Synthesis, antiviral and antiproliferative activity of a new class of 5-(alkyl or arylthio)-6-vinyl uracils. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Synthesis, antiviral and antiproliferative activity of a new class of 5-(alkyl or arylthio)-6-vinyl uracils.

Anticancer Drug Des. 1996 Dec;11(8):597-609. Unique Identifier : AIDSLINE MED/97175088
Baraldi PG; Cacciari B; Romagnoli R; Spalluto G; Garuti L; Roberti M; Pani A; Perra G; Scintu F; Pinna N; Musiu C; La Colla P

Abstract: Uracil derivatives bearing substituted or unsubstituted vinyl groups at position C6 and alkyl- or arylthio groups at position C5 were synthesized and tested in vitro for antiviral and antiproliferative activity. None of the compounds were active against HIV-1. However, some of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations. The maximum potency of antiproliferative activity correlates with the presence of unsubstituted vinyl groups and alkyl- or arylthio substituents.
Keywords: *Anti-HIV Agents/PHARMACOLOGY *Antineoplastic Agents/CHEMICAL SYNTHESIS *Thionucleotides/CHEMICAL SYNTHESIS *Uracil/ANALOGS & DERIVATIVES *Vinyl Compounds/CHEMICAL SYNTHESISKWDanti-hivagents/pharmacologyKWDantineoplasticagents/chemicalsynthesisKWDthionucleotides/chemicalsynthesisKWDuracil/analogs&derivativesKWDvinylcompounds/chemicalsynthesis
970530
M9751988

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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