Mucosal and systemic immunization using DNA and protein cochleates. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Mucosal and systemic immunization using DNA and protein cochleates.

Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:64. Unique Identifier : AIDSLINE MED/97927044
Gould-Fogerite S; Zhang F; Kheiri M; Edghill-Smith Y; Wang Z; Brois D; Chen ZW; Scolpino A; Lu R; Mautone A; Feketeova E; Mannino RJ; Department of Laboratory Medicine and Pathology, UMDNJ, New Jersey; Medical School, Newark, NJ. Fax: (201) 982-7293.

Abstract: Cochleate delivery vehicles are unique, highly stable, lyophilizable, lipid-based vaccine carrier and delivery formulations. Cochleates containing proteins, peptides or DNA are highly effective vaccines when given on mucosal surfaces or parenterally. Strong, long lasting, mucosal and circulating antibody responses are generated. Cell mediated responses, including proliferative and cytolytic activities, are also induced. Oral administration, (simply by drinking), of protein cochleates leads to protection from mucosal challenge with live virus. Peroral or intramuscular delivery of encochleated DNA plasmids stimulates strong circulating antibody and splenic cytolytic responses.
Keywords: *DNA/ADMINISTRATION & DOSAGE *Immunity, Mucosal *Proteins/ADMINISTRATION & DOSAGE *Viral Vaccines/ADMINISTRATION & DOSAGEKWDdna/administration&dosageKWDimmunity,mucosalKWDproteins/administration&dosageKWDviralvaccines/administration&dosage
971130
M97B1179

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1997. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1997. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .