The microsporidian Encephalitozoon hellem is being reported with increasing frequency in HIV-positive subjects, as an agent of disseminated microsporidiosis without involving the gastrointestinal tract. We describe a case of pulmonary microsporidiosis in a 27-year-old
Alopecia areata heralding cytomegalovirus reactivation in AIDS [letter]: J Infect. 1997 Mar;34(2):159-60. Unique Identifier : AIDSLINE MED/97284070; Piras MA; Aceti A
Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia.: J Leukoc Biol. 1997 Jul;62(1):100-6. Unique Identifier : AIDSLINE MED/97369512; Persidsky Y; Gendelman HE; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68198-5215, USA.; The neuropathogenesis of HIV-1 encephalitis and its associated dementia revolves around sustained viral replication in cells of mononuclear phagocyte origin (brain macrophages, multinucleated giant cells, and microglia). Macrophage secretory factors play important roles in facilita
Cellular aspects of HIV-1 infection of macrophages leading to neuronal dysfunction in in vitro models for HIV-1 encephalitis.: J Leukoc Biol. 1997 Jul;62(1):107-16. Unique Identifier : AIDSLINE MED/97369513; Nottet HS; Bar DR; van Hassel H; Verhoef J; Boven LA; Eijkman-Winkler Institute, Section Neuroviroimmunology, Utrecht, The; Netherlands.; HIV-1 is a hematogenously spread virus that most likely gains entry into the brain within blood-derived macrophages. Indeed, productive viral replication selectively occurs within perivascular and parenchymal blood-derived macrophages and microglia and HIV-infected macrophages have increased potential to bind and tran
HIV infection of macrophages and pathogenesis of AIDS dementia complex: interaction of the host cell and viral genotype.: J Leukoc Biol. 1997 Jul;62(1):117-25. Unique Identifier : AIDSLINE MED/97369514; Cunningham AL; Naif H; Saksena N; Lynch G; Chang J; Li S; Jozwiak R; Alali M; Wang B; Fear W; Sloane A; Pemberton L; Brew B; Centre for Virus Research, Westmead Institutes of Health Research,; Westmead Hospital, NSW, Sydney, Australia.; AIDS dementia complex (ADC) develops in only a third of HIV-infected patients who progress to AIDS. Macrophages and microglial cells are the major cellular sites of productive HIV replication in brain. Using 11 blood isolates of HIV from asymptomatic patients there was marked varia
Significance of macrophage tropism of SIV in the macaque model of HIV disease.: J Leukoc Biol. 1997 Jul;62(1):12-9. Unique Identifier : AIDSLINE MED/97369499; Stephens EB; Galbreath D; Liu ZQ; Sahni M; Li Z; Lamb-Wharton R; Foresman L; Joag SV; Narayan O; Department of Microbiology, Molecular Genetics and Immunology, Marion; Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas; Medical Center, Kansas City 66160-7317, USA.; Microglia, alveolar macrophages, and Langerhans cells are representatives of cells of macrophage lineage that are susceptible to infection with HIV-1 and they play important roles in the pathogenesis of AIDS dementia , lymphoid interstitial pneumonia, and systemic viral invasion fro
IL-13 acts on macrophages to block the completion of reverse transcription, inhibit virus production, and reduce virus infectivity.: J Leukoc Biol. 1997 Jul;62(1):126-32. Unique Identifier : AIDSLINE MED/97369515; Montaner LJ; Bailer RT; Gordon S; Wistar Institute, Philadelphia, Pennsylvania 19104, USA.; An understanding of the immune suppression of HIV-1 replication in macrophages continues to be a major goal of AIDS research due to the central role this cell type has in AIDS pathogenesis. We have previously discussed the potential clinical benefits of the anti-inflammatory cytokine interleukin-13 (IL-13), which, unl
Targeting antiviral nucleotide analogues to macrophages.: J Leukoc Biol. 1997 Jul;62(1):133-7. Unique Identifier : AIDSLINE MED/97369516; Magnani M; Rossi L; Fraternale A; Casabianca A; Brandi G; Benatti U; De Flora A; Institute of Biochemistry Giorgio Fornaini, University of Urbino,; Italy.; Macrophages are important target cells for human immunodeficiency virus type 1 (HIV-1) infection. We have developed a drug targeting system for the selective delivery of phosphorylated nucleoside analogues to these phagocytosing cells. This system is based on the possibility of encapsulating the phosphorylated drugs i
Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes.: J Leukoc Biol. 1997 Jul;62(1):138-43. Unique Identifier : AIDSLINE MED/97369517; Aquaro S; Perno CF; Balestra E; Balzarini J; Cenci A; Francesconi M; Panti S; Serra F; Villani N; Calio R; Department of Experimental Medicine and Biochemical Sciences,; University of Rome Tor Vergata, Italy.; Several anti-HIV drugs acting on different steps of virus replication were tested in our experimental model of primary monocyte/macrophages; the results were compared with the activity found in lymphocytes. Nucleoside analogues ( AZT , ddI,
MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression.: J Leukoc Biol. 1997 Jul;62(1):30-3. Unique Identifier : AIDSLINE MED/97369501; Sozzani S; Introna M; Bernasconi S; Polentarutti N; Cinque P; Poli G; Sica A; Mantovani A; Department of Immunology and Cell Biology, Istituto di Ricerche; Farmacologiche Mario Negri, Milan, Italy.; Monocyte chemotactic protein-1 (MCP-1) interacts with the chemokine receptor CCR2. Two CCR2 cDNAs have been described. Sequence analysis as well as Northern blotting and RNase protection with different probes revealed that the CCR2 gene is expressed in activated natural killer (NK) cells and mononuclear phagocytes as
Role of pro-inflammatory cytokines and beta-chemokines in controlling HIV replication.: J Leukoc Biol. 1997 Jul;62(1):34-40. Unique Identifier : AIDSLINE MED/97369502; Vicenzi E; Biswas P; Mengozzi M; Poli G; AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific; Institute, Milan, Italy.; Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines wi
Macrophage tropism: fact or fiction?: J Leukoc Biol. 1997 Jul;62(1):4-11. Unique Identifier : AIDSLINE MED/97369498; Stent G; Joo GB; Kierulf P; Asjo B; Department of Microbiology and Immunology, Gade Institute, University; of Bergen, Norway.; Primary HIV-1 isolates can be distinguished by phenotypic qualities such as the ability to productively infect cells of established CD4-positive lines and to induce syncytia in MT-2 cells. Such viral phenotypes have also been reported to confer host cell specificity. It is perceived that primary isolates with the sync
GM-CSF and its effects on replication of HIV-1 in cells of macrophage lineage.: J Leukoc Biol. 1997 Jul;62(1):41-8. Unique Identifier : AIDSLINE MED/97369503; Crowe SM; Lopez A; Macfarlane Burnet Centre for Medical Research, Victoria, South; Australia, Australia.; Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoetic growth factor that is a member of the four-helix bundle family of cytokines and growth factors. It regulates the proliferation and differentiation of granulocytes and cells of macrophage lineage from bone marrow progenitor cells, mediating these
Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation.: J Leukoc Biol. 1997 Jul;62(1):49-53. Unique Identifier : AIDSLINE MED/97369504; Gessani S; Borghi P; Fantuzzi L; Varano B; Conti L; Puddu P; Belardelli F; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.; We previously reported that in vitro culture of human peripheral blood monocytes resulted in a time-dependent differentiation into macrophages and in an enhanced capacity for producing certain cytokines [i.e., tumor necrosis factor alpha, interleukin-6 IL-6), and interferon-beta (IFN-beta)] in response to bacterial li
Intracellular GSH content and HIV replication in human macrophages.: J Leukoc Biol. 1997 Jul;62(1):54-9. Unique Identifier : AIDSLINE MED/97369505; Garaci E; Palamara AT; Ciriolo MR; D'Agostini C; del-Latif MS; Aquaro S; Lafavia E; Rotilio G; Department of Experimental Medicine, University of Rome, Tor Vergata,; Italy.; In vitro HIV-1 infection induced a significant decrease in intracellular reduced glutathione (GSH) in human macrophages. Such a decrease was observed at the time of infection corresponding to maximum release of virus from infected cells and was not related to cell cytotoxicity. GSH los was not related to its oxidation
Possible participation of polymorphonuclear cells stimulated by microbial immunomodulators in the dysregulated cytokine patterns of AIDS patients.: J Leukoc Biol. 1997 Jul;62(1):60-6. Unique Identifier : AIDSLINE MED/97369506; Cassone A; Chiani P; Quinti I; Torosantucci A; Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di; Sanita, Rome, Italy.; Macrophages and polymorphonuclear cells (PMN) play a major role as cells primarily responsive to microbial biological response modifiers (BRM). Although much attention has been given to macrophages, PMN have been relatively underinvestigated. We have recently studied the responses of PMN from HIV- and HIV+ subjects af
Immune stimulation and HIV-1 viral replication.: J Leukoc Biol. 1997 Jul;62(1):67-71. Unique Identifier : AIDSLINE MED/97369507; Wahl SM; Orenstein JM; Oral Infection and Immunity Branch, National Institute of Dental; Research, National Institutes of Health, Bethesda, Maryland; 20892-4352, USA.; A biphasic early and late viremia is characteristic of HIV-1 infection. The first increase in circulating viral burden occurs within weeks after infection, before a host immune response, and the second, later peak emerges during the inevitable HIV-1 devastation of immune function. Recently, intermittent bouts of virem
Infection of gastrointestinal tract macrophages by HIV-1.: J Leukoc Biol. 1997 Jul;62(1):72-7. Unique Identifier : AIDSLINE MED/97369508; Smith PD; Meng G; Shaw GM; Li L; Department of Medicine, University of Alabama School of Medicine,; Birmingham 35294, USA.; As the largest lymphoid organ and the largest reservoir of macrophages in the body, the gastrointestinal tract mucosa is probably the largest organ reservoir of macrophages infected with HIV-1. To elucidate the biology of HIV-1 infection of intestinal macrophages, we isolated lamina propria macrophages from normal hum
Mechanisms of loss of functional dendritic cells in HIV-1 infection.: J Leukoc Biol. 1997 Jul;62(1):78-81. Unique Identifier : AIDSLINE MED/97369509; Knight SC; Elsley W; Wang H; Antigen Presentation Research Group, Imperial College School of; Medicine at Northwick Park Institute for Medical Research, Harrow,; United Kingdom.; Dendritic cells (DC) are lost from blood and skin during injection with HIV-1; those remaining show a reduced capacity to stimulate T cell proliferation [S. C. Knight, AIDS 10, 807-817]. Our recent studies investigate mechanisms underlying these effects. DC exposed to HIV-1 vitro can act as targets for cytotoxic T cel
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.: J Leukoc Biol. 1997 Jul;62(1):82-92. Unique Identifier : AIDSLINE MED/97369510; Hiscott J; Beauparlant P; Crepieux P; DeLuca C; Kwon H; Lin R; Petropoulos L; Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical; Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal,; Quebec, Canada.; NF-kappa B/Rel transcription factors participate in the activation of numerous genes involved in immune regulation/inflammation including cytokines, cell surface receptors, adhesion molecules, and acute phase proteins. NF-kappa B activity is controlled by inhibitory proteins, I kappa Bs, that maintain the DNA-binding
HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitro.: J Leukoc Biol. 1997 Jul;62(1):93-9. Unique Identifier : AIDSLINE MED/97369511; Ayyavoo V; Mahalingam S; Rafaeli Y; Kudchodkar S; Chang D; Nagashunmugam T; Williams WV; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia, USA.; Among the putative accessory genes of HIV-1, the 96-amino-acid virion-associated vpr gene product has been described to have several novel biological activities. These include cytoplasmic-to-nuclear translocation, which empowers HIV to infect and replicate in non-dividing cells and to increase viral replication, parti
Upregulation of Fas ligand by simian immunodeficiency virus - a nef-arious mechanism of immune evasion?: J Exp Med. 1997 Jul 7;186(1):1-5. Unique Identifier : AIDSLINE MED/97351114; Johnson RP; Division of Immunology, New England Regional Primate Research Center,; Harvard Medical School, Southborough, Massachusetts 01772, USA.
A role for CD4 in peripheral T cell differentiation.: J Exp Med. 1997 Jul 7;186(1):101-7. Unique Identifier : AIDSLINE MED/97351125; Brown DR; Moskowitz NH; Killeen N; Reiner SL; Department of Medicine, Committee on Immunology and Gwen Knapp Center; for Lupus and Immunology Research, University of Chicago, Chicago,; Illinois 60637, USA.; Naive CD4+ T helper cells (Th) differentiate into one of two well-defined cell types during immune responses. Mature Th1 and Th2 cells regulate the type of response as a consequence of the unique cytokines that they secrete. CD4 serves a prominent role in potentiating antigen recognition by helper T cells. We have exa
Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains.: J Exp Med. 1997 Jul 7;186(1):17-23. Unique Identifier : AIDSLINE MED/97351116; Suzuki H; Shinkai Y; Granger LG; Alt FW; Love PE; Singer A; Experimental Immunology Branch, National Cancer Institute, Bethesda,; Maryland 20892, USA.; As a consequence of positive selection in the thymus, immature CD4(+)8(+) double-positive, [DP] thymocytes selectively terminate synthesis of one coreceptor molecule and, as a result, differentiate into either CD4(+) or CD8(+) T cells. The decision by individual DP thymocytes to terminate synthesis of one or the other
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.: J Exp Med. 1997 Jul 7;186(1):47-55. Unique Identifier : AIDSLINE MED/97351119; Shuford WW; Klussman K; Tritchler DD; Loo DT; Chalupny J; Siadak AW; Brown TJ; Emswiler J; Raecho H; Larsen CP; Pearson TC; Ledbetter JA; Aruffo A; Mittler RS; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.; The 4-1BB receptor is an inducible type I membrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily that is rapidly expressed on the surface of CD4+ and CD8+ T cells after antigen- or mitogen-induced activation. Cross-linking of 4-1BB and the T cell receptor (TCR) on activated T cells has be
Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-I) transgenic mice with autoimmune arthropathy.: J Exp Med. 1997 Jul 7;186(1):57-64. Unique Identifier : AIDSLINE MED/97351120; Kishi S; Saijyo S; Arai M; Karasawa S; Ueda S; Kannagi M; Iwakura Y; Fujii M; Yonehara S; Pharmaceutical Basic Research Laboratories JT Inc., Yokohama 236,; Japan.; Transgenic mice carrying the env-pX region of human T lymphocyte virus type I (HTLV-I) develop autoimmune arthropathy in high incidence. Adopting the approach that Fas-mediated apoptosis has a critical function in the elimination of self-reactive T cells, we examined the involvement of this apoptosis in the induction
Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help.: J Exp Med. 1997 Jul 7;186(1):65-70. Unique Identifier : AIDSLINE MED/97351121; Bennett SR; Carbone FR; Karamalis F; Miller JF; Heath WR; Thymus Biology Unit, The Walter and Eliza Hall Institute of Medical; Research, The Royal Melbourne Hospital, Melbourne, Victoria 3050,; Australia.; Class I-restricted presentation is usually associated with cytoplasmic degradation of cellular proteins and is often considered inaccessible to exogenous antigens. Nonetheless, certain exogenous elements can gain entry into this so-called endogenous pathway by a mechanism termed cross-presentation. This is known to be
Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells.: J Exp Med. 1997 Jul 7;186(1):7-16. Unique Identifier : AIDSLINE MED/97351115; Xu XN; Screaton GR; Gotch FM; Dong T; Tan R; Almond N; Walker B; Stebbings R; Kent K; Nagata S; Stott JE; McMichael AJ; Molecular Immunology, Institute of Molecular Medicine, John Radcliffe; Hospital, Oxford OX3 9DU, United Kingdom.; Inoculation of macaques with live attenuated SIV strains has been shown to protect against subsequent challenge with wild-type SIV. The protective mechanism(s) remain obscure. To study the effect in more detail, we have investigated the role of virus-specific CTL responses in macaques infected with an attenuated SIV s
Stability and change in psychosocial resources during caregiving and bereavement in partners of men with AIDS.: J Pers. 1997 Jun;65(2):421-47. Unique Identifier : AIDSLINE MED/97370638; Park CL; Folkman S; University of California, San Francisco, USA. parkcl@miavx1.muohio.edu; This study examines the effects of caregiving and bereavement on psychosocial resources in HIV+ and HIV- caregivers of men with AIDS. We explored three hypotheses regarding these effects: the wear and tear hypothesis, which asserts that the chronic stress of caregiving and bereavement diminishes resources; the enhanc
Therapeutic hyperthermia in cancer and AIDS: an updated survey.: J Environ Pathol Toxicol Oncol. 1996;15(2-4):289-97. Unique Identifier : AIDSLINE MED/97359908; Pontiggia P; Rotella GB; Sabato A; Curto FC; Department of Hyperthermia and Oncology, Clinica Citta di Pavia,; Italy.; The aim of this paper is to update with personal contributions the progress thus far accomplished in the clinical application of hyperthermia (HT) in cancer and chronic infectious diseases. The HT treatment has been successfully developed since the 1970s in cancer patients in whom it showed positive results consisting
Carotenoids in cancer, mastalgia, and AIDS: prevention and treatment--an overview.: J Environ Pathol Toxicol Oncol. 1996;15(2-4):89-95. Unique Identifier : AIDSLINE MED/97359875; Santamaria L; Bianchi-Santamaria A; dell'Orti M; Camillo Golgi Institute of General Pathology, Centro Prevenzione; Tumori, University of Pavia, Italy.; In 1980, two carotenoids, beta-carotene (BC) and canthaxanthine CX) with and without pro-vitamin A activity, respectively, were orally administered to female Swiss albino mice and were found to substantially prevent skin carcinogenesis induced by benzo(a)pyrene (BP). This preventive effect was observed in darkness by
In vivo evaluation of zidovudine (AZT)-loaded ethylcellulose microspheres after oral administration in beagle dogs.: J Pharm Sci. 1997 May;86(5):554-9. Unique Identifier : AIDSLINE MED/97290732; Abu-Izza K; Tambrallo L; Lu DR; College of Pharmacy, University of Georgia, Athens 30602, USA.; The purpose of this study was to evaluate the in vivo performance of sustained-release zidovudine ( AZT ) microspheres after oral administration in Beagle dogs, and to establish an in vitro-in vivo correlation. Two AZT microsphere formulations as well a
The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB.: J Pharmacol Exp Ther. 1997 Jul;282(1):459-66. Unique Identifier : AIDSLINE MED/97366758; Breton JJ; Chabot-Fletcher MC; Department of Immunopharmacology, SmithKline Beecham Pharmaceuticals,; King of Prussia, Pennsylvania 19406-0939, USA.; The nuclear factor-kappaB (NF-kappaB) family of transcription factors have been implicated in the inducible expression of genes involved in inflammatory and immune responses. As such, a specific inhibitor of NF-kappaB would be a useful therapeutic agent in a variety of inflammatory disorders. The marine natural produc
Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors.: J Pharmacol Exp Ther. 1997 Jul;282(1):505-12. Unique Identifier : AIDSLINE MED/97366763; Essayan DM; Kagey-Sobotka A; Lichtenstein LM; Huang SK; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21224, USA.; Our study explores the relative efficacy of phosphodiesterase PDE) inhibitors on antigen-specific Th1 and Th2 clonal responses. Proliferative responses for both phenotypes were down-regulated by the PDE4 inhibitor, rolipram, but not the PDE3 inhibitor, siguazodan. The Th2 clones were more sensitive than the Th1 clones
Electron microscopic immunocytological profiles in chronic fatigue syndrome.: J Psychiatr Res. 1997 Jan-Feb;31(1):115-22. Unique Identifier : AIDSLINE MED/97345286; Holmes MJ; Diack DS; Easingwood RA; Cross JP; Carlisle B; Department of Microbiology, University of Otago, Dunedin, New Zealand.; mike.holmes@stonebow.otago.ac.nz; Structures consistent in size, shape and character with various stages of a Lentivirus replicative cycle were observed by electron microscopy in 12-day peripheral-blood lymphocyte cultures from 10 of 17 Chronic Fatigue Syndrome patients and not in controls. Attempts to identify a lymphoid phenotype containing these st
How can psychological theory help to promote condom use in sub-Saharan African developing countries?: J R Soc Health. 1997 Jun;117(3):186-91. Unique Identifier : AIDSLINE MED/97339280; Campbell T; Hillingdon Hospital, Middlesex.; Condom use for HIV prevention has been very inconsistent in most sub-Saharan African countries. Studies from around the continent report that knowledge about HIV transmission is variable and seems to be related to gender, socioeconomic and educational status. There is a large body of psychological knowledge about HIV
Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.: J Med Chem. 1997 Jun 20;40(13):1969-76. Unique Identifier : AIDSLINE MED/97351655; McDonnell NB; De Guzman RN; Rice WG; Turpin JA; Summers MF; Howard Hughes Medical Institute, University of Maryland Baltimore; County 21228, USA.; The highly conserved and mutationally intolerant retroviral zinc finger motif of the HIV-1 nucleocapsid protein (NC) is an attractive target for drug therapy due to its participation in multiple stages of the viral replication cycle. A literature search identified cystamine, thiamine disulfide, and disulfiram as compo
Potent HIV protease inhibitors containing a novel hydroxyethyl)amide isostere.: J Med Chem. 1997 Jul 4;40(14):2164-76. Unique Identifier : AIDSLINE MED/97359919; Beaulieu PL; Wernic D; Abraham A; Anderson PC; Bogri T; Bousquet Y; Croteau G; Guse I; Lamarre D; Liard F; Paris W; Thibeault D; Pav S; Tong L; Bio-Mega Research Division, Boehringer Ingelheim (Canada) Ltd., Laval; (Quebec), Canada.; A series of HIV protease inhibitors containing a novel hydroxyethyl)amidosuccinoyl core has been synthesized. These peptidomimetic structures inhibit viral protease activity at low nanomolar concentrations (IC50
Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity.: J Med Chem. 1997 Jul 4;40(14):2191-5. Unique Identifier : AIDSLINE MED/97359922; Winter H; Maeda Y; Uchida H; Mitsuya H; Zemlicka J; Department of Chemistry, Barbara Ann Karmanos Cancer Institute, Wayne; State University School of Medicine, Detroit, Michigan 48201-1379,; USA.; The effect of introduction of a lipophilic phosphodiester amidate moiety on the HIV activity of inactive unsaturated nucleoside analogues was investigated. Phosphodiester alaninates 5a, 5b, and 6 derived from unsaturated nucleoside analogues 3b, 3c, and 4a were synthesized and investigated as inhibitors of cytopathic
Candida infection following severe trauma exacerbates Th2 cytokines and increases mortality.: J Surg Res. 1997 May;69(2):399-407. Unique Identifier : AIDSLINE MED/97367711; Mack VE; McCarter MD; Naama HA; Calvano SE; Daly JM; Department of Surgery, New York Hospital-Cornell, University Medical; College, New York 10021, USA.; Following trauma, there is an increase of Th2 cytokines (IL-4, IL-6, and IL-10) and a decrease in Th1 cytokines (IFN-gamma and IL-2 ) that may account for impaired cellular immunity. However, the functional significance of a dominant Th2 pattern to the host remains uncl
Sp family members preferentially interact with the promoter proximal repeat within the HTLV-I enhancer.: Leukemia. 1997 Apr;11 Suppl 3:10-3. Unique Identifier : AIDSLINE MED/97353023; Wessner R; Yao J; Wigdahl B; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey 17033, USA.; Human T cell lymphotropic virus type I (HTLV-I) encodes the transactivator protein, Tax, which facilitates viral transcription from three 21 bp repeated elements within the U3 region of the long terminal repeat (LTR). Examination of the basal factors interacting with the 21 bp repeat elements through electrophoretic m
Mutational analysis of the 5' noncoding region of human immunodeficiency virus type 1 genome.: Leukemia. 1997 Apr;11 Suppl 3:102-5. Unique Identifier : AIDSLINE MED/97353054; Hirota M; Koyanagi Y; An DS; Iwanaga Y; Yamamoto N; Shimotohno K; Virology Division, National Cancer Center Research Institute, Tokyo.; Retrovirus particles are released by budding from the membranes of infected cells. In the course of virus production, particularly during the late stage, viral genomic RNA is incorporated specifically into virion particles. This specific incorporation of the genomic RNA requires a packaging signal sequence. A region t
High levels of viremia in hu-PBL-NOD-scid mice with HIV-1 infection.: Leukemia. 1997 Apr;11 Suppl 3:109-12. Unique Identifier : AIDSLINE MED/97353056; Koyanagi Y; Tanaka Y; Tanaka R; Misawa N; Kawano Y; Tanaka T; Miyasaka M; Ito M; Ueyama Y; Yamamoto N; Department of Molecular Virology, Tokyo Medical and Dental University,; Japan.; We studied the compatibility of human lymphocyte engraftment and susceptibility to HIV-1 infection in 2 new immunodeficient mice. NOD/Shi-scid mice were generated by backcrossing of the scid mutation into NOD mice while C57BL/6-RAG2(0/0) were generated by knocking out the RAG-2 gene. Human T lymphocytes were reconstit
Acquired cytotoxic activity of CD8+ HIV-1IIIB carrier immature T cell clones specific to CD4+CD8+ (parental) human T cell clones and normal thymocytes.: Leukemia. 1997 Apr;11 Suppl 3:116-9. Unique Identifier : AIDSLINE MED/97353058; Toki M; Nishizaki C; Otani T; Minowada J; Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc.,; Okayama, Japan.; By infecting human leukemia cell lines in vitro with HIV-1IIIB a number of HIV-1 carrier clones were generated. Among them, 5 of 13 CD8+ HIV-1 carrier T cell clones were shown to acquire a rapid cytotoxic activity (within 1 hour) specific to TdT+CD4+CD8+ immature T cells including normal thymocytes. This novel cytoto
Peptide inhibitors of HIV-1 and HIV-2 proteases: a comparative study.: Leukemia. 1997 Apr;11 Suppl 3:120-2. Unique Identifier : AIDSLINE MED/97353059; Pichova I; Weber J; Litera J; Konvalinka J; Vondrasek J; Soucek M; Strop P; Majer P; Heuser AM; Kraeusslich HG; Institute of Organic Chemistry and Biochemistry, Czech. Acad. Sci.,; Prague, Czech Republic.; HIV-1 and HIV-2 proteases (PR) which play the key role in the formation of infectious viral particles offer a target for inhibitors that could block the maturation step. Inhibitors o HIV-1 PR exhibit mostly 1-2 orders of magnitude weaker affinity for HIV-2 PR. The subsite specificity study of the HIV-1 and HIV-2 prote
Lifetime treatment of mice with azidothymidine (AZT) produces myelodysplasia.: Leukemia. 1997 Apr;11 Suppl 3:123-7. Unique Identifier : AIDSLINE MED/97353060; Inoue T; Cronkite EP; Hirabayashi Y; Bullis JE Jr; Mitsui H; Umemura T; Department of Pathology, Yokohama City University School of Medicine,; Japan.; AZT has induced a macrocytic anemia in AIDS patients on long term AZT therapy. It is generally assumed that DNA elongation is stopped by the insertion of AZT into the chain in place of thymidine thus preventing the phosphate hydroxyl linkages and ther
Anti-human immunodeficiency virus activity of oligosaccharides from rooibos tea (Aspalathus linearis) extracts in vitro.: Leukemia. 1997 Apr;11 Suppl 3:128-30. Unique Identifier : AIDSLINE MED/97353061; Nakano M; Nakashima H; Itoh Y; Institute for Medical Science of Aging, Aichi Medical University,; Japan.; The active substances, acid polysaccharides, were extracted with 1% sodium hydroxide from the leaves of rooibos tea (Aspalathus linearis), Du Zhong Cha (Eucommia ulmoides Oliv.) and Japanese tea leaves (Camellia sinensis var. sinensis). The alkaline extracts of Rooibos tea and Du-Zhong tea leaves, but not Japanese tea
In vivo sequence changes of HIV-1 envelope V2 and V3 loops.: Leukemia. 1997 Apr;11 Suppl 3:131-3. Unique Identifier : AIDSLINE MED/97353062; Shioda T; Oka S; Nagai Y; Department of Viral Infection, University of Tokyo, Japan.; Human immunodeficiency virus type 1 (HIV-1) circulates in vivo as heterogeneous mixed populations (quasispecies). We analyzed the quasispecies nature of the first, second, and third hypervariable loops (V1, V2, and V3) of the gp 120 in plasma and viral isolates obtained from 19 infected individuals. Sequence analysis
Inhibition of HIV-1 replication by targeting the Rev protein.: Leukemia. 1997 Apr;11 Suppl 3:134-7. Unique Identifier : AIDSLINE MED/97353063; Nakaya T; Iwai S; Fujinaga K; Otsuka E; Ikuta K; Institute of Immunological Science, Faculty of Pharmaceutical Science,; Hokkaido University, Sapporo, Japan.; Human immunodeficiency virus type 1 (HIV-1) encodes two regulatory proteins, Tat and Rev. The Rev protein facilitates the transport of unspliced and singly-spliced RNA to the cytoplasm in infected host cells by binding to target RNA (Rev response element: RRE). A variety of approaches targeting Rev function, including
Molecular analyses of HIV-1 group O and HIV-2 variants from Africa.: Leukemia. 1997 Apr;11 Suppl 3:138-41. Unique Identifier : AIDSLINE MED/97353064; Hunt JC; Brennan CA; Golden AM; Yamaguchi J; Lund JK; Vallari AS; Hickman RK; Zekeng L; Gurtler LG; Hampl H; Kaptue L; Devare SG; Abbott Laboratories, North Chicago, IL-60064, USA.; Genetic variation among HIV isolates creates challenges for their detection by serologic and genetic techniques. To characterize the sequence variation and its correlation to serologic diversity of HIV-1 Group O and HIV-2 isolates, samples were identified by differential reactivity in selected commercial and research
Tissue and differentiation specific expression on the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line.: Leukemia. 1997 Apr;11 Suppl 3:142-4. Unique Identifier : AIDSLINE MED/97353065; Larsson E; Venables P; Andersson AC; Fan W; Rigby S; Botling J; Oberg F; Cohen M; Nilsson K; Department of Pathology, Uppsala University Hospital, Sweden.; ERV3 (HERV-R) is a complete, single copy human endogenous retrovirus located on the long arm of chromosome 7. The open reading frame in its envelope gene has been conserved during evolution but the gag and pol genes contain in-frame termination codons. To find a suitable experimental model system for analysis of the f
Pathogenesis of Friend leukemia virus.: Leukemia. 1997 Apr;11 Suppl 3:152-4. Unique Identifier : AIDSLINE MED/97353069; Ikawa Y; Department of Retroviral Regulation, Tokyo Medical and Dental; University Medical Research Division, Japan.; Friend leukemia virus complex (FLV) consists of replication-defective, Friend spleen focus-forming virus (F-SFFV) and replication-competent, Friend murine leukemia virus (F-MuLV). We produced transgenic mice possessing F-SFFV gp55 gene and clarified that the gp55 glycoprotein encoded by F-SFFV env-related gene is, by
Mutational analysis of the structure-function relationship of the leukemogenic membrane glycoprotein (GP55) of Friend spleen focus-forming virus (F-SFFV).: Leukemia. 1997 Apr;11 Suppl 3:160-1. Unique Identifier : AIDSLINE MED/97353071; Amanuma H; Yugawa T; Watanabe N; Ikawa Y; Laboratory of Gene Technology and Safety, Tsukuba Life Science Center,; Ibaraki, Japan.; Friend spleen focus-forming virus (F-SFFV) causes acute erythroleukemia in adult mice. F-SFFV encodes an envelope protein-like membrane glycoprotein called gp55 in its defective env gene. Gp55 is responsible for the early stage of leukemogenesis by F-SFFV by specifically binding to and activating the murine erythropoi
Interaction of the MAIDS defective virus with its host.: Leukemia. 1997 Apr;11 Suppl 3:162. Unique Identifier : AIDSLINE MED/97353072; Jolicoeur P; Laboratory of Molecular Biology, Clinical Research Institute of; Montreal, Quebec, Canada.
Possible origin of murine AIDS-inducing sequence.: Leukemia. 1997 Apr;11 Suppl 3:163-6. Unique Identifier : AIDSLINE MED/97353073; Kubo Y; Higo K; Kobayashi H; Ono T; Iwama Y; Yanagawa S; Adachi A; Ishimoto A; Department of Viral Oncology, Kyoto University, Japan.; The murine AIDS (MAIDS) virus has a unique sequence in its gag p12 region. A transcript which hybridizes with this sequence is expressed in normal C57BL/6 mice. This transcript has been proposed to be the origin of the MAIDS virus, since the virus was originally isolated from radiation-induced leukemic C57BL/6 mice. T
Immunologic havoc induced by the 60 kD Gag protein of the MAIDS defective virus.: Leukemia. 1997 Apr;11 Suppl 3:167-9. Unique Identifier : AIDSLINE MED/97353074; Morse HC 3rd; Morawetz RA; Giese NA; Chattopadhyay SK; Tang Y; Fredrickson TN; Hartley JW; Laboratory of Immunopathology, NIAID, NIH, Bethesda, MD 20892, USA.; The mechanisms responsible for development of profound immunodeficiency and extensive lymphoproliferation that characterize infection of different species with retroviruses are only partially understood. In mice, it has been shown the activities of an unusual Gag protein are necessary and sufficient to induce these ab
Antigenic variability of an immunodominant region (239-261) of the surface glycoprotein of HTLV-I.: Leukemia. 1997 Apr;11 Suppl 3:17-20. Unique Identifier : AIDSLINE MED/97353025; Londos-Galgliardi D; Dalibart R; Goetz M; Dalbon P; Guillemain B; INSERM U328, Institut Bergonie, Bordeaux, France.; In the 239-261 region of the surface glycoprotein of HTLV-I, we delineated five epitopes recognized by antibodies present in sera from HTLV-I infected patients. Three epitopes are located between the amino acids 252 and 261, one is of a linear type and the two others of a conformational type. One epitope is comprised
Molecular characterization of a piscine retrovirus, walleye dermal sarcoma virus.: Leukemia. 1997 Apr;11 Suppl 3:172-5. Unique Identifier : AIDSLINE MED/97353076; Holzschu DL; Fodor SK; Quackenbush SL; Earnest-Koons K; Bowser PR; Vogt VM; Casey JW; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, New York 14853, USA.
Possible relationships between canine hematopoietic neoplasia, other malignancies and immune mediated diseases.: Leukemia. 1997 Apr;11 Suppl 3:187-8. Unique Identifier : AIDSLINE MED/97353080; Theilen G; School of Veterinary Medicine, University of California, Davis; 95016-8745, USA.; In the last ten years few retroviruses have been isolated. The reasons for this lack of new discoveries are obvious, most retroviral investigations have been directed to HIV, HTLVI and HTLVII research with little research attention given to other species that may have retroviral infections, such as the dog. The domest
Immunosuppression by metastatic lymphoma derived altered retroviral gp70 molecule.: Leukemia. 1997 Apr;11 Suppl 3:202-5. Unique Identifier : AIDSLINE MED/97353083; Hao W; Messbarger L; Joshi SS; Department of Cell Biology & Anatomy, University of Nebraska Medical; Center, Omaha 68198-6395, USA.; In this report we describe the characteristics of an immunosuppressive molecule from an Abelson Leukemia Virus transformed highly malignant and metastatic RAW117-H10 murine large cell lymphoma cells. Our studies have shown that the mitomycin-c treated or irradiated RAW117-H10 cells very significantly (p
Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection.: Leukemia. 1997 Apr;11 Suppl 3:206-8. Unique Identifier : AIDSLINE MED/97353084; Morimura T; Ohashi K; Kon Y; Hattori M; Sugimoto C; Onuma M; Department of Disease Control, Graduate School of Veterinary Medicine,; Hokkaido University, Sapporo, Japan.; Histological study revealed that Marek s disease virus (MDV) can cause apoptosis in peripheral blood lymphocytes (PBL) in latently infected chickens. Analysis of DNA fragmentation indicated that CD4+T cells but not CD8+T cells underwent apoptosis. These apoptotic changes were also observed in the thymus during the acu
AP-1 derived from mature monocytes and astrocytes preferentially interacts with the HTLV-I promoter central 21 bp repeat.: Leukemia. 1997 Apr;11 Suppl 3:21-4. Unique Identifier : AIDSLINE MED/97353026; Wessner R; Wigdahl B; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey 17033, USA.; Characterization of the cellular transcription factors interacting with the human T cell lymphotropic virus type I HTLV-I) long terminal repeat (LTR) is essential to dissecting the mechanisms involved in viral transcription that may be pertinent to the oncogenic and neuropathogenic processes associated with HTLV-I inf
The role of tumor-associated antigen in bovine leukemia virus-induced lymphosarcoma.: Leukemia. 1997 Apr;11 Suppl 3:216-8. Unique Identifier : AIDSLINE MED/97353087; Aida Y; Nishino Y; Amanuma H; Murakami K; Okada K; Ikawa Y; Laboratory of Gene Technology and Safety, Institute of Physical and; Chemical Research (RIKEN), Ibaraki, Japan.; Bovine leukemia virus (BLV) is associated with enzootic bovine leukosis (EBL), which is the most common neoplastic disease of cattle. To clarify the way in which BLV-infected cattle progress from the asymptomatic stage to the lymphoma stage, we produced a monoclonal antibody (MAb) c143 which recognized a tumor-associa
Levels and role of cytokines in bovine leukemia virus (BLV) infection.: Leukemia. 1997 Apr;11 Suppl 3:219-20. Unique Identifier : AIDSLINE MED/97353088; Meirom R; Moss S; Brenner J; Heller D; Trainin Z; Kimron Veterinary Institute, Bet-Dagan, Israel.; Bovine leukemia virus belongs to a small subfamily of exogenous retroviruses that includes the human retroviruses HTLV-1, HTLV-II and the simian virus, STLV-1. Like other retroviruses, infection with BLV results in deregulation of the host immune system at both humoral and cellular levels. An approach which might help
Tumor-associated antigen in lymph nodes during the progression of enzootic bovine leukosis.: Leukemia. 1997 Apr;11 Suppl 3:221-2. Unique Identifier : AIDSLINE MED/97353089; Koguchi A; Goryo M; Aida Y; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Morioka, Japan.; A monoclonal antibody, (MAb) c143, that recognizes a tumor-associated antigen (TAA) that is upregulated on neoplastic B cells in cattle with enzootic bovine leukosis (EBL), was used as a marker to study disease progression. Immunohistochemical examination of neoplastic tissue and lymph nodes from animals with EBL, rev
Peptide-based bovine leukemia virus (BLV) vaccine that induces BLV-Env specific Th-1 type immunity.: Leukemia. 1997 Apr;11 Suppl 3:223-6. Unique Identifier : AIDSLINE MED/97353090; Ohishi K; Kabeya H; Amanuma H; Onuma M; Laboratory of Gene Technology and Safety, Tsukuba Life Science Center,; Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.; In controlling retrovirus infection and replication, cell-mediated immunity (CMI) is considered to be effective. To develop a synthetic peptide vaccine capable of inducing CMI, mannan-coated liposome encapsulating 20-mer synthetic peptide, spanning the 98-117 amino acids of bovine leukemia virus (BLV) envelope glycopr
Cell-free transmission of Fv-4 resistance gene product controlling Friend leukemia virus-induced leukemogenesis in mice.: Leukemia. 1997 Apr;11 Suppl 3:230-2. Unique Identifier : AIDSLINE MED/97353092; Kitagawa M; Aizawa S; Ikeda H; Hirokawa K; Department of Pathology and Immunology, Faculty of Medicine, Tokyo; Medical and Dental University, Japan.; Fv-4 is a mouse gene that dominantly confers resistance to infection by ecotropic murine leukemia virus (MuLV). The Fv-4 env antigen that binds to the cell surface of Fv-4 -bearing C3H cells was found in sera from normal Fv-4 -bearing C4W mice. The serum Fv-4 env antigen binds to ecotropic MuLV receptors, shown by s
Factors affecting induction of neurological disorder in mice by PVC viruses and the sequence of env-LTR region of PVC441.: Leukemia. 1997 Apr;11 Suppl 3:236-8. Unique Identifier : AIDSLINE MED/97353094; Kai K; Mitsuno K; Tanaka A; Oka K; Jinno A; Goto N; Ami Y; Andoh S; Department of Veterinary Microbiology, Faculty of Agriculture,; Yamaguchi University, Japan.; PVC111, PVC211, PVC321 and PVC441 cause neurological disorders associated with tremor and paralysis in rats. We tested the pathogenicity of these viruses in mice. Although histopathological studies revealed spongiform degeneration in the spinal cords of NFS mice infected with each PVC virus, only PVC441 caused a high
Models of HTLV-I-induced diseases. Infectious transmission of HTLV-I in inbred rats and HTVL-I env-pX transgenic rats.: Leukemia. 1997 Apr;11 Suppl 3:245-6. Unique Identifier : AIDSLINE MED/97353096; Yoshiki T; Ikeda H; Tomaru U; Ohya O; Kasai T; Yamashita I; Morita K; Yamazaki H; Ishizu A; Nakamaru Y; Kikuchi K; Tanaka S; Wakisaka A; Department of Pathology, Hokkaido Univ. Sch. Med., Sapporo, Japan.; To examine the pathogenic roles of HTLV-I in HTLV-I-induced diseases, we developed two models; namely HTLV-I carrier rats and HTLV-I env-pX transgenic rats. Among life long HTLV-I carriers in seven rat strains, only WKAH rats with the RT1k haplotype developed chronic progressive myeloneuropathy, resembling HAM/TSP cli
Expression of cell cycle-regulatory genes in HTLV-I-transformed T-cells and Tax1-immortalized T-cells.: Leukemia. 1997 Apr;11 Suppl 3:25. Unique Identifier : AIDSLINE MED/97353027; Akagi T; Ono H; Shimotohno K; Virology Division, National Cancer Center Research Institute, Tokyo,; Japan.
HTLV-I induced myeloneuropathy in WKAH rats: apoptosis and local activation of the HTLV-I pX and TNF-alpha genes implicated in the pathogenesis.: Leukemia. 1997 Apr;11 Suppl 3:255-7. Unique Identifier : AIDSLINE MED/97353099; Ohya O; Tomaru U; Yamashita I; Kasai T; Morita K; Ikeda H; Wakisaka A; Yoshiki T; Department of Pathology, Hokkaido University School of Medicine,; Sapporo, Japan.; To investigate the pathogenesis of HTLV-I associated diseases, we established a rat model for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in WKAH rats. In the spinal cords of WKAH rats carrying HTLV-I, chronological histopathology revealed the occurrence of apoptotic cell death starting at 9 mo
HTLV-I env-pX transgenic rats: prototype animal model for collagen vascular diseases.: Leukemia. 1997 Apr;11 Suppl 3:258-9. Unique Identifier : AIDSLINE MED/97353100; Yamazaki H; Ikeda H; Ishuzu A; Shikishima H; Kikuchi K; Wakisaka A; Hatanaka M; Yoshiki T; Department of Pathology, Hokkaido University School of Medicine,; Sapporo, Japan.; To evaluate the function of HTLV-I env-pX gene in vivo, we developed two lines of transgenic rats (env-pX rats) that expressed env-pX gene products, under control of own LTR promotor. In various tissues of the rats, env and pX mRNAs were constitutively expressed, irrespective of age. At age 5 weeks, swelling of the bi
Establishment of HTLV-1 carrier mice by injection with HTLV-1-producing T cells.: Leukemia. 1997 Apr;11 Suppl 3:260-2. Unique Identifier : AIDSLINE MED/97353101; Kushida S; Maeda N; Fang J; Uchida K; Miwa M; Department of Biochemistry, University of Tsukuba, Ibaraki, Japan.; We injected with HTLV-1-producing T-cells, MT-2, into C3H/HeJ and Balb/c mice intraperitoneally within 24 hours after birth and at one week old. At 3 months old, HTLV-1 provirus was detected in peripheral blood mononuclear cells in both mice. It was also detected in lymph nodes, thymus, spleen and liver of those mice.
A new retroviral AIDS-like disease and/or acute leukemia induced in mice by alloimmune stimuli.: Leukemia. 1997 Apr;11 Suppl 3:263-6. Unique Identifier : AIDSLINE MED/97353102; Ter-Grigorov V; Krifuks O; Liubashevsky E; Nyska A; Toder V; Trainin Z; Kimron Veterinary Institute, Bet Dagan, Israel.; We have shown a new phenomenon demonstrating that BALB/c female mice mated to C57BL/6 males during a year (7-10 pregnancies) develop AIDS-like disease or acute leukemia after an additional immunization with fixed ConA activated paternal (C57BL/6) lymphocytes. The AIDS-like disease is sexually and vertically transmissi
HIRF: a novel nuclear factor that binds to the human T-cell leukemia virus type I internal regulatory element (HIRE).: Leukemia. 1997 Apr;11 Suppl 3:29-31. Unique Identifier : AIDSLINE MED/97353029; Ariumi Y; Copeland TD; Nosaka T; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.; The transcription of human T-cell leukemia virus type I (HTLV-I) provirus starts from a promoter located in the 5 long terminal repeat (LTR). We have identified a second promoter at the 3 end of the pol gene. This internal promoter expresses the Tax transactivator protein, but does not require Tax for its activity.
Transcriptional activation and self-association in yeast: protein-protein dimerization as a pleiotropic mechanism of HTLV-I Tax function.: Leukemia. 1997 Apr;11 Suppl 3:3-6. Unique Identifier : AIDSLINE MED/97353021; Jin DY; Jeang KT; Molecular Virology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-0460, USA.; The yeast one-hybrid and two-hybrid systems for the detection of protein-DNA and protein-protein interactions were used as an in vivo approach to investigate the functional characteristics of HTLV-1 Tax expressed in yeast. Tax, when targeted to the upstream activating sequence (UAS) via the DNA-binding domain of Gal4
Chromosome changes associated with growth potential of HTLV-I infected human lymphocytes.: Leukemia. 1997 Apr;11 Suppl 3:32-4. Unique Identifier : AIDSLINE MED/97353030; Kawamura K; Koshikawa N; Mochizuki S; Maruyama K; Div. Pathol., Chiba Cancer Center Research Institute, Japan.; The association between chromosomal changes and cellular growth potential was investigated in HTLV-I infected human lymphocytes. Cell lines studied include Coculture-5 (HTLV-I infected immortalized cells dependent of IL-2 ), Coculture-15 and -18 semi-transformed Cocultu
Cytokine mediated growth inhibition of HTLV-I infected transformed human lymphocytes.: Leukemia. 1997 Apr;11 Suppl 3:35-7. Unique Identifier : AIDSLINE MED/97353031; Mochizuki S; Kawamura K; Koshikawa N; Maruyama K; Div. Pathol., Chiba Center Research Institute, Japan.; The interaction between HTLV-I infected immortalized cells and transformed cells was studied. HTLV-I infected immortalized human lymphocytes (Coculture-5) dependent of IL-2 medium (IL-2+PHA+TPA) and transformed cells (UV-5) derived from Coculture-5 following UV irradia
Antibodies directed against a variable and neutralizable region of the HTLV-I envelope surface glycoprotein.: Leukemia. 1997 Apr;11 Suppl 3:38-41. Unique Identifier : AIDSLINE MED/97353032; Londos-Gagliardi D; Armengaud MH; Freund F; Dalibart R; Moze E; Huet S; Legrand E; Guillemain BJ; INSERM U328, Institut Bergonie, Bordeaux, France.; The majority of neutralizing antibodies of HTLV-I are directed against linear epitopes of the envelope surface glycoprotein gp46) in the immunodominant region 175-199. Although gp46 presents a remarkable degree of conservation, the substitution of the proline at position 192 by a serine is described for 10 isolates am
Inhibition of syncytium formation by antisense oligonucleotide phosphorothioates complementary to tax mRNA of human T-cell leukemia virus type 1 (HTLV-1).: Leukemia. 1997 Apr;11 Suppl 3:42-4. Unique Identifier : AIDSLINE MED/97353033; Maeda N; Hoshino H; Kushida S; Miyano-Kurosaki N; Yamamoto N; Yokota T; Mizuguchi M; Makino K; Uchida K; Miwa M; Department of Biochemistry and Molecular Oncology, University of; Tsukuba, Ibaraki, Japan.; HTLV-1 infection is known as the factor to cause adult T-cell leukemia (ATL). Antisense oligonucleotide phosphorothioates against tax gene and control oligonucleotide phosphorothioates were synthesized. Antisense oligonucleotide was complementary to the region of initiation codon of tax gene. Two control oligonucleoti
Activation of the JAK1-STAT5 pathway by binding of the Friend virus gp55 glycoprotein to the erythropoietin receptor.: Leukemia. 1997 Apr;11 Suppl 3:432-4. Unique Identifier : AIDSLINE MED/97353157; Yamamura Y; Senda H; Noda M; Ikawa Y; Department of Retroviral Regulation, Tokyo Medical and Dental; University, Tokyo, Japan.; Friend spleen focus forming-virus (F-SFFV) induces acute erythroleukemia in susceptible mice. Initiation of the erythroleukemia is due to binding of the env-related glycoprotein gp55 encoded by F-SFFV to the erythropoietin receptor (EPOR). The gp55/EPOR interaction induces prolonged and growth factor independent proli
Substrates and inhibitors of human T-cell leukemia virus type 1 HTLV-1) proteinase.: Leukemia. 1997 Apr;11 Suppl 3:45-6. Unique Identifier : AIDSLINE MED/97353034; Hruskova-Heidingsfeldova O; Blaha I; Urban J; Strop P; Pichova I; Czech Academy of Sciences, Institute of Organic Chemistry and; Biochemistry, Prague, Czech Republic.; Human T-cell leukemia virus type 1 (HTLV-1) proteinase, a 125 residue polypeptide, was chemically synthesized using the solid phase method. The crude product was purified, renaturated and proteolytic activity was tested using oligopeptide substrates derived from processing sites of various retroviral polyproteins. Cle
Different properties of human T-cell leukemia virus type I prepared from 8C cat cells and human cells.: Leukemia. 1997 Apr;11 Suppl 3:47-9. Unique Identifier : AIDSLINE MED/97353035; Haraguchi Y; Jinno A; Takeuchi Y; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Maebashi, Japan.
Phylogenetic relationships of HTLV-I/STLV-I in the world.: Leukemia. 1997 Apr;11 Suppl 3:50-1. Unique Identifier : AIDSLINE MED/97353036; Yamashita M; Miura T; Ibuki K; Takehisa J; Chen J; Ido E; Hayami M; Institute for Virus Research, Kyoto University, Japan.; In an effort to delineate the origin and evolution of HTLV-I/STLV-I, we have been conducting phylogenetic analyses on LTR sequences of this virus group. HTLV-I isolates newly analyzed in the present study were from Iran , South Africa ,
Substitutions T-->C 4783 and T-->C 6569 in the pol and env genes of HTLV-I are characteristic for the isolates originating in the Middle East.: Leukemia. 1997 Apr;11 Suppl 3:52-3. Unique Identifier : AIDSLINE MED/97353037; Voevodin A; Department of Microbiology, Faculty of Medicine, Kuwait University,; Kuwait.
Kenneth MacGredie Memorial Lectureship. Adult T-cell leukemia/lymphoma.: Leukemia. 1997 Apr;11 Suppl 3:54-6. Unique Identifier : AIDSLINE MED/97353038; Takatsuki K; Kumamoto University School of Medicine, Japan.; Adult T-cell leukemia (ATL) was first reported in Japan , where it has a high incidence in the southwestern region. The retrovirus, human T-lymphotropic virus type I (HTLV-I), is the causative agent of ATL. In ATL-endemic areas, the rate of HTLV-I carriers is high. A definite diagnos
Dual phasic suppression of viral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers.: Leukemia. 1997 Apr;11 Suppl 3:545-7. Unique Identifier : AIDSLINE MED/97353194; Kannagi M; Nakamura T; Akari H; Kuroda MJ; Fujii M; Oka S; Iwamoto A; Kurata T; Higashi D; Harada S; Department of Immunotherapeutics, Tokyo Medical and Dental University,; Japan.; Replication of human immunodeficiency virus type 1 (HIV-1) is suppressed in asymptomatic HIV-1 carriers (ACs). By using an in vitro experimental system, the mechanism of this suppression was investigated. Following in vitro infection of a laboratory HIV-1 strain, the peripheral blood mononuclear cells (PBMC) of ACs tr
Primary prevention of HTLV-1 in Japan.: Leukemia. 1997 Apr;11 Suppl 3:57-9. Unique Identifier : AIDSLINE MED/97353039; Hino S; Katamine S; Miyata H; Tsuji Y; Yamabe T; Miyamoto T; Department of Virology, Faculty of Medicine, Tottori University,; Yonago, Japan.; The Nagasaki Prefecture, Japan (population: 1.5 million), is one of the hot endemic foci of Human T-lymphotropic virus type 1 HTLV-1). Prevalence of HTLV-1 carriers are approximately 10% in the age group over 40 years old (40,000 individuals), approximately 10 times of the national
Immunoregulation by B7 and IL-12 gene transfer.: Leukemia. 1997 Apr;11 Suppl 3:572-6. Unique Identifier : AIDSLINE MED/97353200; Kato K; Okumura K; Yagita H; Department of Immunology, Juntendo University School of Medicine,; Tokyo, Japan.; Our recent studies using various costimulatory molecules have demonstrated that antitumor effect could be induced by B7- or B70-transduced mouse tumors. To augment antitumor effect in vivo, the combination therapy with a costimulatory gene and a cytokine, interkeukin 1
Protective and therapeutic immunity against leukemia induced by irradiated B7-1 (CD80)-transduced leukemic cells.: Leukemia. 1997 Apr;11 Suppl 3:577-81. Unique Identifier : AIDSLINE MED/97353201; Hirano N; Takahashi T; Takahashi T; Azuma M; Yazaki Y; Yagita H; Hirai H; Third Department of Internal Medicine, University of Tokyo.; B7 molecules provide an important costimulatory signal for T cell receptor/CD3-mediated T cell activation via binding to their cognate receptors, CD28 and CTLA-4. We have introduced B7-1 CD80) into M1 cells, spontaneously-occurred mouse myelocytic leukemic cells and assessed its potential in the induction immunity to
HTLV-1 uveitis (HU).: Leukemia. 1997 Apr;11 Suppl 3:582-4. Unique Identifier : AIDSLINE MED/97353202; Watanabe T; Mochizuki M; Yamaguchi K; Department of Pathology, University of Tokyo.; We reported HTLV-1 uveitis (HU) as the third distinct clinical entity associated with HTLV-1 infection. Uveitis has advantages for studying the pathogenetic mechanisms of inflammatory diseases caused by HTLV-1, since observation of the disease process is relatively easy and clinical samples from the lesion can be obta
Short-term breast-feeding may reduce the risk of vertical transmission of HTLV-I. The Tsushima ATL Study Group.: Leukemia. 1997 Apr;11 Suppl 3:60-2. Unique Identifier : AIDSLINE MED/97353040; Takezaki T; Tajima K; Ito M; Ito S; Kinoshita K; Tachibana K; Matsushita Y; Division of Epidemiology, Aichi Cancer Center Research Institute,; Nagoya, Japan.; To establish a desirable preventive measure against mother-to-child transmission of HTLV-I through breast milk, we conducted a prospective study to investigate the seroconversion rate among children born to HTLV-I carrier mothers on two highly HTLV-I-endemic islands where 8% of pregnant women carry HTLV-I. Between 198
HTLV-I associated myelopathy (HAM): review and recent studies.: Leukemia. 1997 Apr;11 Suppl 3:63-4. Unique Identifier : AIDSLINE MED/97353041; Osame M; Arimura K; Nakagawa M; Umehara F; Usuku K; Ijichi S; Third Department of Internal Medicine, Faculty of Medicine, Kagoshima; University, Japan.
Pathogenesis and prevention of HTLV-1-associated diseases.: Leukemia. 1997 Apr;11 Suppl 3:65-6. Unique Identifier : AIDSLINE MED/97353042; Miwa M; Kushida S; Maeda N; Fang J; Kawamura T; Kameyama T; Uchida K; Department of Biochemistry and Molecular Oncology, University of; Tsukuba, Japan.; HTLV-1 is an important factor involved in various diseases including adult T-cell leukemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. Amount of HTLV-1 provirus integrated in human peripheral blood mononuclear cells might be a candidate for a risk factor in the manifestation of HTLV-1 assoc
HTLV-I provirus in the clinical subtypes of ATL.: Leukemia. 1997 Apr;11 Suppl 3:67-9. Unique Identifier : AIDSLINE MED/97353043; Matsuoka M; Tamiya S; Takemoto S; Yamaguchi K; Takatsuki K; Adult T cell leukemia (ATL) is an aggressive neoplasm of mature helper T cell, which is etiologically linked with human T-lymphotropic virus type 1 (HTLV-I). We studied HTLV-I provirus in 61 cases of ATL with Southern blot analyses and long PCR. These methods detected defective virus in 34 cases (56%). Furthermore, it
HTLV-I Tax trans-activation and cell growth signaling.: Leukemia. 1997 Apr;11 Suppl 3:7-9. Unique Identifier : AIDSLINE MED/97353022; Nakamura M; Takasawa N; Ohbo K; Higashimura N; Ohtani K; Tanaka Y; Sugamura K; Human Gene Sciences Center, Tokyo Medical and Dental University,; Japan.; We have cloned two genes for cell surface molecules, capable of delivering the intracellular signals, which are modulated for their expression by Tax. One is the gamma chain of the interleukin-2 ( IL-2 ) receptor which is suggested to be critical for IL-2-dependent growt
HTLV-I pX transgenic rats: development of cytokine-producing mammary carcinomas and establishment of the pX mammary carcinoma cell lines.: Leukemia. 1997 Apr;11 Suppl 3:70-2. Unique Identifier : AIDSLINE MED/97353044; Shikishima H; Ikeda H; Yamada S; Yamazaki H; Kikuchi K; Wakisaka A; Kasai N; Shimotono K; Yoshiki T; Department of Pathology, Hokkaido University School of Medicine,; Sapporo, Japan.; In two lines of transgenic rats (pX rats) from WKAH and F344 strains and carrying the HTLV-I pX gene under control of the mouse H-2Kd promoter, mammary carcinomas developed predominantly in females starting at about 5 months of age. The incidence of the tumor reached about 40% when the rats were 12 months old. Histolo
Immunopathogenesis of HTLV-I associated neurologic disease: massive latent HTLV-I infection in bone marrow of HAM/TSP patients.: Leukemia. 1997 Apr;11 Suppl 3:73-5. Unique Identifier : AIDSLINE MED/97353045; Jacobson S; Krichavsky M; Flerlage N; Levin M; Viral Immunology Section, National Institutes of Health, Bethesda, MD; 20892, USA.; The localization of mammalian retroviruses to specified immune organs has significant implications on the pathophysiology of retroviral associated diseases. Human T-cell Lymphotropic Virus Type I (HTLV-I) is considered a CD4+ lymphotropic virus although the virus has been shown to infect a large variety of cells in vi
Pleiotropic expression of heterologous cytokine/receptor genes in HTLV-1 associated diseases: candidate TRS for chimeric gene therapy.: Leukemia. 1997 Apr;11 Suppl 3:79-81. Unique Identifier : AIDSLINE MED/97353047; Greenberg SJ; Choi U; Overturf PM; Glenister N; Robinson TA; Lis A; Hohmann P; Goldman BD; Oseroff AR; Plunkett RJ; Department of Neurology, Roswell Park Cancer Institute, Buffalo, New; York 14263, USA.; DNA motifs that encode for specific transcriptional regulatory sequences (TRS) when engineered adjacent to the structural protein coding domain of a suicide enzyme can provide cell-lineage specific protein expression. The disparate up-regulation of several genes in adult T-cell leukemia (ATL) versus HTLV-1 associated
Neuropathology of HTLV-1-associated myelopathy (HAM/TSP).: Leukemia. 1997 Apr;11 Suppl 3:82-4. Unique Identifier : AIDSLINE MED/97353048; Izumo S; Umehara F; Kashio N; Kubota R; Sato E; Osame M; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima; University, Japan.; In order to clarify pathogenesis of HAM/TSP, we performed a detailed neuropathologic analysis of seven autopsy patients with HAM/TSP. Inflammatory infiltrates of mononuclear cells and degeneration of myelin and axons were noted in the middle to lower thoracic spinal cords and were continuously extended to the entire s
Increased fidelity of drug-selected M184V mutated HIV-1 reverse transcriptase as the basis for the effectiveness of 3TC in HIV clinical trials.: Leukemia. 1997 Apr;11 Suppl 3:85-8. Unique Identifier : AIDSLINE MED/97353049; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Canada.; HIV-infected individuals, who received 3TC monotherapy over one year, generally had lower plasma viral burden than at base-line. This was in spite of high-level resistance to this compound and the appearance of the M184V substitution in the HIV revers
Cross-resistance analysis and molecular modeling of nonnucleoside reverse transcriptase inhibitors targeting drug-resistance mutations in the reverse transcriptase of human immunodeficiency virus.: Leukemia. 1997 Apr;11 Suppl 3:89-92. Unique Identifier : AIDSLINE MED/97353050; Yang SS; Pattabiraman N; Gussio R; Pallansch L; Buckheit RW Jr; Bader JP; Antiviral Evaluations Branch, NCI, Bethesda, MD, USA.; Oxathlin carboxanilide analogs (UC) and alpha APA, compounds recognized as nonnucleoside reverse transcriptase (RT) inhibitors NNRTI), were evaluated for activity against the human immunodeficiency virus (HIV-1) and drug-resistant variants. These NNRTIs are structurally diverse but potent inhibitors of HIV-1 with effi
Genetic variation within human immunodeficiency viruses generates rapid changes in tropism, virulence, and transmission.: Leukemia. 1997 Apr;11 Suppl 3:93-4. Unique Identifier : AIDSLINE MED/97353051; Essex M; Soto-Ramirez LE; Renjifo E; Wang WK; Lee TH; Harvard AIDS Institute, Boston, MA 02115, USA.; The human immunodeficiency viruses (HIV-1) undergo high rates of variation. Only a few point mutations in the envelope gene are required to switch the tropism of HIV-1 from a growth preference for monocytes to lymphocytes or to acquire lytic properties for rapid killing of infected T4 lymphocytes. Since heterosexual t
SIV/HIV-1 chimeric viruses having HIV-1 env gene: a new animal model and a candidate for attenuated live vaccine.: Leukemia. 1997 Apr;11 Suppl 3:95-7. Unique Identifier : AIDSLINE MED/97353052; Hayami M; Igarashi T; Institute for Virus Research, Kyoto University, Japan.; In order to generate an HIV-1, which is infectious to and induces AIDS-like disease in monkeys, an SIVmac/HIV-1 chimeric virus, designated NM-3rN, which was replication-competent in monkeys, was constructed by recombination between HIV-1 and SIV mac genomes. The NM-3rN enabled to evaluate the efficacy of HIV-1 Env-dir
Mechanism(s) of FIV vaccine protection.: Leukemia. 1997 Apr;11 Suppl 3:98-101. Unique Identifier : AIDSLINE MED/97353053; Pu R; Tellier MC; Yamamoto JK; Department of Pathobiology, College of Veterinary Medicine, University; of Florida, Gainesville 32610, USA.; Infection of domestic cats with the feline immunodeficiency virus FIV) represents an important veterinary health problem and a useful animal model for the development of vaccines against AIDS. Two experimental FIV vaccines have been developed: one consisting of fixed infected cells and the other of inactivated whole v
Rhinocerebral mucormycosis: evolution of the disease and treatment options.: Laryngoscope. 1997 Jul;107(7):855-62. Unique Identifier : AIDSLINE MED/97360091; Peterson KL; Wang M; Canalis RF; Abemayor E; Division of Head and Neck Surgery, UCLA School of Medicine, Los; Angeles, California 90095-1624, USA.; Rhinocerebral mucormycosis is recognized as a potentially aggressive and commonly fatal fungal infection. The classic presentation is involvement of nasal mucosa with invasion of the paranasal sinuses and orbit. Mucormycosis is most commonly seen in association with diabetic ketoacidosis, but disease demographics have
Factors affecting smoking cessation in patients with head and neck cancer.: Laryngoscope. 1997 Jul;107(7):888-92. Unique Identifier : AIDSLINE MED/97360097; Vander Ark W; DiNardo LJ; Oliver DS; Department of Otolaryngology, Medical College of Virginia/Virginia; Commonwealth University, Richmond 23298, USA.; The role of tobacco in the etiology of upper aerodigestive tract carcinomas is well established. Smoking decreases the effectiveness of cancer therapy and increases the risk of all treatment modalities. Smoking adversely affects the general health of the cancer survivor and places the patient at risk of developing add
Cell mediated immunity induced in mice by HPV 16 L1 virus-like particles.: Microb Pathog. 1997 Apr;22(4):219-25. Unique Identifier : AIDSLINE MED/97285700; Dupuy C; Buzoni-Gatel D; Touze A; Le Cann P; Bout D; Coursaget P; Laboratoire d'Immunologie des Maladies Infectieuses, Faculte de; Pharmacie, Tours, France.; Recombinant human papillomavirus (HPV) type 16 L1 virus-like particles (VLPs) expressed in the baculovirus system were used to investigate the cellular immune response to human papillomavirus type 16. The cell-mediated immune response was evaluated through immunization of mice with HPV 16 L1 virus-like particles using
[Tricuspid valve endocarditis. Demonstration of a rare disease exemplified with 3 case reports]: Med Klin. 1997 May 15;92(5):291-5. Unique Identifier : AIDSLINE MED/97323835; Zahn R; Schneider M; Thoma S; Zander M; Lotter R; Seidl K; Isgro F; Saggau W; Senges J; Herzzentrum Ludwigshafen.; BACKGROUND: Endocarditis of the tricuspid valve is a rare form of valvular endocarditis and occurs mainly in patients with special risk factors. CASE REPORTS: The three case reports demonstrate 3 young patients (age 30 to 37 years, 2 female and 1 male) with a typical history of those risk factors. The two women were i
The identification and molecular characterization of Trypanosoma cruzi amastigote surface protein-1, a member of the trans-sialidase gene super-family.: Mol Biochem Parasitol. 1997 May;86(1):1-11. Unique Identifier : AIDSLINE MED/97321553; Santos MA; Garg N; Tarleton RL; Department of Cellular Biology, University of Georgia, Athens 30602,; USA.; An accumulating body of evidence suggests that T. cruzi-infected host cells are recognized and destroyed by class I major histocompatibility complex (MHC) restricted CD8+ T-cells thus contributing to immune control of the infection [1-6]. However, to date, only a few amastigote proteins which could be the target of th
Reefer madness--the federal response to California's medical-marijuana law.: N Engl J Med. 1997 Aug 7;337(6):435-9. Unique Identifier : AIDSLINE MED/97377721; Annas GJ
Immunodeficiency viruses. Spoilt for choice of co-receptors [news; comment]: Nature. 1997 Jul 17;388(6639):230-1. Unique Identifier : AIDSLINE MED/97373944; Clapham PR; Weiss RA
A new SIV co-receptor, STRL33 [letter] [see comments]: Nature. 1997 Jul 17;388(6639):238. Unique Identifier : AIDSLINE MED/97373948; Alkhatib G; Liao F; Berger EA; Farber JM; Peden KW
Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.: Neuroscience. 1997 May;78(1):135-46. Unique Identifier : AIDSLINE MED/97280768; Masliah E; Westland CE; Rockenstein EM; Abraham CR; Mallory M; Veinberg I; Sheldon E; Mucke L; Department of Neurosciences, University of California at San Diego, La; Jolla 92093-0624, U.S.A.; The beta-amyloid protein precursor (APP) is well conserved across different species and may fulfill important physiological functions within the CNS. While high-level neuronal expression of amyloidogenic forms of human APP results in beta-amyloid production and neurodegeneration, lower levels of neuronal human APP exp
[Hospital follow-up of patients with HIV infection: towards new modalities of management (letter)]: Presse Med. 1997 Jun 7;26(19):904. Unique Identifier : AIDSLINE MED/97375808; May T; Doco-Lecompte T; Rabaud C; Burty C; Schuhmacher H; Canton P; Service de Maladies infectieuses, Hopitaux de Brabois, CHU de Nancy,; Vandoeuvre.
[Primary cerebral lymphoma in AIDS. Retrospective study of 20 patients]: Presse Med. 1997 Jun 14;26(20):940-4. Unique Identifier : AIDSLINE MED/97380819; de La Blanchardiere A; Lesprit P; Molina JM; Zagdanski AM; Hennequin C; Garrait V; Decazes JM; Modai J; Service des Maladies infectieuses et tropicales, Hopital Saint-Louis,; Paris.; OBJECTIVES: Analyze the epidemiological pattern of primary central nervous system lymphoma in AIDS patients together with the clinical expression and course under treatment. METHODS: We retrospectively reviewed 20 patients with AIDS-associated primary central nervous system lymphoma hospitalized in our unit between Ap
[At the Academie Nationale de Medecine. Prenatal screening of anti-HIV antibodies]: Presse Med. 1997 Jun 14;26(20):958-9. Unique Identifier : AIDSLINE MED/97380826; Henrion R; Academie Nationale de Medecine, Paris.
X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase.: Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7162-5. Unique Identifier : AIDSLINE MED/97352768; Xu Y; Sellam O; Morera S; Sarfati S; Biondi R; Veron M; Janin J; Laboratoire d'Enzymologie et de Biochimie Structurales, Unite Propre; de Recherche 9063, Centre National de la Recherche Scientifique, 91198; Gif-sur-Yvette, France.; To be effective as antiviral agent, AZT 3 -azido-3 -deoxythymidine) must be converted to a triphosphate derivative by cellular kinases. The conversion is inefficient and, to understand why AZT diphosphate is a poor substrate of nucleoside diphosphate
Recombinant parvovirus-like particles as an antigen carrier: a novel nonreplicative exogenous antigen to elicit protective antiviral cytotoxic T cells.: Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7503-8. Unique Identifier : AIDSLINE MED/97352828; Sedlik C; Saron M; Sarraseca J; Casal I; Leclerc C; Unite de Biologie des Regulations Immunitaires, Institut Pasteur, 25; rue du Docteur Roux, 75724 Paris cedex 15, France.; To develop a strategy that promotes efficient antiviral immunity, hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus VP2 capsid protein carrying a CD8(+) T cell epitope from the lymphocytic choriomeningitis virus nucleoprotein. Immunization of mice with these hybrid pse
GPIIIa-(49-66) is a major pathophysiologically relevant antigenic determinant for anti-platelet GPIIIa of HIV-1-related immunologic thrombocytopenia.: Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7589-94. Unique Identifier : AIDSLINE MED/97352843; Nardi MA; Liu LX; Karpatkin S; Department of Pediatrics, New York University Medical Center, 550; First Avenue, New York, NY 10016, USA.; High-affinity (Kd = 1 x 10(-9) M) anti-platelet GPIIIa has been isolated from serum immune complexes of immunologic thrombocytopenic HIV-1-infected patients (HIV-1-ITP). Affinity-purified anti-platelet antibody reacted with a recombinant GPIIIa-(1-200) and -(1-66) fusion peptide and with an 18-mer GPIIIa-(49-66) pepti
Immunologically induced electrophysiological dysfunction: implications for inflammatory diseases of the CNS and PNS.: Prog Neurobiol. 1997 May;52(1):1-26. Unique Identifier : AIDSLINE MED/97328717; Koller H; Siebler M; Hartung HP; Department of Neurology, Heinrich-Heine University Dusseldorf,; Germany.; During inflammation of the central or peripheral nervous system, a high number of immunologically active molecules, including bacterial or viral products as well as host-derived cytokines, are released. Patients suffering from inflammatory CNS or PNS diseases often develop transient symptoms with a rapid recovery, whi
[Sepsis due to Pasteurella multocida in an HIV-positive patient letter)]: Recenti Prog Med. 1997 May;88(5):226. Unique Identifier : AIDSLINE MED/97344567; Garavelli PL
[Kidney colic under Indinavir [correction of indiavir] therapy in HIV infection]: Schweiz Rundsch Med Prax. 1997 Apr 30;86(18):767-8. Unique Identifier : AIDSLINE MED/97322448; Junghanss BG; Medizinische Universitats-Poliklinik, Departement fur Innere Medizin,; Kantonsspital Basel.
[Oral ulcers in HIV infection]: Schweiz Rundsch Med Prax. 1997 May 21;86(21):912-3. Unique Identifier : AIDSLINE MED/97332015; Bassetti S; Courvoisier S; Itin P; Medizinische Universitatspoliklinik, Kantonsspital Basel.
[Pulmonary complications of human immunodeficiency virus infection in sub-Saharan Africa]: Rev Pneumol Clin. 1997;53(2):79-84. Unique Identifier : AIDSLINE MED/97349765; Domoua K; N'Dhatz M; Coulibaly G; Traore F; Koffi J; Achi V; Cisse L; Kouame S; Beugre LK; Konan JB; Yapi A; Service de Pneumo-phtisiologie, CHU de Treichville, Abidjan, Cote; d'Ivoire.; Based on a selection of articles published in the literature and reports from international AIDS conferences, we present the main pulmonary complications of HIV-infection observed in sub-Saharan Africa. The different clinical studies demonstrate the predominance of infectious complications, mainly tuberculosis (29 to
[CMV infections in patients infected by HIV. Diagnosis, course, principles of treatment]: Rev Prat. 1997 May 1;47(9):1017-22. Unique Identifier : AIDSLINE MED/97352413; Jouan M; Katlama C; Service des maladies infectieuses et tropicales, groupe hospitalier; Pitie-Salpetriere, Paris.
Effectiveness of condoms in preventing HIV transmission.: Soc Sci Med. 1997 May;44(9):1303-12. Unique Identifier : AIDSLINE MED/97285946; Pinkerton SD; Abramson PR; Center for AIDS Intervention Research, Medical College of Wisconsin,; Milwaukee, USA.; The consistent use of latex condoms continues to be advocated for primary prevention of HIV infection despite limited quantitative evidence regarding the effectiveness of condoms in blocking the sexual transmission of HIV. Although recent meta-analyses of condom effectiveness suggest that condoms are 60 to 70% effecti
Anthropological research and the politics of HIV prevention: towards a critique of policy and priorities in the age of AIDS.: Soc Sci Med. 1997 May;44(9):1381-91. Unique Identifier : AIDSLINE MED/97285953; Waterston A; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, Columbia University, USA.; This paper is based on the author s ethnographic HIV prevention research at a community-based residence for women in New York City who have a history of homelessness and diagnosis of mental illness. The author presents the human face of this American tragedy, while exploring the ways in which larger social forces circ
Acquired immunodeficiency syndrome in Alabama: special concerns for black women.: South Med J. 1997 Jul;90(7):697-701. Unique Identifier : AIDSLINE MED/97369403; Holmes R; Fawal H; Moon TD; Cheeks J; Coleman J; Woernle C; Vermund SH; Bureau of Disease Control, Alabama Department of Public Health,; Montgomery, USA.; BACKGROUND: Among AIDS case reports from rural and small town areas of the United States , rates are higher in the South than in any other part of the country. METHODS: For this study, we analyzed AIDS surveillance statistics from the state of Alabama for trends, distributions, and popu
The changing demographics of AIDS in Texas.: Tex Med. 1997 Jun;93(6):19. Unique Identifier : AIDSLINE MED/97352887
Minimizing the risk.: Tex Med. 1997 Jun;93(6):45-7. Unique Identifier : AIDSLINE MED/97352893; Grimes RM; University of Texas-Houston Health Science Center, School of Public; Health, USA.
Living with AIDS.: Tex Med. 1997 Jun;93(6):47-8. Unique Identifier : AIDSLINE MED/97352894; Moran T
Soluble adhesion molecules and endothelial cell damage in HIV infected patients.: Thromb Haemost. 1997 Apr;77(4):646-9. Unique Identifier : AIDSLINE MED/97280285; Seigneur M; Constans J; Blann A; Renard M; Pellegrin JL; Amiral J; Boisseau M; Conri C; University Hospital of Bordeaux II, France.; Endothelial damage is present in HIV infection but our understanding of markers and mechanisms is incomplete. We found increased levels of markers of endothelial cell damage such as von Willebrand factor (vWf), soluble thrombomodulin (sTM) and adhesion molecule E-selectin in 90 subjects seropositive for HIV relative t
Interstitial pneumonitis in bone marrow transplant recipients is associated with local production of TH2-type cytokines and lack of T cell-mediated cytotoxicity.: Transplantation. 1997 Jun 27;63(12):1782-9. Unique Identifier : AIDSLINE MED/97354210; Sparrelid E; Emanuel D; Fehniger T; Andersson U; Andersson J; Department of Immunology, Pathology, Microbiology and Infectious; Diseases, Karolinska Institute, Huddinge University Hospital, Sweden.; BACKGROUND: Interstitial pneumonitis, especially associated with cytomegalovirus ( CMV ) infection, is a serious complication after bone marrow transplantation (BMT), with a high fatality rate despite adequate antiviral treatme
Results of a survey of infectious disease testing practices by organ procurement organizations in the United States.: Transplantation. 1997 Jun 27;63(12):1790-4. Unique Identifier : AIDSLINE MED/97354211; Domen RE; Nelson KA; Department of Clinical Pathology, The Cleveland Clinic Foundation,; Ohio 44195, USA.; BACKGROUND: Information related to infectious disease testing policies and practices of organ procurement organizations in the United States does not currently exist. METHODS: A total of 63 organ procurement organizations in the United States were surveyed during May 1996. Participants
Abnormal differentiation of thymocytes induced by free cyclosporine is avoided when cyclosporine bound to N-(2-hydroxypropyl)methacrylamide copolymer carrier is used.: Transplantation. 1997 Jun 27;63(12):1818-27. Unique Identifier : AIDSLINE MED/97354217; St'astny M; Ulbrich K; Strohalm J; Rossmann P; Rihova B; Institute of Microbiology, Academy of Sciences of the Czech Republic,; Department of Immunology and Gnotobiology, Prague.; BACKGROUND: The side effects of cyclosporine (CsA)-including nephrotoxicity and abnormal differentiation of thymocytes developing in the thymus-can be decreased or even avoided using targeted conjugates of CsA, where both targeting moiety and drug are bound to water-soluble polymeric carrier based on N-(2-hydroxypropy
Surgery for pulmonary tuberculosis.: World J Surg. 1997 Jun;21(5):457-67. Unique Identifier : AIDSLINE MED/97348793; Perelman MI; Strelzov VP; Department of Pulmonology and Thoracic Surgery, Moscow Medical; Academy, Russian Institute for Phthisiopulmonology, Russia.; During the period 1990-1994 a total of 578 operations were performed in 502 patients with various forms of tuberculosis. Most of the patients (68%) were men aged 20 to 50 years (70%). Sputum cultures were positive in 55% of the patients. More than half of all patients were chronic smokers, and about 10% were alcoholic
Large bowel tuberculosis and possible influencing factors for surgical prognosis: 30 years' experience.: World J Surg. 1997 Jun;21(5):500-4. Unique Identifier : AIDSLINE MED/97348799; Chen WS; Su WJ; Wang HS; Jiang JK; Lin JK; Lin TC; Department of Surgery, Veterans General Hospital-Taipei, Taiwan,; Republic of China.; The incidence of tuberculosis is rising in the United States . Similarly, the incidence of pulmonary tuberculosis in Taiwan is increasing, but that of large bowel tuberculosis in this region has not b
Improvement of bioavailability of the HIV protease inhibitor SC-52151 in the beagle dog by coadministration of the CYP3A4 inhibitor, ketoconazole.: Xenobiotica. 1997 May;27(5):489-97. Unique Identifier : AIDSLINE MED/97323587; Yuan JH; Stolzenbach JC; Salamon CM; Snook SS; Schoenhard GL; G.D. Searle R & D, Skokie, IL 60077, USA.; 1. SC-52151, an HIV protease inhibitor, is mainly metabolized by CYP3A4 and is poorly bioavailable after oral administration. After i.v. administration of SC-52151 to the female beagle dog 2.5 mg/kg), SC-52151 was rapidly eliminated in plasma with an elimination half-life of about 1 h, a plasma clearance of 44 ml/min/
HIV infection and pregnancy.: Acta Obstet Gynecol Scand Suppl. 1997;164:134-6. Unique Identifier : AIDSLINE MED/97369171; Lindgren S; Department of Obstetrics and Gynecology, Huddinge Hospital, Sweden.
A new era in HIV care [editorial; comment]: Am Fam Physician. 1997 Jul;56(1):37, 40-2. Unique Identifier : AIDSLINE MED/97369173; Soloway B
Opportunistic infections and psychosocial stress in HIV [see comments]: Am Fam Physician. 1997 Jul;56(1):87-96. Unique Identifier : AIDSLINE MED/97369180; Montauk SL; Gebhardt B; Department of Family Medicine, University of Cincinnati, OH 45267,; USA.; Persons infected with the human immunodeficiency virus (HIV) are susceptible to both opportunistic infections and psychosocial crises at varying stages of their disease. Many interventions, including lifestyle changes and chemoprophylaxis, may help prevent, delay or lessen the extent of the morbidities associated with
Clinical significance of immature reticulocyte fraction determined by automated reticulocyte counting.: Am J Clin Pathol. 1997 Jul;108(1):69-73. Unique Identifier : AIDSLINE MED/97352585; Chang CC; Kass L; Department of Pathology, MetroHealth Medical Center and Case Western; Reserve University School of Medicine, Cleveland, Ohio 44109-1998,; USA.; The Sysmex R-3000 (TOA Medical Electronics, Kobe, Japan ) evaluates maturation of reticulocytes by quantitating the fraction of reticulocytes within low-, middle-, and high-fluorescence intensity regions. We defined the immature reticulocyte fraction (IRF) as the sum of the fraction
Rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis: the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial. The Studies of Ocular Complications of AIDS (SOCA) Research Group in Collaboration with the AIDS Clinical Trials Group (ACTG).: Am J Ophthalmol. 1997 Jul;124(1):61-70. Unique Identifier : AIDSLINE MED/97365397; PURPOSE: To determine the incidence and risk factors for rhegmatogenous retinal detachment in a population of patients with newly diagnosed cytomegalovirus retinitis. METHODS: Analysis of selected baseline and time-dependent data on patients enrolled in a multicenter, prospective,
DNA ploidy and HPV subtypes in cervical smears of HIV-sero-positive and negative patients.: Anticancer Res. 1997 May-Jun;17(3C):2259-63. Unique Identifier : AIDSLINE MED/97359782; Giovagnoli MR; Mancini R; Pachi A; Alderisio M; Scaravelli G; Giampa G; Carraro C; Vecchione A; Department of Experimental Medicine and Pathology, University La; Sapienza, Rome, Italy.; Epidemiological studies have demonstrated that cervical HPV infection and precancerous lesions of the cervix are more common in HIV-seropositive patients. However little is known about the natural history of these lesions in this population. In the present study cervical smears from 36 patients, 18 HIV-seropositive wo
The human immunodeficiency virus type 1 Tat protein potentiates zidovudine-induced cellular toxicity in transgenic mice.: Arch Biochem Biophys. 1997 Jul 15;343(2):173-80. Unique Identifier : AIDSLINE MED/97367960; Prakash O; Teng S; Ali M; Zhu X; Coleman R; Dabdoub RA; Chambers R; Aw TY; Flores SC; Joshi BH; Laboratory of Molecular Oncology, Alton Ochsner Medical Foundation,; New Orleans, Louisiana 70121, USA.; 3 -Azido-2 ,3 -dideoxythymidine ( AZT , zidovudine) is the principal antiretroviral agent in the treatment of AIDS. Although beneficial, AZT remains restricted for human usage because of its severe toxic effects. We examined the AZT sensitivity in trans
Recovery of gut-associated lymphoid tissue and upper respiratory tract immunity after parenteral nutrition.: Ann Surg. 1997 Jun;225(6):707-15; discussion 715-7. Unique Identifier : AIDSLINE MED/97374362; Janu P; Li J; Renegar KB; Kudsk KA; Department of Surgery, University of Tennessee at Memphis, USA.; OBJECTIVE: The authors characterize the recovery of parenteral nutrition-induced changes in gut-associated lymphoid tissue GALT) and upper respiratory tract immunity with enteral nutrition and provide further information defining the effects of enteral feeding on mucosal immunity. SUMMARY BACKGROUND DATA: The small in
Fulminant Pneumocystis carinii pneumonia in 4 patients with dermatomyositis.: Arch Intern Med. 1997 Jul 14;157(13):1501-3. Unique Identifier : AIDSLINE MED/97367527; Bachelez H; Schremmer B; Cadranel J; Mouly F; Sarfati C; Agbalika F; Schlemmer B; Mayaud CM; Dubertret L; Institut de Recherche sur la Peau, Hopital Saint-Louis, Paris, France.; Between 1989 and 1996, 4 cases of Pneumocystis carinii pneumonia PCP) were observed in patients seronegative for the human immunodeficiency virus who were receiving corticosteroid therapy for dermatomyositis in our institution. These cases were considered unusual in light of the short delay of their onset after initia
Role of ascorbate in the activation of NF-kappaB by tumour necrosis factor-alpha in T-cells.: Biochem J. 1997 Jul 1;325 ( Pt 1):23-8. Unique Identifier : AIDSLINE MED/97344237; Munoz E; Blazquez MV; Ortiz C; Gomez-Diaz C; Navas P; Departamento de Fisiologia e Inmunologia, Facultad de Medicina,; Universidad de Cordoba, Avda. Menendez Pidal s/n, 14071 Cordoba,; Spain.; The first product of ascorbate oxidation, the ascorbate free radical (AFR), acts in biological systems mainly as an oxidant, and through its role in the plasma membrane redox system exerts different effects on the cell. We have investigated the role of ascorbate, AFR and dehydroascorbate (DHA) in the activation of the
Detection of mouse skeletal muscle-specific product, which includes ZF5 zinc fingers and a VP16 acidic domain, by reverse transcriptase PCR.: Biochem Biophys Res Commun. 1997 Jul 9;236(1):20-5. Unique Identifier : AIDSLINE MED/97366588; Numoto M; Yokoro K; Yasuda S; Yanagihara K; Niwa O; Department of Molecular Pathology, Research Institute for Radiation; Biology and Medicine, Hiroshima University, Minami-ku, Japan.; mnumoto@ipc.hiroshima-u.ac.jp; ZF5, which we have cloned as a repressor on the mouse c-myc promoter, is a zinc finger protein containing Kruppel-type zinc finger and ZiN/POZ domains. In a reverse transcriptase PCR assay using mouse skeletal muscle RNA, we identified a 827 bp PCR product including the zinc finger domain of ZF5 and the acidic domain
Synthesis of a series of Homopterocarpane derivatives with potential antitumor and anti-AIDS activity.: Farmaco. 1997 Jan;52(1):13-9. Unique Identifier : AIDSLINE MED/97325622; Valenti P; Fabbri G; Rampa A; Bisi A; Belluti F; Dipartimento di Scienze Farmaceutiche, Universita di Bologna.; The synthesis of a series of derivatives related to (+/-) cis 6a, 12a-dihydro-6H,7H-[1]-benzopyrano-[4,3-b]-[1]-benzopyran Homopterocarpane) is described. The synthesized derivatives have been tested at National Cancer Institute in its in vitro anti-cancer and anti-AIDS screening programs. The synthesized compounds ar
Immune responses in goats to caprine arthritis-encephalitis virus.: Viral Immunol. 1997;10(2):111-5. Unique Identifier : AIDSLINE MED/97354064; Ding EY; Xiang WH; Institute of Genetics, Fudan University, Shanghai, The People's; Republic of China.; In this study, goats were experimentally infected with caprine arthritis-encephalitis virus (CAEV). Anti-CAEV antibodies were detected in vivo using indirect enzyme-linked immunosorbent assay ELISA) and Western blot assays. The results showed that the sensitivity of detection of anti-CAEV antibodies using indirect ELI
Impaired mitogen-driven proliferation and cytokine transcription of lymphocytes from macaques early after simian immunodeficiency virus (SIV) infection.: Viral Immunol. 1997;10(2):65-72. Unique Identifier : AIDSLINE MED/97354059; Spring M; Bodemer W; Stahl-Hennig C; Nisslein T; Hunsmann G; Dittmer U; Department of Virology and Immunology, German Primate Centre,; Gottingen, Germany.; Altered cytokine transcription might play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection in humans. The infection of rhesus macaques with simian immunodeficiency virus (SIV) provides a relevant animal model for HIV infection. Therefore, we evaluated the cyokine transcription of p
Simultaneous detection of hepatitis C virus and human immunodeficiency virus RNA in serum using amplicor PCR tests.: Viral Immunol. 1997;10(2):73-82. Unique Identifier : AIDSLINE MED/97354060; Wozny W; Piasek A; Elbaum D; Institute of Experimental Biology, Polish Academy of Sciences, Warsaw,; Poland.; Several tests are currently available to assist in the diagnosis of the hepatitis C virus (HCV) and human immunodeficiency virus HIV). Tests that actually detect or quantify these viruses are based on the polymerase chain reaction (PCR) technique. However, the application of PCR is limited by the cost, labor, time-con
Cell-mediated immunity to porcine reproductive and respiratory syndrome virus in swine.: Viral Immunol. 1997;10(2):83-94. Unique Identifier : AIDSLINE MED/97354061; Bautista EM; Molitor TW; Department of Clinical and Population Sciences, College of Veterinary; Medicine, University of Minnesota, St. Paul, USA.; Cell-mediated immunity has been demonstrated to be a necessary component of immunity against viral infection. Methods to detect T-cell mediated immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) infection were established both in vitro as lymphocyte proliferation and in vivo as delayed-typ
Apoptosis induction by human immunodeficiency virus type 1 HIV-1) gp120 peptides.: Viral Immunol. 1997;10(2):95-102. Unique Identifier : AIDSLINE MED/97354062; Pugliese O; Boirivant M; Viora M; Laboratory of Immunology, Istituto Superiore di Sanita, Rome, Italy.; We investigated the role of some gp120 peptides on the apoptosis induction in malignant T cell lines. We took advantage of recent findings reporting that three major regions of gp120 are important for CD4 binding. They consist of residues 256-262 in the C2 domain, residues 368-389 in the C3 domain, and residues 421-45
Uptake of interventions to reduce mother-to-child transmission of HIV in the United Kingdom and Ireland.: AIDS. 1997 Jun;11(7):F53-8. Unique Identifier : AIDSLINE MED/97333045; Gibb DM; MacDonagh SE; Tookey PA; Duong T; Nicoll A; Goldberg DJ; Hudson CN; Peckham CS; Ades AE; Department of Epidemiology and Biostatistics, Institute of Child; Health, London, UK.; OBJECTIVES: To describe the uptake of interventions to reduce mother-to-child transmission of HIV infection. DESIGN: Voluntary confidential reporting of HIV infection in pregnancy and childhood; telephone interview with key professionals in all London maternity units. SUBJECTS AND SETTING: HIV-infected pregnant women
HIV/AIDS and its risk factors in Pakistan.: AIDS. 1997 Jun;11(7):843-8. Unique Identifier : AIDSLINE MED/97333046; Khawaja ZA; Gibney L; Ahmed AJ; Vermund SH; School of Public Health, University of Alabama at Birmingham; 35294-0008, USA.
Germinal centre CD4+ T cells are an important site of HIV replication in vivo.: AIDS. 1997 Jun;11(7):849-57. Unique Identifier : AIDSLINE MED/97333047; Hufert FT; van Lunzen J; Janossy G; Bertram S; Schmitz J; Haller O; Racz P; von Laer D; Department of Virology, University of Freiburg, Germany.; OBJECTIVE: CD4+ T cells are the main target for HIV. However, the highest HIV antigen concentration in infected subjects accumulates on the cell surface of follicular dendritic cells in the germinal centres of the lymphoid tissue. Germinal centres contain a T-helper cell subset which expresses CD57 molecules. Here we
Subtype-specific problems with quantification of plasma HIV-1 RNA.: AIDS. 1997 Jun;11(7):859-65. Unique Identifier : AIDSLINE MED/97333048; Alaeus A; Lidman K; Sonnerborg A; Albert J; Division of Infectious Disease, Karolinska Institute, Danderyd; Hospital, Sweden.; OBJECTIVE: To determine whether two commercial assays for quantification of plasma HIV-1 RNA levels detect different genetic subtypes of HIV-1 with equal efficiency. DESIGN: Blind testing of stored plasma samples from 95 individuals infected with different genetic subtypes of HIV-1 (27 subtype A, 24 B, 18 C, 18 D, two
A case of ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with AIDS: longitudinal molecular analysis of the CMV viral load and viral mutations in blood compartments.: AIDS. 1997 Jun;11(7):867-73. Unique Identifier : AIDSLINE MED/97333049; Boivin G; Gilbert C; Morissette M; Handfield J; Goyette N; Bergeron MG; Infectious Disease Research Center, CHUL, Sainte-Foy, Quebec, Canada.; OBJECTIVE: To study the temporal relationships between cytomegalovirus ( CMV ) viral load and specific UL97 mutations in polymorphonuclear leukocytes (PMNL) and plasma samples from a patient with AIDS who developed ganciclovir-
Isoniazid preventive therapy for tuberculosis in HIV-1-infected adults: results of a randomized controlled trial.: AIDS. 1997 Jun;11(7):875-82. Unique Identifier : AIDSLINE MED/97333050; Hawken MP; Meme HK; Elliott LC; Chakaya JM; Morris JS; Githui WA; Juma ES; Odhiambo JA; Thiong'o LN; Kimari JN; Ngugi EN; Bwayo JJ; Gilks CF; Plummer FA; Porter JD; Nunn PP; McAdam KP; Department of Clinical Sciences, London School of Hygiene and Tropical; Medicine, UK.; OBJECTIVES: To determine the efficacy of isoniazid 300 mg daily for 6 months in the prevention of tuberculosis in HIV-1-infected adults and to determine whether tuberculosis preventive therapy prolongs survival in HIV-1-infected adults. DESIGN AND SETTING: Randomized, double-blind, placebo-controlled trial in Nairobi,
Cost-effectiveness of cytomegalovirus (CMV) disease prevention in patients with AIDS: oral ganciclovir and CMV polymerase chain reaction testing.: AIDS. 1997 Jun;11(7):883-7. Unique Identifier : AIDSLINE MED/97333051; Rose DN; Sacks HS; Department of Community Medicine, AIDS Center, Mount Sinai School of; Medicine, New York, New York 10029, USA.; OBJECTIVE: To perform a cost-effectiveness analysis of strategies to prevent cytomegalovirus ( CMV ) disease. METHOD: Markov model and published data. PATIENTS: Hypothetical HIV-infected patients with CD4 cell counts
Cytomegalovirus (CMV) viraemia detected by polymerase chain reaction identifies a group of HIV-positive patients at high risk of CMV disease.: AIDS. 1997 Jun;11(7):889-93. Unique Identifier : AIDSLINE MED/97333052; Bowen EF; Sabin CA; Wilson P; Griffiths PD; Davey CC; Johnson MA; Emery VC; Department of Thoracic/HIV Medicine, Royal Free Hospital and School of; Medicine, London, UK.; BACKGROUND: Cytomegalovirus ( CMV ) disease is a major cause of morbidity in patients with HIV infection. Despite treatment, CMV retinitis causes substantial visual loss, especially in patients with CD4 cell counts below 50 x 10(6)/l. Although routine ophthalmolog
Quantification of HIV-1 viral load in lymphoid and blood cells: assessment during four-drug combination therapy.: AIDS. 1997 Jun;11(7):895-901. Unique Identifier : AIDSLINE MED/97333053; Tamalet C; Lafeuillade A; Fantini J; Poggi C; Yahi N; Laboratory of Virology, Timone Hospital, Marseille, France.; OBJECTIVE: To assess the antiretroviral effect of a combination of zidovudine, didanosine, lamivudine and saquinavir in plasma, peripheral blood mononuclear cells (PBMC) and lymph-node mononuclear cells (LNMC) after 8 weeks. METHODS: Ten HIV-1 antiretroviral therapy-naive patients were given a combination of oral zido
Decreased incidence of sexually transmitted diseases among trucking company workers in Kenya: results of a behavioural risk-reduction programme.: AIDS. 1997 Jun;11(7):903-9. Unique Identifier : AIDSLINE MED/97333054; Jackson DJ; Rakwar JP; Richardson BA; Mandaliya K; Chohan BH; Bwayo JJ; Ndinya-Achola JO; Martin HL Jr; Moses S; Kreiss JK; Department of Medical Microbiology, University of Nairobi, Kenya.; OBJECTIVE: To establish a cohort of high-risk individuals suitable for HIV-prevention trials, and to measure changes in sexual behaviour and sexually transmitted disease (STD) incidence after a behavioural intervention. DESIGN: Prospective cohort study in trucking company depots in Mombasa,
Recent transmission of tuberculosis in a cohort of HIV-1-infected female sex workers in Nairobi, Kenya.: AIDS. 1997 Jun;11(7):911-8. Unique Identifier : AIDSLINE MED/97333055; Gilks CF; Godfrey-Faussett P; Batchelor BI; Ojoo JC; Ojoo SJ; Brindle RJ; Paul J; Kimari J; Bruce MC; Bwayo J; Plummer FA; Warrell DA; Clinical Research Centre, Kenya Medical Research Institute, Nairobi,; Kenya.; OBJECTIVES: To describe the epidemiological and clinical characteristics of HIV-related tuberculosis in a female cohort, and to investigate the relative importance of recently transmitted infection and reactivation in the pathogenesis of adult HIV-related tuberculosis. DESIGN: Members of an established cohort of femal
Modelling the economic benefits of tuberculosis preventive therapy for people with HIV: the example of Zambia.: AIDS. 1997 Jun;11(7):919-25. Unique Identifier : AIDSLINE MED/97333056; Foster S; Godfrey-Faussett P; Porter J; Department of Public Health and Policy, London School of Hygiene and; Tropical Medicine, UK.; OBJECTIVE: To assess the economic benefits and costs of providing isoniazid preventive therapy for tuberculosis (TB) in HIV-infected persons in Zambia . DESIGN: A spreadsheet model incorporating variables drawn from published studies and unpublished data. SUBJECTS: Data drawn from a
Search for infectious HIV in gingival crevicular fluid and saliva of advanced AIDS patients with severe periodontitis [letter]: AIDS. 1997 Jun;11(7):927-8. Unique Identifier : AIDSLINE MED/97333057; Chebbi F; Poveda JD; Suzuki T; Tai H; Yoshie H; el Tenn R; de Saint-Martin J; Guetard D; Hara K; Dupont B; de The G
Low serum cholesterol and risk of death from AIDS [letter]: AIDS. 1997 Jun;11(7):929-30. Unique Identifier : AIDSLINE MED/97333058; Neaton JD; Wentworth DN
Identification of a novel HLA-B*3501-restricted cytotoxic T lymphocyte epitope using overlapping peptides [letter]: AIDS. 1997 Jun;11(7):930-2. Unique Identifier : AIDSLINE MED/97333059; Goulder PJ; Edwards A; Phillips RE; McMichael AJ
Evaluation of rapid on-site clinic HIV test, combined with counselling [letter]: AIDS. 1997 Jun;11(7):932-3. Unique Identifier : AIDSLINE MED/97333060; Mashu A; Mbizvo MT; Makura E; Bopoto R; Madzime S; Chipato T; Fottrell P
HIV care in the community: creation of a flowchart to assist in coordinating patient care and data management. Stamford HIV/AIDS Care Community Needs Team [letter]: AIDS. 1997 Jun;11(7):933-4. Unique Identifier : AIDSLINE MED/97333061; Parry MF; Israel SP; Coq R; Taliercio R; McElhatton S
HIV-1 and HIV-2 AIDS in African patients living in Paris [letter]: AIDS. 1997 Jun;11(7):934-6. Unique Identifier : AIDSLINE MED/97333062; Matheron S; Mendoza-Sassi G; Simon F; Olivares R; Coulaud JP; Brun-Vezinet F
Harm of not permitting personal HIV screening in developing countries [letter; comment]: AIDS. 1997 Jun;11(7):936-7. Unique Identifier : AIDSLINE MED/97333063; Frerichs RR
A placebo-controlled clinical phase I trial with combined anti-HIV-1 and anti-interferon-alpha immunization [letter]: AIDS. 1997 Jun;11(7):937-8. Unique Identifier : AIDSLINE MED/97333064; Coulaud IP; Gougeon ML; Gomard E; Descamps D; Lebon P; Aboulker JP; Bizzini B; Zagury D
Marked hyperlipidaemia on ritonavir therapy [letter]: AIDS. 1997 Jun;11(7):938-9. Unique Identifier : AIDSLINE MED/97333065; Sullivan AK; Nelson MR
Does HIV-2 protect against HIV-1 infection? [letter]: AIDS. 1997 Jun;11(7):939-40. Unique Identifier : AIDSLINE MED/97333066; Aaby P; Poulsen AG; Larsen O; Christiansen CB; Jensen H; Melbye M; Naucler A; Dias F
Dapsone and HIV-1 replication in primary cultures of lymphocytes and monocyte-derived macrophages [letter]: AIDS. 1997 Jun;11(7):943-4. Unique Identifier : AIDSLINE MED/97333068; Duval X; Clayette P; Dereuddre-Bosquet N; Fretier P; Martin M; Salmon-Ceron D; Gras G; Vilde JL; Dormont D
Low HIV prevalence among childbearing women of aboriginal origin [letter]: AIDS. 1997 Jun;11(7):945-7. Unique Identifier : AIDSLINE MED/97333070; Hankins C; Hum L; Tran T; Laberge C; Lapointe N; O'Shaughnessy M; Lepine D; Malloch L; Rud E; Robinson E
Similarity in language in "AIDS" article and "AJE" article [letter]: AIDS. 1997 Jun;11(7):947. Unique Identifier : AIDSLINE MED/97333071; Fordyce EJ
Deficiency of naive T cells in patients with sudden deafness.: Arch Otolaryngol Head Neck Surg. 1997 Jul;123(7):712-7. Unique Identifier : AIDSLINE MED/97379791; Garcia-Berrocal JR; Vargas JA; Ramirez-Camacho RA; Gonzalez FM; Gea-Banacloche JC; Vergara J; Durantez A; Service of Otorhinolaryngology, Clinica Puerta de Hierro, Autonoma; University, Madrid, Spain.; BACKGROUND: Although there are a number of reports concerned with the role of immunity in the sudden onset of progressive sensorineural hearing loss, there are few references dealing with the involvement of immune-mediated mechanisms in sudden deafness. OBJECTIVES: To study the phenotype of peripheral blood lymphocyte
Anti-HIV active naphthyl analogues of HEPT and DABO.: Acta Chem Scand. 1997 Mar;51(3 Suppl):426-30. Unique Identifier : AIDSLINE MED/97354067; Danel K; Nielsen C; Pedersen EB; Department of Chemistry, Odense University, Denmark.; 5-Ethyl-6-(1-naphthylmethyl)uracil and 5-ethyl-6-(1-naphthylmethyl)-2-thiouracil were alkylated to give, respectively. N-1 and S2, ethoxymethyl and methylthiomethyl uracil derivatives. 5-Ethyl-6-(1-naphthylmethyl)-2-thiouracil was also S2 alkylated with methyl bromoacetate. The products showed activity against HIV-1,
Effects of manganese salts on the AIDS-related pathogen, Cryptosporidium parvum in vitro and in vivo.: Biol Trace Elem Res. 1997 Mar;56(3):243-53. Unique Identifier : AIDSLINE MED/97341614; Nesterenko MV; Woods KM; Upton SJ; Division of Biology, Kansas State University, Manhattan 66506, USA.; coccidia/ksu.edu; The authors examined the effects of manganese salts on the interaction of the AIDS-related pathogen, Cryptosporidium parvum, with human ileoadenocarcinoma (HCT-8) cells in vitro. Manganese Mn) inhibited binding of C. parvum sporozoite membrane antigens to intact, fixed HCT-8 cells in a dose-dependent fashion, whereas
Characteristics of T cell lines established from skin lesions of Behcet's disease.: J Dermatol Sci. 1997 May;15(1):9-13. Unique Identifier : AIDSLINE MED/97330348; Mochizuki M; Morita E; Yamamoto S; Yamana S; Department of Dermatology, Hiroshima University School of Medicine,; Japan.; Hypersensitivity to a streptococcal antigen is postulated to be the pathogenesis of Behcet s disease. We analyzed T lymphocyte-phenotypes infiltrated in cutaneous pustular lesions in Behcet s disease and found that CD4+ T cells were predominant components although CD8+ T cells were also present in the lesion. In addit
Simple i.v. inoculation of HIV-1 to Thy/Liv SCID-hu mice induce reproducible HIV infection with narrowing of medulla in human thymic implant.: J Vet Med Sci. 1997 Apr;59(4):259-63. Unique Identifier : AIDSLINE MED/97297464; Okamoto Y; Ogura A; Shibata S; Amagai T; Katsura Y; Asano T; Honda M; AIDS Research Center, National Institute of Health, Tokyo, Japan.; Human fetal thymus/liver engrafted SCID mice were constructed and studied for its susceptibility to HIVBRU infection by i.v. inoculation which seemed to represent an appropriate route of HIV infection in vivo. By the i.v. inoculation of HIV, the medulla in the engrafted thymus narrowed significantly when compared with
Detection of bovine leukemia viruses (BLV) in mammary tissues of BLV antibody-positive cows affected by subclinical mastitis.: J Vet Med Sci. 1997 Apr;59(4):301-2. Unique Identifier : AIDSLINE MED/97297473; Yoshikawa H; Xie B; Oyamada T; Hiraga A; Yoshikawa T; Department of Veterinary Pathology, School of Veterinary Medicine and; Animal Sciences, Kitasato University, Aomori, Japan.; The mammary tissues of 6 cows with bovine leukemia virus (BLV) antibody and subclinical mastitis were investigated histopathologically, and their organ cultures were ultrastructurally observed. Numerous BLV particles, 110 to 120 nm in diameter, were seen around lymphocytes, which had infiltrated into mammary alveoli a
[The attitudes to and needs for education on HIV infection among primary care health professionals]: Aten Primaria. 1997 May 15;19(8):395-9. Unique Identifier : AIDSLINE MED/97327188; Casabella Abrill B; Llobera Serentill A; Perez Sanchez J; Sala Alvarez C; Garcia Ortega D; Facultad de Medicina de la UAB., Barcelona.; OBJECTIVE: To evaluate the attitudes, knowledge and training needs for primary care health professionals (PCP) dealing with HIV/AIDS infection. DESIGN: An observational, crossover study. SETTING: primary care: health districts in the Ciutat Vella health area of the city of Barcelona. PARTICIPANTS: 34 nursing professio
Functions of CD8 T-cell subsets secreting different cytokine patterns.: Semin Immunol. 1997 Apr;9(2):87-92. Unique Identifier : AIDSLINE MED/97337479; Mosmann TR; Li L; Sad S; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada.; CD8+ T cells can differentiate into two effector phenotypes, Tc1 and Tc2, secreting different cytokine patterns. Both subsets are cytotoxic via the perforin and Fas pathways, and both kill resting and activated B cells, ruling out the possibility of cognate help, although Tc2 cells may provide bystander help. Both sub
Treatment of chronic periodontitis: a site-specific fiber placement technique.: Pract Periodontics Aesthet Dent. 1996 Aug;8(6):565-70; quiz 572. Unique Identifier : AIDSLINE MED/97386119; Anderson HH; U.S. Navy, Jacksonville, Florida.; Bacterial flora has resisted the conventional treatment in a segment of patients with adult periodontitis, creating an interest in adjunctive chemotherapeutic treatment modalities. Tetracycline hydrochloride periodontal fiber, a locally delivered antibiotic therapy, is indicated as an adjunct to scaling and root plani
Donor-dependent and dose-dependent variation in the induction of T lymphocyte locomotion in a three-dimensional collagen matrix system by a mistletoe preparation (Iscador).: Anticancer Drugs. 1997 Apr;8 Suppl 1:S61-4. Unique Identifier : AIDSLINE MED/97322881; Nikolai G; Friedl P; Werner M; Zanker KS; Institute of Immunology, University of Witten/Herdecke, Germany.; Controlled activation of non-specific and specific immune defence mechanisms can beneficially manipulate the host s ability to attack malignant cells. In this context, migration and tissue distribution of immunocompetent cells may be prerequisites for an efficient immune surveillance. The effect of various non-cytotox
A pentamidine-treated acquired immunodeficiency syndrome patient associated with sudden onset diabetes mellitus and high tumor necrosis factor alpha level.: J Diabetes Complications. 1997 Jul-Aug;11(4):256-8. Unique Identifier : AIDSLINE MED/97345237; Ubukata E; Mokuda O; Nagata M; Ogino Y; Sakamoto Y; Tanaka K; Shimizu N; Department of Internal Medicine, Teikyo University School of Medicine,; Ichihara Hospital, Chiba, Japan.
Nutrition and HIV infection. 2nd International Conference under the aegis of the Society Francophone de Nutrition Enteral et Parenterale. Cannes, France, 23-25 April 1997. Abstracts.: Nutrition. 1997 Mar;13(3):263-94. Unique Identifier : AIDSLINE MED/97398098
Guidelines for managing HIV infection [editorial]: BMJ. 1997 Jul 5;315(7099):1-2. Unique Identifier : AIDSLINE MED/97377651; De Cock KM
Harm reduction measures and injecting inside prison versus mandatory drugs testing: results of a cross sectional anonymous questionnaire survey. The European Commission Network on HIV Infection and Hepatitis in Prison.: BMJ. 1997 Jul 5;315(7099):21-4. Unique Identifier : AIDSLINE MED/97377664; Bird AG; Gore SM; Hutchinson SJ; Lewis SC; Cameron S; Burns S; Churchill Hospital, Oxford.; OBJECTIVES: (a) To determine both the frequency of injecting inside prison and use of sterilising tablets to clean needles in the previous four weeks; (b) to assess the efficiency of random mandatory drugs testing at detecting prisoners who inject heroin inside prison; (c) to determine the percentage of prisoners who
Prevalence of HIV and injecting drug use in men entering Liverpool prison.: BMJ. 1997 Jul 5;315(7099):30-1. Unique Identifier : AIDSLINE MED/97377666; Bellis MA; Weild AR; Beeching NJ; Mutton KJ; Syed Q; Department of Public Health, University of Liverpool.; m.a.bellis@liv.ac.uk
Problems of patients testing positive for HIV [news]: Natl Med J India. 1997 May-Jun;10(3):144-5. Unique Identifier : AIDSLINE MED/97374158; Pandya SK
Refined solution structure and backbone dynamics of HIV-1 Nef.: Protein Sci. 1997 Jun;6(6):1248-63. Unique Identifier : AIDSLINE MED/97337445; Grzesiek S; Bax A; Hu JS; Kaufman J; Palmer I; Stahl SJ; Tjandra N; Wingfield PT; Laboratory of Chemical Physics, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0520, USA. grzesiek@speck.niddk.nih.gov; The tendency of HIV-1 Nef to form aggregates in solution, particularly at pH values below 8, together with its large fraction of highly mobile residues seriously complicated determination of its three-dimensional structure, both for heteronuclear solution NMR (Grzesiek et al., 1996a, Nat Struct Biol 3:340-345) and for
Understanding strategies for treating HIV.: Medsurg Nurs. 1997 Apr;6(2):109-11. Unique Identifier : AIDSLINE MED/97381791; Wilson BA; Nursing Program, Loyola University, New Orleans, LA, USA.; A great deal has been learned over the past 1 to 2 years about treatment of HIV infection. Viral load testing now provides a reliable method of assessing the effectiveness of any treatment regimen. And it is now clear that triple combinations of drugs typically two nucleoside analogues and one protease inhibitor) are
Neonatal infections.: Curr Opin Pediatr. 1997 Apr;9(2):133-40. Unique Identifier : AIDSLINE MED/97348189; Bhutta ZA; Aga Khan University Medical Center, Karachi, Pakistan.; Neonatal infections range from early-onset vertically acquired infections to nosocomial bacterial sepsis, and they account for significant morbidity and mortality globally. The recent emergence of perinatally acquired HIV-1 infection has also placed an enormous burden on existing meager health resources in developing
The impact of the EM algorithm on medical statistics [editorial]: Stat Methods Med Res. 1997 Mar;6(1):1-2. Unique Identifier : AIDSLINE MED/97328771; McLachlan G
Uses of the EM algorithm in the analysis of data on HIV/AIDS and other infectious diseases.: Stat Methods Med Res. 1997 Mar;6(1):24-37. Unique Identifier : AIDSLINE MED/97328773; Becker NG; School of Mathematical and Statistical Sciences, La Trobe University,; Bundoora, Australia. n.becker@latrobe.edu.au; The analysis of data on infectious diseases is a natural setting for applications of the EM algorithm, because the infection process is only partially observable. Difficulties in determining the expectation at the E step have been side-stepped by adopting pragmatic models which reflect only part of the mechanism that
Cytomegalovirus: the monster in the closet? [editorial]: Am J Respir Crit Care Med. 1997 Jul;156(1):1-2. Unique Identifier : AIDSLINE MED/97374268; Baughman RP
Opportunistic infections in pediatric HIV infection: a study of 74 autopsy cases from Latin America. The Latin American AIDS Pathology Study Group.: Pediatr Pathol Lab Med. 1997 Jul-Aug;17(4):569-76. Unique Identifier : AIDSLINE MED/97355354; Drut R; Anderson V; Greco MA; Gutierrez C; de Leon-Bojorge B; Menezes D; Peruga A; Quijano G; Ridaura C; Siminovich M; Mayoral PV; Weissenbacher M; Servicio de Patologia, Hospital de Ninos, La Plata, Argentina.; The present report describes opportunistic infections found at 74 autopsies of pediatric HIV/AIDS patients performed at several hospitals in Latin American countries. Fungal infections were the most common (53 cases), Candida sp. (39.18%) and Pneumocystis carinii (20.27%) being the most frequently recognized. Other fu
Disseminated calcification with predominant muscle and cerebral involvement in a child with acquired immunodeficiency syndrome: a case report.: Pediatr Pathol Lab Med. 1997 Jul-Aug;17(4):593-600. Unique Identifier : AIDSLINE MED/97355357; Liu J; Sulh MA; Zagzag D; Reuben R; Greco MA; Department of Pathology, New York University-Bellevue Hospital Medical; Center, New York, USA.; Calcification, as a feature of the vasculopathy, is a common pathological finding in children with acquired immunodeficiency syndrome. Large and small blood vessels of many organs including brain, heart, lungs, kidneys, liver, and spleen are affected. We report a case with calcification in multiple organs that was mos
Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.: Nat Struct Biol. 1997 Jul;4(7):567-77. Unique Identifier : AIDSLINE MED/97372895; Cai M; Zheng R; Caffrey M; Craigie R; Clore GM; Gronenborn AM; Laboratory of Chemical Physics, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0520, USA.; The solution structure of the N-terminal zinc binding domain residues 1-55; IN1-55) of HIV-1 integrase has been solved by NMR spectroscopy. IN1-55 is dimeric, and each monomer comprises four helices with the zinc tetrahedrally coordinated to His 12, His 16, Cys 40 and Cys 43. IN1-55 exists in two interconverting confo
Ketoconazole resistant oral candidiasis in HIV-infected patients [letter]: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jul;84(1):3-4. Unique Identifier : AIDSLINE MED/97391133; Diz Dios P; Vazquez Garcia E
Failure to implement U.S. needle-exchange program has cost many lives and dollars, study says [news]: Am J Health Syst Pharm. 1997 May 15;54(10):1149-50. Unique Identifier : AIDSLINE MED/97305356
Supportive care during aldesleukin therapy for patients infected with human immunodeficiency virus.: Am J Health Syst Pharm. 1997 May 15;54(10):1191-3. Unique Identifier : AIDSLINE MED/97305363; Gabriel CM; Minor JR; Vogel S; Piscitelli SC; Washington Hospital Center, Washington, DC, USA.
Low infant infection rate halts study of perinatal HIV transmission [news]: Am J Health Syst Pharm. 1997 May 1;54(9):1018, 1021. Unique Identifier : AIDSLINE MED/97288694
Intracellular inhibition of HIV-1 replication using a dual protein- and RNA-based strategy.: Gene Ther. 1997 Jun;4(6):533-43. Unique Identifier : AIDSLINE MED/97374620; Duan L; Zhu M; Ozaki I; Zhang H; Wei DL; Pomerantz RJ; Dorrance H Hamilton laboratories, Department of Medicine, Jefferson; Medical College, Thomas Jefferson University, Philadelphia,; Pennsylvania 19107, USA.; Exporting unspliced human immunodeficiency virus type 1 (HIV-1) RNA from the nucleus to the cytoplasm, through an interaction between the viral regulatory Rev protein and Rev response element RRE) RNA, is a critical step in the HIV-1 life-cycle. Disruption of either Rev or the RRE will completely inhibit HIV-1 replica
Immune responsiveness to a murine mammary carcinoma modified to express B7-1, interleukin-12, or GM-CSF.: Cancer Gene Ther. 1997 May-Jun;4(3):157-66. Unique Identifier : AIDSLINE MED/97315942; Aruga E; Aruga A; Arca MJ; Lee WM; Yang NS; Smith JW 2nd; Chang AE; Division of Surgical Oncology, University of Michigan, Ann Arbor, USA.; This report characterizes the immunological host response to a syngeneic murine mammary carcinoma along with variants genetically modified to express B7-1 or secrete GM-CSF and interleukin-12 (IL-12). MT-901 is a subline of a mammary adenocarcinoma that was chemically induced in the Balb/c host. It was found to be wea
[The epidemiology, risk factors and prevention of anal cancer]: Gastroenterol Hepatol. 1997 May;20(5):283-9. Unique Identifier : AIDSLINE MED/97326198; Balague Corbella M; Moreno Aguado V; Bosch Jose FX; Servicio de Epidemiologia y Registro del Cancer, Hospital Duran i; Reynals, L'Hospitalet de Llobregat, Barcelona.
What's in a name? The evolution of universal precautions to standard precautions. A guide to the latest recommendations in isolation practices.: Todays Surg Nurse. 1997 Jan-Feb;19(1):14-21; quiz 46-7. Unique Identifier : AIDSLINE MED/97377642; Garner JS; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; New guidelines are intended to provide infection protection to patients and hospital staff. Many approaches to infection prevention in hospitals have been considered in the past. Guidelines for infection control must be thorough, reasonable to apply, and protective of patients, visitors, and staff.
Lynda's story. Campaigning for health care worker safety [see comments]: Todays Surg Nurse. 1997 Jan-Feb;19(1):48-9. Unique Identifier : AIDSLINE MED/97377649; Arnold LM
Viral RNA export.: Chem Biol. 1997 May;4(5):335-44. Unique Identifier : AIDSLINE MED/97341236; Hope TJ; Salk Institute for Biological Studies 10010 North Torrey Pines Road,; La Jolla, CA 92037, USA.; Viruses can express intron-containing and intronless mRNAs, which are exported by alternative pathways. The study of the nuclear export of these unconventional mRNAs can provide key insights into the normal process of nuclear export and the alternative pathways provide an attractive target for the development of speci
Pathogenic mechanisms of neuronal damage in the AIDS dementia complex.: Mol Pathol. 1997 Apr;50(2):72-6. Unique Identifier : AIDSLINE MED/97374704; Swingler S; Department of Biological Sciences, University of Warwick, Coventry,; United Kingdom.
Researchers in cell motility and the cytoskeleton can play major roles in understanding AIDS.: Cell Motil Cytoskeleton. 1997;37(2):91-7. Unique Identifier : AIDSLINE MED/97329532; Soll DR; Department of Biological Sciences, University of Iowa, Iowa City; 52242, USA.
AIDS-related extrapulmonary Pneumocystis carinii infection presenting as a solitary rectal ulcer.: Can J Gastroenterol. 1996 Oct;10(6):401-4. Unique Identifier : AIDSLINE MED/97337030; Yoshida EM; Filipenko D; Phillips P; Montaner JS; Whittaker JS; Department of Medicine, University of British Columbia, Vancouver.; Extrapulmonary infection with Pneumocystis carinii, although uncommon, is increasingly recognized. Use of aerosolized pentamidine versus a systemic medication is thought to be a contributing factor due to the low concentrations of drug that are incapable of suppressing systemic infection. Infection with P carinii has
Diagnosis and treatment of viral STDs in women.: Int J Fertil Womens Med. 1997 Mar-Apr;42(2):107-14. Unique Identifier : AIDSLINE MED/97303936; Baker DA; Department of Obstetrics, Gynecology & Reproductive Medicine, State; University of New York at Stony Brook, USA.; Viral sexually transmitted diseases (STDs) are a major health problem for women. Over many years the incidence of these infections has increased steadily to epidemic proportions. These infections not only cause short-term morbidity but also have been associated with significant long-term morbidity and mortality. This
[The mRNA expression of CD2, CD4 and CD8 in peripheral blood lymphocytes from the patients with acute lymphoblastic leukemia and non-Hodgkin's lymphoma]: Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 1995 Dec;17(6):403-6. Unique Identifier : AIDSLINE MED/97352283; Zhang Z; Xu C; Liu S; Zheng D; Li S; Institute of Basic Medical Sciences, CAMS, Beijing.; The paper for the first time reports the detection of the levels of CD2, CD4 and CD8 mRNA expression in peripheral blood lymphocytes from 9 cases with T-acute lymphoblastic leukemia ALL) and 10 cases with T- non-Hodgkin s lymphoma (NHL) by using RNA dot blotting technique. It was fo
Occupational exposure to the risk of HIV infection among health care workers in Mwanza Region, United Republic of Tanzania.: Bull World Health Organ. 1997;75(2):133-40. Unique Identifier : AIDSLINE MED/97328864; Gumodoka B; Favot I; Berege ZA; Dolmans WM; Bugando Medical Centre, Mwanza, United Republic of Tanzania.; During 1993, we collected data on knowledge of human immunodeficiency virus (HIV) transmission, availability of equipment, protective practices and the occurrence of prick and splash incidents in nine hospitals in the Mwanza Region in the north-west of the United Republic of Tanzania
Regulation of NF-kappa B and disease control: identification of a novel serine kinase and thioredoxin as effectors for signal transduction pathway for NF-kappa B activation.: Curr Top Cell Regul. 1997;35:149-61. Unique Identifier : AIDSLINE MED/97335513; Okamoto T; Sakurada S; Yang JP; Merin JP; Department of Molecular Genetics, Nagoya City University Medical; School, Japan.; We have identified novel signal transduction cascades in activating NF-kappa B, as well as its pathogenetic roles in various disease processes. By applying the basic knowledge obtained through these studies, we hope to find new therapeutic measures against currently incurable diseases such as hematogenic cancer cell m
The experience of family foster care in Malawi: a preliminary investigation.: Child Welfare. 1997 Jul-Aug;76(4):535-47. Unique Identifier : AIDSLINE MED/97361448; Bandawe CR; Louw J; University of Malawi College of Medicine, Department of Community; Health, Blantyre, Malawi.; This preliminary investigation into family foster care in Malawi set out to provide information on the Malawi government family foster care structure primarily through the qualitative experience of foster caregivers. A semistructured interview schedule was used to interview 24 fost
Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS.: Eur J Pharmacol. 1997 Apr 23;325(1):81-4. Unique Identifier : AIDSLINE MED/97296378; Sei Y; Nishida K; Kustova Y; Markey SP; Morse HC 3rd; Basile AS; Laboratory of Neuroscience, NIDDK, National Institutes of Health,; Bethesda, MD 20892, USA. sei@helix.nih.gov; Tumor necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) have been implicated in the pathogenesis of human immunodeficiency virus (HIV)-associated encephalopathy. The effects of pentoxifylline on brain PAF levels were examined in mice infected with the LP-BM5 murine leukemia virus (MuLV). Seven wee
[The molecular bases of AIDS therapy]: Gac Med Mex. 1997 Mar-Apr;133(2):151-3. Unique Identifier : AIDSLINE MED/97359166; Benitez-Bribiesca L; Unidad de Investigacion en Enfermedades Oncologicas, Hospital de; Oncologia, IMSS, CMN Siglo XXI, Mexico, D.F.
[Concepts on the treatment of patients infected with the human immunodeficiency virus (HIV) (letter)]: Gac Med Mex. 1997 Mar-Apr;133(2):171. Unique Identifier : AIDSLINE MED/97359170; Ruiz Arguelles GJ
[Prevalence of serum anti-hepatitis E virus antibodies in patients with human immunodeficiency virus infection (letter)]: Gastroenterol Clin Biol. 1997;21(5):440. Unique Identifier : AIDSLINE MED/97351745; Tran A; Broussard JF; Durant J; Broussard N; Dellamonica P; Rampal P; Benzaken S
Unusual endoscopic features of gastric and duodenal cryptosporidiosis in AIDS.: Gastrointest Endosc. 1997 Jun;45(6):525-7. Unique Identifier : AIDSLINE MED/97343311; Chalasani N; Lazenby AJ; Wilcox CM; Department of Medicine, Emory University, School of Medicine, Atlanta,; Georgia, USA.
Incidence of apoptosis in HIV-myelopathy, myelodysplastic syndromes and non-specific inflammatory lesions of the bone marrow.: Histopathology. 1997 Apr;30(4):307-11. Unique Identifier : AIDSLINE MED/97292564; Thiele J; Zirbes TK; Wiemers P; Lorenzen J; Kvasnicka HM; Fischer R; Institute of Pathology, University of Cologne, Germany.; Myelodysplastic syndromes, AIDS-related myelopathy and non-specific inflammatory reactions (mostly rheumatoid myelitis) are characterized by normo- to hypercellular bone marrow, but frequently display cytopenias in the peripheral blood. In the current study we have addressed the question whether this situation reflect
Disseminated microsporidiosis in a patient with acquired immunodeficiency syndrome.: Histopathology. 1997 Apr;30(4):386-9. Unique Identifier : AIDSLINE MED/97292581; Cowley GP; Miller RF; Papadaki L; Canning EU; Lucas SB; Department of Histopathology, University College London Medical; School, UK.
Effects of Ixodes scapularis and Borrelia burgdorferi on modulation of the host immune response: induction of a TH2 cytokine response in Lyme disease-susceptible (C3H/HeJ) mice but not in disease-resistant (BALB/c) mice.: Infect Immun. 1997 Aug;65(8):3100-6. Unique Identifier : AIDSLINE MED/97378079; Zeidner N; Mbow ML; Dolan M; Massung R; Baca E; Piesman J; Division of Vector-Borne Infectious Diseases, Centers for Disease; Control and Prevention, Fort Collins, Colorado 80522, USA.; Previous studies have demonstrated that both Ixodes scapularis saliva and Borrelia burgdorferi antigens modulated lymphokines and monokines in vitro. The studies presented here were designed to delineate the role of I. scapularis and B. burgdorferi in modulation of the host immune response in vivo. Infestation of C3H/
Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice.: Infect Immun. 1997 Aug;65(8):3165-70. Unique Identifier : AIDSLINE MED/97378089; Schito ML; Barta JR; Department of Pathobiology, Ontario Veterinary College, University of; Guelph, Canada.; Severe combined immunodeficient (SCID)-beige mice inoculated with the intracellular parasite Eimeria papillata produced significantly more oocysts during primary infections than inoculated immunodeficient SCID mice. Therefore, the addition of the beige mutation, which detrimentally affects neutrophil and natural kille
Pathogenesis of tuberculosis in mice exposed to low and high doses of an environmental mycobacterial saprophyte before infection.: Infect Immun. 1997 Aug;65(8):3317-27. Unique Identifier : AIDSLINE MED/97378112; Hernandez-Pando R; Pavon L; Arriaga K; Orozco H; Madrid-Marina V; Rook G; Department of Pathology, Instituto Nacional de la Nutricion Salvador; Zubiran, Mexico City, Mexico.; Mycobacteria are ubiquitous in the environment, but they are not part of the normal human microbial flora. It has been suggested that variable contact with mycobacteria can influence susceptibility to mycobacterial pathogens and the efficacy of subsequent Mycobacterium bovis BCG vaccination. To test this, mice were im
Conquering AIDS: a long way to go [news]: Int Nurs Rev. 1997 May-Jun;44(3):66. Unique Identifier : AIDSLINE MED/97338689
Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip region of p66. Implications for DNA synthesis and dimerization.: J Biol Chem. 1997 Jul 11;272(28):17581-7. Unique Identifier : AIDSLINE MED/97362248; Wohrl BM; Krebs R; Thrall SH; Le Grice SFJ; Scheidig AJ; Goody RS; Max Planck Institut fur molekulare Physiologie, Abteilung; Physikalische Biochemie, Rheinlanddamm 201, 44139 Dortmund, Germany.; birgit.woehrl@mpi-dortmund.mpg.de; The highly conserved primer grip region in the p66 subunit of HIV-1 reverse transcriptase (RT) is formed by the beta12-beta13 hairpin (residues 227-235). It has been proposed to play a role in aligning the 3 -OH end of the primer in a position for nucleophilic attack on an incoming dNTP. To analyze the importance of t
In vitro chromatin assembly of the HIV-1 promoter. ATP-dependent polar repositioning of nucleosomes by Sp1 and NFkappaB.: J Biol Chem. 1997 Jul 11;272(28):17654-61. Unique Identifier : AIDSLINE MED/97362258; Widlak P; Gaynor RB; Garrard WT; Department of Molecular Biology and Oncology, University of Texas; Southwestern Medical Center, Dallas, Texas 75235-9140, USA.; Nuclease hypersensitive sites exist in vivo in the chromatin of the integrated human immunodeficiency virus (HIV)-1 proviral genome, in the 5 -long terminal repeat (LTR) within the promoter/enhancer region near Sp1 and NFkappaB binding sites. Previous studies from the Kadonaga and Jones laboratories have shown that Sp
Respiratory distress in a former drug abuser.: Hosp Pract (Off Ed). 1997 Jul 15;32(7):141-4. Unique Identifier : AIDSLINE MED/97371438; Muthiah M; Mishriki YY; Pennsylvania State University College of Medicine, Harshey, USA.
HIV risk reduction for the seriously mentally ill: pilot investigation and call for research.: J Behav Ther Exp Psychiatry. 1997 Jun;28(2):87-95. Unique Identifier : AIDSLINE MED/97337263; Weinhardt LS; Carey MP; Carey KB; Department of Psychology, Syracuse University, NY 13244-2340, USA.; Research indicates that people with serious mental illnesses SMI; e.g., schizophrenia, schizoaffective disorder, bipolar disorder) are at enhanced risk for infection with the human immunodeficiency virus (HIV). To decrease this risk, we piloted a six-session HIV-risk reduction intervention for two single-gender groups
Modulation of host cell activation during feline immunodeficiency virus (FIV) infection.: J Comp Pathol. 1997 Apr;116(3):263-71. Unique Identifier : AIDSLINE MED/97292734; Silvotti L; Kramer L; Corradi A; Busani L; Tedeschi F; Brandi G; Bendinelli M; Piedimonte G; Istituto di Anatomia Patologica Veterinaria, Universita di Parma,; Italy.; The authors describe the mitogenic effect of feline immunodeficiency virus (FIV) infection (1) in vitro, on feline resting peripheral blood lymphocytes (PBL), and (2) in vivo, in experimentally infected cats. Infected PBL were more readily recruited than non-infected PBL, into the G1 phase of the cell cycle and showed
Effect of immunosuppression on composition of quasispecies population of hepatitis C virus in patients with chronic hepatitis C coinfected with human immunodeficiency virus.: J Hepatol. 1997 May;26(5):975-82. Unique Identifier : AIDSLINE MED/97330368; Toyoda H; Fukuda Y; Koyama Y; Takamatsu J; Saito H; Hayakawa T; Second Department of Internal Medicine, Nagoya University School of; Medicine, Japan.; BACKGROUND/AIMS: To study the effects of the immunosuppression caused by the reduction of CD4 activity on the composition of hepatitis C virus (HCV) populations, we analyzed the number of HCV quasispecies clones and the nucleotide diversity of the hypervariable region 1 (HVR1) of HCV in 37 patients with hemophilia wit
Management of healthcare workers infected with hepatitis B virus, hepatitis C virus, human immunodeficiency virus, or other bloodborne pathogens. AIDS/TB Committee of the Society for Healthcare Epidemiology of America.: Infect Control Hosp Epidemiol. 1997 May;18(5):349-63. Unique Identifier : AIDSLINE MED/97299079; This article provides the current recommendations of the Society for Healthcare Epidemiology of America (SHEA) regarding the management of healthcare workers infected with hepatitis B virus HBV), hepatitis C virus (HCV), or the human immunodeficiency virus (HIV). For the reasons cited in the article, SHEA now maintain
Frontiers of occupational health. New vaccines, new prophylactic regimens, and management of the HIV-infected worker.: Infect Dis Clin North Am. 1997 Jun;11(2):313-29. Unique Identifier : AIDSLINE MED/97331617; Beekmann SE; Doebbeling BN; Department of Internal Medicine, University of Iowa College of; Medicine, Iowa City, USA.; New prophylactic or treatment options are available for a number of infectious diseases that may be transmitted in the health care setting. Infectious diseases that can now be prevented by vaccination of the employee include hepatitis A, pertussis, hepatitis B, and primary varicella. New prophylactic or treatment regi
Bloodborne pathogen transmission in health care workers. Risks and prevention strategies.: Infect Dis Clin North Am. 1997 Jun;11(2):331-46. Unique Identifier : AIDSLINE MED/97331618; Cardo DM; Bell DM; HIV Infections Branch, Hospital Infections Program, National Center; for Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, Georgia, USA.; Occupational transmission of hepatitis B virus (HBV), hepatitis C virus, and HIV has been documented. The risk for occupationally transmitted infection varies for these three viruses. Despite effective pre- and postexposure prophylaxis for HBV and recent recommendations for postexposure chemoprophylaxis after an HIV e
Prevention of nosocomial transmission of Mycobacterium tuberculosis.: Infect Dis Clin North Am. 1997 Jun;11(2):385-409. Unique Identifier : AIDSLINE MED/97331621; Cookson ST; Jarvis WR; Investigation and Prevention Branch, Hospital Infections Program,; National Center for Infectious Diseases, Centers for Disease Control; and Prevention, Atlanta, Georgia, USA.; The recent resurgence of TB together with the ongoing HIV epidemic has resulted in a larger number of infectious TB patients being admitted to US health care facilities. These patients have become a source for both nosocomial patient-to-patient) and occupational (patient-to-health care worker) M. tuberculosis transmis
Correction of defective expression in MHC class II deficiency bare lymphocyte syndrome) cells by retroviral transduction of CIITA.: J Immunol. 1997 Aug 1;159(3):1086-95. Unique Identifier : AIDSLINE MED/97376830; Bradley MB; Fernandez JM; Ungers G; Diaz-Barrientos T; Steimle V; Mach B; O'Reilly R; Lee JS; Sloan-Kettering Institute, Department of Pediatrics, Memorial; Sloan-Kettering Cancer Center, New York 10021, USA.; Retrovirus-mediated gene transfer was used to restore expression to MHC class II-negative patient cells from complementation group A(II) of MHC class II immunodeficiency or bare lymphocyte syndrome (BLS). The cells of these patients do not transcribe MHC class II genes due to a defect in the trans-acting factor, CIITA
The effects of IFN-gamma on CD40-mediated activation of B cells from X-linked immunodeficient or normal mice.: J Immunol. 1997 Aug 1;159(3):1150-9. Unique Identifier : AIDSLINE MED/97376837; Johnson-Leger C; Hasbold J; Holman M; Klaus GG; Division of Cellular Immunology, National Institute for Medical; Research, London, United Kingdom.; B cell activation induced by cross-linking of CD40 is enhanced by costimulation with certain T cell-derived cytokines (generally Th2 type), most notably IL-4. We show here that the induction of DNA synthesis in normal mouse B cells by anti-CD40 mAb is also significantly enhanced by supernatants from anti-CD3-activated
Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype.: J Immunol. 1997 Aug 1;159(3):1160-8. Unique Identifier : AIDSLINE MED/97376838; Sloan-Lancaster J; Steinberg TH; Allen PM; Cell Biology and Metabolism Branch, National Institute of Child Health; and Development, Bethesda, MD 20892, USA.; In the CD4+ T cell lineage, two well-defined differentiated populations are the Th1 and Th2 cells, which stem from a common naive T helper precursor (Thp). In this study, we begin to dissect the signaling pathways selectively used by Th1 or Th2 cells as they mature from a common naive precursor in vitro. We show that
Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease.: J Immunol. 1997 Aug 1;159(3):1208-15. Unique Identifier : AIDSLINE MED/97376844; Williamson E; Garside P; Bradley JA; More IA; Mowat AM; Department of Immunology, University of Glasgow, Scotland.; Injection of parental spleen cells into BDF1 mice results in a graft-vs-host disease (GVHD), the nature of which is critically dependent on the parental haplotype. B6-->BDF1 mice develop a Th1-mediated immunosuppressive lethal GVHD, whereas DBA/2-->BDF1 mice develop a Th2-dependent chronic GVHD, characterized by autoa
Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens.: J Immunol. 1997 Aug 1;159(3):1328-35. Unique Identifier : AIDSLINE MED/97376858; Garcia VE; Sieling PA; Gong J; Barnes PF; Uyemura K; Tanaka Y; Bloom BR; Morita CT; Modlin RL; Division of Dermatology, University of California Los Angeles School; of Medicine, 90095, USA.; TCR gamma delta T cells are considered important in the rapid immune response to intracellular infection. We investigated the early response of peripheral blood gamma delta T cells to the nonpeptide Ag isopentenyl pyrophosphate and to its synthetic analogue ethyl pyrophosphate. In healthy donors, an increase in the nu
Immunodominance of a single CTL epitope in a primate species with limited MHC class I polymorphism.: J Immunol. 1997 Aug 1;159(3):1374-82. Unique Identifier : AIDSLINE MED/97376863; Evans DT; Piekarczyk MS; Allen TM; Boyson JE; Yeager M; Hughes AL; Gotch FM; Hinshaw VS; Watkins DI; Wisconsin Regional Primate Research Center, University of Wisconsin,; Madison 53715, USA.; MHC class I molecules play a crucial role in immunity to viral infections by presenting viral peptides to cytotoxic T lymphocytes. One of the hallmarks of MHC class I genes in outbred populations is their extraordinary polymorphism, yet the significance of this diversity is poorly understood. Certain species with redu
Differential effects of the T helper cell type 2-derived cytokines IL-4 and IL-5 on ligand binding to IgG and IgA receptors expressed by human eosinophils.: J Immunol. 1997 Aug 1;159(3):1459-65. Unique Identifier : AIDSLINE MED/97376873; Bracke M; Dubois GR; Bolt K; Bruijnzeel PL; Vaerman JP; Lammers JW; Koenderman L; Department of Pulmonary Diseases, University Hospital Utrecht, The; Netherlands.; Increased numbers of eosinophilic granulocytes that exhibit an activated phenotype are found in bronchial tissue and bronchial alveolar lavage fluid of patients with allergic asthma. Little is known about the processes that lead to activation of eosinophils in vivo, but Igs might be important stimulants. In the presen
In vivo IL-12 administration induces profound but transient commitment to T helper cell type 1-associated patterns of cytokine and antibody production.: J Immunol. 1997 Aug 1;159(3):1490-6. Unique Identifier : AIDSLINE MED/97376877; Rempel JD; Wang M; HayGlass KT; Department of Immunology, University of Manitoba, Winnipeg, Canada.; There is much interest in the utility of exogenous IL-12 as a biologic adjuvant in immediate hypersensitivity and infectious or parasitic diseases where the induction of Th1 responses is strongly associated with protective immunity. Using an immediate hypersensitivity model in which C57Bl/6 mice immunized with OVA alu
Characterization of thyroglobulin-directed and polyreactive catalytic antibodies in autoimmune disease.: J Immunol. 1997 Aug 1;159(3):1530-6. Unique Identifier : AIDSLINE MED/97376881; Paul S; Li L; Kalaga R; O'Dell J; Dannenbring RE Jr; Swindells S; Hinrichs S; Caturegli P; Rose NR; Department of Anesthesiology, Eppley Cancer Research Institute,; University of Nebraska Medical Center, Omaha 68198, USA.; spaul@mail.unmc.edu; Polyreactive and thyroglobulin (Tg)-directed proteolytic activities present in the serum IgG of healthy controls and patients with autoimmune disease were studied by electrophoretic separation of 125I-labeled Tg reaction products and spectrofluorometric measurement of Pro-Phe-Arg-methylcoumarinamide cleavage at the Ar
HIV genetic variation: clinical importance.: J Infect. 1997 May;34(3):195-9. Unique Identifier : AIDSLINE MED/97343468; Lever AM; University of Cambridge Department of Medicine, Addenbrooke's; Hospital, U.K.
HIV genetic variation: life at the edge.: J Infect. 1997 May;34(3):201-3. Unique Identifier : AIDSLINE MED/97343469; Pezo V; Wain-Hobson S; Unite de Retrovirologie Moleculare, Institut Pasteur, Paris, France.
Haemophagocytic syndrome in patients infected with the human immunodeficiency virus: nine cases and a review.: J Infect. 1997 May;34(3):219-25. Unique Identifier : AIDSLINE MED/97343473; Grateau G; Bachmeyer C; Blanche P; Jouanne M; Tulliez M; Galland C; Sicard D; Sereni D; Service de Medecine Interne, Hotel-Dieu, Paris, France.; We report nine cases of haemophagocytic syndrome (HS) in patients with human immunodeficiency virus infection, and review the 17 cases described to date in the literature. In 21 of 26 cases, HS developed during an advanced stage of immunodeficiency. Clinical and haematological signs are not specific in this setting, a
Hepatic pneumocystosis without concomitant PCP in a patient with AIDS.: J Infect. 1997 May;34(3):257-9. Unique Identifier : AIDSLINE MED/97343478; Sarmento e Castro R; Vasconcelos O; Carneiro F; Rocha-Marques A; Infectious Diseases Department, Hospital de Joaquim Urbano, Porto,; Portugal.
Bilateral facial palsy secondary to herpes zoster meningoencephalitis in a HIV-positive woman.: J Infect. 1997 May;34(3):261-2. Unique Identifier : AIDSLINE MED/97343479; Mahadeen ZI; Brennan RW; Kothari MJ; Division of Neurology, Pennsylvania State University, College of; Medicine, Hershey 17033, USA.; Bilateral facial paralysis of diverse infectious aetiologies has been reported in HIV infected patients. We present a patient with bilateral facial palsy most likely due to herpes zoster meningoencephalitis in a patient with neutropenia and who subsequently tested HIV-positive.
Development of novel influenza virus vaccines and vectors.: J Infect Dis. 1997 Aug;176 Suppl 1:S45-9. Unique Identifier : AIDSLINE MED/97382690; Palese P; Zavala F; Muster T; Nussenzweig RS; Garcia-Sastre A; Department of Microbiology, Mount Sinai School of Medicine, New York,; New York 10029, USA.; Approaches to improve the efficacy of the current (killed) influenza virus vaccines include the generation of cold-adapted and genetically engineered influenza viruses containing specific attenuating mutations. It is hoped that these genetically altered viruses, in which the hemagglutinin and neuraminidase genes from
B cell superantigens: potential modifiers of the normal human B cell repertoire.: Int Rev Immunol. 1997;14(4):309-24. Unique Identifier : AIDSLINE MED/97330324; Domiati-Saad R; Lipsky PE; Department of Internal Medicine, University of Texas Southwestern; Medical Center at Dallas 75235, USA.; Staphylococcal protein A (SPA), HIV gp120, and staphylococcal enterotoxins (SE) are B cell superantigens that induce VH specific B cell responses. In addition, the red blood cell antigens, i/I, have some features of a B cell superantigen. Binding of SPA, SE and HIV gp120 are VH family specific, whereas binding of i/I
HIV-1 gp120: a novel viral B cell superantigen.: Int Rev Immunol. 1997;14(4):325-38. Unique Identifier : AIDSLINE MED/97330325; Townsley-Fuchs J; Neshat MS; Margolin DH; Braun J; Goodglick L; Department of Pathology, University of California, Los Angeles; 90095-1732, USA.; The envelope glycoprotein of the human immunodeficiency virus HIV-1), gp120, has recently been characterized as a novel immunoglobulin superantigen (Ig-SAg) [1,2]. Analogous to the interaction of SAgs with T cells, gp120 binds to an unusually large proportion of immunoglobulins (lgs) from HIV-uninfected individuals; m
B cell superantigens in HIV-1 infection.: Int Rev Immunol. 1997;14(4):339-49. Unique Identifier : AIDSLINE MED/97330326; Muller S; Kohler H; Markey Cancer Center, University of Kentucky, Lexington 40536, USA.; HIV-I infection affects many of the cellular components vital for the maintenance of immune homeostasis. Similar to the T cell superantigen effect on T cell expansion and depletion in AIDS. HIV components with B cell superantigenic properties could be responsible for the observed B cell activation and skewing of VH fa
Ig VH-dependent interaction between immunoglobulins and CD4.: Int Rev Immunol. 1997;14(4):351-62. Unique Identifier : AIDSLINE MED/97330327; Lenert P; Lenert G; Zanetti M; Louis-Charles Simard Research Center, Notre-Dame Hospital, University; of Montreal, Quebec, Canada.; CD4 interacts with the immunoglobulin (Ig)-VH domains by a virtue of its solvent-exposed C and C strands. These two strands also contribute to the full HIV-gp120 binding and participate significantly in binding to class II MHC molecules. In this paper we hypothesize that any high-affinity interaction between serum or
Aspergillus mastoiditis in a patient with acquired immunodeficiency syndrome.: J Laryngol Otol. 1997 Jun;111(6):560-1. Unique Identifier : AIDSLINE MED/97374643; Yates PD; Upile T; Axon PR; de Carpentier J; Department of Otolaryngology, Manchester Royal Infirmary, UK.; We present the case history of a patient who was severely immunocompromised due to infection with the human immunodeficiency virus (HIV), and who subsequently developed acute mastoiditis due to Aspergillus fumigatus. Fungal otomastoiditis is a rarely reported complication of HIV infection. A high index of suspicion is
Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells.: J Exp Med. 1997 Jul 21;186(2):239-45. Unique Identifier : AIDSLINE MED/97368210; Kurts C; Kosaka H; Carbone FR; Miller JF; Heath WR; Thymus Biology Unit, The Walter and Eliza Hall Institute of Medical; Research, Royal Melbourne Hospital, Parkville 3050, Victoria,; Australia.; In this report, we show that cross-presentation of self-antigens can lead to the peripheral deletion of autoreactive CD8(+) T cells. We had previously shown that transfer of ovalbumin OVA)-specific CD8(+) T cells (OT-I cells) into rat insulin promoter-membrane-bound form of OVA transgenic mice, which express the model
T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice.: J Exp Med. 1997 Jul 21;186(2):299-306. Unique Identifier : AIDSLINE MED/97368216; Pakala SV; Kurrer MO; Katz JD; Department of Pathology and Center for Immunology, Washington; University School of Medicine, St. Louis, Missouri 63110, USA.; Autoimmune diabetes is caused by the CD4(+), T helper 1 (Th1) cell-mediated apoptosis of insulin-producing beta cells. We have previously shown that Th2 T cells bearing the same T cell receptor (TCR) as the diabetogenic Th1 T cells invade islets in neonatal nonobese diabetic (NOD) mice but fail to cause disease. Moreo
Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease.: J Exp Med. 1997 Jul 21;186(2):307-12. Unique Identifier : AIDSLINE MED/97368217; Lafaille JJ; Keere FV; Hsu AL; Baron JL; Haas W; Raine CS; Tonegawa S; Howard Hughes Medical Institute, Center for Cancer Research, and; Department of Biology, Massachusetts Institute of Technology,; Cambridge, Massachusetts 02139, USA.; Chronic inflammatory autoimmune diseases such as multiple sclerosis, diabetes, and rheumatoid arthritis are caused by CD4(+) Th1 cells. Because Th2 cells antagonize Th1 cell functions in several ways, it is believed that immune deviation towards Th2 can prevent or cure autoimmune diseases. Experimental autoimmune ence
Structure and genomic organization of a novel human endogenous retrovirus family: HERV-K (HML-6).: J Gen Virol. 1997 Jul;78 ( Pt 7):1731-44. Unique Identifier : AIDSLINE MED/97368436; Medstrand P; Mager DL; Yin H; Dietrich U; Blomberg J; Department of Medical Microbiology, Lund University, Sweden.; Patrik.Medstrand@mmb.lu.se; Prototypic elements of a novel human endogenous retrovirus (HERV) family were identified and cloned from a human genomic library by the use of a pol fragment, HML-6, related to type A and type B retroviruses and class II HERVs. Out of 39 polhybridizing clones, five contained structures of full-length retroviral provir
Transfer of endoplasmic reticulum and Golgi retention signals to human immunodeficiency virus type 1 gp160 inhibits intracellular transport and proteolytic processing of viral glycoprotein but does not influence the cellular site of virus particle budding.: J Gen Virol. 1997 Jul;78 ( Pt 7):1745-53. Unique Identifier : AIDSLINE MED/97368437; Pfeiffer T; Zentgraf H; Freyaldenhoven B; Bosch V; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.; In this study, specific signals known to mediate endoplasmic reticulum or Golgi localization of transmembrane proteins have been transferred to the human immunodeficiency virus type 1 HIV-1) env gene product. The intracellularly retained recombinant glycoproteins were not proteolytically processed to gp120 and gp41, w
Treatment of HIV-related psychotic disorders with risperidone: a series of 21 cases.: J Psychosom Res. 1997 May;42(5):489-93. Unique Identifier : AIDSLINE MED/97337281; Singh AN; Golledge H; Catalan J; Psychological Medicine Unit, South Kensington & Chelsea Mental Health; Centre, London, UK.; We describe a consecutive series of 21 patients with HIV or AIDS who received risperidone for psychotic disorders. Of these, 13 became symptom-free, 7 showed substantial improvement, and 1 had no response. Most responded to low doses of risperidone (mean maximum dose 3.3 mg) and needed only a short course of treatment
Evidence for reduced Th1 function in normal pregnancy: a hypothesis for the remission of rheumatoid arthritis.: J Rheumatol. 1997 Jun;24(6):1045-50. Unique Identifier : AIDSLINE MED/97338947; Russell AS; Johnston C; Chew C; Maksymowych WP; Heritage Medical Research Centre, University of Alberta, Edmonton,; Canada.; OBJECTIVE: The mechanisms underlying the pregnancy induced remission of rheumatoid arthritis (RA) remain unclear. We assessed the hypothesis that it reflects systemic physiologic changes in immune response during gestation. METHODS: We used in vitro whole blood culture systems stimulated with either lipopolysaccharide
Recognition of tissue cyst-specific antigens in reactivating toxoplasmosis.: J Med Microbiol. 1997 Jul;46(7):587-95. Unique Identifier : AIDSLINE MED/97379944; McHugh TD; Bathgate T; Mangan J; Johnson JD; Holliman RE; Butcher PD; Department of Medical Microbiology, Royal Free Hospital School of; Medicine, London.; Current serological tests do not discriminate between asymptomatic latent Toxoplasma gondii infection and reactivating toxoplasmosis, but timely therapeutic intervention before the development of symptoms would lead to major reductions in morbidity and permanent disability. This study developed a new enzyme-linked imm
Evaluation of different techniques in the diagnosis of Toxoplasma encephalitis.: J Med Microbiol. 1997 Jul;46(7):597-601. Unique Identifier : AIDSLINE MED/97379945; Rodriguez JC; Martinez MM; Martinez AR; Royo G; Laboratory of Microbiology, General University, Hospital of Elche,; University of Alicante, Spain.; This study evaluated the detection of antibodies, circulating antigens and parasite DNA by polymerase chain reaction (PCR) in the diagnosis of toxoplasma encephalitis. The detection of antibody classes and IgG avidity were not useful diagnostically. The detection of circulating antigens by the ELISA system described w
Structure of a DNA analog of the primer for HIV-1 RT second strand synthesis.: J Mol Biol. 1997 Jun 27;269(5):811-26. Unique Identifier : AIDSLINE MED/97366813; Han GW; Kopka ML; Cascio D; Grzeskowiak K; Dickerson RE; Molecular Biology Institute, University of California at Los Angeles,; 90095, USA.; The non-self-complementary DNA decamer C-A-A-A-G-A-A-A-A-G/C-T-T-T-T-C-T-T-T-G is a DNA/DNA analogue of a portion of the polypurine tract or PPT, which is a RNA/DNA hybrid that serves as a primer for synthesis of the (+) DNA strand by HIV reverse transcriptase (RT), and which is not digested by the RNase H domain of r
From the Food and Drug Administration.: JAMA. 1997 Aug 6;278(5):379. Unique Identifier : AIDSLINE MED/97386469; Nightingale SL
Global burden of disease [letter; comment]: Lancet. 1997 Jul 12;350(9071):141-2; discussion 144-5. Unique Identifier : AIDSLINE MED/97372925; Schwartlander B
Microorganisms in chronic arthritis [letter; comment]: Lancet. 1997 Jul 12;350(9071):145. Unique Identifier : AIDSLINE MED/97372932; Hasunuma T; Nishioka K; Nishioka K
Inclusion of women in clinical trials of antiretroviral agents for HIV/AIDS during pregnancy [letter]: Lancet. 1997 Jul 12;350(9071):150. Unique Identifier : AIDSLINE MED/97372943; Mangino JE; Fass RJ
Why tyrosinase for treatment of melanoma.: Lancet. 1997 Jul 12;350(9071):82-3. Unique Identifier : AIDSLINE MED/97372901; Song YH; Department of Pathology, Immunology, and Laboratory Medicine,; University of Florida, Gainesville 32610-0275, USA.
Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein.: Mol Pharmacol. 1997 Jul;52(1):98-104. Unique Identifier : AIDSLINE MED/97368051; Este JA; Schols D; De Vreese K; Van Laethem K; Vandamme AM; Desmyter J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium. jaeste@ns.hugtip.scs.es; Polyanionic compounds are known to inhibit the binding of human immunodeficiency virus (HIV) to CD4+ cells and the subsequent fusion step between the virus and cells. We selected an HIV-1 strain resistant to dextran sulfate (DS) by cultivation of HIV-1 NL4-3)-infected MT-4 cells in the presence of DS Mr 5000. DS did n
Postexposure treatment of HIV [letter; comment]: N Engl J Med. 1997 Aug 14;337(7):499-500; discussion 501. Unique Identifier : AIDSLINE MED/97382712; Li RW; Wong JB
Postexposure treatment of HIV [letter; comment]: N Engl J Med. 1997 Aug 14;337(7):500-1. Unique Identifier : AIDSLINE MED/97382713; Pinkerton SD; Holtgrave DR; Bloom FR
Are advances in treatment changing views about high-risk sex? [letter]: N Engl J Med. 1997 Aug 14;337(7):501-2. Unique Identifier : AIDSLINE MED/97382714; Dilley JW; Woods WJ; McFarland W
Murine Th1 clone defines a 60 kD tachyzoite antigen of Toxoplasma gondii.: Parasite Immunol. 1997 May;19(5):229-34. Unique Identifier : AIDSLINE MED/97337360; Reichmann G; Dlugonska H; Fischer HG; Institute for Medical Microbiology and Virology,; Heinrich-Heine-University, Dusseldorf, Germany.; Toxoplasma gondii-specific murine CD4+ T cell clone 3Tx9 belongs to the Th1 subtype by virtue of secreting high levels of interleukin(IL)-2, interferon-gamma and tumor necrosis factor without producing IL4 and IL10. To characterize the clonal antigen, Toxoplasma lysate-was separated by SDS-PAGE and probed in T cell bl
To screen or not to screen for HIV in pregnant women. Pros and cons of routine screening and use of home test kits.: Postgrad Med. 1997 Jul;102(1):77-8, 83-6, 89-90. Unique Identifier : AIDSLINE MED/97367778; Wong JG; Washington University School of Medicine, St Louis, MO 63110, USA.; wong@osler.wustl.edu; Emotions run high when it comes to who should and who should not be tested for HIV. Now, as the debate heats up over screening of all pregnant women and their babies, primary care physicians may find themselves caught in the fray. Recent approval of home HIV test kits allows patients to test themselves, but can the re
[Lymph node cryptococcosis in an AIDS patient on long-term fluconazole: relapse or cure? (letter)]: Presse Med. 1997 Jun 28;26(22):1049. Unique Identifier : AIDSLINE MED/97388899; Ginsburg C; Aaron L; Lesueur A; Salmon-Ceron D; Sicard D
[Aspergillus niger osteitis of the middle ear in a patient with HIV infection (letter)]: Presse Med. 1997 Jul 5;26(23):1098. Unique Identifier : AIDSLINE MED/97388885; Lesueur A; Salmon Ceron D; Corlieu P; Ginsburg C; Sicard D
[Impact of AIDS on admissions and mortality in an Internal Medicine Department (1990-1995)]: Rev Clin Esp. 1997 Apr;197(4):225-31. Unique Identifier : AIDSLINE MED/97340674; del Rio Fernandez MC; Fernandez Renedo A; de Frutos Arribas JF; Sanchez Gonzalez C; Martin Escudero JC; Martinez Barrero F; Servicio de Medicina Interna, Hospital del Rio Hortega, Valladolid.; OBJECTIVE: To know and analyze the main causes of death in an Internal Medicine Department (MI), as well as the impact of AIDS on admissions and mortality rate in such a Department. MATERIALS AND METHODS: A total of 275 patients out of the 35,521 attended patients from 1990 to 1995 had positive serology to HIV (HIV+).
[Polymicrobial endocarditis: a clinical and evolutive study of 12 cases diagnosed during a 10-year period]: Rev Clin Esp. 1997 Apr;197(4):245-7. Unique Identifier : AIDSLINE MED/97340678; Valencia Ortega ME; Enriquez Crego A; Guinea Esquerdo J; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, Centro de Investigacion Clinica,; Instituto de Salud Carlos III, Madrid.; Polymicrobial endocarditis (PE) is uncommon, whether in series of cases of polymicrobial bacteriemia or of endocarditis. Among the 201 cases of infective endocarditis seen between 1986 and 1995 by an infectious diseases service, 12 patients had PE (6%). Nine were males, mean age was 28 years and ten were active intrav
[Nodal nocardiosis in 2 patients with HIV infection treated with cotrimoxazole (letter)]: Rev Clin Esp. 1997 Apr;197(4):298-9. Unique Identifier : AIDSLINE MED/97340690; Valencia Ortega ME; Enriquez Crego A; Adrados de Llano M; Moreno Celda V
Modulation of T-helper cell populations: potential mechanisms of respiratory hypersensitivity and immune suppression.: Toxicol Appl Pharmacol. 1997 Jul;145(1):218-29. Unique Identifier : AIDSLINE MED/97364891; Selgrade MK; Lawrence DA; Ullrich SE; Gilmour MI; Schuyler MR; Kimber I; National Health and Environmental Effects Research Laboratory, U.S.; Environmental Protection Agency, Research Triangle Park, North; Carolina 27711, USA.; Information presented at this symposium indicates that modulation of Th cell responses is one means by which xenobiotics may cause immunotoxicity. A shift from Th1 to Th2 responses can enhance both infectious and allergic disease. Hence, in some cases, a common mechanism may be responsible for effects that are general
Tuberculous lymphadenitis, a diagnostic problem in areas of high prevalence of HIV and tuberculosis.: Trans R Soc Trop Med Hyg. 1997 May-Jun;91(3):294-7. Unique Identifier : AIDSLINE MED/97374751; Bekedam HJ; Boeree M; Kamenya A; Liomba G; Ngwira B; Subramanyam VR; Harries AD; Regional Health Office, Blantyre, Malawi.; The human immunodeficiency virus (HIV) epidemic is associated with a marked increase of tuberculosis cases. The influence of HIV on diagnostic methods for tuberculous lymphadenitis is less clear. In an environment of high HIV and tuberculosis prevalence in Blantyre, Malawi , a prosp
Latex agglutination test for visceral leishmaniasis [letter]: Trans R Soc Trop Med Hyg. 1997 May-Jun;91(3):366. Unique Identifier : AIDSLINE MED/97394203; Arya SC
Tissue-specific characteristics of cytotoxic graft-infiltrating T cells during renal allograft rejection.: Transplantation. 1997 Jul 15;64(1):178-81. Unique Identifier : AIDSLINE MED/97376953; Deckers JG; Boonstra JG; Van der Kooij SW; Daha MR; Van der Woude FJ; Department of Nephrology, Leiden University Hospital, The Netherlands.; BACKGROUND: The alloresponse after renal transplantation was studied using alloreactive T cells generated in vivo (from renal biopsies) and in vitro (from mixed kidney lymphocyte cultures). METHODS: Tissue specificity of graft-infiltrating T cells (GIC) was investigated using donor-derived proximal tubular epithelial
Clinical presentation of pulmonary tuberculosis in under 10s and differences in AIDS-related cases: a cohort study of 115 patients.: Trop Doct. 1997 Jul;27(3):139-42. Unique Identifier : AIDSLINE MED/97370719; Garay JE; St Anne's Hospital, Brunapeg, Matabeleland South, Zimbabwe.; One hundred and fifteen cases of pulmonary tuberculosis (PTB) in children under 10 were reviewed, including a case-control retrospective study between HIV positive (+ve) and HIV negative ve) children. Overall, respiratory symptoms not responding to acute respiratory infection (ARI) protocol and > 10% weight loss or fa
Kinetics of cytokine mRNA expression in the central nervous system following lethal and nonlethal coronavirus-induced acute encephalomyelitis.: Virology. 1997 Jul 7;233(2):260-70. Unique Identifier : AIDSLINE MED/97360022; Parra B; Hinton DR; Lin MT; Cua DJ; Stohlman SA; Department of Molecular Microbiology and Immunology, University of; Southern California School of Medicine, Los Angeles 90033, USA.; The potential role(s) of cytokines in the reduction of infectious virus and persistent viral infection in the central nervous system was examined by determining the kinetics of cytokine mRNA expression following infection with the neurotropic JHM strain of mouse hepatitis virus. Mice were infected with an antibody esc
Ultrastructure of HIV-1 genomic RNA.: Virology. 1997 Jul 7;233(2):271-9. Unique Identifier : AIDSLINE MED/97360023; Hoglund S; Ohagen A; Goncalves J; Panganiban AT; Gabuzda D; Department of Biochemistry, Biomedical Center, Uppsala, Sweden.; stefan.hoglund@biokem.uu.se; The HIV-1 RNA genome is a dimer which consists of two identical strands of RNA linked near their 5 ends by a dimer linkage structure (DLS). We have structurally characterized full-length HIV-1 genomic RNA isolated from HIV-1 virions by electron microscopy. As in other retroviruses, the HIV-1 RNA genome contains a cen
A human IgG1 (b12) specific for the CD4 binding site of HIV-1 neutralizes by inhibiting the virus fusion entry process, but b12 Fab neutralizes by inhibiting a postfusion event.: Virology. 1997 Jul 7;233(2):313-26. Unique Identifier : AIDSLINE MED/97360027; McInerney TL; McLain L; Armstrong SJ; Dimmock NJ; Department of Biological Sciences, University of Warwick, Coventry,; United Kingdom.; The human b12 IgG1, specific for the CD4 binding site of the gp120 of HIV-1, was prepared by recombinant DNA technology. It had a high neutralization rate constant (-3.5 x 10(5) M(-1) sec(-1)), although this is about 10-fold less than the values for the best poliovirus or influenza A virus MAbs. The recombinant b12 Fa
Bovine immunodeficiency virus tat gene: cloning of two distinct cDNAs and identification, characterization, and immunolocalization of the tat gene products.: Virology. 1997 Jul 7;233(2):339-57. Unique Identifier : AIDSLINE MED/97360029; Fong SE; Greenwood JD; Williamson JC; Derse D; Pallansch LA; Copeland T; Rasmussen L; Mentzer A; Nagashima K; Tobin G; Gonda MA; Laboratory of Cell and Molecular Structure, SAIC Frederick,; NCI-Frederick Cancer Research and Development Center, Maryland; 21702-1201, USA. Fong@mail.ncifcrf.gov; cDNAs encoding the bovine immunodeficiency virus (BIV) transactivator gene (tat) were cloned from virally infected cells and characterized. BIV expresses two distinct tat mRNAs composed of three exons that are derived by alternative splicing. The BIV tat mRNA splice variants encode Tat proteins of 103 (Tat103) and 108
Modulation of stress protein (hsp27 and hsp70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type-1.: Virology. 1997 Jul 7;233(2):364-73. Unique Identifier : AIDSLINE MED/97360031; Wainberg Z; Oliveira M; Lerner S; Tao Y; Brenner BG; McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital,; Montreal, Quebec, Canada.; This study was designed to assess the impact of acute human immunodeficiency virus (HIV-1) infection on host intracellular expression of the heat shock family of stress proteins (hsps). Experimental conditions were established wherein CD4+ lymphocytic cell lines undergo a synchronous HIV-1 infection cycle. During the
Unique sequence and lesional tropism of a new variant of neuropathogenic friend murine leukemia virus.: Virology. 1997 Jul 7;233(2):411-22. Unique Identifier : AIDSLINE MED/97360036; Takase-Yoden S; Watanabe R; Institute of Life Science, Soka University, Hachioji, Tokyo, Japan.; takase@scc1.t.soka.ac.jp; FrC6 murine leukemia virus (MuLV) is a replication-competent, neuropathogenic variant derived from Friend MuLV (F-MuLV) complex. The A8 virus (a molecular clone of the FrC6 virus) induced marked spongiform degeneration in the brain similar to the FrC6 virus, but only mild lesions were found in the spinal cord. In cont
Antiretroviral therapy for human immunodeficiency virus infection in 1997.: West J Med. 1997 May;166(5):319-25. Unique Identifier : AIDSLINE MED/97360425; Katzenstein DA; Center for AIDS Research, Stanford University, California, USA.; It has become clear that the acquired immunodeficiency syndrome follows continuous replication of the human immunodeficiency virus (HIV) and a decrease in immune capability, most obviously a decline in the number of CD4 lymphocytes. An understanding of key elements in the infectious life cycle of HIV has led to the de
Self-association of truncated forms of HIV-1 gp120.: Virus Res. 1997 Jun;49(2):163-72. Unique Identifier : AIDSLINE MED/97356959; Malvoisin E; Kieny MP; Wild F; INSERM Unit 404, Institut Pasteur de Lyon, France.; HIV-1 gp120 and truncated forms were expressed in HeLa T4 cells by vaccinia recombinant viruses. The truncated gp120 molecules consisted of N-terminal overlapping envelope proteins of 204, 287 and 393 amino acids respectively. Immunoprecipitation with specific monoclonal antibodies and SDS-PAGE analyses of HIV-1 gp120
Simian immunodeficiency viruses containing mutations in the long terminal repeat NF-kappa B or Sp1 binding sites replicate efficiently in T cells and PHA-stimulated PBMCs.: Virus Res. 1997 Jun;49(2):205-13. Unique Identifier : AIDSLINE MED/97356963; Zhang J; Novembre F; Rabson AB; New Jersey Center for Advanced Biotechnology and Medicine (CABM),; University of Medicine and Dentistry of New Jersey, Robert Wood; Johnson Medical School, Piscataway, USA.; The long terminal repeats (LTRs) of primate lentiviruses contain conserved binding sites for the NF-kappa B and Sp1 cellular transcription factors. In order to study the role that these sites play in simian immunodeficiency virus (SIV) replication, we have introduced mutations that disrupt either the NF-kappa B or Sp1
Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin.: Virus Res. 1997 Jun;49(2):215-23. Unique Identifier : AIDSLINE MED/97356964; Hecker C; Weise C; Schneider-Schaulies J; Holmes HC; ter Meulen V; Institut fur Virologie und Immunbiologie, Wurzburg, Germany.; The observation that HIV in vitro can infect CD4- and Gal-C-negative brain cell lines has stimulated this study to identify alternative gp120-binding proteins on brain cells. HIV-1 gp120 binding proteins of the CD4-negative and Gal-C-negative, non-productively infectable human glioblastoma cell line D54 were purified
Incidence of visible and occult blood on laryngoscope blades and handles.: AANA J. 1997 Jun;65(3):241-6. Unique Identifier : AIDSLINE MED/97377398; Phillips RA; Monaghan WP; University of Southern Mississippi, Long Beach, USA.; Anesthesia providers must take appropriate precautions to reduce the potential for transmission of infectious agents to the patients under their care. The devastating spread of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) over the past decade has resulted in the development of specific guidelines for
Stable transfection of provirus of human immunodeficiency virus into a murine packaging cell line.: Acta Virol. 1997 Apr;41(2):105-10. Unique Identifier : AIDSLINE MED/97363348; Rozera C; Baccarini S; Gentile M; Torrisi MR; Proietti E; Federico M; Pulciani S; Istituto Superiore di Sanita, Laboratorio di Virologia, Roma, Italy.; In order to generate HIV (murine leukemia virus (MuLV)) pseudotypes, HIV genome was transfected into the ecotropic murine packaging cell line (GP+E86) and four of the nine transfected clones were extensively characterized. One clone (801), harbouring a full copy of integrated HIV sequences, exhibited a detectable leve
Understanding the devastation of AIDS.: Am J Nurs. 1997 Jul;97(7):26-34; quiz 35. Unique Identifier : AIDSLINE MED/97390522; Lisanti P; Zwolski K; Division of Nursing, New York University in New York, USA.; A patient admitted to your unit this morning presents a dauntingly complex clinical picture. Maria DeJesus, 34 years old, has HIV infection, which progressed to AIDS last year with an episode of Pneumocystis carinii pneumonia. She s also experienced recurrent vaginal and esophageal candidiasis and cryptococcal meningi
Reduced probability of HIV infection among crack cocaine--using injection drug users.: Am J Public Health. 1997 Jun;87(6):1008-12. Unique Identifier : AIDSLINE MED/97367482; Iguchi MY; Bux DA Jr; Department of Psychiatry, Allegheny University of the Health Sciences,; Philadelphia, Pa 19102-1192, USA.; OBJECTIVES: This study examined in greater detail the authors previously reported finding that crack use among injection drug users is associated with lower levels of infection with the human immunodeficiency virus (HIV). METHODS: Self-reported data and blood tests for HIV antibodies from 4840 out-of-treatment inject
Low prevalences of HIV infection and sexually transmitted disease among female commercial sex workers in Mexico City.: Am J Public Health. 1997 Jun;87(6):1012-5. Unique Identifier : AIDSLINE MED/97367483; Uribe-Salas F; Hernandez-Avila M; Conde-Gonzalez CJ; Juarez-Figueroa L; Allen B; Anaya-Ocampo R; Del Rio-Chiriboga C; Uribe-Zuniga P; de Zalduondo B; National Institute of Public Health, Cuernavaca, Morelos, Mexico,; Mexico City.; OBJECTIVES: This study tried to determine human immunodeficiency virus (HIV)/sexually transmitted disease (STD) prevalences among female commercial sex workers in Mexico City. METHODS: A sampling frame was constructed that included bars, massage parlors, and street corners. RESULTS: Prevalences for Treponema pallidum,
The effects of an abusive primary partner on the condom use and sexual negotiation practices of African-American women.: Am J Public Health. 1997 Jun;87(6):1016-8. Unique Identifier : AIDSLINE MED/97367484; Wingood GM; DiClemente RJ; School of Public Health, University of Alabama at Birmingham, USA.; OBJECTIVES: This study examined the consequences of having a physically abusive primary partner on the condom use and sexual negotiation practices of young African-American women. METHODS: Interviews were conducted with 165 sexually active African-American women aged 18 through 29 in San Francisco, Calif. RESULTS: Wom
AIDS--an update on the global dynamics [editorial]: Am J Public Health. 1997 Jun;87(6):901-4. Unique Identifier : AIDSLINE MED/97367460; Stein Z; Susser M
Maternal considerations in formulating HIV-related breast-feeding recommendations [editorial; comment]: Am J Public Health. 1997 Jun;87(6):904-6. Unique Identifier : AIDSLINE MED/97367461; Zimmer P; Garza C
Infant survival, HIV infection, and feeding alternatives in less-developed countries [see comments]: Am J Public Health. 1997 Jun;87(6):926-31. Unique Identifier : AIDSLINE MED/97367468; Kuhn L; Stein Z; Gertrude H. Sergievsky Center, Columbia University, New York, NY; 10032, USA.; OBJECTIVES: This study examines, in the context of the human immunodeficiency virus (HIV) epidemic, the effects of optimal breast-feeding, complete avoidance of breast-feeding, and early cessation of breast-feeding. METHODS: The three categories of breast-feeding were weighed in terms of HIV transmission and infant mo
Mortality related to sexually transmitted diseases in US women, 1973 through 1992.: Am J Public Health. 1997 Jun;87(6):938-44. Unique Identifier : AIDSLINE MED/97367470; Ebrahim SH; Peterman TA; Zaidi AA; Kamb ML; Division of Sexually Transmitted Disease/HIV Prevention, Centers for; Disease Control and Prevention, Atlanta, Ga. 30333, USA.; OBJECTIVES: This study estimated the trends in mortality related to sexually transmitted diseases (STDs) and their sequelae in US women from 1973 through 1992. METHODS: The total number of deaths was obtained from US national mortality data and from AIDS surveillance data, and current literature was reviewed to estima
Learning to recognize scarring among intravenous drug users: a tool for HIV risk reduction [letter]: Am J Public Health. 1997 Jul;87(7):1233-4. Unique Identifier : AIDSLINE MED/97384453; Horowitz HW
Short report: one case of nasal human myiasis caused by third stage instar larvae of Oestrus ovis.: Am J Trop Med Hyg. 1997 Jun;56(6):608-9. Unique Identifier : AIDSLINE MED/97374339; Lucientes J; Clavel A; Ferrer-Dufol M; Valles H; Peribanez MA; Gracia-Salinas MJ; Castillo JA; Departamento de Patologia Animal (Parasitologia), Facultad de; Veterinaria, Universidad de Zaragoza, Spain.; This is a report of a case of human nasal myiasis caused by third instar larvae of the sheep nasal bot fly, Oestrus ovis. Female flies rarely deposit first instar larvae in the eye, nostrils, and external auditory canal of humans, where they usually survive only a few days without further development. One human infest
Nitazoxanide in the treatment of cryptosporidial diarrhea and other intestinal parasitic infections associated with acquired immunodeficiency syndrome in tropical Africa.: Am J Trop Med Hyg. 1997 Jun;56(6):637-9. Unique Identifier : AIDSLINE MED/97374346; Doumbo O; Rossignol JF; Pichard E; Traore HA; Dembele TM; Diakite M; Traore F; Diallo DA; Department of Parasitology, Mali National School of Medicine and; Pharmacy, Bamako Mali.; Eighteen patients hospitalized with intestinal parasitic infections associated with diarrhea and dehydration completed a study of nitazoxanide in the treatment of Cryptosporidium parvum and other intestinal parasitic infections. Seventeen of the 18 patients were positive for human immunodeficiency virus. Twelve patien
Human T cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis in Sao Paulo, Brazil: association with blood transfusion.: Am J Trop Med Hyg. 1997 Jul;57(1):56-9. Unique Identifier : AIDSLINE MED/97384807; Domingues RB; Muniz MR; Jorge ML; Mayo MS; Saez-Alquezar A; Chamone DF; Scaff M; Marchiori PE; Department of Neurology, University of Sao Paulo, School of Medicine,; Brazil.; Human T cell lymphotropic virus type-1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) has been epidemiologically linked to prior blood transfusion. The prevalence of transfusion as a risk factor for infection varies among endemic areas. Here we report the relative frequency of reported history o
Epidemiologic surveillance of visceral leishmaniasis in Sicily, Italy.: Am J Trop Med Hyg. 1997 Jul;57(1):75-8. Unique Identifier : AIDSLINE MED/97384812; Cascio A; Gradoni L; Scarlata F; Gramiccia M; Giordano S; Russo R; Scalone A; Camma C; Titone L; Istituto di Patologia Infettiva e Virologia, Universita di Palermo,; Italy.; Visceral leishmaniasis (VL) is endemic in Sicily. Although it is a notifiable disease, there is evidence that the actual number of cases is higher than that reported. In 1987, a regional reference center for active surveillance of VL was established and it recorded a total of 284 cases through 1995, a mean of 31.5 cas
[Characteristics of rapid progressors in HIV infection]: Ann Med Interne (Paris). 1997;148(2):163-6. Unique Identifier : AIDSLINE MED/97381085; Khanlou H; Salmon-Ceron D; Sicard D; Service de Medecine Interne 2, Hopital Cochin, 27, Paris.; Approximately 10% of HIV-infected patients, the rapid progressors, progress to AIDS within the first 2 to 3 years of HIV infection. Their biological characteristics are not clearly known. They have a particular phenotype (DR) of major histocompatibility complex class-II. Anti-HIV antibodies are not neutralizing and ma
[Current status in the prevention of Mycobacterium avium complex infections in patients with HIV infection]: Ann Med Interne (Paris). 1997;148(2):167-71. Unique Identifier : AIDSLINE MED/97381086; Doco-Lecompte T; Brel F; May T; Perronne C; Service de Maladies Infectieuses et Tropicales, Hopitaux de Brabois,; Vandoeuvre.; Mycobacterium avium complex (MAC) infections in AIDS are increasingly common and contribute to the mortality in severe immunocompromised patients. In this paper, we review the published studies on the prevention of the MAC infections. Rifabutin and the new macrolides (clarithromycin, azithromycin) are shown to be effe
[Value of desensitization for reintroducing trimethoprim-sulfamethoxazole in hypersensitive patients with HIV infection]: Ann Med Interne (Paris). 1997;148(2):172-6. Unique Identifier : AIDSLINE MED/97381087; Caumes E; Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier; Pitie-Salpetriere, Paris.; The incremental administration of trimethoprim-sulfamethoxazole i.e., desensitization) in previously hypersensitive HIV-infected patients has been evaluated to date in 7 studies involving more than 10 patients. These studies differ greatly from one to another according to the inclusion criteria, exclusion criteria, an
[Extrapulmonary and disseminated pneumocystosis in AIDS. A review of the literature]: Ann Med Interne (Paris). 1997;148(2):177-83. Unique Identifier : AIDSLINE MED/97381088; Grasland A; Pouchot J; Michon C; Hertig A; Simonpoli AM; Vinceneux P; Service de Medecine Interne V, Hopital Louis-Mourier 178, Colombes.; We present a literature review about extrapulmonary and disseminated pneumocystosis in AIDS. The prevalence of such infections seems low but is probably under-estimated. Disseminated pneumocystosis occurs in patients with profound immunosuppression, who do not receive prophylaxis against Pneumocystis carinii pneumonia
[Splenic pneumocystosis disclosing extrapulmonary pneumocystosis of fatal outcome (letter)]: Ann Med Interne (Paris). 1997;148(2):184-5. Unique Identifier : AIDSLINE MED/97381089; Grasland A; Pouchot J; Michon C; Hertig A; Simonpoli A; Vinceneux P
[Hyperkalemia and acute renal insufficiency during overdose of trimethoprim-sulfamethoxazole in a patient with AIDS (letter)]: Ann Med Interne (Paris). 1997;148(2):185-6. Unique Identifier : AIDSLINE MED/97381090; Giraud O; Thomas F; Aussavy F; Jupas J; Ravaud Y
Accumulation of beta-amyloid precursor protein in HIV encephalitis: relationship with neuropsychological abnormalities.: Ann Neurol. 1997 Jul;42(1):34-40. Unique Identifier : AIDSLINE MED/97369195; Giometto B; An SF; Groves M; Scaravilli T; Geddes JF; Miller R; Tavolato B; Beckett AA; Scaravilli F; Department of Neuropathology, University of London, United Kingdom.; The pathogenesis of neuropsychological abnormalities in patients with human immunodeficiency virus type 1 (HIV-1) encephalitis is obscure because neurons are not the target of infection and severe neuronal loss occurs only late during the disease. Moreover, there is evidence indicating that HIV
Pneumocystis carinii pneumonia in Malawian children.: Ann Trop Paediatr. 1997 Jun;17(2):121-6. Unique Identifier : AIDSLINE MED/97374525; Kamiya Y; Mtitimila E; Graham SM; Broadhead RL; Brabin B; Hart CA; Tropical Child Health Group, Liverpool School of Tropical Medicine,; University of Liverpool, UK.; Sixty children aged between 1 and 23 months admitted to Queen Elizabeth Central Hospital in Blantyre, Malawi for diagnosis of acute lower respiratory tract infections (ALRI) were investigated for laboratory diagnosis of Pneumocystis carinii pneumonia (PCP) by indirect immunofluores
Cryptococcal meningitis in African children.: Ann Trop Paediatr. 1997 Jun;17(2):165-7. Unique Identifier : AIDSLINE MED/97374532; Subramanyam VR; Mtitimila E; Hart CA; Broadhead RL; Department of Microbiology, College of Medicine, Blantyre, Malawi.; Three cases of cryptococcal meningitis in Malawian children aged 6 weeks, 3 years and 9 years are described. Only 23 cases of cryptococcal meningitis in children have been described previously, but in children from Europe and the USA. These are therefore the first cases of cryptococcosis to be described in African chi
Is there a place for traditional midwives in the provision of community-health services?: Ann Trop Med Parasitol. 1997 Apr;91(3):237-45. Unique Identifier : AIDSLINE MED/97372962; Piper CJ; Traditional midwives (TM) have been involved in delivering babies, and providing a broad range of other services to women, for hundreds of years. They are usually local women with little formal education. As they are well known in their communities they are often called to assist women at the time of delivery. Two opp
[Rifabutin--a new antituberculous antibiotic]: Antibiot Khimioter. 1997;42(5):47-8. Unique Identifier : AIDSLINE MED/97353433
Bone marrow biopsy in the diagnosis of fever of unknown origin in patients with acquired immunodeficiency syndrome.: Arch Intern Med. 1997 Jul 28;157(14):1577-80. Unique Identifier : AIDSLINE MED/97379760; Benito N; Nunez A; de Gorgolas M; Esteban J; Calabuig T; Rivas MC; Fernandez Guerrero ML; Division of Infectious Diseases and Hematology (Department of; Medicine) Fundacion Jimenez Diaz, Universidad Autonoma de Madrid,; Spain.; BACKGROUND: Fever is commonly observed in patients with human immunodeficiency virus (HIV) disease and frequently eludes diagnosis. The role of bone marrow biopsy in the diagnosis of fever of unknown origin in patients infected with HIV remains controversial. PATIENTS AND METHODS: One hundred twenty-three consecutive
Prevalences of feline leukaemia virus and feline immunodeficiency virus infections in cats in Sydney.: Aust Vet J. 1997 May;75(5):323-7. Unique Identifier : AIDSLINE MED/97340316; Malik R; Kendall K; Cridland J; Coulston S; Stuart AJ; Snow D; Love DN; Department of Veterinary Clinical Sciences, University of Sydney, New; South Wales.; OBJECTIVE: To determine prevalences of feline leukaemia virus FeLV) and feline immunodeficiency virus (FIV) infections in healthy cats that, through acute misadventure or other circumstance, were presented to veterinary practitioners. Prevalences of FeLV and FIV in this population were compared to those in a populati
Systemic production of interferon-gamma inducing factor (IGIF) versus local IFN-gamma expression involved in the development of Th1 insulitis in NOD mice.: J Autoimmun. 1997 Jun;10(3):251-6. Unique Identifier : AIDSLINE MED/97361790; Rothe H; Hibino T; Itoh Y; Kolb H; Martin S; Diabetes Research Institute, Heinrich-Heine-University Dusseldorf,; Germany.; We report that the onset of Th1 insulitis is preceded by a rise of interferon-gamma inducing factor (IGIF) mRNA expression in the spleen. This systemic shift towards Th1 reactivities was underlined by a close correlation of IGIF and IL-12p40 mRNA levels in the spleen, as determined by semi-quantitative RT-PCR. Cycloph
BCG vaccination prevents insulin-dependent diabetes mellitus IDDM) in NOD mice after disease acceleration with cyclophosphamide.: J Autoimmun. 1997 Jun;10(3):271-8. Unique Identifier : AIDSLINE MED/97361793; Qin HY; Singh B; Department of Microbiology and Immunology, University of Western; Ontario and John P. Robarts Research Institute, London, Canada.; We have previously shown that immunotherapy with complete Freund s adjuvant (CFA) or BCG is highly effective in the prevention of spontaneous insulin-dependent diabetes mellitus IDDM) and in circumventing the rejection of syngeneic islet grafts in diabetic NOD mice. This protection is reversed by treatment with cyclop
Rat pancreatic islet and skin xenograft survival in CD4 and CD8 knockout mice.: J Autoimmun. 1997 Jun;10(3):309-15. Unique Identifier : AIDSLINE MED/97361798; Krieger NR; Ito H; Fathman CG; Department of Surgery, Stanford University School of Medicine, CA,; USA.; The relative contributions of the CD4+ and CD8+ T cell subpopulations in xenotransplant rejection were studied using CD4 and CD8 knockout (KO) mice. Wistar Furth (WF, RT1a) rat pancreatic islet or skin xenografts were transplanted into either CD4 or CD8 KO recipients and compared to wild-type controls. Long-term survi
Distinctions between adult and paediatric AIDS.: Immunol Today. 1997 Jul;18(7):310. Unique Identifier : AIDSLINE MED/97381551
Beta-endorphin in the immune system: a role at last?: Immunol Today. 1997 Jul;18(7):317-9. Unique Identifier : AIDSLINE MED/97381554; Panerai AE; Sacerdote P; Dept of Pharmacology, Chemotherapy and Toxicology, University of; Milano, Italy. panerai@imiucca.csi.unimi.it
Immunization with meningococcal membrane-bound lipooligosaccharide accelerates granulocyte recovery and enhances lymphocyte