Identification of candidate HLA-A11 cytotoxic T lymphocyte epitopes within HIV-1 subtype E. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Identification of candidate HLA-A11 cytotoxic T lymphocyte epitopes within HIV-1 subtype E.

Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:51. Unique Identifier : AIDSLINE MED/97927035
Bond KB; Pau CP; Malegam JY; DeGroot A; Szu E; Hodge TW; Mastro TD; Limpakarnjanarat K; Stephens H; McNicholl JM; Centers for Disease Control and Prevention, Atlanta, GA. Fax: 404); 639-2108.

Abstract: In Thailand the HIV-1 epidemic is dominated by envelope subtype E. HLA-A11 is a common allele in Thailand (30-50%), but is found in increased frequency in northern Thai female sex workers highly HIV exposed but persistently seronegative (HEPS). As HIV-specific class I-restricted CTL appear to be associated with protection against HIV in other populations, we have initiated a peptide-based approach to determining if HIV-specific CTL are present in Thai HEPS. Several prediction methods were used to select 72 possible epitopes from HIV-1 subtype E sequence, including the computer based prediction program EpiMatrix. Binding was determined in a flow cytometric T2-HLA-A11 stabilization assay. Of the peptides tested 27 were identified as candidate A11 CTL epitopes in E subtype because they bind to HLA-A11. Some of these are similar to equivalent B subtype HLA-A11 CTL epitopes and overlap other HLA CTL epitopes. In env they are found in the gp120 V3 loop, a CD4 binding region and gp41. Identification of HLA-A11 CTL epitopes will facilitate the study of HIV CTL responses within this cohort (and HIV infected Thais in general) and may aid in HIV vaccine design.
Keywords: *Epitopes/IMMUNOLOGY *HIV Infections/VIROLOGY *HIV-1/IMMUNOLOGY *HLA-A Antigens/IMMUNOLOGY *T-Lymphocytes, Cytotoxic/IMMUNOLOGYKWDepitopes/immunologyKWDhivinfections/virologyKWDhiv-1/immunologyKWDhla-aantigens/immunologyKWDt-lymphocytes,cytotoxic/immunology
971130
M97B1187

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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