HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals.

Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:41. Unique Identifier : AIDSLINE MED/97927027
Clerici M; Mazzoli S; Trabattoni D; Lo Caputo S; Meacci F; Ble C; Tofani N; Ruzzante S; Fusi ML; Semplici F; Villa ML; Mazzotta F; Centro M.S.T./U.O. Malattie Infettive, Ospedale S.M. Annunziata,; Cattedra di Immunologia, Universita' degli Studi di Milano, Milano,; Italy.

Abstract: HIV-specific mucosal and cellular immunity was analyzed in 15 heterosexual couples discordant for human immunodeficiency virus HIV) serostatus and in 50 randomly selected and presumably HIV- not exposed healthy controls. HIV-specific IgA were present in cervical swabs and/or urine of 14/15 (93%) HIV-exposed seronegative individuals; of 11/15 (73%) HIV-infected individuals; and of 4/50 (8%) controls. HIV-specific IgG were observed in cervical swabs and/or urine of 1/15 (7%) HIV-exposed seronegative individuals; of 15/15 (100%) HIV-infected patients; and of 4/50 (8%) controls. HIV env peptides-stimulated peripheral blood mononuclear cells (PBMC) of HIV-exposed seronegative individuals produced significantly more IL-2 (p.0009) and significantly less IL-10 (p .01) compared to HIV-infected individuals. Neither env peptides-stimulated IL-2 nor IL-10 production was detected in controls. These data demonstrate the concomitant presence of HIV-specific, IgA-mediated, mucosal-confined humoral immunity and HIV-specific systemic cell-mediated immunity in repeatedly-exposed HIV- individuals. These data thus confirm that a compartmentalized immune response to pathogens is possible in humans and raise the possibility of protective roles of CMI and mucosal IgA in HIV- individuals exposed to HIV. Supported by grants Istituto Superiore di Sanita' VII and VIII Progetto AIDS 1994/1995".
Keywords: *HIV Seronegativity *HIV Seropositivity/IMMUNOLOGY *Immunity, Cellular *Immunity, Mucosal *Sexual PartnersKWDhivseronegativityKWDhivseropositivity/immunologyKWDimmunity,cellularKWDimmunity,mucosalKWDsexualpartners
971130
M97B1194

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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