1997

Both ends burning : working with people with AIDS. [videorecording]: New York, NY : The Association, c1994 1 videocassette (14 min.) : sd., col. with b&w ; 1/2 in. + 1 guide (24 p.) Unique Identifier : AIDSLINE MED/9710354; Grossman J; (Producer) This new video is aimed at healthcare and social service workers, at all levels, who confront the enormously high stress levels which go with AIDS-related jobs. Through an intriguing combination of dramatization and interviews, it touches on the wide variety of personal fears and ambivalent feelings exper
AIDS, an advanced clinical update. [videorecording]: Arlington, Va. : National Hospice Organization, c1995 2 videocassettes : sd., col. ; 1/2 in. + 1 guide Unique Identifier : AIDSLINE MED/9710770; Grothe T
Pathophysiology of HIV/AIDS. [videorecording]: Philadelphia, PA : Lippincott-Raven, c1997 1 videocassette : sd., col. ; 1/2 in. + 1 guide (7 p.) (Lippincott's pathophysiology series) Unique Identifier : AIDSLINE MED/9708899
HIV chiryo manyuaru. Dai 1-han.: Kawasaki-shi : HIV Kansensha Hassho Yobo, Chiryo ni Kansuru Kenkyuhan, c1992 101 p. : ill Unique Identifier : AIDSLINE MED/9615896
AIDS : a terra sem manha e o sol sem planetas (as explosoes atomicas dos T4 por um virus radioativo).: Brasilia : Senado Federal, Centro Grafico, 1993 91 p Unique Identifier : AIDSLINE MED/9442442; Castro LP
Objetivos, estrategias e acoes.: [Brasilia?] : Ministerio da Saude, 1993 38 leaves : ill Unique Identifier : AIDSLINE MED/9442445
Eizu taisaku kankei horei tsuchishu : eizu taisaku hikkei. Heisei 5-nenban.: Tokyo : Eizu Yobo Zaidan : Hatsubaimoto Koken Shuppan Kabushiki Kaisha, Heisei 5 [1993] 233 p. : ill. ; 26 cm Unique Identifier : AIDSLINE MED/9715013
Corpo a corpa contra a AIDS.: Rio de Janeiro : Revinter, c1994 119 p. : ill Unique Identifier : AIDSLINE MED/9437069; Sa CA
Australasian Society for HIV Medicine 6th Annual Conference : together with the National Centre in HIV Virology Research and the Australian Nurses in AIDS Group : Manly Pacific Parkroyal NSW, 3-6 November 1994.: [Sydney?] : ASHM, [1994?] 306 p Unique Identifier : AIDSLINE MED/9705855
HIV-Infektionen durch Blut und Blutprodukte : Bericht des 3. Untersuchungsausschusses des 12. Deutschen Bundestages.: Bonn : Deutscher Bundestag, Referat Offentlichkeitsarbeit, 1995 671 p. : port (Zur Sache ; 1/95) Unique Identifier : AIDSLINE MED/9702614
AIDS/STD health promotion exchange. 1995, no. 1-: Amsterdam, The Netherlands : Royal Tropical Institute ; [Zimbabwe] : Southern Africa AIDS Information Dissemination Service, [1995- v. : ill Unique Identifier : AIDSLINE MED/9602418
Infection par le VIH et sida : prevention, connaissances medicales, enjeux sociaux, vie quotidienne, pratiques professionnelles. 6. ed.: Montargis : MNH, 1995 159 p. : ill Unique Identifier : AIDSLINE MED/9705707; Chambon J
Iryo jujisha no tame no eizu. Dai 1-han.: Tokyo : Nanzando, 1995 v, 183 p. : ill Unique Identifier : AIDSLINE MED/9606893; Tadano J
Harm reduction in prison : strategies against drugs, AIDS, and risk behaviour = Risikominderung im Gefangnis : Strategien gegen Drogen, AIDS, und Risikoverhalten.: Bern : Peter Lang, c1997 264 p. : ill Unique Identifier : AIDSLINE MED/9711231; Nelles J; Fuhrer A
Jenner on trial : an ethical examination of vaccine research in the age of smallpox and the age of AIDS.: Lanham, Md. : University Press of America, c1997 98 p Unique Identifier : AIDSLINE MED/9709444; Jenner E
Troubling the angels : women living with HIV/AIDS.: Boulder, Colo : Westview Press, 1997 xxix, 252 p. : ill Unique Identifier : AIDSLINE MED/9711460; Lather PA; Smithies C
AIDS in Nepal : communities confronting an emerging epidemic.: New York : AmFAR : Published in association with Seven Stories Press, c1997 208 p. : ill Unique Identifier : AIDSLINE MED/9711112; Hannum J; International AIDS Program
Human rights and public health in the AIDS pandemic.: New York : Oxford University Press, 1997 xvii, 212 p Unique Identifier : AIDSLINE MED/9710153; Gostin LO; Lazzarini Z
Manual of HIV/AIDS therapy. 1997 ed. / Douglas C. Princeton, Paul D. Chan.: Laguna Hills, Calif. : Current Clinical Strategies Pub., 1997 101 p (Current clinical strategies) Unique Identifier : AIDSLINE MED/9710260; Princeton DC; Chan PD
Cancer, AIDS, and quality of life.: New York : Plenum Press, c1997 xiii, 198 p. : ill Unique Identifier : AIDSLINE MED/9711980; Levy JA; Jasmin C; Bez G; Conference
Nutrition and HIV : a new model for treatment. Rev. and updated ed.: San Francisco : Jossey-Bass Publishers, c1998 Unique Identifier : AIDSLINE MED/9715003; Romeyn M
Das AIPP : ein AIDS-Praventionsprogramm fur Drogenabhangige : Therapiemanual. 1. Aufl.: Baltmannsweiler : Schneider Verlag Hohengehren, c1995 87 p IFT-Materialien, ISSN 0177-8870 ; 11) Unique Identifier : AIDSLINE MED/9617868; Fahrner E
Treatment of cytomegalovirus retinitis with the intraocular ganciclovir implant.: Curr Opin Ophthalmol. 1997 Jun;8(3):8-14. Unique Identifier : AIDSLINE MED/97401918; Anand R; University of Texas Southwestern Medical Center, Dallas 75231, USA.; The treatment of cytomegalovirus retinitis (CMV-R) has improved considerably in the past two years. Local ocular therapy has proved to be effective and provides significant advantages over systemic therapy with regards to better control, preventing progression, avoiding bone marrow
Modelling the cost effectiveness of lamivudine/zidovudine combination therapy in HIV infection.: Pharmacoeconomics. 1997 Jul;12(1):54-66. Unique Identifier : AIDSLINE MED/97386044; Chancellor JV; Hill AM; Sabin CA; Simpson KN; Youle M; Glaxo Wellcome UK Ltd, Uxbridge, Middlesex, England. jc16268@ggr.co.uk; The use of combination antiretroviral therapy is supported by clinical evidence for its superiority over monotherapy. Lamivudine ( 3TC ) has been studied in combination with zidovudine
Patient management and use of medication in long-term care.: Health Care Manag. 1997 Jun;3(1):77-86. Unique Identifier : AIDSLINE MED/97415197; Leibovici MM; New York University, Goldwater Memorial Hospital, Roosevelt Island,; New York 10044, USA.; The pharmacotherapeutic approach to patient management in long-term care is fraught with uncertainties and perils, including overprescription, overmedication, and adverse drug events as well as escalating costs. The author argues for alternative protocols that emphasize behavior modification, exercise, supervised hydr
Dispatch and confidentiality.: Emerg Med Serv. 1997 Aug;26(8):28-35, 44. Unique Identifier : AIDSLINE MED/97418701; Cross J; Infection Control/Emerging Concepts, Springfield, VA, USA.
The empowerment zone. Clinic helps women with HIV recover--or discover--self-esteem.: Volunt Leader. 1996 Winter;37(4):10-1. Unique Identifier : AIDSLINE MED/97415247; Larson L
AIDS morbidity and the role of the family in patient care in Uganda.: Health Transit Rev. 1997;7 Suppl:1-22. Unique Identifier : AIDSLINE MED/97421460; Ntozi JP; Department of Population Studies, Makerere University, Kampala,; Uganda.; Extended families and clans in African societies have extensive systems of treatment and patient management which can be used with AIDS sufferers. This paper used data from a baseline survey of six districts to study patient care in Uganda . The levels of AIDS illness are high, and
Screening for HIV I through the regional blood transfusion service in southwest Uganda: the Mbarara experience.: Health Transit Rev. 1997;7 Suppl:101-4. Unique Identifier : AIDSLINE MED/97421467; Rukundo H; Tumwesigye N; Wakwe VC; Department of Pathology, Mbarara University of Science and Technology,; Uganda.; Antibody screening for HIV has reduced transmission of AIDS by blood transfusion. Of the 12,768 units of blood donated to the Mbarara Regional Blood Bank between January 1992 and December 1994, 577 were found to be HIVI-positive using the ELISA technique. Percentage of positivity decreased from 5.4 in 1992 to 3.9 in 1
The psychological effect of orphanhood: a study of orphans in Rakai district.: Health Transit Rev. 1997;7 Suppl:105-24. Unique Identifier : AIDSLINE MED/97421468; Sengendo J; Nambi J; Faculty of Social Sciences, Makerere University, Kampala.; This paper examines the psychological effect of orphanhood in a case study of 193 children in Rakai district of Uganda . Studies on orphaned children have not examined the psychological impact. Adopting parents and schools have not provided the emotional support these children often
Widowhood, remarriage and migration during the HIV/AIDS epidemic in Uganda.: Health Transit Rev. 1997;7 Suppl:125-44. Unique Identifier : AIDSLINE MED/97421469; Ntozi JP; Department of Population Studies, Makerere University, Kampala,; Uganda.; Recently the levels of widowhood have increased in countries of sub-Saharan Africa that are afflicted by the HIV/AIDS epidemic. This paper reviews the cultures of several societies in Uganda in relation to the treatment of widows. Using a data set based on a sample of 1797 househol
Fertility levels and trends in the face of the AIDS epidemic in Uganda.: Health Transit Rev. 1997;7 Suppl:145-55. Unique Identifier : AIDSLINE MED/97421470; Ntozi JP; Nakanaabi IM; Lubaale YA; Department of Population Studies, Makerere University, Kampala,; Uganda.; The paper uses data on ever-married women interviewed in 1992 and 1995 surveys in six districts of Uganda . Total fertility rates declined during the inter-survey period from 7.3 to 6.0. Women in households that experienced AIDS-related deaths had lower fertility levels than women i
HIV/AIDS, change in sexual behaviour and community attitudes in Uganda.: Health Transit Rev. 1997;7 Suppl:157-74. Unique Identifier : AIDSLINE MED/97421471; Ntozi JP; Kirunga CT; Department of Population Studies, Makerere University, Kampala,; Uganda.; The spread of HIV/AIDS is mostly through sexual intercourse and is largely influenced by behaviour and attitude. Data based on a sample of 1797 households are used to study changes in sexual behaviour and attitudes sickness and death in Ugandan communities, which were due to the realization that too many deaths were o
Socio-economic determinants of HIV serostatus: a study of Rakai District, Uganda.: Health Transit Rev. 1997;7 Suppl:175-88. Unique Identifier : AIDSLINE MED/97421472; Kirunga CT; Ntozi JP; Department of Population Studies, Makerere University, Kampala,; Uganda.; The objective of the study was to establish the extent to which socio-economic status affects the acquisition of HIV. Data were collected in 1992 from 1784 respondents in Rakai district by the Rakai Project, with results for HIV serology and information on demographic, socio-economic and some behavioural variables. Le
The AIDS epidemic and infant and child mortality in six districts of Uganda.: Health Transit Rev. 1997;7 Suppl:189-205. Unique Identifier : AIDSLINE MED/97421473; Ntozi JP; Nakanaabi IM; Department of Population Studies, Makerere University, Kampala,; Uganda.; Several studies in sub-Saharan Africa have associated infant and child mortality with the AIDS epidemic in the region. The paper uses retrospective survey data of six districts in the east, south and west of Uganda to study infant and child mortality, which increased in the 1980s p
AIDS mortality in Uganda: circumstances, factors and impact of death.: Health Transit Rev. 1997;7 Suppl:207-24. Unique Identifier : AIDSLINE MED/97421474; Ntozi JP; Lubaale YM; Nakanaabi IM; Department of Population Studies, Makerere University, Kampala,; Uganda.; HIV/AIDS is a serious problem in sub-Saharan Africa. The disease affects the most sexually active adults of the population, who belong to the most productive age groups, and some of whom are breadwinners. The paper uses data from a baseline survey of six districts of Uganda to stud
Livelihood and the risk of HIV/AIDS infection in Ghana: the case of female itinerant traders.: Health Transit Rev. 1997;7 Suppl:225-42. Unique Identifier : AIDSLINE MED/97421475; Anarfi JK; Appiah EN; Awusabo-Asare K; Institute of Statistical, Social and Economic Research, University of; Ghana, Legon.; Itinerant trading is the second major economic activity for women who constitute an important chain in the distribution of goods in West Africa. Historically they have played important roles in the political economy of Ghana . With the outbreak of AIDS these women, some of whom move
Effect of AIDS on children: the problem of orphans in Uganda.: Health Transit Rev. 1997;7 Suppl:23-40. Unique Identifier : AIDSLINE MED/97421461; Ntozi JP; Department of Population Studies, Makerere University, Kampala,; Uganda.; The problem of orphans is serious in sub-Saharan Africa and has been increasing with the deaths of both parents from AIDS. A study of six districts of Uganda conducted in 1992 investigated the problem. Almost all the orphans are cared for by their extended family members who made t
Health-seeking behaviour of persons with HIV/AIDS in Ghana.: Health Transit Rev. 1997;7 Suppl:243-56. Unique Identifier : AIDSLINE MED/97421476; Awusabo-Asare K; Anarfi JK; Department of Geography, University of Cape Coast, Ghana.; Historically, diseases whose aetiology could not be readily explained have been given supernatural explanations among the various ethnic groups in Ghana . Now HIV infection, with no known cure and origin, has been given a supernatural explanation. Such an explanation of disease causa
Postpartum sexual abstinence in the era of AIDS in Ghana: prospects for change.: Health Transit Rev. 1997;7 Suppl:257-70. Unique Identifier : AIDSLINE MED/97421477; Awusabo-Asare K; Anarfi JK; Department of Geography, University of Cape Coast.; Postpartum sexual abstinence for females has been identified as one of the socio-cultural factors with the potential for creating conditions for the sexual spread of HIV in areas where it is practised. In general, women are expected to abstain from sex after childbirth in order to ensure the survival of the mother and
Attitudes to and management of HIV/AIDS among health workers in Ghana: the case of Cape Coast municipality.: Health Transit Rev. 1997;7 Suppl:271-80. Unique Identifier : AIDSLINE MED/97421478; Awusabo-Asare K; Marfo C; Department of Geography and Tourism, University of Cape Coast, Ghana.; Health Care Workers as key players in the prevention and management of diseases and important opinion and community leaders have become targets for studies, more so with the outbreak of HIV. Their perceptions, attitudes and practices have implications for the management of diseases in both health centres and communiti
Vulnerability to sexually transmitted disease: street children in Accra.: Health Transit Rev. 1997;7 Suppl:281-306. Unique Identifier : AIDSLINE MED/97421479; Anarfi JK; Institute of Statistical, Social and Economic Research, University of; Ghana, Legon.
Women's role in reproductive health decision making and vulnerability to STD and HIV/AIDS in Ekiti, Nigeria.: Health Transit Rev. 1997;7 Suppl:329-36. Unique Identifier : AIDSLINE MED/97421482; Orubuloye IO; Oguntimehin F; Sadiq T; Department of Sociology, Ondo State University, Ado-Ekiti, Nigeria.; An exploratory study of women s role in reproductive decision making in Ekiti shows that women in the state are increasingly taking active decisions on matters affecting their daily lives. More women than ever before believed that they could take decisions on family size, when to have a baby and choice of spacing peri
'Main' girlfriends, girlfriends, marriage, and money: the social context of HIV risk behaviour in sub-Saharan Africa.: Health Transit Rev. 1997;7 Suppl:361-75. Unique Identifier : AIDSLINE MED/97421484; Meekers D; Calves AE; Department of Population Dynamics, School of Hygiene and Public; Health, Johns Hopkins University, USA.; Research on African societies documents the magnitude of the AIDS epidemic, and shows that at younger ages women are more likely to be affected than men. Young African women are particularly vulnerable to HIV infection because sexual relations with men are an important means to achieve social and economic status, and
Men, women and the trouble with condoms: problems associated with condom use by migrant workers in rural Zambia.: Health Transit Rev. 1997;7 Suppl:377-91. Unique Identifier : AIDSLINE MED/97421485; Bond V; Dover P; Department of Sociology and Social Anthropology, Hull University, UK.; Understanding cultural attitudes to condoms is of the utmost importance in promoting their use as a means of protection against HIV transmission. This article examines condom use in relation to what people see as the purpose of sex, what good sex entails and how this relates to ideas of being a proper woman or man. It
Using rapid research to develop a national strategy to assist families affected by AIDS in Tanzania.: Health Transit Rev. 1997;7 Suppl:393-420. Unique Identifier : AIDSLINE MED/97421486; Hunter S; Kaijage F; Maack P; Kiondo A; Masanja P; USAID, Dar es Salaam, Department of History, University of Dar es; Salaam.; Although information on African family adaptation to the AIDS epidemic is critical to planning and managing government, donor and NGO programs of assistance, current knowledge is limited to a small number of research studies. An AIDS prevention project in Tanzania undertook a rap
A three-year follow-up survey of demographic changes in a Ugandan town on the trans-African highway with high HIV-1 seroprevalence.: Health Transit Rev. 1997;7 Suppl:41-7. Unique Identifier : AIDSLINE MED/97421462; Pickering H; Nunn AJ; Medical Research Council/Uganda Virus Research Institute, Entebbe.; A 1991 serosurvey in a Ugandan trading town on the trans-African highway reported a 40 per cent HIV-1 prevalence in adults. Three years later in a repeat survey of the 531 adults resident in 1991, 279 (53%) were still present, 196 (37%) had left and 56 11%) had died. There were 138 new residents and 46 children had be
Awareness and knowledge of AIDS among Indian women: evidence from 13 states.: Health Transit Rev. 1997;7 Suppl:421-65. Unique Identifier : AIDSLINE MED/97421487; Balk D; Lahiri S; Program on Population, East-West Center, Honolulu.; Over 30,000 ever-married women in 13 (out of 25) Indian states where HIV is thought to be highly prevalent-Maharashtra, West Bengal, Tamil Nadu, and ten other less populous states-were surveyed about their awareness and knowledge of AIDS. Only one in six women had heard of AIDS. Among those, knowledge about transmissi
Determinants of extramarital sex in the Philippines.: Health Transit Rev. 1997;7 Suppl:467-79. Unique Identifier : AIDSLINE MED/97421488; Ahlburg DA; Jensen ER; Perez AE; Industrial Relations Center, University of Minnesota, USA.; Understanding the factors associated with sexual behaviour is critical in slowing the spread of HIV in the Philippines , where sexual transmission accounts for most HIV infections, with the majority from heterosexual activity. Further, unprotected sex is common, as is sex with
What do school children and teachers in rural Maharashtra think of AIDS and sex?: Health Transit Rev. 1997;7 Suppl:481-6. Unique Identifier : AIDSLINE MED/97421489; Verma RK; Sureender S; Guruswamy M; International Institute for Population Sciences, Deonar, Mumbai,; India.; This paper discusses findings on issues related to sex and AIDS based on focus-group discussions conducted among students and teachers in the rural areas of Maharashtra. Most students were not sure whether AIDS could affect them, or how it could be contracted; some standard IX girl students stated the need for sex edu
Serial marriages and AIDS in Masaka District.: Health Transit Rev. 1997;7 Suppl:49-66. Unique Identifier : AIDSLINE MED/97421463; Adeokun LA; Nalwadda RM; Institute of Statistics and Applied Economics, Makerere University,; Kampala, Uganda.; In the process of studying the functioning of households under the conditions of the AIDS epidemic in the districts of Masaka, Kabarole and Rukungiri, information was collected on the marital history of persons aged 12 years and above who had ever been involved in a regular union or marriage. That information allows t
The role of the environment in the sexual activity of school students in Tororo and Pallisa Districts of Uganda.: Health Transit Rev. 1997;7 Suppl:67-81. Unique Identifier : AIDSLINE MED/97421464; Twa-Twa JM; Uganda Medical and Dental Practitioners Council, Wandegeya, Uganda.; Several models of adolescent sexual activity have previously been published and most of them suggest two basic components, biological and sociological. This article highlights important environmental factors in shaping the sexual behaviour of the school-going youth in Uganda . Stude
Underlying factors in female sexual partner instability in Kampala.: Health Transit Rev. 1997;7 Suppl:83-8. Unique Identifier : AIDSLINE MED/97421465; Twa-Twa J; Nakanaabi I; Sekimpi D; Uganda Medical and Dental Practitioners Council, Wandegeya, Uganda.; Divorced or separated persons are more likely to be infected with HIV than those in marital unions: sexual partner instability appears to have significant implications in STD/HIV transmission. While this appears empirically true, most current STD/HIV preventive strategies do not seem to address partner instability as
Adolescent sexual networking and HIV transmission in rural Uganda.: Health Transit Rev. 1997;7 Suppl:89-100. Unique Identifier : AIDSLINE MED/97421466; Konde-Lule JK; Sewankambo N; Morris M; Institute of Public Health, Makerere University, Kampala, Uganda.; Information on 861 adolescents shows that in 1991 36 per cent reported having been sexually active in the previous 12 months, but only 6.2 per cent had ever used a condom (11% males, 2.4% females). The HIV infection rate was 5.9 per cent overall, 0.8 per cent in males and 9.9 per cent in females. The proportion sexual
Ganciclovir. A pharmacoeconomic review of its use as intravenous or oral maintenance therapy in the management of cytomegalovirus retinitis in patients with AIDS.: Pharmacoeconomics. 1997 Aug;12(2):209-28. Unique Identifier : AIDSLINE MED/97401945; Perry CM; Davis R; Adis International Limited, Auckland, New Zealand. demail@adis.co.nz; Cytomegalovirus retinitis, an opportunistic infection caused by the herpesvirus cytomegalovirus , is a major cause of illness in patients with advanced AIDS. As infected patients require long term drug treatment to delay disease progression and minimise loss of vision, the disease i
Ganciclovir. A pharmacoeconomic review of its use as intravenous or oral maintenance therapy in the management of cytomegalovirus retinitis in patients with AIDS.: Pharmacoeconomics. 1997 Aug;12(2 Pt 1):209-28. Unique Identifier : AIDSLINE MED/97421514; Perry CM; Davis R; Adis International Limited, Auckland, New Zealand. demail@adis.co.nz; Cytomegalovirus retinitis, an opportunistic infection caused by the herpesvirus cytomegalovirus , is a major cause of illness in patients with advanced AIDS. As infected patients require long term drug treatment to delay disease progression and minimise loss of vision, the disease i
Management of HIV-/HBV-exposed healthcare workers. Pike, Plymouth Meeting, PA 19462, USA.: In: Healthcare Risk Control. Volume 4. Plymouth Meeting, PA : ECRI, 1996. 19 p. (Infection control ; no. 6.2) Unique Identifier : AIDSLINE MED/97620663
Liposomal amphotericin B in the treatment of invasive fungal infections.: Bristol, England : U.K. National Health Service, South and West Regional Health Authority, 1995. 12 p. (Development and evaluation committee report ; no. 37) Unique Identifier : AIDSLINE MED/97620731; Bliss E; Directorate (U.K.); Canynge Hall, Whiteladies Road, Bristol BS8 2PR, England.; http://www.epi.bris.ac.uk/rd/publicat/dec/dec37.htm).; (1) Invasive fungal infection arises from immunocompromisation associated usually with cancer or leukaemia or immuno-suppressive therapy perhaps in the context of transplantation, or AIDS. (2) Sufficiently high doses of conventional amphotericin B are often not possible for reasons of toxicity and renal impairment.
Protecting the physician in HIV misdiagnosis cases.: Duke Law J. 1996 Nov;46(2):431-59. Unique Identifier : AIDSLINE MED/97620803; Schmid CA
Hospital care for persons with AIDS in the European Union.: Health Policy. 1997 Aug;41(2):157-76. Unique Identifier : AIDSLINE MED/97417143; Postma MJ; Tolley K; Leidl RM; Downs AM; Beck EJ; Tramarin AM; Flori YA; Santin M; Antonanzas F; Kornarou H; Paparizos VC; Dijkgraaf MG; Borleffs J; Luijben AJ; Jager JC; Department of Public Health Forecasting, Bilthoven, The Netherlands.; This study estimates the current and future hospital resources for AIDS patients in the European Union (EU), using multinational scenario analysis (EU Concerted Action BMH1-CT-941723). In collaboration with another EU-project ( Managing the Costs of HIV Infection ), six national European studies on the utilization of
Aspects of male circumcision in sub-equatorial African culture history.: Health Transit Rev. 1997;7 Suppl:337-60. Unique Identifier : AIDSLINE MED/97421483; Marck J; Health Transition Centre, National Centre for Epidemiology and; Population Health, Australian National University.; This paper describes the general cultural background of male circumcision for the Bantu speaking peoples of sub-equatorial Africa. Where the contemporary cultural context of male circumcision is now variable and often transformed amongst groups who continue the practice, traditional practices were commonly of a partic
Identification of a novel mitochondrial dNTP carrier and its interaction with anti-HIV nucleoside analogs (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A414 1997. Unique Identifier : AIDSLINE MED/97620923; Bridges EG; Jiang ZL; Cheng YC; Yale University School of Medicine, New Haven, CT 06410; Recent clinical and laboratory findings suggest damage to mitochondrial function as a mechanism of toxicity of antiviral nucleoside analog (nsa s). Though mitochondria contain kinases that can phosphorylate nucleosides, our previous studies suggest the nsa-triphosphates (nsa-TPs) that inhibit mitochondrial DNA replica
Effects of standard chemotherapy regimens on HIV plasma RNA levels in patients with HIV-associated malignancies (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A193 1997. Unique Identifier : AIDSLINE MED/97621065; Lyter DW; Beckman EJ; AIDS Malignancy Program, Illinois Masonic Cancer Center, Chicago, IL; Numerous studies have suggested that plasma levels of human immunodeficiency virus (HIV) RNA are strongly associated with HIV disease progression. Currently, the impact of new anti-retroviral regimens on HIV RNA levels and HIV prognosis are being studied intensively. However, very little is known about the effects of
Pilot trial of cyclophosphamide, doxorubicin, vincristine, prednisone, etoposide + antiretrovirals + G-CSF + erythropoietin in AIDS-associated non-Hodgkin's lymphoma: CALGB 9155 (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A195 1997. Unique Identifier : AIDSLINE MED/97621067; Feigal EG; Petroni GR; Freter C; Johnson JL; Barcos M; Peterson BA; CALGB, Chicago, IL; Forty-six patients with previously untreated histologically confirmed intermediate and high-grade AIDS-associated non-Hodgkin s lymphoma (NHL) entered CALGB s first trial in AIDS-malignancies evaluating escalating doses of cyclophosphamide(C), doxorubicin(H), vincristine(O), predni
Complete response to fludarabine in a patient with multifocal gastrointestinal MALT lymphoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A1066 1997. Unique Identifier : AIDSLINE MED/97621091; Neuman J; Ray D; Mehta K; Gruber T; Aquino M; Monmouth Medical Center, Long Branch, NJ; Mucosa associated lymphoid tissue (MALT) lymphoma is an extranodal non-Hodgkin s B-Cell lymphoma usually localized to a specific tissue in a given patient. Sites of tissue involvement may include the gastrointestinal tract (usually the stomach), salivary glands, thyroid, thymus, lung, liver, orbital tissue, conjunctiv
Patients with advanced AIDS-related Kaposi's sarcoma (EKS) no longer require systemic therapy after introduction of effective antiretroviral therapy (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A162 1997. Unique Identifier : AIDSLINE MED/97621035; Volm MD; Wernz J; Kaplan Cancer Center, New York University Medical Center, New York, NY; Although patients with early EKS are managed with local therapy, those with advanced disease require systemic treatment with interferon or cytotoxic chemotherapy. Most patients respond to systemic therapy, however, in the past nearly all have required chronic long term therapy to control their disease. With the advent
Liposomal encapsulated daunorubicin (DaunoXome) in AIDS-related pulmonary Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A189 1997. Unique Identifier : AIDSLINE MED/97621061; Gill PS; Wernz J; Myers A; Scadden D; Espina B; Mukwaya G; Sandhaus R; University of Southern California, Los Angeles, CA; An open-label Phase II clinical trial was conducted to evaluate the safety and efficacy of liposomal daunorubicin (DaunoXome) in 53 patients with AIDS-related pulmonary Kaposi s sarcoma (KS). Forty-eight patients (91%) had pulmonary KS diagnosed by bronchoscopy and/or l
A randomized comparative trial of Doxil versus bleomycin and vincristine (BV) in the treatment of AIDS-related Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A190 1997. Unique Identifier : AIDSLINE MED/97621062; Stewart JS; Jablonowsky H; Goebel FD; L'age M; Spittle M; Opravi M; Doxil Trial Group; St. Mary's Hospital, London, UK; Introduction: Kaposi s Sarcoma remains prevalent in patients with AIDS and systemic cytotoxic chemotherapy is frequently necessary for those patients with the more severe manifestations of this disease. Combinations of bleomycin and vincristine (BV), with or without addition of doxorubicin, (ABV) remain the most commo
Comparison study of liposomal doxorubicin (DOX) alone or with bleomycin and vincristine (DBV) for treatment of advanced AIDS-associated Kaposi's sarcoma (AIDS-KS): AIDS Clinical Trial Group (ACTG) protocol 286 (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A191 1997. Unique Identifier : AIDSLINE MED/97621063; Mitsuyasu R; yon Roenn J; Krown S; Kaplan L; Testa M et al; UCLA, Los Angeles, CA; Pegylated liposomal doxorubicin (DOX) is a safe and effective treatment for pts with advanced AIDS-KS. The addition of other chemotherapy drugs to DOX might increase KS tumor response, but might also lower tolerance of therapy. To test this, the ACTG performed a phase III study comparing DOX to DBV in advanced-stage A
Cultured endothelial cells (ECs) can be infected by human herpes virus-8 (HHV-8), the possible etiologic agent for Kaposi's sarcoma (KS) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A192 1997. Unique Identifier : AIDSLINE MED/97621064; Arlen PM; Offermann MK; Emory University, Department of Medicine and Winship Cancer Center,; Atlanta, GA; KS is a multifocal vascular lesion characterized by abnormal proliferation of endothelial-like KS cells. As the most common neoplasm affecting AIDS patients, a much higher rate is observed in homosexual men than other risk groups, suggesting a sexually transmitted cofactor. Recently genomic sequences of a novel herpes
Prospective, multicenter phase II trial of ABVD chemotherapy with G-CSF in HIV-infected patients with Hodgkin's disease (HD): AIDS Clinical Trials Group (ACTG) study 149 (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A194 1997. Unique Identifier : AIDSLINE MED/97621066; Levine AM; Cheung T; Huang J; Testa M; USC School of Medicine, Los Angeles, CA; Although HD is not considered an AIDS-defining diagnosis, recent studies suggest a statistically increased incidence of HD in HIV infected persons (Lyter, JCO; 13:2540 1995). No large prospective trials are yet published regarding the results of standard ABVD chemotherapy (Bonadonna, Cancer; 36:252 1975) in HIV infect
A subpopulation of immature blood dendritic cells is highly susceptible to infection by macrophage-tropic HIV-1.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:18. Unique Identifier : AIDSLINE MED/97927010; Crawford K; Alper C; Shi B; Vasir D; Gabuzda D; Dana Farber Cancer Institute, Boston, MA. Fax: (617) 632-3113.; Dendritic cells (DC) are unique antigen-presenting cells that are widely distributed in lymphoid and non-lymphoid tissues. Previous studies have suggested that DC play an important role in the transmission of HIV-1 to T cells. However, controversy exists regarding whether DC are directly susceptible to HIV-1 infection
A sensitive microtiter infectivity assay for macrophage-tropic and primary isolates of HIV-1 based on the transactivation of a stably integrated gene for the green fluorescent protein.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:19. Unique Identifier : AIDSLINE MED/97927011; Tan GT; Honnen WJ; Kayman SC; Pinter A; Laboratory of Retroviral Biology, Public Health Research Institute,; New York, NY. Fax: (212) 578-0804.; Reporter cell lines for the quantitative assay of HIV infectivity were developed using HOS cells rendered susceptible to HIV infection by transfection of genes for CD4, and either CCR5 or CXCR4 as the respective coreceptor for macrophage-tropic and T cell tropic HIV isolates. This 96-well microtiter assay is based on
Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:20. Unique Identifier : AIDSLINE MED/97927012; June CH; Riley JL; Levine BL; Feng Y; Kaushal S; Ritchey DW; Bernstein W; Weislow OS; Berger EA; St. Louis DC; Carroll RG; Division of Retrovirology, Walter Reed Army Institute for Research,; Bethesda, MD. Fax: (301) 295-6484.; A potent anti-viral effect was found to be mediated by certain forms of CD28 signal transduction. CD28 receptor costimulation can lead to polyclonal expansion of CD4+ cells from HIV-infected donors during cell culture. Moreover, CD28 stimulation rendered CD4+ cells from uninfected donors highly resistant to HIV-1 infe
Infection of cats with FIV by injection with cloned proviral DNA.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:23. Unique Identifier : AIDSLINE MED/97927015; Sparger EE; Louie H; Ziomeck AM; Luciw PA; Department of Veterinary Medicine and Epidemiology, University of; California, Davis, CA. Fax: (916) 752-0414.; Establishment of infection of animals with a viral clone is important for investigating viral determinants of pathogenesis and monitoring sequence changes in the viral genome in vivo, and may find utility as a means of immunization with live-attenuated virus. To test the efficiency of intramuscular (IM) injection of c
HIV-1 subtypes differ in disease progression.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:24. Unique Identifier : AIDSLINE MED/97927016; Kanki P; Hamel D; Sankale JL; Hsieh CC; Thior I; Essex M; Mboup S; Harvard AIDS Institute, Boston, MA. Fax: (617) 432-3575.; Much of our knowledge of HIV-1 pathogenesis comes from the developed world, where HIV infection is almost exclusively due to subtype B. The recognition of the different HIV-1 subtypes, have led many to question whether properties of HIV-1 infection and its consequences as a whole can be generalized among different sub
HIV seroconverters in domestic HIVNET studies: clinical, epidemiologic, virologic and immunologic findings in primary HIV infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:27. Unique Identifier : AIDSLINE MED/97927017; Celum CL; Sheppard HW; Donnell D; Wilson SE; Douglas J; Mayer K; Flores J; Marmor M; Buchbinder SP; Seattle HIVNET, Seattle, WA. Fax: (206) 521-5828.; HIVNET is an NIH-funded multi-site HIV prevention trials network. HIVNET studies include a phase II vaccine trial in conjunction with AVEG, microbicide, perinatal and behavioral intervention trials with biologic outcomes. In the HIVNET Vaccine Preparedness Study, 8 domestic sites enrolled 4892 high-risk HIV-negative g
Tracking the replication of lentiviral quasi-species in vivo at single-cell resolution.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:30. Unique Identifier : AIDSLINE MED/97927018; Haase A; Reinhart T; Rogan M; Amedee AM; Murphey-Corb M; Rausch D; Eiden L; Department of Microbiology, University of Minnesota, Minneapolis, MN.; Fax: (612) 626-0623.; Transmission of HIV and SIV is accompanied by striking reductions in the genetic diversity of viruses that comprise the donor quasi-species. To understand how replication of individual viral genotypes in particular types of cells or anatomic sites might reshape the population we have devised an experimental approach t
Early pathogenesis of SIV genital transmission.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:31. Unique Identifier : AIDSLINE MED/97927019; Preston A; Aaron Diamond AIDS Research Center, Tuxedo, NY. Fax: (914) 351-2015.; The rhesus (Rh) macaque genital transmission model uses simian immunodeficiency virus (SIV) to address early steps of pathogenesis, vaccine protection and co-factors of transmission. Dual tropic SIVmac, readily crosses the intact epithelium of the penile urethra, vagina or rectum. Dual tropic simian-human immunodefici
Positron emission tomography images of AIDS pathogenesis.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:32. Unique Identifier : AIDSLINE MED/97927020; Pauza CD; Pyzalski R; Perlman SB; Hanson J; Sossmann J; Scharko AM; Graziano FM; University of Wisconsin-Madison, Madison, WI. Fax: (608) 262-9148.; Positron emission tomography (PET) with radiolabelled-fluorodeoxyglucose (FDG) radiographic imaging technique that identifies issues with highest metabolic activation. During HIV or SIV infection, very high rates of glucose uptake in virus infected lymphoid tissues distinguished these sites from unaffected tissues and
Phenotypic and immunologic changes in SIVMne variants that emerge in association with progression to AIDS are determined by multiple changes in gag and env.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:33. Unique Identifier : AIDSLINE MED/97927021; Kimata JT; Chackerian B; Rudensey L; Overbaugh J; Department of Microbiology, University of Washington, Seattle, WA.; Fax: (206) 543-8297.; In infected macaques, SIVMne evolves from a M-tropic, slowly replicating, minimally cytopathic, nonsyncytium-inducing virus slow-low/NSI) to a T-tropic, rapidly replicating, highly cytopathic, syncytium-inducing virus population (rapid-high/SI) in association with the progression to AIDS. During the course of infectio
Post entry determinants of primate lentivirus infectivity.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:34. Unique Identifier : AIDSLINE MED/97927022; Stevenson M; Brichacek B; Jacque JM; Mann A; Sleigh R; Sharkey M; Sharova N; Lifson J; Hahn B; Hirsch V; University of Massachusetts Medical Center, Molecular Genetics and; Microbiology, Worcester, MA.; Following fusion of viral with host cell membranes, viral nucleic acids are transported to the host cell nucleus where integration of viral with host cell DNA occurs. We have previously demonstrated that the structural gagMA protein and the Vpr/Vpx proteins are important in allowing viral nucleic acids to access the h
HIV-1 inhibitory activity of CD8+ cell supernatants is distinct from that of RANTES, MIP-1alpha and MIP-1beta.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:40. Unique Identifier : AIDSLINE MED/97927026; Klotman ME; Mosoian A; Teixeira A; Sperber K; Piwoz J; Caron E; Mt. Sinai School of Medicine, New York, NY. Fax: (212) 534-3240.; CD8+ supernatant (sups)inhibition of HIV-1 replication in lymphocytes is at least partially due to the chemokines (ccs) RANTES, MIP-1alpha and MIP-1beta. To further define the inhibitory activity of CD8+ sups we compared the inhibitory activity of transformed CD8+ cells with that of recombinant chemokines. Sups from H
HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:41. Unique Identifier : AIDSLINE MED/97927027; Clerici M; Mazzoli S; Trabattoni D; Lo Caputo S; Meacci F; Ble C; Tofani N; Ruzzante S; Fusi ML; Semplici F; Villa ML; Mazzotta F; Centro M.S.T./U.O. Malattie Infettive, Ospedale S.M. Annunziata,; Cattedra di Immunologia, Universita' degli Studi di Milano, Milano,; Italy.; HIV-specific mucosal and cellular immunity was analyzed in 15 heterosexual couples discordant for human immunodeficiency virus HIV) serostatus and in 50 randomly selected and presumably HIV- not exposed healthy controls. HIV-specific IgA were present in cervical swabs and/or urine of 14/15 (93%) HIV-exposed seronegati
HIV-1 specific mucosal immunity in semen and cervix of infected individuals.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:42. Unique Identifier : AIDSLINE MED/97927028; Musey L; McElrath MJ; University of Washington/Fred Hutchinson Cancer Research Center,; Seattle, WA. Fax: (206) 667-4411.; HIV-1 is predominantly transmitted through the mucosal route. The presence of HIV-specific mucosal T cells may contribute to the selection and the level of transmitted viruses. We evaluated the presence and the function of HIV-1 specific CTL in the semen of 19 HIV+ men and in the cervix of 19 HIV+ women. Mucosal T cel
Cross reactive CTL responses in persons infected with different HIV viral clades.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:43. Unique Identifier : AIDSLINE MED/97927029; Gotch F; McAdam S; Whitworth J; Charing Cross & Westminster Medical School, Dept. Immunology, Chelsea; & Westminster Hospital, London, United Kingdom. Fax: 181-746-5997.; 8,500 persons/day are infected with HIV, 90% of whom live in developing countries. It would cost 300 billion dollars to treat all HIV infected individuals in the world with modern, potent, antiretroviral drugs. This is clearly not feasible and there is an urgent need to develop a vaccine for HIV. Such a prophylactic v
CTL cross-reactivity among different HIV-1 clades.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:44. Unique Identifier : AIDSLINE MED/97927030; Cao H; Kanki P; Sankale JL; Kalams S; MBoup S; Walker B; Massachusetts General Hospital, Infectious Disease Unit, Boston, MA.; Fax: (617) 726-5411.; Despite recent advances in antiviral therapy for HIV infection, successful global intervention will require an effective vaccine. Expanding evidence suggests that cytotoxic T lymphocyte (CTL) responses will be an important component of such a vaccine. The varying geographic distribution of HIV-1 clades, with the relat
Dendritic cell vaccine models allow for identification of novel T cell epitopes in HIV-1 nef.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:47. Unique Identifier : AIDSLINE MED/97927031; Wilson CC; Rinaldo CR; Tueting T; Martin D; Farhood H; Lotze MT; Storkus WJ; University of Pittsburgh Medical Center, Pittsburgh, PA. Fax: 412); 624-1172.; An in vitro vaccine model for HIV-1 was developed using cultured DC as stimulators and naive T cells from HIV-1 seronegative donors as responders. DC cultured from nonadherent PBMC in GM-CSF and IL-4 for 5-10 days were pulsed with recombinant Nef antigen or were transfected with the HIV-1 nef gene. Human IL-12 and IFN
Engineering of immune responses to DNA immunization via co-delivery of costimulatory molecule genes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:49. Unique Identifier : AIDSLINE MED/97927033; Kim JJ; Bagarazzi ML; Hu YD; Trivedi N; Chattergoon MA; Dang K; Agadjanyan MA; Mahalingam S; Boyer JD; Wang B; Weiner DB; University of Pennsylvania, Philadelphia, PA. Fax: (215) 573-9436.; Costimulatory molecules play an important role in the induction of T cell-mediated immune responses. Effective T cell activation by APC requires two stimuli: the first signal originates from the binding of antigen-MHC and T cell receptor molecules which confers specificity. The second signal comes from the costimulato
Protection of rhesus macaques from homologous and heterologous SHIV challenge using oligomeric gp160.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:50. Unique Identifier : AIDSLINE MED/97927034; VanCott TC; Lewis M; Kaminski R; Mascola J; Kalyanaraman V; Pragman S; Frampton L; Yalley-Ogunro J; Greenhouse J; Lu Y; Jenkins S; Richardson C; Ulrich T; Wassef N; Alving C; Lowell G; Birx D; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-4177.; Protection of rhesus macaques from i.v. challenge with SHIV(HXBc2) was evaluated using affinity purified, oligomeric gp160 (ogp160-IIIB) or monomeric gp120-IIIB formulated with alhydrogel, monophosphoryl lipid A (MPL) or polyphosphazene. Previous studies in rabbits demonstrated the ability of ogp160 formulated in MPL
Identification of candidate HLA-A11 cytotoxic T lymphocyte epitopes within HIV-1 subtype E.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:51. Unique Identifier : AIDSLINE MED/97927035; Bond KB; Pau CP; Malegam JY; DeGroot A; Szu E; Hodge TW; Mastro TD; Limpakarnjanarat K; Stephens H; McNicholl JM; Centers for Disease Control and Prevention, Atlanta, GA. Fax: 404); 639-2108.; In Thailand the HIV-1 epidemic is dominated by envelope subtype E. HLA-A11 is a common allele in Thailand (30-50%), but is found in increased frequency in northern Thai female sex workers highly HIV exposed but persistently seronegative (HEPS). As HIV-specific class I-restricted
Non-recombinant, near-full length reference clones for HIV-1 subtypes A through H.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:53. Unique Identifier : AIDSLINE MED/97927037; Gao F; Robertson DL; Morrison SG; Carruthers C; Jian B; Chen Y; Srinivasan A; Girard M; Barre-Sinoussi F; Hahn BH; University of Alabama at Birmingham, Birmingham, AL. Fax: (205); 934-1580.; The classification of HIV-1 into distinct lineages, known as sequence subtypes, within the HIV-1 group M radiation is almost exclusively based on gag and env gene sequences. Except for viruses of subtype B, there are very few full length reference sequences, thus making subtype assignments in regions other than gag an
Binding antibody against primary HIV-1 isolates induced in recipients of recombinant envelope glycoprotein HIV-1 candidate vaccines (MN/rgp120 and IIIB/rgp120).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:54. Unique Identifier : AIDSLINE MED/97927038; Gorse GJ; Patel GB; Mandava M; Berman PW; Belshe RB; Saint Louis University Health Sciences Center, St. Louis, MO. Fax:; (314) 771-3816.; Induction of binding antibody to native envelope glycoproteins of primary HIV-1 isolates by MN/- and IIIB/rgp120 vaccines in alum was evaluated. A flow cytometric indirect immunofluorescence assay was used to measure the binding of serum antibodies to PBL s infected with primary HIV-1 isolates. Sera were obtained befo
Bimodal HIV env DNA+protein immunization generates potent immune responses and protection against SHIV challenge.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:59. Unique Identifier : AIDSLINE MED/97927039; Liu MA; Letvin NL; Montefiori DC; Yasotomi Y; Perry HC; Davies ME; Lekutis C; Alroy M; Freed DL; Lord CI; Handt LK; Shiver JW; Merck Research Laboratories, West Point, PA. Fax: (215) 652-7320.; DNA vaccines provide an approach for inducing neutralizing antibody and cellular responses for a potential HIV vaccine. We have demonstrated potent, boostable, long-lived HIV-1 envelope Env)-specific CTL responses in rhesus monkeys following immunization with DNA plasmid encoding HIV-1 env. Following boosting with rec
Development of a CTL epitope-based vaccine for the treatment of HIV infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:60. Unique Identifier : AIDSLINE MED/97927040; Wentworth P; Sette A; Southwood S; del Guercio MF; Wong N; Kubo RT; Volenec J; Walker BD; Kalams S; Cotton D; Chesnut RW; Cytel Corporation, San Diego, CA. Fax: (619) 552-8801.; Our goal is to develop more effective immunotherapeutics for the treatment of HIV-1 infection by stimulating CTL immunity focused on multiple, conserved CTL epitopes. In order to accomplish this, we have developed a method to identify CTL epitopes derived from highly conserved regions of the HIV-1 virus. This multi-st
Expression of interferon-gamma by SIV increases attenuation and vaccine efficacy for juvenile and neonatal rhesus macaques.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:61. Unique Identifier : AIDSLINE MED/97927041; Yilma T; Ahmad S; Jones L; Giavedoni LD; International Laboratory of Molecular Biology for Tropical Disease; Agents, University of California, Davis, CA. Fax: (916) 752-1354.; We have developed recombinant SIVs expressing IFN-gamma SIV(HyIFN)) as a novel approach for enhancing the safety and efficacy of live attenuated vaccines for AIDS. Macaques vaccinated with SIV(HyIFN) have reduced pre- and post-challenge virus load compared to those vaccinated with SIV(deltanef).We now report that SIV(
Targeting of HIV-1 antigens for rapid intracellular degradation enhances CTL recognition and the induction of de novo CTL responses in vivo following immunization.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:62. Unique Identifier : AIDSLINE MED/97927042; Tobery TO; Siliciano RF; Johns Hopkins University School of Medicine, Baltimore, MD. Fax: 410); 955-0964.; CD8+ CTL have the ability to recognize and eliminate virally infected cells before new virions are produced within that cell. Therefore, a rapid and vigorous CD8+ CTL response, induced by vaccination, can, in principle, prevent disseminated infection in vaccinated individuals who are exposed to the relevant virus. The
A simple, systematic and unbiased approach to developing an HIV vaccine.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:63. Unique Identifier : AIDSLINE MED/97927043; Johnston SA; Sykes K; Departments of Medicine and Biochemistry, University of; Texas--Southwestern Medical Center, Dallas, TX. Fax: (214) 648-1450.; We present our progress on a simple, systematic and unbiased approach to developing an HIV vaccine. It is based on two recent technological advances: Genetic Immunization as a simple method of delivering and testing vaccines and Expression Library Immunization as a method to resolve the best vaccine candidates from a
Mucosal and systemic immunization using DNA and protein cochleates.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:64. Unique Identifier : AIDSLINE MED/97927044; Gould-Fogerite S; Zhang F; Kheiri M; Edghill-Smith Y; Wang Z; Brois D; Chen ZW; Scolpino A; Lu R; Mautone A; Feketeova E; Mannino RJ; Department of Laboratory Medicine and Pathology, UMDNJ, New Jersey; Medical School, Newark, NJ. Fax: (201) 982-7293.; Cochleate delivery vehicles are unique, highly stable, lyophilizable, lipid-based vaccine carrier and delivery formulations. Cochleates containing proteins, peptides or DNA are highly effective vaccines when given on mucosal surfaces or parenterally. Strong, long lasting, mucosal and circulating antibody responses are
Clinical and laboratory safety and initial efficacy studies with an autogenous HIV cellular/viral therapeutic vaccine (DROVAC) utilizing a Sendai virus envelope derived adjuvant (SDE).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:64. Unique Identifier : AIDSLINE MED/97927045; Gould-Fogerite S; Oleske J; Mannino RJ; Scolpino A; Holland B; Feketeova E; D'orlando D; Palumbo P; Chakraborty R; Denny T; University of Medicine and Dentistry, New Jersey Medical School,; Newark, NJ. Fax: (201) 982-7293.; DROVAC was composed of disrupted PBMC (cellular antigens) isolated from 10 ml WB and bound to a Sendai Virus Envelope (SDE) adjuvant. Eight patients, CDC classifications B1 to C3, have had sequential vaccines prepared at 6 wk. intervals (dose #1-3) with a fourth dose given 8-10 wks after the 3rd dose. Three patients r
Human-infecting forms of caprine arthritis-encephalitis virus CAEV) in HIV vaccine strategies.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:65. Unique Identifier : AIDSLINE MED/97927046; Douvas A; Cheevers WP; Ehresmann G; Garcia de la Torre I; Levine A; Xia L; Liu J; University of Southern California, School of Medicine/Hematology, Los; Angeles, CA. Fax: (213) 342-2874.; CAEV is a macrophage-tropic lentivirus causing arthritis, mastitis and encephalitis in goats. Our recent data demonstrate that novel variants (h-CAEV) infect humans, and generate immune cross-reactivity to HIV-1. Evidence for these forms, which are endemic in Mexico , includes: (a)
Neutralizing antibodies as a correlate of vaccine efficacy in the SHIV model.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:68. Unique Identifier : AIDSLINE MED/97927047; Montefiori DC; Earl PL; Moss B; Hu SL; Lewis M; VanCott TC; Birx DL; Wyand MS; Manson K; Shiver JW; Reimann KA; Letvin NL; Duke University Medical Center, Department of Surgery, Durham, NC.; Fax: (919) 684-4288.; The advent of chimeric simian-human immunodeficiency virus (SHIV) affords opportunities to assess HIV-1 vaccine efficacy and to identify correlates of protective immunity in an animal model. Titers of neutralizing antibodies against SHIV-HXB2 correlated with protection against intravenous SHIV-HXB2 challenge in macaqu
Protection against SHIV(IIIB) challenge by the "prime/boost" regimen.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:69. Unique Identifier : AIDSLINE MED/97927048; Hu SL; Klaniecki JE; Travis BM; Wrey T; Pennathur S; Thompson JL; Agy MB; Kuller L; Lu Y; Montefiori D; Morton WR; University of Washington, Seattle, WA. Fax: (206) 685-0305.; We previously showed that immunization with HIV-1(LAI) gp160 vaccines, in a recombinant virus priming and subunit protein boosting regimen, protected macaques against SHIV HXBc2 challenge. In the present study, we examined the role of (1) priming with live recombinant vaccinia virus vs. subunit antigens, (2) surface a
Results of vaginal challenge with pathogenic SIVmac in rhesus macaques immunized with SIV subunits by targeted iliac lymph node immunization or by vaginal inoculation with an attenuated SHIV.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:70. Unique Identifier : AIDSLINE MED/97927049; Miller CJ; Lehner T; Kiyono H; Kawabata S; McChesney MB; Lu X; Lu D; Roberts B; Lu Y; California Regional Primate Research Center, University of California,; Davis, CA. Fax: (916) 752-2880.; A total of nine mature female rhesus macaques were immunized 3 times with SIV envelope and core subunit antigens or whole-killed SIV by the targeted iliac lymph node immunization procedure. All the animals made strong serum IgG responses to the antigens. In addition, high levels of anti-SIV IgG were found in vaginal s
Quantitation of plasma and lymphoid tissue viral load in rhesus macaques immunized with an attenuated SIV vaccine.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:71. Unique Identifier : AIDSLINE MED/97927050; Connor RI; Dailey PJ; Montefiori D; Binley J; Moore J; Koup R; Ho D; Marx P; Aaron Diamond AIDS Research Center, New York, NY. Fax: (212) 725-1126.; Immunization of rhesus macaques with a nef-deleted strain of SIV SIVmac239deltanef) has been shown to protect against subsequent challenge with pathogenic strains of SIV. Despite these findings, the correlates of protective immunity remain poorly defined and detailed information on the kinetics of virus replication in
Outcome of rectal SIVsm challenge of macaques vaccinated with modified vaccinia Ankara (MVA) expressing SIVsm env and gag-pol.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:72. Unique Identifier : AIDSLINE MED/97927051; Biberfeld G; Thorstensson R; Nilsson C; Makitalo B; Sutter G; Akerblom L; Putkonen P; Swedish Institute for Infectious Disease Control, Stockholm, Sweden.; Fax: +46-8 735 4136.; Three groups of 4 cynomolgus macaques (n=12) were immunized im with 5x10(8) plaque forming units of MVA expressing SIVsm env gag-pol (MVA-SIV), one group at 0 and 3 months and the second group at 0, 3 and 8 months. The third group was given MVA-SIV at 0 and 3 months followed by native SIVgp 148 and rec SIVp27 in immun
Immunization of macaques with full-length SIV nucleocapsid mutant DNA.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:73. Unique Identifier : AIDSLINE MED/97927052; Gorelick R; Benveniste R; Lifson J; Rossio J; Bess J; Henderson L; Arthur LO; NCI-FCRDC, SAIC Frederick, Frederick, MD. Fax: (301) 846-5588.; The Zn(2+)-finger structures (CCHC) found in retroviral nucleocapsid (NC) proteins are necessary for packaging the retroviral genomic RNA during budding and maturation of the virus particle. Transfection of an SIV mutant lacking 4 amino acids at the beginning of the second zinc finger resulted in expression of non-inf
Characterisation of vaccine protection in macaques.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:74. Unique Identifier : AIDSLINE MED/97927053; Almond N; Wade-Evans A; Stebbings R; Walker B; Stott EJ; NIBSC, Herts, UK. Fax: +44 1707 649865.; We have used the SIV/macaque model to evaluate a number of alternative vaccine approaches in vivo. Live attenuated viruses fulfill the criteria required for an effective AIDS vaccine. However, their widespread use as a prophylactic vaccine is precluded by issues of safety. We have used the SIV/macaque model to charact
Lack of vaccine protection against experimental SHIV infection in rhesus macaques.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:75. Unique Identifier : AIDSLINE MED/97927054; Girard M; Barre-Sinoussi F; van der Ryst E; Verrier F; Moog C; Aubertin AM; Institut Pasteur, Paris, France. Fax: (33) 1 40 61 30 45.; To analyze immune correlates of protection from HIV infection, experiments were performed using the SHIV/macaque model. Three rhesus monkeys were repeatedly immunized with whole inactivated HIV-1 BX08 (a French clinical isolate grown in PBMC) in the presence of QS21, RIBI adjuvant, then incomplete Freund adjuvant. In
Vaccine-induced protection of rhesus monkeys after intravaginal challenge: an effect of antiviral cytotoxic T lymphocytes?: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:78. Unique Identifier : AIDSLINE MED/97927055; McChesney MB; Collins JR; Ringler DJ; Lu Y; Miller CJ; University of California-Davis, California Regional Primate Research; Center, Davis, CA. Fax: (916) 752-2880.; In order to determine if a previous infection with an intravaginally inoculated nonpathogenic SIV/HIV envelope chimeric virus (SHIV) could protect animals from vaginal challenge with pathogenic SIV, 5 animals were intravaginally inoculated twice with pathogenic SIVmac239. After challenge, all of the SHIV-immunized ani
Correlation of mucosal SIV env-specific CTL with protection in rhesus monkeys.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:79. Unique Identifier : AIDSLINE MED/97927056; Wilson LA; Trichel A; Xu K; Ohkawa S; Roberts D; Martin L; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA. Fax: 504); 893-1352.; Eleven monkeys were inoculated intracolonically by endoscopy with limiting doses of the pathogenic clone SIVmac239 (4) or its nonpathogenic derivative SIV17E-Fr (7). All animals were assayed for CTL at 8 weeks in the peripheral blood (PBL) and the jejunum lamina propria (LP). Mesenteric lymph nodes and jejunum intraep
Cellular immunity, mucosal challenge and highly attenuated SIV vaccines.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:80. Unique Identifier : AIDSLINE MED/97927057; Johnson RP; Gauduin MC; Glickman R; Yang J; Czajak S; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical School,; Southborough, MA. Fax: (508) 624-8172.; We analyzed the ability of CD8+ T cells from SIV239deltanef and delta3-infected animals to suppress SIV replication and investigated the relationship between SIV-specific CTL activity and protection against mucosal challenge in animals vaccinated with more highly attenuated SIV strains. CD8+ T lymphocytes from animals
Early loss of antigen induced IFNgamma with gradual increase in IL-6 in macaques infected with SIVmac251 as they progress towards AIDS.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:81. Unique Identifier : AIDSLINE MED/97927058; Villinger F; Brar SS; Mayne AE; Chikkala NF; Brice G; Ansari AA; Emory University School of Medicine, Atlanta, GA. Fax: (404) 778-50l6.; A reported shift from Th1 to Th2 type of immune responses correlating with progression towards disease in HIV-1 infected patients has been a subject of considerable debate. In order to better evaluate such a hypothesis, a group of 6 rhesus macaques was immunized with KLH, tetanus toxoid and live attenuated influenza A
Evolution of antibody responses during persistent lentivirus infection and development of protective immunity: variations on a common theme of maturation.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:82. Unique Identifier : AIDSLINE MED/97927059; Montelaro RC; Cole KS; Rowles JL; Hammond SA; Clements JE; Desrosiers RC; Murphey-Corb M; University of Pittsburgh, Pittsburgh, PA. Fax: (412) 383-8859.; Vaccine trials using various attenuated strains of SIV in monkeys have demonstrated that the development of broadly protective immunity typically requires a minimum of about 6 months, suggesting a necessary maturation of immune responses. To characterize the evolution of virus-specific antibody responses during this m
Viral diversity as a marker of disease progression in SIV infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:87. Unique Identifier : AIDSLINE MED/97927060; Haigwood NL; Misher LE; Goskink J; Montefiori D; Johnson P; Watson A; Seattle Biomedical Research Institute, Seattle, WA. Fax: (206); 284-0313.; As with HIV-1 infection of humans, disease outcome in SIV-infected macaques is not uniform. There are 4 outcomes with SIVsmE660 infection of M. mulatta: rapid progression to disease in less than 30 weeks (RP); progression in 30-70 weeks (P); slow progression in 70-104 weeks (SP); and no disease at greater than 104 wee
Attenuated SIV vaccines: degree of protection from homologous and heterologous challenge.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:88. Unique Identifier : AIDSLINE MED/97927061; Lewis MG; Novembre F; Desrosiers R; Lu Y; Montefiori D; Yalley-Ogunro J; Greenhouse J; Brennan T; Eddy G; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-7460.; Attenuated SIV vaccines have been shown to be very effective at inducing protective immune responses in macaques challenged with homologous pathogenic strains of SIV. We initiated a study to determine the degree of protection stimulated by attenuated viruses. Two strains of nef deleted SIV were evaluated: SIV(mac239de
Virological and immunological parameters in cynomolgus macaques infected with pathogenic or attenuated SIV: correlations with the outcome of a challenge with SHIV89.6P or SIVsmm(PBJ14)?: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:89. Unique Identifier : AIDSLINE MED/97927062; Rud EW; Vogel T; Sherring A; Bogdanovic D; Ko D; Brown J; Kim J; Parenteau M; Beausoleil N; Fournier J; National Laboratory for HIV Pathogenesis, Ottawa, Ontario, Canada.; Fax: (613) 957-7258. E-mail: erud@inet.hwc.ca.; AIMS: To determine the immune responses induced by infection of macaques with either an attenuated or pathogenic variant of SlVmac32H and ultimately to correlate these to the protection induced against subsequent heterologous challenge with either SHIV89.6P or with SIVsmm(PBJ14). METHODS: Three groups of 8 cynomolgus
Pathogenesis and prevention of SHIV disease.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:90. Unique Identifier : AIDSLINE MED/97927063; Narayan O; Stephens EB; Joag SV; Li Z; Atkinson RB; Foresman L; McClure HM; University of Kansas Medical Center, Kansas City, KS. Fax: (913); 588-5599.; SHIV(Ku-1) is a biologically-pure suspension of SHIV that is highly pathogenic in pigtailed macaques. The virus was derived by sequential passage of the molecular construct of SIV(mac)239XHIV-1-HxB2 through bone marrow of pigtailed macaques Joag et al J. Virol., 1996). The virus has numerous genomic changes that disti
Correlates of immunity to HIV-1 assessed in hu-PBL-SCID mice.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:94. Unique Identifier : AIDSLINE MED/97927065; Mosier DE; Scripps Research Institute, La Jolla, CA. Fax: (619) 784-9190.; SCID mice repopulated with human peripheral blood mononuclear cells (hu-PBL-SCID mice) have proven useful for assessing effective immunization of normal volunteers with candidate vaccines, and for passive transfer of cytotoxic T lymphocytes and human monoclonal antibodies to assess the relative importance of cellular
Prevention of HIV infection in thy/liv-SCID-hu mice by acute treatment with multi-drug therapy or IL-10.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:95. Unique Identifier : AIDSLINE MED/97927066; Goldstein H; Kollmann TR; Pettoello-Mantovani M; Katopodis NF; Gibbons C; Yurasov S; Albert Einstein College of Medicine, Bronx, NY. Fax: (718) 430-8972.; Modifications we introduced into the implantation of human fetal thymus and liver under the kidney capsules of SCID mice thy/liv-SCID-hu mice) resulted in the population of the peripheral lymphoid compartment of these mice with high numbers of human T cells. After inoculation with HIV, extensive HIV infection was dete
Development of a hu-PBL-SCID/beige mouse model for the evaluation of HIV protective immunity.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:96. Unique Identifier : AIDSLINE MED/97927067; Chang LJ; University of Alberta, Department of Medical Microbiology and; Immunology, Edmonton, Alberta, Canada. Fax: (403) 492-9828.; The evaluation of HIV protective immunity in humans is critical to the understanding of host immune responses and the development of an effective immunization strategy against HIV infection. Vaccine-induced anti-HIV immunity can be tested in non-human primates like chimpanzees, or studied in monkeys using SIV as a mod
Transgenic mouse models of HIV-1 infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:98. Unique Identifier : AIDSLINE MED/97927069; Jolicoeur P; Kay DG; Cool M; Colombi S; Jothy S; Wells T; Hanna Z; Clinical Research Institute of Montreal, Montreal, Quebec, Canada.; Fax: (514) 987-5794.; We have generated transgenic (Tg) founders which express the complete NL4-3 HIV-1 coding sequences in CD4+ T cells and in cells of the macrophage/dendritic lineage. Mice born from these founders developed a very severe AIDS-like disease leading to early death. These mice were very small as compared to non-Tg littermat
Human rhinovirus 14:HIV-1(MN) V3 loop chimeras induce potent neutralizing antibody responses against HIV-1.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:106 (Poster 1). Unique Identifier : AIDSLINE MED/97927071; Ferstandig Arnold G; Smith AD; Chen AA; Geisler SC; Resnick DA; Roy BM; Arnold E; Center for Advanced Biotechnology & Medicine/Rutgers University,; Piscataway, NJ. Fax: (908) 235-5788.; With the aim of developing a useful AIDS vaccine or vaccine component, we have produced a library of chimeric viruses in which the V3 loop of the MN strain of HIV-1 is displayed in many conformations on the surface of human rhinovirus 14 (HRV14). The V3 loop sequence was inserted into a naturally immunogenic site of H
Construction of multi component DNA immunization cassettes using HIV-1 accessory genes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:107 (Poster 2). Unique Identifier : AIDSLINE MED/97927072; Ayyavoo V; Thandavarayan N; Boyer J; Sundarasamy M; Sagar K; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia, PA. Fax: (215) 573-9436.; Delivery of genetic expression cassettes into animals can effectively induce both humoral and cellular immunity to the expressed gene. Previously, we used this strategy for structural and enzymatic proteins of HIV-1 in mice, non human primates and in humans. However, the use of the accessory genes as immunotherapeutic
Vaccinia virus strain Modified Virus Ankara: characterisation of cytokine receptor profile, virological features, and use as an immunological reagent.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:108 (Poster 3). Unique Identifier : AIDSLINE MED/97927073; Blanchard T; Alcami A; Becker M; Hanke T; Andrea P; Gould K; Britton W; Anderton P; Rowland-Jones S; McMichael AJ; Smith GL; Sir William Dunn School of Pathology, Oxford, England. Fax: +44 1865; 275501.; Modified Virus Ankara (MVA) is an attenuated strain of vaccinia virus derived by serial passage through chick cells. MVA was administered to greater than 120,000 individuals towards the end of the smallpox eradication campaign without any significant adverse effects. We have sought to establish the reasons for the saf
The identification of "HIV-1-mimic" peptides using antibodies from the sera of HIV-1 infected, long-term non-progressors.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:109 (Poster 4). Unique Identifier : AIDSLINE MED/97927074; Bonnycastle L; Brown K; Kim S; Scott J; Institute of Molecular Biology & Biochemistry and Department of; Biological Sciences, Simon Fraser University, Burnaby, B.C., Canada.; Fax: (604) 291-5583. E-mail: lori_bonnycastle@sfu.ca.; Our goals in this project are twofold. In the short term, we wish to identify peptides that react with Abs that are specific to HIV-1 infection. Over the longer term, we hope to determine whether the antibodies recognized by such peptides will neutralize HIV-1 infectivity. We screened a panel of sixteen, phage-display
Live attenuated VEE virus vectors expressing HIV-1 MA/CA proteins elicit long lived humoral and cellular immune responses in mice.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:110 (Poster 5). Unique Identifier : AIDSLINE MED/97927075; Caley IJ; Davis NL; Betts MR; Irlbeck DM; Frelinger JA; Swanstrom RI; Johnston RE; University of North Carolina, Department of Microbiology and; Immunology, Chapel Hill, NC. Fax: (919) 962-8103.; Attenuated cDNA clones of Venezuelan equine encephalitis virus VEE) were engineered to contain a second subgenomic promoter at either the 3 end of the non-structural gene region, or immediately downstream of the E1 glycoprotein gene. The matrix/capsid (MA/CA) coding domain of HIV-1 gag was cloned under the control of
Identification of conserved regions of HIV-1 which serve as ligands to HLA-A2 and HLA-B27.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:111 (Poster 6). Unique Identifier : AIDSLINE MED/97927076; Schafer J; George J; Jesdale W; Kouttab N; Mayer K; Lieberman J; De Groot AS; TB/HIV Research Laboratory, International Health Institute, Brown; University, Providence, RI. Fax: (401) 863-1243. E-mail:; Anne_DeGroot@Brown.edu.; A successful HIV-1 vaccine will need to induce protective CD8+ CTL responses against a wide array of diverse HIV-1 isolates. This study was undertaken to identify new HLA ligands from HIV-1 which are highly conserved across HIV-1 clades and which may serve to induce cross-reactive CTLs. The computer algorithm EpiMatri
Synthesis of multidimensional contiguous peptide arrays of ten HIV-1 proteins.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:112 (Poster 7). Unique Identifier : AIDSLINE MED/97927077; Dixon JD; Purification Systems, Inc., Royal Oak, MI. Fax: (810) 288-1241.; Recent advances in multiple peptide synthesis instrumentation allow the rapid production of synthetic peptides useful in vaccine development and characterization of immune responses. A significant problem is the amount of time required for post-synthesis analytical purification and analysis of the resulting peptides.
Cultured blood dendritic cells have potent HIV-1 antigen-presenting capacity for T lymphocytes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:113 (Poster 8). Unique Identifier : AIDSLINE MED/97927078; Fan Z; Huang X; Zheng L; Wilson C; Borowski L; Liebmann J; Margolick J; Gupta P; Rinaldo C; University of Pittsburgh, Department of Infectious Diseases and; Microbiology, Pittsburgh, PA. Fax: (412) 624-4953.; Dendritic cells are potent antigen-presenting cells (APC) for naive and memory T lymphocytes. We studied the APC function of DC from HIV-1 infected and uninfected subjects that were derived from monocyte-depleted PBMC by culture in hIL4 and hGM-CSF. The morphology and phenotype were similar for DC cultured from seropo
Mice and rhesus macaque females immunized with HIV-1 peptides conjugated to brucella abortus(BA) develop anti-peptide serum and mucosal antibody responses.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:114 (Poster 9). Unique Identifier : AIDSLINE MED/97927079; Golding B; Scott DE; Matthews N; Levi L; Inman J; Golding H; Laboratory of Plasma Derivatives, Division of Hematology, Center for; Biological Evaluation and Research, US Food and Drug Administration,; NIAID, NIH, Bethesda, MD. Fax: (301) 402-2780.; The rate of heterosexual transmission of HIV-1 to women is increasing. This is probably taking place at mucosal sites particularly the vagina, but infection following rectal and oral sex is also possible. Protection at these sites requires induction of HIV-1-specific antibody secretion and cytotoxic T cells (CTL). Pre
A recombinant BCG vector-based vaccine for HIV-1.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:115 (Poster 10). Unique Identifier : AIDSLINE MED/97927080; Honda M; Someya K; Nakasone T; Matsuo K; Ando S; Ami Y; Sinohara K; Yosizaki H; Nakasatomi T; Okamoto Y; Sugiura W; Lu Y; Yamazaki S; AIDS Research Center, National Institute of Infectious Diseases,; Tokyo, Japan. Fax: +81 -3-5285-1150.; We immunized 10 cynomolgus monkeys with a recombinant Mycobacterium bovis BCG (BCG) vector-based vaccine for HIV-1 rBCG-V3J1), which was constructed to express and secrete a chimeric protein consisting of V3 principal neutralizing epitope of Japanese consensus HIV-1 in alpha-antigen protein. Neutralizing antibody acti
Engineering of immune responses to DNA immunization via co-delivery of costimulatory molecule genes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:117 (Poster 12). Unique Identifier : AIDSLINE MED/97927082; Kim JJ; Bagarazzi ML; Hu Y; Trivedi N; Chattergoon MA; Dang K; Agadjanyan MA; Mahalingam S; Boyer JD; Wang B; Weiner DB; University of Pennsylvania, Philadelphia, PA. Fax: (215) 573-9436.; Costimulatory molecules play an important role in the induction of T cell-mediated immune responses. Effective T cell activation by APC requires two stimuli: the first signal originates from the binding of antigen-MHC and T cell receptor molecules which confers specificity. The second signal comes from the costimulato
The effect of dose and adjuvant on immunization with a whole killed gp120-depleted HIV-1 immunogen in a murine model for prophylactic vaccination.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:118 (Poster 13). Unique Identifier : AIDSLINE MED/97927083; Lanza P; Moss RB; Giermakowska W; Richieri SP; Salk P; Jensen FC; Carlo DJ; Immune Response Corp., Carlsbad, CA. Fax: (760) 431-8636.; Protective immunity involves a dynamic balance between humoral and cellular immune responses. In this study we used a murine model to examine the effect of dose and adjuvant of an HIV-1 Immunogen on HIV-1 specific immune responses. C57BI/6 mice were divided in three treatment groups. Animals were immunized SC with eit
Induction of an HIV-specific immune response in baboons using an HIV-2 expression library vaccine.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:119 (Poster 14). Unique Identifier : AIDSLINE MED/97927084; Locher CP; Sykes K; Blackbourn DJ; Chanh T; Trevino S; Murthy KK; Barnett SW; Johnston SA; Levy JA; Division of Hematology/Oncology, Department of Medicine, University of; California, San Francisco, CA. Fax: (415) 476-8365.; Previous studies showed that vaccination using expression libraries has the potential to protect mice against infection by Mycoplasma and Mycobacterium. Moreover, gene libraries provide the greatest number of antigens presented to the immune system without the use of an attenuated infectious agent. To extend these obs
QS-21 is effective in boosting anti-HIV-1 env antibody responses induced by DNA immunization.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:120 (Poster 15). Unique Identifier : AIDSLINE MED/97927085; Wang S; Manning S; Kensil C; Lu S; University of Massachusetts Medical Center, Worcester, MA. Fax: 508); 856-5981.; Raising a higher and more persistent immune response is critical in developing a DNA-based vaccine against HIV-1 infections. One potential method of optimization is the use of an immunological adjuvant with the DNA-based vaccines. QS-21 was selected for its known adjuvant effect for subunit vaccines. Groups of 6-8 wee
Antigen delivery systems and routes of immunization for induction of virus-specific cytotoxic lymphocytes (CTL).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:121 (Poster 16). Unique Identifier : AIDSLINE MED/97927086; Nguyen HH; Moldoveanu Z; Novak M; Kiyono H; McGhee JR; Mestecky J; University of Alabama at Birmingham, Birmingham, AL. Fax: (205); 934-3894.; For induction of CTL responses, an important effector mechanism in the elimination of virus infected cells, different antigen delivery systems were used. We demonstrate that intraperitoneal immunization with formalin-inactivated influenza virus (50 micrograms/mouse) incorporated into poly(DL-lactide-co-glycolide)(DL-P
Cytokine adjuvant for DNA vaccine against HIV-1 infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:122 (Poster 17). Unique Identifier : AIDSLINE MED/97927087; Okuda K; Sasaki S; Wharen B; Fukushima J; Department of Bacteriology, Yokohama City University School of; Medicine, Kanagawa, Japan. Fax: +81-45-787-2509.; To activate HIV-1-specific cell-mediated immune responses by using DNA vaccine is one of the most important issues for developing a new HIV-1 vaccine. In this study we used various expression plasmids of cytokines to modify the immunogenicity of this vaccine. To use expression plasmids has advantages for releasing pro
DNA priming and rgp160 boosting elicit antibody which neutralizes T-cell line-adapted strains, but not primary isolates, of HIV-1.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:124 (Poster 19). Unique Identifier : AIDSLINE MED/97927088; Richmond JF; Lu S; Santoro JC; Weng J; Montefiori DC; Robinson HL; Department of Pathology, University of Massachusetts Medical Center,; Worcester, MA. Fax: (508) 856-5780.; Rabbits were primed by gene-gun immunization with a plasmid, or combination of plasmids, expressing various forms of HIV-1-HXB-2 Env. Rabbits primed with full-length gp160 (Env) failed to develop antibodies, while rabbits primed with a full-length Env combined with gp120 and gp140 forms of Env (Env++), or a plasmid ex
Screening of HIV-1 env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:125 (Poster 20). Unique Identifier : AIDSLINE MED/97927089; Richmond JF; Mustafa F; Lu S; Fenyo EM; Hurwitz JL; Montefiori DC; Robinson HL; Departments of Pathology and Medicine, University of Massachusetts; Medical School, Worcester, MA. Fax: (508) 856-5780.; HIV-1 envelopes from two series of primary isolates, from JR-FL and BaL (prototypic monocyte/macrophage tropic viruses) and from HXB-2 (a prototypic T-cell-line-adapted virus) have been screened for their ability to elicit neutralizing antibody to HIV-1. Rabbits were primed by gene gun inoculation with plasmids expres
Water-in-oil-in-water formulation with block copolymer adjuvant P1005 enhances humoral responses to HIV-1 envelope protein gp160.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:126 (Poster 21). Unique Identifier : AIDSLINE MED/97927090; Ruhadze EN; Olsen MR; Bond KB; Newman MJ; Hunter RL; McNicholl JM; Emory University School of Medicine, Atlanta, GA. Fax: (404) 639-2108.; Vaccine delivery systems containing block copolymer adjuvant P1005 have been shown to be effective in the induction of secretory IgA and systemic IgG antigen-specific responses. We evaluated the secretory IgA and serum IgG antibody responses in groups of female Balb/c mice immunized orally or subcutaneously s.c.) with
Immunomodulation of AIDS DNA vaccine toward strong CTL activity.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:127 (Poster 22). Unique Identifier : AIDSLINE MED/97927091; Sasaki S; Hamajima K; Fukushima J; Kaneko T; Kawamoto S; Mohri H; Okubo T; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Kanagawa, Japan. Fax: +8 1-45-787-2509.; The most beneficial point of DNA vaccination is believed that induction of stronger CTL activity than that of the peptide vaccines. Potent cytotoxicity against HIV-infected lymphocytes is essential to provide protective immunity on the vaccinee. We therefore examined whether immunomodulatory compounds enhance CTL acti
Isolation of peptides that bind to anti-HIV antibodies.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:128 (Poster 23). Unique Identifier : AIDSLINE MED/97927092; Zwick M; Bonnycastle L; Leong E; Brown K; Kim S; Mehroke J; Noren C; Noren K; Scott JK; Institute of Molecular Biology & Biochemistry and Department of; Biological Sciences, Simon Fraser University, Burnaby, BC, Canada.; Fax: (604) 291-5583. E-mail: jkscott@sfu.ca.; We are in the process of isolating peptides that bind human anti-HIV antibodies (Abs) in an effort to discover new leads for immunological study. Initially, several phage-displayed peptide libraries were screened with the monoclonal Ab Loop2. This Ab recognizes a constrained peptide corresponding to the V3 loop of gp1
Preclinical immunogenicity studies with Thai E rgp120/MF59 vaccine.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:129 (Poster 24). Unique Identifier : AIDSLINE MED/97927093; De Sun Y; Cuadra L; Higgins K; Mascola J; Steimer K; Sinangil F; Chiron Corporation, Emeryville, CA. Fax: (510) 923-6918.; Thai E rgp120 subunit protein (rgp120(CM235cons)) was derived from the HIV-1(CM235) isolate recovered from a Thai individual early in the epidemic in Thailand . The V3 of the recombinant Env has been mutated at two amino acids to match the Thai E V3 consensus sequence. This protei
Dendritic cell vaccine models allow for identification of novel T cell epitopes in HIV-1 nef.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:130 (Poster 25). Unique Identifier : AIDSLINE MED/97927094; Wilson CC; Rinaldo CR; Tueting T; Martin D; Farhood H; Lotze MT; Storkus WJ; University of Pittsburgh Medical Center, Pittsburgh, PA. Fax: 412); 624-1172.; An in vitro vaccine model for HIV-1 was developed using cultured DC as stimulators and naive T cells from HIV-1 seronegative donors as responders. DC cultured from nonadherent PBMC in GM-CSF and IL-4 for 5-10 days were pulsed with recombinant Nef antigen or were transfected with the HIV-1 nef gene. Human IL-12 and IFN
A particulate HIV-vaccine: from concepts to field trials.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:131 (Poster 26). Unique Identifier : AIDSLINE MED/97927095; Wagner R; Deml L; Notka F; Yiming S; Wolf H; Institute for Medical Microbiology and Hygiene, Regensburg, Germany.; Fax: .49 94l 944 6402.; Recombinant HIV-1 virus-like particles (VLPs) have been constructed allowing the presentation of either size limited CTL and Th-epitopes or the delivery of oligomeric HIV-1 envelope derivatives to the immune system. Depending on the formulation, recombinant VLPs generated both, neutralizing antibodies and an HIV-speci
Enhanced pathogenicity of SHIV HXBc2 following whole blood passage in Macaca nemestrina.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:132 (Poster 27). Unique Identifier : AIDSLINE MED/97927096; Agy MB; Thompson JL; Coon EM; Kuller L; Anderson DM; Hu SL; Morton WR; Regional Primate Research Center, University of Washington, Seattle,; WA. Fax: (206) 685-0305.; The lack of a suitable nonhuman primate model to examine HIV-1 pathogenicity and to evaluate HIV-1-specific infection intervention strategies has led to the construction and use of chimeric SIV-HIV viruses (SHIV). We have titered SHIV HXBc2 chimera in M. nemestrina and used this virus to challenge HIV-1-env vaccinated
IL-12 enhances T-helper 1 responses to recombinant vaccinia-SIV vaccines in rhesus macaques, but does not influence the outcome of SIV(251) challenge.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:134 (Poster 29). Unique Identifier : AIDSLINE MED/97927098; Benson J; Chougnet C; Guroff M; Shearer G; Paoletti E; Tartaglia J; Markham P; Cranage M; Franchini G; National Cancer Institute, Bethesda, MD. Fax: (301) 496-8394.; Interleukin 12 (IL-12) and interleukin 2 ( IL-2 ) are both potent regulators of immune responses. Each is associated with the T-Helper 1 subset of reactive T cells. The absence or suppression of these cytokines at the initiation of an immune response to antigen(s) will r
Evolution of envelope-specific antibody responses to experimental infection with SIV and its association with the development of protective immunity.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:136 (Poster 31). Unique Identifier : AIDSLINE MED/97927100; Cole KS; Rowles JL; Murphey-Corb M; Unangst T; Clements JE; Robinson J; Wyand M; Desrosiers RC; Montelaro RC; University of Pittsburgh School of Medicine, Pittsburgh, PA. Fax: 412); 383-8859.; To characterize the evolution of protective immunity in monkeys experimentally infected with various attenuated strains of SIV, we used a comprehensive panel of serological assays to assess the progression of viral envelope-specific antibodies. Results of these studies reveal remarkable differences between protective
Quantification of SIV RNA in tissues and mononuclear cells (MC) using a branched DNA (bDNA) assay: performance characteristics and comparison with plasma viral load.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:137 (Poster 32). Unique Identifier : AIDSLINE MED/97927101; Dailey PJ; Booth J; Wingfield C; Johnson P; Chiron Diagnostics, Emeryville, CA. Fax: (510) 655-7733.; We evaluated the feasibility of quantitating viral load (SIV RNA) in lymphoid tissues and cells using a bDNA assay for SIV RNA. Quantification of viral load in tissues and MCs involves unique challenges including: 1) insuring reproducible, quantitative recovery of nucleic acid after extraction; 2) selection of an appr
A recombinant prime, peptide boost strategy to vaccinate rhesus monkeys against SHIV.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:138 (Poster 33). Unique Identifier : AIDSLINE MED/97927102; Davis D; Morein B; Akerblom L; Teeuwsen VJ; van Gils M; Bogers WM; Heeney JL; Institute of Tropical Medicine, Antwerp, Belgium. Fax: 32 3 247 63 33.; Sterile immunity was induced in rhesus monkeys against challenge with SHIV SF13 using an ISCOM based strategy. The vaccine formulation and immunization schedule would be acceptable for further study in human clinical trials. Immune responses were primed by i.m. injections of 30 micrograms of Chiron s recombinant HIV-1
Immune responses induced by Accell gene gun SIV DNA immunization reduce viremia and delay CD4 decline in rhesus macaques challenged with a heterologous SIV isolate.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:139 (Poster 34). Unique Identifier : AIDSLINE MED/97927103; Heydenburg Fuller D; Simpson L; Stefano Cole K; Monterlero R; Haynes J; Murphy-Corb M; Mazarra G; Geniva, Middleton, WI. Fax: (608) 836-5188.; Direct intracellular epidermal DNA vaccination using the Accell gene gun has been shown to result in the induction of humoral, cellular, and protective immune responses in laboratory animals. We evaluated the ability of gene gun DNA immunization alone or in combination with recombinant vaccinia vectors to elicit a pro
Humoral and cellular immune response generated by plasmid-DNA vaccination of macaque monkeys.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:140 (Poster 35). Unique Identifier : AIDSLINE MED/97927104; NiBlein T; Dittmer U; Oesterle R; Stahl-Hennig C; Luke W; Jurkiewicz E; Hammerschmidt W; Hunsmann G; Petry H; German Primate Centre, Department for Virology and Immunology,; Goettingen, Germany. Fax: +49-551-3851-184.; We have immunised four cynomolgus macaques (Macaca fascicularis) by intramuscular injection of two different expression vectors containing the env gene of SIVmac239. In both vectors (#1, #2) expression of the env gene is driven by the CMV promotor. DNA vaccine #
Urethral challenge of male rhesus macaques immunized with inactivated SIV encapsulated in biodegradable microspheres.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:141 (Poster 36). Unique Identifier : AIDSLINE MED/97927105; Ishizaka ST; Israel Z; Gettie A; Staas J; Gilley R; Eldridge J; Marx P; Wyeth-Lederle Vaccines and Pediatrics, Pearl River, NY. Fax: 914); 732-5585.; To address the potential of mucosal immunity in preventing SIV infection across the genital mucosa, a group of 8 male rhesus macaques was immunized with inactivated, sucrose gradient-purified, rhesus PBMC-grown SIVmac239 encapsulated in biodegradable poly-DL-lactide-co-glycolide microspheres. Two intramuscular (IM) pr
Cellular and humoral immune responses in SIV microsphere immunized and vaginally challenged female rhesus macaques.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:142 (Poster 37). Unique Identifier : AIDSLINE MED/97927106; Israel ZR; Gettie A; Ishizaka ST; Staas JK; Gilley RM; Marx PA; Eldridge JH; Wyeth-Lederle Vaccines and Pediatrics, Pearl River, NY. Fax: 914); 732-5585.; Our previous study demonstrated that three of four female rhesus macaques intramuscularly primed and mucosally boosted with formalin inactivated SIV in biodegradable microspheres were protected against 4 sequential intra-vaginal challenges with homologous virus. However, both vaccine and challenge stocks were prepared
Infection of baboons with a SHIV containing an HIV-1 Thai subtype E envelope: an animal model for HIV-1 subtype E vaccine studies.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:143 (Poster 38). Unique Identifier : AIDSLINE MED/97927107; Klinger JM; Legg H; Higgins K; Brasky KM; Himathongkham S; Luciw PA; Barnett SW; Chiron Corporation, Emeryville, CA. Fax: (510) 923-2918.; The SHIV model provides an avenue for assessing the prophylactic properties of HIV-1 envelope-based vaccines in non-human primates. Recently, attention has focused on the development of HIV vaccines that would be effective in areas of the world where non-subtype B HIV-1 strains predominate. One such effort at Chiron h
Vaccine evaluation studies of replication-defective SIV(sm)B7.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:144 (Poster 39). Unique Identifier : AIDSLINE MED/97927108; Kraiselburd EN; Salaman A; Beltran M; Rivera M; Oliver J; Rodriguez A; Martinez I; Kessler M; Knezevich M; Bilka M; Montefiori D; University of Puerto Rico, Medical Science Campus, San Juan, PR. Fax:; (787) 764-4325.; Non-infectious virus-like particles of SIV(sm)B7 that expresses env and gag gene products but are defective in pol and vpx/vpr were assessed for their ability to induce protective immunity against infection with pathogenic SIVsmE660 in rhesus macaques. Animals were immunized in three groups: group A was primed with ce
CD8 antiviral activity: induction by immunization with NYVAC-SIV recombinant and influence on disease progression.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:145 (Poster 40). Unique Identifier : AIDSLINE MED/97927109; Leno M; Carter L; Markham P; Benson J; Franchini G; Robert-Guroff M; NCI, Basic Research Laboratory, Bethesda, MD. Fax: (301) 496-8394.; To determine if CD8 antiviral activity (CAA) is induced in rhesus macaques by immunization with attenuated vaccinia virus NYVAC)-SIV recombinants and to assess whether CAA is correlated with plasma RNA levels and outcome upon challenge, 5 groups of 8 macaques were inoculated 4 times intramuscularly with NYVAC-SIV reco
Genetic analysis of functional domains of SIV Nef.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:146 (Poster 41). Unique Identifier : AIDSLINE MED/97927110; Luciw PA; Khan I; Sawai ET; Mandell CP; Cheng-Mayer C; University of California, Department of Medical Pathology, Davis, CA.; Fax: (916) 752-4548.; The nef gene of HIV and SIV is dispensable for viral replication in vitro; however, this gene is essential for high virus load and progression to AIDS in SIV-infected rhesus macaques. Several in vitro properties of Nef, i.e. CD4 receptor down-regulation, T-cell activation, and enhancement of virion infectivity have be
SHIV infection and fatal immunodeficiency in macaques.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:147 (Poster 42). Unique Identifier : AIDSLINE MED/97927111; Luciw PA; Mandell C; Marthas M; Harouse J; Marx P; Cheng-Mayer C; University of California, Department of Medical Pathology, Davis, CA.; Fax: (916) 752-4548.; SIV/HIV-1 (SHIV) chimeric clones, constructed by substituting the env gene of the pathogenic clone SIVmac239 with the env gene from HIV-1 clones, establish persistent infection in juvenile and adult rhesus macaques. SHIV(SF33) contains the tat, rev, and env genes of the cytopathic, T-cell line tropic clone HIV-1(SF33)
SIV-interleukin-2 vector causes fatal disease in macaques.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:148 (Poster 43). Unique Identifier : AIDSLINE MED/97927112; Luciw PA; Mandell CP; University of California, Department of Medical Pathology, Davis, CA.; Fax: (916) 752-4548.; With the aims of (i) better understanding the role of cytokines in SIV infection and (ii) potentially influencing anti-viral immune responses, we have genetically engineered a clone of SIVmac into a replication-competent vector for expression of interleukin-2 ( IL-2 ), w
Immunization against SIVmne in macaques using naked DNA vaccines.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:149 (Poster 44). Unique Identifier : AIDSLINE MED/97927113; Mossman SP; Pierce CC; Morton WR; Benveniste RE; Hu SL; Robertson MN; Haigwood NL; University of Washington, Regional Primate Research Center, Seattle,; WA. Fax: (206) 284-0313.; We are evaluating the efficacy of naked DNA vaccination against SIV in macaques as a sole immunogen and as a priming agent in combination with recombinant protein boosts. We are utilizing the SIVmne/M. fascicularis model to compare the immune responses and degree of protection from challenge elicited by DNA immunizati
New immunoassay procedure to quantitate infectious SIV.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:150 (Poster 45). Unique Identifier : AIDSLINE MED/97927114; Prakash K; Stefanski M; Arthos J; Quality Biological, Inc., Gaithersburg, MD. Fax: (301) 840-5450.; Currently, no kit is commercially available for the detection of the gp130 env protein of SIV. We have designed and developed a quick, sensitive, and accurate method to quantitatively assay the SIV env protein. The testing protocol consisted of a simple ELISA format and the plates used in the immunoassay were coated w
Effect of CD8 cells on replication of a superchallenged SHIV in macaque monkeys.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:151 (Poster 46). Unique Identifier : AIDSLINE MED/97927115; Shibata R; Matano T; Siemon C; Connors M; Lane HC; Martin MA; Laboratory of Molecular Microbiology, NIAID/NIH, Bethesda, MD. Fax:; (301)402-0226.; We have recently reported (Matano et al., 4th conference on Retroviruses and Opportunistic Infections) that administration of an anti-CD8 monoclonal antibody to macaques transiently depleted CD8 cells in peripheral blood and in lymph nodes. Antibody treatment prior to virus inoculation resulted in sustained high virus
Protection of rhesus macaques from homologous and heterologous SHIV challenge using oligomeric gp160.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:152 (Poster 47). Unique Identifier : AIDSLINE MED/97927116; VanCott TC; Lewis M; Kaminski R; Mascola J; Kalyanaraman V; Pragman S; Frampton L; Yalley-Ogunro J; Greenhouse J; Lu Y; Jenkins S; Richardson C; Ulrich T; Wassef N; Alving C; Lowell G; Birx D; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-4177.; Protection of rhesus macaques from i.v. challenge with SHIV(HXBc2) was evaluated using affinity purified, oligomeric gp160 (ogp160-IIIB) or monomeric gp120-IIIB formulated with alhydrogel, monophosphoryl lipid A (MPL) or polyphosphazene. Previous studies in rabbits demonstrated the ability of ogp160 formulated in MPL
Infection of cats with FIV by injection with cloned proviral DNA.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:153 (Poster 48). Unique Identifier : AIDSLINE MED/97927117; Sparger EE; Louie H; Ziomeck AM; Luciw PA; Department of Veterinary Medicine and Epidemiology, University of; California, Davis, CA. Fax: (916) 752-0414.; Establishment of infection of animals with a viral clone is important for investigating viral determinants of pathogenesis and monitoring sequence changes in the viral genome in vivo, and may find utility as a means of immunization with live-attenuated virus. To test the efficiency of intramuscular (IM) injection of c
An FIV LTR mutant virus is attenuated in vivo and produces protective immunity against challenge with wild type FIV.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:154 (Poster 49). Unique Identifier : AIDSLINE MED/97927118; Sparger EE; Louie H; Ziomek AM; Luciw PA; Bigornia L; Department of Medicine and Epidemiology, School of Veterinary; Medicine, University of California, Davis, CA. Fax: (916) 752-0414.; AP-1 and ATF transcriptional elements within the U3 domain of the FIV long terminal repeat (LTR) serve as targets of cellular activation pathways and may regulate virus replication. To assess the role of these sites in virus replication, mutant proviruses pSVdeltaAP1, pSVdeltaATF, or pSVdeltaAP1/ATF) were created by r
Identification of candidate HLA-A11 cytotoxic T lymphocyte epitopes within HIV-1 subtype E.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:156 (Poster 51). Unique Identifier : AIDSLINE MED/97927120; Bond KB; Pau CP; Malegam JY; DeGroot A; Szu E; Hodge TW; Mastro TD; Limpakarnjanarat K; Stephens H; McNicholl JM; Centers for Disease Control and Prevention, Atlanta, GA. Fax: 404); 639-2108.; In Thailand the HIV-1 epidemic is dominated by envelope subtype E. HLA-A11 is a common allele in Thailand (30-50%), but is found in increased frequency in northern Thai female sex workers highly HIV exposed but persistently seronegative (HEPS). As HIV-specific class I-restricted
Optimization of in vitro stimulation strategies for induction of HIV-1 specific cytotoxic T lymphocytes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:157 (Poster 52). Unique Identifier : AIDSLINE MED/97927121; Cox JH; Sapan C; Lynch J; Birx DL; Robb ML; SRA Technologies Inc., Rockville, MD. Fax: (301) 548-2600.; Cytotoxic T lymphocytes (CTL) are an important component of the protective immune response elicited after infection with HIV. Vaccines developed to induce HIV-1 specific CTL responses are being tested worldwide and require a reproducible, convenient method of detecting HIV-1 specific CTL responses. Peripheral blood mo
Neutralization of the HIV-1 primary isolate JR-FL by human mAbs correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:158 (Poster 53). Unique Identifier : AIDSLINE MED/97927122; Fouts TR; Binley JM; Trkola A; Robinson JE; Moore JP; Aaron Diamond AIDS Research Center, New York, NY. Fax: (212) 725-1126.; To test whether antibodies that are neutralizing or nonneutralizing for HIV-1 primary isolates can be distinguished by their affinities for the oligomeric envelope glycoproteins, we selected HIV-1(JR-FL) as a model primary virus and panel of 13 human mAbs and evaluated three parameters: (1) half-maximal binding to rec
Differential suppression of HIV-1 by CD8+ T cells.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:159 (Poster 54). Unique Identifier : AIDSLINE MED/97927123; Chen Y; Dampf D; Kulka K; Saha K; Chen M; Gupta P; Department of Infectious Diseases and Microbiology, University of; Pittsburgh, Graduate School of Public Health, Pittsburgh, PA.; Fax:(412) 624-4953.; Using a semiquantitative assay the antiviral response of CD8+ T cells was found to be 5-100 fold greater against a slow replicating non-syncytia inducing (Slow/NSI) virus as compared to a fast replicating syncytia inducing (Fast/SI) virus. This differential activity was demonstrated against primary HIV-1 isolates, lab
Neutralization of HIV-1 primary isolates by polyclonal and monoclonal human antibodies.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:160 (Poster 55). Unique Identifier : AIDSLINE MED/97927124; Hioe C; Xu S; Chigurupati P; Burda S; Williams C; Gorny M; Zolla-Pazner S; New York University Medical Center, New York, NY. Fax: (212) 951-6321.; To examine Ab-mediated neutralization of HIV-1 primary isolates in vitro, we tested sera and plasma from infected individuals against four clade B primary isolates. These isolates were analyzed further for neutralization by a large panel of human anti-HIV-1 mAbs in order to identify the neutralizing epitopes of these
Monoclonal antibodies to a gp120-derived 419-439 multiple chain peptide recognize a conformational epitope of HIV-1 gp120.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:161 (Poster 56). Unique Identifier : AIDSLINE MED/97927125; Kelker HC; Itri V; Paolino AM; Georgescu R; Valentine FT; New York University Medical Center, New York, NY. Fax: (212) 263-7369.; We studied properties of antibodies elicited in mice by HIV-1 gp120 derived peptide synthesized as a Multiple Chain Peptide 419-439 MCP). This conserved gp120 sequence encompassing amino acid residues 419-439 contains amino acids which are part of the CD4 binding domain. We determined previously that in mice rgp120 do
Antibody reactivity to envelope epitopes correlates with rate of HIV-1 disease progression.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:162 (Poster 57). Unique Identifier : AIDSLINE MED/97927126; Loomis-Price L; Mascola J; Cox J; VanCott T; Mitchell M; Wahren B; Redfield R; Birx D; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-4177.; A variety of antibody-binding and functional studies were carried out on sera from early stage HIV-infected volunteers. Sera prior to vaccination were obtained from healthy (WR 1,2; CD4 greater than 400) HIV-infected volunteers enrolled in a vaccine therapy trial (N=140 total). Of these, 13 rapid progressors (RP) died
Identification of amino acid motifs and biophenotypic properties among primary HIV-1 group M (subtype A-H) and O isolates belonging to neutralization clusters.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:165 (Poster 60). Unique Identifier : AIDSLINE MED/97927129; Nyambi PN; Heyndrickx L; Janssens W; Daeyaert F; Lewi P; Fransen K; Willems B; Coppens S; Vereecken K; Piot P; van der Groen G; New York University Medical Center, New York, NY. Fax: (212) 951-6321.; Objectives: (1) To determine if there exist specific amino acid motifs among HIV-1 isolate neutralization clusters defined by spectral map analysis; (2) To investigate if isolates belonging to the same neutralization cluster share common biophenotypic properties (syncytium and non syncytium inducing ability). Methods:
Expression of subtype C HIV-1 env, and recognition by cytolytic T lymphocytes from a subtype B infected volunteer.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:167 (Poster 62). Unique Identifier : AIDSLINE MED/97927131; Ray SC; Novak NG; Hon H; Lubaki N; Bollinger RC; Johns Hopkins University School of Medicine, Baltimore, MD. Fax: 410); 955-7889.; The env glycoprotein of human immunodeficiency virus type 1 HIV-1) has been the prime target in efforts to develop a vaccine because it is critical for the pathogenesis of the acquired immunodeficiency syndrome. However, this gene is subject to substantial variation, possibly limiting the effectiveness and scope of su
Alteration of neutralization specificity of an HIV-1 V3 antibody by light chain substitution.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:168 (Poster 63). Unique Identifier : AIDSLINE MED/97927132; Reitz MS Jr; Fiorentini S; Davis AE; Veronese F; Watkins BA; Institute of Human Virology, University of Maryland, Baltimore, MD.; Fax: (410) 706-4694.; An IgG1/kappa murine monoclonal antibody (M77) to the V3 region of HIV-1 is able to bind to the gp120 of the IIIB strain of HIV-1, but not to the gp120 of the MN, BA-L or LW strains. Neutralization is similarly type-restricted to the IIIB strain. When the heavy and light chains of M77 are molecularly cloned and expres
CD4 CTL are protected from infection by macrophage-tropic HIV during antigen presentation through the secretion of endogenous, beta-chemokines.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:169 (Poster 64). Unique Identifier : AIDSLINE MED/97927133; Robbins PA; Roderiquez G; Peden KA; Norcross MA; CBER/FDA, Pike, Bethesda, MD. Fax: (301) 480-3256.; CD4 CTL are an important part of the cell mediated immune response to virus. To determine the consequence of HIV infection on CD4 CTL, a CD4 CTL line specific for influenza B virus hemagglutinin peptide 308-320 and HLA-DR 1 were infected with macrophage-tropic and T cell-tropic strains of HIV. Exposure of the CD4 CTL
Development of T-cell clones from HIV-infected individuals using herpesvirus saimiri (HVS) and evidence of relative resistance of CD4+ clones against infection with syncytium-inducing (SI) strains of HIV-1.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:170 (Poster 65). Unique Identifier : AIDSLINE MED/97927134; Saha K; Volsky DJ; Department of Molecular Virology, St. Luke's-Roosevelt Hospital; Center, New York, NY.; HVS, a prototypic gamma-2 herpesvirus endemic to New World squirrel monkeys, has been used in recent years as a powerful tool to immortalize and study human CD4+ and CD8+ T-cell clones. We have used HVS to generate multiple CD4+ and CD8+ T-cell clones from PBL of HIV-1-infected nonprogressors and AIDS patients. By and
Vaccine induced in vitro protective immunity against TCLA and macrophage tropic HIV.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:172 (Poster 67). Unique Identifier : AIDSLINE MED/97927136; Schwartz D; Castillo R; Excler JL; Arango Jaramillo S; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, MD. Fax: (410) 955-0105.; We have previously shown that in vitro resistance to exogenous HIV challenge correlates with in vivo virus suppression among HIV+ individuals. Envelope based experimental HIV vaccines did not confer protective immunity against HIV in vivo, and similarly, none induced long lasting resistance in vitro. Volunteers enroll
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by monoclonal anti-CD4.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:173 (Poster 68). Unique Identifier : AIDSLINE MED/97927137; Shearer MH; Timanus DK; Benton PA; Kennedy RC; Deparment of Microbiology and Immunology, University of Oklahoma; Health Sciences Center, Oklahoma City, OK. Fax: (405) 271-6339.; We have tested a murine monoclonal antibody (MAb) with human CD4 specificity for the ability to neutralize primary human immunodeficiency virus type 1 (HIV-1) isolates from the genetic clades A through E. Human peripheral blood mononuclear cells PBMC) were employed as target cells for these infectivity assays. Various
Evidence for an in vivo role of antibody and complement in clearance and neutralization of HIV-1 plasma virus.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:174 (Poster 69). Unique Identifier : AIDSLINE MED/97927138; Spear GT; Sullivan BL; Department of Immunology/Microbiology, Rush University, Chicago, IL.; Fax: (312) 942-2808.; Determining the in vivo role that antibodies (Ab) play in clearance and neutralization of HIV-1 is important for vaccine development. To test the hypothesis that Ab is bound to a fraction of plasma virus (PV), PV was isolated by ultracentrifugation over sucrose and exposed to normal human serum as a source of compleme
Characterization of memory HIV-specific cytotoxic T lymphocyte CTL) activity in immunologically normal HIV-disease nonprogressors.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:176 (Poster 71). Unique Identifier : AIDSLINE MED/97927140; Tsoukas CM; Bernard NF; Montreal General Hospital, Montreal, Quebec, Canada. Fax: (514); 937-1424.; Six HIV-infected individuals have been identified who differ from most HIV disease progressors by having maintained normal levels of CD4 and CD8 cells (greater than 500 CD4 cells/mm(3)) with CD4:CD8 ratios of greater than 1 since their diagnosis of seropositivity (3 to 11 years). Previous experiments revealed that non
HIV-specific antibodies in external secretions of sero-negative and sero-positive high-risk individuals.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:178 (Poster 73). Unique Identifier : AIDSLINE MED/97927142; Casteel LR; Allen S; Kulhavy R; Zulu I; Omara J; Mestecky J; Departments of Microbiology and Epidemiology, University of Alabama,; Birmingham, AL. Fax: (205) 934-3894.; The purpose of this study was to determine the presence and isotype of HIV-specific antibodies in parotid saliva, serum, milk, and vaginal wash samples of seropositive or seronegative high risk individuals. ELISA and Western blot assays were used for the evaluation of antigen-specific and total levels of Ig in samples
HIV-1 and SIV can induce CD2+ T cells to migrate into intestinal tissues in the primate PBMC-engrafted SCID model.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:179 (Poster 74). Unique Identifier : AIDSLINE MED/97927143; Donze HH; Cummins JE Jr; Schwiebert R; Han Y; Fultz PN; Jackson S; Mestecky J; Department of Microbiology, University of Alabama, Birmingham, AL.; Fax: (205) 934-3894.; In patients infected with HIV-1, increased lymphocytic infiltration occurs in the intestinal tissues. A similar result can be seen as early as one week post-SIV infection of rhesus macaques. To determine if these infections influence the homing patterns of primate PBMC, we infected human and non-human PBMC-engrafted S
Antibody and cytokine profiles in semen from subjects with primary and chronic HIV-1 infections.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:180 (Poster 75). Unique Identifier : AIDSLINE MED/97927144; Edghill-Smith YY; Akridge R; McElrath J; Ashley RL; University of Washington, Seattle, WA. Fax: (206) 527-3885.; HIV-1 transmission via mucosal surfaces of the male urogenital tract is well-documented. However, HIV-specific immune factors in semen have not been fully characterized. We used enhanced chemi-luminescence Western blot (ECL-WB) for IgG, IgG subclasses, and IgA to HIV-1; multinucleated activated galactosidase indicator
Immunohistochemical characterization of dendritic cells and lymphocytes subsets in human genital mucosa.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:181 (Poster 76). Unique Identifier : AIDSLINE MED/97927145; Frankel SS; Klassen M; Hansen C; Listinsky C; Nelson AM; Tavassoli FA; Birx DL; Division of Retrovirology, WRAIR/AFIP, Rockville, MD. Fax: (301); 762-4177.; Epidermal dendritic cells or Langerhans Cells DC/LCs, the most efficient antigen presenting cell in the body, are present within the suprabasal layer of squamous epithelia (0.4% of epidermal cells). Recently, they have been demonstrated to be the target cell in genital transmission of SIV and likely of HIV-1. When vie
Induction of mucosal and systemic responses against HIV-1 gp120 in mice after oral immunization with a single dose of a Salmonella-HIV vector.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:182 (Poster 77). Unique Identifier : AIDSLINE MED/97927146; Hone DM; Pascual DW; Wu S; Lewis GK; Division of Vaccine Research, Institute of Human Virology, Baltimore,; MD. Fax: (410) 706-4694.; Previous studies from our group showed that a Salmonella-HIV vector vaccine that stably expressed recombinant gp120 in the cytoplasm of the vector elicited type 1 T helper cell (T(HI)) responses to HIV-1 gp120. Despite the promise of this HIV vaccine strategy, a major limitation to their use was that multiple immuniza
Induction of potent and sustained systemic antibody responses to soluble oligomeric gp160 of by mucosal immunization.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:184 (Poster 79). Unique Identifier : AIDSLINE MED/97927148; Lewis GK; Tuskan R; Kalyanaraman VS; Hone DM; Division of Vaccine Research, Institute of Human Virology, University; of Maryland, Baltimore, MD. Fax: (410) 706-4694.; Studies from a number of groups suggest that some form of oligomeric gp160/gp120 may be a component of a vaccination strategy against HIV-1. Any such strategy can be simplified if an appropriate mucosal immunization protocol can be found. Accordingly, our group has identified a simple mucosal immunization strategy tha
Collection procedures for human external secretions: a comparative study.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:185 (Poster 80). Unique Identifier : AIDSLINE MED/97927149; Prince SJ; Kulhavy R; Casteel LR; Wright P; Spearman P; Wagner L; Jackson S; Mestecky J; Department of Microbiology, University of Alabama, Birmingham, AL.; Fax: (205) 934-3894.; Appropriate collection of human external secretions is important for evaluation of mucosal humoral immune responses induced by infection or vaccination. In the absence of uniformly accepted collection procedures, we have evaluated various methods for the collection of rectal secretions using analyses of feces, rectal
Mucosal immunization with HIV-1 RT: comparison of immune responses after intranasal and intraperitoneal immunization.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:186 (Poster 81). Unique Identifier : AIDSLINE MED/97927150; Pacheco SE; Ansari-Lari MA; Rogers P; Baylor College of Medicine, Houston, TX. Fax: (713) 770-1260.; An effective vaccine against HIV will require induction of both mucosal and systemic immune responses since the majority of cases of HIV are acquired through mucosal contact eventually leading to systemic spread. Prevalence of either cellular (Type 1) or humoral (Type 2) immune responses has a role in the outcome of v
Identification of two geographically dispersed, complex A/G recombinants of HIV-1 from Djibouti.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:187 (Poster 82). Unique Identifier : AIDSLINE MED/97927151; Carr J; Sanders-Buell E; Salminen M; Birx D; McCutchan F; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-7460.; HIV-1 viruses which are recombinant between different subtypes of HIV-1, such as the clade E virus that spread from Africa to Thailand , can be viruses of great epidemiological importance. Analysis of the entire genome is essential to chart the global spread of new recombinant v
Non-recombinant, near-full length reference clones for HIV-1 subtypes A through H.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:188 (Poster 83). Unique Identifier : AIDSLINE MED/97927152; Gao F; Robertson DL; Morrison SG; Carruthers C; Jian B; Chen Y; Srinivasan A; Girard M; Barre-Sinoussi F; Hahn BH; University of Alabama, Birmingham, AL. Fax: (205) 934-1580.; The classification of HIV-1 into distinct lineages, known as sequence subtypes, within the HIV-1 group M radiation is almost exclusively based on gag and env gene sequences. Except for viruses of subtype B, there are very few full length reference sequences, thus making subtype assignments in regions other than gag an
Patient peripheral blood mononuclear cells frequently contain HIV-1 proviral genomes with interspersed segments of normal and hypermutated DNA.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:189 (Poster 84). Unique Identifier : AIDSLINE MED/97927153; McCutchan F; Vibbard C; Sanders-Buell E; Daniell D; Sheppard HW; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-7460.; Hypermutated sequences are those in which multiple G to A transitions occur in a single replication cycle. Such sequences have been recovered principally from lentivirus infections. Here we investigate the occurrence and structure of hypermutated HIV-1 sequences using patient PBMC obtained within six months of serocon
Full-length genome analysis of an African HIV-1 isolate of subtype F.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:190 (Poster 85). Unique Identifier : AIDSLINE MED/97927154; Gotte D; Carr J; Salminen M; Daniell D; McCutchan F; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-7460.; Multiple genetic subtypes of HIV-1 have been identified, but only some have been evaluated using full-length genome sequences. Here we report a full-length genome sequence of HIV-1 subtype F, permitting, for the first time, an evaluation of inter-subtype relationships in all structural and regulatory genes. The isolat
Genetic characterization of viral quasi-species in blood and cervical secretions of HIV-1 and HIV-2 infected women.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:191 (Poster 86). Unique Identifier : AIDSLINE MED/97927155; Sankale JL; Mboup S; Essex ME; Kanki PJ; Harvard AIDS Institute, Boston, MA. Fax: (617) 432-3575.; We evaluated 25 HIV-2 infected and 11 HIV-1 infected female sex-workers from Dakar, Senegal . The prevalence of viral shedding in genital secretions was 16% and 36.4% for HIV-2 and HIV-1 infected women respectively. We amplified and sequenced multiple clones of the C2-V3-C3 region
Cross clade p17 peptide recognition by antisera to HGP-30, a thirty amino acid synthetic peptide analog from HIV-1 p17.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:192 (Poster 87). Unique Identifier : AIDSLINE MED/97927156; Zimmerman DH; Lloyd JP; Winship D; Sarin PS; CEL-SCI Corporation, Alexandria, VA. Fax: (703) 549-6269.; HGP-30, a thirty amino acid synthetic peptide analog of HIV-1 SF2) p17 (aa86-115) was used to immunize both mice and humans. Since the amino acid sequence of HGP-30 is conserved among different HIV-1 strains and clades, experiments were carried out to determine if antisera obtained by immunizing animals and humans can
Long-term maintenance of HIV-1 infectivity by follicular dendritic cells (FDC).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:192 (Poster 88). Unique Identifier : AIDSLINE MED/97927157; Burton GF; Smith BA; Perelson AS; Liu Y; Gartner S; Stilianakis NI; Szakal AK; Tew JG; Virginia Commonwealth University, Richmond, VA. Fax: (804) 828-9946.; Large amounts of HIV-1 are trapped on the dendritic processes of FDC and remain until the FDC are ultimately destroyed. HIV-1 in plasma has a half-life of 6 hours or less. We sought to determine if HIV-1 trapped in vivo on FDC persisted as infectious particles for longer periods of time. To assess this, HIV-1 was trap
Do HIV-1 seroconverters with a clinical syndrome have a higher plasma virus load than asymptomatic seroconverters?: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:195 (Poster 90). Unique Identifier : AIDSLINE MED/97927159; Cleghorn FR; Jack N; Greenberg M; Edwards J; Weinhold K; O'Brien T; Murphy J; Palace C; Bartholomew C; Blattner W; Institute of Human Virology, University of Maryland, Baltimore, MD.; Fax: (410) 706-1944. E-mail: cleghorn@umbi.umd.edu.; Objective: To determine whether the presence of symptoms at the time of acute seroconversion predicts a higher viral load in early HIV-1 infection. Methods: We ascertained acute seroconverters independent of symptomatology by p24 antigen and HIV-1 antibody screening in a population of STD clinic attenders in
In vitro production of RANTES, MIP-1alpha and MIP-1beta as a correlate of decreased HIV burden.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:196 (Poster 91). Unique Identifier : AIDSLINE MED/97927160; Ferbas J; Plaeger S; Amini S; Hausner MA; Detels R; Giorgi JV; UCLA School of Medicine, Los Angeles, CA. Fax: (310) 794-2195.; In the current study, the ability of cells from HIV-infected persons to secrete RANTES, MIP-1alpha and MIP1beta was examined in culture supernatants harvested after the first 24 hours of antigen stimulation for HIV-specific memory CTL (mCTL) expansion in vitro. We anticipated that donors with mCTL whose cells also pro
A subpopulation of immature blood dendritic cells is highly susceptible to infection by macrophage-tropic HIV-1.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:197 (Poster 92). Unique Identifier : AIDSLINE MED/97927161; Crawford K; Alper C; Shi B; Vasir D; Gabuzda D; Dana-Farber Cancer Institute, Boston, MA. Fax: (617) 632-3113.; Dendritic cells (DC) are unique antigen-presenting cells that are widely distributed in lymphoid and non-lymphoid tissues. Previous studies have suggested that DC play an important role in the transmission of HIV-1 to T cells. However, controversy exists regarding whether DC are directly susceptible to HIV-1 infection
Elevated levels of maternal HIV-1 V3 and neutralizing antibodies are strongly associated with vertical transmission.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:199 (Poster 94). Unique Identifier : AIDSLINE MED/97927163; Hendry RM; Casseb J; Hanson C; Katzenstein D; Zijenah L; Majoma M; Nathoo K; Kasule J; Mbizvo M; Viral and Rickettsial Disease Laboratory, California Department of; Health Services, Berkeley, CA. Fax: (510) 540-3305.; We examined 75 sera collected at delivery from HIV-1 seropositive women in Zimbabwe . Three groups of 25 women were studied; Group 1: infants died in less than 2 years and HIV PCR positive, Group 2: infants seronegative at 2 years, Group 3: infants seropositive at 2 years. Sera we
Selective enhancement of replication of a macrophage-tropic primary HIV-1 isolate by sera from HIV-1 infected individuals.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:200 (Poster 95). Unique Identifier : AIDSLINE MED/97927164; Jolly PE; School of Public Health, University of Alabama, Birmingham, AL. Fax:; (205) 975-3329. E-mail: jollyp@tidwell.soph.uab.edu.; The effect of HIV antisera on the replication of a previously characterized HIV-1 isolate (HIV-1Ba-L) and of a more recently characterized primary macrophage-tropic isolate (92US727) was investigated in primary human macrophages. Sera from HIV-1 infected individuals were heat-inactivated, diluted 10-fold 10(-1) to 10(
HIV-1 subtypes differ in disease progression.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:201 (Poster 96). Unique Identifier : AIDSLINE MED/97927165; Kanki P; Hamel D; Sankale JL; Hsieh CC; Thior I; Essex M; Mboup S; Harvard AIDS Institute, Boston, MA. Fax: (617) 432-3575.; Much of our knowledge of HIV-1 pathogenesis comes from the developed world, where HIV infection is almost exclusively due to subtype B. The recognition of the different HIV-1 subtypes, have led many to question whether properties of HIV-1 infection and its consequences as a whole can be generalized among different sub
HIV pathogenesis in human lymphoid tissue in vitro.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:202 (Poster 97). Unique Identifier : AIDSLINE MED/97927166; Glushakova S; Grivel JC; Baibakov B; Fitzgerald W; Murphy P; Zimmerberg J; Margolis LB; Laboratory of Cellular and Molecular Biophysics, National Institute of; Child Health and Human Development, NIH, Bethesda, MD. Fax: (301); 480-0857.; Critical events in HIV disease occur within the cytoarchitecture of the lymphoid tissue. To follow early events in HIV pathogenesis inside lymphoid tissue, to evaluate the relative contribution of viral and host factors in the course of HIV disease, and to develop a system for tissue testing of anti-virals we develope
Evaluation of a modified version of AMPLICOR HIV-1 monitor test, p24 antigen, and infectious titer with an EM standardized panel of international isolates.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:205 (Poster 100). Unique Identifier : AIDSLINE MED/97927169; Robb ML; Michael N; Mascola J; Birx D; Lane J; Wang J; Dreyer K; McDonough K; Christopherson C; Lu SD; Kwok S; Herman S; Walter Reed Army Institute of Research, Rockville, MD. Fax: (301); 762-4177.; Vaccine and drug intervention studies will require accurate, quantitative measures of HIV-1. The broad genetic diversity of HIV-1 may pose problems for accurate and consistent measurement in some assay formats. In this study, a panel of isolates representing clades A-F were characterized using electron microscopic par
Transmission of a chimeric clade B/F virus from mother to infant in Rio De Janeiro, Brazil.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:206 (Poster 101). Unique Identifier : AIDSLINE MED/97927170; Tanuri A; Lambert J; Nogueira S; Rayfield M; Abreu T; De Goes JT; Janini LM; Pieniazek D; Hugo R; Redfield R; University of Maryland, Institute of Human Virology, Baltimore, MD.; Fax: (410) 706-1992.; The goal of this study was to provide molecular analysis of the HIV-1 strains transmitted from infected mothers to their children in Rio de Janeiro, Brazil , an area endemic for HIV-1 subtypes B,F, and C. These studies are part of the Programa de Assistencia Integral a Gestante HIV
A novel pathogenic "bystander" effect of HIV: induction of apoptosis in resting CD4 T lymphocytes upon homing into lymph nodes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:207 (Poster 102). Unique Identifier : AIDSLINE MED/97927171; Wang L; Gelman B; Konig R; Cloyd M; Departments of Microbiology/Immunology and Pathology, University of; Texas Medical Branch, Galveston, TX. Fax: (409) 772-5065.; Recently, we reported that abortive HIV infection of resting human T lymphocytes upregulated CD62L, a receptor involved in homing to lymph nodes, and induced enhanced homing of these cells from blood to lymph nodes following i.v. injection into SCID mice. HIV-induced homing of resting lymphocytes may be a major mechan
Induction of HIV-1-specific CTL by canarypox vectors in phase I vaccine trials.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:208 (Poster 103). Unique Identifier : AIDSLINE MED/97927172; Carruth LM; Castro MG; Crone SN; Ferris RL; Hall CS; Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, MD. Fax: (410) 955-0964.; Canarypox-based vectors (ALVAC) containing multiple HIV-1 genes are currently being tested as candidate HIV-1 vaccines in AVEG-sponsored trials. Using a highly specific protocol previously developed in our laboratory, we are presently evaluating CTL responses in human volunteers who have been immunized with the ALVAC
Estimates of HIV-1 incidence in a high prevalence heterosexual population suitable for vaccine trials.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:209 (Poster 104). Unique Identifier : AIDSLINE MED/97927173; Cleghorn F; Jack N; Edwards J; Murphy JA; Palace C; Brookmeyer R; Mahabir B; O'Brien T; Bartholomew C; Blattner W; University of Maryland/Institute of Human Virology, Baltimore, MD.; Fax: (410) 706-1944. E-mail: cleghorn@umbi.umd.edu.; Objective: To estimate HIV incidence rates in a population of heterosexual STD clinics targeted for possible vaccine efficacy trials. Methods: A series of epidemiologic studies at this STD clinic provided measured and estimated estimates of HIV-1 incidence. We used the measured incidence, obtained from a prospective c
A population of sexually transmitted disease clinic (STD) attenders in Trinidad suitable for vaccine trials.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:210 (Poster 105). Unique Identifier : AIDSLINE MED/97927174; Edwards J; Jack N; Mahabir B; Murphy J; Palace C; O'Brien T; Blattner W; Bartholomew C; Cleghorn F; University of West Indies/CAREC Medical Research Center, Port of; Spain, Trinidad, W.I. Fax: (809) 625-2327. E-mail: jeffreye@wow.net.; The STD clinic in Port of Spain , Trinidad records 6000-8000 visits per year and is the largest referral center for STD and HIV-1 in the island. During the 24 month period June 1993-July 1995 a tot
Safety and immunogenicity of a live, recombinant canarypox virus expressing gp120TM-MN/gag/protease-LAI and CTL domains of nef and pol-LAI (alvac-HIV vCP300) in HIV-negative volunteers.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:211 (Poster 106). Unique Identifier : AIDSLINE MED/97927175; Finkielsztejn L; Salmon-Ceron D; Excler JL; Zak Dit Zbar O; Raux M; Gomard E; Gluckman JC; Blondeau C; Sicard D; Cochin Hospital French AIDS Agency, Paris, France. Fax:; 33.01.40.46.93.08. E-mail: Laurent.Finkielszteim@cch.ap-hop-paris.; In a phase I trial, 20 healthy, non-HIV-infected volunteers were randomly assigned to receive vCP300 (10(6.2) TCID(50) either at 0, 1, 3, 6, and 12 months (group A) or at 0, 1, 6, and 12 months group B). Sera and mucosal secretions were collected one month after each injection. Antibody (Ab) response was measured by E
Binding antibody against primary HIV-1 isolates induced in recipients of recombinant envelope glycoprotein HIV-1 candidate vaccines (MN/rgp120 and IIIB/rgp120).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:212 (Poster 107). Unique Identifier : AIDSLINE MED/97927176; Gorse GJ; Patel GB; Mandava M; Berman PW; Belshe RB; Saint Louis University Health Sciences Center, St. Louis, MO. Fax:; (314) 771-3816.; Induction of binding antibody to native envelope glycoproteins of primary HIV-1 isolates by MN/- and IIIB/rgp120 vaccines in alum was evaluated. A flow cytometric indirect immunofluorescence assay was used to measure the binding of serum antibodies to PBL s infected with primary HIV-1 isolates. Sera were obtained befo
Condom use determinants among sexually transmitted disease (STD) clinic attendees, Trinidad and Tobago (1993-95).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:213 (Poster 108). Unique Identifier : AIDSLINE MED/97927177; Jack N; Edwards J; Mahabir B; Murphy J; Palace C; O'Brien T; Blattner W; Bartholomew C; Cleghorn F; University of the West Indies/CAREC, Medical Research Center,; Port-of-Spain, Trinidad, W.I. Fax: (809) 625-2327. E-mail:; noreenj@wow.net.; Objectives: An HIV-1 prevalence of 11.0% (1993-95) has been observed among STD clients in Trinidad (estimated overall HIV-1 sero-incidence, 3-5% per annum). Condom usage and skills training has been extensively promoted in this popu
Willingness to participate in HIV clinical trials in sexually transmitted disease (STD) clinic attendees, Trinidad (1993/95).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:214 (Poster 109). Unique Identifier : AIDSLINE MED/97927178; Jack N; Cleghorn F; Edwards J; Mahabir B; Murphy J; Palace C; O'Brien T; Blattner W; Bartholomew C; University of the West Indies, Medical Research Center, Port-of-Spain,; Trinidad, W.I. Fax: (809) 625-2327. E-mail: noreenj@wow.net.; Objectives: Among STD clients in Trinidad , an HIV-1 prevalence of 11.6 % (1993-95) and HIV sero-incidence of 3-5% per annum have been observed. As part of vaccine feasibility studies, the willingness of high risk STD clients to part
Cytokine profiles in human PBMC T cell cultures stimulated with HIV antigens in seronegative volunteers immunized with canarypox expressing HIV antigens and boosted with recombinant SF2 GP120.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:215 (Poster 110). Unique Identifier : AIDSLINE MED/97927179; Sabbaj S; Corey L; Evans T; Keefer M; Excler JL; Duliege AM; Mulligan MJ; McGhee JR; Department of Microbiology and Immunology Vaccine Center, University; of Alabama, Birmingham, AL. Fax: (205) 975-4431.; Studies of T helper (Th) subsets and cytokine profiles in recipients of experimental AIDS vaccines may facilitate the generation of HIV-specific CTL, neutralizing antibodies and mucosal S-IgA antibody responses. To date one of the vaccines with the most promise of generating HIV-specific CTL has been Canarypox express
Immunogenicity of booster injections of recombinant canarypox vectors or peptide in volunteers pre-immunized in HIV-1 phase I trials.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:216 (Poster 111). Unique Identifier : AIDSLINE MED/97927180; Salmon-Ceron D; Pialoux G; Excler JL; Finkielsztejn L; Autran B; Gluckman JC; Moog C; Blondeau C; Sicard D; Cochin Hospital French AIDS Agency, Paris, France. Fax:; 33.01.43.26.88.92. E-mail: Dominique.salmon@cch.ap-hop-paris.Fr.; Subjects previously immunized either with a canarypox virus (CP) expressing gp160 (vCP125, 10(6) TCID(50)), and a recombinant gp160 MN/LAI (group A, n=15), or with a recombinant gp160 MN/LAI, and V3 MN peptide (group B, n=16), were randomly assigned to receive a single injection (both at 10(6) TCID(50)) of vCP125 or a
Safety and immunogenicity of C4V3 polyvalent synthetic peptides in HIV-1 infected HLA B7 positive subjects with CD4 cells greater than 500/mm(3).: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:217 (Poster 112). Unique Identifier : AIDSLINE MED/97927181; Bartlett JA; Wasserman S; Hicks C; Dodge R; Tacket C; Weinhold K; Palker T; Virani-Ketter N; Wittek A; Haynes BF; Duke University Medical Center, Durham, NC. Fax: (919) 681-8474.; C4V3 synthetic peptides are chimeric immunogens comprised of HIV-1 gp120 envelope T helper (Th) determinants, HLA B7 and A2-restricted MHC Class I CTL determinants, and the V3 loop neutralizing antibody determinant. We have used a C4-V3 multivalen immunogen designed to mimic B cell and CTL determinants of four Clade B
Lymphoproliferative responses (LP) to recombinant HIV-1 envelope antigens in neonates & infants receiving gp120 vaccines.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:218 (Poster 113). Unique Identifier : AIDSLINE MED/97927182; Borkowsky W; Wara D; McNamara J; Kang M; Fenton T; McFarland E; Cunningham C; Mofenson L; Duliege A; Francis D; New York University Medical Center, New York, NY. Fax: (212) 263-7806.; Children born to HIV-infected mothers were immunized at birth and at 1,3, & 5 months of age with recombinant gp120 vaccines prepared from either SF-2 [Chiron/Biocine (CB)] or MN [ Genentech G)] strains of HIV-1. Doses of immunogen included 5, 15, & 50 micrograms (CB) or 30, 100, & 300
Cellular adoptive immunotherapy using genetically modified HIV specific CD8+ T cells.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:220 (Poster 115). Unique Identifier : AIDSLINE MED/97927184; Brodie SJ; Patterson BK; Lewinsohn DA; O'Hearn PM; Jiyamapa DK; Muthui D; Diem K; Goddard J; Corey L; Greenberg PD; Riddell SR; Laboratory of Medicine, University of Washington, Seattle, WA. Fax:; (206) 685-3639.; The development of methods to introduce genes into cells has fostered the use of gene marking to evaluate the migration and/or survival of cells after in vivo inoculation and has engendered optimism that gene therapy can be used to correct genetic deficiency diseases. Herein, we examine the safety, migration to lymph
Safety and immunogenicity of HIV recombinant envelope vaccines in HIV-infected infants and children.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:221 (Poster 116). Unique Identifier : AIDSLINE MED/97927185; Lambert JS; VanCott TC; Pragman SL; McNamara J; Katz SL; Fenton T; Kang M; Johnson D; Yogev R; Duliege AM; Francis D; Smith G; University of Maryland, Institute of Human Virology, Baltimore, MD.; Fax: (410) 706-1992.; The objective of this study is to evaluate the safety and immunogenicity of three HIV recombinant glycoproteins in HIV-infected infants and children; HIV-infected infants and children between 1 month and 18 years of age with asymptotic P-1) infection vaccines given are Chiron rgp120 (SF-2) 15 or 50 mcg; MicroGeneSys r
Vaccine-specific antibodies detected in HIV-infected volunteers post immunization with whole, inactivated HIV.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:222 (Poster 117). Unique Identifier : AIDSLINE MED/97927186; Loomis-Price LD; Mitchell M; Moss R; Robb M; Henry M. Jackson Foundation, Rockville, MD. Fax: (301) 762-4177.; Active immunization with whole (gp120-depleted), inactivated, HIV virions is being tested as a potential therapy in HIV positive volunteers. Background: HIV-specific, antibodies complicate characterization of humoral responses specific to vaccination. Linear peptide mapping of antibody responses in immunized patients
Multicenter study of safety and immunogenicity of HIV-1 rgp160 candidate vaccine in seropositive HIV-1 volunteers.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:223 (Poster 118). Unique Identifier : AIDSLINE MED/97927187; Mannhalter JW; Goebel FD; Eibl MM; Belshe RB; Grob P; Erfle V; Griffiths PD; Wahren B; Krohn K; Kunschak M; Engl W; IMMUNO AG, Vienna, Austria. Fax: (.43-1) 20100-550.; A double-blind, placebo (adjuvant)-controlled phase 1/11 therapeutic vaccine study has been performed in 2 groups of HIV-1 seropositive volunteers with CD4 greater than 500/microliters n=96) and with CD4 between 200 and 500/microliter (n=11 2).The volunteers received 6 vaccinations (100 micrograms each) with rgp160 II
A comparison of the effect of immunization with a gp120 depleted inactivated HIV-1 in incomplete Freund's adjuvant (HIV-1 immunogen) compared with immunization with an influenza vaccine on virus specific immune function.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:224 (Poster 119). Unique Identifier : AIDSLINE MED/97927188; Moss RB; Wallace MR; Turner JL; Giermakowska W; Lanza P; Ferre F; Trauger RI; Daigle AE; Richieri SP; Theofan G; Jensen FC; Carlo DJ; Immune Response Corporation, Carlsbad, CA. Fax: (619) 431-8636.; We measured HIV-1 specific lymphocyte proliferation and chemokine production in seropositive individuals receiving the HIV-1 Immunogen (n=15) or Influenza vaccine (n=6). Baseline CD4 counts were similar for subjects receiving either the HIV-1 Immunogen or Influenza vaccine (427 cells/mm3, 436 cells/mm3, respectively).
Survival analyses of proliferative responses to HIV-1 antigens in a gp160 trial.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:225 (Poster 120). Unique Identifier : AIDSLINE MED/97927189; Ratto-Kim S; Sitz KV; Garner RP; Kim JH; Tencer K; Redfield RR; Birx DL; Henry M. Jackson Foundation, Rockville, MD 20850. Fax: (301) 762-4177.; HIV-1-infected individuals (n=141) were randomized to receive either recombinant HIV-1 gp160 or placebo every two months for 5 years as part of a phase II gp160 therapy trial. Baseline proliferative responses to HIV-1 proteins (gp160 and p24) and to a recall antigen (Tetanus Toxoid) were categorized as responders if p
Phase I human trials of thymus nuclear glycoprotein, an immune modulation therapy for the treatment of HIV/AIDS.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:226 (Poster 121). Unique Identifier : AIDSLINE MED/97927190; Zhabilov H; Karageozian V; Karageozian H; Zhabilova J; Keledjian H; Viral Genetics, Inc., South Pasadena, CA. Fax: (818) 441-9753.; Thymus Nuclear Glycoprotein (TNG) is a biologically active linear protein, which is extracted from animal thymus and lymphoid tissues and is chemically purified and modified to enhance its antigenicity. The authors believe TNG works against HIV by two mechanisms of action: (1) by marking HIV infected immune cells so t
"When do I start?"; "what do I start with?"; and "when should I switch?" [editorial]: Aids Patient Care STDS. 1997 Jun;11(3):121-3. Unique Identifier : AIDSLINE MED/97362911; Laurence J
Management of a patient with advanced AIDS and toxic epidermal necrolysis using human growth hormone and G-CSF.: Aids Patient Care STDS. 1997 Jun;11(3):125-9. Unique Identifier : AIDSLINE MED/97362912; Bae RJ; Orgill DP; DeBiasse MA; Demling R; Harvard Medical School, Boston, Massachusetts, USA.; Toxic epidermal necrolysis (TEN) is a serious drug reaction that is occurring with increased frequency among those affected with HIV and AIDS. It carries a grave prognosis for those with advanced AIDS and massive skin involvement. We report a severe case of TEN treated with wound care, intravenous nutrition, human gro
The use of genetic markers to characterize transmission of Pneumocystis carinii.: Aids Patient Care STDS. 1997 Jun;11(3):131-8. Unique Identifier : AIDSLINE MED/97362913; Baughman RP; Keely SP; Dohn MN; Stringer JR; Department of Medicine, University of Cincinnati Medical Center, Ohio,; USA.
Timing of in utero HIV infection: implications for prenatal diagnosis and management of pregnancy.: Aids Patient Care STDS. 1997 Jun;11(3):139-47. Unique Identifier : AIDSLINE MED/97362914; Mandelbrot L; Gynecologic and Obstetric Service, Hospital Cochin-Port Royal, Paris,; France.
Immunizing the HIV-infected child.: Aids Patient Care STDS. 1997 Jun;11(3):149-60. Unique Identifier : AIDSLINE MED/97362915; Rutstein RM; Starr SE; Division of General Pediatrics, Children's Hospital of Philadelphia,; Pennsylvania, USA.
Increased prevalence of renal cell carcinoma in patients with HIV infection.: Aids Patient Care STDS. 1997 Jun;11(3):161-5. Unique Identifier : AIDSLINE MED/97362916; Baynham SA; Katner HP; Cleveland KB; Riverside Memorial Hospital, Newport News, Virginia, USA.; Following the observation of the occurrence of renal cell carcinoma (RCC) in a local HIV patient, a retrospective case review was conducted on our local hospital population to determine if the prevalence of RCC in patients with HIV infection was greater than in the non-HIV population. All 66,715 unique adult patient a
Factors facilitating the sexual transmission of HIV-1.: Aids Patient Care STDS. 1997 Jun;11(3):167-77. Unique Identifier : AIDSLINE MED/97362917; Sullivan AK; Atkins MC; Boag F; Department of HIV/GU Medicine, St. Stephen's Centre, Chelsea and; Westminster Hospital, National Health Service Trust, London, England.
The health care needs of hospitalized patients with AIDS in Taiwan.: Aids Patient Care STDS. 1997 Jun;11(3):179-88. Unique Identifier : AIDSLINE MED/97362918; Wang SS; Lin LC; Kuo BI; Hung-Kuang Institute of Nursing and Medical Technology, Taichung,; Taiwan.; The purpose of this study was to investigate and highlight health care needs as perceived by hospitalized patients with AIDS (PWA) in Taiwan . Convenience sampling was used for this study. Subjects were chosen from one of the medical
Pharmaceuticals for infants and children.: Aids Patient Care STDS. 1997 Jun;11(3):191-2. Unique Identifier : AIDSLINE MED/97362920; Silver J
ACTG 315 drug cocktail restores immune function.: Aids Patient Care STDS. 1997 Jun;11(3):193. Unique Identifier : AIDSLINE MED/97362921
Undetectable HIV levels after triple therapy with indinavir.: Aids Patient Care STDS. 1997 Jun;11(3):193-4. Unique Identifier : AIDSLINE MED/97362922
ACTG 320 trial halted as three-drug arm proves superior.: Aids Patient Care STDS. 1997 Jun;11(3):194. Unique Identifier : AIDSLINE MED/97362923
FDA clearance for ritonavir in children with AIDS.: Aids Patient Care STDS. 1997 Jun;11(3):194. Unique Identifier : AIDSLINE MED/97362924
Possible AZT link to cancer.: Aids Patient Care STDS. 1997 Jun;11(3):195. Unique Identifier : AIDSLINE MED/97362926
Guidelines assist in tolerance of new formulation of Norvir.: Aids Patient Care STDS. 1997 Jun;11(3):196. Unique Identifier : AIDSLINE MED/97362927
Nerve growth factor (NGF) may hold promise in treatment of peripheral neuropathy.: Aids Patient Care STDS. 1997 Jun;11(3):197. Unique Identifier : AIDSLINE MED/97362928
Seldane approval may be withdrawn by FDA.: Aids Patient Care STDS. 1997 Jun;11(3):197-8. Unique Identifier : AIDSLINE MED/97362929
Famciclovir safe and effective for management of shingles.: Aids Patient Care STDS. 1997 Jun;11(3):198. Unique Identifier : AIDSLINE MED/97362931
Orphan drug designation for NTZ expanded.: Aids Patient Care STDS. 1997 Jun;11(3):198. Unique Identifier : AIDSLINE MED/97362930
First oligonucleotide in U.S. clinical trials for CMV retinitis.: Aids Patient Care STDS. 1997 Jun;11(3):198-9. Unique Identifier : AIDSLINE MED/97362932
U.S. Conference of Mayors Report targets HIV prevention and women.: Aids Patient Care STDS. 1997 Jun;11(3):200. Unique Identifier : AIDSLINE MED/97362933; Makulowich GS
Older women still do not protect themselves against HIV infection.: Aids Patient Care STDS. 1997 Jun;11(3):200-1. Unique Identifier : AIDSLINE MED/97362934; Makulowich GS
Institute of Medicine report links 15% of infertility to untreated STDS.: Aids Patient Care STDS. 1997 Jun;11(3):201. Unique Identifier : AIDSLINE MED/97362936; Makulowich GS
HIV insite.: Aids Patient Care STDS. 1997 Jun;11(3):202-3. Unique Identifier : AIDSLINE MED/97362937; Makulowich JS; john@journalist.com
HIV/AIDS case histories: diagnostic problems.: Aids Patient Care STDS. 1997 Jun;11(3):189-90. Unique Identifier : AIDSLINE MED/97362919; Godwin JH; Kripas C; Cornell University Medical College, New York, NY, USA.
Two studies suggest nevirapine benefit for children.: Aids Patient Care STDS. 1997 Jun;11(3):195. Unique Identifier : AIDSLINE MED/97362925
Certain social and cultural factors put women at risk of HIV infection.: Aids Patient Care STDS. 1997 Jun;11(3):201. Unique Identifier : AIDSLINE MED/97362935; Makulowich GS
HIV-1 coreceptors participate in post-entry stages in the virus replication cycle and function in SIV infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:21. Unique Identifier : AIDSLINE MED/97927013; Chackerian B; Long EM; Luciw PA; Overbaugh J; Laboratory of Cellular Oncology, NCI, NIH, Bethesda, MD. Fax: 301); 480-5322.; Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. SIV productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4. In the same macaque cells expressing hu
Early events in primary rectal SIV infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:22. Unique Identifier : AIDSLINE MED/97927014; Butor C; Pretet JL; Couedel-Courteille A; Venet A; Guillet JG; INSERM U445, ICGM, Paris, France. Fax: 33-1-44 07 14 25.; We are investigating rectal transmission in the SIV-macaque model. Enterochromaffin cells (a neuroendocrine cell type of the epithelium) are the first infected cells that we detect. They appear to have been infected by the inoculum. Intraepithelial cells are infected in second, followed by lamina propria cells. Digest
HIV infection of animal models.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:35. Unique Identifier : AIDSLINE MED/97927023; KewalRamani VN; Unutmaz D; Deng HK; Davis CB; Scarborough J; Ellmeier W; Pare G; Littman DR; Skirball Institute, NYU Medical Center, New York, NY. Fax: (212); 263-5711.; Infection of animal models with pathogenic lentiviruses has provided systems to examine primary infection and the development of immunodeficiency and disease seen in human immunodeficiency virus infection. With the identification of cell surface cofactors required for HIV infection, we have developed mice transgenic f
Two cases of transcient HIV infection in adults correlate with genetically resistant lymphocytes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:38. Unique Identifier : AIDSLINE MED/97927024; Cloyd MW; Ramsey KM; Depts of Micro./Immun. and Path., University of Texas Medical Branch,; Galveston, TX. Fax: (409) 772-5065.; In a survey of seventeen Western blot-negative, EIA-negative individuals at high risk for HIV infection, we previously showed that 4 were infected by isolation of HIV from cultures of their PHA-stimulated PBLs and by demonstrating that they possessed anti-HIV envelope antibodies detected by non-denaturing live-cell im
Antibodies to CCR-5 receptors, and beta chemokines, generated by xenogeneic immunization, in the prevention of SIV infection in macaques.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:39. Unique Identifier : AIDSLINE MED/97927025; Lehner T; Wang Y; Bravery CA; Doyle C; Mitchell E; Bogers W; Raport C; Schweickart V; Wood C; Gray P; Bergmeier LA; Tao L; Kelly CG; Heeney JL; Department of Immunology, UMDS at Guy's Hospitals, London, England.; Fax: 44 171 407 6693.; Complete protection against live pathogenic simian immunodeficiency virus (SIV) infection in macaques has been consistently achieved by immunization with inactivated SIV grown in human T cells. Here we demonstrate that xenogeneic immunization of macaques with SIV grown in human CD4+ T cells induces serum antibodies to
HIV-1 DNA vaccination of pregnant chimpanzees induces cellular and humoral immune responses including placental transfer of antibodies and specific IgA antibodies in breast milk.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:48. Unique Identifier : AIDSLINE MED/97927032; Bagarazzi ML; Boyer JD; Dang K; Chattergoon M; Javadian MA; Wang B; Weiner DB; University of Pennsylvania, Philadelphia, PA. Fax: (215) 573-9436.; We have reported on the use of DNA immunization for the production of immune responses in vivo. Both humoral and cellular immune responses develop following in vivo inoculation of HIV-1 antigen expression cassettes. In chimpanzees, protection from high dose heterologous challenge has been achieved by DNA vaccine casse
Beta-chemokines and their receptors in human reproductive tract secretions and tissues.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:52. Unique Identifier : AIDSLINE MED/97927036; Anderson DJ; Fichorova R; Wang YM; Pudney J; Department of Obstetrics/Gynecology, Brigham and Women's Hospital,; Boston, MA. Fax: (617) 432-0359.; The beta-chemokines RANTES, MIP-1alpha and MIP-1beta inhibit infection by macrophage-tropic primary isolates of HIV-1 in vitro, and their common receptor, CCR-5, was recently identified as a principal cofactor for entry of primary HIV-1 isolates into target cells in vitro. Two other chemokine receptors, CCR3 and fusin
Protection against heterologous, primary HIV isolate infection of chimpanzees with an adenovirus-gp120 combination vaccine regimen.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:91. Unique Identifier : AIDSLINE MED/97927064; Robert-Guroff M; Markham PD; Romano J; Patterson J; Kaur H; Richardson E; Aldrich K; Conley A; Sinangil F; Eldridge J; Udem S; NCI, Basic Research Laboratory, Bethesda, MD. Fax: (301) 496-8394.; Priming with adenovirus-HIV-1(MN) env recombinants and boosting with HIV-1(SF2) gp120 has protected 4 of 4 immunized chimpanzees against homologous low-dose HIV-1(SF2) challenge. A year later without further immunization, 3 of these 4 (1P, 2P(A), 3P) were protected from infection by high-dose HIV-1(SF2). In further st
Use of mouse to model HIV disease: lack of CD4 cell depletion in SCID-hu mice infected by a rev-independent HIV-1.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:97. Unique Identifier : AIDSLINE MED/97927068; Felber B; Valentin A; Rosati M; Aldrovandi G; Zack J; von Gegerfelt A; Zolotukhin A; Pavlakis GN; ABL-Basic Research Program, National Cancer Institute-FCR&DC,; Frederick, MD. Fax: (301) 846-6368, or (301) 846-7146.; We studied the effects of Rev/RRE replacement by the heterologous RNA posttranscriptional control element CTE on HIV-1 replication using SCID-hu mice. Two infectious HIV-1 molecular clones were studied, containing intact or deleted nef genes in addition to the Rev/RRE replacement. The nef+ and nef- Rev-independent vir
HIV-1 coreceptors as determinants of pathogenesis: progress towards transgenic animal models.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:99. Unique Identifier : AIDSLINE MED/97927070; Goldsmith MA; Speck R; Atchison RE; Chesebro B; Esser U; Taylor J; Charo IF; Kindt TJ; J. David Gladstone Institutes, San Francisco, CA. Fax: (415) 826-1514.; The discovery of human chemokine receptors as critical cofactors for cellular entry by the human immunodeficiency virus (HIV) represents an important paradigm shift. Extensive information has emerged regarding structure/function relationships governing the interactions between HIV envelope glycoproteins and these core
Safety and immunogenicity of a multi-envelope, vaccinia virus-based HIV-1 vaccine in chimpanzees.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:116 (Poster 11). Unique Identifier : AIDSLINE MED/97927081; Hurwitz JL; Rencher SD; Lockey TD; Rodgers Q; Owens RJ; McClure HM; Compans RW; Montefiori DC; St. Jude Children's Research Hospital, Memphis, TN. Fax: (901); 495-3107.; Envelope (Env) proteins are the sole virally-encoded external proteins of HIV-1 and targets of neutralizing antibody activity. Unfortunately, Env sequences are not conserved among HIV-1 isolates and antibodies elicited toward one virus type will not necessarily neutralize another. For this reason, we have prepared a m
HIV-1 DNA vaccination of pregnant chimpanzees induces cellular and humoral immune responses including placental transfer of antibodies and specific IgA antibodies in breast milk.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:133 (Poster 28). Unique Identifier : AIDSLINE MED/97927097; Bagarazzi ML; Boyer JD; Dang K; Chattergoon M; Ali Javadian M; Wang B; Weiner DB; University of Pennsylvania, Philadelphia, PA. Fax: (215) 573-9436.; We have reported on the use of DNA immunization for the production of immune responses in vivo. Both humoral and cellular immune responses develop following in vivo inoculation of HIV-1 antigen expression cassettes. In chimpanzees, protection from high dose heterologous challenge has been achieved by DNA vaccine casse
Early events in primary rectal SIV infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:135 (Poster 30). Unique Identifier : AIDSLINE MED/97927099; Butor C; Pretet JL; Couedel-Courteille A; Venet A; Guillet JG; INSERM, ICGM, Paris, France. Fax: 33-1-44 07 14 25.; We are investigating rectal transmission in the SIV-macaque model. Enterochromaffin cells (a neuroendocrine cell type of the epithelium) are the first infected cells that we detect. They appear to have been infected by the inoculum. Intraepithelial cells are infected in second, followed by lamina propria cells. Digest
HIV co-receptor analysis in human and non-human primate PBMCs.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:155 (Poster 50). Unique Identifier : AIDSLINE MED/97927119; Benton PA; Timanus DK; Shearer MH; Lee DR; Kennedy RC; University of Oklahoma Health Sciences Center, Oklahoma City, OK. Fax:; (405) 271-6339.; Certain individuals who carry a particular 32 base pair (bp) deletion in the recently identified HIV-1 co-receptor, CCR5, may be less susceptible to HIV-1 infection in vivo. However, several in vitro studies indicate that the correlation between co-receptor usage, HIV-1 subtype, tropism, and susceptibility to infectio
Beta-chemokine dependent and independent effect of CD8+ T cell mediated inhibition of HIV replication in CD4+ T cells and macrophages.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:163 (Poster 58). Unique Identifier : AIDSLINE MED/97927127; Murthy KK; Cobb EK; Payne JS; Southwest Foundation for Biomedical Research, San Antonio, TX. Fax:; (210) 670-3330.; Beta-Chemokines (RANTES, MIP-1alpha, MIP-1beta) have been shown to inhibit replication of macrophage (M0) tropic isolates of HIV in CD4+ cells, but have little, or no, effect on the replication of T cell tropic isolates. In contrast, beta-chemokines used individually, or in combination, fail to inhibit replication of
Co-receptor utilization as a determinant of differential neutralization sensitivity of primary and T cell line-adapted isolates of HIV.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:164 (Poster 59). Unique Identifier : AIDSLINE MED/97927128; Nunberg JH; Follis KE; Moudgil T; LaCasse RA; University of Montana, Montana Biotechnology Center, Missoula, MT.; Fax: (406) 243-6425.; Primary isolates (PIs) of HIV differ from laboratory-adapted isolates in a number of biological phenotypes. Among these, we have shown Pl viruses to be resistant to virus neutralization VN) by rgp120 vaccine antisera, by soluble CD4, and by certain monoclonal antibodies-all of which potently inhibit in vitro infection
Characterization of HIV-1 suppressor activity mediated by human and chimpanzee CD8+ T lymphocytes.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:166 (Poster 61). Unique Identifier : AIDSLINE MED/97927130; Pal R; Brown M; Nair BC; Markham PD; DeVico A; Advanced BioScience Laboratories, Inc., Kensington, MD. Fax: 301); 468-9466.; Secretion of soluble HIV suppressor factors by CD8+ T cells in response to viral antigens may provide a correlate of protection in vaccine trials. The evaluation of this possibility requires continued efforts to identify these factors and the isolates they target. To examine this, CD8+ T lymphocytes from HIV-1-infecte
CD8+ T-cell mediated in vitro resistance to HIV is not dependent on CC chemokines.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:171 (Poster 66). Unique Identifier : AIDSLINE MED/97927135; Schwartz D; Castillo R; Sharma U; Feng Sung HF; Arango-Jaramillo S; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, MD. Fax: (410) 955-0102.; CC chemokine levels and allelic variation in CC chemokine receptors have been proposed as resistance factors for HIV+ asymptomatic and exposed uninfected individuals. Among HIV+ individuals the phenotype of in vitro resistance to HIV correlates with low plasma viremia and is therefore predictive of outcome. We have st
A sensitive microtiter infectivity assay for macrophage-tropic and primary isolates of HIV-1 based on the transactivation of a stably integrated gene for the green fluorescent protein.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:175 (Poster 70). Unique Identifier : AIDSLINE MED/97927139; Tan GT; Honnen WJ; Kayman SC; Pinter A; Laboratory of Retroviral Biology, Public Health Research Institute,; New York, NY. Fax: (212) 578-0804.; Reporter cell lines for the quantitative assay of HIV infectivity were developed using HOS cells rendered susceptible to HIV infection by transfection of genes for CD4, and either CCR5 or CXCR4 as the respective coreceptor for macrophage-tropic and T cell tropic HIV isolates. This 96-well microtiter assay is based on
Beta-chemokines and their receptors in human reproductive tract secretions and tissues.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:177 (Poster 72). Unique Identifier : AIDSLINE MED/97927141; Anderson DJ; Fichorova R; Wang YM; Pudney J; Department of Obstetrics/Gyncology, Brigham and Women's Hospital,; Boston, MA. Fax: (617) 432-0359.; The beta-chemokines RANTES, MIP-1alpha and MIP-1beta inhibit infection by macrophage-tropic primary isolates of HIV-1 in vitro, and their common receptor, CCR-5, was recently identified as a principal cofactor for entry of primary HIV-1 isolates into target cells in vitro. Two other chemokine receptors, CCR3 and fusin
Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:183 (Poster 78). Unique Identifier : AIDSLINE MED/97927147; June CH; Riley JL; Levine BL; Feng Y; Kaushal S; Ritchey DW; Bernstein W; Weislow OS; Berger EA; St. Louis DC; Carroll RG; Division of Retrovirology, Walter Reed Army Institute of Research,; Bethesda, MD. Fax: (301) 295-6484.; A potent anti-viral effect was found to be mediated by certain forms of CD28 signal transduction. CD28 receptor costimulation can lead to polyclonal expansion of CD4+ cells from HIV-infected donors during cell culture. Moreover, CD28 stimulation rendered CD4+ cells from uninfected donors highly resistant to HIV-1 infe
HIV-1 coreceptors participate in post-entry stages in the virus replication cycle and function in SIV infection.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:194 (Poster 89). Unique Identifier : AIDSLINE MED/97927158; Chackerian B; Long EM; Luciw PA; Overbaugh J; Laboratory of Cellular Oncology, NCI, NIH, Bethesda, MD. Fax: 301); 480-5322.; Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. SIV productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4. In the same macaque cells expressing hu
Expression of CCR-5 but not CXCR-4 on freshly isolated human Langerhans cells correlates with sexual transmission of macrophage-tropic HIV-1 strains.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:198 (Poster 93). Unique Identifier : AIDSLINE MED/97927162; Golding H; Blauvelt A; Lapham CK; Zaitseva M; Division of Viral Products, CBER, FDA, Bethesda, MD. Fax: (301); 496-1810.; Sexual transmission of HIV-1 has been shown to be restricted to macrophage (M)-tropic strains. Langerhans cells (LC) in mucosal epithelium were proposed to be the first cell type infected during initial exposure to HIV. In this study, anti-CXCR-4 and anti-CCR-5 polyclonal rabbit IgGs were used in a sensitive flow cyto
CCR-5 gene defects and viral phenotype are associated with nonprogressive HIV-1 disease.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:203 (Poster 98). Unique Identifier : AIDSLINE MED/97927167; Michael NL; Chang G; Louie LG; Mascola JR; Dondero D; Birx DL; Sheppard HW; Walter Reed Army Institute of Research, Rockville, MD. Fax: (301); 762-4177.; Cellular entry of human immunodeficiency virus type 1 (HIV-1) requires binding to both CD4 and to one of the chemokine receptors recently discovered to act as co-receptors. Viruses that infect T-cell lines form syncytia (syncytium-inducing, SI), are frequently found in late-stage HIV disease, and utilize the chemokine
Quantification and localization of CCR5 mRNA expression in the female genital tract.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:204 (Poster 99). Unique Identifier : AIDSLINE MED/97927168; Patterson BK; Jiyamapa D; Brown C; Garcia P; Northwestern University Medical School, Chicago, IL. Fax: (312); 908-0367.; Sexual transmission is the leading cause of HIV-1 infection. Non syncytium inducing (NSI), macrophage tropic isolates are postulated to be the predominant sexually transmitted variant although exceptions exist. Recent studies implicate the chemokine receptor CCR5 as the predominant macrophage tropic HIV coreceptor, wh
Facilitated nucleic acid vaccination of humans with an HIV-1 expressing DNA boosts immune responses against the envelope glycoprotein.: Conf Adv AIDS Vaccine Dev. 1997 May 4-7;:219 (Poster 114). Unique Identifier : AIDSLINE MED/97927183; Boyer JD; Ugen KE; Chattergoon M; MacGregor RR; Bagarazzi M; Higgins T; Coney L; Ciccarelli R; Ginsberg R; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia, PA. Fax: (215); 573-9436.; The development of an effective vaccine against HIV-1 is crucial for the control of the global epidemic of this human retrovirus. Recently, we and others have explored the potential of direct DNA plasmid inoculation as a vaccination regimen for HIV-1. We have now shown the utility of DNA inoculation to be used as a pr
Is there a wastage of resources due to non-specificity of anti-HIV ELISAs?: Transfus Med. 1991 Dec;1(4):269-71. Unique Identifier : AIDSLINE MED/97406399; Rodriguez MA; Runganga J; Contreras M; Ahya R; Barbara JA; North London Blood Transfusion Centre, Colindale, London, U.K.; A library of anti-HIV ELISA grey-area and repeatably reactive samples sent for confirmatory testing, were retested using a second technique, the modified (Fujirebio Gelatin Particle) agglutination test (MAT). On testing 224 grey-area reactive samples, only four were found to be reactive with this second test. On ret
Transfusion in crisis: HIV in the developing world.: Transfus Med. 1991 Mar;1(1):1-3. Unique Identifier : AIDSLINE MED/97406358; Mortimer PP; Public Health Laboratory Service, London.
Oliver Memorial Lecture 1989. The evolution and future of haemophilia therapy.: Transfus Med. 1991 Mar;1(1):5-12. Unique Identifier : AIDSLINE MED/97406359; Bloom AL; Department of Haematology, University of Wales College of Medicine,; Cardiff, UK.; Lane (1840) first noted the beneficial effect of blood transfusion in controlling haemophilic bleeding following ophthalmic surgery. The appreciation that haemophilia is due to a plasma defect, at first thought to be prothrombin, coincided with the discovery of blood groups. This led in due course to the discovery of
Antibody to hepatitis C virus in blood donors found positive for other agents. II. Anti-HIV-1.: Transfus Med. 1991 Sep;1(3):195-7. Unique Identifier : AIDSLINE MED/97406388; Moore MC; Barbara JA; Hewitt PE; North London Blood Transfusion Centre, London, U.K.; Stored serum samples from 24 blood donors confirmed positive for anti-HIV-1 were tested for antibody to hepatitis C virus (HCV). Those repeatedly reactive using the anti-HCV ELISA screening test were retested by the HCV recombinant immunoblot (RIBA). Risk-factors for the contraction of HIV infection that had been elic
Overview: diagnostic tests for viral infections transmitted by blood.: Nucl Med Biol. 1994 Apr;21(3):407-17. Unique Identifier : AIDSLINE MED/97378703; Holland PV; Sacramento Medical Foundation Blood Center, California, USA.; The risk of transmitting viral infections by transfusion today is quite remote. The many, sensitive, diagnostic tests in place, when applied to the blood of volunteer, unpaid (unremunerated), unpressured donors who are also carefully evaluated at the time of donation, make blood and blood component transfusions very s
[Limits of immunoserologic and molecular diagnosis of hepatitis C]: Nucl Med Biol. 1994 Apr;21(3):419-31. Unique Identifier : AIDSLINE MED/97378704; Trepo C; Alonso C; Li JS; Qu D; Laurent F; Vitvitski L; Service d'Hepato-Gastroenterologie, Hotel-Dieu, Lyon, France.; Hepatitis C is the most common cause of post-transfusion hepatitis, as well as of the viral chronic liver disease in the western world. However since it is even more often asymptomatic than HBV, this is not truly recognized. The detection of hepatitis C can only rely on serological and virological methods and require
Serological diagnosis of HTLV-I/II infections in France.: Nucl Med Biol. 1994 Apr;21(3):433-9. Unique Identifier : AIDSLINE MED/97378705; Lemaire JM; Voisin S; Coste J; Centre Regional de Transfusion Sanguine, Montpellier, France.; During the last years, important improvements have been made in the field of HTLV-I/II serodiagnosis. The screening tests, which combine higher performances of the sensitivity towards HTLV-I and HTLV-II samples, and better specificity, are manifold. The criteria of positivity by western-blots have been reinforced. As
Use of the HIV-1 protease for excision of growth-hormone-releasing factor from synthetic and recombinant peptide precursors.: Biotechnol Appl Biochem. 1997 Aug;26 ( Pt 1):39-49. Unique Identifier : AIDSLINE MED/97405332; Tomasselli AG; Mildner AA; Paddock DJ; Wheeler JS; Kubiak TM; Martin RA; Moseley WM; Mott JE; White MC; Leone JW; Heinrikson RL; Biochemistry, Pharmacia & Upjohn, Kalamazoo, MI 49007, USA.; An autolysis-resistant mutant of the HIV-I protease was employed for removal of metabolically stabilized and highly bioactive analogues of bovine growth-hormone-releasing factor (bGRF) from their larger either synthetic or recombinant precursors. The N-terminal four amino acids in two selected model GRF analogues, Y1I
Pathologic quiz case 1. Pneumocystic lymphadenitis.: Arch Otolaryngol Head Neck Surg. 1997 Aug;123(8):880, 882-3. Unique Identifier : AIDSLINE MED/97407314; Reisacher WR; Pincus RL
Identification and treatment of cytomegalovirus retinitis in patients with AIDS.: J Am Acad Nurse Pract. 1997 Jul;9(7):329-31. Unique Identifier : AIDSLINE MED/97419749; Speyrer MP
Expression of CD8beta and alteration of cell surface phenotype in adult T-cell leukaemia cells.: Br J Haematol. 1997 Jul;98(1):151-6. Unique Identifier : AIDSLINE MED/97376808; Joh T; Yamada Y; Seto M; Kamihira S; Tomonaga M; Laboratory of Chemotherapy, Aichi Cancer Centre Research Institute,; Japan.; Typical adult T-cell leukaemia (ATL) cells have a CD4+ CD8- cell surface phenotype, but atypical phenotypes such as CD4+ CD8+ and CD4- CD8+ have also been reported. The CD8 molecule is composed of alpha and beta chains and commonly used monoclonal antibodies against CD8 molecule detect only CD8alpha. Since it has been
Diagnosis of HIV-related primary central nervous system lymphoma: is there still a role for brain biopsy? A case history.: Ann Oncol. 1997 May;8(5):491-6. Unique Identifier : AIDSLINE MED/97377930; Viale P; Pagani L; Mori M; Sacchini D; Cerri L; Carella E; Rocca A; Alberici F; Division of Infectious Diseases, Piacenza General Hospital, Italy.
Metabolites of the antipsychotic agent clozapine inhibit the replication of human immunodeficiency virus type 1.: Schizophr Res. 1997 May 3;25(1):63-70. Unique Identifier : AIDSLINE MED/97320044; Jones-Brando LV; Buthod JL; Holland LE; Yolken RH; Torrey EF; Stanley Laboratory for the Study of Schizophrenia and Bipolar Disease,; Department of Pediatrics, Johns Hopkins University, Baltimore, MD; 21205, USA.; Schizophrenia is a serious and often debilitating neuropsychiatric disease of worldwide importance. Current therapy relies on the use of typical antipsychotic medications, which specifically inhibit binding of ligand at the D2 dopamine receptor, and atypical medications which display little activity for this receptor
HIV-1 genome dimerization: kissing-loop hairpin dictates whether nucleotides downstream of the 5' splice junction contribute to loose and tight dimerization of human immunodeficiency virus RNA.: Biochemistry. 1997 Aug 5;36(31):9501-8. Unique Identifier : AIDSLINE MED/97383156; Laughrea M; Jette L; McGill AIDS Centre, Lady Davis Institute for Medical Research, Sir; Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.; The genome of all retroviruses consists of two identical RNAs noncovalently linked near their 5 end. Adjacent genomic RNAs from human immunodeficiency virus type 1 (HIV-1) can form loose or tight dimers depending on whether their respective kissing-loop hairpins (nts 248-270 in HIV-1Lai) bond via their autocomplement
Gender and social differences in adolescent sexuality and reproduction in Nicaragua.: J Adolesc Health. 1997 Jul;21(1):39-46. Unique Identifier : AIDSLINE MED/97358390; Zelaya E; Marin FM; Garcia J; Berglund S; Liljestrand J; Persson LA; Department of Preventive Medicine, UNAN, Leon, Nicaragua.; PURPOSE: The aim of this research was to study gender and social differences in adolescent sexuality and reproduction, as reflected in age at first intercourse and age at first pregnancy, as a basis for future interventions in the municipality of Leon, Nicaragua . METHODS: In a c
[Practical considerations in the treatment of patients with AIDS and tuberculosis (letter; comment)]: Aten Primaria. 1996 Nov 30;18(9):527-8. Unique Identifier : AIDSLINE MED/97290910; Sanchez Munoz LA; Perez Boillos MJ; Miguel de la Villa F
Mycobacterium tuberculosis enhances iNOS mRNA expression and HIV replication in human astrocytoma cells.: Neuroreport. 1997 May 27;8(8):1897-901. Unique Identifier : AIDSLINE MED/97366263; Persichini T; Mancino G; Cappelli G; Colizzi V; Lauro GM; Department of Biology, University of Roma Tre, Italy.; The aim of this study was to investigate whether Mycobacterium tuberculosis (MTB) infection affects human immunodeficiency virus HIV) replication in T67 human astrocytoma cells and whether HIV and MTB infections induce iNOS mRNA expression in T67 cells. T67 cells were susceptible to both HIVLai and MTB infections, and
HIV transmitted by bone graft [news]: Br J Theatre Nurs. 1997 Jul;7(4):45. Unique Identifier : AIDSLINE MED/97417955
HIV and AIDS: time to live.: Reflections. 1997 1st Quarter;23(1):17. Unique Identifier : AIDSLINE MED/97421679; Holzemer WL; University of California, San Francisco School of Nursing Department; of Community Health Systems, USA.
Preventing perinatal infections [editorial; comment]: BMJ. 1997 Jul 26;315(7102):199-200. Unique Identifier : AIDSLINE MED/97397195; Hofmeyr GJ; McIntyre J
Informed consent. Study in which patients had HIV tests could have been designed differently [letter; comment]: BMJ. 1997 Jul 26;315(7102):251-2. Unique Identifier : AIDSLINE MED/97397229; Malin A; Lockwood D
Informed consent. Informed consent is light years away for black African patients [letter; comment]: BMJ. 1997 Jul 26;315(7102):252. Unique Identifier : AIDSLINE MED/97397230; Mhlongo SW; Mdingi GV
Systematic review of role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus.: BMJ. 1997 Aug 9;315(7104):333-7. Unique Identifier : AIDSLINE MED/97416503; Dore GJ; Kaldor JM; McCaughan GW; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, Sydney, Australia.; OBJECTIVE: To assess the role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus. DESIGN: Published studies of hepatitis C transmission were examined. Twenty nine studies with identified sources of hepatitis C infection who were tested for presence of hepatitis C RNA b
Solvation effects are responsible for the reduced inhibitor affinity of some HIV-1 PR mutants.: Protein Sci. 1997 May;6(5):1024-30. Unique Identifier : AIDSLINE MED/97289988; Sussman F; Villaverde MC; Davis A; Oklahoma University, Health Sciences Center, Oklahoma City 73104, USA.; fredy@rev.uokhsc.edu; The formulation of HIV-1 PR inhibitors as anti-viral drugs has been hindered by the appearance of protease strains that present drug resistance to these compounds. The mechanism by which the HIV-1 PR mutants lower their affinity for the inhibitor is not yet fully understood. We have applied a modified Poisson-Boltzman
[AIDS: a world, a desire]: Infirm Que. 1997 May-Jun;4(5):15-6. Unique Identifier : AIDSLINE MED/97419696; Albert M
[Profile: Antoinette Gimenes-Lambert--15 years of fight against AIDS (interview by Sylvie Valliere)]: Infirm Que. 1997 May-Jun;4(5):26-7. Unique Identifier : AIDSLINE MED/97419698; Gimenez-Lambert A
Neuropathogenesis of chimeric simian/human immunodeficiency virus infection in pig-tailed and rhesus macaques.: Brain Pathol. 1997 Jul;7(3):851-61. Unique Identifier : AIDSLINE MED/97361007; Raghavan R; Stephens EB; Joag SV; Adany I; Pinson DM; Li Z; Jia F; Sahni M; Wang C; Leung K; Foresman L; Narayan O; Marion Merrell Dow Laboratory of Viral Pathogenesis, University of; Kansas Medical Center, Kansas City, USA. rraghava@kumc.edu; We recently reported that a chimeric simian/human immunodeficiency virus (SHIVKU-1) developed in our laboratory caused progressive depletion of CD4+ T lymphocytes and AIDS within 6 months of inoculation into pig-tailed macaques (M. nemestrina). None of the pig-tailed macaques showed productive SHIV infection in the ce
Meta-analysis of prophylactic treatments against Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):104-14. Unique Identifier : AIDSLINE MED/97383117; Bucher HC; Griffith L; Guyatt GH; Opravil M; Department of Clinical Epidemiology and Biostatistics, McMaster; University, Hamilton, Canada.; In a meta-analysis, we examined the efficacy of aerosolized pentamidine, trimethoprim-sulfamethoxazole, and dapsone or dapsone/pyrimethamine for the prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in patients with HIV infection. Of 22 trials, 13 compared trimethoprim-sulfamethoxazole with aero
Determinants of complementary therapy use in HIV-infected individuals receiving antiretroviral or anti-opportunistic agents.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):115-20. Unique Identifier : AIDSLINE MED/97383118; Ostrow MJ; Cornelisse PG; Heath KV; Craib KJ; Schechter MT; O'Shaughnessy M; Montaner JS; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To identify sociodemographic and clinical characteristics of persons using complementary therapy in an HIV/AIDS drug treatment program and to evaluate the associations between complementary therapy use and participant characteristics. METHODS: A cross-sectional study using program participants who completed
HIV-1 RNA detection in plasma for the diagnosis of infection in neonates. The French Pediatric HIV Infection Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):121-5. Unique Identifier : AIDSLINE MED/97383119; Delamare C; Burgard M; Mayaux MJ; Blanche S; Doussin A; Ivanoff S; Chaix ML; Khan C; Rouzioux C; Laboratoire de Virologie, Hopital Necker, Paris, France.; The objective of this study was to assess the frequency of detection of HIV-1 RNA in plasma of neonates born to HIV-1-seropositive mothers and to determine the diagnostic value of this method in the neonatal period. The study involved 96 infants among those enrolled in the French National Prospective Study. HIV-1 RNA
Compliance with voluntary prenatal HIV testing in a large health maintenance organization (HMO).: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):126-30. Unique Identifier : AIDSLINE MED/97383120; Limata C; Schoen EJ; Cohen D; Black SB; Quesenberry CP Jr; Department of Genetics, Kaiser Permanente Medical Care Program,; Oakland, California 94611, USA.; Results of a recent national clinical trial show that maternal-to-fetal transfer of HIV can be decreased threefold by prenatal, intrapartum, and neonatal treatment. The question is whether to make prenatal HIV testing compulsory or to encourage voluntary testing. Kaiser Permanente Northern California (KPNC), which has
Penetration of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of zidovudine, into the cerebrospinal fluid of HIV-1-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):131-6. Unique Identifier : AIDSLINE MED/97383121; Hoetelmans RM; Kraaijeveld CL; Meenhorst PL; Mulder JW; Burger DM; Koks CH; Beijnen JH; Department of Pharmacy, Slotervaart Hospital, Amsterdam, The; Netherlands.; The penetration of 3 -amino-3 -deoxythymidine (AMT) into the cerebrospinal fluid (CSF) of HIV-1-infected patients has been investigated. In 23 patients who used zidovudine (ZDV) chronically, CSF and plasma samples were assayed for AMT and ZDV. The influences of time between ZDV oral administration and lumbar puncture,
Growth hormone secretion in HIV-positive versus HIV-negative hemophilic males with abnormal growth and pubertal development. The Hemophilia Growth and Development Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):137-44. Unique Identifier : AIDSLINE MED/97383122; Ratner Kaufman F; Gertner JM; Sleeper LA; Donfield SM; Department of Pediatrics, USC School of Medicine, Childrens Hospital; Los Angeles, California 90027, USA.; Growth and pubertal development in hemophilic males, age 6-19 years at baseline, were evaluated over a 3.5-year period in 207 HIV-positive and 126 HIV-negative subjects as part of the Hemophilia Growth and Development Study. METHODS: Thyroid function, insulin-like growth factor I (IGF-1) levels, bone age, cranial magn
Comparative rates of disease progression among persons infected with the same or different HIV-1 strains. The Transfusion Safety Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):145-50. Unique Identifier : AIDSLINE MED/97383123; Operskalski EA; Busch MP; Mosley JW; Stram DO; Department of Medicine, University of Southern California School of; Medicine, Los Angeles 90032, USA.; Rates of HIV-1 progression vary widely. To investigate the relative effects of viral and host characteristics on course, we compared persons infected by the same and different subtype B strains. Forty-three infection chain clusters were identified, each defined by an infected blood donor, that donor s recipients, and
Trends in HIV counseling and testing of clients attending a public sexually transmitted disease clinic in Portland, Oregon, 1989-1995.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):151-6. Unique Identifier : AIDSLINE MED/97383124; Ni H; Hedberg K; Torok J; Dubickas SH; Fleming D; Center for Disease Prevention and Epidemiology, Oregon Health; Division, Department of Human Resources, Portland 97232, USA.; To assess the trend in acceptance of human immunodeficiency virus counseling and testing (HIV-CT) among clients attending a public sexually transmitted disease (STD) clinic, 13,139 clients who visited the largest STD clinic in Oregon at least once from 1989 through 1995 were investigated. Overall, 6236 (47.5%) of the
Who uses needle exchange? A study of injection drug users in treatment in San Francisco, 1989-1990.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):157-64. Unique Identifier : AIDSLINE MED/97383125; Hahn JA; Vranizan KM; Moss AR; Department of Epidemiology and Biostatistics, University of; California, San Francisco General Hospital 94143-1347, USA.; We examined use of the San Francisco needle exchange program NEP) by 1093 injection drug users (IDUs) recruited in methadone maintenance and out-patient detoxification programs in the first 2 years after the opening of the NEP in 1988. Thirty-one percent of IDUs had ever used the NEP. IDUs who were frequent injectors,
Willingness to participate in HIV-1 vaccine efficacy trials and the effect of media events among gay and bisexual men in New York City: Project ACHIEVE.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):165-71. Unique Identifier : AIDSLINE MED/97383126; Koblin BA; Avrett S; Taylor PE; Stevens CE; The Wolf Szmuness Laboratory of Epidemiology, The New York Blood; Center, New York 10021, USA.; Efficacy trials of candidate HIV-1 vaccines require study populations at high risk of infection who adhere to study protocols and who are willing to participate. Data from HIV-1 antibody-negative men (n = 698) enrolled in Project ACHIEVE in New York City were analyzed to assess willingness to participate in efficacy t
HIV-specific cytotoxic T lymphocytes in persons exposed through sexual contact with HIV-infected patients [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):172-3. Unique Identifier : AIDSLINE MED/97383127; Zerhouni B
Effect of HIV-1 genetic diversity on HIV-1 RNA quantification in plasma: comparative evaluation of three commercial assays [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):174-5. Unique Identifier : AIDSLINE MED/97383128; Coste J; Montes B; Reynes J; Peeters M; Segarra C; Delaporte E; Segondy M
Mycobacterial acute lumbosacral polyradiculopathy as the initial manifestation of AIDS [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):175. Unique Identifier : AIDSLINE MED/97383129; Masjuan J; Corral I; Fernandez-Ruiz LC
CD8 T-cell response to antiretroviral therapy [letter; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):176-7. Unique Identifier : AIDSLINE MED/97383130; Stricker RB; Goldberg B
Risk factors for HIV-1 infection among pregnant women in French Guiana [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):177-9. Unique Identifier : AIDSLINE MED/97383131; Cardoso T; Kazanji M; Magnan F; Denoyers H; Talarmin A
Use of protease inhibitors among persons with AIDS in Los Angeles County [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):179-81. Unique Identifier : AIDSLINE MED/97383132; Sorvillo F; Kerndt PR; Odem S; Castillon M; Carruth A; Contreras R
Effects of HIV-1 on the surface expression of LFA-1 on cultured monocytes.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):95-103. Unique Identifier : AIDSLINE MED/97383116; Stent G; Crowe SM; AIDS Pathogenesis Research Unit, National Centre for HIV Virology; Research, Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria, Australia.; CD11a, the alpha chain of LFA-1, which is a member of the LeuCAM family of integrins, has been implicated in the formation of HIV-induced syncytia and may contribute to the depletion of CD4-positive lymphocytes seen in patients with HIV infection. In this study, we examined the effects of HIV-1 infection on the expres
AZT monophosphate knocks thymidylate kinase for a loop [news; comment]: Nat Struct Biol. 1997 Aug;4(8):595-7. Unique Identifier : AIDSLINE MED/97397341; Kenyon GL
Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation [letter] [see comments]: Nat Struct Biol. 1997 Aug;4(8):601-4. Unique Identifier : AIDSLINE MED/97397343; Lavie A; Vetter IR; Konrad M; Goody RS; Reinstein J; Schlichting I
The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.: Nat Struct Biol. 1997 Aug;4(8):657-65. Unique Identifier : AIDSLINE MED/97397355; Huth JR; Bewley CA; Nissen MS; Evans JN; Reeves R; Gronenborn AM; Clore GM; Laboratory of Chemical Physics, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, Maryland 20892-520, USA.; The solution structure of a complex between a truncated form of HMG-I(Y), consisting of the second and third DNA binding domains residues 51-90), and a DNA dodecamer containing the PRDII site of the interferon-beta promoter has been solved by multidimensional nuclear magnetic resonance spectroscopy. The stoichiometry
Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses.: Immunity. 1997 Jul;7(1):123-34. Unique Identifier : AIDSLINE MED/97394407; Rooke R; Waltzinger C; Benoist C; Mathis D; Institut de Genetique et de Biologie Moleculaire et Cellulaire,; Institut National de la Sante et la Recherche Medicale, Universite; Louis Pasteur, Illkirch, Strasbourg, France.; De novo differentiation of CD4+ T cells was provoked in mice lacking major histocompatibility complex (MHC) class II molecules by intrathymic injection of adenovirus vectors carrying class II genes. This permits a new approach to questions concerning the dynamics of CD4+ T cell compartments in the thymus and periphera
Different functions of the GTPase Rho in prothymocytes and late pre-T cells.: Immunity. 1997 Jul;7(1):163-74. Unique Identifier : AIDSLINE MED/97394411; Galandrini R; Henning SW; Cantrell DA; Lymphocyte Activation Laboratory, Imperial Cancer Research Fund; Laboratories, London, United Kingdom.; Mice lacking thymic function of the GTPase Rho show severe defects in fetal and adult thymopoiesis. Rho thymi are deficient in CD44+ CD25+ pro-T cells and CD44- CD25+ early pre-T cells because Rho function is required for survival but not G1/S phase cell cycle progression in these populations. The selective apoptosis
Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles.: Immunity. 1997 Jul;7(1):97-112. Unique Identifier : AIDSLINE MED/97394405; Doolan DL; Hoffman SL; Southwood S; Wentworth PA; Sidney J; Chesnut RW; Keogh E; Appella E; Nutman TB; Lal AA; Gordon DM; Oloo A; Sette A; Malaria Program, Naval Medical Research Institute, Bethesda, Maryland; 20889-5670, USA.; We recently described human leukocyte antigen (HLA) A2, A3 and B7 supertypes, characterized by largely overlapping peptide-binding specificities and represented in a high percentage of different populations. Here, we identified 17 Plasmodium falciparum peptides capable of binding these supertypes and assessed antigeni
[A study of the association between HLA phenotype and serum concentration of soluble HLA class I]: Nihon Rinsho Meneki Gakkai Kaishi. 1997 Apr;20(2):102-7. Unique Identifier : AIDSLINE MED/97322430; Matsuura H; Jimbo S; Miyamura M; Katano M; Togashi K; Matsuda J; Mitsubishi Kagaku Bio--Clinical Laboratories, Inc.; We investigated the association between the phenotypes of human leucocyte antigens (HLA) class I on the surface of lymphocytes and serum concentrations of soluble HLA (sHLA) in normal and Human immunodeficiency virus (HIV) infected subjects. Serum concentrations of sHLA inn normal subjects with HLA-A 24 were significa
Live HIV vaccines--how safe? [letter; comment]: Nat Med. 1997 Aug;3(8):816. Unique Identifier : AIDSLINE MED/97398364; Dittmer U; Stahl-Hennig C; Hunsmann G
Failure of AZT: a molecular perspective [news; comment]: Nat Med. 1997 Aug;3(8):836-7. Unique Identifier : AIDSLINE MED/97398372; Hazuda D; Kuo L
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants [see comments]: Nat Med. 1997 Aug;3(8):849-54. Unique Identifier : AIDSLINE MED/97398376; Roman M; Martin-Orozco E; Goodman JS; Nguyen MD; Sato Y; Ronaghy A; Kornbluth RS; Richman DD; Carson DA; Raz E; Dynavax Technologies Corporation, San Diego, California 92121, USA.; An adjuvant role for certain short bacterial immunostimulatory DNA sequences (ISSs) has recently been proposed on the basis of their ability to stimulate T helper-1 (Th1) responses in gene-vaccinated animals. We report here that noncoding, ISS-enriched plasmid DNAs or ISS oligonucleotides (ISS-ODNs) potently stimulate
Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques.: Nat Med. 1997 Aug;3(8):860-5. Unique Identifier : AIDSLINE MED/97398378; Lang SM; Iafrate AJ; Stahl-Hennig C; Kuhn EM; Nisslein T; Kaup FJ; Haupt M; Hunsmann G; Skowronski J; Kirchhoff F; Institute for Clinical and Molecular Virology, University of; Erlangen-Nuernberg, Erlangen, Germany.; The nef gene of simian immunodeficiency virus (SIV) is essential for high viral load and induction of AIDS in rhesus monkeys. A mutant form of the SIVmac239 Nef, which contains changes in a putative SH3-binding domain (amino acids 104 and 107 have been changed from PxxP to AxxA), does not associate with cellular serin
The bottleneck in AZT activation [see comments]: Nat Med. 1997 Aug;3(8):922-4. Unique Identifier : AIDSLINE MED/97398389; Lavie A; Schlichting I; Vetter IR; Konrad M; Reinstein J; Goody RS; Max Planck Institute for Molecular Physiology, Department of Physical; Biochemistry, Dortmund, Germany.; Nucleoside-based inhibitors of reverse transcriptase were the first drugs to be used in the chemotherapy of AIDS. After entering the cell, these substances are activated to their triphosphate form by cellular kinases, after which they are potent chain terminators for the growing viral DNA. The two main factors limitin
[Cytomegalovirus retinitis in a pediatric AIDS patient]: Rev Neurol. 1997 Jul;25(143):1064-6. Unique Identifier : AIDSLINE MED/97383840; Barrio J; Carbonell P; Minguez E; Gracia-Casanova M; Parra-Formento J; Servicio de Oftalmologia, Hospital Clinico Universitario Lozano Blesa,; Zaragoza, Espana.; INTRODUCTION: Cytomegalovirus retinitis ( CMV ) is the most frequently found opportunistic eye infection in adults with AIDS, with mean incidence of 20%-50%. However, only 5% of children with AIDS have this infection. CLINICAL CASE: We present the case of a six ye
From the natural evolution to the genetic manipulation of the host-range of retroviruses.: Biol Chem. 1997 Jun;378(6):457-68. Unique Identifier : AIDSLINE MED/97368157; Dornburg R; Division of Infectious Diseases, Center for Human Virology, Thomas; Jefferson University, Philadelphia, PA 19107, USA.; The discovery that retroviruses share many features with retrotransposons led to the proposal that retroviruses evolved from cellular movable elements and became independent genetic entities, which started a parasitic life on their own. It has been further hypothesized that in the course of this evolutionary process,
Role of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the treatment of patients with HIV infection.: Curr Opin Hematol. 1997 May;4(3):200-6. Unique Identifier : AIDSLINE MED/97353596; Frumkin LR; University of California at Los Angeles, USA.; The recombinant human colony-stimulating factors, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are hematopoietic cytokines that increase neutrophil number and enhance their function. In patients with HIV infection, G-CSF and GM-CSF have reversed or prevent
Analysis of transcription factor-mediated remodeling of nucleosomal arrays in a purified system.: Methods. 1997 Jul;12(3):276-85. Unique Identifier : AIDSLINE MED/97380382; Steger DJ; Owen-Hughes T; John S; Workman JL; Department of Biochemistry and Molecular Biology, Pennsylvania State; University, University Park 16802-4500, USA.; An early step in a pathway leading to transcriptional initiation involves the rearrangement of chromatin at gene regulatory sequences. To study this process, we have developed a biochemical system analyzing the interactions between chromatin templates composed of arrays of positioned nucleosomes and sequence-specific
Enzyme immunoassays using bispecific diabodies.: Immunotechnology. 1997 Jun;3(2):137-44. Unique Identifier : AIDSLINE MED/97380308; Kontermann RE; Martineau P; Cummings CE; Karpas A; Allen D; Derbyshire E; Winter G; MRC Centre for Protein Engineering, Cambridge, UK.; BACKGROUND: Bispecific antibodies with a first binding specificity to a target antigen and a second to an enzyme have great potential in enzyme immunoassays. As bispecific antibodies are difficult to make, the use of recombinant bispecific antibody fragments may provide a breakthrough. OBJECTIVES: To make bispecific a
Communicable diseases surveillance.: Commun Dis Intell. 1997 Jul 10;21(14):194-202. Unique Identifier : AIDSLINE MED/97391323
Computational study of the conformational domains of peptide T.: J Pept Sci. 1997 Mar-Apr;3(2):85-92. Unique Identifier : AIDSLINE MED/97373990; Filizola M; Centeno NB; Perez JJ; Istituto di Biochimica delle Macromolecole, Seconda Universita degli; Studi di Napoli, Italy.; The conformational preferences of peptide T (ASTTTNYT) were analysed by means of computational methods. A thorough exploration of the conformational space was carried out within the framework of the molecular mechanics approach, using simulated annealing as a searching strategy. Specifically, in order to obtain a subs
Viewing AIDS from a glycobiological perspective: potential linkages to the human fetoembryonic defence system hypothesis.: Mol Hum Reprod. 1997 Jan;3(1):5-13. Unique Identifier : AIDSLINE MED/97383722; Clark GF; Dell A; Morris HR; Patankar M; Oehninger S; Seppala M; Department of Biochemistry, Eastern Virginia Medical School, Norfolk; 23501-1980, USA.; The primary molecular changes that lead to development of acquired immunodeficiency syndrome (AIDS) are very poorly understood, as are the mechanisms underlying the protection of the developing human from the maternal immune response. Recent data that the human immunodeficiency virus (HIV) may be using the glycosylati
Intra-cluster correlation coefficients of 20 infections calculated from the results of cluster-sample surveys.: Prev Vet Med. 1997 Jul;31(1-2):147-50. Unique Identifier : AIDSLINE MED/97378836; Otte MJ; Gumm ID; University of Reading, VEERU, UK.
Incidence and nature of feeding problems in young children referred to a paediatric HIV service in London: FEAD screening.: Child Care Health Dev. 1997 Jul;23(4):297-313. Unique Identifier : AIDSLINE MED/97365786; Melvin D; Wright C; Goddard S; Department of Clinical Health Psychology, St Mary's Hospital, London,; UK.; A detailed screening assessment was carried out on two matched groups of young children; one group was HIV-infected and the other was not. Screening included assessments of growth, development and food intake. Parents were also interviewed about their child s feeding and mealtime behaviours. Half of the HIV-infected c
The Th1/Th2 dichotomy, hsp60 autoimmunity, and type I diabetes.: Clin Immunol Immunopathol. 1997 Aug;84(2):103-6. Unique Identifier : AIDSLINE MED/97401050; Cohen IR; Department of Immunology, Weismann Institute of Science, Rehovot,; Israel.; This paper presents some questions and issues regarding the concept of the Th1/Th2 dichotomy and summarizes results using an hsp60 peptide to treat the spontaneous autoimmune process of diabetes in NOD mice.
Serotonin modulates immune function in T cells from HIV-seropositive subjects.: Clin Immunol Immunopathol. 1997 Aug;84(2):115-21. Unique Identifier : AIDSLINE MED/97401052; Eugen-Olsen J; Afzelius P; Andresen L; Iversen J; Kronborg G; Aabech P; Nielsen JO; Hofmann B; Department of Infectious Diseases 144, Copenhagen University; Hospitals, Hvidovre, Denmark.; We have shown earlier increased intracellular levels of cAMP in peripheral lymphocytes from HIV-seropositive subjects and that a chemically induced decrease in this level increases cell proliferation and cytotoxicity. Others have shown that serotonin indirectly decreases intracellular cAMP levels in normal peripheral
Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase.: Clin Immunol Immunopathol. 1997 Aug;84(2):129-38. Unique Identifier : AIDSLINE MED/97401054; Mazer B; Harbeck RJ; Franklin R; Schwinzer R; Kubo R; Hayward A; Gelfand EW; Department of Pediatrics, National Jewish Center for Immunology and; Respiratory Medicine, Denver, Colorado 80206, USA.; Selective T cell deficiency is a rare immune deficiency characterized by the absence of CD8+ T lymphocytes and depressed/absent T cell function. This syndrome has been associated with mutations in the gene for ZAP-70, a tyrosine kinase that has profound effects on signaling via the T cell receptor. In this paper we de
The presence of antibodies against HIV peptides in the sera of alloimmune mice and thalassemic patients is due to a polyclonal activation mechanism.: Clin Immunol Immunopathol. 1997 Aug;84(2):202-7. Unique Identifier : AIDSLINE MED/97401064; Fraziano M; Montesano C; Lombardi VR; Marchione OP; Colizzi V; Department of Biology, University of Rome Tor Vergata, Italy.; This paper analyses the HIV-1 gp120 epitope specificity and activation mechanisms (i.e., polyclonal versus oligoclonal) of antibodies present in the sera of alloimmune mice and humans. Sera from CBA mice engrafted with C57BL/6 lymphoid cells significantly reacted against the gp120-derived peptide as 261-270, which sha
Ocular flora of patients with AIDS compared with those of HIV-negative patients.: Cornea. 1997 Jul;16(4):400-5. Unique Identifier : AIDSLINE MED/97363944; Gritz DC; Scott TJ; Sedo SF; Cevallos AV; Margolis TP; Whitcher JP; King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.; PURPOSE: To determine whether there are quantitative or qualitative differences in the ocular flora of patients with acquired immunodeficiency syndrome (AIDS) compared with human immunodeficiency virus (HIV)-negative patients. METHODS: Forty patients with AIDS and 42 HIV-negative controls were sex and age matched. All
[The advantages of protease inhibitors in the battle against HIV news)]: Dtsch Med Wochenschr. 1997 Jul 25;122(30):A25. Unique Identifier : AIDSLINE MED/97424132
The role of advanced generation macrolides in the prophylaxis and treatment of Mycobacterium avium complex (MAC) infections.: Drugs. 1997 Jul;54(1):69-80. Unique Identifier : AIDSLINE MED/97354886; Amsden GW; Peloquin CA; Berning SE; Bassett Healthcare, Department of Pharmacy Services, Cooperstown, New; York, USA.; Since the start of the acquired immunodeficiency syndrome (AIDS) epidemic, the role of Mycobacterium avium complex (MAC) as an opportunistic pathogen in advanced AIDS patients has become more and more clear. Once identified in an advanced AIDS patient it is possible to find evidence that the MAC organism and infection
Caspase activity is required for commitment to Fas-mediated apoptosis.: EMBO J. 1997 Jul 1;16(13):3805-12. Unique Identifier : AIDSLINE MED/97377019; Longthorne VL; Williams GT; Department of Biological Sciences, Keele University, Staffordshire,; UK.; Recognition of the widespread importance of apoptosis has been one of the most significant changes in the biomedical sciences in the past decade. The molecular processes controlling and executing cell death through apoptosis are, however, still poorly understood. The ICE (Interleukin-1beta Converting Enzyme) family-re
Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence.: EMBO J. 1997 Jul 16;16(14):4276-84. Unique Identifier : AIDSLINE MED/97392457; Dobbelstein M; Roth J; Kimberly WT; Levine AJ; Shenk T; Howard Hughes Medical Institute, Princeton University, NJ 08544-1014,; USA.; The E1B 55-kDa and E4 34-kDa oncoproteins of adenovirus type 5 abbreviated here as E1B-55kD and E4-34kD) promote the export of viral mRNA and inhibit the export of most cellular mRNA species. We show that the intracellular complex containing E1B-55kD and E4-34kD continuously shuttles between the nucleus and the cytopl
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.: FEBS Lett. 1997 Jun 30;410(2-3):324-8. Unique Identifier : AIDSLINE MED/97379333; Balzarini J; Kruining J; Wedgwood O; Pannecouque C; Aquaro S; Perno CF; Naesens L; Witvrouw M; Heijtink R; De Clercq E; McGuigan C; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; 2 ,3 -Dideoxyadenosine (ddA), 2 ,3 -didehydro-2 ,3 -dideoxyadenosine (d4A) and their lipophilic 5 -monophosphate triester (aryloxyphosphoramidate) prodrugs were evaluated for their anti-retrovirus and anti-hepatitis B virus activity in various cell culture models. The aryloxyphosphoramidate derivatives of ddA (Cf 1093
[Infection with HTLV virus type I-II in patients with cervico-uterine cancer in the Yucatan peninsula, Mexico]: Ginecol Obstet Mex. 1997 Apr;65:141-4. Unique Identifier : AIDSLINE MED/97328929; Gongora-Biachi RA; Gonzalez-Martinez P; Castro-Sansores C; Bastarrachea-Ortiz J; Laboratorio de Hematologia, Centro de Investigaciones Regionales Dr.; Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Mexico.; Southwestern Japan is an endemic zone with high prevalence of HTLV-I infection. In addition, a relation between cancer of the cervix and this retrovirus has been described. A recent study has demonstrated a low prevalence of HTLV-I/II infection in Yucatan,
[Prognosis depends on viral load. AIDS: frequently too much time is wasted (news)]: Fortschr Med. 1997 Jun 10;115(16):14. Unique Identifier : AIDSLINE MED/97374089
[Hope for delaying demise]: Fortschr Med. 1997 Jun 10;115(16):66-9. Unique Identifier : AIDSLINE MED/97374095; Wagner B
Follicular dendritic cells (FDC) in retroviral infection: host/pathogen perspectives.: Immunol Rev. 1997 Apr;156:185-97. Unique Identifier : AIDSLINE MED/97319820; Burton GF; Masuda A; Heath SL; Smith BA; Tew JG; Szakal AK; Department of Microbiology and Immunology, Medical College of; Virginia, Virginia Commonwealth University, Richmond, USA.; gburton@gems.vcu.edu; Follicular dendritic cells (FDC) are found in the follicles of virtually all secondary lymphoid tissues. In health, these cells trap and retain antigens (Ag) in the form of immune complexes and preserve them for months in their native conformation. FDC thus serve as a long-term repository of extracellular Ag important
Phenotypic changes of monocytes induced by HIV-1 gp120 molecule and its fragments.: Immunobiology. 1997 Jun;197(1):110-21. Unique Identifier : AIDSLINE MED/97385521; Zembala M; Bach S; Szczepanek A; Mancino G; Colizzi V; Department of Clinical Immunology, Jagiellonian University Medical; School, Cracow, Poland. mizembal@cyf-kr.edu.pl; Several phenotypic and functional changes of monocytes (M phi) have been described in HIV-1+ subjects and AIDS patients. Some of these changes that are pertinent for immunopathogenesis of the disease may be induced by HIV-1 envelope glycoprotein 120 gp120). In the present study the effect of recombinant full length gp
Spectrum of liver diseases in HIV infection.: Indian J Gastroenterol. 1997 Jul;16(3):94-5. Unique Identifier : AIDSLINE MED/97391373; Rathi PM; Amarapurkar DN; Borges NE; Koppikar GV; Kalro RH; Department of Gastroenterology, T N Medical College, Mumbai.; BACKGROUND: Most earlier reports on the spectrum of liver diseases in HIV-infected individuals originated from the West. OBJECTIVE: To study the spectrum of liver diseases in HIV-infected individuals. METHODS: Seventy four consecutive HIV-positive patients (57 men; age range 23-75 years, mean 34) were studied prospect
Alpha EEG activity and subcortical pathology in HIV infection.: Int J Psychophysiol. 1997 Jun;26(1-3):431-42. Unique Identifier : AIDSLINE MED/97346602; Baldeweg T; Gruzelier JH; Academic Department of Psychiatry, Charing Cross and Westminster; Medical School, London, UK.; Quantitative electroencephalographic (QEEG) investigations of patients with HIV-1-infections were made to detect early signs of HIV brain involvement. QEEG data were recorded in a prospective controlled cohort study together with standardised clinical, immunological and neuropsychological tests. Subject groups were HI
What's on the Internet? Services for women affected by HIV and AIDS.: Health Care Women Int. 1997 May-Jun;18(3):315-22. Unique Identifier : AIDSLINE MED/97400818; Mallory C; School of Nursing, Indiana University, Department of Family Nursing,; Indianapolis 46202-5107, USA. cmallor1@prairienet.org; In this article I report findings from a survey of Internet sites related to HIV and AIDS with a special focus on women. HIV and AIDS are serious threats to the health of women, but little has been published about the cultural, economic, and social environments in which these women reside, and how these environments r
HIV and the heart.: J Assoc Physicians India. 1996 Nov;44(11):815-9. Unique Identifier : AIDSLINE MED/97395207; Sankaran JR
Toxoplasma encephalitis in AIDS.: J Assoc Physicians India. 1996 Nov;44(11):838. Unique Identifier : AIDSLINE MED/97395215; Handa R; Wali JP; Kaushik P; Gupta R; Singh S; Gambhir M; Wig N; Biswas A; Aggarwal P; Department of Medicine, All India Institute of Medical Sciences, New; Delhi.
HIV/AIDS epidemic in India: the past decade (1986-96) and future scenario [editorial]: J Assoc Physicians India. 1996 Apr;44(4):235-6. Unique Identifier : AIDSLINE MED/97395139; Chogle AR
A comparative study of the awareness and attitude of HIV/AIDS among students living in India and migrants to the United States.: J Assoc Physicians India. 1996 Apr;44(4):237-9. Unique Identifier : AIDSLINE MED/97395140; Chakraborty J; Purohit A; Shah S; Kalla S; Department of Physiology and Molecular Medicine, Medical College of; Ohio, Toledo, USA.; The goal of the current study was to collect preliminary data regarding HIV/AIDS awareness among Indian students who are residing in India and those who have migrated to the United States . A questionnaire was distributed to thirty-four college students in the United States and thirty-e
Nephrologic aspects of HIV infection.: J Assoc Physicians India. 1996 Apr;44(4):259-60, 265-6. Unique Identifier : AIDSLINE MED/97395148; Singh NP; Rohatgi A; Dept of Medicine, Maulana Azad Medical College, New Delhi.
False negative ELISA in an Indian truck driver with AIDS.: J Assoc Physicians India. 1996 Apr;44(4):281-2. Unique Identifier : AIDSLINE MED/97395155; Varma S; Sehgal S; Varma N; Kumar B; Sharma BK; Department of Internal Medicine, Postgraduate Institute of Medical; Education and Research, Chandigarh.
Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions.: J Biol Chem. 1997 Aug 15;272(33):20420-6. Unique Identifier : AIDSLINE MED/97400515; Alkhatib G; Berger EA; Murphy PM; Pease JE; Laboratory of Viral Diseases, NIAID, National Institutes of Health,; Bethesda, Maryland 20892, USA.; The chemokine receptors CXCR4, CCR2b, CCR3, and CCR5 are cell entry coreceptors for HIV-1. Using an HIV-1 envelope Env)-dependent cell-cell fusion model of entry, we show that CCR3 can interact with Envs from certain macrophage (M)-tropic strains (which also use CCR5), T cell line (TCL)-tropic laboratory-adapted strai
Cationic liposome-mediated uptake of human immunodeficiency virus type 1 Tat protein into cells.: J Virol Methods. 1997 Jun;66(1):149-57. Unique Identifier : AIDSLINE MED/97364123; Fong SE; Smanik P; Smith MC; Jaskunas SR; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN; 46285-0438, USA. Fong@mail.ncifcrf.gov; The human immunodeficiency virus type 1 (HIV-1) Tat protein strongly transactivates gene expression from the viral long terminal repeat (LTR) and is required for virus efficient replication. Previous studies have shown that cells scrape-loaded in the presence of purified recombinant Tat can absorb the protein in a rec
HEp-2 cell adherence patterns, serotyping, and DNA analysis of Escherichia coli isolates from eight patients with AIDS and chronic diarrhea.: J Clin Microbiol. 1997 Aug;35(8):1952-8. Unique Identifier : AIDSLINE MED/97373879; Polotsky Y; Nataro JP; Kotler D; Barrett TJ; Orenstein JM; Department of Pathology, George Washington University Medical Center,; Washington, DC 20037, USA.; Three morphologic patterns of interaction between bacteria and enterocytes have been observed in colonic biopsy specimens from AIDS patients with chronic diarrhea in the United States . The DNA encoding virulence factors and the HEp-2 cell adherence patterns of Escherichia coli strains
Pseudo-outbreak of septicemia due to rapidly growing mycobacteria associated with extrinsic contamination of culture supplement.: J Clin Microbiol. 1997 Aug;35(8):2040-2. Unique Identifier : AIDSLINE MED/97373894; Ashford DA; Kellerman S; Yakrus M; Brim S; Good RC; Finelli L; Jarvis WR; McNeil MM; Division of Bacterial and Mycotic Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Between April and December 1994, 23 blood cultures from human immunodeficiency virus-infected patients grew rapidly growing mycobacteria suspected to be Mycobacterium chelonae at a hospital in New Jersey. The isolates were later identified as M. abscessus. Several bacterial species, including M. abscessus, were cultur
Detection and identification of mycobacteria by amplification of RNA and DNA in pretreated blood and bone marrow aspirates by a simple lysis method.: J Clin Microbiol. 1997 Aug;35(8):2124-8. Unique Identifier : AIDSLINE MED/97373912; Gamboa F; Manterola JM; Lonca J; Matas L; Vinado B; Gimenez M; Cardona PJ; Padilla E; Ausina V; Servicio de Microbiologia, Hospital Universitario Germans Trias i; Pujol, Badalona, Barcelona, Spain.; A sodium dodecyl (lauryl) sulfate method was evaluated for the preparation of blood specimens and bone marrow aspirates for use in two amplification procedures (Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test [AMTDT] and Roche Amplicor M. avium/M. intracellulare [MAI] Test) for the detection and identificat
Invasive amoebiasis in two patients with AIDS and cytomegalovirus colitis.: J Clin Microbiol. 1997 Aug;35(8):2168-9. Unique Identifier : AIDSLINE MED/97373925; Fatkenheuer G; Arnold G; Steffen HM; Franzen C; Schrappe M; Diehl V; Salzberger B; Department of Internal Medicine I, University of Cologne, Germany.; G.Faetkenheuer@uni-koeln.de; Homosexual persons or human immunodeficiency virus (HIV)-infected patients frequently excrete cysts of nonpathogenic strains of Entamoeba histolytica ( Entamoeba dispar ). However, invasive amoebiasis is rare. We report two patients with AIDS and cytomegalovirus colitis in whom inv
The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection.: J Clin Invest. 1997 Aug 1;100(3):497-502. Unique Identifier : AIDSLINE MED/97386611; Frade JMR; Llorente M; Mellado M; Alcami J; Gutierrez-Ramos JC; Zaballos A; Real G; Martinez-A C; Department of Immunology and Oncology, Centro Nacional de; Biotecnologia, Consejo Superior de Investigaciones Cientificas,; Universidad Autonoma de Madrid, Campus de Cantoblanco, E-28049 Madrid,; Spain.; The chemokines are a homologous serum protein family characterized by their ability to induce activation of integrin adhesion molecules and leukocyte migration. Chemokines interact with their receptors, which are composed of a single-chain, seven-helix, membrane-spanning protein coupled to G proteins. Two CC chemokine
Microglial production of TNF-alpha is induced by activated T lymphocytes. Involvement of VLA-4 and inhibition by interferonbeta-1b.: J Clin Invest. 1997 Aug 1;100(3):604-12. Unique Identifier : AIDSLINE MED/97386624; Chabot S; Williams G; Yong VW; Neuroimmunology Unit, Department of Neurology and Neurosurgery, McGill; University, Montreal Neurological Institute, Montreal, Quebec, Canada; H3A 2B4.; TNF-alpha is a proinflammatory cytokine involved in many inflammatory conditions such as Crohn s disease, rheumatoid arthritis, cachexia, AIDS, and multiple sclerosis (MS). TNF-alpha is produced mainly by cells of the macrophage lineage, which includes microglia in the central nervous system. Here, we describe a mecha
Concurrent cytomegalovirus, M. tuberculosis and M. avium-intracellulare cutaneous infection in an HIV patient.: J Dermatol. 1997 Jun;24(6):401-4. Unique Identifier : AIDSLINE MED/97385955; Nunez M; Miralles ES; Hilara Y; Pintado V; Harto A; Ledo A; Servicio de Dermatologia, Hospital Ramon y Cajal, Universidad de; Alcala Madrid, Spain.; We report a 25-year-old HIV-positive man with a past medical history of disseminated cytomegalovirus ( CMV ) infection, who developed cutaneous lesions during a disseminated mycobacterium infection. The histological changes of
TH1 and TH2 CD4+ cells in human allergic diseases.: J Allergy Clin Immunol. 1997 Jul;100(1):1-6. Unique Identifier : AIDSLINE MED/97400285; Umetsu DT; DeKruyff RH; Department of Pediatrics, Stanford University, Calif, 94305-5119, USA.
Nosocomial infections in HIV-infected patients: preliminary results from a multicenter surveillance system (1989-1995).: Infect Control Hosp Epidemiol. 1997 Jul;18(7):479-85. Unique Identifier : AIDSLINE MED/97390995; Stroud L; Srivastava P; Culver D; Bisno A; Rimland D; Simberkoff M; Elder H; Fierer J; Martone W; Gaynes R; Hospital Infections Program, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; OBJECTIVE: To describe the characteristics of and trends in nosocomial infection among human immunodeficiency virus HIV)-infected patients. DESIGN: Multicenter prospective cohort study. SETTING/PATIENTS: HIV-infected patients were enrolled at time of first inpatient admission at five Veterans Administration Medical C
HIV infection in obstetrics and gynaecology.: J Indian Med Assoc. 1997 Jan;95(1):14, 26. Unique Identifier : AIDSLINE MED/97356089; Bhattacharyya PK; Eden Hospital, Medical College, Calcutta.
Knowledge and attitude in relation to HIV/AIDS among in-service nurses of Calcutta.: J Indian Med Assoc. 1997 Mar;95(3):75-7. Unique Identifier : AIDSLINE MED/97356101; Datta C; Bandyopadhyay D; Medical College, Calcutta.; Seventy-five senior nurses attending a workshop were surveyed with questionnaires and using two separate scales, their knowledge about transmission and precautionary measures, and their general attitude towards HIV/AIDS as well as willingness for patient-care were assessed. The nurses showed a satisfactory level of kn
Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia.: J Pain Symptom Manage. 1997 Jul;14(1):7-14. Unique Identifier : AIDSLINE MED/97367046; Beal JE; Olson R; Lefkowitz L; Laubenstein L; Bellman P; Yangco B; Morales JO; Murphy R; Powderly W; Plasse TF; Mosdell KW; Shepard KV; St. John's Hospital, Tulsa, Oklahoma, USA.; We studied the effects of long-term (12 months) dronabinol in 94 late-stage acquired immunodeficiency syndrome (AIDS) patients mean CD4 count of 45/mm3) who previously participated in a 6-week study (placebo versus dronabinol). All patients received dronabinol orally-2.5 mg twice daily (90%) or 2.5 mg once daily 10%).
Comprehensive investigation of the presence of JC virus in AIDS patients with and without progressive multifocal leukoencephalopathy.: J Med Virol. 1997 Jul;52(3):235-42. Unique Identifier : AIDSLINE MED/97353789; Ferrante P; Caldarelli-Stefano R; Omodeo-Zorini E; Cagni AE; Cocchi L; Suter F; Maserati R; Institute of Medical Microbiology, University of Milan, Italy.; Progressive multifocal leukoencephalopathy (PML), a viral-induced demyelinating disease, is becoming relatively common, while many diagnostic and pathogenetic aspects remain to be clarified. A study was therefore undertaken in 64 AIDS patients suffering from various neurological disorders, including PML (12 subjects),
Detection of archetype and rearranged variants of JC virus in multiple tissues from a pediatric PML patient.: J Med Virol. 1997 Jul;52(3):243-52. Unique Identifier : AIDSLINE MED/97353790; Newman JT; Frisque RJ; Department of Biochemistry and Molecular Biology, Pennsylvania State; University, University Park 16802, USA.; JC virus (JCV) establishes persistent infections in its human host, and in some immunocompromised individuals, the virus causes the fatal brain disease progressive multifocal leukoencephalopathy (PML). Two forms of the virus, archetype and rearranged, have been isolated, with the latter being derived from the archetyp
Temporal development and prognostic value of antibody response to the major neutralizing epitopes of gp120 during HIV-1 infection.: J Med Virol. 1997 Jul;52(3):309-15. Unique Identifier : AIDSLINE MED/97353800; Turbica I; Simon F; Besnier JM; LeJeune B; Choutet P; Goudeau A; Barin F; Laboratoire de Virologie, CHU Bretonneau, Tours, France.; Our objective was to analyse the humoral response to the major neutralizing epitopes of gp120. The kinetics of the appearance of antibodies directed to the V3 region (V3 Abs) and antibodies directed to the CD4 binding site (CD4BS Abs) were compared in sequential sera from 20 seroconverters. V3 Abs were titrated using
Prevalence of antibodies to HTLV in antenatal clinic attenders in south east London.: J Med Virol. 1997 Jul;52(3):326-9. Unique Identifier : AIDSLINE MED/97353803; Hale A; Leung T; Sivasubramaniam S; Kenny J; Sutherland S; King's College School of Medicine and Dentistry, Dulwich Hospital,; London, United Kingdom.; The prevalence of antibodies to HTLV in women attending a south east London antenatal clinic between October 1990 and July 1992 was determined using sera referred for routine rubella antibody testing. Samples were screened for HTLV antibody using a modified Fujirebio gel particle agglutination test and reactive sera c
A way to screen for suffering in palliative care.: J Palliat Care. 1997 Summer;13(2):22-6. Unique Identifier : AIDSLINE MED/97375254; Bayes R; Limonero JT; Barreto P; Comas MD; Autonomous University of Barcelona, Spain.; We report a new tool for screening the suffering of terminally ill patients in a palliative care service. We systematically asked 371 terminal oncological and AIDS patients on 665 different occasions, How long did yesterday seem to you? ; we then asked them to assess their current condition. The simple answer about s
"Alan".: J Palliat Care. 1997 Summer;13(2):43-4. Unique Identifier : AIDSLINE MED/97375257; Jamieson SP
Multicentre study on the prevalence of symptoms and symptomatic treatment in HIV infection. Central Italy PRESINT Group.: J Palliat Care. 1997 Summer;13(2):9-13. Unique Identifier : AIDSLINE MED/97375252; Fantoni M; Ricci F; Del Borgo C; Izzi I; Damiano F; Moscati AM; Marasca G; Bevilacqua N; Del Forno A; Department of Infectious Diseases, Catholic University of the Sacred; Heart, Rome, Italy.; We investigated the prevalence and intensity of symptoms and the use of drugs for symptom control among all HIV-infected patients reporting to the outpatient clinics or wards of 15 clinical centres in central Italy , recording clinical and epidemiological data on three consecutive da
Notification of tuberculosis: an updated code of practice for England and Wales.: J R Coll Physicians Lond. 1997 May-Jun;31(3):299-303. Unique Identifier : AIDSLINE MED/97335667; Ormerod LP; Watson JM; Pozniak A; Kumar D; McManus T; Communicable Disease Surveillance Centre, London.
Tuberculosis: a spectre has returned [news]: J R Soc Health. 1997 Apr;117(2):73. Unique Identifier : AIDSLINE MED/97367053
Knowledge and attitudes to HIV and AIDS and sexual practices among university students in Lusaka, Zambia and London, England: are they so different?: J R Soc Health. 1997 Apr;117(2):88-94. Unique Identifier : AIDSLINE MED/97367056; Baggaley R; Drobniewski F; Pozniak A; Chipanta D; Tembo M; Godfrey-Faussett P; Kara Counselling and Training Trust Lusaka, Zambia.
Synthesis and anti-HIV-1 activity of a series of 1-alkoxy-5-alkyl-6-(arylthio)uracils.: J Med Chem. 1997 Jul 18;40(15):2363-73. Unique Identifier : AIDSLINE MED/97384683; Kim DK; Gam J; Kim YW; Lim J; Kim HT; Kim KH; Life Science Research Center, Sunkyong Industries, Kyunghi-Do, Korea.; A series of 1-alkoxy-5-alkyl-6-(arylthio)uracils was synthesized and tested for their ability to inhibit HIV-1 replication. Treatment of 2-alkyl-3,3-bis(methylthio)acryloyl chlorides (5a-e) with AgOCN in benzene followed by reaction of the resulting isocyanates 6a-e with an appropriate alkoxyamine gave N-alkoxy-N -((2
The human T-cell lymphotropic viruses types I/II are not involved in T prolymphocytic leukemia and large granular lymphocytic leukemia.: Leukemia. 1997 Aug;11(8):1305-11. Unique Identifier : AIDSLINE MED/97407636; Pawson R; Schulz TF; Matutes E; Catovsky D; Department of Academic Hematology and Cytogenetics, Royal Marsden; Hospital, London, UK.; The possible involvement of the human T lymphotropic viruses type I and II (HTLV-I and -II) in lymphoproliferative disorders of mature T cells other than adult T cell leukemia/lymphoma (ATLL) has been controversial. Most studies have focused primarily on the cutaneous T cell lymphomas. However, skin involvement is a f
Differential immunologic modulatory effects of tetrahydrocannabinol as a function of age.: Mech Ageing Dev. 1997 Jun;96(1-3):117-26. Unique Identifier : AIDSLINE MED/97366305; Ramarathinam L; Pross S; Plescia O; Newton C; Widen R; Friedman H; Department of Medical Microbiology and Immunology, University of South; Florida College of Medicine, Tampa 33612, USA.; Tetrahydrocannabinol (THC) the major psychoactive component of marijuana, differentially modulates the immune response of lymphoid cells from young and old mice. This effect was previously shown when cells from mice of different ages were treated with THC in vitro. In the present study THC was given in vivo to mice of
HIV infection and aging: mechanisms to explain the accelerated rate of progression in the older patient.: Mech Ageing Dev. 1997 Jun;96(1-3):137-55. Unique Identifier : AIDSLINE MED/97366307; Adler WH; Baskar PV; Chrest FJ; Dorsey-Cooper B; Winchurch RA; Nagel JE; Gerontology Research Center, NIA, NIH, Baltimore, MD 21224, USA.; whadler@vax.grc.nia.nih.gov; Age is an important predictor of progression in HIV infections. Not only do older individuals develop AIDS more rapidly than younger persons, they die more quickly after developing an AIDS-defining illness. While the elderly have higher morbidity and mortality rates from viral and bacterial infections, the mechanism(
Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice.: Mech Ageing Dev. 1997 Jun;96(1-3):181-96. Unique Identifier : AIDSLINE MED/97366310; Miller RA; Department of Pathology and Geriatrics Center, University of Michigan; School of Medicine, Ann Arbor 48109-0642, USA. millerr@umich.edu; In a longitudinal design in which each animal was examined repeatedly throughout its life, we used flow cytometry to determine the numbers or proportions of a variety of T lymphocyte subsets in the peripheral blood of mice aged 8-20 months. Half of the 128 mice were given a low calorie diet which is known to extend li
Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus afflicted mice.: Mech Ageing Dev. 1997 Jun;96(1-3):47-58. Unique Identifier : AIDSLINE MED/97366300; Segal R; Dayan M; Globerson A; Habut B; Shearer GM; Mozes E; Department of Immunology, Weizmann Institute of Science, Rehovot,; Israel.; The objective of the this study was to determine the cytokine profile of aging mice and to establish whether changes in cytokine production account for the fact that aging mice develop a milder disease than the young in response to induced experimental systemic lupus erythematosus (SLE). Cytokine secretion was evaluat
[Anti-retrovirals]: Med Clin (Barc). 1997 Jun 7;109(2):62-7. Unique Identifier : AIDSLINE MED/97358952; Roca B; Simon E; Unidad de Enfermedades infecciosas, Hosptial General de Castellon.
[IgA nephropathy associated with human immunodeficiency virus infection. Description of a case (letter)]: Med Clin (Barc). 1997 Jun 7;109(2):77-8. Unique Identifier : AIDSLINE MED/97358957; Nicolas Sanchez FJ; Ramos Nanez J; Gazquez Sistere I; Rubio Caballero M
[Multi-resistant tuberculosis of fatal outcome in a patient without HIV infection (letter)]: Med Clin (Barc). 1997 Jun 7;109(2):78-9. Unique Identifier : AIDSLINE MED/97358958; Pulido F; Moreno V; Mateo S; Palenque E
New AIDS drugs affect US state assistance [news]: Lancet. 1997 Jul 19;350(9072):195. Unique Identifier : AIDSLINE MED/97393761; Firshein J
Late postnatal transmission of HIV-1 and early weaning [letter; comment]: Lancet. 1997 Jul 19;350(9072):221. Unique Identifier : AIDSLINE MED/97393777; Van de Perre P; Meda N; Cartoux M; Leroy V; Dabis F
Representation and analysis of medical decision problems with influence diagrams [see comments]: Med Decis Making. 1997 Jul-Sep;17(3):241-62. Unique Identifier : AIDSLINE MED/97362721; Owens DK; Shachter RD; Nease RF Jr; VA Palo Alto Health Care System, Section of General Medicine, CA; 94304, USA.; Influence diagrams are a powerful graphic representation for decision models, complementary to decision trees. Influence diagrams and decision trees are different graphic representations for the same underlying mathematical model and operations. This article describes the elements of an influence diagram, and shows se
Making treatment decisions with HIV infection: a pilot study of patient preferences.: Med Decis Making. 1997 Jul-Sep;17(3):307-14. Unique Identifier : AIDSLINE MED/97362727; Rosenfeld BD; White M; Passik SD; Department of Psychiatry, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA.; The importance of understanding patient preferences in making treatment decisions is widely recognized. This pilot study utilized a forced-choice paired-comparison method in which 28 ambulatory HIV-infected patients were given a computer-generated presentation of all possible pairs of eight different treatment options
HIV risk assessment: a video doctor seeks patient disclosure.: MD Comput. 1997 Jul-Aug;14(4):288-94. Unique Identifier : AIDSLINE MED/97374141; Gerbert B; Johnston K; Bleecker T; Bronstone A; Flatt S; Allerton M; Caspers N; We assessed the influence of a video doctor s affective communication style (warm vs. neutral) and of a preamble to questions about sexual activity on patients disclosure of risky sexual behavior and injectable drug use. To isolate the effects of the independent variables, we created an interactive multimedia progr
Development of an HIV clinical and research database for South Africa.: Methods Inf Med. 1997 Feb;36(2):144-8. Unique Identifier : AIDSLINE MED/97386000; Kanter AS; Spencer DC; Steinberg MH; Wolfson College, Cambridge U.K. ask21@hermes.cam.ac.uk; Health service restructuring in South Africa provides an opportunity to introduce appropriate Health Information System HIS) technology. This is particularly relevant given the emerging HIV epidemic and the need to capture, translate and disseminate new experiences in HIV/AIDS car
Amplifiable hybridization probes containing a molecular switch.: Mol Cell Probes. 1997 Jun;11(3):187-94. Unique Identifier : AIDSLINE MED/97376507; Blok HJ; Kramer FR; Department of Molecular Genetics, Public Health Research Institute,; New York, NY 10016, USA.; In order to reduce background signals in Q beta replicase-mediated bioassays, a target-dependent probe amplification strategy has been proposed that utilizes recombinant RNA hybridization probes that contain an inserted molecular switch. A molecular switch is an internal region of the probe that undergoes a conformati
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-1997. A 38-year-old man with the acquired immunodeficiency syndrome and cavitary pulmonary lesions [clinical conference]: N Engl J Med. 1997 Aug 28;337(9):619-27. Unique Identifier : AIDSLINE MED/97398288
Cerebral microsporidiosis due to Encephalitozoon cuniculi [letter; comment]: N Engl J Med. 1997 Aug 28;337(9):640-1. Unique Identifier : AIDSLINE MED/97398300; Guntinas-Lichius O
Interferon alfa treatment of a patient with eosinophilic cellulitis and HIV infection [letter]: N Engl J Med. 1997 Aug 28;337(9):641-2. Unique Identifier : AIDSLINE MED/97398301; Husak R; Goerdt S; Orfanos CE
Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis.: Neuropathol Appl Neurobiol. 1997 Jun;23(3):242-53. Unique Identifier : AIDSLINE MED/97366324; Krajewski S; James HJ; Ross J; Blumberg BM; Epstein LG; Gendelman HE; Gummuluru S; Dewhurst S; Sharer LR; Reed JC; Gelbard HA; Burnham Institute, La Jolla, CA, USA.; We have previously demonstrated the presence of DNA fragmentation in neurons, macrophages and microglia consistent with apoptosis, but not in reactive astrocytes in brain tissue from paediatric patients with HIV-1 encephalitis (HIVE). To further understand the underlying mechanism(s) for these findings as they relate
Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders.: Neurology. 1997 Jul;49(1):142-6. Unique Identifier : AIDSLINE MED/97365345; Cognitive impairment is a common and disabling complication of advanced HIV infection. Antiretroviral agents are the only proven therapies currently used for the treatment of HIV dementia , but the response to these agents is frequently unsatisfactory, short-lived, or complicated by
Peripheral neuropathy in children with HIV infection.: Neurology. 1997 Jul;49(1):207-12. Unique Identifier : AIDSLINE MED/97365355; Floeter MK; Civitello LA; Everett CR; Dambrosia J; Luciano CA; EMG Section, National Cancer Institute, NIH, Bethesda, MD 20892, USA.; Peripheral neuropathy is infrequently reported in children with HIV infection, but may be underrecognized. To provide a better understanding of the patterns of peripheral neuropathy in these children, we surveyed the charts of 50 children with HIV infection referred t
Progressive multifocal leukoencephalopathy presenting as human immunodeficiency virus type 1 (HIV)-associated dementia.: Neurology. 1997 Jul;49(1):263-5. Unique Identifier : AIDSLINE MED/97365367; Zunt JR; Tu RK; Anderson DM; Copass MC; Marra CM; Department of Neurology, University of Washington School of Medicine,; Seattle, USA.; Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder of the CNS that usually causes hemiparesis or hemianopsia. Dementia occurs in combination with other neurologic abnormalities. We report a human immunodeficiency virus type 1 (HIV)-infected man whose only manifestation of proven PML was
HIV drug dilemma--triple threat.: Nursing. 1997 Jul;27(7):20. Unique Identifier : AIDSLINE MED/97421643; Cohen MR
Immune compromise and prevalence of Candida vulvovaginitis in human immunodeficiency virus-infected women.: Obstet Gynecol. 1997 Aug;90(2):252-6. Unique Identifier : AIDSLINE MED/97385271; Duerr A; Sierra MF; Feldman J; Clarke LM; Ehrlich I; DeHovitz J; Division of Reproductive Health, National Center for Chronic Disease; Prevention and Health Promotion, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; OBJECTIVE: To investigate the effect of human immunodeficiency virus (HIV) infection on vaginal yeast colonization and symptomatic vulvovaginitis and to explore the effects of immune compromise on these conditions in HIV-positive women. METHODS: Between September 1991 and May 1
Nasopharyngeal pneumococcal colonization among Kenyan children: antibiotic resistance, strain types and associations with human immunodeficiency virus type 1 infection.: Pediatr Infect Dis J. 1997 Jul;16(7):656-62. Unique Identifier : AIDSLINE MED/97383800; Rusen ID; Fraser-Roberts L; Slaney L; Ombette J; Lovgren M; Datta P; Ndinya-Achola J; Talbot JA; Nagelkerke N; Plummer FA; Embree JE; Department of Medical Microbiology, University of Manitoba, Winnipeg,; Canada.; OBJECTIVES: To compare pneumococcal nasopharyngeal colonization rates among HIV-1-infected children with those of uninfected children born to seropositive mothers and those of seronegative controls. To determine the predominant serotypes and antimicrobial susceptibility among pneumococcal isolates in
Human intravenous immunoglobulin in primary and secondary antibody deficiencies.: Pediatr Infect Dis J. 1997 Jul;16(7):696-707. Unique Identifier : AIDSLINE MED/97383805; Stiehm ER; Division of Immunology/Allergy/Rheumatology, UCLA Childrens Hospital; 90095, USA; IVIG is of value in patients with primary and secondary antibody deficiencies. High dose IVIG therapy is usually the treatment of choice for patients with primary antibody deficiency disease. Sufficient IVIG should be given to maintain IgG trough levels of > 500 mg/dl; this usually requires a dose of 400 to 500 mg/kg/
Immunity to Haemophilus influenzae type b after reimmunization with oligosaccharide CRM197 conjugate vaccine in children with human immunodeficiency virus infection.: Pediatr Infect Dis J. 1997 Jul;16(7):711-3. Unique Identifier : AIDSLINE MED/97383808; Peters VB; Sood SK; Department of Pediatrics, Mount Sinai School of Medicine, New York, NY; 10029, USA. Vicki_Peters@SMTPLINK.MSSM.EDU
Where reality meets methodology in conducting nursing intervention research with women.: Nurs Res. 1997 Jul-Aug;46(4):240-3. Unique Identifier : AIDSLINE MED/97404587; Harris RM; Dennis KE; University of Maryland at Baltimore School of Nursing, Health Science; Facilities, Baltimore, MD 21201, USA.
[Course of mother-child relations in cases of maternal HIV infection]: Pediatr Med Chir. 1997 Jan-Feb;19(1):23-5. Unique Identifier : AIDSLINE MED/97366372; Astori MG; Piazza F; Maccabruni A; Caselli D; Lanzi G; Istituto Neurologico C. Mondino di Pavia, Italia.; 32 children born from HIV infected mothers (8 HIV infected and 24 seroreverted uninfected) were followed up from 1990 to 1995 at the Neurological Institute C. Mondino in Pavia to study the mother and baby relationship. At the end of the follow-up period, from the birth to the end of the second year of age, all child
[AIDS in children: diagnostic imaging of pulmonary and abdominal lesions. Review of the literature and personal experience]: Radiol Med (Torino). 1997 May;93(5):497-503. Unique Identifier : AIDSLINE MED/97395602; Cecconi L; Busi Rizzi E; Schinina V; Mazzuoli G; Timpano C; Servizio di Radiologia, IRCCS Ospedale Lazzaro Spallanzani, Roma.
[Lung tuberculosis in HIV positive patients. Clinico-radiologic correlations]: Radiol Med (Torino). 1997 May;93(5):527-31. Unique Identifier : AIDSLINE MED/97395607; Diotallevi P; Cristofaro M; Montella F; Scano M; Geraci S; Simili C; Azienda Ospedaliera San Giovanni-Addolorata, Roma.; We investigated the radiologic features of pulmonary tuberculosis in HIV+ patients. SUBJECTS AND METHODS: 24 cases of pulmonary tuberculosis in HIV+ patients were studied (17 men and 7 women, average age: 38 years). The study includes 19 drug addicts, 3 homosexuals, 1 polytransfused subject and 1 patient not belonging
[Diagnostic imaging and therapeutic implications in lung infections in patients with HIV-1 infection]: Radiol Med (Torino). 1997 May;93(5):532-8. Unique Identifier : AIDSLINE MED/97395608; Carella E; Moschini GL; Romanelli F; Bossalini G; Alberici F; Viale P; Ratti G; Servizio di Radiologia, Ospedale Civile, Piacenza.; We studied retrospectively 132 episodes of infectious pneumonias in 89 patients examined from 1990 to 1995. Pneumocystis carinii was found to be the most common cause of pneumonia (33 patients). The other causes were: Streptococcus pneumoniae (15), Mycobacterium tuberculosis (14), Pseudomonas aeruginosa (8), Staphyloc
[Description of an unusual case of hepatic leishmaniasis in AIDS]: Radiol Med (Torino). 1997 May;93(5):644-5. Unique Identifier : AIDSLINE MED/97395636; Boscia D; Lamacchia M; Radiologia Ospedaliera, Azienda Policlinico, Bari.
[Cholangitis with hepatosplenomegaly caused by Xanthomonas maltophilia in a patient with AIDS (letter)]: Rev Clin Esp. 1997 May;197(5):382-3. Unique Identifier : AIDSLINE MED/97406101; Ortiz Cansado A; Morales Blanco PJ; Arrobas Vaca I; Lopez Cupido V
[Polycythemia in a patient with HIV (letter)]: Rev Clin Esp. 1997 May;197(5):383-4. Unique Identifier : AIDSLINE MED/97406102; Caminal Montero L; Trapiella Martinez L; Gonzalez Marroquin A; Fernandez Fernandez C; Sanz Rubiales A
[HIV infection. Epidemiology, screening, prevention, main immunological abnormalities, prognostic biological markers, classification (evolutive staging)]: Rev Prat. 1997 Jun 15;47(12):1347-55. Unique Identifier : AIDSLINE MED/97391295; Raffi PF; Maladies infectieuses et tropicales, Hotel-Dieu, Nantes.
Telomerase activity of reverse transcriptase [letter; comment]: Science. 1997 Aug 15;277(5328):887. Unique Identifier : AIDSLINE MED/97420338; Ricchetti M; Buc H
Migrancy, masculine identities and AIDS: the psychosocial context of HIV transmission on the South African gold mines.: Soc Sci Med. 1997 Jul;45(2):273-81. Unique Identifier : AIDSLINE MED/97368800; Campbell C; London School of Economics and Political Science, U.K.; Levels of HIV infection are particularly high amongst migrant workers in sub-Saharan Africa. This paper presents a case study of one such vulnerable group of migrants-underground workers on the South African gold mines-and highlights the psychosocial context of HIV transmission in the mining setting. On the assumption
Communicating with the people about HIV infection risk as a basis for planning interventions: lessons from the Kagera Region of Tanzania.: Soc Sci Med. 1997 Jul;45(2):319-29. Unique Identifier : AIDSLINE MED/97368804; Killewo J; Sandstrom A; Dahlgren L; Wall S; Department of Epidemiology and Biostatistics, Muhimbili University; College of Health Sciences, Dar es Salaam, Tanzama.; In order to deepen the understanding of risk factors associated with HIV infection in the Kagera region of Tanzania and to investigate the potentials of communicating with the people in planning for interventions, two studies were performed in the districts of Bukoba Urban, Bukob
The increasing burden of tuberculosis in rural South Africa--impact of the HIV epidemic [see comments]: S Afr Med J. 1997 Apr;87(4):447-50. Unique Identifier : AIDSLINE MED/97398574; Wilkinson D; Davies GR; Centre for Epidemiological Research in Southern Africa, South African; Medical Research Council, Hlabisa, KwaZulu-Natal.; OBJECTIVE: To determine the impact of the HIV epidemic on tuberculosis caseload in rural South Africa . SETTING: Hlabisa health district, KwaZulu-Natal. METHODS: Demographic and clinical data were extracted from the tuberculosis database for the period, May 1991-June 1995. The attr
Virodene--support misguided [letter]: S Afr Med J. 1997 Apr;87(4):466. Unique Identifier : AIDSLINE MED/97398579; Folb PI; van Gelder A; Swan GE
Interferon found helpful in herpes genitalis case [letter]: S Afr Med J. 1997 Apr;87(4):475. Unique Identifier : AIDSLINE MED/97398590; Dungwa N
Induction of T helper 2 immunity to an immunodominant allopeptide.: Transplantation. 1997 Jul 27;64(2):292-6. Unique Identifier : AIDSLINE MED/97398265; Lehmann PV; Matesic D; Benichou G; Heeger PS; Department of Pathology, Case Western Reserve University, Cleveland,; Ohio, USA.; Neonatal tolerance to alloantigens and autoantigens in mice is mediated by T helper (Th)2 immunity. If a strong and pure Th2 response could be engaged to alloantigens in adult mice, it might result in allograft tolerance. In an attempt to induce Th2 immunity in adults, we studied the T-cell response to peptide I-A bet
CD4+ T cells are able to reject class I disparate allografts.: Transplantation. 1997 Jul 27;64(2):335-40. Unique Identifier : AIDSLINE MED/97398272; Sawada T; Wu Y; Sachs DH; Iacomini J; Transplantation Biology Research Center, Massachusetts General; Hospital, and Harvard Medical School, Boston 02129, USA.; The ability of CD4+ T cells to reject class I mismatched skin allografts remains controversial. In this study, we compare the ability of CD4+ T cells to reject class I disparate skin grafts differing by either a single class I allelic disparity or only 3 amino acids encoded by the H-2K locus. We demonstrate that skin
Recognition of porcine major histocompatibility complex class I antigens by human CD8+ cytolytic T cell clones.: Transplantation. 1997 Jul 27;64(2):340-6. Unique Identifier : AIDSLINE MED/97398273; Shishido S; Naziruddin B; Howard T; Mohanakumar T; Department of Surgery, Washington University School of Medicine, St.; Louis, Missouri 63110, USA.; To evaluate the nature of the human cellular immune response to porcine xenoantigens, cytolytic T lymphocyte (CTL) cell lines were generated against porcine aortic endothelial cells (PAEC). After four stimulations, the phenotypes of the T cell lines were primarily CD8+ (79.7+/-19.6%). Natural killer cells were not det
Immunophenotypic analysis of foal bronchoalveolar lavage lymphocytes.: Vet Microbiol. 1997 Jun 16;56(3-4):237-46. Unique Identifier : AIDSLINE MED/97370516; Balson GA; Smith GD; Yager JA; Department of Pathobiology, University of Guelph, Ont., Canada.; The purpose of this study was to define the normal immunophenotype of equine lymphocytes present within the pulmonary air spaces, and to determine if this changes as foals age from one to ten weeks. Six pairs of mares and foals underwent sequential bronchoalveolar lavage (BAL) between 1 and 10 weeks of age. Data were
[Leprosy and infection by the human immunodeficiency virus (HIV) editorial)]: Acta Leprol. 1997;10(3):129-30. Unique Identifier : AIDSLINE MED/97406432; Flageul B
Prevalence of HIV1 in leprosy patients in Rio de Janeiro, Brazil.: Acta Leprol. 1997;10(3):159-63. Unique Identifier : AIDSLINE MED/97406437; Andrade VL; Moreira Alves T; Regazzi Avelleira JC; Bayona M; State Institute of Sanitary Dermatology, Rio de Janeiro-Brazil/CNPQ-,; Brazil. vandrade@ism.com.br; The purpose of this study was to learn if HIV1 infection was associated with leprosy in Rio de Janeiro, Brazil by comparing the prevalence rates of 1.016 leprosy patients tested on a voluntary basis and 78.482 blood donors. A cross-sectional survey of anti-HIV1 antibodies was condu
Expression of RT6 on activated rat T cells.: Adv Exp Med Biol. 1997;419:257-64. Unique Identifier : AIDSLINE MED/97336916; Wonigeit K; Klinik Fur Abdominal- Und Transplantationschirurgie, Medizinische; Hochschule Hannover, Germany.; The gene products of the RT6 system have been demonstrated to be expressed on the majority of resting peripheral T cells but not on fully activated cytotoxic T cells and in vitro generated long term T cell lines. This has lead to the conclusion that T cell activation causes a loss of RT6 expression. In the present stu
Role of cellular immunity in protection against HIV infection.: Adv Immunol. 1997;65:277-346. Unique Identifier : AIDSLINE MED/97381156; Rowland-Jones S; Tan R; McMichael A; Institute of Molecular Medicine, John Radcliffe Hospital, Headington,; Oxford, United Kingdom.
Xerostomia: a symptom which acts like a disease [letter; comment]: Age Ageing. 1997 May;26(3):239. Unique Identifier : AIDSLINE MED/97366912; Harry TC
Invasive aspergillosis of the paranasal sinuses and orbit: can you save the eye?: Am J Otolaryngol. 1997 Jul-Aug;18(4):230-4. Unique Identifier : AIDSLINE MED/97386782; Adler SC; Isaacson G; Sasaki CT; Department of Otolaryngology/Head and Neck Surgery, Temple University; Hospital, Philadelphia, PA, USA.
Sequencing of N-linked oligosaccharides directly from protein gels: in-gel deglycosylation followed by matrix-assisted laser desorption/ionization mass spectrometry and normal-phase high-performance liquid chromatography.: Anal Biochem. 1997 Jul 15;250(1):82-101. Unique Identifier : AIDSLINE MED/97378221; Kuster B; Wheeler SF; Hunter AP; Dwek RA; Harvey DJ; Department of Biochemistry, Oxford Glycobiology Institute, University; of Oxford, United Kingdom.; A generally applicable, rapid, and sensitive method for profiling and sequencing of glycoprotein-associated N-linked oligosaccharides from protein gels was developed. The method employed sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) for protein separation and purification and in-gel deglycosylat
[Prevention of tuberculosis in immunocompromised patients]: Ann Med Interne (Paris). 1997;148(3):226-9. Unique Identifier : AIDSLINE MED/97399201; Perronne C; Service des Maladies Infectieuses et Tropicales, Hopital; Raymond-Poincare, Garches.; Immunosuppressed patients have an increased risk of developing active tuberculosis, either by reactivation of an old infection, or by horizontal acquisition during a contact with a contagious tuberculous patient. The diagnosis of tuberculosis requires a clinical examination and the realization of a PPD skin test and a
[Prevention of atypical mycobacterium infections in immunocompromised patients]: Ann Med Interne (Paris). 1997;148(3):230-4. Unique Identifier : AIDSLINE MED/97399202; Meynard JL; Service de Medecine Interne, Centre Hospitalier Intercommunal,; Creteil.; Unusual before AIDS epidemic, non tuberculosis mycobacterial infections were observed in HIV-infected patients with CD4 cells count less than 75/mm3. Primary prophylaxis with rifabutin, clarithromycin or azythromycin may be used. Secondary prophylaxis are necessary with association of two or three drugs among clarithr
[Prevention of toxoplasmosis in immunocompromised patients]: Ann Med Interne (Paris). 1997;148(3):235-9. Unique Identifier : AIDSLINE MED/97399203; Morlat P; Leport C; Service de Medecine Interne, Hopital Saint-Andre, Bordeaux.; The main underlying immunosuppressive conditions requiring prevention of toxoplasmosis are organ transplantations especially heart and bone marrow transplants) and advanced HIV infection (CD4 + lymphocytes count
[Prevention of parasitic infections (excluding toxoplasmosis) in immunocompromised patients]: Ann Med Interne (Paris). 1997;148(3):240-5. Unique Identifier : AIDSLINE MED/97399204; Hennequin C; Service de Microbiologie, Hopital Necker, Paris.; Immunocompromised patients, notably those with cell mediated immunity deficiency, are at risk for severe and life-threatening parasitic infections. Severity and frequency of Pneumocystis carinii pneumonia have led to systematically initiate prophylaxis for high-risk patients such as patients with HIV infection, hemopa
[Primary and secondary prevention of cytomegalovirus infections in immunocompromised patients]: Ann Med Interne (Paris). 1997;148(3):246-54. Unique Identifier : AIDSLINE MED/97399205; Salmon-Ceron D; Service de Medecine Interne 2, Hopital Cochin, Paris.; Seroprevalence for CMV varies from 70% in the general population to more than 90% in HIV infected patients. Immunodepression whatever its origin, either post therapeutic as in transplant recipients, or induced by HIV, leads to the reactivation of this virus, pre
[Prevention of herpes simplex and varicella zoster infections in patients of HIV infections]: Ann Med Interne (Paris). 1997;148(3):255-7. Unique Identifier : AIDSLINE MED/97399206; Caumes E; Bricaire F; Service de Maladies Infectieuses et Tropicales, GH Pitie-Salpetriere,; Paris.; Reactivation of Herpes simplex virus and varicella zoster virus infections occurs frequently in patients infected with human immunodeficiency virus (HIV). Prevention of Herpes simplex recurrences with oral acyclovir (400 mg x 2/day) should be recommended for patients with more t
[Prevention of infections in immunosuppressed patients: prevention of post-transfusion infections]: Ann Med Interne (Paris). 1997;148(3):268-71. Unique Identifier : AIDSLINE MED/97399208; Joly V; Service de Medecine Interne, Hopital Bichat-Claude-Bernard, Paris.; CMV infection is the most severe transfusion-transmitted infection in immunosuppressed patients, and must be prevented in high-risk subjects by the use of seronegative units or by the use if leucocyte-reduced units. The value of these methods has been shown in p
[Vaccinations in immunosuppressed patients]: Ann Med Interne (Paris). 1997;148(3):272-9. Unique Identifier : AIDSLINE MED/97399209; Bouchaud O; Service des Maladies Infectieuses et Tropicales, Hopital Bichat-Claude; Bernard, Paris.; In immune deficiency of any cause, immunization is of great interest to avoid preventable infectious diseases but the risk of adverse events and suboptimal immunologic responses has to be considered. For live, attenuated vaccines, the main risks are post-immunization complications, especially in severely immunocomprom
Infection control and contaminated waste disposal practices in Southern Sydney Area Health Service Dental Clinics.: Aust Dent J. 1997 Jun;42(3):199-202. Unique Identifier : AIDSLINE MED/97385919; Cannata S; Bek M; Baker P; Fett M; Southern Sydney Public Health Unit.; The sterilization and contaminated waste disposal practices in all 14 dental clinics operated by the Southern Sydney Area Health Service were surveyed. All of the clinics used autoclaves for sterilization. All hand instruments, handpieces and triplex syringes were autoclaved between patients. Chemical disinfection sol
Needle exchange is not enough: lessons from the Vancouver injecting drug use study.: AIDS. 1997 Jul;11(8):F59-65. Unique Identifier : AIDSLINE MED/97366914; Strathdee SA; Patrick DM; Currie SL; Cornelisse PG; Rekart ML; Montaner JS; Schechter MT; O'Shaughnessy MV; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To describe prevalence and incidence of HIV-1, hepatitis C virus (HCV) and risk behaviours in a prospective cohort of injecting drugs users (IDU). SETTING: Vancouver, which introduced a needle exchange programme (NEP) in 1988, and currently exchanges over 2 million needles per year. DESIGN: IDU who had inje
Longer survival after HIV infection for injecting drug users than for homosexual men: implications for immunology.: AIDS. 1997 Jul;11(8):1007-12. Unique Identifier : AIDSLINE MED/97366922; Pehrson P; Lindback S; Lidman C; Gaines H; Giesecke J; Karolinska Institute Department of Infectious Disease, Huddinge; University Hospital, Stockholm, Sweden.; BACKGROUND: Comparisons of progression in HIV-1 infection between injecting drug users (IDU) and homosexual men have been inconclusive due to the short follow-up periods, often with less well-defined starting points and endpoints. In addition, comparisons of survival after injection have been to some extent obscured b
Immunologic and virologic evaluation after influenza vaccination of HIV-1-infected patients.: AIDS. 1997 Jul;11(8):1013-21. Unique Identifier : AIDSLINE MED/97366923; Fowke KR; D'Amico R; Chernoff DN; Pottage JC Jr; Benson CA; Sha BE; Kessler HA; Landay AL; Shearer GM; Experimental Immunology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; OBJECTIVE: The present study was designed to determine the effect of immune activation, achieved by influenza vaccination, on plasma HIV RNA levels and immunological parameters including CD4 cell levels, antigen-stimulated T-cell function and apoptotic death of peripheral blood mononuclear cells. DESIGN AND METHODS: T
Trends in HIV-1 prevalence may not reflect trends in incidence in mature epidemics: data from the Rakai population-based cohort, Uganda.: AIDS. 1997 Jul;11(8):1023-30. Unique Identifier : AIDSLINE MED/97366924; Wawer MJ; Serwadda D; Gray RH; Sewankambo NK; Li C; Nalugoda F; Lutalo T; Konde-Lule JK; Center for Population and Family Health, Columbia University School of; Public Health, New York, USA.; OBJECTIVES: To assess whether trends in serial HIV-1 prevalence reflect trend in HIV incidence, and to decompose the effects of HIV-1 incidence, mortality, mobility and compliance on HIV-1 prevalence in a population-based cohort. DESIGN: Two-year follow up (1990-1992) of an open cohort of all adults aged 15-59 years,
How many HIV infections cross the bisexual bridge? An estimate from the United States.: AIDS. 1997 Jul;11(8):1031-7. Unique Identifier : AIDSLINE MED/97366925; Kahn JG; Gurvey J; Pollack LM; Binson D; Catania JA; Center for AIDS Prevention Studies, University of California, San; Francisco (UCSF), USA.; OBJECTIVE: Most heterosexual women with AIDS have been infected by male sex partners who acquired HIV via injecting drug use or sex with men. The contribution of bisexuality to heterosexual HIV however, has been poorly quantified. In this paper, we estimate the number of HIV infections that spread from the homosexual
On-site, rapid HIV testing with same-day results and counseling.: AIDS. 1997 Jul;11(8):1045-51. Unique Identifier : AIDSLINE MED/97366927; Kassler WJ; Dillon BA; Haley C; Jones WK; Goldman A; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; BACKGROUND: New rapid HIV antibody tests have allowed provision of results and result-specific counseling on the day on initial visit, and have the potential to increase the efficiency of HIV counseling and testing. METHODS: To evaluate the use of rapid testing with same-day results in public clinics, the Single Use D
Does HIV-2 infection provide cross-protection against HIV-1 infection? [letter]: AIDS. 1997 Jul;11(8):1053-4. Unique Identifier : AIDSLINE MED/97366928; Ariyoshi K; Schim van der Loeff M; Sabally S; Cham F; Corrah T; Whittle H
Changes in plasma HIV RNA levels and CD4 cell counts after vaccination of pediatric patients [letter]: AIDS. 1997 Jul;11(8):1054-6. Unique Identifier : AIDSLINE MED/97366929; Donovan RM; Moore E; Bush CE; Markowitz NP; Saravolatz LD
Quantification of HIV-1 RNA in cervicovaginal secretions: an improved method of sample collection [letter]: AIDS. 1997 Jul;11(8):1056-8. Unique Identifier : AIDSLINE MED/97366930; O'Shea S; de Ruiter A; Mullen J; Corbett K; Chrystie I; Newell ML; Banatvala JE
HIV-1 viral load in blood, semen and saliva [letter; comment]: AIDS. 1997 Jul;11(8):1058-9. Unique Identifier : AIDSLINE MED/97432959; Vernazza PL; Dyer JR; Fiscus SA; Eron JJ; Cohen MS
Detection of apoptotic cells from peripheral blood of HIV-infected individuals using a novel monoclonal antibody [letter]: AIDS. 1997 Jul;11(8):1059-61. Unique Identifier : AIDSLINE MED/97366931; Seth A; Zhang C; Letvin NL; Schlossman SF
The production of beta-chemokines induced by HIV-2 envelope glycoprotein [letter]: AIDS. 1997 Jul;11(8):1062-3. Unique Identifier : AIDSLINE MED/97366932; Neoh LP; Akimoto H; Kaneko H; Hishikawa T; Hashimoto H; Hirose S; Kaneko Y; Yamamoto N; Sekigawa I
Baclofen for treatment of persistent hiccups in HIV-infected patients [letter]: AIDS. 1997 Jul;11(8):1063-4. Unique Identifier : AIDSLINE MED/97366933; D'Alessandro DJ; Dever LL
Condoms used during most commercial sex acts in Thailand [letter]: AIDS. 1997 Jul;11(8):1064-5. Unique Identifier : AIDSLINE MED/97366934; Robinson NJ; Hanenberg R
Epidemiology of Mycobacterium avium infection in northern Italy [letter]: AIDS. 1997 Jul;11(8):1065-6. Unique Identifier : AIDSLINE MED/97366935; Franzetti F; Gori A; Vezzoli S; Rossi C; Degli Esposti A; Bandera A; Nardi G; Rusconi S
Oral methionine may improve neuropsychological function in patients with AIDS myelopathy: results of an open-label trial [letter]: AIDS. 1997 Jul;11(8):1066-7. Unique Identifier : AIDSLINE MED/97366936; Dorfman D; DiRocco A; Simpson D; Tagliati M; Tanners L; Moise J
Effects of indinavir treatment on platelet and neutrophil counts in patients with advanced HIV disease [letter]: AIDS. 1997 Jul;11(8):1067-8. Unique Identifier : AIDSLINE MED/97366937; Tozzi V; Narcisco P; Sebastiani G; Frigiotti D; D'Amato C
Foscarnet-induced hypercalcaemia in AIDS [letter]: AIDS. 1997 Jul;11(8):1068-70. Unique Identifier : AIDSLINE MED/97366938; Gayet S; Ville E; Durand JM; Mars ME; Morange S; Kaplanski G; Gallais H; Soubeyrand J
Role of trimethoprim-sulphamethoxazole in preventing HIV-associated bacteraemia [letter; comment]: AIDS. 1997 Jul;11(8):1070-1. Unique Identifier : AIDSLINE MED/97366939; Tumbarello M; Tacconelli E; Cauda R; Ortona L
Gender difference in CD4+ cell counts persist after HIV-1 infection. SEROCO Study Group [letter]: AIDS. 1997 Jul;11(8):1071-3. Unique Identifier : AIDSLINE MED/97366940; Delmas MC; Jadand C; De Vincenzi I; Deveau C; Persoz A; Sobel A; Kazatchkine M; Brunet JB; Meyer L
Absence of detectable maternal DNA and identification of proviral HIV in the cord blood of two infants who became HIV-infected [letter] [corrected and republished with original paging, letter originally printed in AIDS 1997 May;11(6):840-1]: AIDS. 1997 Jul;11(8):840-1. Unique Identifier : AIDSLINE MED/97366941; De Andreis C; Simoni G; Castagna C; Sacchi L; Sirchia SM; Garagiola I; Persico T; Serafini P; Pardi G; Semprini AE
Two parallel routes of the complement-mediated antibody-dependent enhancement of HIV-1 infection.: AIDS. 1997 Jul;11(8):949-58. Unique Identifier : AIDSLINE MED/97366915; Prohaszka Z; Nemes J; Hidvegi T; Toth FD; Kerekes K; Erdei A; Szabo J; Ujhelyi E; Thielens N; Dierich MP; Spath P; Ghebrehiwet B; Hampl H; Kiss J; Arlaud G; Fust G; National Institute of Haematology, Blood Transfusion and Immunology,; Budapest, Hungary.; OBJECTIVE: To study the mechanism of the complement-mediated antibody-dependent enhancement (C -ADE) of HIV infection which may play a significant role in the progression of HIV-disease. METHODS: In vitro complement activating and complement-mediated HIV-infection enhancing abilities of three human anti-gp41 monoclona
Characteristics of the CD8+ lymphocytosis during primary simian immunodeficiency virus infections.: AIDS. 1997 Jul;11(8):959-68. Unique Identifier : AIDSLINE MED/97366916; Rosenberg YJ; Cafaro A; Brennan T; Greenhouse JG; McKinnon K; Bellah S; Yalley-Ogunro J; Gartner S; Lewis MG; TherImmune Inc., Rockville, Maryland, USA.; OBJECTIVE: To investigate the source of the expanded blood CD8+ subsets during an acute primary simian immunodeficiency virus SIV) infection of macaques and the potential role of these cells in disease progression. DESIGN AND METHODS: The primary CD8+ lymphocytosis, which occurs at 1-2 weeks following infection with S
Correlation between susceptibility of primary HIV-1 isolates to autologous and heterologous neutralizing antibodies. Hospital Evandro Chagas AIDS Clinical Research Group.: AIDS. 1997 Jul;11(8):969-75. Unique Identifier : AIDSLINE MED/97366917; Bongertz V; Costa CI; Santos VG; Joao Filho EC; Galvao-Castro B; Morgado MG; Department of Immunology, IOC/FIOCRUZ, Rio de Janeiro, Brazil.; OBJECTIVE: To study the susceptibility of primary HIV-1 isolates towards autologous and heterologous neutralizing antibodies NAb). DESIGN: Blood was collected and primary HIV-1 isolated from individuals residing in Rio de Janeiro, Brazil , in all phases of disease. METHODS: Primary
Experimental gene therapy: the transfer of Tat-inducible interferon genes protects human cells against HIV-1 challenge in vitro and in vivo in severe combined immunodeficient mice.: AIDS. 1997 Jul;11(8):977-86. Unique Identifier : AIDSLINE MED/97366918; Sanhadji K; Leissner P; Firouzi R; Pelloquin F; Kehrli L; Marigliano M; Calenda V; Ottmann M; Tardy JC; Mehtali M; Touraine JL; Laboratory of Immune Deficiency and INSERM U80, Department of Medicine; R.T.H. Laennec, Lyon, France.; OBJECTIVES: To evaluate in vitro and in vivo a strategy for gene therapy for AIDS based on the transfer on interferon (IFN)-alpha, beta and -gamma genes to human cells. DESIGN: Human U937 promonocytic cells were stably transfected with Tat-inducible IFN expression vectors conferring an antiviral state against infectio
Quantification of HIV in semen: correlation with antiviral treatment and immune status.: AIDS. 1997 Jul;11(8):987-93. Unique Identifier : AIDSLINE MED/97366919; Vernazza PL; Gilliam BL; Dyer J; Fiscus SA; Eron JJ; Frank AC; Cohen MS; Institute for Clinical Microbiology and Immunology, Kantonsspital, St; Gallen, Switzerland.; OBJECTIVE: This study examined the concentration of HIV in semen and the effects of biological factors on HIV excretion. METHODS: Semen samples from 101 men at different stages of the disease were evaluated by quantitative HIV culture and HIV RNA detection. Blood plasma samples were available from 56 patients. The eff
Frequency and risk factors of infectious complications in neutropenic patients infected with HIV.: AIDS. 1997 Jul;11(8):995-8. Unique Identifier : AIDSLINE MED/97366920; Meynard JL; Guiguet M; Arsac S; Frottier J; Meyohas MC; Service des Maladies Infectieuses et Tropicales, Hopital; Saint-Antoine, Paris, France.; OBJECTIVE: To determine causes, incidence and factors associated with infections in neutropenic [polymorphonuclear neutrophil PMN), 1000 x 10(6)/l] HIV-infected patients. DESIGN: Prospective study. SETTING: Infectious disease service of a 1000-bed university teaching hospital in Paris,
Impact of treatment changes on the interpretation of the Concorde trial.: AIDS. 1997 Jul;11(8):999-1006. Unique Identifier : AIDSLINE MED/97366921; White IR; Walker S; Babiker AG; Darbyshire JH; Department of Epidemiology and Population Sciences, London School of; Hygiene and Tropical Medicine, UK.; BACKGROUND: The Concorde trial compared two policies of therapy with zidovudine (ZVD) in individuals with asymptomatic HIV infection: immediate or deferred ZDV. Participants in both groups could stop their blinded trial therapy for several reasons and/or could start open-label ZDV. The difference in survival and disea
Campaign for health care worker safety.: Asepsis. 1996 3rd Quarter;18(3):14-7. Unique Identifier : AIDSLINE MED/97417885; Arnold LM
XI International Conference on AIDS. HIV update 1996: notes from Vancouver.: Asepsis. 1996 3rd Quarter;18(3):19-23. Unique Identifier : AIDSLINE MED/97417886; Klimek JJ; Department of Medicine, Hartford Hospital, Connecticut, USA.
Differential regulation of human, antigen-specific Th1 and Th2 responses by the B-7 homologues, CD80 and CD86.: Am J Respir Cell Mol Biol. 1997 Aug;17(2):235-42. Unique Identifier : AIDSLINE MED/97415513; Bashian GG; Braun CM; Huang SK; Kagey-Sobotka A; Lichtenstein LM; Essayan DM; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, Maryland, USA.; A selectivity of B7.1 (CD80) for promoting Th1 responses and B7.2 CD86) for promoting Th2 responses in the murine system has recently been suggested. The present study explores this hypothesis, using human PBMCs and antigen-specific Th1 and Th2 clones. Proliferative responses of peripheral blood mononuclear cells (PBM
Antiretroviral therapy in adults.: J Am Acad Nurse Pract. 1996 Jul;8(7):329-41. Unique Identifier : AIDSLINE MED/97426854; Wise B; College of Nursing and Health, Wright State University, Dayton, OH,; USA.
Nurse activism could stop AIDS pandemic [news]: Nurs Stand. 1997 Jun 25;11(40):9. Unique Identifier : AIDSLINE MED/97423230
Involvement of the bcl-6 gene in AIDS-related lymphomas.: Ann Oncol. 1997;8 Suppl 2:105-8. Unique Identifier : AIDSLINE MED/97353403; Gaidano G; Pastore C; Capello D; Migliazza A; Gloghini A; Saglio G; Carbone A; Dalla-Favera R; Dipartimento di Scienze Mediche, Universita di Torino, Novara, Italy.; BACKGROUND: Non-Hodgkin s lymphoma (NHL) represents a major complication of AIDS. Systemic AIDS-related NHLs (AIDS-NHLs) derive from B cells and are classified into four distinct groups, including small noncleaved-cell lymphoma (SNCCL), diffuse large-cell lymphoma (DLCL), anaplastic large-cell lymphoma ALCL), and body
Characteristics of human EBV-specific cytotoxic T lymphocytes utilized for adoptive immunotherapy of EBV-induced lymphoproliferations in xenografted SCID mice.: Ann Oncol. 1997;8 Suppl 2:137-40. Unique Identifier : AIDSLINE MED/97353408; Lacerda JF; O'Reilly RJ; Bone Marrow Transplantation Service, Memorial Sloan-Kettering Cancer; Center, New York, USA.; Human Epstein-Barr virus-specific cytotoxic T lymphocytes EBV-CTLs) prolong the survival of mice with severe combined immune deficiency bearing the autologous, but not HLA-mismatched, human EBV-induced lymphoproliferative disorders (EBV-LPDs). In the present study, we demonstrate that the HLA-restricted activity displ
Are CD8+ dendritic cells (DC) veto cells? The role of CD8 on DC in DC development and in the regulation of CD4 and CD8 T cell responses.: Int Immunol. 1997 Jul;9(7):1061-4. Unique Identifier : AIDSLINE MED/97380325; Kronin V; Vremec D; Winkel K; Classon BJ; Miller RG; Mak TW; Shortman K; Suss G; Walter and Eliza Hall Institute of Medical Research, Melbourne,; Victoria, Australia.; The CD8-expressing dendritic cells (DC) present in mouse spleen have been shown to have a regulatory effect on the CD4 and CD8 T cells they activate, restricting subsequent T cell proliferation by either inducing apoptotic T cell death (CD4 T cells) or by limiting endogenous cytokine production (CD8 T cells). To deter
Characterization of rat CD80 and CD86 by molecular cloning and mAb.: Int Immunol. 1997 Jul;9(7):993-1000. Unique Identifier : AIDSLINE MED/97380318; Maeda K; Sato T; Azuma M; Yagita H; Okumura K; Department of Immunology, Juntendo University School of Medicine,; Tokyo, Japan.; The CD28/B7 pathway provides a critical co-stimulatory signal for T cell activation. In the present study, we cloned rat CD80 and CD86 cDNA from a HTLV-1-transformed rat T cell line, Lewis-S1, expressing a high level of CTLA-4-Ig binding proteins. The predicted CD80 and CD86 polypeptides were composed of 321 and 313 a
Measurement of reverse transcriptase of feline immunodeficiency virus by poly A-linked colorimetric assay.: J Vet Med Sci. 1997 Jun;59(6):425-9. Unique Identifier : AIDSLINE MED/97378610; Saito T; Suzuki K; Imai M; Inaba Y; Department of Virology, Kanagawa Prefectural Public Health Laboratory,; Yokohama, Japan.; The method of the poly A-linked colorimetric reverse transcriptase assay (PAC-RTA) was developed and evaluated for the measurement of Mg(2+)-dependent reverse transcriptase (RT) activity of feline immunodeficiency virus (FIV). PAC-RTA was first evaluated for the detection of RT activity in the culture supernatant of F
Homeostasis of chemokines, interferon production and lymphocyte subsets: implications for AIDS pathogenesis.: Biomed Pharmacother. 1997;51(5):221-9. Unique Identifier : AIDSLINE MED/97389968; Cho YY; Astgen A; Hendel H; Issing W; Perrot JY; Schachter F; Rappaport J; Zagury JF; Laboratoire de Physiologie Cellulaire, Universite Pierre et Marie; Curie, Paris, France.; Certain individuals with elevated levels of macrophage inflammatory protein (MIP)1 alpha, MIP1 beta and RANTES expression appear to be resistant to human immunodeficiency virus HIV) infection. In this work, we demonstrate that chemokines production by peripheral blood mononuclear cells (PBMCs) are homeostatic paramete
Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines.: Anticancer Drugs. 1997 Jun;8(5):470-81. Unique Identifier : AIDSLINE MED/97358515; Mehta K; Pantazis P; McQueen T; Aggarwal BB; Department of Bioimmunotherapy, The University of Texas MD Anderson; Cancer Center, Houston 77030, USA.; Pharmacologically safe compounds that can inhibit the proliferation of tumor cells have potential as anticancer agents. Curcumin, a diferuloylmethane, is a major active component of the food flavor turmeric (Curcuma longa) that exhibits anticarcinogenic properties in vivo. In vitro, it suppressed c-jun/Ap-1 and NF-kap
Guidelines regarding HIV and other bloodborne pathogens in vascular/interventional radiology. SCVIR Technology Assessment Committee.: J Vasc Interv Radiol. 1997 Jul-Aug;8(4):667-76. Unique Identifier : AIDSLINE MED/97376477; Hansen ME; Bakal CW; Dixon GD; Eschelman DJ; Horton KM; Katz M; Olcott EW; Sacks D; SCVIR, Fairfax, VA 22030, USA.
Modulation of protective and pathological immunity in mycobacterial infections.: Int Arch Allergy Immunol. 1997 Aug;113(4):400-8. Unique Identifier : AIDSLINE MED/97392353; Ottenhoff TH; Spierings E; Nibbering PH; de Jong R; Department of Immunohematology and Blood Bank, University Hospital,; Leiden, The Netherlands. ihbsecr@euronet.nl; Mycobacterial infections represent major problems to global health care. Tuberculosis is feared particularly because of its high mortality rates whereas in leprosy the occurrence of immunopathology, particularly nerve damage, is a major problem since the bacillus itself is relatively harmless. Thus, both effective vac
[Pulmonary complications during HIV infection in children]: Pneumoftiziologia. 1997 Jan-Mar;46(1):39-44. Unique Identifier : AIDSLINE MED/97395292; Murgoci G; Anastasatu O; Institutul de Pneumoftiziologie Marius Nasta.
[Acquired recto-vaginal fistula in children: is HIV infection a cause?]: Bull Soc Pathol Exot. 1997;90(2):111-2. Unique Identifier : AIDSLINE MED/97406592; Bankole Sanni R; Denoulet C; Coulibaly B; Mobiot ML; Anglaret X; Sylla-Koko F; Chirurgie pediatrique, CHU de Treichville, Abidjan, Cote d'Ivoire.; Seven successive cases of acquired rectovaginal fistula have been diagnosed on children of three and half to eighteen months old. These fistula were localised on the fourchette. The seropositivity for HIV of five cases confirmed the results of similar reports found in literature. Surgical treatment of these girls was
[Dehydration: an important factor of mortality in human immunodeficiency virus (HIV) seropositive malnourished children]: Bull Soc Pathol Exot. 1997;90(2):71-3. Unique Identifier : AIDSLINE MED/97406581; Beau JP; Imboua-Coulibaly L; ORSTOM, Cote-d'Ivoire.; A combination of diarrhoea and malnutrition frequently occurs in HIV seropositive children and constitutes a bad prognosis factor. The impact of dehydration induced by diarrhoea in these children has not as yet been assessed and constitutes the aim of this study. This retrospective analysis was conducted on 121 malnou
[Detection of hepatitis c in blood donors in Niamey]: Bull Soc Pathol Exot. 1997;90(2):74. Unique Identifier : AIDSLINE MED/97406582; Mamadou S; Gragnic G; Kabo R; Salami H; Boulkassoum Z; Faculte des sciences de la sante, Niamey, Niger.; We searched for HCV antibodies in a random sample of 410 blood donors negative for HIV infection, hepatitis B and syphilis. 16 peoples were positive by ELISA and 13 by RIBA. So 3.2% of these donors negative for the three actual compulsory tests, are able to transmit HCV.
[Chancroid in Algeria: the status of this sexually transmitted disease in 1995]: Bull Soc Pathol Exot. 1997;90(2):78-80. Unique Identifier : AIDSLINE MED/97406584; Boudghene-Stambouli O; Merad-Boudia A; Service de dermato-venereologie, Centre hospitalo-universitaire de; Tlemcen, Algerie.; Absent for several decades, the chancroid reappeared in Algeria in 1988. In the unique department of Dermatology and Venereology of the University Hospital of the country of Tlemcen (more than 700,000 inhabitants), we wanted to know the state of this STD seven years after the repo
Anticipated outcomes of accidental occupational exposure to HIV.: Clin Nurs Res. 1997 Aug;6(3):291-9. Unique Identifier : AIDSLINE MED/97426808; Meisenhelder JB; MGH Institute of Health Professions.; This descriptive study surveyed a random sample of 60 registered nurses (R.N.s) regarding their perceptions of nine possible consequences of an HIV infection resulting from occupational exposure. Areas of highest concern were financial: adequacy of workers compensation and ability of the employer to cover all health
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Jul 25;7(30):271-4. Unique Identifier : AIDSLINE MED/97412301
Pulmonary fungal infections in immunocompromised children.: Curr Opin Pediatr. 1997 Jun;9(3):213-8. Unique Identifier : AIDSLINE MED/97373105; Shenep JL; Flynn PM; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, TN 38105-2794, USA.; Pulmonary mycoses are increasingly encountered in children with underlying diseases associated with immunosuppression, including children with cancer or HIV infection. Knowledge of the epidemiology and pathogenesis of pulmonary mycoses can be applied to prevent infection in many cases and to promptly diagnose infectio
Infant nutrition: implication for somatic growth, adult onset diseases, and oral health.: Curr Opin Pediatr. 1997 Jun;9(3):289-97. Unique Identifier : AIDSLINE MED/97373118; Sonis A; Castle J; Duggan C; Nutrition Support Service, Children's Hospital, Boston, MA 02115, USA.; The gold standard for assessing the adequacy of nutrient intake in pediatrics is that diet which promotes optimal growth and development. Thus, it is crucial that our methods for measuring these outcomes be valid, reliable, and widely accepted. A review of the recent medical literature in the field of clinical nutriti
Computer-aided calculation of the local folding potential of target RNA and its use for ribozyme design.: Methods Mol Biol. 1997;74:11-5. Unique Identifier : AIDSLINE MED/97348405; Sczakiel G; Tabler M; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.
Design of the hairpin ribozyme for targeting specific RNA sequences.: Methods Mol Biol. 1997;74:171-7. Unique Identifier : AIDSLINE MED/97348422; Hampel A; DeYoung MB; Galasinski S; Siwkowski A; Department of Biological Sciences, Northern Illinois University,; DeKalb, USA.; The following steps should be taken when designing the hairpin ribozyme to cleave a specific target sequence: 1. Select a target sequence containing BN*GUC where B is C, G, or U. 2. Select the target sequence in areas least likely to have extensive interfering structure. 3. Design the conventional hairpin ribozyme as
Computer analysis of the conservation and uniqueness of ribozyme-targeted HIV sequences.: Methods Mol Biol. 1997;74:27-36. Unique Identifier : AIDSLINE MED/97348407; DeYoung MB; Hampel A; Gladstone Institute of Cardiovascular Biology, San Francisco, CA, USA.
Retroviral delivery and anti-HIV testing of hammerhead ribozymes.: Methods Mol Biol. 1997;74:451-7. Unique Identifier : AIDSLINE MED/97348450; Cagnon L; Rossi J; Department of Molecular Biology, Beckman Research Institute of the; City of Hope, Duarte, CA, USA.
Hairpin ribozyme gene therapy for AIDS.: Methods Mol Biol. 1997;74:459-68. Unique Identifier : AIDSLINE MED/97348451; Duarte EA; Leavitt MC; Yamada O; Yu M; Immusol, San Diego, CA, USA.
Clinical aspects of ribozymes as therapeutics in gene therapy.: Methods Mol Biol. 1997;74:469-86. Unique Identifier : AIDSLINE MED/97348452; Looney D; Yu M; San Diego Veterans Administration Medical Center, CA, USA.
Virus entry: two receptors are better than one.: Trends Microbiol. 1997 Jul;5(7):257-8; discussion 258-9. Unique Identifier : AIDSLINE MED/97378903; Tufaro F; Dept of Microbiology and Immunology, University of British Columbia,; Vancouver, Canada. tufaro@unixg.ubc.ca
T cells and memory lapses.: Trends Microbiol. 1997 Jul;5(7):259-60; discussion 260-1. Unique Identifier : AIDSLINE MED/97378904; Sprent J; Dept of Immunology, Scripps Research Institute, La Jolla, CA 92037,; USA. jsprent@scripps.edu
HIV resources on the Web.: Trends Microbiol. 1997 Jul;5(7):267. Unique Identifier : AIDSLINE MED/97378909
Gastric cryptosporidiosis complicating HIV infection: case report and review of the literature.: Eur J Gastroenterol Hepatol. 1997 Mar;9(3):307-10. Unique Identifier : AIDSLINE MED/97250598; Ventura G; Cauda R; Larocca LM; Riccioni ME; Tumbarello M; Lucia MB; Department of Infectious Diseases, Catholic University, Rome, Italy.; Gastric cryptosporidiosis is rarely reported despite the fact that Cryptosporidium has been recognized with increasing frequency as an aetiological agent of severe chronic diarrhoeal enteritis in patients with human immunodeficiency virus (HIV) infection. We report a case of gastric cryptosporidiosis that occurred in
Development and application of genetic probes for detection of Enterocytozoon bieneusi in formalin-fixed stools and in intestinal biopsy specimens from infected patients.: Clin Diagn Lab Immunol. 1997 Jul;4(4):405-8. Unique Identifier : AIDSLINE MED/97363863; Carville A; Mansfield K; Widmer G; Lackner A; Kotler D; Wiest P; Gumbo T; Sarbah S; Tzipori S; Division of Infectious Diseases, Tufts University School of Veterinary; Medicine, North Grafton, Massachusetts 01536, USA.; The microsporidium Enterocytozoon bieneusi is closely linked to wasting and diarrhea in a high proportion of individuals with AIDS. However, its relative contribution to disease is uncertain because diagnosis until recently depended on procedures involving endoscopy. A sensitive PCR technique which amplifies a fragmen
T-cell, antibody, and cytokine responses to homologs of the 60-kilodalton heat shock protein in Helicobacter pylori infection.: Clin Diagn Lab Immunol. 1997 Jul;4(4):440-6. Unique Identifier : AIDSLINE MED/97363869; Sharma SA; Miller GG; Peek RA Jr; Perez-Perez G; Blaser MJ; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, Tennessee 37232, USA.; For Helicobacter pylori, the hsp60 heat shock protein encoded by hspB is being considered as a potential candidate for subunit vaccines. We investigated the humoral and cellular responses to H. pylori hsp60 and its cross-reactivity with the homologous Mycobacterium bovis p65 protein and autologous human hsp60 protein.
Immunological markers of disease progression in patients infected with the human immunodeficiency virus.: Clin Diagn Lab Immunol. 1997 Jul;4(4):474-7. Unique Identifier : AIDSLINE MED/97363875; Pascale JM; Isaacs MD; Contreras P; Gomez B; Lozano L; Austin E; De Martin MC; Gregory RL; McLaughlin GL; Amador A; Department of Microbiology, Faculty of Medicine, University of Panama,; Panama City.; Identification of inexpensive and technically simple immunological tests useful in predicting the progression to AIDS in human immunodeficiency virus (HIV)-infected patients would be especially welcome in developing countries, in which 80% of HIV-infected patients reside and health budgets are low. In the current stud
Dynamics of RNA-protein interactions in the HIV-1 Rev-RRE complex visualized by 6-thioguanosine-mediated photocrosslinking.: RNA. 1997 Aug;3(8):850-60. Unique Identifier : AIDSLINE MED/97400127; Ping YH; Liu Y; Wang X; Neenhold HR; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical School-UMDNJ,; and Microbiology & Molecular Genetics Graduate Program at Rutgers, The; State University of New Jersey, Piscataway, 08854, USA.; Expression of the structural proteins of human immunodeficiency virus type 1 (HIV-1) requires the direct interaction of multiple copies of the viral protein Rev with its target RNA, the Rev response element (RRE). RRE is a complex 351-nt RNA that is highly structured and located within the viral env gene. During initi
Vulvovaginal tuberculosis: a case report.: Chang Keng I Hsueh. 1997 Mar;20(1):66-70. Unique Identifier : AIDSLINE MED/97321905; Ma YY; Hsu TY; Changchien CC; Chang SY; Lin JW; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital,; Kaohsiung, Taiwan, R.O.C.; A rare case of vulvovaginal tuberculosis is reported. A 76-year-old woman presented with a painful ulcer at the posterior fourchette and lower vagina for 6 weeks. Direct biopsy for histologic examination revealed mycobacterial infection. Anti-tuberculosis treatment was effective for this patient. We suggest prompt bio
Cancer vaccines: challenges and potential solutions.: Mol Med Today. 1997 Jul;3(7):286-90. Unique Identifier : AIDSLINE MED/97401529; Hellstrom KE; Gladstone P; Hellstrom I; Bristol-Myers Squibb Pharmacetuical Research Institute, Seattle, WA; 98121, USA.; Almost a century has passed since immunotherapy of cancer was first attempted using cancer immunogens (vaccines); however, its clinical impact remains modest. Although initial concerns about a lack of human tumor antigens have decreased, prevailing issues include inefficient procedures for immunization and downregulat
Evaluation of the MUREX*ICE HIV-1.O.2 capture enzyme immunoassay for early identification of HIV-1 seroreverting infants in a developing country.: Clin Diagn Virol. 1997 May;8(1):1-8. Unique Identifier : AIDSLINE MED/97391910; Lyons SF; Bowers ET; McGillivray GM; Blackburn NK; Gray GE; Department of Virology, University of the Witwatersrand, Johannesburg,; South Africa. suel@niv.ac.za; BACKGROUND: A simple, inexpensive serological assay is required for the early determination of HIV infection status among infants born to HIV-1-seropositive women in developing countries. OBJECTIVES: To evaluate the use of a commercially available capture enzyme immunoassay (EIA), the MUREX*ICE HIV-1.O.2, for the earl
Interleukin-4 is effective in restoring cytotoxic T cell activity that declines during in vivo progression of a murine B lymphoma.: Cancer Immunol Immunother. 1997 Jul;44(5):291-300. Unique Identifier : AIDSLINE MED/97390707; Santra S; Ghosh SK; Department of Life Sciences, Indiana State University, Terre Haute; 47809, USA.; We previously reported [Chakrabarti et al. (1992) Cell Immunol 142:54; 144:455] that, in a murine B lymphoma model 2C3, idiotype Id)-specific CD8+ cytotoxic T lymphocytes (CTL) are generated in mice following hyperimmunization with irradiated tumor cells, and that they are effective in tumor rejection. The present stu
Accessories for naked DNA vaccines [news]: Nat Biotechnol. 1997 Jul;15(7):619-20. Unique Identifier : AIDSLINE MED/97362794; Levitsky HI
Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes.: Nat Biotechnol. 1997 Jul;15(7):641-6. Unique Identifier : AIDSLINE MED/97362802; Kim JJ; Bagarazzi ML; Trivedi N; Hu Y; Kazahaya K; Wilson DM; Ciccarelli R; Chattergoon MA; Dang K; Mahalingam S; Chalian AA; Agadjanyan MG; Boyer JD; Wang B; Weiner DB; Department of Chemical Engineering, University of Pennsylvania,; Philadelphia 19104, USA.; Nucleic acid immunization is a novel vaccination technique to induce antigen-specific immune responses. We have developed expression cassettes for cell surface markers CD80 and CD86, two functionally related costimulatory molecules that play an important role in the induction of T cell-mediated immune responses. Coimm
Human monoclonal antibodies to viral peptides.: Hum Antibodies. 1997;8(2):65-9. Unique Identifier : AIDSLINE MED/97373191; Sidorova E; Borisova T; Lyakisheva L; Rosen A; Laboratory of Immunoglobulin Biosynthesis, Russian Academy of Medical; Sciences, Moscow, Russia.; A new approach to the developing of human monoclonal antibodies to viral peptides is described. The method is based on the positive selection of B cells specific to viral peptides from normal human tissues. To isolate B cells bearing immunoglobulin receptors specific to viral epitopes magnetic beads coated by viral pe
"For any shortcomings on the part of the Red Cross, we are deeply sorry" [letter; comment]: CMAJ. 1997 Aug 1;157(3):245; discussion 246. Unique Identifier : AIDSLINE MED/97414494; Normand A
"For any shortcomings on the part of the Red Cross, we are deeply sorry" [letter; comment]: CMAJ. 1997 Aug 1;157(3):245-6. Unique Identifier : AIDSLINE MED/97414495; Davey M; Perrault R
Needle exchange programs: an economic evaluation of a local experience [see comments]: CMAJ. 1997 Aug 1;157(3):255-62. Unique Identifier : AIDSLINE MED/97414502; Gold M; Gafni A; Nelligan P; Millson P; Department of Clinical Epidemiology and Biostatistics, McMaster; University, Hamilton, Ont.; OBJECTIVE: To determine whether providing a needle exchange program to prevent HIV transmission among injection drug users would cost less than the health care consequences of not having such a program. DESIGN: Incidence outcome model to estimate the number of cases of HIV infection that this program would prevent ove
Needle exchange: panacea or problem? [editorial; comment]: CMAJ. 1997 Aug 1;157(3):275-7. Unique Identifier : AIDSLINE MED/97414504; Hankins C
Risk of HIV infection from blood transfusion in Montreal [see comments]: CMAJ. 1997 Aug 15;157(4):375-82. Unique Identifier : AIDSLINE MED/97421827; Remis RS; Delage G; Palmer RW; Department of Public Health Sciences, University of Toronto, Ont.; OBJECTIVES: To determine the incidence (including associated donor characteristics and time trends) of HIV infection among repeat blood donors and to estimate the risk of HIV transmission from blood transfusion in Montreal and in Canada as a whole. DESIGN: Retrospective cohort anal
HIV in the blood supply: nothing to fear but fear itself [editorial; comment]: CMAJ. 1997 Aug 15;157(4):391-2. Unique Identifier : AIDSLINE MED/97421829; Strathdee SA; O'Shaughnessy MV; Schechter MT
Associations between farm management practices, productivity, and bovine leukemia virus infection in Ontario dairy herds.: Prev Vet Med. 1997 Aug;31(3-4):211-21. Unique Identifier : AIDSLINE MED/97378848; Sargeant JM; Kelton DF; Martin SW; Mann ED; Department of Population Medicine, University of Guelph, Ontario,; Canada.; The objective of this study was to investigate the associations between herd-level bovine leukemia virus (BLV) status and herd-level management and production variables. The study population consisted of 1330 cows sampled from 102 Ontario dairy herds. The individual-cow prevalence of BLV infection in the population (b
Evaluation of a bulk-milk ELISA test for the classification of herd-level bovine leukemia virus status.: Prev Vet Med. 1997 Aug;31(3-4):223-30. Unique Identifier : AIDSLINE MED/97378849; Sargeant JM; Kelton DF; Martin SW; Mann ED; Department of Population Medicine, University of Guelph, Ontario,; Canada.; The results of a commercial bulk-milk enzyme-linked immunosorbent assay (ELISA) test for herd-level bovine leukemia virus (BLV) status were compared to results obtained from individual agar-gel immunodiffussion (AGID) testing on sampled cattle. A positive herd was defined as a herd having one or more AGID-positive ani
Focus group interview as a data gathering tool: its application to nurses' understanding of HIV infection and AIDS.: Curationis. 1996 Dec;19(4):23-5. Unique Identifier : AIDSLINE MED/97428987; Chamane NJ; Kortenbout W; Department of Nursing, University of Natal.; The focus group interview (FGI) is a research method not commonly used by nurses. It is an effective method if qualitative data are needed and may be used independently to get indepth information, but also can be used in conjunction with tools such as questionnaires, to elicit information that could not be gathered ot
[Knowledge and attitude of nursing students concerning AIDS in 3 educational institutes of the West Cape]: Curationis. 1996 Dec;19(4):64-6. Unique Identifier : AIDSLINE MED/97428995; Bester ME; Arendse Y; Universiteit van Stellenbosch.; A survey was done by means of a questionnaire to obtain information on the knowledge and attitudes of 297 nursing students from three training institutions in the Western Cape regarding HIV-infection and AIDS-patients. Results indicated: The average knowledge regarding AIDS scored 72.5% They generally had a positive a
Comparison of nucleic acid and protein immunization for induction of antibodies specific for HIV-1 gp120.: Clin Exp Immunol. 1997 Aug;109(2):226-32. Unique Identifier : AIDSLINE MED/97420531; Peet NM; McKeating JA; Ramos B; Klonisch T; De Souza JB; Delves PJ; Lund T; Department of Immunology, The Windeyer Institute for Medical Sciences,; University College London Medical School, UK.; We have compared the antibody response to HIV-1 gp120 type LAI in mice immunized with either a gp120 expression plasmid or with baculovirus-derived recombinant gp120 (rgp120) formulated with Freund s complete adjuvant. TiterMax, Alum, Ribi R-700, AF-A or QuilA. DNA immunization resulted in variable levels of antibody,
Cytokine responses to the native and recombinant forms of the major surface glycoprotein of Pneumocystis carinii.: Clin Exp Immunol. 1997 Aug;109(2):255-60. Unique Identifier : AIDSLINE MED/97420535; Theus SA; Smulian AG; Sullivan DW; Walzer PD; Cincinnati Veterans Affairs Medical Centre, Department of Internal; Medicine, University of Cincinnati College of Medicine, OH 45220, USA.; Pneumocystis carinii is a major opportunistic pathogen and leading cause of morbidity in patients with AIDS. The major surface glycoprotein (MSG) of P. carinii, represented by a family of related proteins encoded by unique genes, is highly immunogenic and contains T cell-protective epitopes. We undertook the present s
Hyperinducible expression of the interferon-gamma (IFN-gamma) gene and its suppression in systemic lupus erythematosus (SLE).: Clin Exp Immunol. 1997 Aug;109(2):296-303. Unique Identifier : AIDSLINE MED/97420540; Gerez L; Shkolnik T; Hirschmann O; Lorber M; Arad G; Kaempfer R; Department of Molecular Virology, The Hebrew University-Hadassah; Medical School, Jerusalem, Israel.; Transient expression of IFN-gamma and IL-2 mRNA and its control by post-transcriptional and suppressive mechanisms were analysed in phytohaemagglutinin-induced peripheral blood mononuclear cells PBMC) from 47 patients with SLE and 31 age-matched normal donors, using qu
Antibodies to beta2-glycoprotein I--a specific marker for the antiphospholipid syndrome.: Clin Exp Immunol. 1997 Aug;109(2):304-9. Unique Identifier : AIDSLINE MED/97420541; Guerin J; Feighery C; Sim RB; Jackson J; Department of Immunology, St James' Hospital, Dublin, Ireland.; The antiphospholipid syndrome is a disorder characterized by recurrent thrombosis and the presence of antibodies specific to phospholipids. However, the diagnosis of this syndrome is hampered by the lack of a specific laboratory test. In this study an ELISA for the measurement of antibodies to solid-phase beta2-glycop
Elevation of CD8+ CD11b+ Leu-8- T cells is associated with the humoral immunodeficiency in myeloma patients.: Clin Exp Immunol. 1997 Aug;109(2):310-6. Unique Identifier : AIDSLINE MED/97420542; Walchner M; Wick M; Department of Dermatology, Ludwig-Maximilians-University of Munich,; Germany.; Recurrent bacterial infections due to humoral immunodeficiency are an important cause of death in myeloma patients. Recent data indicate that CD8+ T lymphocytes and a reduction of T helper type 1 cells with disease progression may be involved in the regulation of polyclonal immunoglobulin secretion. In mixed lymphocyt
Therapeutic effects of preferential induction of mite-specific T helper 0 clones.: Clin Exp Immunol. 1997 Aug;109(2):332-41. Unique Identifier : AIDSLINE MED/97420545; Yamashita N; Takeno M; Kaneko S; Mizushima Y; Sakane T; Department of Immunology, Institute of Medical Science, St Marianna; University School of Medicine, Kanagawa, Japan.; The predominance of Th2 cytokine-secreting pattern in allergic asthma has been known as a cause and an accelerating factor, and Th1 suppresses these allergic phenomena, but the role of Th0 clones is obscure. Because Th1/Th2 differentiation has been determined by cytokine environment, we investigated how mite-specific
Non-organ specific autoantibodies against cellular components in HIV-1 infected individuals.: Clin Exp Rheumatol. 1997 Mar-Apr;15(2):185-8. Unique Identifier : AIDSLINE MED/97340373; Kordossis T; Piha L; Guialis A; Kosmopoulou O; Tzioufas AG; Moutsopoulos HM; Department of Pathophysiology, Medical School of Athens, Greece.; OBJECTIVE: To detect the presence of autoantibodies against cellular components in HIV-1 infected individuals. METHODS: Serum samples from 87 patients with HIV-1 infection and from 17 healthy HIV-seronegative controls were tested using sensitive and specific techniques (immunoblot, RNA precipitation), as well as count
Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses.: Clin Pharmacokinet. 1997 Jul;33(1):52-77. Unique Identifier : AIDSLINE MED/97393999; Debruyne D; Laboratory of Pharmacology, University Hospital Center, Caen, France.; The bis triazole agent fluconazole is used widely in the treatment of superficial and deep mycoses. A single oral dose of fluconazole 150 mg gives a mean long term clinical cure rate of 84 +/- 5% and is considered a valuable alternative to other topical antifungal drugs for vaginal candidiasis. A clinical cure rate of
Virus zoonoses--a long-term overview.: Comp Immunol Microbiol Infect Dis. 1997 Feb;20(2):101-9. Unique Identifier : AIDSLINE MED/97351913; Bennett M; Begon ME; Department of Veterinary Clinical Science and Animal Husbandry,; University of Liverpool Veterinary Teaching Hospital, Leahurst,; Neston, South Wirral, UK.
Bovine leukemia virus: early reflections in blood after an experimental infection of calves.: Comp Immunol Microbiol Infect Dis. 1997 Feb;20(2):119-30. Unique Identifier : AIDSLINE MED/97351915; Klintevall K; Fuxler L; Fossum C; National Veterinary Institute, Department of Virology, Uppsala,; Sweden.; In order to study early alterations in the blood following infection with bovine leukemia virus (BLV) in the natural host, 15 calves were inoculated with blood from a BLV-positive donor cow. The humoral immunological response was followed by ELISA for 2 months. Seroconversion to BLV was demonstrated at 4-5 weeks post-
Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: report of two patients and review of the literature.: Crit Care Med. 1997 Aug;25(8):1425-30. Unique Identifier : AIDSLINE MED/97411847; Sundar K; Suarez M; Banogon PE; Shapiro JM; Department of Medicine, St. Luke's/Roosevelt Hospital Center, New; York, NY 10025, USA.
Tuberculous pleurisy is more common in AIDS than in non-AIDS patients with tuberculosis.: Chest. 1997 Aug;112(2):393-7. Unique Identifier : AIDSLINE MED/97410159; Frye MD; Pozsik CJ; Sahn SA; Department of Medicine, Medical University of South Carolina,; Charleston, USA.; OBJECTIVE: To investigate the incidence, clinical features, and treatment of tuberculous pleurisy in AIDS patients. METHODS: We reviewed all cases of pleural tuberculosis in AIDS patients in South Carolina from 1988 through 1994. Clinical findings, test results, treatment, and outcome were analyzed. MAIN RESULTS: Twen
Variations in medical care for HIV-related Pneumocystis carinii pneumonia: a comparison of process and outcome at two hospitals.: Chest. 1997 Aug;112(2):398-405. Unique Identifier : AIDSLINE MED/97410160; Curtis JR; Ullman M; Collier AC; Krone MR; Edlin BR; Bennett CL; Division of Pulmonary and Critical Care Medicine, University of; Washington, Seattle 98104, USA.; BACKGROUND: Institutional variation in the quality of medical care may be evaluated by examining process measures, such as use of diagnostic procedures or treatment modalities, or outcome measures, such as mortality. We undertook this study to examine variations in both process and outcome of care for patients with HI
Primary pulmonary hypertension in a patient with CD8/T-cell large granulocyte leukemia: amelioration by cladribine therapy.: Chest. 1997 Aug;112(2):551-3. Unique Identifier : AIDSLINE MED/97410185; Rossoff LJ; Genovese J; Coleman M; Dantzker DR; Department of Medicine, Long Island Jewish Medical Center, New Hyde; Park, NY 11042, USA.; We report a case of primary pulmonary hypertension in an adult man with CD8/T-cell large granulocyte leukemia. Successful treatment of his leukemia with cladribine resulted in dramatic and sustained improvement of his pulmonary hypertension.
Colposcopic appearance of anal squamous intraepithelial lesions: relationship to histopathology.: Dis Colon Rectum. 1997 Aug;40(8):919-28. Unique Identifier : AIDSLINE MED/97413393; Jay N; Berry JM; Hogeboom CJ; Holly EA; Darragh TM; Palefsky JM; Department of Laboratory Medicine, University of California, San; Francisco, 94143-0100, USA.; PURPOSE: The incidence of anal cancer is increased in men with a history of anal receptive intercourse. Analogous to cervical cancer, whose precursor is cervical high-grade squamous intraepithelial lesion (HSIL), anal cancer may be preceded by anal HSIL. Although not yet proven, detection, follow-up, and treatment of
Species-specific identification of microsporidia in stool and intestinal biopsy specimens by the polymerase chain reaction.: Eur J Clin Microbiol Infect Dis. 1997 May;16(5):369-76. Unique Identifier : AIDSLINE MED/97372237; Kock NP; Petersen H; Fenner T; Sobottka I; Schmetz C; Deplazes P; Pieniazek NJ; Albrecht H; Schottelius J; Section of Parasitology, Bernard Nocht Institute for Tropical; Medicine, Hamburg, Germany.; In view of the increasing number of cases of human microsporidiosis , simple and rapid methods for clear identification of microsporidian parasites to the species level are required. In the present study, the polymerase chain reaction PCR) was used for species-specific
Relevance of clinical and laboratory findings in the diagnosis of cytomegalovirus encephalitis in patients with AIDS.: Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):437-44. Unique Identifier : AIDSLINE MED/97392003; Mussini C; Mongiardo N; Manicardi G; Trenti F; Alessandri A; Paolillo F; Catania A; Portolani M; Pecorari M; Borghi V; Ficarra G; Cossarizza A; De Rienzo B; Department of Internal Medicine, University of Modena, Italy.; A retrospective evaluation was conducted in patients with AIDS and an autopsy diagnosis of cytomegalovirus ( CMV ) encephalitis to determine the relevance of clinical and laboratory findings in establishing a diagnosis. On auto
Addition of lamivudine to the drug regimen in patients with advanced HIV disease on nucleoside therapy [letter]: Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):477-9. Unique Identifier : AIDSLINE MED/97392014; Soriano V; Gomez-Cano M; Castilla J; Laguna F; Gonzalez-Lahoz J
Pulmonary infection with Nocardia species: a report of 10 cases and review.: Eur Respir J. 1997 Jul;10(7):1542-6. Unique Identifier : AIDSLINE MED/97373761; Menendez R; Cordero PJ; Santos M; Gobernado M; Marco V; Pneumology Service, University Hospital La Fe, Valencia, Spain.; Pulmonary nocardiosis (PN) is an infrequent and severe infection due to Nocardia spp., microorganisms that may behave both as opportunists and as primary pathogens. The aim of this study and review was to evaluate the clinical features, evolution and prognostic factors of PN. The study group comprised 10 consecutive p
Changes in local immune functions in Mooren's ulcer.: Yen Ko Hsueh Pao. 1996 Mar;12(1):33-5. Unique Identifier : AIDSLINE MED/97421306; Wang Z; Chen J; Zheng H; Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical; Sciences, Guangzhou, China.; PURPOSE: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease. METHOD: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren s ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, CD1 and
HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid.: FEBS Lett. 1997 Jul 7;411(1):107-9. Unique Identifier : AIDSLINE MED/97388318; Vesce S; Bezzi P; Rossi D; Meldolesi J; Volterra A; Institute of Pharmacological Sciences, University of Milan, Italy.; The mechanisms of HIV-1 neurotoxicity remain still undefined although the induction of signalling events and a modest inhibition of glutamate uptake induced by the envelope glycoprotein, gp120, have called attention to astrocytes. Here we demonstrate that the levels at which the viral glycoprotein affects glutamate ho
Nuclear levels of NF-kappaB correlate with syncytium-forming capacity of 8e51 cells, expressing a defective HIV virus.: FEBS Lett. 1997 Jul 28;412(2):277-80. Unique Identifier : AIDSLINE MED/97398336; Guerrini L; De Santis C; Robbioni P; Beretta A; Blasi F; Department of Genetics and Microbial Biology, University of Milan,; Italy.; The double NF-kappaB site identified in the LTR of the human immunodeficiency virus-1 (HIV-1) has been demonstrated to be necessary for efficient viral transcription. In this report we present the characterisation of NF-kappaB subunits engaged in complexes binding to the HIV-1 NF-kappaB site in human 8e51 T-cells, tha
Clastogenic factors in plasma of HIV-1 infected patients activate HIV-1 replication in vitro: inhibition by superoxide dismutase.: Free Radic Biol Med. 1997;23(4):571-8. Unique Identifier : AIDSLINE MED/97358707; Edeas MA; Emerit I; Khalfoun Y; Lazizi Y; Cernjavski L; Levy A; Lindenbaum A; Department of Biochemistry, Hopital Antoine Beclere, Clamart, France.; The frequent neoplastic disorders present in HIV-infected patients and the implication of oxidative stress in AIDS-Kaposi s sarcoma pathogenesis prompted us to study whether the mechanisms implicated in genotoxic effects of clastogenic factors (CFs) i.e., chromosome damaging materials released by cells under condition
Lamivudine treatment of advanced and decompensated liver disease due to hepatitis B.: Hepatogastroenterology. 1997 May-Jun;44(15):808-12. Unique Identifier : AIDSLINE MED/97365868; Van Thiel DH; Friedlander L; Kania RJ; Molloy PJ; Hassanein T; Wahlstrom E; Faruki H; Department of Medicine, University of Kentucky School of Medicine,; Lexington, USA.; The purpose of this study was to evaluate the effectiveness and safety of lamivudine treatment in patients with advanced and end-stage liver disease caused by hepatitis B. Nine cases of advanced or end-stage liver disease due to hepatitis B infection were treated with lamivudine. Four received liver transplants while
Comparison of nursing interventions classification and current procedural terminology codes for categorizing nursing activities.: Image J Nurs Sch. 1997;29(2):133-8. Unique Identifier : AIDSLINE MED/97356035; Henry SB; Holzemer WL; Randell C; Hsieh SF; Miller TJ; Department of Community Health Systems, University of California, San; Francisco 94143-0608, USA.; PURPOSE: To compare the frequency with which nursing activity terms could be categorized using Nursing Interventions Classification (NIC) and Current Procedural Terminology (CPT) codes. DESIGN: Descriptive. The sample was 201 patients with AIDS hospitalized 1989-1992 for pneumocystis carinii pneumonia in three US medi
Modelling the impact of HIV disease on mortality in gay and bisexual men.: Int J Epidemiol. 1997 Jun;26(3):657-61. Unique Identifier : AIDSLINE MED/97365966; Hogg RS; Strathdee SA; Craib KJ; O'Shaughnessy MV; Montaner JS; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To assess how HIV infection and AIDS (HIV/AIDS) impacts on mortality rates for gay and bisexual men. METHODS: Vital statistics data were obtained for a large Canadian urban centre from 1987 to 1992. Three scenarios were utilized with assumed proportions of gay and bisexual men of 3%, 6% and 9% among the mal
[Prison environment, HIV/AIDS and health promotion (letter)]: Gac Sanit. 1997 Jan-Feb;11(1):45-7. Unique Identifier : AIDSLINE MED/97405383; Paredes J; Colomer C
Recurrent 'migrainelike' episodes in patients with HIV disease.: Headache. 1997 Jul-Aug;37(7):443-8. Unique Identifier : AIDSLINE MED/97422986; Rinaldi R; Manfredi R; Azzimondi G; Rodorigo G; Tonon C; De Rosa V; Mastroianni A; Coronado OV; Legnani C; Chiodo F; D'Alessandro R; Neurology Unit, University of Bologna, Italy.; Recurrent transient neurological deficits have been described in human immunodeficiency virus (HIV)-infected subjects, but their frequency, pathogenesis, and outcome are still unsettled. We describe 10 HIV-infected patients with transient neurological deficits (0.8% of all patients followed in our department during th
Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR.: J Biol Chem. 1997 Aug 8;272(32):20191-7. Unique Identifier : AIDSLINE MED/97390463; Ray P; Yang L; Zhang DH; Ghosh SK; Ray A; Department of Internal Medicine, Pulmonary and Critical Care Section,; Yale University School of Medicine, New Haven, Connecticut 06520, USA.; Prabir.Ray@qm.yale.edu; We previously reported the cloning of a cDNA for IkappaBR (for IkappaB-related) from human lung alveolar epithelial cells. IkappaBR is related to the IkappaB proteins that function as regulators of the NF-kappaB family of transcription factors. Here, we investigated the consequence of IkappaBR overexpression on the ex
Lamivudine resistance in immunocompetent chronic hepatitis B. Incidence and patterns.: J Hepatol. 1997 Jun;26(6):1393-5. Unique Identifier : AIDSLINE MED/97354334; Honkoop P; Niesters HG; de Man RA; Osterhaus AD; Schalm SW; Department of Internal Medicine II, Erasmus University Hospital; Rotterdam, The Netherlands.; BACKGROUND: Lamivudine is a non-toxic, potent inhibitor of hepatitis B virus replication. Recently, hepatitis B virus resistance to lamivudine has been described in patients using immunosuppressive drugs after liver transplantation. METHODS: From our
Association between leprosy and HIV infection in Tanzania.: Int J Lepr Other Mycobact Dis. 1997 Jun;65(2):203-10. Unique Identifier : AIDSLINE MED/97395454; van den Broek J; Chum HJ; Swai R; O'Brien RJ; Ministry of Health, Tuberculosis and Leprosy Central Unit, Dar es; Salaam, Tanzania.; SETTING: An epidemiological study of the interaction of leprosy and HIV infection in Tanzania . OBJECTIVE: To establish the prevalence of HIV infection among leprosy patients, and to measure the association of HIV and leprosy by comparing the HIV prevalence in leprosy patients and
Tolerance induction and autoimmune encephalomyelitis amelioration after administration of myelin basic protein-derived peptide.: J Exp Med. 1997 Aug 18;186(4):507-15. Unique Identifier : AIDSLINE MED/97402482; Tonegawa SMS; Howard Hughes Medical Institute, Center for Cancer Research,; Department of Biology, Massachusetts Institute of Technology,; Cambridge, Massachusetts 02139, USA.; Experimental autoimmune encephalomyelitis (EAE), a demyelinating disease of the central nervous system, is an animal model of paralyzing human disease, multiple sclerosis. EAE is readily induced by immunization with myelin basic protein (MBP) in mice transgenic for an alphabeta T cell receptor (TCR) that is specific f
Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes.: J Exp Med. 1997 Aug 18;186(4):589-600. Unique Identifier : AIDSLINE MED/97402490; Salmi M; Tohka S; Berg EL; Butcher EC; Jalkanen S; National Public Health Institute, and MediCity Research Laboratory,; Turku University, 20520 Turku, Finland. marko.salmi@utu.fi; Interactions between lymphocyte surface receptors and their ligands on vascular endothelial cells regulate the exit of lymphocytes from the circulation. Distinct subsets of mononuclear cells bind to high endothelial venules (HEVs) in different lymphoid organs to a different extent, but the molecular mechanisms behind
Kinetics of viral RNA synthesis following cell-to-cell transmission of human immunodeficiency virus type 1.: J Gen Virol. 1997 Aug;78 ( Pt 8):1897-906. Unique Identifier : AIDSLINE MED/97410270; Davis AJ; Li P; Burrell CJ; National Centre for HIV Virology Research, Institute of Medical and; Veterinary Science, Adelaide, Australia.; The temporal appearance and levels of human immunodeficiency virus type 1 (HIV-1) tat, rev, nef, env and gag mRNA species were examined using a synchronized, one-step, cell-to-cell HIV-1 infection model involving HUT-78 cells and HIV- 1 persistently infected H3B cells. Individual mRNAs were quantified by RT-PCR using
Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositol-anchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction.: J Gen Virol. 1997 Aug;78 ( Pt 8):1907-11. Unique Identifier : AIDSLINE MED/97410271; Saifuddin M; Hedayati T; Atkinson JP; Holguin MH; Parker CJ; Spear GT; Department of Immunology/Microbiology, Rush University, Chicago, IL; 60612, USA. msaifudd@rush.edu; Human immunodeficiency virus type 1 (HIV-1) can be either resistant or sensitive to complement-mediated destruction depending on the host cells. Incorporation of different levels of host cell CD46, CD55 and CD59 may account for this differential sensitivity to complement. However, it has not been determined whether CD
Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS.: J Gen Virol. 1997 Aug;78 ( Pt 8):1913-8. Unique Identifier : AIDSLINE MED/97410272; van Baalen CA; Pontesilli O; Huisman RC; Geretti AM; Klein MR; de Wolf F; Miedema F; Gruters RA; Osterhaus AD; Institute of Virology, Erasmus University Rotterdam, The Netherlands.; Immunological correlates of AIDS-free survival after human immunodeficiency virus type 1 (HIV-1) infection are largely unknown. Cytotoxic T lymphocyte (CTL) responses are generally believed to be a major component of protective immunity against viral infections. However, the relationship between HIV-1-specific CTL res
Mechanisms of protection induced by attenuated simian immunodeficiency virus. I. Protection cannot be transferred with immune serum.: J Gen Virol. 1997 Aug;78 ( Pt 8):1919-22. Unique Identifier : AIDSLINE MED/97410273; Almond N; Rose J; Sangster R; Silvera P; Stebbings R; Walker B; Stott EJ; AIDS Collaborating Centre, National Institute for Biological Standards; and Control, Potters Bar, Herts, UK. nalmond@nibsc.ac.uk; To evaluate its role in protection, immune serum was collected from four macaques which were chronically infected with live attenuated simian immunodeficiency virus (SIVmacC8) and had resisted challenge with wild-type SIVmacJ5. The immune serum was transferred to two naive cynomolgus macaques by intraperitoneal inject
Macaques infected with attenuated simian immunodeficiency virus resist superinfection with virulence-revertant virus.: J Gen Virol. 1997 Aug;78 ( Pt 8):1923-7. Unique Identifier : AIDSLINE MED/97410274; Sharpe SA; Whatmore AM; Hall GA; Cranage MP; Centre for Applied Microbiology and Research, Porton Down, Salisbury,; UK.; Macaques infected with attenuated simian immunodeficiency virus SIVmac) can resist superinfection challenge with virulent virus, showing the potential of live attenuated virus as an AIDS vaccine. Superinfection resistance does not, however, prevent the generation of virulent virus in vivo, suggesting that such virus m
Use of the bovine leukaemia virus LTR U3 promoter for expressing antisense antiviral RNAs and competitive inhibition of viral infection in cell culture.: J Gen Virol. 1997 Aug;78 ( Pt 8):1941-8. Unique Identifier : AIDSLINE MED/97410277; Shayakhmetov D; Kovalenko D; Yurov G; Borisenko A; Tikchonenko T; Department of Genetic Engineering, Institute of Agricultural; Biotechnology, Moscow, Russia.; Use of viral inducible promoters which can be activated by virus-specific transactivator proteins to drive expression of antisense (as)RNA genes appears to be an attractive approach to inhibit virus infections in vivo. To this end, we have constructed an asRNA gene expressed from the bovine leukaemia virus (BLV) U3 pr
Apoptosis of cord blood T lymphocytes by herpes simplex virus type 1.: J Gen Virol. 1997 Aug;78 ( Pt 8):1971-5. Unique Identifier : AIDSLINE MED/97410281; Ito M; Koide W; Watanabe M; Kamiya H; Sakurai M; Department of Pediatrics, Mie University School of Medicine, Tsu,; Japan. virus@clin.medic.mie-u.ac.jp; We investigated apoptosis induced by herpes simplex virus type 1 HSV-1) in cord blood T lymphocytes by using agarose gel electrophoresis, DNA content analysis and the terminal deoxytransferase (TdT)-mediated dUTP nick end-labelling (TUNEL) method. DNA fragmentation and the hypodiploid fraction in the cell cycle were b
Immunological control of murine gammaherpesvirus infection is independent of perforin.: J Gen Virol. 1997 Aug;78 ( Pt 8):2025-30. Unique Identifier : AIDSLINE MED/97410288; Usherwood EJ; Brooks JW; Sarawar SR; Cardin RD; Young WD; Allen DJ; Doherty PC; Nash AA; Department of Veterinary Pathology, University of Edinburgh,; Summerhall, UK.; Perforin-mediated cytotoxic T cell killing has been suggested to be of importance in the control of noncytopathic virus infections, based on studies with lymphocytic choriomeningitis virus (LCMV). We examined the role of perforin in a mouse model of gammaherpesvirus infection using transgenic perforin-deficient mice.
Delayed positive thallium uptake in large B-cell non-Hodgkin's malignant lymphoma.: J Nucl Med. 1997 Aug;38(8):1213-5. Unique Identifier : AIDSLINE MED/97399024; Abdel-Dayem HM; Naddaf SY; Omar WS; Aziz M; Gillooley J; Department of Radiology, Saint Vincent's Hospital and Medical Center,; New York, NY 10011, USA.; We report an unusual finding in an AIDS patient who presented with a large mediastinal mass and multiple lymphadenopathy. A sequential thallium and gallium scan to specify the nature of the mediastinal mass was requested. The early thallium images, acquired 15 min after the intravenous injection, showed no uptake in t
Association between expression of intercellular adhesion molecule-1 and integration of human T-cell-leukemia virus type 1 in adult T-cell leukemia cells.: J Clin Lab Anal. 1997;11(4):186-9. Unique Identifier : AIDSLINE MED/97362594; Motoya S; Tsujisaki M; Jinnohara T; Sasaki S; Nakano T; Hinoda Y; Imai K; First Department of Internal Medicine, Sapporo Medical University; School of Medicine, Japan.; It is known that the expression levels of intercellular adhesion molecule-1 (ICAM-1) in adult T cell leukemia(ATL) cells are high, whereas those in T-lymphoid cells are not. In order to investigate the factors that influence the induction of ICAM-1 molecules, Northern blot analysis to measure the expression level of I
Evaluation of the second generation IMx Toxo IgG antibody assay for detection of antibodies to Toxoplasma gondii in human sera.: J Clin Lab Anal. 1997;11(4):214-9. Unique Identifier : AIDSLINE MED/97362599; De Champs C; Pelloux H; Cambon M; Fricker-Hidalgo H; Goullier-Fleuret A; Ambroise-Thomas P; Departement de Parasitologie, Mycologie Medicale et Moleculaire,; Centre Hospitalier Universitaire, Grenoble, France.; For an evaluation of the Abbott IMx Toxo IgG second generation, antibodies to Toxoplasma gondii were detected by Abbott IMx Toxo IgG and IgM, Vidas Toxo IgG and Toxo IgM (bioMerieux, France ) with immunofluorescence assay verified by the dye-test for IgG, and immunosorbent agglutina
Arthritis and HIV infection in Kigali, Rwanda, and Paris, France [letter]: J Rheumatol. 1997 Jul;24(7):1449-50. Unique Identifier : AIDSLINE MED/97371892; Blanche P; Sicard D; Saraux A; Taelman H
An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.: J Med Chem. 1997 Aug 1;40(16):2440-4. Unique Identifier : AIDSLINE MED/97402971; Smith AB 3rd; Hirschmann R; Pasternak A; Yao W; Sprengeler PA; Holloway MK; Kuo LC; Chen Z; Darke PL; Schleif WA; Department of Chemistry, University of Pennsylvania, Philadelphia; 19104, USA.
Synthesis and in vitro activity of long-chain 5'-O-[(alkoxycarbonyl)phosphinyl]-3'-azido-3'-deoxythymidines against wild-type and AZT- and foscarnet-resistant strains of HIV-1.: J Med Chem. 1997 Aug 1;40(16):2482-90. Unique Identifier : AIDSLINE MED/97402977; Rosowsky A; Fu H; Pai N; Mellors J; Richman DD; Hostetler KY; Dana-Farber Cancer Institute, Harvard Medical School, Boston,; Massachusetts 02115, USA.; Lipophilic esters of 3 -azido-3 -deoxy-5 -O-(carboxyphosphinyl)thymidine (PFA- AZT ) were synthesized and tested for antiretroviral activity in CD4+ HT4-6C cells infected with either wild-type HIV-1LAI, a PFA-resistant strain encoding a single-point mut
Gene therapy: mastering the basics, defining details [news]: J Natl Cancer Inst. 1997 Aug 20;89(16):1182-4. Unique Identifier : AIDSLINE MED/97418832; Jenks S
Debating dual AIDS guidelines [news]: JAMA. 1997 Aug 27;278(8):613-4. Unique Identifier : AIDSLINE MED/97417504; Voelker R
[Cytokine gene expression in Th1 and Th2: its molecular mechanism and clinical implication]: Nippon Rinsho. 1997 Jun;55(6):1431-7. Unique Identifier : AIDSLINE MED/97344518; Naito Y; Amasaki Y; Department of Anesthesia, Kobe City General Hospital.; Activation of helper T-cells mediated by the T-cell receptor induces a series of biochemical events. Among them, both the activation of PKC/Ras- and CaM/CN-mediated pathways play a central role in the signal transduction of cytokine gene induction. Cytokines produced by non-transformed Th1 and Th2 clones were classifi
[An imbalance between Th1 and Th2-like cytokines in patients with autoimmune diseases--differential diagnosis between Th1 dominant autoimmune diseases and Th2 dominant autoimmune diseases]: Nippon Rinsho. 1997 Jun;55(6):1438-43. Unique Identifier : AIDSLINE MED/97344519; Ishida H; Ota H; Yanagida H; Dobashi H; Department of Internal Medicine, National Utano Hospital.; An imbalance between T helper cell (Th)1 and Th2-like cytokines has been described in several autoimmune diseases. Organ specific autoimmune diseases such as multiple sclerosis (MS) and inflammatory bowel diseases (IBD) are caused by Th1 dominant immune responses. On the contrary, systemic autoimmune diseases such as
[The mechanisms of oral tolerance]: Nippon Rinsho. 1997 Jun;55(6):1444-9. Unique Identifier : AIDSLINE MED/97344520; Yamamoto M; Kweon MN; Kiyono H; Immunobiology Vaccine Center, University of Alabama at Birmingham,; USA.; Oral or nasal administration of a single high dose or repeated mucosal delivery of low doses of proteins have been shown to induce systemic unresponsiveness in the presence of mucosal IgA responses. The induction of oral tolerance(or mucosally-induced tolerance) is mediated by T cells involved in the generation of act
[Pathomechanism of HTLV-I associated arthropathy and the role of tax gene]: Nippon Rinsho. 1997 Jun;55(6):1482-5. Unique Identifier : AIDSLINE MED/97344526; Hasunuma T; Institute of Medical Science, St. Marianna University School of; Medicine.; HTLV-I is known to be a causative agent for adult T cell leukemia. Recent studies revealed this virus is also related to several autoimmune disorders, such as arthropathy, myelopathy and Sjogren s syndrome. We studied etiology of HTLV-I associated arthropathy (HAAP), and found that tax is a causative gene for synovial
[Autoimmune rheumatic diseases associated with HIV infection and its pathogenesis]: Nippon Rinsho. 1997 Jun;55(6):1486-91. Unique Identifier : AIDSLINE MED/97344527; Matsumoto Y; Nagoya City University Medical School.; In autoimmune rheumatic diseases, retroviruses have been repeatedly discussed as important etiologic factors. However, despite a considerable amount of indirect evidence that retroviruses might indeed be involved in triggering or initiating autoimmune rheumatic diseases, clear cut direct evidence is still missing. Stu
[T cell vaccination--induction of anti-idiotypic immune response against TCR and shift of Th1/Th2 balance]: Nippon Rinsho. 1997 Jun;55(6):1512-8. Unique Identifier : AIDSLINE MED/97344531; Kakimoto K; Hara H; Department of Clinical Investigation, Hara-doi Hospital.; T cell vaccination, originally contrived and coinned by I.R. Cohen is the injection of autoimmune pathogenic T cell line/clone or T cell receptor peptides in an attempt to induce anti-idiotypic regulation to treat autoimmune disease. Establishment of many T cell lines/clones from various autoimmune animal model and su
[HIV infection and long-term non progressor]: Nippon Rinsho. 1997 Jun;55(6):1563-71. Unique Identifier : AIDSLINE MED/97344539; Suzuki Y; Yamamoto N; Department of Microbiology, Tokyo Medical and Dental University School; of Medicine.; AIDS(acquired immunodeficiency syndrome) is caused by HIV(human immunodeficiency virus) that belongs to the lentivirus group. Generally, the length of time between HIV infection and development of AIDS is considered to be 10 years on average, but a few percent of infected persons-so-called long-term non progressor, do
Glycodelins GdA and GdS modified by 3-hydroxyphthalic anhydride inhibit gp120-CD4 binding and HIV-1 infection in vitro.: Lab Invest. 1997 Aug;77(2):127-30. Unique Identifier : AIDSLINE MED/97418778; Seppala M; Jiang S; Strick N; Lin K; Li YY; Koistinen H; Koistinen R; Neurath AR; Department of Obstetrics and Gynecology, Helsinki University Central; Hospital, Finland.; Bovine beta-lactoglobulin chemically modified with 3-hydroxyphthalic anhydride (3HP) was recently shown, at nanomolar concentrations, to block the binding site on CD4 for the HIV surface glycoprotein (gp120), potentially inhibiting HIV transmission. Human glycodelin has sequence homology with bovine beta-lactoglobulin
Breast cancer in a man with human immunodeficiency virus infection.: Mayo Clin Proc. 1997 Aug;72(8):761-4. Unique Identifier : AIDSLINE MED/97420620; Widrick P; Boguniewicz A; Nazeer T; Remick SC; Division of Medical Oncology, Albany Medical College, New York, USA.; Non-acquired immunodeficiency syndrome (AIDS)-defining neoplasms are being increasingly recognized in patients infected with the human immunodeficiency virus (HIV). The incidence of Hodgkin s disease and seminoma has recently been reported to be increasing in these patients. This article describes the second case of b
Reliability, validity, and composition of a subset of the Centers for Disease Control and Prevention acquired immunodeficiency syndrome knowledge questionnaire in a sample of homeless and impoverished adults.: Med Care. 1997 Aug;35(8):747-55. Unique Identifier : AIDSLINE MED/97412135; Leake B; Nyamathi A; Gelberg L; School of Medicine, University of California, Los Angeles 90095-6918,; USA.; OBJECTIVES. Measures of acquired immunodeficiency syndrome AIDS)-related knowledge that have good psychometric properties are needed to evaluate the impact of educational interventions, particularly among impoverished populations. Few measures that satisfy these requirements are available. The authors describe the psy
[Aphthae (editorial)]: Med Clin (Barc). 1997 Jun 14;109(3):95-7. Unique Identifier : AIDSLINE MED/97405110; Coll J
[Splenectomy as the treatment in a case of recurrent thrombotic thrombocytopenic purpura in a patient with HIV infection letter)]: Med Clin (Barc). 1997 Jun 21;109(4):156. Unique Identifier : AIDSLINE MED/97403520; Rodriguez-Bano J; Muniain MA; Gutierrez MD; Perez Alonso JL
[Rifabutin as a cause of curable visual alterations in patients with human immunodeficiency virus infection (letter)]: Med Clin (Barc). 1997 Jul 5;109(6):239. Unique Identifier : AIDSLINE MED/97401496; Fernandez Pena CM; Morano Amado LE; Suarez JA; Alvarez ML
[Bacterial cultures and follow up visits instead of penicillin. Diagnostic aids and free of charge follow ups can reduce the use of antibiotics]: Lakartidningen. 1997 Aug 6;94(32-33):2733-5. Unique Identifier : AIDSLINE MED/97421347; Leonardsson-Hellgren M; Svensson N; Hentorps v~ardcentral, Skovde.
Cypriot sentenced for infecting woman with HIV-1 [news]: Lancet. 1997 Aug 9;350(9075):422. Unique Identifier : AIDSLINE MED/97406203; Mitchell P
[AIDS and HIV infection in the Federal Islamic Republic of Comores (1988-1995)]: Med Trop (Mars). 1997;57(1):59-61. Unique Identifier : AIDSLINE MED/97391061; Toyb M; Lombart JP; Binti Abdou A; Oumadi A; Molines C; Josse R; Programme National de Lutte contre le Sida et les MST, RFI des; Comores, Moroni, Republique Federale Islamique des Comores.; Since 1991 AIDS and HIV infection in the Federal Islamic Republic of the Comoros have been monitored through a network of sentinel sites including predetermined target populations. In all cases seropositivity for HIV was confirmed by western blotting after two ELISA screening test
[Recurrent varicella and HIV infection. Apropos of 10 cases seen in Lome]: Med Trop (Mars). 1997;57(1):65-7. Unique Identifier : AIDSLINE MED/97391063; Pitche P; Gbadoe AE; Tidjani O; Tchangai-Walla K; Service de Dermatologie et Venereologie, Centre Hospitalier et; Universitaire Tokoin, Lome, Togo.; Herpes-zoster is commonly observed in immunodepressed patients with HIV infection in Africa. It is due to reactivation of the varicella-zoster virus. Varicella which is usually considered as the acute invasive phase of infection can recur in the same subject during immunodepression, thus constituting recurrent varicel
[Clinico-diagnostic and odonto-stomatologic therapeutic problems in patients with HIV infection and AIDS]: Minerva Stomatol. 1997 Jun;46(6):307-28. Unique Identifier : AIDSLINE MED/97414412; Spadari F; Fazio N; Lauritano D; Zambellini Artini M; Cattedra di Ortognatodonzia, Universita degli Studi, Milano.; During the last decade, scientific studies and new knowledges concerning HIV infection and AIDS, have constituted one of the main topics for discussion in the fields of biology and medicine. AIDS is a serious disease and it is unfortunately characterized by a very high death rate. In spite of all the efforts deployed
Activated CD8+ T cells are involved in elimination of Candida albicans from the livers of mice.: Mycoses. 1997 Jan-Feb;40(1-2):41-6. Unique Identifier : AIDSLINE MED/97407209; Kretschmar M; Jung C; Fontagnier E; Quade B; Nichterlein T; Hof H; Institute of Medical Microbiology and Hygiene, University of; Heidelberg, Mannheim, Germany.; We have investigated the course of infection of Balb/c mice with Candida albicans. After intravenous infection of mice, the yeasts were evenly distributed in the liver sections. There was a 90% reduction in the yeasts found within 7 days after infection. This reduction was accompanied by an increase in the number of p
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team [see comments]: N Engl J Med. 1997 Sep 11;337(11):725-33. Unique Identifier : AIDSLINE MED/97413573; Hammer SM; Squires KE; Hughes MD; Grimes JM; Demeter LM; Currier JS; Eron JJ Jr; Feinberg JE; Balfour HH Jr; Deyton LR; Chodakewitz JA; Fischl MA; Harvard Medical School, Boston, MA, USA.; BACKGROUND: The efficacy and safety of adding a protease inhibitor to two nucleoside analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear. We compared treatment with the protease inhibitor indinavir in addition to zid
Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy [see comments]: N Engl J Med. 1997 Sep 11;337(11):734-9. Unique Identifier : AIDSLINE MED/97413574; Gulick RM; Mellors JW; Havlir D; Eron JJ; Gonzalez C; McMahon D; Richman DD; Valentine FT; Jonas L; Meibohm A; Emini EA; Chodakewitz JA; New York University School of Medicine, New York 10016, USA.; BACKGROUND: The new protease inhibitors are potent inhibitors of the human immunodeficiency virus (HIV), and in combination with other antiretroviral drugs they may be able to cause profound and sustained suppression of HIV replication. METHODS: In this double-blind
Images in clinical medicine. HIV-associated nephropathy.: N Engl J Med. 1997 Sep 11;337(11):754. Unique Identifier : AIDSLINE MED/97413577; Tan SY; O'Donnell PJ; King's College Hospital, London, United Kingdom.
Battling HIV on many fronts [editorial; comment]: N Engl J Med. 1997 Sep 11;337(11):779-81. Unique Identifier : AIDSLINE MED/97413581; Steinbrook R
HIV case study [letter; comment]: Nurse Pract. 1997 Jul;22(7):7, 157-8. Unique Identifier : AIDSLINE MED/97396854; Leiner S
Two Encephalitozoon cuniculi strains of human origin are infectious to rabbits.: Parasitology. 1997 Jan;114 ( Pt 1):29-35. Unique Identifier : AIDSLINE MED/97164380; Mathis A; Michel M; Kuster H; Muller C; Weber R; Deplazes P; Institute of Parasitology, University of Zurich, Switzerland.; The microsporidian Encephalitozoon cuniculi can infect a wide variety of mammals including man. In this study, E. cuniculi isolates of animal origin were compared with 6 isolates obtained from HIV-infected patients. Based on results of Western blot analysis, random amplified polymorphic DNA (RAPD) and the sequence of
Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease.: Parasitology. 1997 Jan;114 ( Pt 1):7-12. Unique Identifier : AIDSLINE MED/97164378; Hermsen C; van de Wiel T; Mommers E; Sauerwein R; Eling W; University of Nijmegen, Department of Medical Microbiology, The; Netherlands. r.hermsen@mmb.azn.nl; The role of T-cells in development of experimental cerebral malaria was analysed in C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected bef
Cytokines, viruses and macrophages: an interactive network. An immune dysregulation involving the members of the tumor necrosis factor (TNF) receptor superfamily could be critical in AIDS pathogenesis.: Pathol Biol (Paris). 1997 Feb;45(2):115-25. Unique Identifier : AIDSLINE MED/97389981; Herbein G; Picower Institute for Medical Research, Laboratory of Molecular; Virology, Manhasset, New York, USA.; Both macrophages and cytokines are components of the immune defense against viral infections. Among cytokines, interferons have been the most studied and interferon-gamma which is secreted by T cells and NK cells activates macrophages which synthesize both interferon-alpha and beta which have powerful antiviral activi
[HIV and macrophage]: Pathol Biol (Paris). 1997 Feb;45(2):137-45. Unique Identifier : AIDSLINE MED/97389984; Russo-Marie F; Institut Cochin de Genetique Moleculaire, INSERM U 332, Paris, France.; The macrophage is the chief target of the HIV, as well as its main vector. Macrophages are infected very early by monocytotropic HIV strains. They are not destroyed, and probably contribute both to host defense mechanisms and to perpetuation and dissemination of the infection. HIV-infected macrophages have been demons
Call for mandatory HIV accident rules [news]: Nurs Times. 1997 Jul 9-15;93(28):10. Unique Identifier : AIDSLINE MED/97423244; Porter R
Stretched to breaking point.: Nurs Times. 1997 Jul 16-22;93(29):29-30. Unique Identifier : AIDSLINE MED/97423272
How a primary care specialist role for HIV/AIDS was set up.: Nurs Times. 1997 Jul 16-22;93(29):59-60. Unique Identifier : AIDSLINE MED/97423281; Taylor L; Rink E; Lempp H; Health First, London.
Acute sinusitis in adults. Difficult to diagnose, essential to treat.: Postgrad Med. 1997 Aug;102(2):253-8. Unique Identifier : AIDSLINE MED/97416764; Kankam CG; Sallis R; Kaiser Permanente Medical Center, Fontana, California, USA.; edkankam@aol.com; Acute sinusitis is difficult to diagnose. Diagnosis depends on obtaining a complete history and physical examination in addition to use of radiographic diagnostic aids and, if necessary, sinus aspiration. Once the diagnosis is made, empirical treatment with antibiotic agents and adjunctive measures should be started.
Pseudotyping of murine leukemia virus with the envelope glycoproteins of HIV generates a retroviral vector with specificity of infection for CD4-expressing cells.: Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8640-5. Unique Identifier : AIDSLINE MED/97385156; Schnierle BS; Stitz J; Bosch V; Nocken F; Merget-Millitzer H; Engelstadter M; Kurth R; Groner B; Cichutek K; Institut fur Experimentelle Krebsforschung, Klinik fur Tumorbiologie,; Breisacher Strasse 117, D-79106 Freiburg, Germany.; CD4-expressing T cells in lymphoid organs are infected by the primary strains of HIV and represent one of the main sources of virus replication. Gene therapy strategies are being developed that allow the transfer of exogenous genes into CD4(+) T lymphocytes whose expression might prevent viral infection or replication
CCAAT/enhancer binding protein (C/EBP) sites are required for HIV-1 replication in primary macrophages but not CD4(+) T cells.: Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8714-9. Unique Identifier : AIDSLINE MED/97385169; Henderson AJ; Calame KL; Department of Microbiology, Columbia University, College of Physicians; and Surgeons, 701 West 168th Street, New York, NY 10032, USA.; The importance of CCAAT/enhancer binding proteins (C/EBPs) and binding sites for HIV-1 replication in primary macrophages, T cell lines and primary CD4(+) T cells was examined. When lines overexpressing the C/EBP dominant-negative protein LIP were infected with HIV-1, replication occurred in Jurkat T cells but not in
DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life.: Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8726-31. Unique Identifier : AIDSLINE MED/97385171; Martinez X; Brandt C; Saddallah F; Tougne C; Barrios C; Wild F; Dougan G; Lambert PH; Siegrist CA; World Health Organization Collaborating Centre for Neonatal; Vaccinology, Department of Pathology, University of Geneva, 1211; Geneva 4, Switzerland.; The relative deficiency of T helper type 1 (Th1) and cytotoxic T lymphocyte (CTL) responses in early life is associated with an increased susceptibility to infections by intracellular microorganisms. This is likely to reflect a preferential polarization of immature CD4 T cells toward a Th2 rather than a Th1 pattern up
Procedures for embalming cadavers for the dissecting laboratory.: Proc Soc Exp Biol Med. 1997 Sep;215(4):363-5. Unique Identifier : AIDSLINE MED/97416768; Macdonald GJ; MacGregor DB; Department of Neuroscience and Cell Biology, University of Medicine; and Dentistry of New Jersey, Robert Wood Johnson Medical School,; Piscataway 08854, USA.
[The battle against AIDS in not yet won]: Pharm Unserer Zeit. 1997 Mar;26(2):103-4. Unique Identifier : AIDSLINE MED/97350583
[Aids]: Pharm Unserer Zeit. 1997 Mar;26(2):87. Unique Identifier : AIDSLINE MED/97350581; Brede HD
Circulating cell adhesion molecules in HIV1-infected patients as indicator markers for AIDS progression.: Res Immunol. 1997 Feb;148(2):109-17. Unique Identifier : AIDSLINE MED/97370416; Galea P; Vermot-Desroches C; Le Contel C; Wijdenes J; Chermann JC; INSERM U322, Unite de Recherches sur les Retrovirus et Maladies; Associees, Parc Scientifique et Technologique de Luminy, Marseille,; France.; Cell adhesion molecules play an important role during immune responses. Circulating (c) forms of these molecules have been used as monitors of disease progression. In this study, we have investigated serum levels of ICAM1, ICAM2, ICAM3 and VCAM1 in HIV-infected patients. Our results showed that levels of cICAMs and cV
A 1990s perspective of hepatitis C, human immunodeficiency virus, and tuberculosis infections in dialysis patients.: Semin Nephrol. 1997 Jul;17(4):346-63. Unique Identifier : AIDSLINE MED/97385705; Murthy BV; Pereira BJ; Tufts University School of Medicine, Boston, MA, USA.; Chronic infections contribute significantly to morbidity and mortality in dialysis patients. These infections are acquired either before or after initiation of dialysis, and the latter may be via nosocomial modes of transmission. Consequently, policies that deal with infection control in dialysis units have assumed in
[Can HIV/AIDS be healed with new therapies? (editorial)]: Schweiz Rundsch Med Prax. 1997 May 28;86(22):931-2. Unique Identifier : AIDSLINE MED/97344572; Battegay M
Indication, incidence and management of blood transfusion during sinus surgery: a review over 12 years.: Rhinology. 1997 Mar;35(1):2-5. Unique Identifier : AIDSLINE MED/97343731; Maune S; Jeckstrom W; Thomsen H; Rudert H; Department of Otorhinolaryngology/Head and Neck Surgery, University of; Kiel, Germany.; The number of reports about blood transfusion-related HIV and hepatitis virus infections is increasing, presently. Thus, it should seriously be considered to inform the patient of any anticipated blood loss necessitating a transfusion of blood products. This is especially necessary for surgical procedures with only a
Cell mediated immunity to Chlamydia pneumoniae.: Scand J Infect Dis Suppl. 1997;104:18-21. Unique Identifier : AIDSLINE MED/97403750; Halme S; Surcel HM; National Public Health Institute, Oulu, Finland.; The association of Chlamydia pneumoniae to several chronic diseases such as atherosclerosis has been suggested serologically and by direct demonstration of organisms in disease lesions. Cell mediated immunity is crucial in host defense against intracellular pathogens such as C. pneumoniae. C. pneumoniae is a relativel
[Primary pulmonary hypertension. Clinical aspects, follow-up and prognostic factors]: Schweiz Med Wochenschr. 1997 May 31;127(22):923-34. Unique Identifier : AIDSLINE MED/97353981; Tillman O; Speich R; Departement Innere Medizin, Universitatsspital Zurich.; A retrospective study is presented of all patients with primary pulmonary hypertension (PPH) observed at Zurich University Hospital between 1980 and 1990. In 16 of the 36 patients (23 females/13 males, median age 40) there was a known risk factor for PPH: HIV infection (8), use of anorectic agents (7), liver cirrhosis
[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]: Schweiz Med Wochenschr. 1997 May 31;127(22):940-4. Unique Identifier : AIDSLINE MED/97353983; Eriksson U; Frick H; Medizinische Klinik, Kantonsspital Luzern.; A 33-year-old male HIV-positive patient developed pure right motor hemiplegia due to meningovascular neurosyphilis. 12 years ago he was successfully treated for early syphilis with a single dose of 2.4 million units penicillin G benzathine without subsequent evidence of new infection or disease progression. Repeated H
Novel campaign to test live HIV vaccine [news]: Science. 1997 Aug 22;277(5329):1035. Unique Identifier : AIDSLINE MED/97432996; Cohen J
Virodene--support misguided [letter]: S Afr Med J. 1997 May;87(5):613. Unique Identifier : AIDSLINE MED/97398609; Hugo BW
Virodene--support misguided [letter]: S Afr Med J. 1997 May;87(5):613. Unique Identifier : AIDSLINE MED/97398608; Spencer DC
Virodene--support misguided [letter]: S Afr Med J. 1997 May;87(5):613-4. Unique Identifier : AIDSLINE MED/97398610; Mahomed F
The 'impending' AIDS catastrophe! [letter]: S Afr Med J. 1997 May;87(5):614. Unique Identifier : AIDSLINE MED/97398611; Caldwell RI
Screening for cancer of the cervix in South Africa [letter; comment]: S Afr Med J. 1997 May;87(5):620-2. Unique Identifier : AIDSLINE MED/97398617; Sitas F; Carrara H; Terblanche M; Madhoo J
Sexual behavior risk factors associated with bacterial vaginosis and Chlamydia trachomatis infection.: Sex Transm Dis. 1997 May;24(5):241-6. Unique Identifier : AIDSLINE MED/97298282; Nilsson U; Hellberg D; Shoubnikova M; Nilsson S; M~ardh PA; Uppsala University Centre for STD Research, Sweden.; BACKGROUND AND OBJECTIVES: Few studies have demonstrated that bacterial vaginosis (BV) is associated with sexual behavior risk factors similar to those for other sexually transmitted diseases. The objective of this study was to determine the prevalence of these factors in a multivariate analysis of data from women inf
A population-based study of sexually transmitted disease incidence and risk factors in human immunodeficiency virus-infected people.: Sex Transm Dis. 1997 May;24(5):251-6. Unique Identifier : AIDSLINE MED/97298284; Belongia EA; Danila RN; Angamuthu V; Hickman CD; DeBoer JM; MacDonald KL; Osterholm MT; Minnesota Department of Health, Minneapolis 55440, USA.; BACKGROUND AND OBJECTIVES: The Minnesota Department of Health conducts active surveillance for cases of human immunodeficiency virus (HIV) infection and passive surveillance for gonorrhea, Chlamydia trachomatis infection, and syphilis. The authors linked two computerized surveillance databases to assess gonorrhea inci
Antibody to Haemophilus ducreyi among trucking company workers in Kenya.: Sex Transm Dis. 1997 May;24(5):267-71. Unique Identifier : AIDSLINE MED/97298287; Rakwar J; Jackson D; Maclean I; Obongo T; Bwayo J; Smith H; Mandaliya K; Moses S; Ndinya-Achola J; Kreiss JK; Department of Medical Microbiology, University of Nairobi, Kenya.; BACKGROUND AND OBJECTIVES: To determine the prevalence, correlates, and incidence of Haemophilus ducreyi antibodies, a cohort of East African trucking company employees was evaluated. STUDY DESIGN: Human immunodeficiency virus (HIV)-1-seronegative men working in six trucking companies in Mombasa,
Sexually transmitted diseases in men who have sex with men. Acquisition of gonorrhea and nongonococcal urethritis by fellatio and implications for STD/HIV prevention.: Sex Transm Dis. 1997 May;24(5):272-8. Unique Identifier : AIDSLINE MED/97298288; Lafferty WE; Hughes JP; Handsfield HH; Seattle-King County, Department of Public Health, University of; Washington 98195, USA.; BACKGROUND AND OBJECTIVES: Despite trends toward safer sex practices in homosexually active men, some such people remain at high risk for acquiring sexually transmitted diseases (STD). This study was designed to assess behavioral and demographic determinants of STD acquisition in men who have sex with men MSM), to gui
Safety of a nonoxynol-9 vaginal gel in Kenyan prostitutes. A randomized clinical trial.: Sex Transm Dis. 1997 May;24(5):279-83. Unique Identifier : AIDSLINE MED/97298289; Martin HL Jr; Stevens CE; Richardson BA; Rugamba D; Nyange PM; Mandaliya K; Ndinya-Achola J; Kreiss JK; Department of Medicine, University of Washington, Seattle 98104-2499,; USA.; OBJECTIVE: To evaluate the safety and toxicity of once-daily administration of Advantage-24 (Columbia Research Laboratories, Inc., Rockville Centre, NY), a vaginal gel containing 52.5 mg of nonoxynol-9 (N-9), including the effects of this gel on the vaginal and cervical epithelium. STUDY DESIGN: Randomized, placebo-co
Predictors of human immunodeficiency virus counseling and testing among sexually transmitted disease clinic patients.: Sex Transm Dis. 1997 Jul;24(6):347-52. Unique Identifier : AIDSLINE MED/97387725; Schwarcz SK; Spitters C; Ginsberg MM; Anderson L; Kellogg T; Katz MH; San Francisco Department of Public Health, Epidemiology, Disease; Control, and Aids, California 94102, USA.; OBJECTIVES: To determine the predictors of prior or current, and repeat human immunodeficiency virus (HIV) testing. STUDY DESIGN: Cross-sectional survey. METHODS: Sexually transmitted disease STD) clinic patients who participated in a blinded HIV seroprevalence survey completed a voluntary questionnaire regarding thei
Soluble P-selectin, thrombocytopenia and von Willebrand factor in HIV infected patients [letter]: Thromb Haemost. 1997 Jun;77(6):1221-2. Unique Identifier : AIDSLINE MED/97385750; Blann AD; Seigneur M; Constans J; Pellegrin JL; Conri C
Decay-accelerating factor (DAF, CD55)-negative T lymphocytes in the peripheral blood of Sjogren's syndrome patients.: Tokai J Exp Clin Med. 1996 Oct;21(3):121-8. Unique Identifier : AIDSLINE MED/97383949; Ichikawa Y; Masumoto A; Yoshida M; Yamada C; Horiki T; Hoshina Y; Uchiyama M; Takaya M; Department of Internal Medicine, School of Medicine, Tokai University,; Kanagawa, Japan.; (OBJECTIVE): To clarify possible associations of decay-accelerating factor (DAF, CD55), expressed on circulating lymphocyte subsets and other hematologic cells, with corresponding cytopenias observed in primary Sjogren s syndrome SS). (METHODS): DAF expression on peripheral blood (PB) cells was determined in 21 patien
Optimizing a limiting dilution culture system for quantifying the frequency of interleukin-2-producing alloreactive T helper lymphocytes.: Transplantation. 1997 Aug 15;64(3):472-9. Unique Identifier : AIDSLINE MED/97419039; Hornick PI; Brookes PA; Mason PD; Taylor KM; Yacoub MH; Rose ML; Batchelor R; Lechler RI; Department of Immunology, Royal Postgraduate Medical School,; Hammersmith Hospital, London, United Kingdom.; BACKGROUND: The development of sensitive, specific, and reproducible techniques to quantify T cells with direct allospecificity has potential applications in the selection of bone marrow donors and in the monitoring of the antidonor alloresponse in patients after organ transplantation. Such data may provide an objecti
Resistance to monoclonal antibody-induced CD8+ T-cell depletion in thymectomized MHC class II-deficient mice.: Transplantation. 1997 Aug 15;64(3):489-94. Unique Identifier : AIDSLINE MED/97419041; Zhao Y; Sykes M; BMT Section, Transplantation Biology Research Center, Massachusetts; General Hospital/Harvard Medical School, Boston 02129, USA.; BACKGROUND: CD8+ T cells are present at higher than normal levels in MHC class II-deficient (IIKO) mice. METHODS: In this study, we have examined the sensitivity of CD8+ T cells to depletion induced by a single injection or multiple injections of an anti-CD8 monoclonal antibody (mAb) (2.43) in IIKO mice in vivo. RESUL
Development of FIV-specific cytolytic T-lymphocyte responses in cats upon immunisation with FIV vaccines.: Vet Microbiol. 1997 Jun 30;57(1):1-11. Unique Identifier : AIDSLINE MED/97375715; Tellier MC; Soos J; Pu R; Pollock D; Yamamoto JK; Department of Pathobiology, School of Veterinary Medicine, University; of Florida, Gainesville 32611, USA.; Vaccine protection has been achieved in cats against experimental infection with feline immunodeficiency virus (FIV). Such protection has been attributed to FIV-specific humoral immunity, as well as cellular immunity of unknown mechanism(s). Since cell-mediated immunity plays a crucial role in the clearance of viral i
Longitudinal studies of immune function in cattle experimentally infected with bovine immunodeficiency-like virus and/or bovine leukemia virus.: Vet Immunol Immunopathol. 1997 May;56(1-2):27-38. Unique Identifier : AIDSLINE MED/97364300; Flaming KP; Frank DE; Carpenter S; Roth JA; Department of Microbiology, Immunology, and Preventive medicine, Iowa; State University, Ames 50011, USA.; The effects of single or dual infection with bovine immunodeficiency-like virus (BIV) and/or, bovine leukemia virus BLV) on bovine immune function were examined over a 4 year period. Holstein calves were infected with BIV (four calves), BLV five calves), BIV and BLV (five calves), or sham inoculated three calves). Lym
Bovine cytokine expression during different phases of bovine leukemia virus infection.: Vet Immunol Immunopathol. 1997 May;56(1-2):39-51. Unique Identifier : AIDSLINE MED/97364301; Keefe RG; Choi Y; Ferrick DA; Stott JL; Department of Veterinary Medicine, Pathology, Microbiology, &; Immunology, University of California at Davis 95616, USA.; rgkeefe@ucdavis.edu; The potential role of aberrant cytokine production in the pathogenesis of bovine leukemia virus (BLV) was studied by analyzing cytokine mRNA expression in pokeweed-stimulated PBMLs of cows in different phases of disease progression. To analyze the mRNA, a semi-quantitative RT-PCR assay was developed. The RT-PCR assay
Immunophenotyping of skin-infiltrating T-cell subsets in dogs with atopic dermatitis.: Vet Immunol Immunopathol. 1997 Jun;57(1-2):13-23. Unique Identifier : AIDSLINE MED/97383968; Sinke JD; Thepen T; Bihari IC; Rutten VP; Willemse T; Department of Clinical Sciences of Companion Animals, Faculty of; Veterinary Medicine, Utrecht, The Netherlands.; Atopic dermatitis in dogs has many clinical features that are identical to those of the same disorder in man. To investigate the pathogenesis of this disease in dogs and the possibility of similarities to the pathogenesis in humans we compared the presence and ratio of CD4+ and CD8+ T-cells in the cutaneous infiltrate
Mutant CD4 molecules with improved binding to HIV envelope protein gp120 selected by phage display.: Virology. 1997 Aug 4;234(2):196-202. Unique Identifier : AIDSLINE MED/97412037; Krybaev R; McKeating J; Jones I; NERC Institute of Virology, Oxford, United Kingdom.; Phage-display methodology has been used to select variant CD4 proteins exhibiting increased binding to the surface envelope glycoprotein, gp120, of Human Immunodeficiency Virus Type-1. To facilitate the selection, a library of mutant CD4 proteins was constructed by cloning a PCR-generated error prone population of the
Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity.: Virology. 1997 Aug 4;234(2):215-25. Unique Identifier : AIDSLINE MED/97412039; Miller MD; Warmerdam MT; Ferrell SS; Benitez R; Greene WC; The Gladstone Institute of Virology and Immunology, San Francisco,; California 94141, USA.; Wild-type HIV-1 is more infectious than nef-deleted HIV-1 in both limiting dilution and single-cycle infectivity assays. Moreover, Nef expression from a separate plasmid in the virus-producing cells is capable of restoring the infectivity of genetically nef-deficient HIV-1. These observations indicate that the virion
Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences.: Virology. 1997 Aug 4;234(2):253-60. Unique Identifier : AIDSLINE MED/97412043; Huffman KM; Arrigo SJ; Department of Microbiology and Immunology, Medical University of South; Carolina, Charleston 29425-2230, USA.; Human immunodeficiency virus type-1 (HIV-1) Rev overcomes negative elements within viral RNAs to allow expression of gag, pol, and env. The effect of Rev on protein and RNA expression of HIV-1 protease (PR)-containing constructs was investigated utilizing transient transfection of COS cells. Rev, through the Rev respo
Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds.: Virology. 1997 Aug 4;234(2):277-90. Unique Identifier : AIDSLINE MED/97412046; Lee R; Beauparlant P; Elford H; Ponka P; Hiscott J; Lady Davis Institute for Medical Research, Department of Microbiology,; McGill University, Montreal, Quebec, Canada.; Oxidative stress activates the NF-kappaB/Rel transcription factors which are involved in the activation of numerous immunoregulatory genes and the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). In the present study, we examined the effects of established and novel compounds including antioxida
Infected macaques that controlled replication of SIVmac or nonpathogenic SHIV developed sterilizing resistance against pathogenic SHIV(KU-1).: Virology. 1997 Aug 4;234(2):328-39. Unique Identifier : AIDSLINE MED/97412052; Stephens EB; Joag SV; Atkinson B; Sahni M; Li Z; Foresman L; Adany I; Narayan O; Department of Microbiology, Molecular Genetics, and Immunology,; University of Kansas Medical Center, Kansas City 66160-7240, USA.; estephen@kumc.edu; Twenty macaques were used to evaluate the ability of nonpathogenic SIV(mac) or nonpathogenic chimeric SIV-HIV (SHIV) to induce protection in macaques against superinfection with a pathogenic variant of SHIV (SHIV(KU-1)) originally containing the tat, rev, vpu, and env of HIV-1 (strain HXB2) in a genetic background of
Contribution to the regulation of virus replication in cells latently infected with human immunodeficiency virus 1.: Acta Virol. 1997 Feb;41(1):21-6. Unique Identifier : AIDSLINE MED/97343081; Owatari S; Zhang J; Gao M; Tanabe-Tochikura A; Wakamiya N; Tsuchie H; Kurimura T; Department of Viral Infections, Osaka University, Japan.; Monocytes/macrophages have been known to play an important role in the initiation and propagation of human immunodeficiency virus 1 (HIV-1) infection. To analyze the function of these cells during the clinical asymptomatic period of infection, we examined the effect of murine peritoneal macrophages and human periphera
Phylogenetic analysis of human immunodeficiency virus 1 in Ghana.: Acta Virol. 1997 Feb;41(1):51-4. Unique Identifier : AIDSLINE MED/97343087; Takehisa J; Osei-Kwasi M; Ayisi NK; Hishida O; Miura T; Igarashi T; Brandful J; Ampofo W; Netty VB; Mensah M; Yamashita M; Ido E; Hayami M; Laboratory of Pathogenic Virus, Kyoto University, Japan.; Eleven human immunodeficiency virus 1 (HIV-1) isolates from Ghanaian acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) patients obtained by our serosurvey in 1986-1994 were genomically analyzed and phylogenetically compared with other known strains. A phylogenetic tree constructed by analyzing th
Human immunodeficiency virus infection and nutritional status in female drug addicts undergoing detoxification: anthropometric and immunologic assessments.: Am J Clin Nutr. 1997 Aug;66(2):504S-508S. Unique Identifier : AIDSLINE MED/97393702; Varela P; Marcos A; Santacruz I; Ripoll S; Requejo AM; Instituto de Nutricion y Bromatologia [Consejo Superior de; Investigaciones Cientificas (CSIC)], Universidad Complutense de Madrid; (UCM), Spain.; To clarify the interrelations among drug abuse, malnutrition, and immunosuppression, the effects of human immunodeficiency virus HIV) infection on the nutritional status of 17 noninfected and 19 HIV-infected asymptomatic female drug addicts undergoing detoxification were evaluated by measuring anthropometric and immun
Effects of human immunodeficiency virus infection and detoxification time on anthropometric measurements and dietary intake of male drug addicts.: Am J Clin Nutr. 1997 Aug;66(2):509S-514S. Unique Identifier : AIDSLINE MED/97393703; Varela P; Marcos A; Ripoll S; Santacruz I; Requejo AM; Instituto de Nutricion y Bromatologia [Consejo Superior de; Investigaciones Cientificas (CSIC)], Universidad Complutense de Madrid; (UCM), Spain.; Anthropometric measurements and dietary intakes of male drug addicts (n = 62), infected (n = 23) or not infected (n = 39) with human immunodeficiency virus (HIV), who underwent two phases of detoxification (P1:15 d to 1 mo and P2: 5-6 mo) were assessed. Body weight, weight gain during detoxification, height, body mass
Heterosexual transmission of human immunodeficiency virus (HIV) in northern California: results from a ten-year study.: Am J Epidemiol. 1997 Aug 15;146(4):350-7. Unique Identifier : AIDSLINE MED/97416464; Padian NS; Shiboski SC; Glass SO; Vittinghoff E; Department of Obstetrics, Gynecology and Reproductive Sciences,; University of California, San Francisco, USA.; To examine rates of and risk factors for heterosexual transmission of human immunodeficiency virus (HIV), the authors conducted a prospective study of infected individuals and their heterosexual partners who have been recruited since 1985. Participants were recruited from health care providers, research studies, and h
Re: "Cryptosporidiosis among patients infected with human immunodeficiency virus: factors related to symptomatic infection and survival" [letter; comment]: Am J Epidemiol. 1997 Aug 15;146(4):358-9. Unique Identifier : AIDSLINE MED/97416465; Clark RA; Bessinger R
Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group [see comments]: Am J Ophthalmol. 1997 Aug;124(2):141-57. Unique Identifier : AIDSLINE MED/97408018; PURPOSE: To examine associations of systemic and ocular characteristics with severity of cytomegalovirus ( CMV ) retinitis at time of diagnosis and to compare ocular characteristics of eyes with and without CMV retinitis. METHO
Analysis of visual dysfunctions in HIV-positive patients without retinitis [see comments]: Am J Ophthalmol. 1997 Aug;124(2):158-67. Unique Identifier : AIDSLINE MED/97408019; Mueller AJ; Plummer DJ; Dua R; Taskintuna I; Sample PA; Grant I; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California San Diego, La Jolla, California 92093-0946, USA.; PURPOSE: To investigate visual dysfunctions in ophthalmoscopically normal human immunodeficiency virus HIV)-positive patients and to correlate the results to the stage of HIV disease and neuropsychological status. METHODS: Fifty-one randomly selected eyes (26 right, 25 left) of 51 HIV-positive patients with visual acu
Intraocular pressure and aqueous humor dynamics in patients with AIDS treated with intravitreal cidofovir (HPMPC) for cytomegalovirus retinitis [see comments]: Am J Ophthalmol. 1997 Aug;124(2):168-80. Unique Identifier : AIDSLINE MED/97408020; Banker AS; Arevalo JF; Munguia D; Rahhal FM; Ishimoto B; Berry C; De Clercq E; Ochabski R; Taskintuna I; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California, San Diego, La Jolla 92093-0946, USA.; PURPOSE: To evaluate the decrease in intraocular pressure associated with cidofovir 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate; HPMPC) intravitreal injections. METHODS: We followed up 97 eyes of 63 patients with acquired immunodeficiency syndrome (AIDS) who had cyto
An in vivo model of human cytomegalovirus retinal infection.: Am J Ophthalmol. 1997 Aug;124(2):181-9. Unique Identifier : AIDSLINE MED/97408021; Laycock KA; Fenoglio ED; Hook KK; Pepose JS; Department of Ophthalmology and Visual Sciences, Washington University; School of Medicine, St Louis, Missouri 63110, USA.; PURPOSE: To develop an animal model system in which human retina implanted in the anterior chamber of the eyes of rats would support human cytomegalovirus replication. Cytomegalovirus retinitis currently represents the most common cause of posterior uveitis in many urban areas in N
Elevation of laser flare photometry in patients with cytomegalovirus retinitis and AIDS [see comments]: Am J Ophthalmol. 1997 Aug;124(2):190-8. Unique Identifier : AIDSLINE MED/97408022; Magone MT; Nussenblatt RB; Whitcup SM; Clinical Branch, National Eye Institute, National Institutes of; Health, Bethesda, Maryland, USA.; PURPOSE: To investigate an alteration of the blood-ocular barriers by laser flare photometry in patients with acquired immunodeficiency syndrome (AIDS) diagnosed with cytomegalovirus retinitis. METHODS: Serial laser flare photometry measurements from 31 eyes of 31 patients with AID
Regression of cytomegalovirus retinitis associated with protease-inhibitor treatment in patients with AIDS [see comments]: Am J Ophthalmol. 1997 Aug;124(2):199-205. Unique Identifier : AIDSLINE MED/97408023; Reed JB; Schwab IR; Gordon J; Morse LS; Department of Ophthalmology, University of California, Davis,; Sacramento 95816, USA.; PURPOSE: To report the observation that anti-retroviral therapy that includes a protease inhibitor can induce the regression of cytomegalovirus retinitis without requiring specific anticytomegalovirus drug therapy. METHODS: We examined the fundi of four patients with advanced acqui
Lack of virus transmission by the excimer laser plume.: Am J Ophthalmol. 1997 Aug;124(2):206-11. Unique Identifier : AIDSLINE MED/97408024; Hagen KB; Kettering JD; Aprecio RM; Beltran F; Maloney RK; Loma Linda University School of Medicine, California, USA.; PURPOSE: To test the possibility of pathogenic virus transmission into the operating suite during excimer laser treatment of corneal tissue. Such treatment vaporizes corneal tissue, which may put the surgeon at risk of infection from human immunodeficiency virus, hepatitis virus, or other viruses. We developed a model
AIDS and ophthalmology: a period of transition [editorial; comment]: Am J Ophthalmol. 1997 Aug;124(2):227-33. Unique Identifier : AIDSLINE MED/97408028; Jabs DA; Bartlett JG
Antiviral chemoprophylaxis after occupational exposure to human immunodeficiency virus: why, when, where, and what [see comments]: Am J Ophthalmol. 1997 Aug;124(2):234-9. Unique Identifier : AIDSLINE MED/97408029; Landers MB 3rd; Fraser VJ; Eastern Virginia Medical School, Retina and Vitreous Center, Virginia; Beach 23454, USA. reecelanders@webtv.net; PURPOSE: To update ophthalmologists on recent developments in the area of antiviral chemoprophylaxis after occupational exposure to human immunodeficiency virus (HIV). Background information is provided by which to make an informed decision about whether to initiate antiviral chemoprophylaxis against HIV infection. ME
Molluscum contagiosum eyelid lesions as the initial manifestation of acquired immunodeficiency syndrome.: Am J Ophthalmol. 1997 Aug;124(2):240-1. Unique Identifier : AIDSLINE MED/97408030; Leahey AB; Shane JJ; Listhaus A; Trachtman M; Department of Surgery, Lehigh Valley Hospital, Allentown, PA, USA.; PURPOSE: To report molluscum contagiosum as the initial manifestation in acquired immunodeficiency syndrome (AIDS). METHOD: Case report. A 34-year-old man was examined with atypical, extensive molluscum contagiosum of the eyelids. RESULTS: Biopsy of the lesions confirmed molluscum contagiosum, and a previously normal
Ocular and sinus microsporidial infection cured with systemic albendazole.: Am J Ophthalmol. 1997 Aug;124(2):241-3. Unique Identifier : AIDSLINE MED/97408031; Gritz DC; Holsclaw DS; Neger RE; Whitcher JP Jr; Margolis TP; Francis I. Proctor Foundation for Research in Vision and; Ophthalmology, King Khaled Eye Specialist Hospital, Kingdom of Saudi; Arabia. gritz@compuserve.com; PURPOSE: To report treatment of a patient with acquired immunodeficiency syndrome (AIDS) and ocular and paranasal sinus microsporidial infection. METHOD: Case report. RESULTS: A patient with AIDS and ocular microsporidial infection experienced resolution of ocular symptoms with topical fumagillin, but symptoms recurre
Peroxynitrite-mediated nitration of peptides: characterization of the products by electrospray and combined gas chromatography-mass spectrometry.: Arch Biochem Biophys. 1997 Aug 15;344(2):253-9. Unique Identifier : AIDSLINE MED/97407788; Yi D; Smythe GA; Blount BC; Duncan MW; Biomedical Mass Spectrometry Unit, University of New South Wales,; Sydney, Australia.; Peroxynitrite (ONOO-) can react with a wide range of biomolecules resulting in peroxidation, oxidation, and/or nitration and as a consequence cause their inactivation. In this study mass spectrometry (MS) combined with both liquid (LC) and gas chromatography (GC) has been employed to identify the products formed follo
Diagnosis of primary human herpesvirus 6 and 7 infections in febrile infants by polymerase chain reaction.: Arch Dis Child. 1997 Jul;77(1):42-5. Unique Identifier : AIDSLINE MED/97425100; Clark DA; Kidd IM; Collingham KE; Tarlow M; Ayeni T; Riordan A; Griffiths PD; Emery VC; Pillay D; Department of Virology, Royal Free Hospital School of Medicine,; London.; Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis was based on the differential detection of viral DNA in peripheral blood mononuclear cells (PBMC), but not in saliva. Six of 41 febrile infa
Acquired rectovaginal fistulae in South Africa [letter]: Arch Dis Child. 1997 Jul;77(1):94. Unique Identifier : AIDSLINE MED/97425123; Banieghbal B; Fonseca J
A sensitive PCR assay system for the quantitation of viral genome equivalents: human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV).: Arch Virol. 1997;142(7):1297-306. Unique Identifier : AIDSLINE MED/97412801; Hammerle T; Himmelspach M; Dorner F; Falkner FG; Immuno AG, Biomedical Research Center, Orth/Donau, Austria.; A sensitive and reliable quantitative method based on the polymerase chain reaction (PCR) and the reverse transcription polymerase chain reaction (RT-PCR) to detect and quantify human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV), respectively, was developed. The samples are co-processed together with two
Human T-lymphotropic virus type II infection in Vietnamese thalassemic patients.: Arch Virol. 1997;142(7):1429-40. Unique Identifier : AIDSLINE MED/97412810; Lin MT; Nguyen BT; Binh TV; Be TV; Chiang TY; Tseng LH; Yang YC; Lin KH; Chen YC; Department of Oncology, Blood Transfusion Hematology Center, Ho Chi; Minh City, Vietnam.; Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vie
Phylogenetic analysis of feline immunodeficiency virus isolated from cats in Taiwan.: Arch Virol. 1997;142(7):1459-67. Unique Identifier : AIDSLINE MED/97412812; Inada G; Miyazawa T; Inoshima Y; Kohmoto M; Ikeda Y; Liu CH; Lin JA; Kuo TF; Mikami T; Department of Veterinary Microbiology, Faculty of Agriculture,; University of Tokyo, Japan.; Feline immunodeficiency virus was isolated from four cats in Taiwan . The isolates were designated TI-1, TI-2, TI-3 and TI-4. Each was isolated from PBMCs following co-cultivation of PBMCs with a feline T-lymphoblastoid cell line (MY
Liaison psychiatry in an HIV/AIDS unit.: Aust N Z J Psychiatry. 1997 Jun;31(3):391-7. Unique Identifier : AIDSLINE MED/97369626; Judd FK; Cockram A; Mijch A; McKenzie D; Department of Psychiatry, University of Melbourne, Royal Melbourne; Hospital, Parkville, Victoria, Australia.; OBJECTIVE: To provide an overview of the work of a liaison psychiatry service to an HIV/AIDS inpatient unit, and particularly to examine the identification of mood and related disorders by referring doctors. METHOD: The MICRO-CARES prospective clinical database system was used to obtain data on all patients referred t
Evaluating AIDS-related social skills in Anglo and Latino adolescents. Focus on assessment.: Behav Modif. 1997 Jul;21(3):281-307. Unique Identifier : AIDSLINE MED/97388067; Blumberg EJ; Hovell MF; Werner CA; Kelley NJ; Sipan CL; Burkham SM; Hofstetter CR; San Diego State University, USA.; The purpose of this study was to examine the assessment of AIDS-related social skills (measured by role play) in Anglo and Latino adolescents (N = 383) and to explore ethnic and gender differences on these skills. Eight skills were assessed on five measures evaluating molar, molecular, verbal, and nonverbal dimensions
The D1-A2 and D2-A2 pairs of splice sites from human immunodeficiency virus type 1 are highly efficient in vitro, in spite of an unusual branch site.: Biochem Biophys Res Commun. 1997 Aug 8;237(1):182-7. Unique Identifier : AIDSLINE MED/97410139; Damier L; Domenjoud L; Branlant C; Laboratoire d'Enzymologie et de Genie Genetique, URA CNRS 457,; Universite Henri Poincare Nancy 1, Vandoeuvre les Nancy, France.; Using in vitro splicing assays with HeLa cell nuclear extracts, we showed that the HIV-1 pairs of splice sites D1-A2 and D2-A2 are efficiently used in vitro, as compared to the control D1-A2 pair of sites from the E3 transcription unit of human adenovirus-2. The strong efficiency of the two HIV-1 pairs of sites is sur
Effect of 2',3'-dideoxycytidine on oxidative phosphorylation in the PC12 cell, a neuronal model.: Biochem Pharmacol. 1997 May 15;53(10):1485-92. Unique Identifier : AIDSLINE MED/97405832; Keilbaugh SA; Hobbs GA; Simpson MV; Department of Biochemistry and Cell Biology, State University of New; York, Stony Brook 11794, U.S.A.; Peripheral neuropathy induced by 2 ,3 -dideoxycytidine ( ddC ) could result from the previously shown inhibition of mtDNA replication by the action of ddC on the mitochondrial enzyme DNA polymerase gamma. Such inhibition would be expected to impair oxid
Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells.: Biochem Pharmacol. 1997 Jun 1;53(11):1719-24. Unique Identifier : AIDSLINE MED/97407576; Parsons PG; Hansen C; Fairlie DP; West ML; Danoy PA; Sturm RA; Dunn IS; Pedley J; Ablett EM; Queensland Cancer Fund Laboratories, Queensland Institute of Medical; Research, Herston, Australia.; Azelaic bishydroxamic acid (ABHA), a potent differentiating agent for lymphoid cells, was selectively toxic for 5 human tumor cell lines and transformed human melanocytes and keratinocytes (dose for 37% survival, D37, 30-100 microg/mL) compared with normal cells (melanocytes, fibroblasts; D37 > 300 microg/mL). Dendrit
[Unusual vascular lesions in the course of a colonic leishmaniasis in an HIV positive patient]: Ann Pathol. 1997 Jul;17(3):200-2. Unique Identifier : AIDSLINE MED/97410968; Lemaistre AI; Chapel F; Cie P; Jeantils V; Guettier C; Service d'Anatomie Pathologique, Hopital Jean Verdier, Bondy.; Patients with acquired immunodeficiency syndrome are often susceptible to atypical dissemination of visceral leishmaniasis. Digestive localizations seem to be relatively frequent. Colonic localizations reported in the literature are endoscopically normal or show superficial mucosal lesions. We describe an original cas
The latency rate of human herpesvirus 6 (HHV6) in positive and negative human immunodeficiency virus (HIV) infection of intravenous drug users (IVDU).: Asian Pac J Allergy Immunol. 1997 Mar;15(1):29-33. Unique Identifier : AIDSLINE MED/97395745; Jayavasu C; Balachandra K; Wongchuree S; Kositanont U; Warachit P; National Institute of Health, Department of Medical Sciences, Ministry; of Public Health, Thailand.; The seropositive and latency rates of HHV6 among IVDU with positive and negative HIV and control group were demonstrated. By immunofluorescent antibody test, no differences in the seropositive rates were found among these three groups. All groups had seropositive rate at the average 89% and GMT antibody 1:26. This mea
International clinical trials of HIV vaccines: I. Phase I trial of an HIV-1 synthetic peptide vaccine in Bangkok, Thailand.: Asian Pac J Allergy Immunol. 1997 Mar;15(1):41-8. Unique Identifier : AIDSLINE MED/97395747; Phanuphak P; Teeratakulpixarn S; Sarangbin S; Nookhai S; Ubolyam S; Sirivichayakul S; Leesavan A; Forrest BD; Hanson CV; Li M; Wang CY; Koff WC; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; A randomized, double blind, placebo controlled Phase I trial of a prototype human immunodeficiency virus type 1 (HIV-1) synthetic peptide vaccine was conducted in Bangkok, Thailand , to evaluate the safety and immunogenicity of the vaccine in a population of healthy adults at low
Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2-[aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity [published erratum appears in Farmaco 1997 May;52(5):353-4]: Farmaco. 1997 Mar;52(3):157-66. Unique Identifier : AIDSLINE MED/97355969; Loriga M; Piras S; Sanna P; Paglietti G; Istituto di Chimica Farmaceutica, Universita di Sassari.; Thirty-three quinoxalines bearing an aminobenzoyl or aminobenzoylglutamate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to stron
Acyclic glycosidopyrroles analogues of ganciclovir: synthesis and biological activity.: Farmaco. 1997 May;52(5):281-2. Unique Identifier : AIDSLINE MED/97419483; Diana P; Barraja P; Almerico AM; Dattolo G; Mingoia F; Loi AG; Congeddu E; Musiu C; Putzolu M; La Colla P; Istituto Farmacochimico, Universita degli Studi, Palermo, Italy.; Acyclic glycosidopyrroles of type 3 were synthetized in good overall yields, according to the Scheme. When evaluated for antiviral activity against DNA and RNA viruses, only compound in which R1 = R2 = Ph, R3 = NH2 was found to inhibit the HIV-1 replication at concentrations that were not cytotoxic for MT-4 cells.
Sulfone derivatives with anti-HIV activity.: Farmaco. 1997 May;52(5):323-9. Unique Identifier : AIDSLINE MED/97419488; Silvestri R; Artico M; Massa S; Stefancich G; Congeddu E; Putzolu M; La Colla P; Dipartimento di Studi Farmaceutici, Universita di Roma La Sapienza,; Italy.; Following the discovery of anti-HIV properties of suramin great efforts were devoted to design novel NNRT agents with the aims to find novel drugs for the clinical therapeutic management of AIDS. Sulfone and sulfonamide derivatives were studied by NCI at Bethesda as potential anti-HIV-1 agents and nitrophenyl phenyl s
Activated naive and memory CD4+ and CD8+ subsets in different stages of HIV infection.: Pathobiology. 1997;65(2):91-9. Unique Identifier : AIDSLINE MED/97396881; Ginaldi L; De Martinis M; D'Ostilio A; Di Gennaro A; Marini L; Profeta V; Quaglino D; Department of Internal Medicine, University of L'Aquila, Italy.; The aim of this study was to evaluate the changes and the correlations between the main lymphoid phenotypes indicative of activation and/or functional states during the course of HIV infection. Immunophenotype studies by flow cytometry were performed on blood samples from 59 HIV-1-positive patients, divided into four
Type 1 and type 2 cytokines in HIV infection -- a possible role in apoptosis and disease progression [editorial]: Ann Med. 1997 Jun;29(3):185-8. Unique Identifier : AIDSLINE MED/97382618; Clerici M; Fusi ML; Ruzzante S; Piconi S; Biasin M; Arienti D; Trabattoni D; Villa ML; The progression of HIV-infected subjects to AIDS was recently postulated to be controlled by the balance between type 1 cytokines (mainly enhancing cell-mediated immunity) and type 2 cytokines (mainly augmenting antibody production). Thus, progression of HIV infection was suggested to be accompanied by a decline of in
Quarterly communicable disease review. October to December 1996. From the PHLS Communicable Disease Surveillance Centre.: J Public Health Med. 1997 Jun;19(2):233-8. Unique Identifier : AIDSLINE MED/97387409; Adak GK; Evans B; Gill ON; Hawker J
Ethnic differences in the association between behavior with a new partner: an event-based analysis.: AIDS Educ Prev. 1997 Jun;9(3):219-37. Unique Identifier : AIDSLINE MED/97385375; Graves KL; Hines AM; Alcohol Research Group, Western Consortium for Public Health,; Berkeley, CA 94709, USA.; The relationship of alcohol consumption to risky sexual behavior at the most recent encounter with a new sexual partner in representative samples of white, Hispanic, and black adults was examined. Drinking at the new partner event was more prevalent among whites than either blacks or Hispanics. Multivariate analyses i
Assessing the impact of HIV risk reduction counseling in impoverished African American women: a structural equations approach.: AIDS Educ Prev. 1997 Jun;9(3):253-73. Unique Identifier : AIDSLINE MED/97385377; Nyamathi AM; Stein JA; University of California, Los Angeles, School of Nursing, Center for; Health Sciences 90024, USA.; We assessed changes in cognitive, psychological, and risky behavior latent variables after traditional or specialized AIDS education after 2 years using structural equation modeling (SEM) in a sample of impoverished at-risk African American women (N = 300). Both groups reported significant improvement at 2 years in th
The role of psychosocial assessment and support in occupational exposure management.: AIDS Educ Prev. 1997 Jun;9(3):275-84. Unique Identifier : AIDSLINE MED/97385378; Tannebaum J; Anastasoff J; Department of Social Work, Thomas Jefferson University Hospital,; Philadelphia, PA 19107, USA.; Hundreds of thousands of occupational exposures to the blood and body fluids of patients occur every year in health care settings. The risk of acquiring HIV infection after exposure to HIV infected blood is 0.452%. Despite this low risk, the impact of each of these exposures is significant to the health care worker wh
Children's AIDS-related knowledge and attitudes: variations by grade, race, gender, socioeconomic status, and size of community.: AIDS Educ Prev. 1997 Jun;9(3):285-98. Unique Identifier : AIDSLINE MED/97385379; Kistner J; Eberstein IW; Quadagno D; Sly D; Sittig L; Foster K; Balthazor M; Castro R; Osborne M; Psychology Department, Florida State University, Tallahassee; 32306-4063, USA.; Variations of AIDS-related beliefs by grade, race, gender, socioeconomic status, and size of the community were examined for a diverse group of elementary school children (n = 609). Consistent with prior research, beliefs about HIV transmission and willingness to interact with persons with AIDS increased across grades
The evaluation of HIV counseling-and-testing services: making the most of limited resources.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):105-18. Unique Identifier : AIDSLINE MED/97385388; Holtgrave DR; Reiser WJ; Di Franceisco W; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, Milwaukee 53202, USA. holtgrav@post.its.mcw.edu; The evaluation of HIV counseling, testing, referral, and partner notification (CTRPN) services are especially important given the rapid, relevant changes in counseling strategies, public policies, and testing technologies. Here we briefly review the important components of a comprehensive HIV CTRPN evaluation. However
Concepts, goals, and techniques of counseling: review and implications for HIV counseling and testing.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):14-26. Unique Identifier : AIDSLINE MED/97385381; Sikkema KJ; Bissett RT; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53202, USA.; Research to examine, understand, and improve the usefulness and effectiveness of HIV counseling and testing (HIV CT) has been challenging, to some extent because of a less than fully articulated conceptual framework. The goal of this article is to place HIV CT in a conceptual and theoretical context, not only of couns
HIV counseling and testing: its evolving role in HIV prevention.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):2-13. Unique Identifier : AIDSLINE MED/97385380; Valdiserri RO; National Center for HIV, STD, and TB Prevention, Centers for Disease; Control and Prevention.; The development of an enzyme-linked immunosorbent assay (ELISA) for screening blood for antibodies to HIV was a major milestone in the history of AIDS prevention and treatment. Since early 1985, the Centers for Disease Control and Prevention (CDC) has provided public funds to state and local health departments to supp
Advances in HIV testing technology and their potential impact on prevention.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):27-40. Unique Identifier : AIDSLINE MED/97385382; Kassler WJ; Health Services Research and Evaluation Branch, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA.; Recent advances in HIV testing technology are increasing options for HIV testing which may lead to more persons at risk for HIV infection learning their serostatus. These advances include the development of simple rapid assays with visual reading, several of which can be used with whole blood (including finger stick)
It's like a regular part of gay life: repeat HIV antibody testing among gay and bisexual men.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):41-51. Unique Identifier : AIDSLINE MED/97385383; Kalichman SC; Schaper PE; Belcher L; Abush-Kirsh T; Cherry C; Williams EA; Nachimson D; Smith S; Psychology Department, Georgia State University, Atlanta 30303, USA.; psysck@panther.gsu.edu; HIV antibody testing is a critical facet of national AIDS prevention strategies and increasing numbers of persons are tested each year. Research has shown that a significant number of men who have sex with men are repeatedly tested for HIV antibodies, and many are tested regularly every 6 months. This study investigat
The effects of HIV counseling and testing on risk-related practices and help-seeking behavior.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):52-67. Unique Identifier : AIDSLINE MED/97385384; Wolitski RJ; MacGowan RJ; Higgins DL; Jorgensen CM; Behavioral Intervention Research Branch, Centers for Disease Control; and Prevention, Atlanta, GA 30333, USA. ryw1@cdc.gov; In an earlier review of the behavioral effects of HIV counseling and testing (HIV CT), Higgins and colleagues (1991) found that the evidence regarding the ability of HIV CT to influence HIV-risk related practices was largely inconclusive. This article reviews 35 domestic and international studies published since that
Partner notification for HIV prevention: a critical reexamination.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):68-78. Unique Identifier : AIDSLINE MED/97385385; West GR; Stark KA; Division of HIV/AIDS Prevention-Intervention Research and Support,; Centers for Disease Control and Prevention, Atlanta, GA.; The history, current role, and potential enhanced functions of HIV partner notification are reviewed. What is known about the effectiveness of partner notification is summarized and five general findings are reported: (1) many, if not most, HIV-infected individuals will cooperate in notifying at least some of their se
Publicly funded HIV counseling and testing in the United States, 1992-1995.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):79-91. Unique Identifier : AIDSLINE MED/97385386; Weber JT; Frey RL Jr; Horsley R; Gwinn ML; Prevention Services Research Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA. jtw5@.cdc.gov; Data are collected and reported through the Centers for Disease Control and Prevention (CDC) Counseling and Testing System (CTS) on episodes of publicly funded counseling and HIV testing in the Unites States. The objective of this analysis is to describe testing data reported from 1992 through 1995. In 1992, 2,689,056
The role of HIV counseling and testing in the developing world.: AIDS Educ Prev. 1997 Jun;9(3 Suppl):92-104. Unique Identifier : AIDSLINE MED/97385387; Campbell CH Jr; Marum ME; Alwano-Edyegu M; Dillon BA; Moore M; Gumisiriza E; Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.; The role of voluntary HIV counseling and testing is still under debate, especially in the developing world. HIV counseling-and-testing (HIV CT) services are a major component of HIV and AIDS control programs in the industrialized world and are increasingly being advocated in the developing world. In the
Natural antibodies to IL-2.: Biotherapy. 1997;10(1):25-8. Unique Identifier : AIDSLINE MED/97404853; Balsari A; Caruso A; Chair of Immunology, School of Medicine, University of Milan, Italy.; Natural antibodies to human interleukin-2 are present in sera of patients infected with human immunodeficiency virus and also, at a lower titre, in sera of healthy individuals. These antibodies could be purified by affinity-chromatography. Purified human anti-hIL-2 antibodies can interfere with lymphocyte proliferatio
CD3+ CD8+ CD56- clonal large granular lymphocyte leukaemia and HIV infection.: Br J Haematol. 1997 Aug;98(2):444-5. Unique Identifier : AIDSLINE MED/97410232; Pulik M; Lionnet F; Genet P; Petitdidier C; Jary L; Fourcade C; Department of Haematology, Argenteuil, France.; High-grade malignant lymphomas associated with HIV infection are usually derived from B lymphocytes. Although a broad spectrum of T-cell-derived malignancies has been described, no case of monoclonal T large granular lymphocyte leukaemia has been reported to date. We report a case of clonal T-LGL (CD3+, CD4-, CD8+, CD
Apoptosis in AIDS.: Adv Pharmacol. 1997;41:271-94. Unique Identifier : AIDSLINE MED/97348082; Badley AD; Dockrell D; Paya CV; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota; 55905, USA.
HIV-1 and HIV-2 in Ghana, west Africa: community surveys compared to surveys of pregnant women.: West Afr J Med. 1997 May-Jun;16(2):102-8. Unique Identifier : AIDSLINE MED/97401912; Neequaye AR; Neequaye JE; Biggar RJ; Mingle JA; Drummond J; Waters D; UGMS Accra Ghana.; We conducted a population-based serosurvey of HIV-1/2 in 2,410 residents of two urban and two rural areas of southern Ghana , West Africa and compared the results to serosurveys of 1,417 pregnant women. Using conservative criteria, we found the prevalence of HIV-1/2 in community surv
Differentiation of dual seropositivity to HIV 1 and HIV 2 in Ghanaian sera using line immunoassay (INNOLIA).: West Afr J Med. 1997 May-Jun;16(2):71-4. Unique Identifier : AIDSLINE MED/97401905; Mingle JA; Department of Microbiology University of Ghana Medical School Acrra,; Ghana.; Two hundred serum samples from AIDS-like patients, blood donors and miscellaneous patients were screened by ELISA for HIV 1-2. Repeatedly positive samples were confirmed using the Western Blot WB). Twenty samples that were dual positive were further analysed by Innolia, which contains synthetic or recombinant antigens
Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.: Biochemistry. 1997 Aug 19;36(33):10292-300. Unique Identifier : AIDSLINE MED/97400489; Krebs R; Immendorfer U; Thrall SH; Wohrl BM; Goody RS; Max Planck Institut fur molekulare Physiologie, Abteilung; Physikalische Biochemie, Rheinlanddamm 201, D-44139 Dortmund, Germany.; Two mutants of HIV-1 reverse transcriptase (RT) associated with high-level resistance of the virus to AZT (RT-AZT: D67N, K70R, T215Y, K219Q, and M41L) or 3-TC (RT- 3TC : M184V) were exp
Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking.: Biochemistry. 1997 Sep 2;36(35):10655-65. Unique Identifier : AIDSLINE MED/97419129; Heuer TS; Brown PO; Department of Biochemistry, Program in Cancer Biology, Stanford; University Medical Center, California 94305-5428, USA.; The virally encoded integrase protein carries out retroviral integration, and to do so, it must make specific interactions with both viral and target DNA sequences. The retroviral integrase has three domains: an amino-terminal region of about 50 amino acids that contains a zinc finger-like motif, a tightly folded, phy
Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.: Biochemistry. 1997 Sep 2;36(35):10696-708. Unique Identifier : AIDSLINE MED/97419133; Laco GS; Schalk-Hihi C; Lubkowski J; Morris G; Zdanov A; Olson A; Elder JH; Wlodawer A; Gustchina A; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702, USA.; Crystal structures of complexes of a D30N mutant of feline immunodeficiency virus protease (FIV PR) complexed with a statine-based inhibitor (LP-149), as well as with a substrate based on a modification of this inhibitor (LP-149S), have been solved and refined at resolutions of 2.0 and 1.85 A, respectively. Both the i
New insights and interventions: churches uniting to reach the African American community with health information.: J Health Care Poor Underserved. 1997 Aug;8(3):373-5; discussion 375-6. Unique Identifier : AIDSLINE MED/97397103; Sanders EC 2nd; Metropolitan Interdenominational Church, Nashville, TN 37208, USA.; Effective church-based community health programs must take a holistic approach when dealing with health problems among African Americans. Such an approach emphasizes the relationship between the physiological, psychological, and spiritual selves. These programs must also ensure the complete involvement of clergy and c
[Attitudes of nursing staff in Western Malaga to HIV/AIDS infection]: Aten Primaria. 1997 Jun 30;20(2):65-70. Unique Identifier : AIDSLINE MED/97401773; Molina Cabrillana J; Fernandez Nebreda R; Hernandez Perez-Lanzac C; Sanchez-Cantalejo E; Hospital Clinico Universitario Servicio de Medicina Preventiva; Malaga).; OBJECTIVES: To identify how nursing staff at two care levels in the western area of Malaga view Human immunodeficiency Virus infection (HIV/AIDS), evaluating differences that might exist in function of age, sex, professional status, work seniority, contact with infected people, perceived risk, information received and
Bacteremia caused by Helicobacter cinaedi in an AIDS patients.: J Formos Med Assoc. 1997 Jul;96(7):558-60. Unique Identifier : AIDSLINE MED/97405420; Hung CC; Hsueh PR; Chen MY; Teng LJ; Chen YC; Luh KT; Chuang CY; Department of Internal Medicine, National Taiwan University Hospital,; Taipei, ROC.; Helicobacter cinaedi bacteremia has been infrequently described in homosexual patients with HIV infection. It may recur despite appropriate antimicrobial therapy. We report a bisexual patient with AIDS in whom H. cinaedi bacteremia developed and presented with prolonged fever and chronic diarrhea. The symptoms resolve
The influence of birthplace on mortality among Hispanic residents of New York City.: Ethn Dis. 1997 Winter;7(1):55-64. Unique Identifier : AIDSLINE MED/97397517; Fang J; Madhavan S; Alderman MH; Department of Epidemiology and Social Medicine, Albert Einstein; College of Medicine, New York 10461, USA. fang@aecom.yu.edu; To determine the mortality experience of Hispanic residents of New York City and the influence of birthplace on their mortality rates, NYC Department of Health mortality records for 1988 to 1992 were linked for analysis with 1990 United States census data for New York City. Age-specifi
IL-4 as a key factor influencing the development of allergen-specific Th2-like cells in atopic individuals.: J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):144-50. Unique Identifier : AIDSLINE MED/97396707; Ricci M; Matucci A; Rossi O; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy.; In the last years Th2-like cells, able to produce IL-4, IL-5, IL-6 and IL-10, have been shown to play an important role in the pathogenesis of allergic diseases. They are absolutely required for IgE production by B-cells and are expanded at the level of target tissues of atopic patients. Very recently, much attention
Comparison among delayed-type skin tests, serum IgE levels and peripheral blood CD4 in HIV-positive patients.: J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):183-5. Unique Identifier : AIDSLINE MED/97396714; Alonso A; Coduri CL; Bignone ML; Pionetti CH; Centro de Alergia, Hospital de Clinicas, Departamento de; Microbiologia, Facultad de Medicina, Buenos Aires, Argentina.; Three groups of HIV-positive men and a control group of healthy subjects were evaluated simultaneously by delayed-type skin tests with recall antigens detection of CD4 cell counts in peripheral blood and the IgE serum levels. Delayed-type skin test reactivity and CD4 cell counts in peripheral blood decreased while IgE
Diagnosis and treatment of disease caused by nontuberculous mycobacteria. This official statement of the American Thoracic Society was approved by the Board of Directors, March 1997. Medical Section of the American Lung Association.: Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 2):S1-25. Unique Identifier : AIDSLINE MED/97425234; Diagnostic criteria of nontuberculous mycobacterial lung disease in HIV-seropositive and -seronegative hosts. The following criteria apply to symptomatic patients with infiltrate, nodular or cavitary disease, or a high resolution computed tomography scan that shows multifocal bronchiectasis and/or multiple small nodul
AIDS in Africa: face the facts [letter; comment]: Br J Hosp Med. 1997 Apr 16-May 6;57(8):412. Unique Identifier : AIDSLINE MED/97420168; Squire SB
[How to manage HIV seropositive or AIDS patients in rural Burkina Faso?]: Sante. 1997 May-Jun;7(3):177-86. Unique Identifier : AIDSLINE MED/97427380; Taverne B; ORSTOM, Burkina Faso.; This article is based on an ethnographical study carried out in 1996. It describes and analyzes the methods of medical and family management of HIV-positive and full-blown AIDS patients in the rural environment of Burkinabe. A number of recommendations are made. Biomedical management of these patients is almost non-ex
[HIV-1 cognitive and motor syndrome]: Sante. 1997 May-Jun;7(3):187-93. Unique Identifier : AIDSLINE MED/97427381; Mussa M; Preux PM; Debrock C; Chazot-Balcon M; Melaku Z; Druet-Cabanac M; Kayembe K; Dumas M; Departement de neurologie, Mont-Amba de l'Universite de Kinshasa,; Republique democratique du Congo.; The central nervous system (CNS) is often affected by HIV-1 infection. Over 40% of AIDS cases present with neurological symptoms and CNS lesion are detected by anatomical and pathological studies in 80 to 90% of AIDS cases. There may be infections and tumors secondary to the immunodeficiency and pathologies may occur
Quantification of the reservoir of HIV-1.: Trends Microbiol. 1997 Jun;5(6):215-6. Unique Identifier : AIDSLINE MED/97355444; Blacklaws BA; Dept of Clinical Veterinary Medicine, University of Cambridge, UK.; bab2@cam.ac.uk
[Allergic diseases and infection with human immunodeficiency virus (HIV)-AIDS in pediatric patients]: Rev Alerg Mex. 1997 Mar-Apr;44(2):55-9. Unique Identifier : AIDSLINE MED/97328990; Linnemann de Martinez DL; Lopez Perez G; Xochihua Diaz L; Servicio de alergia, Instituto Nacional de Pediatria, Mexico.; During an infection with human immunodeficiency virus (HIV) the immune system is deregulated, even before real immunodeficiency, lymphopenia and AIDS occur. The immunologic alterations that have been described are a differentiation of a T-lymphocyte subclass, Th1 to Th0. Immunologic stimulation of these Th0 cells afte
Anti-HIV ribozymes.: Mol Biotechnol. 1997 Jun;7(3):241-51. Unique Identifier : AIDSLINE MED/97362774; Sun LQ; Ely JA; Gerlach W; Symonds G; Johnson & Johnson Research Laboratories, Sydney NSW, Australia.; HIV is an RNA virus that replicates intracellularly through various RNA intermediates. Several of these can be targeted by ribozymes (catalytic RNA molecules), and a number of investigators, including this group, have demonstrated the ability of ribozymes to suppress HIV replication in this way. It is argued that this
HIV and women using empowerment as a prevention tool.: N HC Perspect Community. 1997 Jan-Feb;18(1):6-9. Unique Identifier : AIDSLINE MED/97291692; Highsmith CS
[Reconstitution of Hu-SCID mice transplanted with human tonsillar lymphocytes immunized with dengue virus-2 in vitro and its immune response]: Chung Hua I Hsueh Tsa Chih. 1996 Aug;76(8):597-9. Unique Identifier : AIDSLINE MED/97421045; Zuo L; Guo H; Zhang C; Department of Microbiology, Guiyang Medical College.; OBJECTIVE: To study the measure for the reconstitution of severe combined immunodeficient disease mice (SCID mice) transplanted with human lymphocytes immunized with specific antigen in vitro. METHODS: Hu-SCID mice were constructed by intraperitoneal (i.p.) transfer of human tonsillar lymphocytes (TLC) first immunized
Expression of adhesion molecules on mononuclear cells from individuals with stable atopic asthma.: Clin Exp Allergy. 1997 Jun;27(6):664-71. Unique Identifier : AIDSLINE MED/97351905; Tomita K; Tanigawa T; Yajima H; Sano H; Fukutani K; Hitsuda Y; Matsumoto Y; Sasaki T; Third Department of Internal Medicine, Faculty of Medicine, Tottori; University, Japan.; Activated mononuclear cells (lymphocytes and monocytes) (MNCs) circulate in peripheral blood and accumulate in the airways of individuals with steady-state asthma. The expression of adhesion molecules on MNCs of 10 patients with steady-state atopic asthma and 10 non-atopic control subjects was measured by flow cytomet
[Infection of the gastrointestinal tract by cytomegalovirus]: Gastroenterol Hepatol. 1997 Jun-Jul;20(6):315-21. Unique Identifier : AIDSLINE MED/97403809; Coll I; Garau J; Departamento de Medicina, Hospital Mutua de Terrassa, Barcelona.
Detection of JC and BK viral genome in specimens of HIV-1 infected subjects.: New Microbiol. 1997 Apr;20(2):115-22. Unique Identifier : AIDSLINE MED/97352139; Degener AM; Pietropaolo V; Di Taranto C; Rizzuti V; Ameglio F; Cordiali Fei P; Caprilli F; Capitanio B; Sinibaldi L; Orsi N; Department of Cellular and Developmental Biology, University La; Sapienza, Rome, Italy.; Human polyomaviruses JC and BK are ubiquitous in healthy human adults, persist as latent viruses and can be reactivated in the immunodeficient host giving different pathologies. Due to the experimental evidence of their potential oncogenicity and neurotropism, as well as to the enhanced viral production induced by co-
Molecular analysis of HTLV-I and HTLV-II isolates from Italian blood donors, intravenous drug users and prisoners.: New Microbiol. 1997 Apr;20(2):93-104. Unique Identifier : AIDSLINE MED/97352137; Ferrante P; Mancuso R; Zuffolato R; Puricelli S; Mannella E; Romano L; Zanetti A; Cattaneo E; Corrao V; Don C. Gnocchi Foundation, IRCCS (Research Hospital), Biology; Laboratory, Milan, Italy.; Using molecular methods three or five major variants of HTLV-I have been identified; moreover two subtypes of HTLV-II defined as HTLV-IIa and HTLV-IIb with six variants within each of these groups have been described. In the present study we analysed proviral DNA obtained from the peripheral blood mononuclear cells PB
Isolation of HTLV-1 from an aggressive form of ATL in a Romanian patient not at risk of infection and with seronegative family members.: New Microbiol. 1997 Jul;20(3):177-85. Unique Identifier : AIDSLINE MED/97403580; Manca N; Ferremi P; De Simone N; Pirali F; Turano A; Institute of Microbiology of Brescia University, Spedali Civili.; We present the clinical, virological and haematochemical data of a 22 year old patient from Romania with Adult T Cell Leukaemia ATL). Viral isolation in peripheral mononuclear blood cells PMBC), detection of DNA sequences of HTLV-1 by Polymerase Chain Reaction (PCR) and of antibod
The use of radioimmune western blotting to evaluate indeterminate western blotting results in blood donor HIV serodiagnosis.: New Microbiol. 1997 Jul;20(3):277-81. Unique Identifier : AIDSLINE MED/97403591; Portincasa P; Conti G; Visalli S; Talarico E; Chezzi C; Istituto di Microbiologia, Facolta di Medicina e Chirurgia, Universita; degli Studi di Parma, Italy.; The serodiagnosis of HIV infection is sometimes puzzling due to questionable indeterminate results obtained by western blotting wb), the confirmatory test used world-wide after a positive or borderline ELISA result. These situations cause anxiety in the person being tested and determine additional laboratory costs.
Medicine behind bars and other lessons from the AIDS epidemic.: Med Health R I. 1997 Aug;80(8):242-3. Unique Identifier : AIDSLINE MED/97428713; Flanigan T; Medicine Department, Miriam Hospital.
In vivo metabolic profile of a phosphorothioate oligodeoxyribonucleotide.: Antisense Nucleic Acid Drug Dev. 1997 Jun;7(3):159-65. Unique Identifier : AIDSLINE MED/97356470; Temsamani J; Roskey A; Chaix C; Agrawal S; Hybridon, Inc. Cambridge, MA 02139, USA.; Antisense phosphorothioate oligodeoxyribonucleotides (PS oligonucleotides) have the ability to inhibit individual gene expression in the potential treatment of cancer and viral diseases. Following administration in vivo, PS oligonucleotides are rapidly cleared from the plasma and distributed to various organs. However
Identification of a phosphodiester hexanucleotide that inhibits HIV-1 infection in vitro on covalent linkage of its 5'-end with a dimethoxytrityl residue.: Antisense Nucleic Acid Drug Dev. 1997 Jun;7(3):167-75. Unique Identifier : AIDSLINE MED/97356471; Furukawa H; Momota K; Agatsuma T; Yamamoto I; Kimura S; Shimada K; Biological Research Laboratories, Sankyo Co. Ltd, Tokyo, Japan.; It has been shown in previous reports that a guanine-rich phosphodiester oligonucleotide bearing a dimethoxytrityl (DmTr) residue on its 5 -terminal. DmTr-TGGGAGGTGGGTCTG (SA-1042), is an inhibitor of HIV-1 infection in vitro. SA-1042 interfered with the attachment of gp120 to the CD4 receptor and the subsequent entry
Itraconazole oral solution versus clotrimazole troches for the treatment of oropharyngeal candidiasis in immunocompromised patients.: Clin Ther. 1997 May-Jun;19(3):471-80. Unique Identifier : AIDSLINE MED/97363919; Murray PA; Koletar SL; Mallegol I; Wu J; Moskovitz BL; Ohio State University Medical Center, Columbus, USA.; This multicenter, open-label, third-party-masked trial compared the efficacy and safety of itraconazole oral solution (200 mg once daily) and clotrimazole troches (10 mg five times daily) in a population of immunocompromised subjects composed primarily of patients with human immunodeficiency virus (HIV)/acquired immun
Quantitative competitive RNA PCR for quantitation of virion-associated HIV-1 RNA.: Methods. 1997 Aug;12(4):294-9. Unique Identifier : AIDSLINE MED/97401511; Brichacek B; Stevenson M; Program in Molecular Medicine, University of Massachusetts Medical; Center, Worcester 01655, USA.; Quantitative competitive PCR is a highly sensitive technique that allows accurate quantitation of small amounts of RNA. We have modified the original method to include the use of an internal standard at all stages of sample analysis. In this way, the method can accommodate for variations in the recovery of viral parti
Resting cell neutralization assay for HIV-1 primary isolates.: Methods. 1997 Aug;12(4):300-5. Unique Identifier : AIDSLINE MED/97401512; Hioe C; Burda S; Chigurupati P; Xu S; Zolla-Pazner S; New York University Medical Center, New York 10016, USA.; A technique is described for detecting the activity of neutralizing polyclonal or monoclonal antibodies against HIV-1 primary isolates. Most commonly, neutralizing antibody activity for HIV-1 is assessed by quantifying the ability of antibodies to inhibit virus infection in mitogen-activated peripheral blood mononucle
In vitro assays for activities of retroviral integrase.: Methods. 1997 Aug;12(4):306-17. Unique Identifier : AIDSLINE MED/97401513; Chow SA; Department of Molecular and Medical Pharmacology, UCLA School of; Medicine 90095, USA.; Integration of retroviral DNA, an essential step during the retroviral life cycle, is mediated by the viral protein integrase. Simple in vitro assays for measuring integrase activities are described, including catalysis (3 -end processing, 3 -end joining, disintegration), juxtaposition of viral DNA ends, DNA binding,
Genetic selection in Escherichia coli for active human immunodeficiency virus reverse transcriptase mutants.: Methods. 1997 Aug;12(4):318-24. Unique Identifier : AIDSLINE MED/97401514; Kim B; Department of Pathology, School of Medicine, University of Washington,; Seattle 98195, USA.; Most catalytically active human immunodeficiency virus (HIV) reverse transcriptase (RT) mutants characterized to date have been isolated from the virus after treatment with HIV RT inhibitors such as nucleoside analogs. However, detailed understanding of structure-function relationships, and of the roles of the several
Production of high-titer human immunodeficiency virus type 1 pseudotyped with vesicular stomatitis virus glycoprotein.: Methods. 1997 Aug;12(4):337-42. Unique Identifier : AIDSLINE MED/97401516; Bartz SR; Vodicka MA; Division of Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, WA 98109-1024, USA. sbartz@fred.hcrc.org; We describe a method for the production of high-titer stocks of human immunodeficiency virus type 1 (HIV-1) pseudotyped with vesicular stomatitis virus envelope glycoprotein (VSV G). VSV G pseudotypes provide several advantages over other retroviral envelope proteins. The VSV G envelope is mechanically stable, enablin
Preparation and maintenance of SCID-hu mice for HIV research.: Methods. 1997 Aug;12(4):343-7. Unique Identifier : AIDSLINE MED/97401517; Bristol GC; Gao LY; Zack JA; Department of Medicine, UCLA School of Medicine, USA.; The SCID-hu mouse bearing a functional human thymic implant can be easily infected with HIV. Infection results in virus replication and relatively rapid depletion of CD4+ human thymocytes, resulting in a pathologic profile similar to that seen in the thymus of HIV-infected humans. The use of the SCID-hu model for HIV
Tracking changes in HIV-1 envelope quasispecies using DNA heteroduplex analysis.: Methods. 1997 Aug;12(4):348-54. Unique Identifier : AIDSLINE MED/97401518; Delwart EL; Gordon CJ; Aaron Diamond AIDS Research Center, New York, New York, USA.; delwart@adarc.org; A DNA heteroduplex tracking assay (HTA) using single-stranded probes is described. This assay provides a rapid means of resolving genetic variants coamplified by PCR and of measuring the level of particular variants in complex populations. To confidently detect minor quasispecies changes, the importance of maximizing
Multiple mechanisms contribute to myenteric plexus ablation induced by benzalkonium chloride in the guinea-pig ileum.: Cell Tissue Res. 1997 Aug;289(2):253-64. Unique Identifier : AIDSLINE MED/97361995; Parr EJ; Sharkey KA; Neuroscience Research Group, Department of Physiology and Biophysics,; The University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta,; Canada T2N 4N1.; Ablation of rat myenteric plexus with benzalkonium chloride has provided a model of intestinal aganglionosis, but the degenerative responses are not well understood. We examined the effects of this detergent on neurons and glia, including expression of c-Myc, c-Jun, JunB, and c-Fos, and on immunocytes in the guinea-pi
Linear epitope mapping of humoral responses induced by vaccination with recombinant HIV-1 envelope protein gp160.: J Ind Microbiol Biotechnol. 1997 Jul;19(1):58-65. Unique Identifier : AIDSLINE MED/97426676; Loomis-Price LD; Levi M; Burnett PR; van Hamont JE; Shafer RA; Wahren B; Birx DL; HIV Laboratory, Henry M Jackson Foundation, Rockville, MD 20850, USA.; To enhance utility of the linear epitope mapping (Pepscan) technique for assay of humoral responses linked to vaccination, two modifications were tested. First, peptides were incubated with serum contained in baths rather than individual wells. Second, a rigorous statistical model was developed to determine which pept
Immunization update insert.: Lippincott Health Promot Lett. 1997 Apr;2(4):5-8. Unique Identifier : AIDSLINE MED/97433768
Comparison of BACTEC 12B vs solid media for the recovery of Mycobacterium avium complex from blood cultures in AIDS patients.: Diagn Microbiol Infect Dis. 1997 May;28(1):45-8. Unique Identifier : AIDSLINE MED/97362455; Morgan MB; Reves RR; Wilson ML; Stone BL; Burman WJ; Department of Medicine, University of Colorado School of Medicine,; Denver, USA.; We compared liquid (BACTEC 12B) and solid culture media for the diagnosis of Mycobacterium avian complex (MAC) bacteremia among 258 AIDS patients with a positive blood culture. Neither culture media alone had adequate sensitivity; BACTEC 12B detected growth earlier. Use of both liquid and solid media may improve the y
Erysipelas-like mercury exanthem.: Contact Dermatitis. 1997 May;36(5):277-8. Unique Identifier : AIDSLINE MED/97341684; Descamps V; Lejoyeux F; Marck Y; Bouscarat F; Crickx B; Belaich S; Service de Dermatologie, Hopital Bichat-Claude Bernard, Paris, France.
[Rhabdomyolysis in antiretroviral therapy with Lamivudin]: Dtsch Med Wochenschr. 1997 Aug 15;122(33):1003-6. Unique Identifier : AIDSLINE MED/97430755; Mendila M; Walter GF; Stoll M; Schmidt RE; Abteilung Klinische Immunologie, Medizinischen Hochschule Hannover.; HISTORY AND CLINICAL FINDINGS: Six weeks after antiretroviral treatment with lamivudin (a nucleoside analogue) had been started 300 mg daily) in a 31-year-old man with AIDS developed pain and weakness in his muscles. On admission he had myalgia on pressure and movement as well as weakness of the entire body musculatur
Leishmania major: a clone with low virulence for BALB/c mice elicits a Th1 type response and protects against infection with a highly virulent clone.: Exp Parasitol. 1997 Sep;87(1):47-57. Unique Identifier : AIDSLINE MED/97434071; Li J; Nolan TJ; Farrell JP; Department of Pathobiology, School of Veterinary Medicine, University; of Pennsylvania, Philadelphia 19104, USA.; BALB/c mice are highly susceptible to infection with Leishmania major and generally develop a severe, nonhealing form of disease following parasite inoculation. As opposed to protective Th1 type immune responses which develop in resistant strains of mice, BALB/c mice develop predominant Th2 type responses characterize
Trypanosoma cruzi: T cell subpopulations in the Peyer's patches of BALB/c infected mice.: Exp Parasitol. 1997 Sep;87(1):58-64. Unique Identifier : AIDSLINE MED/97434072; Antunez MI; Feinstein RE; Cardoni RL; Gronvik KO; Instituto Nacional de Parasitologia Dr. M. Fatala Chaben, Buenos; Aires, Argentina.; The changes in the T cell subsets of the Peyer s patches and the thymus were analyzed in BALB/c mice infected with Trypanosoma cruzi, Tulahuen strain. During the acute stage of the infection both lymphoid organs drastically reduced their cellularity. This was mainly due to the decrease in the immature CD4+CD8+ T cell
Sexually transmitted diseases: global importance.: Int J Gynaecol Obstet. 1997 Jul;58(1):107-19. Unique Identifier : AIDSLINE MED/97397634; Sciarra JJ; Department of Obstetrics and Gynecology, Northwestern University; Medical School, Chicago, USA.; The worldwide incidence of sexually transmitted diseases (STDs) including the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) continues to increase and represents a major public health problem especially in the developing world causing infertility and ectopic pregnancy. Prevention of t
HIV and women in Thailand: severity and services.: Int J Gynaecol Obstet. 1997 Jul;58(1):121-7. Unique Identifier : AIDSLINE MED/97397635; Koetsawang S; Auamkul N; Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj; Hospital, Bangkok, Thailand.; Thailand has extensive data on the emergence of HIV and aggressive prevention programs to prevent the spread of the disease. The increasing HIV infection among women who desire pregnancy increases the number of HIV-infected infants. Standard guidelines for HIV testing include tha
Malignant gastrointestinal lymphomas in patients with AIDS.: Digestion. 1997;58(3):218-24. Unique Identifier : AIDSLINE MED/97387053; Heise W; Arasteh K; Mostertz P; Skorde J; Schmidt W; Obst C; Koeppen M; Weiss R; Grosse G; Niedobitek F; L'Age M; Department of Gastroenterology and Infectious Diseases, Anguste; Viktoria Hospital, Berlin, Germany.; HIV-associated malignant lymphomas are a common complication in late HIV infection, and there is a high percentage of gastrointestinal tract involvement. Non-Hodgkin s lymphoma was found in 108 of 2,750 HIV-positive patients (3.9%) in our institution, whereas gastrointestinal manifestation was diagnosed in 48 of 108 p
Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2.: Diabetologia. 1997 Jun;40(6):641-6. Unique Identifier : AIDSLINE MED/97365815; Rothe H; O'Hara RM Jr; Martin S; Kolb H; Diabetes Research Institute, Heinrich-Heine University Dusseldorf,; Germany.; The macrophage product interleukin (IL)-12 is known to drive Th1 reactions in physiological and pathological immune responses. Here we report that treatment with the homodimeric IL-12p40 subunit, an antagonist of the bioactive IL-12p35/p40 heterodimer, suppresses diabetes development in cyclophosphamide-injected NOD m
Human immunodeficiency virus type 1 in an unusual cystic lymphoepithelial lesion of the lung.: Histopathology. 1997 Jul;31(1):83-6. Unique Identifier : AIDSLINE MED/97397590; Marie B; Labouyrie E; Scheid P; Siat J; Menard O; Cosmidis I; Plenat F; Vignaud JM; Laboratoire d'Anatomie Pathologique, Hopital Haut-Leveque Bordeaux,; France.; AIMS: We present the clinical and histopathological findings of an unusual pulmonary cystic lymphoepithelial lesion in an HIV sero-positive patient. METHODS AND RESULTS: The 32-year-old female patient developed two nodules in the vicinity of the right and left hila. Left upper lobectomy showed a 40-mm wide cystic lesi
Systemic lupus erythematosus-associated lymphoproliferative disorder: report of a case and discussion in light of the literature.: Hum Pathol. 1997 Aug;28(8):980-5. Unique Identifier : AIDSLINE MED/97413421; Blanco R; McLaren B; Davis B; Steele P; Smith R; Department of Pathology and Laboratory Medicine, University of; Cincinnati Medical College, OH 45267-0529, USA.; A case of autoimmune disease-associated lymphadenopathy (ADAL) with histological, immunophenotypic, Epstein-Barr virus (EBV) in situ hybridization, and genotypic analyses is presented. The patient had a well-documented history of systemic lupus erythematosus (SLE) and was found at autopsy to have massive lymphadenopat
Effects of interleukin-10 on water intake, locomotory activity, and rectal temperature in rat treated with endotoxin.: Int J Immunopharmacol. 1997 Jan;19(1):31-8. Unique Identifier : AIDSLINE MED/97370101; Nava F; Calapai G; Facciola G; Cuzzocrea S; Marciano MC; De Sarro A; Caputi AP; Institute of Pharmacology, School of Medicine, University of Messina,; Italy.; Intracerebroventricular (i.c.v.) interleukin-10 (25, 50, and 100 ng/rat) effects on water intake, exploratory behaviour, and rectal temperature were evaluated in rats treated intraperitoneally (i.p.) with lipopolysaccharide (0.32, 0.64, and 0.96 mg/kg). Endotoxin administration induced fever and inhibition of thirst i
Analysis of thymic stromal cell subpopulations grown in vitro on extracellular matrix in defined medium--V. Proliferation regulating activities in supernatants of human thymic epithelial cell cultures.: Int J Immunopharmacol. 1997 Jan;19(1):39-47. Unique Identifier : AIDSLINE MED/97370102; Meilin A; Sharabi Y; Shoham J; Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; In previous reports in this series, we described the growth conditions, morphology and supernatant activities of human thymic epithelial cell cultures. The human thymic epithelial cell supernatant (HTES) contained IL-6, G-CSF activities and exhibited a strong enhancing effect on thymocyte proliferative response to mit
AIDS-related risk behaviors and safer sex practices of women in midlife and older in the United States: 1990 to 1992.: Health Care Women Int. 1997 Jul-Aug;18(4):343-54. Unique Identifier : AIDSLINE MED/97433668; Binson D; Pollack L; Catania JA; Department of Medicine, University of California, San Francisco, USA.; diane_binson@quickmail.ucsf.edu; Women in midlife and older represent over 25% of all women with AIDS and 4% of all reported AIDS cases in the United States . We present prevalence estimates and demographic correlates of AIDS-related risk behavior and safer sex practices among women in midlife and older from the Nation
CMV retinitis and dementia in an Indian with AIDS.: J Assoc Physicians India. 1995 Feb;43(2):136-7. Unique Identifier : AIDSLINE MED/97427780; Lehl SS; Bambery P; Avasthi A; Dogra MR; Deodhar SD; Department of Internal Medicine, Postgraduate Institute of Medical; Education and Research, Chandigarh.
Tubercular splenic abscesses in a patient with AIDS.: J Assoc Physicians India. 1996 Aug;44(8):575-7. Unique Identifier : AIDSLINE MED/97395187; Dubey SG; Shah NM; Dayavathi; Mangat GK; Shetty PG; Joshi VR; Dept. of Medicine, P.D. Hinduja National Hospital, Mumbai.; Opportunistic infections are common in patients with AIDS. There is an increasing incidence of tuberculosis, especially extrapulmonary tuberculosis. Splenic abscesses is one such, though rare, extrapulmonary manifestation. We report such a case discuss the diagnosis and treatment in these cases.
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.: J Biol Chem. 1997 Aug 22;272(34):21597-603. Unique Identifier : AIDSLINE MED/97407957; Zhang DH; Cohn L; Ray P; Bottomly K; Ray A; Department of Internal Medicine, Yale University School of Medicine,; New Haven, Connecticut 06520, USA.; Interleukin-5 (IL-5), which is produced by CD4(+) T helper 2 Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma. Despite increasing evidence that the outcome of many diseases is determined by the ratio of the two subsets of CD4(+) T helper cells, Th1 and Th2, the molecular
Translation of an uncapped mRNA involves scanning.: J Biol Chem. 1997 Aug 22;272(34):21642-6. Unique Identifier : AIDSLINE MED/97407963; Gunnery S; Maivali U; Mathews MB; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724,; USA.; tat, an essential gene of human immunodeficiency virus, when placed under the control of the RNA polymerase III promoter from the adenovirus VA RNA1 gene, is transcribed into an uncapped and nonpolyadenylated mRNA. This VA-Tat RNA is translated to produce functional Tat protein in transfected mammalian cells (Gunnery,
Evaluation of a quantitative double ELISA strategy for confirmation and differentiation of HIV infection.: J Virol Methods. 1997 Jul;66(2):203-9. Unique Identifier : AIDSLINE MED/97399631; Rehle TM; Mattke P; Liomba GN; Kramer S; Gershy-Damet GM; Konan K; Sangare A; Zekeng L; Tsague JM; Kaptue L; Eberle J; Gurtler L; Department of Infectious Diseases and Tropical Medicine, University of; Munchen, Germany.; The current HIV pandemic is complicated by the spread of distinct types and subtypes of HIV. The currently used conventional diagnostic tests have shown limitations in the detection of antibodies against all HIV-1 subtypes, as demonstrated by recent identification of HIV-1 subtype O. To evaluate quantitatively the dia
Molecular characterization of HIV viruses generated after in vivo ligation.: J Virol Methods. 1997 Jul;66(2):237-46. Unique Identifier : AIDSLINE MED/97399635; Guillon C; Oriol G; Gruters RA; UMR103 CNRS/bioMerieux, ENS Lyon, France.; During the course of infection, human immunodeficiency virus type 1 (HIV-1) displays wide genotypic and phenotypic differences. Construction of chimeric viruses is useful to determine the genotypic basis that underlies phenotypic variations, but the procedure is time-consuming. Previously, it has been shown that co-tr
Quantification of HIV-1 viral RNA and proviral DNA by isotopic competitive PCR.: J Virol Methods. 1997 Jul;66(2):269-82. Unique Identifier : AIDSLINE MED/97399638; Gratzl S; Moroni C; Hirsch HH; Institute for Medical Microbiology, University of Basel Petersplatz; 10, Switzerland.; A quantitative isotopic competitive PCR (icPCR) assay was established using 32P-labeled primers targeting the HIV-1 gag gene followed by quantification using a phosphoimager. The detection limit varied from 3 to 10 molecules of DNA and 10 to 100 molecules of RNA per reaction. The icPCR quantification of HIV-1 DNA copi
Reactivity and amplification efficiency of the NASBA HIV-1 RNA amplification system with regard to different HIV-1 subtypes.: J Virol Methods. 1997 Jul;66(2):293-301. Unique Identifier : AIDSLINE MED/97399640; Gobbers E; Fransen K; Oosterlaken T; Janssens W; Heyndrickx L; Ivens T; Vereecken K; Schoones R; van de Wiel P; van der Groen G; Organon Teknika, Turnhout, Belgium.; In view of the genetic diversity of the human immunodeficiency virus Type 1, we assessed the sensitivity and quantification efficiency of the HIV-1 RNA NASBA amplification system with respect to different HIV-1 subtypes and recombinants. Twenty cell culture supernatants representing 17 HIV-1 group M and 3 group O stra
Clinical pathways in home nutrition support.: J Am Diet Assoc. 1997 Sep;97(9):1003-7. Unique Identifier : AIDSLINE MED/97430780; Ireton-Jones C; Orr M; Hennessy K; Nutrition Program Management, Coram Healthcare, Carrollton, Tex., USA.; In home-care settings, physicians with various medical specialties may order home enteral and/or parenteral nutrition support. Clinical pathways may be used to provide a clear, concise, standardized method for ordering and monitoring home nutrition support. The clinical pathways should be appropriate for 80% of the pa
Herpes zoster ophthalmicus and the immunocompromised host: a case report and review.: J Am Optom Assoc. 1997 Aug;68(8):527-38. Unique Identifier : AIDSLINE MED/97424940; McPherson RE; Moore Eye Institute, Brandywine Hospital, Exton, Pennsylvania, USA.; BACKGROUND: Herpes zoster is the secondary form of varicella zoster virus disease, caused by the reactivation of the dormant virus in the sensory ganglia. It manifests as a unilateral cutaneous dermatitis with a prodromal fever and malaise. Herpes zoster ophthalmicus occurs when the ophthalmic division of the trigemin
Knowledge and attitudes of pregnant women regarding AIDS in a semi arid area of Rajasthan.: J Commun Dis. 1997 Jun;29(2):139-44. Unique Identifier : AIDSLINE MED/97427610; Singh MB; Chaudhary RC; Haldiya KR; Desert Medicine Research Centre (ICMR), Jodhpur, Rajasthan.; A total of 792 pregnant women from three hospitals of Jaipur were surveyed to assess and compare their knowledge and attitudes regarding various aspects of AIDS. Observations revealed that level of knowledge was significantly higher in pregnant women from upper income group than low income group (P
Guided Imagery. A psychoneuroimmunological intervention in holistic nursing practice.: J Holist Nurs. 1997 Jun;15(2):112-27. Unique Identifier : AIDSLINE MED/97308577; Giedt JF; Moorhead State University, USA.; Guided imagery is an independent nursing intervention that uses psychoneuroimmunology (PNI) principles to assist an individual in the management of distressing symptoms. The purpose of this article is to discuss the use of guided imagery in holistic nursing practice. The concepts of PNI are described and the basic ste
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.: J Nat Prod. 1997 Jul;60(7):677-83. Unique Identifier : AIDSLINE MED/97393465; Hallock YF; Manfredi KP; Dai JR; Cardellina JH 2nd; Gulakowski RJ; McMahon JB; Schaffer M; Stahl M; Gulden KP; Bringmann G; Francois G; Boyd MR; Laboratory of Drug Discovery Research and Development, National Cancer; Institute, Frederick, Maryland 21702-1201, USA.; New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation
New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica.: J Nat Prod. 1997 Jul;60(7):739-42. Unique Identifier : AIDSLINE MED/97393477; Valsaraj R; Pushpangadan P; Smitt UW; Adsersen A; Christensen SB; Sittie A; Nyman U; Nielsen C; Olsen CE; Division of Ethnopharmacology, Tropical Botanic Garden and Research; Institute, Kerala, India.; A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3 ,4 -(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and a
Immunologic adaptations during pregnancy.: J Obstet Gynecol Neonatal Nurs. 1997 Jul-Aug;26(4):388-94. Unique Identifier : AIDSLINE MED/97396722; Priddy KD; Many complementary changes occur in a pregnant woman s immune system to protect the fetus from attack while maintaining maternal defenses against disease. Enhancements occur in immune elements that fight bacterial infections. Conversely, suppression of T-cell activity causes increased susceptibility to viral infection
Exfoliative cheilitis (EC) in AIDS: association with Candida infection.: J Oral Pathol Med. 1997 Jul;26(6):290-3. Unique Identifier : AIDSLINE MED/97378585; Reichart PA; Weigel D; Schmidt-Westhausen A; Pohle HD; Abteilung fur Oralchirurgie und zahnarztliche Rontgenologie,; Medizinische Fakultat, Humboldt-Universitat zu Berlin, Germany.; Forty-seven of 165 patients with AIDS (28.5%) showed exfoliative cheilitis (EC), predominantly of the lower lip (n = 37). Histologically, hyphae were revealed in 23 of 47 cases (49%). In 14 of 23 specimens the histological and microbiological findings were in accordance. Smears of the vermilion border revealed Candida
Localised oral histoplasmosis lesions associated with HIV infection.: J Oral Pathol Med. 1997 Jul;26(6):294-6. Unique Identifier : AIDSLINE MED/97378586; Warnakulasuriya KA; Harrison JD; Johnson NW; Edwards S; Taylor C; Pozniak AL; RCS Department of Dental Sciences/WHO Collaborating Centre for Oral; Cancer and Precancer, King's College School of Medicine and Dentistry,; London, England.; Opportunistic fungal infections account for a significant amount of morbidity associated with HIV disease. We report here a case of localised oral histoplasmosis without evidence of disseminated disease in a patient who lacked stigmata of HIV disease at the time of initial presentation. The diagnosis is based on histo
Intravenous immunoglobulin in symptomatic and asymptomatic children with perinatal HIV infection.: J Natl Med Assoc. 1997 Aug;89(8):543-7. Unique Identifier : AIDSLINE MED/97409897; Olopoenia L; Young M; White D; Barnes S; Rahbar F; Fomufod A; Department of Pediatrics, DC General Hospital, Washington, DC 20012,; USA.; One hundred thirty-five children born to human immunodeficiency virus (HIV)-infected mothers were selected randomly to receive immunoglobulin (Gamimune-N, Miles Pharmaceutical Co) 200 mg/kg monthly for 1 year. All patients were seropositive by ELISA and Western blot at birth. At the time of the study, 15 symptomatic P
Expression status of Tax protein in human T-cell leukemia virus type 1-transformed MT4 cells: recall of MT4 cells distributed by the NIH AIDS Research and Reference Reagent Program.: J Virol. 1997 Sep;71(9):6277-8. Unique Identifier : AIDSLINE MED/97404631; Jeang KT; Derse D; Matocha M; Sharma O; Molecular Virology Section, NIAID, NIH, Bethesda, Maryland 20892-0460,; USA. kjeang@atlas.niaid.nih.gov
Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His).: J Virol. 1997 Sep;71(9):6315-22. Unique Identifier : AIDSLINE MED/97404636; Li Y; Zhang Z; Wakefield JK; Kang SM; Morrow CD; Department of Microbiology, University of Alabama at Birmingham 35294,; USA.; Sequence analysis of integrated proviruses of human immunodeficiency virus type 1 (HIV-1) which utilize tRNA(His) to initiate reverse transcription [virus derived from pHXB2(His-AC-TGT)] revealed five additional nucleotide substitutions in the U5 and primer binding site (PBS) regions ATGAC for CCTGT at nucleotides 152
Evolution of the human immunodeficiency virus type 1 subtype-specific V3 domain is confined to a sequence space with a fixed distance to the subtype consensus.: J Virol. 1997 Sep;71(9):6332-8. Unique Identifier : AIDSLINE MED/97404638; Lukashov VV; Goudsmit J; Department of Human Retrovirology, Academic Medical Center, University; of Amsterdam, The Netherlands.; Human immunodeficiency virus type 1 (HIV-1) strains can be separated into genetic subtypes based on phylogenetic analysis of the envelope gene. Once it had been shown that population-wide intrasubtype genetic variation of HIV-1 strains increases in the course of the AIDS epidemic, it remained uncertain whether HIV-1 s
Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.: J Virol. 1997 Sep;71(9):6339-47. Unique Identifier : AIDSLINE MED/97404639; Mahalingam S; Ayyavoo V; Patel M; Kieber-Emmons T; Weiner DB; Department of Pathology, School of Medicine, University of; Pennsylvania Medical Center, Philadelphia 19104, USA.; The vpr gene product of human immunodeficiency virus type 1 HIV-1) is a virion-associated protein that is essential for efficient viral replication in monocytes/macrophages. Vpr is primarily localized in the nucleus when expressed in the absence of other viral proteins. Vpr is packaged efficiently into viral particles
pol gene diversity of five human immunodeficiency virus type 1 subtypes: evidence for naturally occurring mutations that contribute to drug resistance, limited recombination patterns, and common ancestry for subtypes B and D.: J Virol. 1997 Sep;71(9):6348-58. Unique Identifier : AIDSLINE MED/97404640; Cornelissen M; van den Burg R; Zorgdrager F; Lukashov V; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre, Amsterdam,; The Netherlands. M.I.Cornelissen@amc.uva.nl; Naturally occurring mutations in the polymerase gene of human immunodeficiency virus type 1 (HIV-1) have important implications for therapy and the outcome of clinical studies. Using 42 virus isolates obtained from the UNAIDS sample collection, we analyzed the protease (99 amino ac
Placental trophoblasts resist infection by multiple human immunodeficiency virus (HIV) type 1 variants even with cytomegalovirus coinfection but support HIV replication after provirus transfection.: J Virol. 1997 Sep;71(9):6359-72. Unique Identifier : AIDSLINE MED/97404641; Kilani RT; Chang LJ; Garcia-Lloret MI; Hemmings D; Winkler-Lowen B; Guilbert LJ; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada.; Whether cell-free human immunodeficiency virus type 1 (HIV-1) can productively infect placental trophoblasts (which in turn could transmit the virus into the fetal circulation) is controversial but essential to know for the evaluation of alternative routes such as cell-mediated infection or trophoblast damage). We hav
Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.: J Virol. 1997 Sep;71(9):6486-94. Unique Identifier : AIDSLINE MED/97404655; Mhashilkar AM; Biswas DK; LaVecchio J; Pardee AB; Marasco WA; Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston,; Massachusetts 02115, USA.; Human immunodeficiency virus type 1 (HIV-1) Tat, an early regulatory protein that is critical for viral gene expression and replication, transactivates the HIV-1 long terminal repeat (LTR) via its binding to the transactivation response element (TAR) and, along with other cellular factors, increases viral transcriptio
Equine infectious anemia virus utilizes a YXXL motif within the late assembly domain of the Gag p9 protein.: J Virol. 1997 Sep;71(9):6541-6. Unique Identifier : AIDSLINE MED/97404662; Puffer BA; Parent LJ; Wills JW; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; We have previously demonstrated that the Gag p9 protein of equine infectious anemia virus (EIAV) is functionally homologous with Rous sarcoma virus (RSV) p2b and human immunodeficiency virus type 1 (HIV-1) p6 in providing a critical late assembly function in RSV Gag-mediated budding from transfected COS-1 cells (L. J.
The amino-terminal fusion domain peptide of human immunodeficiency virus type 1 gp41 inserts into the sodium dodecyl sulfate micelle primarily as a helix with a conserved glycine at the micelle-water interface.: J Virol. 1997 Sep;71(9):6593-602. Unique Identifier : AIDSLINE MED/97404669; Chang DK; Cheng SF; Chien WJ; Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of; China. dkc@chem.sinica.edu.tw; A peptide based on the N-terminal fusion domain of gp41 of human immunodeficiency virus type 1 (HIV-1) and its tryptophan analog were synthesized to examine the secondary structure in the micellar environment. Nuclear magnetic resonance (NMR), circular dichroism and electron paramagnetic resonance experiments indicate
Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites.: J Virol. 1997 Sep;71(9):6662-70. Unique Identifier : AIDSLINE MED/97404676; Zhang YM; Imamichi H; Imamichi T; Lane HC; Falloon J; Vasudevachari MB; Salzman NP; SAIC Frederick, Frederick Cancer Research & Development Center,; National Cancer Institute, Maryland, USA.; Two different responses to the therapy were observed in a group of patients receiving the protease inhibitor indinavir. In one, suppression of virus replication occurred and has persisted for 90 weeks (bDNA,
Human immunodeficiency virus type 1 infection of mature CD3hiCD8+ thymocytes.: J Virol. 1997 Sep;71(9):6671-6. Unique Identifier : AIDSLINE MED/97404677; Lee S; Goldstein H; Baseler M; Adelsberger J; Golding H; Laboratory of Retrovirus Research, Food and Drug Administration,; Bethesda, Maryland 20892, USA.; Although CD4+ cells are the primary targets of human immunodeficiency virus type 1 (HIV-1) infection, earlier reports have suggested that intrathymic infection of CD8+ cells may occur. However, it was unclear whether HIV-1-infected CD8+ thymocytes were truly mature single-positive (SP) cells. In the present study, SCI
Characterization of the genome of feline foamy virus and its proteins shows distinct features different from those of primate spumaviruses.: J Virol. 1997 Sep;71(9):6727-41. Unique Identifier : AIDSLINE MED/97404685; Winkler I; Bodem J; Haas L; Zemba M; Delius H; Flower R; Flugel RM; Lochelt M; Abteilung Retrovirale Genexpression, Forschungsschwerpunkt Angewandte; Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.; The genome of the feline foamy virus (FeFV) isolate FUV was characterized by molecular cloning and nucleotide sequence analysis of subgenomic proviral DNA. The overall genetic organization of FeFV and protein sequence comparisons of different FeFV genes with their counterparts from other known foamy viruses confirm th
Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.: J Virol. 1997 Sep;71(9):6742-8. Unique Identifier : AIDSLINE MED/97404686; Hua J; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710, USA.; Although the Nef proteins encoded by human immunodeficiency virus type 1 (HIV-1) and simian immuno-deficiency virus (SIV) are known to induce the efficient internalization and degradation of cell surface CD4, it remains unclear whether this process involves a direct interaction between Nef and CD4. Here, we report tha
Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements.: J Virol. 1997 Sep;71(9):6834-41. Unique Identifier : AIDSLINE MED/97404696; Camaur D; Gallay P; Swingler S; Trono D; Infectious Disease Laboratory, Salk Institute for Biological Studies,; La Jolla, California 92037, USA.; During virus assembly, a subset of human immunodeficiency virus HIV) matrix (MA) molecules is phosphorylated on C-terminal tyrosine. This modification facilitates infection of nondividing cells by allowing for the recruitment of the karyophilic MA into the viral core and preintegration complex. MA tyrosine phosphoryla
Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off: J Virol. 1997 Sep;71(9):6869-74. Unique Identifier : AIDSLINE MED/97404700; Mo H; Stamatatos L; Ip JE; Barbas CF; Parren PW; Burton DR; Moore JP; Ho DD; Aaron Diamond AIDS Research Center, Rockefeller University, New York,; New York 10016, USA.; IgG1b12, a human monoclonal antibody (MAb) to an epitope overlapping the CD4-binding site on gp120, has broad and potent neutralizing activity against most primary human immunodeficiency virus type 1 (HIV-1) isolates. To assess whether and how escape mutants resistant to IgG1b12 can be generated, we cultured primary H
Priming with live respiratory syncytial virus (RSV) prevents the enhanced pulmonary inflammatory response seen after RSV challenge in BALB/c mice immunized with formalin-inactivated RSV.: J Virol. 1997 Sep;71(9):6935-9. Unique Identifier : AIDSLINE MED/97404709; Waris ME; Tsou C; Erdman DD; Day DB; Anderson LJ; Division of Viral and Rickettsial Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia, USA.; To investigate enhanced disease associated with a formalin-inactivated (FI) respiratory syncytial virus (RSV) vaccine, we studied the pulmonary inflammatory response to RSV in BALB/c mice immunized with live RSV, FI-RSV, or combinations of the two. After RSV challenge, the number of granular cells, the ratio of CD4+/C
Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.: J Virol. 1997 Sep;71(9):6973-81. Unique Identifier : AIDSLINE MED/97404714; Berthoux L; Pechoux C; Ottmann M; Morel G; Darlix JL; LaboRetro, Unite de Virologie Humaine INSERM U412, Ecole Normale; Superieure de Lyon, France.; Nucleocapsid protein NCp7 of human immunodeficiency virus type 1 HIV-1) is a small basic nucleic acid binding protein containing two zinc fingers of the form (CX2CX4HX4C) and is present at about 2,000 copies inside the viral core. NCp7 molecules are tightly associated with the genomic RNA dimer to form the nucleocapsi
Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax.: J Virol. 1997 Sep;71(9):6982-9. Unique Identifier : AIDSLINE MED/97404715; Cowan EP; Alexander RK; Daniel S; Kashanchi F; Brady JN; Division of Transfusion Transmitted Diseases, Food and Drug; Administration, Rockville, Maryland, USA. epc@helix.nih.gov; To examine the role of human T-lymphotropic virus type 1 (HTLV-1) Tax1 in the development of neurological disease, we studied the effects of extracellular Tax1 on gene expression in NT2-N cells, postmitotic cells that share morphologic, phenotypic, and functional features with mature human primary neurons. Treatment w
Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase.: J Virol. 1997 Sep;71(9):7005-11. Unique Identifier : AIDSLINE MED/97404718; Hazuda DJ; Felock PJ; Hastings JC; Pramanik B; Wolfe AL; Department of Antiviral Research, Merck Research Laboratories, West; Point, Pennsylvania 19486, USA.; Previous in vitro analyses have shown that the human immunodeficiency virus type 1 (HIV-1) integrase uses either manganese or magnesium to assemble as a stable complex on the donor substrate and to catalyze strand transfer. We now demonstrate that subsequent to assembly, catalysis of both 3 end processing and strand
The critical N-linked glycan of murine leukemia virus envelope protein promotes both folding of the C-terminal domains of the precursor polyprotein and stability of the postcleavage envelope complex.: J Virol. 1997 Sep;71(9):7012-9. Unique Identifier : AIDSLINE MED/97404719; Li Z; Pinter A; Kayman SC; Department of Microbiology, New York University School of Medicine,; New York, USA.; The infectivity of Friend ecotropic murine leukemia virus was previously shown to be highly sensitive to modification in its envelope protein (Env) at only one of the eight signals for N-linked glycan attachment, the fourth from the N terminus (gs4). In the present study, a set of six single-amino-acid substitutions i
Cell and viral regulatory elements enhance the expression and function of a human immunodeficiency virus inhibitory gene.: J Virol. 1997 Sep;71(9):7020-9. Unique Identifier : AIDSLINE MED/97404720; Ranga U; Woffendin C; Yang ZY; Xu L; Verma S; Littman DR; Nabel GJ; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0650, USA.; Regulated expression of recombinant genes in CD4+ cells is an important objective for gene therapy of AIDS, as these cells represent the principal target for viral replication of human immunodeficiency virus (HIV). We report here that specific combinations of CD4 cell-specific and viral regulatory elements can enhance
Infectious particles derived from Semliki Forest virus vectors encoding murine leukemia virus envelopes.: J Virol. 1997 Sep;71(9):7061-7. Unique Identifier : AIDSLINE MED/97404724; Lebedeva I; Fujita K; Nihrane A; Silver J; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Semliki Forest virus vectors encoding murine leukemia virus (MLV) envelope protein with a truncated cytoplasmic tail generate submicrometer, cell-associated, membranous particles that transmit replication-competent vector RNA specifically to cells bearing the MLV receptor. Such minimal viruses could have application
Varicella-zoster virus open reading frame 4 encodes an immediate-early protein with posttranscriptional regulatory properties.: J Virol. 1997 Sep;71(9):7073-9. Unique Identifier : AIDSLINE MED/97404726; Defechereux P; Debrus S; Baudoux L; Rentier B; Piette J; Laboratory of Fundamental Virology and Immunology, University of; Liege, Belgium.; Varicella-zoster virus (VZV) encodes four putative immediate-early proteins based on sequence homology with herpes simplex virus type 1: the products of ORF4, -61, -62, and -63. Until now, only two VZV proteins have been described as being truly expressed with immediate-early kinetics (IE62 and IE63). The ORF4-encoded
The relationship between tumor necrosis factor and human immunodeficiency virus gene expression in lymphoid tissue.: J Virol. 1997 Sep;71(9):7080-2. Unique Identifier : AIDSLINE MED/97404727; Li Q; Gebhard K; Schacker T; Henry K; Haase AT; Department of Microbiology, University of Minnesota, Minneapolis, USA.; In tissue culture models of chronic human immunodeficiency virus type 1 (HIV-1) infection, cytokines such as tumor necrosis factor alpha (TNF-alpha) activate viral gene expression. We sought evidence that TNF-alpha might similarly regulate viral gene expression in vivo in the major lymphoid tissue (LT) reservoir. We u
The rapid spread of recombinants during a natural in vitro infection with two human immunodeficiency virus type 1 strains.: J Virol. 1997 Sep;71(9):7088-91. Unique Identifier : AIDSLINE MED/97404729; Kuwata T; Miyazaki Y; Igarashi T; Takehisa J; Hayami M; Institute for Virus Research, Kyoto University, Japan.; We quantified a population of recombinants in a natural in vitro infection, using wild-type viruses without any pressure. It was found that recombinants emerged early after infection and constituted more than 20% of the whole proviral population 15 days after infection. Furthermore, recombinants were isolated as infec
A single amino acid substitution in the transmembrane envelope glycoprotein of feline immunodeficiency virus alters cellular tropism.: J Virol. 1997 Sep;71(9):7132-5. Unique Identifier : AIDSLINE MED/97404738; Vahlenkamp TW; Verschoor EJ; Schuurman NN; van Vliet AL; Horzinek MC; Egberink HF; de Ronde A; Department of Infectious Diseases and Immunology, Faculty of; Veterinary Medicine, Utrecht University, The Netherlands.; vahlen@rz.uni-leipzig.de; The cellular tropism of the feline immunodeficiency virus (FIV) is affected by changes in variable region 3 (V3) of the surface SU) envelope glycoprotein (Verschoor, E. J., et al., J. Virol. 69:4752-4757, 1995). By using high-dose DNA transfection, an FIV molecular clone with a non-CRFK-tropic V3 acquired the ability
Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins.: J Virol. 1997 Sep;71(9):7140-4. Unique Identifier : AIDSLINE MED/97404740; Greenberg ME; Ostapenko DA; Mathews MB; Cold Spring Harbor Laboratory, New York 11724, USA.; The Tat protein is a potent activator of human immunodeficiency virus type 1 transcription. Tat has been shown to act by increasing both transcription initiation and elongation, but a detailed understanding of its interaction with the transcriptional machinery is lacking. With the aim of isolating cellular proteins th
Treatment of metastatic renal cell carcinoma with nephrectomy, interleukin-2 and cytokine-primed or CD8(+) selected tumor infiltrating lymphocytes from primary tumor.: J Urol. 1997 Sep;158(3 Pt 1):740-5. Unique Identifier : AIDSLINE MED/97402693; Figlin RA; Pierce WC; Kaboo R; Tso CL; Moldawer N; Gitlitz B; deKernion J; Belldegrun A; Department of Medicine, UCLA School of Medicine, Johnson Comprehensive; Cancer Center, Los Angeles, California 90095-7059, USA.; PURPOSE: Metastatic renal cell carcinoma is a disease with a mean survival of 6 to 10 months. Interleukin-2 ( IL-2 ), the only approved therapy for metastatic renal cell carcinoma, is associated with a 14% response rate and durable remissions in some patients with high p
[Sugar diabetes in AIDS patients treated with antiretroviral nucleoside analogs]: Journ Annu Diabetol Hotel Dieu. 1997;:43-8. Unique Identifier : AIDSLINE MED/97407164; Mauvais-Jarvis F; Larger E; Assan R; Research Division, Joslin Diabetes Center, Boston, USA.
Effectiveness of needle-exchange programmes for prevention of HIV infection.: Lancet. 1997 Jun 21;349(9068):1797-800. Unique Identifier : AIDSLINE MED/97414521; Hurley SF; Jolley DJ; Kaldor JM; Department of Public Health and Community Medicine, University of; Melbourne, Australia. shurley@csl.com.au; BACKGROUND: Needle-exchange programmes (NEPs) are potentially a key strategy for containing the spread of HIV infection among injecting drug users, but their implementation has been limited by uncertainty about their effectiveness. We used an ecological study design to compare changes over time in HIV seroprevalence i
FDA warns of potential protease-inhibitor link to hyperglycaemia [news]: Lancet. 1997 Jun 21;349(9068):1819. Unique Identifier : AIDSLINE MED/97414533; Ault A
Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile?: Lancet. 1997 Jun 21;349(9068):1831-3. Unique Identifier : AIDSLINE MED/97414535; Rook GA; Zumla A; Department of Bacteriology, University College London Medical School,; UK.; The symptoms of Gulf War syndrome are compatible with the hypothesis that the immune system of affected individuals is biased towards a Th2-cytokine pattern. Factors that could lead to a Th2 shift among Gulf War veterans include exposure to multiple Th2-inducing vaccinations under stressful circumstances and the way i
British HIV Association guidelines for antiretroviral treatment of HIV seropositive individuals [letter; comment]: Lancet. 1997 Jun 21;349(9068):1837. Unique Identifier : AIDSLINE MED/97414538; Carey PB; Lloyd J; Timmins D
British HIV Association guidelines for antiretroviral treatment of HIV seropositive individuals [letter; comment]: Lancet. 1997 Jun 21;349(9068):1837; discussion 1838-9. Unique Identifier : AIDSLINE MED/97414537; Payne N
British HIV Association guidelines for antiretroviral treatment of HIV seropositive individuals [letter; comment]: Lancet. 1997 Jun 21;349(9068):1837-8. Unique Identifier : AIDSLINE MED/97414539; Brettle RP; Burns SB; Povey S; Leen CL; Welsby PD
British HIV Association guidelines for antiretroviral treatment of HIV Seropositive individuals [letter; comment]: Lancet. 1997 Jun 21;349(9068):1838. Unique Identifier : AIDSLINE MED/97414540; Harindra V
Viral kinetics in HIV-1 perinatal infection [letter]: Lancet. 1997 Aug 16;350(9076):493. Unique Identifier : AIDSLINE MED/97420086; Krivine A; Le Bourdelles S; Firtion G; Lebon P
Tackling bacterial vaginosis and HIV in developing countries [comment]: Lancet. 1997 Aug 23;350(9077):530-1. Unique Identifier : AIDSLINE MED/97430662; Mayaud P; Department of infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.
HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis [see comments]: Lancet. 1997 Aug 23;350(9077):546-50. Unique Identifier : AIDSLINE MED/97430669; Sewankambo N; Gray RH; Wawer MJ; Paxton L; McNaim D; Wabwire-Mangen F; Serwadda D; Li C; Kiwanuka N; Hillier SL; Rabe L; Gaydos CA; Quinn TC; Konde-Lule J; Makerere University, Kampala, Uganda.; BACKGROUND: In-vitro research has suggested that bacterial vaginosis may increase the survival of HIV-1 in the genital tract. Therefore, we investigated the association of HIV-1 infection with vaginal flora abnormalities, including bacterial vaginosis and depletion of lactobacilli, after adjustment for sexual activity
Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy [letter; comment]: Lancet. 1997 Aug 23;350(9077):588; discussion 590. Unique Identifier : AIDSLINE MED/97430685; Mitchell SM; Youle MS; Membrey WL; Jones CD
Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy [letter; comment]: Lancet. 1997 Aug 23;350(9077):589; discussion 590. Unique Identifier : AIDSLINE MED/97430688; Carr A; Cooper DA
Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy [letter; comment]: Lancet. 1997 Aug 23;350(9077):589; discussion 590. Unique Identifier : AIDSLINE MED/97430687; Stricker RB; Goldberg B
Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy [letter; comment]: Lancet. 1997 Aug 23;350(9077):589-90. Unique Identifier : AIDSLINE MED/97430689; Stein DS
AIDS: safety, regulation and the law in procedures using blood and blood products.: Med Sci Law. 1997 Jul;37(3):215-27. Unique Identifier : AIDSLINE MED/97409903; Craven BM; Stewart GT; Khan M; Business School, University of Northumbria, Newcastle upon Tyne.; The purpose of this paper is to examine issues of regulation of the market for, and use of, blood and blood products. The situation has changed since the discovery of the Human Immune Deficiency Virus (HIV), the presumed cause of AIDS, because it was recognized that some haemophiliacs were infected with HIV from trans
Diagnostic tests for HIV.: Med Lett Drugs Ther. 1997 Aug 29;39(1008):81-3. Unique Identifier : AIDSLINE MED/97432384
HIV-1-infected myelomonocytic cells are resistant to Fas-mediated apoptosis: effect of tumor necrosis factor-alpha on their Fas expression and apoptosis.: Med Microbiol Immunol (Berl). 1997 Jun;186(1):11-7. Unique Identifier : AIDSLINE MED/97399661; Okamoto M; Makino M; Kitajima I; Maruyama I; Baba M; Division of Human Retroviruses, Faculty of Medicine, Kagoshima; University, Japan.; To get insight into the involvement of tumor necrosis factor-alpha (TNF-alpha) and Fas (CD95) ligand in apoptosis programmed cell death) of monocyte/macrophages in HIV-1-infected individuals, various T cell and myelomonocytic cell lines, including the HIV-1-infected clones OM-10.1 and U1 cells, were cultured in the pr
T cell receptor specificities of Toxoplasma gondii-reactive mouse CD4+ T lymphocytes and Th1 clones.: Med Microbiol Immunol (Berl). 1997 Jun;186(1):25-30. Unique Identifier : AIDSLINE MED/97399663; Reichmann G; Dlugonska H; Fischer HG; Institute for Medical Microbiology and Virology,; Heinrich-Heine-University, Dusseldorf, Germany.; The Toxoplasma gondii-directed CD4+ T cell response in chronically infected mice was studied with respect to both T cell receptor diversity and antigen specificities. T cell receptor chains V beta 4, 6, 8, 10, and 14 were predominantly found on toxoplasma-reactive CD4+ splenocytes. This repertoire was also detected am
[Viral load--significance for individualized therapy]: Med Klin. 1997 Jun 15;92(6):344-6. Unique Identifier : AIDSLINE MED/97375989; Jager H; KIS - Kuratorium fur Immunschwache, Munchen.; The treatment of HIV infection/AIDS has changed dramatically because of a new pathophysiological understanding of this disease. The most important laboratory parameter for the management of antiretroviral therapy is the direct measurement of virus load in plasma. In Germany 11 dif
[Disseminated cryptococcosis with extensive cutaneous involvement in AIDS]: Med Klin. 1997 Jun 15;92(6):354-7. Unique Identifier : AIDSLINE MED/97375991; Arasteh K; Heil HD; Reupke H; Kuhnl-Petzoldt C; Grosse G; Futh U; Staib F; II. Innere Klinik Auguste-Viktoria-Krankenhaus, Berlin.; BACKGROUND: Diagnosis of an ulceratively decaying indolent papule in the skin of an AIDS patient. CASE REPORT: In a 36-year-old HIV-positive man with a CD4 lymphocyte count of 60/microliters, a diagnosis of disseminated cryptococcosis was established based on a biopsy of an ulceratively decaying indolent papule in the
A trial of three regimens to prevent tuberculosis in Ugandan adults infected with the human immunodeficiency virus. Uganda-Case Western Reserve University Research Collaboration [see comments]: N Engl J Med. 1997 Sep 18;337(1