1997

Living with HIV : new treatments, new hopes. [videorecording]: [United States] : Information Television Network, c1996 1 videocassette (20 min.) : sd., col. ; 1/2 in (Cutting edge medical report) Unique Identifier : AIDSLINE MED/9615298; Volberding P; (Producer) This program examines the future of treatment for the AIDS/HIV virus, exploring advances in drug therapy, the latest breakthroughs in research, and a discussion of the HIV-2 virus. Featured in the program are highly respected medical professionals in the area of AIDS research: Dr. Michael Saag and Dr. Geor
Update HIV infection : diagnosis and treatment of oral manifestations. [sound recording]: [Chicago, Ill.] : Chicago Dental Society, [1994] 2 sound cassettes : analog Unique Identifier : AIDSLINE MED/9443471; Silverman S
AIDS-Bilanz : Bericht der Bayerischen Staatsregierung uber die bisher durchgefuhrten Massnahmen zur AIDS-Bekampfung 1987-1992).: Munchen : Bayerisches Staatsministerium fur Arbeit und Sozialordnung, Familie, Frauen und Gesundheit, [1994] 136 p Unique Identifier : AIDSLINE MED/9616431
AIDS : safety, sexuality, and risk.: London ; Bristol, PA : Taylor & Francis, 1995 vii, 232 p. : ill Social aspects of AIDS) Unique Identifier : AIDSLINE MED/9613333; Aggleton P; Davies P; Hart G
ATL to AIDS.: Tokyo : Nankodo, 1994 viii, 150 p. : ill (Molecular medicine series) Unique Identifier : AIDSLINE MED/9501074; Hatanaka M
Witnessing disease : autopathographies of AIDS and syphilis in 16th and 20th century Germany.: [Ithaca, N.Y.? : s.n.], c1992 vii, 188 p Unique Identifier : AIDSLINE MED/9614289; Hahn RL
Anti-AIDS drug development : challenges, strategies, and prospects.: [Chur, Switzerland?] ; United States : Harwood Academic Publishers, c1995 x, 298 p. : ill Unique Identifier : AIDSLINE MED/9700251; Mohan P; Baba M
AIDS and the body politic : biomedicine and sexual difference.: London ; New York : Routledge, 1996 xii, 169 p. : ill (Writing corporealities) Unique Identifier : AIDSLINE MED/9615979; Waldby C
AIDS trauma and support group therapy : mutual aid, empowerment, connection.: New York : Free Press, c1996 ix, 214 p Unique Identifier : AIDSLINE MED/9618061; Gabriel MA
Book of abstracts : the Fifth European Conference on Clinical Aspects and Treatment of HIV Infection, Copenhagen, Denmark, September 26-29, 1995.: [Hellerup, Denmark : International Conference Services, 1995?] 142 p. : ill Unique Identifier : AIDSLINE MED/9700239
Counselling in HIV infection and AIDS. 2nd ed.: Oxford ; Cambridge, Mass. : Blackwell Science, 1996 viii, 325 p. : ill Unique Identifier : AIDSLINE MED/9616178; Green J; McCreaner A
Crossing borders : migration, ethnicity, and AIDS.: London ; Bristol, PA : Taylor & Francis, 1996 xiv, 257 p. : ill Social aspects of AIDS) Unique Identifier : AIDSLINE MED/9700441; Haour-Knipe M; Rector R
Health workers and AIDS : research, intervention, and current issues in burnout and response.: [Chur, Switzerland?] ; United States : Harwood Academic Publishers, c1995 xv, 419 p. : ill Unique Identifier : AIDSLINE MED/9700250; Bennett L; Miller D; Ross MW
HIV a uklad odpornosciowy. Wyd. 2. zmienione.: Krakow : Nakl. Uniwersytetu Jagiellonskiego, 1994 73 p. : ill Skrypty uczelniane / Uniwersytet Jagiellonski, ISSN 0239-6017 ; nr. 703) Unique Identifier : AIDSLINE MED/9507194; Plytycz B; 703
HIV/AIDS community information services : experiences in serving both at-risk and HIV-infected populations.: New York : Haworth Press, c1996 144 p (Haworth medical information sources) Unique Identifier : AIDSLINE MED/9612327; Huber JT
HIV, AIDS, and childbearing : public policy, private lives.: New York : Oxford University Press, 1996 xx, 492 p. : ill Unique Identifier : AIDSLINE MED/9613474; Faden RR; Kass NE
Nihon no eizu.: Tokyo : Akashi Shoten, 1994 162 p. : ill Unique Identifier : AIDSLINE MED/9505906; Munakata T
Rassledovanie del o zarazhenii venericheskoi bolezniu i SPIDom : uchebnoe posobie.: Moskva : Ministerstvo vnutrennikh del Rossiiskoi Federatsii, Nauchno-issledovatelskii institut, 1992 66 p (Biblioteka sledovatelia) Unique Identifier : AIDSLINE MED/9511469; Vlasova NA
Sometimes my heart goes numb : love and caregiving in a time of AIDS. 1st ed.: San Francisco : Jossey-Bass Publishers, c1995 xxii, 316 p Unique Identifier : AIDSLINE MED/9612616; Garfield CA; Spring C; Ober D
Women and AIDS : coping and care.: New York : Plenum Press, c1996 xv, 248 p. : ill (AIDS prevention and mental health) Unique Identifier : AIDSLINE MED/9700380; O'Leary A; Jemmott LS
Clinical guidelines for the use of zidovudine therapy in pregnancy to reduce perinatal transmission of HIV. Guidelines for the Use of Zidovudine Therapy in Pregnancy to Reduce Perinatal Transmission of HIV: [Albany, N.Y.] : The Dept., [1994] iv, 25 p Unique Identifier : AIDSLINE MED/9615281
Harvard AIDS review. Fall 1995-: Cambridge, Mass. : Harvard AIDS Institute, [1995- v. : ill Unique Identifier : AIDSLINE MED/9602085
The Hopkins HIV report : a bimonthly newsletter for healthcare providers. Vol. 8, no. 2 (July 1996)-: Baltimore, Md. : Johns Hopkins University Aids Service, Division of Infectious Diseases, [1996- v Unique Identifier : AIDSLINE MED/9614441
Living with HIV : new treatments, new hopes. [videorecording]: [United States] : Information Television Network, c1996 1 videocassette (20 min.) : sd., col. ; 1/2 in (Cutting edge medical report) Unique Identifier : AIDSLINE AV/9615298; Volberding P; (Producer) This program examines the future of treatment for the AIDS/HIV virus, exploring advances in drug therapy, the latest breakthroughs in research, and a discussion of the HIV-2 virus. Featured in the program are highly respected medical professionals in the area of AIDS research: Dr. Michael Saag and Dr. Geor
Update HIV infection : diagnosis and treatment of oral manifestations. [sound recording]: [Chicago, Ill.] : Chicago Dental Society, [1994] 2 sound cassettes : analog Unique Identifier : AIDSLINE AV/9443471; Silverman S
AIDS-Bilanz : Bericht der Bayerischen Staatsregierung uber die bisher durchgefuhrten Massnahmen zur AIDS-Bekampfung (1987-1992).: Munchen : Bayerisches Staatsministerium fur Arbeit und Sozialordnung, Familie, Frauen und Gesundheit, [1994] 136 p Unique Identifier : AIDSLINE CAT/9616431
AIDS : safety, sexuality, and risk.: London ; Bristol, PA : Taylor & Francis, 1995 vii, 232 p. : ill (Social aspects of AIDS) Unique Identifier : AIDSLINE CAT/9613333; Aggleton P; Davies P; Hart G
ATL to AIDS.: Tokyo : Nankodo, 1994 viii, 150 p. : ill (Molecular medicine series) Unique Identifier : AIDSLINE CAT/9501074; Hatanaka M
Witnessing disease : autopathographies of AIDS and syphilis in 16th and 20th century Germany.: [Ithaca, N.Y.? : s.n.], c1992 vii, 188 p Unique Identifier : AIDSLINE CAT/9614289; Hahn RL
Anti-AIDS drug development : challenges, strategies, and prospects.: [Chur, Switzerland?] ; United States : Harwood Academic Publishers, c1995 x, 298 p. : ill Unique Identifier : AIDSLINE CAT/9700251; Mohan P; Baba M
AIDS and the body politic : biomedicine and sexual difference.: London ; New York : Routledge, 1996 xii, 169 p. : ill (Writing corporealities) Unique Identifier : AIDSLINE CAT/9615979; Waldby C
AIDS trauma and support group therapy : mutual aid, empowerment, connection.: New York : Free Press, c1996 ix, 214 p Unique Identifier : AIDSLINE CAT/9618061; Gabriel MA
Book of abstracts : the Fifth European Conference on Clinical Aspects and Treatment of HIV Infection, Copenhagen, Denmark, September 26-29, 1995.: Infection [Hellerup, Denmark : International Conference Services, 1995?] 142 p. : ill Unique Identifier : AIDSLINE CAT/9700239
Counselling in HIV infection and AIDS. 2nd ed.: Oxford ; Cambridge, Mass. : Blackwell Science, 1996 viii, 325 p. : ill Unique Identifier : AIDSLINE CAT/9616178; Green J; McCreaner A
Crossing borders : migration, ethnicity, and AIDS.: London ; Bristol, PA : Taylor & Francis, 1996 xiv, 257 p. : ill (Social aspects of AIDS) Unique Identifier : AIDSLINE CAT/9700441; Haour-Knipe M; Rector R
Health workers and AIDS : research, intervention, and current issues in burnout and response.: [Chur, Switzerland?] ; United States : Harwood Academic Publishers, c1995 xv, 419 p. : ill Unique Identifier : AIDSLINE CAT/9700250; Bennett L; Miller D; Ross MW
HIV a uklad odpornosciowy. Wyd. 2. zmienione.: Krakow : Nakl. Uniwersytetu Jagiellonskiego, 1994 73 p. : ill (Skrypty uczelniane / Uniwersytet Jagiellonski, ISSN 0239-6017 ; nr. 703) Unique Identifier : AIDSLINE CAT/9507194; Plytycz B
HIV/AIDS community information services : experiences in serving both at-risk and HIV-infected populations.: New York : Haworth Press, c1996 144 p (Haworth medical information sources) Unique Identifier : AIDSLINE CAT/9612327; Huber JT
HIV, AIDS, and childbearing : public policy, private lives.: New York : Oxford University Press, 1996 xx, 492 p. : ill Unique Identifier : AIDSLINE CAT/9613474; Faden RR; Kass NE
Nihon no eizu.: Tokyo : Akashi Shoten, 1994 162 p. : ill Unique Identifier : AIDSLINE CAT/9505906; Munakata T
Rassledovanie del o zarazhenii venericheskoi bolezniu i SPIDom : uchebnoe posobie.: Moskva : Ministerstvo vnutrennikh del Rossiiskoi Federatsii, Nauchno-issledovatelskii institut, 1992 66 p (Biblioteka sledovatelia) Unique Identifier : AIDSLINE CAT/9511469; Vlasova NA
Sometimes my heart goes numb : love and caregiving in a time of AIDS. 1st ed.: San Francisco : Jossey-Bass Publishers, c1995 xxii, 316 p Unique Identifier : AIDSLINE CAT/9612616; Garfield CA; Spring C; Ober D
Women and AIDS : coping and care.: New York : Plenum Press, c1996 xv, 248 p. : ill (AIDS prevention and mental health) Unique Identifier : AIDSLINE CAT/9700380; O'Leary A; Jemmott LS
Clinical guidelines for the use of zidovudine therapy in pregnancy to reduce perinatal transmission of HIV.: Guidelines for the Use of Zidovudine Therapy in Pregnancy to Reduce Perinatal Transmission of HIV [Albany, N.Y.] : The Dept., [1994] iv, 25 p Unique Identifier : AIDSLINE CAT/9615281
Harvard AIDS review. Fall 1995-: Cambridge, Mass. : Harvard AIDS Institute, [1995- v. : ill Unique Identifier : AIDSLINE CAT/9602085
The Hopkins HIV report : a bimonthly newsletter for healthcare providers. Vol. 8, no. 2 (July 1996)-: Baltimore, Md. : Johns Hopkins University Aids Service, Division of Infectious Diseases, [1996- v Unique Identifier : AIDSLINE CAT/9614441
International conference on advances in AIDS vaccine development : Third Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS, Oct. 1-5, 1990.: Meeting Bethesda, Md. : The Branch, 1990 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9700811
Intimate details and vital statistics : AIDS, sexuality, and the social order in New Zealand.: Auckland : Auckland University Press, 1996 xiii, 234 p. : ill Unique Identifier : AIDSLINE CAT/9617498; Davis P
Sex, drugs, and viruses in sin city Sydney, 1994 : report of the Australian study of HIV and injecting drug use (ASHIDU).: Sydney : University of New South Wales, National Drug and Alcohol Research Centre, [1996] iv, 80 p. : ill (Technical report / National Drug and Alcohol Research Centre ; no. 37) Unique Identifier : AIDSLINE CAT/9615511; Rutter S
Enhancement of the Th1 cytokine response of bacillus Calmette-Guerin and streptococcal preparation OK-432 (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A3308 1996. Unique Identifier : AIDSLINE ICDB/97633308; Fujimoto T; O'Donnell MA; Mai M; Duda RB; Beth Israel Hosp., Harvard Medical Sch., Boston, MA, 02215; In cancer immunotherapy with biological response modifiers (BRM) such as bacillus Calmette-Guerin (BCG) or streptococcal preparation OK-432, induced interferon-gamma (IFN-gamma) plays a crucial role in the inhibition of tumor growth. This study was undertaken to determine whether additional cytokines would further enh
Immunotherapy of ovarian cancer with t-cell receptor Vbeta-specific, ex vivo-expanded cytotoxic T lymphocytes (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A3339 1996. Unique Identifier : AIDSLINE ICDB/97633339; Oshidari F; Muniappan A; Freedman R; Lebkowski J; Talib S; Applied Immune Sciences Incorporated, Santa Clara, CA 95054; Recognition of tumor-associated antigen in the context of MHC, and subsequent activation of T-lymphocytes, are mediated by the alphabeta heterodimer of the T-cell receptor (TCR). The specificity of a TCR is determined by variable regions of alpha and beta chains (Valpha and Vbeta) and the third complimentary determini
Immune augmentation by an orally active peptide following transplantation for lymphoma (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A3340 1996. Unique Identifier : AIDSLINE ICDB/97633340; Talmadge J; Ino K; Walker S; Heinmann D; Bierman P; Univ. of Nebraska Medical Center, Omaha, NE 68198; Bestatin [(2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl-L-leucine], is an orally-active immune modulator which binds to CD13. Bestatin (Ubenimex) augments immune function, significantly prolongs survival in acute myelogenous leukemia and induces a graft-versus-host effect in allogenic bone marrow transplant (BMT) patients
A polyvalent melanoma vaccine induces a CD8 T-cell response to MART-1 and MAGE-3 peptides (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A3350 1996. Unique Identifier : AIDSLINE ICDB/97633350; Reynolds SR; Vukmanovic S; Oratz R; Shapiro RL; Bystryn J-C; The Ronald O. Perelman Dept. of Dermatology, New York Univ.; Medical Center, New York, NY 10016; Melanoma patients immunized with a polyvalent vaccine were assessed for their peripheral blood lymphocyte (PBL) responses to the melanoma peptides MART-1, MAGE-3 and a control peptide from falciparum malaria. The vaccine was prepared from shed melanoma antigens, bound to alum, and administered sc every 3 weeks x 4 to
Clinical experience in phase I and phase II testing of direct intratumoral administration with allovectin-7: a gene-based immunotherapeutic agent (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A578 1996. Unique Identifier : AIDSLINE ICDB/97635578; Vogelzang NJ; Sudakoff G; Hersh EM; Stopeck A; Rubin J; Galanis E; Schreiber A; Stahl S; University of Chicago, Medical Center, Chicago, IL 60637; We have completed 3 phase I studies to determine the safety of direct intratumoral injection of allovectin-7, an allogeneic MHC class I gene, HLA-B7, in a DNA plasmid formulated with a cationic lipid in 47 (43 evaluable) HLAB7 negative patients (pts) with advanced metastatic melanoma (MM; n=14), colorectal cancer (CC;
Bioactivity of a human GM-CSF tumor vaccine for the treatment of metastatic renal cell carcinoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A585 1996. Unique Identifier : AIDSLINE ICDB/97635585; Jaffee EM; Marshall F; Weber C; Pardoll DM; Levitsky H; Nelson W; Carducci M; Mulligan R; Simons J; The Johns Hopkins School of Medicine, Baltimore, MD 21205; Tumor cells retrovirally transduced to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) induce potent T cell mediated immune responses that can cure mice of 4 pre-established tumor burdens. Based on these findings, a randomized, double-blinded, dose-escalating phase I trial was conducted to compare au
Incidence of Hodgkin's disease (HD) in a cohort of HIV seroconverters (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A847 1996. Unique Identifier : AIDSLINE ICDB/97635847; Serraino D; Pezzotti P; Cozzi Lepri A; Grigoletto E; Tirelli U; Rezza G; Centro di Riferimento Oncologico, 33081 Aviano, Italy; Incidence rates of HD in HIV-infected individuals with known date of seroconversion are an important contribution to evaluate whether an increase of HD due to the AIDS epidemic really exists. This study is part of a larger Italian multicentre investigation aimed at assessing the incidence of AIDS in a cohort of seroco
Fulminant epidemic Kaposi's sarcoma (EKS): hallmark of AIDS in Zimbabwe (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A849 1996. Unique Identifier : AIDSLINE ICDB/97635849; Borok M; Gudza I; Kiire C; Levy L; Otim-Oyet D; Olweny C; Clinch J; Schipper H; University of Zimbabwe, Zimbabwe; A 10-fold increase in the incidence of AIDS associated epidemic Kaposi s sarcoma (EKS) has been observed in Harare, Zimbabwe since 1987. EKS differs from the endemic variety in many ways. It affects a younger age group (mean age 36 years versus 46 years); more females (M:F 4.6:1
Recombinant IL-3 in HIV seropositive patients with cytopenias: effective long-term therapy (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A851 1996. Unique Identifier : AIDSLINE ICDB/97635851; Von Roenn JH; Gordon LI; Grace W; Lee S; Northwestern University, Chicago, IL; HIV-infected patients develop multi-lineage bone marrow suppression which may compromise the ability to deliver optimal therapy for infections and neoplastic diseases. IL-3 is a multi-lineage hematopoietic-growth factor which has been shown in vitro to augment HIV expression in monocytes. We previously reported (ASCO;
Malignancies in the multicenter AIDS cohort study (MACS), 1984-1994 (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A852 1996. Unique Identifier : AIDSLINE ICDB/97635852; Lyter DW; Kingsley LA; Rinaldo CR; Bryant J; Illinois Masonic Cancer Center, Chicago, IL 60657; Since April 1, 1984, 5579 gay men have been followed by the MACS, a prospective study of the natural history of human immunodeficiency virus (HIV) infection. The cohort includes 2896 HIV seronegative (SN) participants and 2683 who were seropositive (SP) at enrollment or who seroconverted during the course of the study
Total pain's evaluation (TPE) in 40 AIDS patients with cancer (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A856 1996. Unique Identifier : AIDSLINE ICDB/97635856; Litovska S; Navigante A; Marantz A; Lewi D; Fernandez Hospital, Buenos Aires, Argentina; Without a cure on the horizon there is a need to identify ways to sustain hope, existential and spiritual well being in pts with AIDS and cancer (Carson V, Perspect Psychiatr Care; 26(2):28-34 1990). Proposal of the method to evaluate the total pain was published in Proc Asco; 11:386 1992. Despite the importance of th
Oral combination chemotherapy (CT) in the treatment of AIDS-associated Hodgkin's disease (HD) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A858 1996. Unique Identifier : AIDSLINE ICDB/97635858; Remick S; Doshi S; Bibighaus M; Eckstein A; Ramnes C; McSharry J; Rustau P; Pearce T; Albany Medical College, Albany, NY; We reported the results of an oral-based combination CT regimen given to patients (pts) with AIDS-related non-Hodgkin s lymphoma repeated at 6 week intervals consisting of CCNU 100 mg/m2 d 1 (odd cycles); VP-16 200 mg/m2 d 1-3; cyclophosphamide 100 mg/m2 and procarbazine 100 mg/m2
Randomized trial of trimetrexate (TMTX), leucovorin (LV) and dapsone (DAP) vs trimethoprim/sulfamethoxazole (T/S) for pneumocystis carinii pneumonia (PCP): clinical and pharmacokinetic results (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A863 1996. Unique Identifier : AIDSLINE ICDB/97635863; Stansell JD; Sattler FR; Dube M; Koda RT; Lee WL; Chaterjee DJ; Sharpe E; Capizzi RL; Kurman MR; Univ. of Southern California, Los Angeles, CA; PCP remains one of the most frequent infections among patients with chronic immunosuppression. TMTX, a non-classical antifol does not use the reduced folate (RF) carrier mechanism to enter cells. Since PCP does not have the RF carrier, TMTX is effective in PCP treatment when given with LV due to selective protection o
Case report with unexpected adverse events in one AIDS related Kaposi's sarcoma treated with beta human chorionic gonadotropin (BETA-HCG) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A867 1996. Unique Identifier : AIDSLINE ICDB/97635867; Yamaguchi NH; Varella D; Guerra CV; Santos MA; Mazuco C; Duarte AJ; Lunardi-Iskandar Y; Bryant J; Gallo AR; Immunology Division, University of Sao Paulo Clinical Hospital,; Sao Paulo, Brazil; AIDS related Kaposi s sarcoma (KS) is commonly observed in HIV infected homobisexual man being sex an independent risk factor. In vitro, KS malignant cells (KS Y-1) were unable to grow when incubated with BETA-HCG (Lunardi-Iskandar et al, Nature; 375:64-8 1995). Injected into the lesions, BETA-HCG induced a tumor regr
Incidence of extranodal lymphoma: a ten-year retrospective analysis (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A1306 1996. Unique Identifier : AIDSLINE ICDB/97636306; Mullai N; Parveez R; Shiomoto G; Allen S; Cook County Hospital, Chicago, IL 60612; A ten-year (1984-1994) retrospective analysis on the incidence of extranodal lymphoma was done at Cook County Hospital (CCH). A total of 378 patients was diagnosed with lymphoma during this period. Non-Hodgkin s lymphoma was reported in 256 patients, of whom 72 presented as extranodal lymphomas. Data are presented in
Large mediastinal mass (LMM) in children with Hodgkin's disease (HD) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A1334 1996. Unique Identifier : AIDSLINE ICDB/97636334; Graziano J; Leonidas J; Lanzkowsky P; Karayalcin G; Albert Einstein College of Medicine at Long Island Jewish Medical; Center, Schneider Children's Hospital, New Hyde Park, NY 11040; We reviewed the records of all patients diagnosed and treated for HD with LMM at Schneider Children s Hospital between 1984-1994. LMM was defined as the maximum transverse width of the mass on PA chest film exceeding 33% of the width of the thoracic cage at its maximum. A total of 27 patients were studied (12 female a
Performance status in clinical oncology: different import in protocol and non-protocol settings (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A1617 1996. Unique Identifier : AIDSLINE ICDB/97636617; Hausner P; Otterson G; Mcelroy K; Curt GA; Medicine Branch, NCI, Bethesda, MD 20892; A 35-year-old male patient with AIDS and pulmonary Kaposi s sarcoma who was started on paclitaxel chemotherapy while in need of respiratory assistance for respiratory failure, and then 2 lived 11+ months, is presented as a case against dogmatic use of performance status (PS) to govern the utilization of non-protocol c
A preliminary evaluation of a combination of interferon alpha and cis-retinoic acid in patients with certain vascular tumors-malignant and benign (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A1695 1996. Unique Identifier : AIDSLINE ICDB/97636695; Burgess MA; Patel SR; Plager C; Raney RB Jr; Benjamin RS; UT M.D. Anderson Cancer Center, Houston, TX 77030; Based upon the antiangiogenic properties of both interferon-alpha (IFN-a) and 13-cis-retinoic acid (CRA), together with the effectiveness of IFN-a against benign (capillary hemangiomas of infancy) and malignant (HIV-related Kaposi s sarcoma) vascular lesions, a combination of IFN-a and CRA was used to treat 16 patient
Malignant tumors in patients with HIV infection.: Crit Rev Oncol Hematol. 1996 Nov;24(3):165-84. Unique Identifier : AIDSLINE MED/97049674; Tirelli U; Errante D; Carbone A; Gloghini A; Vaccher E; Division of Medical Oncology and AIDS, Centro di Riferimento,; Aviano (PN), Italy.
Serum chemokine levels in patients with non-progressing HIV infection.: AIDS. 1996 Aug;10(9):F29-33. Unique Identifier : AIDSLINE MED/97006431; McKenzie SW; Dallalio G; North M; Frame P; Means RT Jr; AIDS Clinical Trial Unit, University of Cincinnati College of; Medicine, Ohio, USA.; OBJECTIVE: To evaluate serum chemokines, macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES, concentrations in non-progressing HIV-infected patients and AIDS patients. SETTING: University Hospital-based AIDS Clinical Trials Unit. DESIGN/METHODS: Serum MIP-1 alpha, MIP-1 beta and RANTES levels were de
Trends in age at AIDS diagnosis in Europe and the United States: evidence of pronounced "ageing' among injecting drug users.: AIDS. 1996 Aug;10(9):1001-7. Unique Identifier : AIDSLINE MED/97006441; Zellweger U; Wang J; Heusser R; Somaini B; Institute for Social and Preventive Medicine, University of; Zurich, Switzerland.; OBJECTIVES: To analyse trends in age at diagnosis for adult AIDS cases reported in Europe and the United States . DESIGN: We used AIDS surveillance data for the seven European countries with the highest cumulative number of AIDS cases reported through June 1994 and for the United States
Prevalence and risk behaviours for HIV infection among inmates of a provincial prison in Quebec City.: AIDS. 1996 Aug;10(9):1009-15. Unique Identifier : AIDSLINE MED/97006442; Dufour A; Alary M; Poulin C; Allard F; Noel L; Trottier G; Lepine D; Hankins C; Research Centre, Saint-Sacrement Hospital, Quebec City, Canada.; OBJECTIVE: To assess HIV prevalence and related risk factors among inmates at the Quebec Detention Centre (QDC). DESIGN: Cross-sectional prevalence study. METHODS: Inmates incarcerated at the QDC in September 1994 were asked to participate in an anonymous survey concerning HIV infection. Volunteers answered a question
Risk factors for intravenous drug use and sharing equipment among young male drug users in Longchuan County, south-west China.: AIDS. 1996 Aug;10(9):1017-24. Unique Identifier : AIDSLINE MED/97006443; Wu Z; Detels R; Zhang J; Duan S; Cheng H; Li Z; Dong L; Huang S; Jia M; Bi X; Department of Epidemiology, University of California Los Angeles; School of Public Health 90095-1772, USA.; OBJECTIVES: To identify the risk factors for intravenous drug use and sharing of equipment in Longchuan County in south-west China . METHODS: Demographic information and sexual and drug-use-related behavior between 1 January 1991 and 1 August 1994 were collected retrospectively from
The international epidemiology of disseminated Mycobacterium avium complex infection in AIDS. International MAC Study Group.: AIDS. 1996 Aug;10(9):1025-32. Unique Identifier : AIDSLINE MED/97006444; Fordham von Reyn C; Arbeit RD; Tosteson AN; Ristola MA; Barber TW; Waddell R; Sox CH; Brindle RJ; Gilks CF; Ranki A; Bartholomew C; Edwards J; Falkinham JO 3rd; O'Connor GT; Infectious Disease Section, Dartmouth-Hitchcock Medical Center,; Lebanon, New Hampshire 03756, USA.; OBJECTIVE: To determine rates of disseminated Mycobacterium avium complex (MAC) infection among AIDS patients in developed and developing countries, and to determine whether different rates reflect differences in exposure or immunity, or both. DESIGN: Prospective cohort study. SETTING: University hospitals and outpati
Psychiatric morbidity on entry to an HIV primary care clinic.: AIDS. 1996 Aug;10(9):1033-9. Unique Identifier : AIDSLINE MED/97006445; Lyketsos CG; Hutton H; Fishman M; Schwartz J; Treisman GJ; AIDS Psychiatry Service, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; OBJECTIVE: To ascertain the prevalence and predictors of psychiatric distress in an inner-city HIV primary care clinic. DESIGN: Cross-sectional study. SETTING: Inner-city adult HIV clinic. PARTICIPANTS: A series of 222 HIV-infected patients newly presenting to the medical clinic for evaluation over a 1-year period. OU
High frequency of invasive cervical cancer among female injecting drug users with AIDS in Italy [letter]: AIDS. 1996 Aug;10(9):1041-2. Unique Identifier : AIDSLINE MED/97006446; Serraino D; Napoli PA; Zaccarelli M; Alliegro MB; Pezzotti P; Rezza G
Replication of HIV-1 in human peripheral blood mononuclear cells activated by exogenous Nef [letter]: AIDS. 1996 Aug;10(9):1042-3. Unique Identifier : AIDSLINE MED/97006447; Torres BA; Tanabe T; Johnson HM
Contribution of prostaglandin E2 to the interleukin-12 defect in HIV-infected patients [letter]: AIDS. 1996 Aug;10(9):1043-5. Unique Identifier : AIDSLINE MED/97006448; Chougnet CA; Margolis D; Landay AL; Kessler HA; Shearer GM
Does dapsone increase mortality when given for prophylaxis of Pneumocystis carinii pneumonia? [letter]: AIDS. 1996 Aug;10(9):1045-6. Unique Identifier : AIDSLINE MED/97006449; Opravil M; Hirschel B; Luthy R
Low-dose dapsone, co-trimoxazole, and survival in Pneumocystis carinii primary prophylaxis [letter]: AIDS. 1996 Aug;10(9):1046-7. Unique Identifier : AIDSLINE MED/97006450; Antinori A; Murri R; Ammassari A
AIDS at a university hospital in Bangkok, Thailand [letter]: AIDS. 1996 Aug;10(9):1047-9. Unique Identifier : AIDSLINE MED/97006451; Ruxrungtham K; Muller O; Sirivichayakul S; Ubolyam S; Teeratakulpisarn S; Hanvanich M; Phanuphak P
Modulation of all-trans-retinoic acid administered on intermittent schedule by alpha-interferon 2a in a patient with AIDS-related Kaposi's sarcoma [letter]: AIDS. 1996 Aug;10(9):1049-50. Unique Identifier : AIDSLINE MED/97006452; Toma S; Iacona I; Palumbo R; Moresco L; Raffo P; Regazzi MB
Minimum effective dose and duration to reverse neutropenia in non-cancer patients with advanced HIV disease [letter]: AIDS. 1996 Aug;10(9):1050-1. Unique Identifier : AIDSLINE MED/97006453; Hermans P; Franchioly P; Thioux C; Gray SJ; Vannerom H; Clumeck N
Trifluorothymidine 0.5% ointment in the treatment of aciclovir-resistant mucocutaneous herpes simplex in AIDS [letter]: AIDS. 1996 Aug;10(9):1051-3. Unique Identifier : AIDSLINE MED/97006454; Amin AR; Robinson MR; Smith DD; Swenson CF; Luque AE
Cytokine network and HIV syncytium-inducing phenotype shift [letter]: AIDS. 1996 Aug;10(9):1053-5. Unique Identifier : AIDSLINE MED/97006455; Torres Y; Medrano FJ; Rey C; Calderon EJ; Sanchez-Quijano A; Lissen E; Leal M
Risk factors associated with Epstein-Barr virus replication in oral epithelial cells of HIV-infected individuals.: AIDS. 1996 Aug;10(9):935-40. Unique Identifier : AIDSLINE MED/97006432; Boulter AW; Soltanpoor N; Swan AV; Birnbaum W; Johnson NW; Teo CG; Royal College of Surgeons, Department of Dental Sciences, King's; College School of Medicine and Dentistry, London, UK.; OBJECTIVE: To examine risk factors associated with Epstein-Barr virus (EBV) replication in the oral epithelium of an HIV-infected cohort. DESIGN: Longitudinal study of behavioural, medication and immunological parameters of HIV-1-seropositive outpatients attending a genitourinary clinic. Outcome measure was EBV DNA po
Distribution of human herpesvirus-8 sequences throughout the spectrum of AIDS-related neoplasia.: AIDS. 1996 Aug;10(9):941-9. Unique Identifier : AIDSLINE MED/97006433; Gaidano G; Pastore C; Gloghini A; Cusini M; Nomdedeu J; Volpe G; Capello D; Vaccher E; Bordes R; Tirelli U; Saglio G; Carbone A; Department of Medical Science, University of Turin, Italy.; OBJECTIVE: AIDS frequently associates with certain malignancies, including Kaposi s sarcoma, non-Hodgkin s lymphoma (NHL), and anogenital neoplasia. In this study we aimed to define the frequency of infection by human herpesvirus (HHV)-8 throughout the spectrum of AIDS-related neop
Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients.: AIDS. 1996 Aug;10(9):951-8. Unique Identifier : AIDSLINE MED/97006434; Cinque P; Vago L; Dahl H; Brytting M; Terreni MR; Fornara C; Racca S; Castagna A; Monforte AD; Wahren B; Lazzarin A; Linde A; Department of Infectious Diseases, University of Milan, Italy.; OBJECTIVE: To assess the diagnostic reliability of polymerase chain reaction (PCR) on cerebrospinal fluid (CSF) for virus-associated opportunistic diseases of the central nervous system (CNS) in HIV-infected patients. DESIGN: CSF samples from 500 patients with HIV infection and CNS symptoms were examined by PCR. In 21
Lack of consistency between five definitions of nonprogression in cohorts of HIV-infected seroconverters.: AIDS. 1996 Aug;10(9):959-65. Unique Identifier : AIDSLINE MED/97006435; Strathdee SA; Veugelers PJ; Page-Shafer KA; McNulty A; Moss AR; Schechter MT; van Griensven GJ; Coutinho RA; Department of Health Care and Epidemiology, University of British; Columbia, St Paul's Hospital, Vancouver, Canada.; OBJECTIVE: To identify appropriate criteria for characterizing HIV-infected nonprogressors. DESIGN: Five definitions were compared as follows: (1) last CD4 count > 500 x 10(6)/l; (2) two most recent CD4 counts > 500 x 10(6)/l; (3) calculated CD4 count based on linear regression > 500 x 10(6)/l; (4) CD4 slope > or = 0
Beta-carotene in HIV infection: an extended evaluation.: AIDS. 1996 Aug;10(9):967-73. Unique Identifier : AIDSLINE MED/97006436; Coodley GO; Coodley MK; Lusk R; Green TR; Bakke AC; Wilson D; Wachenheim D; Sexton G; Salveson C; Division of Internal Medicine, Oregon Health Sciences University,; Portland 97201-3098, USA.; OBJECTIVE: Several small short-term intervention studies have suggested that beta-carotene supplementation in HIV-infected patients can increase the number of various immune cells including CD4 cells. This prospective double-blinded study was designed to investigate whether beta-carotene supplementation would result i
Drug resistance and virologic response in NUCA 3001, a randomized trial of lamivudine (3TC) versus zidovudine (ZDV) versus ZDV plus 3TC in previously untreated patients.: AIDS. 1996 Aug;10(9):975-81. Unique Identifier : AIDSLINE MED/97006437; Kuritzkes DR; Quinn JB; Benoit SL; Shugarts DL; Griffin A; Bakhtiari M; Poticha D; Eron JJ; Fallon MA; Rubin M; Division of Infectious Diseases, University of Colorado Health; Sciences Center, Denver 80262, USA.; OBJECTIVE: To study the effect of HIV-1 resistance to lamivudine ( 3TC ) and zidovudine (ZDV), and syncytium-inducing (SI) phenotype on virologic response to treatment with ZDV, 3TC, or ZDV plus 3TC in previously untreated individuals with HIV-1 infecti
Dysregulation of the polymorphonuclear leukocyte--Candida spp. interaction in HIV-positive patients.: AIDS. 1996 Aug;10(9):983-7. Unique Identifier : AIDSLINE MED/97006438; Wenisch C; Parschalk B; Zedwitz-Liebenstein K; Graninger W; Rieger A; Department of Infectious Diseases, University Hospital of Vienna,; Austria.; OBJECTIVE: In HIV-infected patients there is an increased frequency of fungal infections. Dysregulation of the response of phagocytic cells to fungal pathogens may be involved. DESIGN: Phagocytosis of Candida spp., consecutive intracellular production of reactive oxygen species, and candicidal activity were analysed i
Faecal tumour necrosis factor-alpha in individuals with HIV-related diarrhoea.: AIDS. 1996 Aug;10(9):989-94. Unique Identifier : AIDSLINE MED/97006439; Sharpstone DR; Rowbottom AW; Nelson MR; Lepper MW; Gazzard BG; Department of HIV/Genitourinary Medicine, Chelsea and Westminster; Hospital, London, UK.; OBJECTIVE: HIV-related gastrointestinal infection is associated with diarrhoea, weight loss, mucosal inflammation and increased intestinal permeability. As tumour necrosis factor (TNF)-alpha may mediate these features this cytokine was measured in the faeces of HIV-seropositive individuals with diarrhoea to assess its
Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538).: AIDS. 1996 Aug;10(9):995-9. Unique Identifier : AIDSLINE MED/97006440; Schmit JC; Ruiz L; Clotet B; Raventos A; Tor J; Leonard J; Desmyter J; De Clercq E; Vandamme AM; Rega Institute for Medical Research, Catholic University of; Leuven, Belgium.; OBJECTIVE: To define genotypic and phenotypic resistance patterns following prolonged therapy with the protease inhibitor ritonavir (ABT-538). DESIGN: Seven HIV-1-infected patients, all but one previously treated with dideoxynucleoside analogues (zido
Use of Culture Care Theory with Baganda women as AIDS caregivers.: J Transcult Nurs. 1996 Jan-Jun;7(2):14-20. Unique Identifier : AIDSLINE MED/97105729; MacNeil JM; In Uganda , AIDS patients are increasingly cared for at home by women in their traditional role of family caregiver. This transcultural nursing study utilized Leininger s (1991) Culture Care Theory to discover the meanings, patterns, and expressions of AIDS caregiving for Baganda wo
Selective effects of electrostatic changes in the CD4 CDR-3-like loop on infection by different human immunodeficiency virus type 1 isolates.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1001-13. Unique Identifier : AIDSLINE MED/96424755; Signoret N; Blanc-Zouaoui D; Kwong PD; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, France.; The role of the CDR-3-like loop of the first domain of the CD4 molecule in infection by the human immunodeficiency virus type 1 (HIV-1) is controversial. In an attempt to determine whether the strong negative charge in the CDR-3-like loop influences HIV-1 infection we have substituted by mutagenesis negative for posit
Altered CD4 interactions of HIV type 1 LAI variants selected for the capacity to induce membrane fusion in the presence of a monoclonal antibody to domain 2 of CD4.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1015-21. Unique Identifier : AIDSLINE MED/96424756; Klasse PJ; Sattentau QJ; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.; We selected HIV-1-LAI variants with the ability to induce syncytium formation of C8166 cells in the presence of a monoclonal antibody (MAb), 5A8, to domain 2 of CD4. Five biologically cloned variants with at least 60-fold greater resistance than wild type to 5A8-mediated inhibition of syncytium formation were obtained
Further insights on the inhibition of HIV type 1 infection in vitro by CD4-modified synthetic peptides containing phenylalanine.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1023-30. Unique Identifier : AIDSLINE MED/96424757; Prieto I; Lasarte JJ; Sarobe P; Golvano J; Civeira MP; Gullon A; Prieto J; Borras-Cuesta F; Departamento de Medicina Interna, Facultad de Medicina,; Universidad de Navarra, Pamplona, Spain.; Phenylalanine-containing peptides from CD4 were synthesized on the basis of chemical similarity with active CD4(81-92)-benzylated peptides. Systematic replacement of amino acids of these peptides bearing the benzyl group by phenylalanine, afforded several peptides that were able to block the binding of gp120 to CD4 an
Role of HLA class I in HIV type 1-induced syncytium formation.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1031-40. Unique Identifier : AIDSLINE MED/96424758; de Santis C; Robbioni P; Longhi R; Carrow E; Siccardi AG; Beretta A; DIBIT, S. Raffaele Scientific Institute, Milan, Italy.; Neutralization of HIV-1 in vitro by anti-HLA class I antibodies suggests that class I molecules are involved in HIV-1 infection. HIV-infected cells can fuse with uninfected cells in a process that leads to the formation of multinucleated syncytia, involving an interaction between host and viral antigens expressed at t
In vitro effects of anti-HIV immunotoxins directed against multiple epitopes on HIV type 1 envelope glycoprotein 160.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1041-51. Unique Identifier : AIDSLINE MED/96424759; Pincus SH; Wehrly K; Cole R; Fang H; Lewis GK; McClure J; Conley AJ; Wahren B; Posner MR; Notkins AL; Tilley SA; Pinter A; Eiden L; Teintze M; Dorward D; Tolstikov VV; Laboratory of Microbial Structure and Function, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, Hamilton, Montana 59840, USA.; We have used a panel of anti-gp160 MAbs to construct anti-HIV immunotoxins by coupling antibodies to ricin A chain (RAC). The ability of the immunotoxins to kill HIV-1-infected cells and halt the spread of infection was tested in tissue culture on persistently and acutely infected cell lines and primary lymphocyte cul
Type 1 cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1053-61. Unique Identifier : AIDSLINE MED/96424760; Clerici M; Balotta C; Meroni L; Ferrario E; Riva C; Trabattoni D; Ridolfo A; Villa M; Shearer GM; Moroni M; Galli M; Cattedra di Immunologia, Universita degli Studi di Milano,; Ospedale L. Sacco, Italy.; Cytokine production, prevalence of viral isolation, and surface marker expression of peripheral blood mononuclear cells (PBMCs) were analyzed in HIV+ individuals with different patterns of disease progression to establish correlations between these parameters. Thus, mitogen-stimulated in vitro production of interferon
Immunological correlates of disease severity in pediatric slow progressors with human immunodeficiency virus type 1 infection.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1063-8. Unique Identifier : AIDSLINE MED/96424761; Patarca R; Sandler D; Maher K; Hutto C; Martin NL; Klimas NG; Scott GB; Fletcher MA; E.M. Papper Laboratory of Clinical Immunology, Department of; Medicine, University of Miami School of Medicine, Florida 33101,; USA.; Pediatric slow progressors are a group of HIV-1-infected individuals who are homogeneous for route and length of infection and standard of care and are therefore amenable to cross-sectional population studies on the immunological correlates of disease progression. We report here that both clinical and immunological ca
Spread of HIV type 1 in Slovakia remains limited and is restricted to subtype B.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1069-71. Unique Identifier : AIDSLINE GENBANK/U53203; Zachar V; Mayer V; Zacharova V; Schmidtmayerova H; Kasanicka J; Mokras M; Liu X; Goustin AS; Ebbesen P; Department for Virus and Cancer Research, Danish Cancer Society,; Aarhus C, Denmark.
In vivo and in vitro sequence diversity of the V3 env region of HIV type 1 from the Ivory Coast.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):1073-5. Unique Identifier : AIDSLINE +; Audoly G; Fillon S; Pinay P; Desgranges C; Unite 271 INSERM, Lyon, France.
Perspective: research highlights at the Albert Einstein College of Medicine Center for AIDS research. Approaches to control drug resistance in HIV: the role of increased polymerase fidelity.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):959-63. Unique Identifier : AIDSLINE MED/96424749; Prasad VR; Drosopoulos WC; Hamburgh ME; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, New York 10461, USA.
Use of floxuridine to modulate the antiviral activity of zidovudine.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):965-8. Unique Identifier : AIDSLINE MED/96424750; Medina DJ; Tung PP; Sathya B; Strair RK; Cancer Institute of New Jersey, Robert Wood Johnson School of; Medicine, University of Medicine and Dentistry of New Jersey,; Piscataway 08854, USA.
The role of HIV type 1 phenotype and genotype in long-term responders to zidovudine therapy.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):969-75. Unique Identifier : AIDSLINE MED/96424751; Angarano G; Monno L; Vivirito MC; Appice A; Romanelli C; Giannelli A; La Grasta L; Fracasso C; Fiore JR; Milazzo F; Clinic of Infectious Diseases, University of Bari, Italy.; We performed a cross-sectional and partly retrospective virological evaluation of 31 long-term responders (LTRs) to zidovudine (ZDV) (persistent increase in the CD4+ cell counts without progression of HIV infection throughout a period of ZDV therapy > 3 years) and 17 well-matched controls who developed a marked immuno
Quantitative analysis of the endogenous reverse transcriptase reactions of HIV type 1 variants with decreased susceptibility to azidothymidine and nevirapine.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):977-83. Unique Identifier : AIDSLINE MED/96424752; Krogstad P; Chen IS; Canon J; Rey O; Department of Pediatrics, University of California at Los; Angeles, School of Medicine 90095, USA.; A large number of nucleoside analog and nonnucleoside inhibitors of HIV-1 reverse transcriptase (RT) have been developed for clinical use. Data confirm that resistant variants of HIV-1 rapidly emerge in response to the selective pressure of treatment with these agents. Detection of drug resistance generally involves d
Multiple immunizations with attenuated poxvirus HIV type 2 recombinants and subunit boosts required for protection of rhesus macaques.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):985-92. Unique Identifier : AIDSLINE MED/96424753; Myagkikh M; Alipanah S; Markham PD; Tartaglia J; Paoletti E; Gallo RC; Franchini G; Robert-Guroff M; Laboratory of Tumor Cell Biology, DBS, NCI, NIH, Bethesda,; Maryland 20892-4255, USA.; Vaccine protocols involving multiple immunizations with molecularly attenuated vaccinia virus (NYVAC) or naturally attenuated canarypox virus (ALVAC) HIV-2 recombinants and subunit boosts have conferred longlasting protection against HIV-2 infection of macaques. Similar complex protocols using HIV-1 NYVAC and ALVAC re
Protection against mucosal SIVsm challenge in macaques infected with a chimeric SIV that expresses HIV type 1 envelope.: AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):993-9. Unique Identifier : AIDSLINE MED/96424754; Quesada-Rolander M; Makitalo B; Thorstensson R; Zhang YJ; Castanos-Velez E; Biberfeld G; Putkonen P; Swedish Institute for Infectious Disease Control, Karolinska; Institute, Stockholm, Sweden.; In a monkey model we used a chimeric SIV expressing the HIV-1 envelope gene (SHIV-4) as a live attenuated vaccine and a virulent SIVsm as a mucosal challenge. Four cynomolgus monkeys were inoculated intravenously with SHIV-4. Virus was repeatedly isolated from blood mononuclear cells of all four animals for 2 to 7 mon
Nested polymerase chain reaction primers that distinguish between SIVSM and HIV type 2.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1077-9. Unique Identifier : AIDSLINE MED/97000982; Walther L; Grankvist O; Putkonen P; Biberfeld G; Thorstensson R; Swedish Institute for Infectious Disease Control, Karolinska; Institute, Stockholm, Sweden.
Overexpression and purification of a recombinant chimeric HIV type 2/HIV type 1 envelope peptide and application in an accelerated immunobased HIV type 1/2 antibody detection system (AIBS): a new rapid serological screening assay.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1081-91. Unique Identifier : AIDSLINE MED/97000983; Ecker B; Vollenhofer S; Bares T; Schalkhammer T; Schinkinger M; Pittner F; University of Vienna, Institute of Biochemistry and Molecular; Cell Biology, Austria.; A chimeric HIV-2/HIV-1 envelope sequence containing an immunodominant region of HIV-2 gp36 and the corresponding region of HIV-1 gp41 was constructed and overexpressed in Escherichia coli. The recombinant product (rp21/18) was purified and applied in a novel antibody-screening assay. Characteristics in the design of t
TAR- and Tat-independent replication of human immunodeficiency virus type 1 in human hepatoma cells.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1093-101. Unique Identifier : AIDSLINE MED/97000984; Zhu M; Duan L; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107, USA.; The molecular mechanisms involved in the regulation of human immunodeficiency virus type 1 (HIV-1) replication may differ in various cell types and with various exogenous stimuli. TAR/Tat interactions play important roles in HIV-1-long terminal repeat (LTR)-directed transcription, and have become specific targets in m
Models of HIV type 1 proviral gene expression in wild-type HIV and MLV/HIV transgenic mice.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1103-16. Unique Identifier : AIDSLINE MED/97000985; Dickie P; Gazzinelli R; Chang LJ; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0460, USA.; Two proviral HIV transgenic mouse models, one bearing wild-type HIV proviral DNA and the other a modified provirus in which the viral LTRs contained the core enhancer of the Moloney murine leukemia virus (MLV), were compared. The MLV/HIV chimeric LTR, in which the MLV enhancer replaced the NF-kappa B-binding motifs, w
Point mutant frequencies in the pol gene of human immunodeficiency virus type 1 are two- to threefold lower than those of env.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1117-28. Unique Identifier : AIDSLINE +; Quinones-Mateu ME; Holguin A; Dopazo J; Najera I; Domingo E; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM),; Universidad Autonoma de Madrid, Spain.; Nucleotide sequences have been determined for the HIV-1 genomic regions encoding codons 41-108 and 181-219 of reverse transcriptase (RT) (pol gene), and codons 198-331 of gp120 (the C2V3 domains; env gene). Eighty-one HIV-1 samples from patients treated or untreated with RT inhibitors were used to sequence pol and 28
HIV-specific cellular and humoral immune responses in primary HIV infection.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1129-40. Unique Identifier : AIDSLINE MED/97000987; Connick E; Marr DG; Zhang XQ; Clark SJ; Saag MS; Schooley RT; Curiel TJ; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80220, USA.; Primary human immunodeficiency virus (HIV) infection is characterized by a high-titer viremia that declines precipitously within weeks, most likely as a result of host immune responses. Peripheral blood mononuclear cells (PBMCs) and plasma of four recently HIV-infected individuals were examined to assess the humoral a
Differential production of interleukin 10 during human immunodeficiency virus infection.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1141-9. Unique Identifier : AIDSLINE MED/97000988; Chehimi J; Ma X; Chouaib S; Zyad A; Nagashunmugam T; Wojcik L; Chehimi S; Nissim L; Frank I; Division of Allergy, Immunology, and Infectious Diseases,; Children's Hospital of Philadelphia, Pennsylvania 19104, USA.; Interleukin 10, a product of T and B cells and monocytes, displays many Th2-like properties through inhibition of Th1 cell functions. Interleukin 10 is thought to play a major role in the immune dysfunction seen in HIV-infected individuals. In this study, we evaluated in detail the production of IL-10 during HIV infec
Lack of in vivo effect of granulocyte-macrophage colony-stimulating factor on human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1151-9. Unique Identifier : AIDSLINE MED/97000989; Scadden DT; Pickus O; Hammer SM; Stretcher B; Bresnahan J; Gere J; McGrath J; Agosti JM; Division of Hematology/Oncology, New England Deaconess Hospital,; Harvard Medical School, Boston, Massachusetts 02215, USA.; Neutropenia complicates HIV disease or its treatment in a large proportion of patients. Hematopoietic growth factor support has been tested in a number of clinical settings in HIV disease and has been demonstrated to be of benefit for specific parameters. One consideration regarding the use of hematopoietic growth fac
Inhibition of replication of fresh HIV type 1 patient isolates by a polypurine tract-specific self-complementary oligodeoxynucleotide.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1161-8. Unique Identifier : AIDSLINE MED/97000990; Jendis J; Strack B; Volkmann S; Boni J; Molling K; Institut fur Medizinische Virologie, Universitat Zurich,; Switzerland.; A previously described self-complementary oligodeoxynucleotide termed triplex-forming oligodeoxynucleotide (TFO A), 54 bases in length, designed against the polypurine tract of HIV-1 RNA, inhibited viral replication at a 1 to 3 microM concentration in acutely infected cells, whereas antisense and scrambled sequence ol
A model for alignment of Env V1 and V2 hypervariable domains from human and simian immunodeficiency viruses.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1169-78. Unique Identifier : AIDSLINE MED/97000991; Lamers SL; Sleasman JW; Goodenow MM; Department of Pathology, Immunology, and Laboratory Medicine,; University of Florida College of Medicine, Gainesville; 32610-0275, USA.; HIV-1 env gene encodes a multifunctional glycoprotein that is involved in virus infectivity, interactions between the virus and the host immune system, and phenotypic characteristics of virus isolates in culture. A number of Env functions map by genetic analysis to V3, one of five hypervariable domains that compose th
Evidence for HIV type 1 strains of U.S. intravenous drug users as founders of AIDS epidemic among intravenous drug users in northern Europe.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1179-83. Unique Identifier : AIDSLINE GENBANK/L76863; Lukashov VV; Kuiken CL; Vlahov D; Coutinho RA; Goudsmit J; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.; To establish an epidemiological link between HIV-1 epidemics in U.S. and European homosexual men and intravenous drug users (IVDUs) we analyzed the HIV-1 gp120 V3 sequences in both risk groups. Signature pattern analysis revealed that the V3 sequences of viruses from IVDUs in Northern Europe are distinguishable from t
Prevalence of HTLV type I infection in Iran: a serological and genetic study.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1185-90. Unique Identifier : AIDSLINE MED/97000993; Safai B; Huang JL; Boeri E; Farid R; Raafat J; Schutzer P; Ahkami R; Franchini G; Department of Dermatology, New York Medical College, Valhalla; 10595, USA.; Several publications describe the presence of the human T cell lymphotropic virus type I (HTLV-I) in Jewish individuals born in Mash-had, Iran . We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area:
Conference summary: pathogenic mechanisms of HIV type 1-associated neurological syndromes.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1191-4. Unique Identifier : AIDSLINE MED/97000994; Chiodi F; Britton S; Elovaara I; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.
Sequential change of cysteine residues in hypervariable region 1 of glycoprotein 120 in primary HIV type 1 isolates of subtype B.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1195-7. Unique Identifier : AIDSLINE GENBANK/U60161; Wang WK; Mayer KH; Essex M; Lee TH; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.
Envelope glycoprotein 120 sequences of primary HIV type 1 isolates from Pune and New Delhi, India.: AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1199-202. Unique Identifier : AIDSLINE GENBANK/U31364; Tripathy S; Renjifo B; Wang WK; McLane MF; Bollinger R; Rodrigues J; Osterman J; Tripathy S; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.
HIV risk behavior, street outreach, and condom use in eight high-risk populations.: AIDS Educ Prev. 1996 Jun;8(3):191-204. Unique Identifier : AIDSLINE MED/96400573; Anderson JE; Cheney R; Clatts M; Faruque S; Kipke M; Long A; Mills S; Toomey K; Wiebel W; Behavioral and Intervention Research Branch, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA.; In this paper we examine risk behavior, exposure to street outreach, and condom use in samples of injecting drug users (IDUs) and high-risk youth. We used systematic sampling methods to produce representative samples of injecting drug users IDUs (five sites) and high-risk youth (three sites). The populations surveyed
Male bisexual behavior and HIV risk in the United States: synthesis of research with implications for behavioral interventions.: AIDS Educ Prev. 1996 Jun;8(3):205-25. Unique Identifier : AIDSLINE MED/96400574; Doll LS; Beeker C; HIV, STD, & Tuberculosis Prevention, Centers for Disease Control; and Prevention, Atlanta, GA 30333, USA.; This paper reviews recent literature on male bisexuality and HIV risk and suggests new directions for intervention and research in the United States . AIDS case reports and behavioral studies based on convenience samples suggest that behaviorally bisexual men use condoms inconsistently
HIV risk correlates among non-injection cocaine dependent men in treatment.: AIDS Educ Prev. 1996 Jun;8(3):226-35. Unique Identifier : AIDSLINE MED/96400575; Malow RM; Ireland SJ; Department of Psychiatry and Behavioral Sciences, University of; Miami, FL 33136, USA.; Guided by the AIDS Risk Reduction Model (ARRM), psychosocial correlates of HIV risk behavior were examined among noninjection cocaine dependent, heterosexual men (NI-CD-HM) in treatment. Subjects (N = 111) completed a structured interview to measure ARRM mediating variables and HIV risk behaviors. The results indicate
HIV risks and risk reduction readiness in hard-to-reach, drug-using African American and Mexican American women: an exploratory study.: AIDS Educ Prev. 1996 Jun;8(3):236-46. Unique Identifier : AIDSLINE MED/96400576; Turner NH; Solomon DJ; School of Allied Health Sciences, Department of Health Promotion; and Gerontology, University of Texas Medical Branch, Galveston; 77555-1028, USA.; In an exploratory study of the HIV risk-taking behaviors and risk reduction readiness of a sample of 74 hard-to-reach, out-of-treatment African American and Mexican American drug-using women who are at high risk for HIV infection, Mexican American women were found to be more likely than African American women to have
Understanding why heterosexual adults do not practice safer sex: a comparison of two samples.: AIDS Educ Prev. 1996 Jun;8(3):247-57. Unique Identifier : AIDSLINE MED/96400577; Kusseling FS; Shapiro MF; Greenberg JM; Wenger NS; Department of Medicine, University of California, Los Angeles.; We assessed why heterosexually active adults did not have safer sex with their last sexual partner. Subjects enrolled in HIV education and testing trials at a sexually transmitted disease (STD) clinic and a university student health service (SHS) completed questionnaires about their last sexual partner s risk factore
Examination of the relationship between African American adolescents' condom use at sexual onset and later sexual behavior: implications for condom distribution programs.: AIDS Educ Prev. 1996 Jun;8(3):258-66. Unique Identifier : AIDSLINE MED/96400578; Lawrence JS; Scott CP; Community Health Program, Jackson State University, MS; 39217-0105, USA.; School-based condom distribution programs have generated considerable controversy across the country. In the present study 249 sexually active African American adolescents who did (n = 119) and did not (n = 130) use a condom during their initial sexual experience were compared to assess whether condom use at the onsete
AIDS knowledge, teaching comfort, and support for AIDS education among school teachers: a statewide survey.: AIDS Educ Prev. 1996 Jun;8(3):267-77. Unique Identifier : AIDSLINE MED/96400579; Boscarino JA; DiClemente RJ; Outcomes Research Department, Sisters of Charity of Nazareth; Health System, Louisville, KY 40232-4037, USA.; With development of an effective HIV vaccine still elusive (Blower & McLean 1994; McLean & Blower 1993), the control of HIV infection may depend on our ability to successfully educate diverse groups of adolescents in different communities about homosexuality and other sensitive subject matter. A statewide surve
Pathogenesis of AIDS--related Kaposi's sarcoma.: Oncology (Huntingt). 1996 Mar;10(3):335-41; discussion: 342-50. Unique Identifier : AIDSLINE MED/96417657; Emmanoulides C; Miles SA; Mitsuyasu RT; Division of Hematology-Oncology, UCLA Center for Clinical AIDS; Research and Education, University of California, Los Angeles,; USA.; The occurrence of Kaposi s sarcoma (KS) in patients with HIV infection is more than 7,000 times higher than in the non-HIV infected population. The reason for this association is unclear but may involve decreased immune surveillance as a result of the profound cellular immune deficiency caused by HIV, a sexually trans
Isolation of new transmissible herpesvirus suggests additional therapeutic approaches for KS [news]: Oncology (Huntingt). 1996 Mar;10(3):423-4. Unique Identifier : AIDSLINE MED/96417666
A review of the aetiology of squamous cell carcinoma of the conjunctiva.: Br J Cancer. 1996 Nov;74(10):1511-3. Unique Identifier : AIDSLINE MED/97086638; Newton R; Imperial Cancer Research Fund, Cancer Epidemiology Unit,; Radcliffe Infirmary, Oxford, UK.; Squamous cell carcinoma of the conjunctiva is a rare tumour with a multifactorial aetiology. There is strong epidemiological evidence that exposure to solar ultraviolet radiation is an important cause and that HIV infection predisposes to its development. The role of other factors, such as human papillomavirus infecti
Findings fuel HIV fears [news]: Nurs Stand. 1996 Aug 28;10(49):14. Unique Identifier : AIDSLINE MED/97106423; Chinnock P
Confidential business.: Nurs Stand. 1996 Aug 28;10(49):54. Unique Identifier : AIDSLINE MED/97106433; Cox C
A shadow from the past: tuberculosis today (continuing education credit).: Nurs Stand. 1996 Sep 25;11(1 Suppl Nu):5-18; quiz 21-5. Unique Identifier : AIDSLINE MED/97086038; Gleissberg G
Screening for HIV in antenatal clinics [editorial; comment]: Br J Obstet Gynaecol. 1996 Nov;103(11):viii. Unique Identifier : AIDSLINE MED/97074560; Grant JM
Antenatal testing for HIV: to opt in or opt out, that is the question.: Br J Obstet Gynaecol. 1996 Nov;103(11):1059-60. Unique Identifier : AIDSLINE MED/97074561; Smith JR; Barton SE; Boag FC; Steer PJ; Department of Obstetrics and Gynaecology, Chelsea and Westminster; Hospital, London.
Sexual risk behaviour in women carriers of Mycoplasma hominis.: Br J Obstet Gynaecol. 1996 Nov;103(11):1124-8. Unique Identifier : AIDSLINE MED/97074574; Elshibly S; Kallings I; Hellberg D; M~ardh PA; Institute of Clinical Bacteriology, Uppsala University, Sweden.; OBJECTIVE: To study the sexual behaviour of women harbouring Mycoplasma hominis in the vagina. SETTING: Two family planning clinics and a youth clinic for contraceptive advice. METHODS: The vaginal flora of 996 women were investigated microbiologically, including culturing for M. hominis from the posterior vaginal for
Voluntary universal antenatal HIV testing [see comments]: Br J Obstet Gynaecol. 1996 Nov;103(11):1129-33. Unique Identifier : AIDSLINE MED/97074575; Mercey D; Helps BA; Copas A; Petruckevitch A; Johnson AM; Spencer J; Academic Department of Genitourinary Medicine, University College; London Medical School, UK.; OBJECTIVES: To assess the uptake of universal voluntary named HIV testing of hospital booked antenatal women and to identify behavioural and demographic factors associated with testing. To identify the number of previously undiagnosed women detected by the new policy and to compare prevalence among those testing with
A reiterative mode of DNA synthesis adopted by HIV-1 reverse transcriptase after a misincorporation.: Biochemistry. 1996 Nov 26;35(47):14970-83. Unique Identifier : AIDSLINE MED/97098122; Ricchetti M; Buc H; Unite de Physicochimie des Macromolecules Biologiques (URA 1149; du CNRS), Institut Pasteur, Paris, France.; Amplification of oligonucleotide repeats is a major cause of variability and instability of genomes. This phenomenon is probably due to an aberration in the copying process of polymerases. We show here that in the presence of MnCl2, mismatch formation commits HIV-1 reverse transcriptase to a new mode of DNA synthesis
Quantitative analysis of 3'-azido-3'-deoxythymidine incorporation into DNA in human colon tumor cells.: Bioconjug Chem. 1995 Sep-Oct;6(5):536-40. Unique Identifier : AIDSLINE MED/96113584; Sharma M; Jain R; Ionescu E; Darnowski JW; Department of Biophysics, Roswell Park Cancer Institute, Buffalo,; New York 14263, USA.; We have previously reported that 3 -azido-3 -deoxythymidine ( AZT ) can possess significant antineoplastic activity in vitro and in vivo when combined with agents which inhibit de novo thymidylate synthesis. Under these conditions cytotoxicity is closel
Synthesis and antiviral activity of peptide-oligonucleotide conjugates prepared by using N alpha-(bromoacetyl)peptides.: Bioconjug Chem. 1995 Sep-Oct;6(5):573-7. Unique Identifier : AIDSLINE MED/96113589; Arar K; Aubertin AM; Roche AC; Monsigny M; Mayer R; Laboratoire de Biochimie des Glycoconjugues, CNRS, Orleans,; France.; Antisense oligonucleotides represent an interesting tool for selective inhibition of gene expression. In order to direct oligonucleotides to specific compartments within the cell, we have investigated the possibility of coupling them to a signal peptide Lys-Asp-Glu-Leu (KDEL). This sequence should be able to convey ol
Intra- and extracellular immunization against HIV-1 infection with lymphocytes transduced with an AAV vector expressing a human anti-gp120 antibody.: Hum Gene Ther. 1996 Aug 20;7(13):1515-25. Unique Identifier : AIDSLINE MED/97018136; Chen JD; Yang Q; Yang AG; Marasco WA; Chen SY; Department of Cancer Biology, Bowman Gray School of Medicine,; Wake Forest University, Winston-Salem, NC 27006, USA.; Recently, we developed a novel anti-HIV-1 approach by transducing an anti-gp120 antibody gene into lymphocytes, resulting in the resistance to HIV-1 infection by the combined intra- and extracellular binding activities of the neutralizing antibody. To extend this study, we improved the co-expression of the heavy and l
RANTES secretion by gene-modified tumor cells results in loss of tumorigenicity in vivo: role of immune cell subpopulations.: Hum Gene Ther. 1996 Aug 20;7(13):1545-53. Unique Identifier : AIDSLINE MED/97018139; Mule JJ; Custer M; Averbook B; Yang JC; Weber JS; Goeddel DV; Rosenberg SA; Schall TJ; Surgery Branch, National Cancer Institute, National Institutes of; Health, Bethesda, MD 20892, USA.; An immunogenic murine fibrosarcoma cell line was genetically modified to express and produce the human RANTES chemokine stably. In in vitro chemotaxis assays purified recombinant human RANTES as well as human RANTES secreted by the modified murine tumor cells were strongly chemoattractant for mouse CD8+ /Thy-1+ tumor-
Determination of the HIV protease inhibitor BILA 2185 BS in rat plasma by liquid-liquid extraction and high performance liquid chromatography photodiode array detector.: J Pharm Biomed Anal. 1995 Dec;14(1-2):151-4. Unique Identifier : AIDSLINE MED/96430895; Liard F; Ghiro E; Paris W; Yoakim C; Department of Pharmacology, Bio-Mega/Boehringer Ingelheim; Research Inc., Laval, Quebec, Canada.; A novel series of hydroxyethylamine-based inhibitors of HIV protease which contain a substituted pipecolinic amide were developed. After preliminary screening, a representative of this series, compound BILA 2185 BS, demonstrated an IC50 value of 3.3 nM in the enzymatic assay and an EC50 value of 2.0 nM in cell culture
Determination of BMS-186318 in dog, rat and monkey plasma by liquid chromatography-ionspray mass spectrometry.: J Pharm Biomed Anal. 1995 Dec;14(1-2):43-8. Unique Identifier : AIDSLINE MED/96430883; Jemal M; Hawthorne D; Department of Metabolism and Pharmacokinetics, Bristol-Myers; Squibb Pharmaceutical Research Institute, Princeton, NJ; 08543-4500, USA.; BMS-186318 is a member of the recently discovered aminodiol class of HIV protease inhibitors . A simple but sensitive method was developed for the determination of BMS-186318 in dog plasma and then applied to monkey and rat plasma. The compound was extracted from d
HIV seroprevalence among Atlanta's homeless.: J Health Care Poor Underserved. 1996 May;7(2):83-93. Unique Identifier : AIDSLINE MED/97089476; Paris NM; East RT; Toomey KE
Community-acquired pneumonia in a cohort of former injection drug users with and without human immunodeficiency virus infection: incidence, etiologies, and clinical aspects.: Clin Infect Dis. 1996 Jul;23(1):107-13. Unique Identifier : AIDSLINE MED/96412892; Boschini A; Smacchia C; Di Fine M; Schiesari A; Ballarini P; Arlotti M; Gabrielli C; Castellani G; Genova M; Pantani P; Lepri AC; Rezza G; San Patrignano Centro Medico, Rimini, Italy.; Although the association among bacterial pneumonia, human immunodeficiency virus (HIV) infection, and injection-drug use seems to have been well established, accurate estimates of the risk of community-acquired pneumonia among HIV-positive and HIV-negative injection-drug users (IDUs) are still needed. To estimate the
Enterocytozoon bieneusi as a cause of chronic diarrhea in a heart-lung transplant recipient who was seronegative for human immunodeficiency virus.: Clin Infect Dis. 1996 Jul;23(1):114-7. Unique Identifier : AIDSLINE MED/96412893; Rabodonirina M; Bertocchi M; Desportes-Livage I; Cotte L; Levrey H; Piens MA; Monneret G; Celard M; Mornex JF; Mojon M; Departement de Parasitologie et de Mycologie, Universite; Claude-Bernard, Lyon, France.; Enterocytozoon bieneusi is a major cause of chronic diarrhea and malabsorption in patients with AIDS. We report what we believe is the first case of intestinal infection due to E. bieneusi in a heart-lung transplant recipient who was seronegative for human immunodeficiency virus (HIV). The clinical presentation and th
Infection due to Penicillium marneffei, an emerging pathogen: review of 155 reported cases.: Clin Infect Dis. 1996 Jul;23(1):125-30. Unique Identifier : AIDSLINE MED/96412895; Duong TA; Department of Medical Microbiology and Immunology, University of; Wisconsin, Madison, USA.; A disseminated and progressive infection, penicilliosis marneffei is the third most common opportunistic infection in human immunodeficiency virus (HIV)-infected patients in certain parts of Southeast Asia. Penicillium marneffei is endemic in Southeast Asia and the southern part of Chin
Infectious complications of human T cell leukemia/lymphoma virus type I infection.: Clin Infect Dis. 1996 Jul;23(1):138-45. Unique Identifier : AIDSLINE MED/96412897; Marsh BJ; Infectious Disease Section, Dartmouth-Hitchcock Medical Center,; Lebanon, New Hampshire 03756, USA.; Infection with human T cell leukemia/lymphoma virus type I (HTLV-I) has been etiologically associated with two diseases: adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. Increasing evidence suggests that HTLV-I infection may be associated with immunosuppression and, as a consequence
Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Jul;23(1):15-27. Unique Identifier : AIDSLINE MED/96412877; Spooner KM; Lane HC; Masur H; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland 20892, USA.
Reliving a nightmare: a hard (and tragic) lesson in humility.: Clin Infect Dis. 1996 Jul;23(1):160-5. Unique Identifier : AIDSLINE MED/96412899; DiNubile MJ; Department of Medicine, Cooper Hospital/University Medical; Center, Camden, New Jersey, USA.
Remember Rocky Mountain spotted fever--a lesson in ethical principles [editorial]: Clin Infect Dis. 1996 Jul;23(1):165-6. Unique Identifier : AIDSLINE MED/96412900; Woodward TE
Increased radionuclide uptake on bone scintiscans: a common but not clinically significant finding for human immunodeficiency virus type 1-infected patients free of osteoarticular symptoms.: Clin Infect Dis. 1996 Jul;23(1):170-2. Unique Identifier : AIDSLINE MED/96412902; Rubies-Prat J; Coll J; del Rio L; Soriano JC; Marinoso ML; Serrano S; Department of Medicine, Hospital del Mar, Universidad Autonoma; de Barcelona, Spain.; The aim of this study was to describe findings of bone scintiscans and their clinical significance for patients infected with human immunodeficiency virus type 1 (HIV-1); 33 HIV-1-infected patients (22 men and 11 women) free of osteoarticular symptoms were included in the study. Plain bone roentgenograms, bone mineral
Primary tuberculosis of the larynx in a patient infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Jul;23(1):183-4. Unique Identifier : AIDSLINE MED/96412907; Nasti G; Tavio M; Rizzardini G; De Paoli P; Morassut S; Barzan L; Carbone A; Tirelli U; Centro di Riferimento Oncologico (Division of Medical Oncology; and AIDS, Microbiology-Immunology-Virology Division, Department; of Radiology, Division of Otolaryngology, and Division of; Pathology) Aviano, Italy.
Maxillary sinusitis caused by Nocardia nova.: Clin Infect Dis. 1996 Jul;23(1):184-5. Unique Identifier : AIDSLINE MED/96412908; Unzaga MJ; Crovetto MA; Santamaria JM; Rojo P; Llanos A; Ezpeleta C; Cisterna R; Department of Microbiology, Hospital de Basurto, Bilbao, Spain.
Thallium-201 single photon emission computed tomography in the management of contrast-enhancing brain lesions in a patient with AIDS.: Clin Infect Dis. 1996 Jul;23(1):185-6. Unique Identifier : AIDSLINE MED/96412909; Gianotti N; Marenzi R; Messa C; Terreni MR; Rocca A; Castagna A; Department of Infectious Diseases, San Raffaele Scientific; Institute, Milan, Italy.
The significance of isolated antibody to hepatitis B core antigen seropositivity in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Jul;23(1):189-90. Unique Identifier : AIDSLINE MED/96412912; Davaro RE; Cheeseman SH; Keroack MA; Ellison RT 3rd; Department of Medicine, University of Massachusetts Medical; Center, Worcester, USA.
Polysaccharide antigen in brain tissue of AIDS patients with cryptococcal meningitis.: Clin Infect Dis. 1996 Jul;23(1):194-5. Unique Identifier : AIDSLINE MED/96412915; Lee SC; Casadevall A; Department of Pathology (Neuropathology), Albert Einstein College; of Medicine, Bronx, New York, USA.
Pleural pseudotumoral mass revealing an extrapulmonary Pneumocystis carinii infection.: Clin Infect Dis. 1996 Jul;23(1):199-200. Unique Identifier : AIDSLINE MED/96412919; Kaplanski G; Granel B; Di Stefano D; Durand JM; Soubeyrand J; Service de Medecine Interne, Hopital Sainte-Marguerite, Institut; Paoli-Calmettes, Marseille, France.
Prednisone therapy is not associated with increased risk of herpetic infections in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Jul;23(1):201-2. Unique Identifier : AIDSLINE MED/96412921; Keiser P; Jockus J; Horton H; Smith JW; University of Texas Southwestern Medical Center, Dallas, USA.
Adjunctive immunologic therapy for Cryptococcus neoformans infections [letter]: Clin Infect Dis. 1996 Jul;23(1):209-10. Unique Identifier : AIDSLINE MED/96412927; Kitchen LW
Photo quiz. Pepto Bismol poisoning.: Clin Infect Dis. 1996 Jul;23(1):37,159. Unique Identifier : AIDSLINE MED/96412879; Hearney EG; Fuhrer J; Marioz P; Department of Infectious Diseases, SUNY at Stony Brook 11794,; USA.
Natural history of perinatal hepatitis C virus infection.: Clin Infect Dis. 1996 Jul;23(1):47-50. Unique Identifier : AIDSLINE MED/96412882; Palomba E; Manzini P; Fiammengo P; Maderni P; Saracco G; Tovo PA; Department of Pediatrics, University of Turin, Italy.; In order to outline the natural course of perinatal hepatitis C virus (HCV) infection, we prospectively followed seven HCV-positive children for a mean period of 65.1 months (range, 26-90 months). Physical examination findings, growth, and bilirubin and immunoglobulin levels were constantly normal. All children were s
Acute primary human immunodeficiency virus type 1 infection in a patient with concomitant cytomegalovirus encephalitis.: Clin Infect Dis. 1996 Jul;23(1):66-70. Unique Identifier : AIDSLINE MED/96412885; Berger DS; Bucher G; Nowak JA; Gomatos PJ; Center for Special Immunology, Chicago Illinois 60626, USA.; We report what we believe is the first case of primary human immunodeficiency virus type 1 (HIV-1) infection and simultaneous cytomegalovirus ( CMV ) encephalitis, which was confirmed by detection of CMV DNA in the patient s ce
Diagnosing and treating cytomegalovirus pneumonia in patients with AIDS.: Clin Infect Dis. 1996 Jul;23(1):76-81. Unique Identifier : AIDSLINE MED/96412887; Rodriguez-Barradas MC; Stool E; Musher DM; Gathe J Jr; Goldstein J; Genta RM; Yoffe B; Medical Services, Veterans Affairs Medical Center, Houston, Texas; 77030, USA.; Because cytomegalovirus ( CMV ) can be isolated from pulmonary secretions of human immunodeficiency virus (HIV)-infected patients without causing disease, its clinical significance as a cause of pneumonia in this patient popula
Epidemiology of cryptococcosis in France: a 9-year survey (1985-1993). French Cryptococcosis Study Group.: Clin Infect Dis. 1996 Jul;23(1):82-90. Unique Identifier : AIDSLINE MED/96412888; Dromer F; Mathoulin S; Dupont B; Laporte A; Centre National de Reference des Mycoses et des Antifongiques,; Institut Pasteur, Paris, France.; We analyzed the data collected during a nationwide survey of cryptococcosis (1985-1993). We first checked the quality of the survey. The stability of its completeness (approximately 50%) and its representativity were assessed by the capture-recapture method after we cross-checked our data on cryptococcosis (as a prese
Individual and environmental factors associated with infection due to Cryptococcus neoformans serotype D. French Cryptococcosis Study Group.: Clin Infect Dis. 1996 Jul;23(1):91-6. Unique Identifier : AIDSLINE MED/96412889; Dromer F; Mathoulin S; Dupont B; Letenneur L; Ronin O; Centre National de Reference des Mycoses et des Antifongiques,; Institut Pasteur, Paris, France.; Differences between the two varieties of Cryptococcus neoformans with regard to geographic distribution, epidemiology, and even pathogenicity have been described. None between C. neoformans variety neoformans serotypes A and D have been reported. We reviewed 452 cases of cryptococcosis diagnosed in
[Count of major lymphocyte subsets and their mitogenic response after lethal irradiation and transplantation of syngeneic bone marrow from young and old donors]: Biull Eksp Biol Med. 1996 Sep;122(9):301-4. Unique Identifier : AIDSLINE MED/97096461; Butenko GM; Kudinov IuG; Maksiuk TV; Pishel' IN; Bazyka DA; Beliaeva NV; Azarskova MV
Beliefs and attitudes towards AIDS policies and educational programs among Japanese businesses.: Occup Med (Oxf). 1996 Oct;46(5):356-60. Unique Identifier : AIDSLINE MED/97075759; Muto T; Fukuwatari Y; Onoda K; Department of Public Health, School of Medicine, Juntendo; University, Tokyo, Japan.; This study was undertaken to clarify the beliefs and attitudes of Japanese businesses towards AIDS. Questionnaires were mailed to 1,655 Japanese companies listed on the Tokyo Stock Exchange in June 1993, and the response rate was 38% (n = 620). About 60% of the responding companies had already implemented or were deve
Gender differentials in tuberculosis: the role of socio-economic and cultural factors.: Tuber Lung Dis. 1996 Oct;77(5):391-400. Unique Identifier : AIDSLINE MED/97118258; Hudelson P; London School of Hygiene and Tropical Medicine, UK.; This paper reviews current knowledge about the role that socio-economic and cultural factors play in determining gender differentials in tuberculosis (TB) and tuberculosis control. The studies reviewed suggest that socio-economic and cultural factors may be important in two ways: first, they may play a role in determi
The molecular epidemiology of tuberculosis in New York City: the importance of nosocomial transmission and laboratory error.: Tuber Lung Dis. 1996 Oct;77(5):407-13. Unique Identifier : AIDSLINE MED/97118260; Frieden TR; Woodley CL; Crawford JT; Lew D; Dooley SM; National Center for Prevention Services, Centers for Disease; Control and Prevention, Atlanta, GA, USA.; SETTING: During the 1980s, New York City experienced a rapid increase of tuberculosis cases, more than 40% of which were human immunodeficiency virus (HIV)-associated. OBJECTIVE: To better define the molecular epidemiology of tuberculosis in New York City. DESIGN: We collected an isolate from every patient in New York
Impact of short-course therapy on tuberculosis drug resistance in South-West Burkina Faso.: Tuber Lung Dis. 1996 Oct;77(5):429-36. Unique Identifier : AIDSLINE MED/97118264; Ledru S; Cauchoix B; Yameogo M; Zoubga A; Lamande-Chiron J; Portaels F; Chiron JP; Laboratoire de Microbiologie, Centre MURAZ, OCCGE, Burkina Faso.; SETTING: The Regional Tuberculosis Centre and the Muraz Centre in Bobo-Dioulasso, Burkina Faso . OBJECTIVES: To observe the trend of primary drug resistance in pulmonary tuberculosis patients 5 years into a short-course treatment programme and to assess the possible implementation
Effects of the human immunodeficiency virus on tuberculosis in children.: Tuber Lung Dis. 1996 Oct;77(5):437-43. Unique Identifier : AIDSLINE MED/97118265; Jeena PM; Mitha T; Bamber S; Wesley A; Coutsoudis A; Coovadia HM; Department of Paediatrics and Child Health, Faculty of Medicine,; University of Natal, Congella, South Africa.; Pillays@Med.und.ac.za; SETTING: Human immunodeficiency virus (HIV) infection has altered the epidemiological and clinical profile of tuberculosis (TB) worldwide. In children however, unlike in adults, very little has been documented about the interaction between the two diseases. OBJECTIVE: To examine the clinical features and response to T
No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis.: Tuber Lung Dis. 1996 Oct;77(5):444-8. Unique Identifier : AIDSLINE MED/97118266; Hawken MP; Ojoo JC; Morris JS; Kariuki EW; Githui WA; Juma ES; Gathua SN; Kimari JN; Thiong'o LN; Raynes JG; Broadbent P; Gilks CF; Otieno LS; McAdam KP; Clinical Research Centre, Kenya Medical Research Institute,; Nairobi, Kenya.; SETTING: Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya. OBJECTIVE: To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis. DESIGN: One hundred and seventy-four patients with proven tuberculosis (90 HIV-1
The effect of in vitro human immunodeficiency virus infection on dendritic-cell differentiation and function.: Blood. 1996 Dec 1;88(11):4215-28. Unique Identifier : AIDSLINE MED/97099280; Canque B; Rosenzwajg M; Camus S; Yagello M; Bonnet ML; Guigon M; Gluckman JC; Laboratoire de Biologie et Pathologie des Deficits Immunitaires,; l'Ecole Pratique des Hautes Etudes, Faculte de Medecine, Paris,; France.; CD1a+ dendritic cells (DC) differentiate from a major population of nonadherent CD13(hi)lin- cells that appear when human cord blood CD34+ hematopoietic progenitor cells are cultured with stem-cell factor, granulocyte/macrophage (MA) colony-stimulating factor, and tumor necrosis factor-alpha (TNF-alpha) for 5 days. CD
Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic gamma delta T-cell origin.: Blood. 1996 Dec 1;88(11):4265-74. Unique Identifier : AIDSLINE MED/97099286; Cooke CB; Krenacs L; Stetler-Stevenson M; Greiner TC; Raffeld M; Kingma DW; Abruzzo L; Frantz C; Kaviani M; Jaffe ES; Hematopathology Section, National Cancer Institute, National; Institutes of Health, Bethesda, MD 20892-1500, USA.; We identified eight cases of T-cell lymphoma with evidence of a gamma delta phenotype over a 13-year period. Seven of these cases conformed to a distinct clinicopathologic entity of hepatosplenic gamma delta T-cell lymphoma. Nearly all of these patients were young adult males (five of seven), with a median age at pres
Apoptotic antigens, B2-glycoprotein I, and antiphospholipid autoantibodies [letter]: Blood. 1996 Dec 1;88(11):4396. Unique Identifier : AIDSLINE MED/97099301; Cheng HM
Inhibition of HIV-1 infectivity by low molecular weight heparin. Results of in vitro studies and a pilot clinical trial in patients with advanced AIDS.: Int J Clin Lab Res. 1996;26(2):124-31. Unique Identifier : AIDSLINE MED/97009261; Howell AL; Taylor TH; Miller JD; Groveman DS; Eccles EH; Zacharski LR; Veterans Administration Medical Center, White River Junction, VT; 05009, USA.; Several sulfated polysaccharides have been shown to have anti-HIV activity in vitro. However, many of these compounds are not suited for use in vivo because they present an increased risk of bleeding or cannot be administered chronically. We tested the anti-HIV effects of low molecular weight heparin (LMW-heparin) (En
Development of Th 1- or Th 2-dominated immune responses: what about the polarizing signals?: Int J Clin Lab Res. 1996;26(2):83-98. Unique Identifier : AIDSLINE MED/97009256; Romagnani S; Istituto di Medicina Interna e Immunoallergologia, Universita di; Firenze, Florence, Italy.; Type 1 helper T cells and type 2 helper T cells represent two extremely polarized forms of the effector specific immune response, based on a distinctive profile of cytokine production. Type 1- and type 2 helper T cell-dominated immune responses play a different role in both protection and immunopathology. The differen
T-cell gene therapy.: Curr Opin Biotechnol. 1996 Dec;7(6):629-34. Unique Identifier : AIDSLINE MED/97094563; Hege KM; Roberts MR; Cell Genesys Inc, 322 Lakeside Drive, Foster City, CA 94404, USA.; hege_kristen@cellgenesys.com; In the past year, a number of human gene therapy trials involving the adoptive transfer of genetically modified T lymphocytes have been reported. These include trials of adenosine deaminase gene transfer in children with severe combined immunodeficiency syndrome, a gene-marking study of Epstein-Barr virus-specific cyt
The new generation of recombinant viral subunit vaccines.: Curr Opin Biotechnol. 1996 Dec;7(6):646-52. Unique Identifier : AIDSLINE MED/97094566; Ellis RW; Astra Research Center Boston, 128 Sidney Street, Cambridge, MA; 02139, USA.; There have been two major focal points for the development of recombinant viral subunit vaccines. Expression strategies for the candidate antigens have focused increasingly on producing more natural antigenic structures, for example, virus-like particles. Also, new adjuvants have been used in order to increase immunog
Men with learning disabilities who have sex with men in public places: mapping the needs of services and users in south east London.: J Intellect Disabil Res. 1996 Jun;40 ( Pt 3):241-51. Unique Identifier : AIDSLINE MED/96405525; Cambridge P; Tizard Centre, University of Kent at Canterbury, England.; This survey investigated the prevalence of men with learning disabilities who have sex with men in public places in three south east London boroughs. The work was administered through contact with providers of services for people with learning disabilities and was commissioned by the local health authority. It represe
Idiopathic esophageal ulceration in patients infected with human immunodeficiency virus.: J Assoc Acad Minor Phys. 1996;7(4):93-8. Unique Identifier : AIDSLINE MED/97091200; Vega KJ; Bollu J; Dajani EZ; Trotman BW; Gastroenterology Division/Department of Medicine, LMDNJ-New; Jersey, Medical School 07103, USA.; Esophageal disease is a common and important cause of morbidity and mortality in patients with human immunodeficiency virus (HIV) infection. The etiology of HIV-related esophageal ulceration varies. After all known etiologies are excluded, a subgroup of patients remains with esophageal ulceration known as idiopathic e
Early bronchoscopic diagnosis of concomitant tuberculosis and Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection.: J Assoc Acad Minor Phys. 1996;7(4):99-103. Unique Identifier : AIDSLINE MED/97091201; Albino JA; Shapiro JM; National Tuberculosis Center, LMDNJ-New Jersey Medical School,; Newark, 07103, USA.; Pulmonary infections, including mixed infections, are common in patients with human immunodeficiency virus (HIV), and a specific diagnosis is desirable to direct therapy. In a retrospective study of patients suspected of having Pneumocystis carinii pneumonia, we examined the usefulness of fiberoptic bronchoscopy in th
Cross-linking the TCR complex induces apoptosis in CD4+8+ thymocytes in the presence of cyclosporin A.: Dev Immunol. 1996;5(1):1-15. Unique Identifier : AIDSLINE MED/96425665; Poetschke HL; Klug DB; Walker D; Richie ER; University of Texas, M.D. Anderson Cancer Center, Smithville; 78957, USA.; Although it is generally agreed that TCR ligation is a minimal requirement for negative selection in the CD4+8+ double-positive (DP) thymocyte subset, the costimulatory requirements and specific signaling events necessary to induce apoptosis are not well defined. We have explored the consequences of cross-linking CD3/
Advances in HIV markers [news]: Can Fam Physician. 1996 Nov;42:2301-2. Unique Identifier : AIDSLINE MED/97093863; Elliott EB
The time has come. One world, one hope [news]: Can Fam Physician. 1996 Nov;42:2302-3. Unique Identifier : AIDSLINE MED/97093864; Elliott EB
Psychiatric morbidity among dermatology inpatients.: Natl Med J India. 1996 Sep-Oct;9(5):208-10. Unique Identifier : AIDSLINE MED/97091339; Pulimood S; Rajagopalan B; Rajagopalan M; Jacob M; John JK; Department of Christian Medical College Hospital, Vellore, Tamil; Nadu, India.; BACKGROUND: Research on psychiatric morbidity among patients with dermatological diseases generally focuses on outpatients and questionnaire-based surveys. The aim of this study was to determine the prevalence and nature of psychiatric morbidity among dermatological inpatients with diagnosis being made by psychiatric
A new method for the detection and quantitative measurement of the contents of trichosanthes root component composing Chinese traditional medicines.: Biol Pharm Bull. 1996 Jun;19(6):783-90. Unique Identifier : AIDSLINE MED/96392685; Kitagawa T; Bai G; Fujiwara K; Akahori A; Sonoi S; Kondo S; Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.; A new method was developed to estimate the content of Trichosanthes root (TR) component in two Chinese traditional medicines. Characteristic antigens of TR were separated from TR extract using rabbit antiserum specific for TR, a dried root tuber of Trichosanthes kirilowii. Two selected antibody enzyme immunoassay (SAE
Health-related quality of life of HIV-infected women: evidence for the reliability, validity and responsiveness of the Medical Outcomes Study Short-Form 20.: Qual Life Res. 1996 Feb;5(1):47-55. Unique Identifier : AIDSLINE MED/97057027; Smith MY; Feldman J; Kelly P; DeHovitz JA; Chirgwin K; Minkoff H; Memorial Sloan-Kettering Cancer Centre, New York, New York,; 10021, USA.; The purpose of this study was to assess the reliability, validity and responsiveness of a health-related quality of life (HRQOL) instrument, the Medical Outcomes Short-Form 20-Item General Health Survey (MOS SF-20), in a sample of women with the human immunodeficiency virus (HIV). Longitudinal data were collected on 2
Identification of Microsporidia causing human disease.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):104S-105S. Unique Identifier : AIDSLINE GENBANK; Hollister WS; Canning EU; Anderson CL; Department of Biology, Imperial College, London, England.
Identification of a new Nosema-like microsporidian associated with myositis in an AIDS patient.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):108S. Unique Identifier : AIDSLINE MED/96420194; Cali A; Takvorian PM; Lewin S; Rendel M; Sian C; Wittner M; Weiss LM; Dept. of Biological Sciences, Rutgers University Newark, NJ; 07102, USA.
Comparative rDNA analysis of Microsporidia including AIDS related species.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):110S. Unique Identifier : AIDSLINE MED/96420196; Vossbrinck CR; Baker MD; Didier ES; Conn. Ag. Expt. Sta., New Haven 06504, USA.
Detection of T.gondii-DNA by PCR in AIDS-related toxoplasmic encephalitis.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):118S-119S. Unique Identifier : AIDSLINE MED/96420201; Cingolani A; De Luca A; Ammassari A; Murri R; Linzalone A; Grillo R; Giancola ML; Antinori A; Department of Infectious Diseases, Catholic University, Rome,; Italy.
Cyclospora sp:life cycle studies in patient by electron-microscopy.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):128S-129S. Unique Identifier : AIDSLINE MED/96420207; Deluol AM; Teilhac MF; Poirot JL; Heyer F; Beaugerie L; Chatelet FP; Parasitology Laboratory, Hopital Rothschild, Paris, France.
Cutaneous lesions due to Acanthamoeba sp in a patient with AIDS.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):130S-131S. Unique Identifier : AIDSLINE MED/96420208; Deluol AM; Teilhac MF; Poirot JL; Maslo C; Luboinski J; Rozenbaum W; Chatelet FP; 1 Parasitology Laboratory, Hopital Rothschild, Paris, France.
Detection of Pneumocystis carinii DNA in HIV patients with P. carinii pneumonia (PCP) and in animal models.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):18S-19S. Unique Identifier : AIDSLINE MED/96420125; Tamburrini E; Mencarini P; Visconti E; Zolfo M; De Luca A; Siracusano A; Ortona E; Margutti P; Wakefield AE; Peters SE; Denis CM; Dei-Cas E; Dept. of Infectious Diseases, Univ. Cattolica S. Cuore, Rome,; Italy.
Comparison of two PCR methods for detection of Pneumocystis carinii in bronchoalveolar lavage fluid.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):20S. Unique Identifier : AIDSLINE MED/96420126; Tamburrini E; Mencarini P; Visconti E; Zolfo M; De Luca A; Siracusano A; Ortona E; Margutti P; Wakefield AE; Dept. of Infectious Diseases, Univ. Cattolica S. Cuore, Rome,; Italy.
Pneumocystis carinii detection in 158 HIV-seronegative patients.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):28S. Unique Identifier : AIDSLINE MED/96420133; Mazars E; Herbecq S; Szypura AS; Fruit J; Camus D; Dei-Cas E; U42 INSERM, 59651 Villeneuve d'Ascq, France.
Development of a molecular typing method for Pneumocystis carinii sp.f. hominis.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):34S. Unique Identifier : AIDSLINE MED/96420138; Hauser PM; Blanc DS; Bille J; Telenti A; Francioli P; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Prevalence of various Pneumocystis carinii sp. f. hominis types in different geographical locations.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):37S. Unique Identifier : AIDSLINE MED/96420141; Lee CH; Lu JJ; Tang X; Jiang B; Li B; Jin S; Bartlett MS; Lundgren B; Atzori C; Orlando G; Cargnel A; Smith JW; Dept. of Path. and Lab. Med., Indiana Univ. School of Medicine,; Indianapolis, USA.
Diagnosis of PCP by ITSs nested PCR on notinvasive oropharingeal samples.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):41S. Unique Identifier : AIDSLINE MED/96420145; Atzori C; Agostoni F; Gubertini G; Cargnel A; II Div.Inf.Dis., L.Sacco Hospital, Milan, Italy.; Pneumocystis carinii pneumonia is an opportunistic disease usually affecting immunocompromised hosts. Diagnosis is based on the microscopical detection of microrganism on BAL, an invasive sample which requires pt compliance for collection and skilled health care personnel for examination. In order to verify the possib
P.carinii DNA detected by ITSs nested PCR in serum and PBMC of AIDS patients with PCP.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):42S. Unique Identifier : AIDSLINE MED/96420146; Atzori C; Agostoni F; Angeli E; Orlando G; Cargnel A; II Div. Infectious Diseases, Luigi Sacco Hospital, Milan, Italy.; Pneumocystis carinii pneumonia (PCP) is usually diagnosed by examination of BAL, a sample often unpleasant to be collected from immunocompromised host affected by acute respiratory disease. We studied by the Internal Transcribed Spacers (ITSs) nested PCR the presence of P.carinii DNA in serum and Peripheral Blood Mono
ITSs typing of P.carinii samples from Italy, The Netherlands and Tanzania.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):43S. Unique Identifier : AIDSLINE MED/96420147; Atzori C; Agostoni F; Cargnel A; Perenboom R; Beckers P; II Div. Inf. Dis., L.Sacco Hosp. Milan, Italy.; P.carinii molecular epidemiology appears a new interesting investigational field to understand distribution and incidence of isolates from different geographical locations. Recently a typing system, the Type Specific Oligoblotting (TSO) based on 6 different sequences of the Internal Transcribed Spacers (ITSs) of P.car
Pneumocystis carinii pneumonia in four mammal species: histopathology and ultrastructure.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):47S-48S. Unique Identifier : AIDSLINE MED/96420151; Creusy C; Bahon-le Capon J; Fleurisse L; Mullet C; Dridba M; Cailliez JC; Antoine M; Camus D; Dei-Cas E; Faculte Libre Medecine, Univ. Catholique, Lille, France.
Multi-locus genotype switching in Pneumocystis carinii sp. f. hominis: evidence for reinfection.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):50S. Unique Identifier : AIDSLINE MED/96420153; Keely SP; Stringer JR; Dept. Mol. Genet. Biochem. & Microbiol., Univ. of Cincinnati,; Ohio 45267, USA.
Biodiversity of French and Italian human Pneumocystis carinii.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):54S-55S. Unique Identifier : AIDSLINE MED/96420157; Latouche S; Ortona E; Mazars E; Margutti P; Siracusano A; Tamburrini E; Guyot K; Nigou M; Roux P; Lab. of Parasitol-Myco, CHU Saint-Antoine, Paris.
Usefulness of molecular biology for Pneumocystis carinii hominis pneumonia epidemiology.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):56S-57S. Unique Identifier : AIDSLINE MED/96420158; Latouche S; Poirot JL; Lavrard I; Miltgen M; Nigou M; Roux P; Lab. of Parasitol-Myco, CHU Saint-Antoine, Paris.
Pneumocystis carinii pneumonia: evolution from 1981 to 1995 in two Paris hospitals.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):58S-59S. Unique Identifier : AIDSLINE MED/96420159; Poirot JL; Marteau M; Lavrard I; Meyohas MC; Cadranel J; Roux P; Dept. of Parasitol, Saint-Antoine Hospital Paris.
Broncho-pulmonary cryptosporidiosis in four HIV-infected patients.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):78S-79S. Unique Identifier : AIDSLINE MED/96420173; Poirot JL; Deluol AM; Antoine M; Heyer F; Cadranel J; Meynard JL; Meyohas MC; Girard PM; Roux P; Dept. of Parasitol, Saint-Antoine hospital.
Evaluation of PCR technique for diagnosing Pneumocystis carinii pneumonia in HIV positive patients using oropharyngeal washings.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):9S. Unique Identifier : AIDSLINE MED/96420118; Lundgren B; Benfield T; Lundgren JD; Dept. of Clin. Microbiol, Hvidovre Hospital, Copenhagen, Denmark.
Molecular epidemiology of Encephalitozoon cuniculi and first detection of Enterocytozoon bieneusi in faecal samples of pigs.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):93S. Unique Identifier : AIDSLINE GENBANK/U61180; Deplazes P; Mathis A; Muller C; Weber R; Institute of Parasitology, Univ. of Zurich, Switzerland.
Retesting of sera for antibodies to HIV-1/HIV-2.: Commun Dis Rep CDR Wkly. 1996 May 3;6(18):153. Unique Identifier : AIDSLINE MED/97089510
HIV infection and AIDS in the United States.: Commun Dis Rep CDR Wkly. 1996 May 3;6(18):153, 156. Unique Identifier : AIDSLINE MED/97089511
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1996 Oct 18;6(42):371-4. Unique Identifier : AIDSLINE MED/97091053
Romanian adoption. The Manitoba experience.: Arch Pediatr Adolesc Med. 1996 Dec;150(12):1278-82. Unique Identifier : AIDSLINE MED/97112311; Benoit TC; Jocelyn LJ; Moddemann DM; Embree JE; Department of Pediatrics and Child Health, Children's Hospital,; Health Sciences Centre, Winnipeg, Manitoba.; OBJECTIVE: To study the developmental, behavioral, and medical features in a cohort of Romanian children adopted by Manitoba families. DESIGN: A prospective longitudinal study. SETTING: The Child Development Clinic, Children s Hospital, Winnipeg, Manitoba, from September 1990 to June 1992. PATIENTS: Developmental, beh
Evolving ethical issues in selection of subjects for clinical research.: Camb Q Healthc Ethics. 1996 Summer;5(3):334-45. Unique Identifier : AIDSLINE MED/97016184; Weijer C; Clinical Trials Research Group, McGill University, Montreal,; Canada.
For her own good: protecting (and neglecting) women in research.: Camb Q Healthc Ethics. 1996 Summer;5(3):346-61. Unique Identifier : AIDSLINE MED/97016185; Shuster E; Department of Psychiatry, University of Pennsylvania,; Philadelphia, USA.
Patient access to experimental drugs and AIDS clinical trial designs: ethical issues.: Camb Q Healthc Ethics. 1996 Summer;5(3):400-9. Unique Identifier : AIDSLINE MED/97016189; Schuklenk U; Hogan C; Monash University Centre for Human Bioethics, Australia.
HIV-related parotid lymphoepithelial cysts. Immunohistochemistry and 3-D reconstruction of surgical and autopsy material with special reference to formal pathogenesis.: Virchows Arch. 1996 Oct;429(2-3):139-47. Unique Identifier : AIDSLINE MED/97075324; Ihrler S; Zietz C; Riederer A; Diebold J; Lohrs U; Institute of Pathology, Ludwig Maximilians University, Munchen,; Germany.; Whether lymphoepithelial cysts in the parotid glands in HIV-infected patients develop from pre-existing salivary gland inclusions in intraparotid lymph nodes or from a lymphoepithelial lesion of salivary parenchyma is unclear. To examine their pathogenesis we performed a histological and immunohistochemical study of s
Chronic rejection of concordant aortic xenografts in the hamster-to-rat model.: Transpl Immunol. 1996 Sep;4(3):192-7. Unique Identifier : AIDSLINE MED/97048617; Scheringa M; Buchner B; de Bruin RW; Geerling RA; Melief MJ; Mulder AH; Schraa EO; Ijzermans JN; Marquet RL; Department of Surgery, Leiden University Hospital, The; Netherlands.; Several groups have demonstrated that it is possible to obtain long-term graft survival of concordant xenografts. One of the important questions that remains is whether xenografts are susceptible to chronic rejection. To answer this question we used the aorta transplantation model. One centimetre of hamster aorta was
Xenogeneic iso-skin graft and mixed lymphocyte reaction studies using HLA-DP transgenic mice.: Transpl Immunol. 1996 Sep;4(3):220-6. Unique Identifier : AIDSLINE MED/97048622; Hagihara M; Shimura T; Takebe K; Munkhbat B; Sato T; Tsuchida F; Sato K; Tsuji K; Department of Transplantation Immunology, Tokai University School; of Medicine, Kanagawa, Japan.; To elucidate the cellular responses against xeno-MHC antigens, in vitro mixed lymphocyte culture (MLC) and in vivo skin grafting (SG) studies were conducted using HLA-DP transgenic mice (B6-DP mice). Xenogenic iso-(B6-DP to B6 mice) MLC showed positive but much lower responses compared to allo-MLC responses. Neverthel
[Expanded serologic infection testing of autologous blood donors: a report of experiences]: Beitr Infusionsther Transfusionsmed. 1996;33:196-200. Unique Identifier : AIDSLINE MED/97019457; Zimmermann R; Weisbach V; Wittmann G; Zingsem J; Neidhardt B; Eckstein R; Abteilung fur Transfusionsmedizin und Hamostaseologie,; Friedrich-Alexander-Universitat Erlangen-Nurnberg, Deutschland.; PURPOSE: The transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV-1/2) may cause serious disease in the recipient in cases of inadvertant homologous transfusion of autologous blood. Therefore data on the incidence of these infections in autologous blood donors are nece
[Nanofiltration in production of Beriplex P/N: increasing the capacity of virus elimination while maintaining product quality]: Beitr Infusionsther Transfusionsmed. 1996;33:220-4. Unique Identifier : AIDSLINE MED/97019462; Romisch J; Groner A; Bernhardt D; Diehl KH; Hein B; List W; Muller HG; Nowak T; Ronneberger H; Schuler E; Weimer T; Hilfenhaus J; Centeon Pharma GmbH, Marburg/Lahn, Deutschland.; For the manufacture of the PCC Beriplex P/N, nanofiltration was introduced into the production process of Beriplex HS providing an additional means to heat treatment for the clearance/inactivation of viruses. By nanofiltration, large enveloped viruses (HSV-1, HIV-1) were completely eliminated by a factor of more than
[Donor exclusions, discarded blood and transfusion unsuited blood conserves of 2,13 million potential blood donors 1991 to 1994]: Beitr Infusionsther Transfusionsmed. 1996;33:81-92. Unique Identifier : AIDSLINE MED/97019436; Diekamp U; Wehrend W; Marklof E; Kamutzky K; DRK-Blutspendedienst NSOB, Springe, Deutschland.; German authorities plan to legislate transfusion safety. We report on the efficacy of donor selection, unit pre-release testing, quality assurance and look-back efforts (LBE): Among 2,127,102 visits by 503,971 donors are 8.7% first-time donors. 96% of repeaters present our donor ID-card. We defer 5.6% repeat and 18.2%
High frequencies of human T-lymphotropic virus type I (HTLV-I) infection and presence of HTLV-II proviral DNA in blood donors with anti-thyroid antibodies.: J Mol Med. 1996 Aug;74(8):471-7. Unique Identifier : AIDSLINE MED/97026683; Mine H; Kawai H; Yokoi K; Akaike M; Saito S; First Department of Internal Medicine, School of Medicine,; University of Tokushima, Japan.; To investigate the relationship between human T-lymphotropic virus (HTLV) types I and II and the pathogenesis of autoimmune thyroid diseases, we examined serum anti-thyroid antibodies in 1019 blood donors with or without serum anti-HTLV-I antibody as well as proviral DNA for HTLV-II in leukocyte DNA by the polymerase
Interesting resources from the Web.: NP News. 1996 Jul-Aug;4(4):2, 5. Unique Identifier : AIDSLINE MED/97086737; Smithing RT; Wiley MD
Rhegmatogenous retinal detachments in HIV-positive patients with ocular syphilis.: Ophthalmic Surg Lasers. 1996 Aug;27(8):699-705. Unique Identifier : AIDSLINE MED/97011626; Williams JK; Kirsch LS; Russack V; Freeman WR; Department of Ophthalmology, University of California at San; Diego, La Jolla 92093-0946, USA.; The purpose of this study is to report retinal manifestations of lues in human immunodeficiency virus (HIV)-positive patients and to suggest a method for treatment of rhegmatogenous retinal detachments in these patients. Two HIV-positive patients with bilateral retinitis were examined and treated at the authors insti
TH2 cells in allergic inflammation: a target of immunotherapy.: Clin Exp Allergy. 1996 Jul;26(7):756-65. Unique Identifier : AIDSLINE MED/96440237; Lord CJ; Lamb JR; Department of Biology, Imperial College of Science, Technology; and Medicine, London, UK.
Experimental graft versus host disease in the (BN x LEW) F1 rat hybrid: an immunohistochemical study of early disease in oral mucosa.: Oral Dis. 1996 Mar;2(1):2-10. Unique Identifier : AIDSLINE MED/97116847; Peszkowski MJ; Fujiwara K; Warfvinge G; Larsson A; Department of Oral Pathology, Lund University, Malmo, Sweden.; OBJECTIVE: To study the initial cellular events in oral mucosa (tongue) of experimental hyperplastic GVHD, in order to increase our understanding of the possible pathogenic mechanisms that may be shared with eg mercury (and other drug)-induced immunological reactions. MATERIALS AND METHODS: GVHD was induced by one i.v
Knowledge of and attitudes about blood-borne viruses and infection control in Brazilian dental practice.: Oral Dis. 1996 Mar;2(1):41-4. Unique Identifier : AIDSLINE MED/97116851; Jorge J; Jorge R; Almeida OP; Scully C; Department of Oral Pathology, Faculty of Odontology, Piracicaba; SP, Brazil.; OBJECTIVE: To determine whether there were any recent changes in hepatitis B immunisation of dental staff, infection control or understanding of viral infections in Brazilian dentists. DESIGN: A randomised survey was conducted on 740 dentists attending the National Dental Congress in Sao Paulo, Brazil in 1994. SUBJECT
The periodontal health of homosexual men with HIV infection: a controlled study.: Oral Dis. 1996 Mar;2(1):45-52. Unique Identifier : AIDSLINE MED/97116852; Robinson PG; Sheiham A; Challacombe SJ; Zakrzewska JM; Department of Epidemiology and Public Health, University College,; London, UK.; OBJECTIVE: Identify types, prevalence and severity of periodontal changes associated with HIV infection. DESIGN: Cross-sectional controlled blinded study. SETTING: Open access genito-urinary medicine clinic. PARTICIPANTS: Convenience sample of 794 homosexual men aged 18-65. OUTCOME MEASURES: Prevalence, extent and sev
Cellular immunity and hypersensitivity as components of periodontal destruction.: Oral Dis. 1996 Mar;2(1):96-101. Unique Identifier : AIDSLINE MED/97116858; Seymour GJ; Gemmell E; Kjeldsen M; Yamazaki K; Nakajima T; Hara K; Department of Dentistry, University of Queensland, Brisbane,; Australia.; BACKGROUND: Cellular immunity has been implicated in periodontal destruction for over 25 years. Studies in the 1970s used lymphocyte transformation and lymphokine assays to establish a role for cell-mediated mechanisms in periodontal disease. Immunohistological studies subsequently showed that the formation of gingivi
Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease.: Mol Med. 1996 Jan;2(1):27-37. Unique Identifier : AIDSLINE MED/97056192; Lane TE; Buchmeier MJ; Watry DD; Fox HS; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA.; BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can lead to severe impairments in cognition, behavior, and motor skills. The mechanism(s) by which HIV-1 induces CNS disease are not well understood. Recent evidence suggests that expression of inducible nitric oxide
Role of IgE immune complexes in the regulation of HIV-1 replication and increased cell death of infected U1 monocytes: involvement of CD23/Fc epsilon RII-mediated nitric oxide and cyclic AMP pathways.: Mol Med. 1996 Jan;2(1):38-49. Unique Identifier : AIDSLINE MED/97056193; Ouaaz F; Ruscetti FW; Dugas B; Mikovits J; Agut H; Debre P; Mossalayi MD; Molecular Immuno-hematology Group, CNRS URA625,; Pitie-Salpetriere Hospital, Paris, France.; BACKGROUND: IgE/anti-IgE immune complexes (IgE-IC) induce the release of multiple mediators from monocytes/macrophages and the monocytic cell line U937 following the ligation of the low-affinity Fc epsilon receptors (Fc epsilon RII/CD23). These effects are mediated through an accumulation of cAMP and the generation of
Neurovirulent simian immunodeficiency virus infection induces neuronal, endothelial, and glial apoptosis.: Mol Med. 1996 Jul;2(4):417-28. Unique Identifier : AIDSLINE MED/96425269; Adamson DC; Dawson TM; Zink MC; Clements JE; Dawson VL; Department of Neuroscience, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21287, USA.; BACKGROUND: Studies of human immunodeficiency virus type 1 (HIV-1) associated dementia have shown neuronal loss in discrete areas. The presence and mechanism of neuronal death, however, has remained quite elusive. One mechanism of cell death, apoptosis, has been clearly demonstrate
Overexpression of select T cell receptor V beta gene families within CD4+ and CD8+ T cell subsets of myasthenia gravis patients: a role for superantigen(s)?: Mol Med. 1996 Jul;2(4):452-9. Unique Identifier : AIDSLINE MED/96425272; Gigliotti D; Lefvert AK; Jeddi-Tehrani M; Esin S; Hodara V; Pirskanen R; Wigzell H; Andersson R; Microbiology and Tumorbiology Center (MTC), Karolinska Institute,; Stockholm, Sweden.; BACKGROUND: The principal symptoms of myasthenia gravis (MG), muscle weakness and fatigue due to impaired neuromuscular transmission, are caused by autoantibodies to the muscle nicotinic acetylcholine receptor (AChR). The mechanisms underlying the autoimmune response, however, appear to be initiated by activation of s
A critical role of nitric oxide in human immunodeficiency virus type 1-induced hyperresponsiveness of cultured monocytes.: Mol Med. 1996 Jul;2(4):460-8. Unique Identifier : AIDSLINE MED/96425273; Bukrinsky M; Schmidtmayerova H; Zybarth G; Dubrovsky L; Sherry B; Enikolopov G; Picower Institute for Medical Research, Manhasset, New York.; BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infection leads to a general exhaustion of the immune system. Prior to this widespread decline of immune functions, however, there is an evident hyperactivation of the monocyte/macrophage arm. Increased levels of cytokines and other biologically active molecules
[Apoptosis in the nervous system]: Rev Neurol. 1996 Nov;24(135):1356-60. Unique Identifier : AIDSLINE MED/97090712; Macaya A; Seccion de Neurologia Infantil, Centro de Investigaciones en; Bioquimica y Biologia Molecular, Vall d'Hebron Hospitals,; Barcelona.; Apoptosis (programmed cell death) is a distinct form of controlled cell degeneration, different from necrosis. It serves multiple physiological functions, such as the control of cell numbers during development, the maintenance of tissue homeostasis and the deletion of abnormal cells. Apoptosis has unique morphological
[Changes in the immunocompetent cell system of the peripheral blood in HIV carriage]: Lik Sprava. 1995 Mar-Apr;(3-4):112-5. Unique Identifier : AIDSLINE MED/96417148; Karabanov VR; Markov IS; Marchenko NE; HIV-carriage is characterized by hematological signs such as normocytosis of the general leucocyte count and deviations within normal range of values for myeloid series cells (neutrophiles, eosinophiles, basophiles). A peculiar hematological sign seen in HIV-infection is a finding of a raised content of cellular eleme
[A case of Kaposi's sarcoma of the eye in an AIDS patient]: Lik Sprava. 1995 Mar-Apr;(3-4):172-4. Unique Identifier : AIDSLINE MED/96417168; Barshtein IuA; Vovk AD; Antoniak SM; Shcherbyns'ka AM
Infectious disease challenges in the 1990's.: Med Health R I. 1996 Mar;79(3):100-9. Unique Identifier : AIDSLINE MED/97056951; Opal SM; Infectious Disease Fellowship Program, Brown University School of; Medicine, USA.
Physicians should support needle exchange in Rhode Island [editorial]: Med Health R I. 1996 Jun;79(6):206. Unique Identifier : AIDSLINE MED/96390291; Lewis DC; Rich JD; Brown University Center for Alcohol and Addiction Studies, USA.
AIDS and minorities.: Med Health R I. 1996 Jul;79(7):264-5. Unique Identifier : AIDSLINE MED/96390306; Fisher AE; Emgushov RT; Brown University School of Medicine, Providence, RI, USA.
Antisense oligonucleotides inhibit in vitro cDNA synthesis by HIV-1 reverse transcriptase.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):103-9. Unique Identifier : AIDSLINE MED/97000182; Boiziau C; Tarrago-Litvak L; Sinha ND; Moreau S; Litvak S; Toulme JJ; INSERM U386, Universite Bordeaux II, France.; The inhibition of reverse transcription by various chemically modified antisense oligonucleotides was studied in a cell-free system, composed of an RNA template, a primer oligodeoxynucleotide, and the HIV-1 reverse transcriptase (RT). Different mechanisms of inhibition were observed depending on the chemical structure
Correlation of activity with stability of chemically modified ribozymes in nuclei suspension.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):111-8. Unique Identifier : AIDSLINE MED/97000183; Heidenreich O; Xu X; Swiderski P; Rossi JJ; Nerenberg M; Scripps Research Institute, Department of Molecular and; Experimental Medicine, La Jolla, CA 92037, USA.; To examine hammerhead ribozyme activity in the nuclear environment, we have used nuclei isolated from HTLV-I tax transformed fibroblasts to evaluate ribozymes targeted against HTLV-I tax RNA. The ribozyme activity in nuclei suspension was strongly dependent on the resistance of the particular ribozyme to endogenous nu
A hammerhead ribozyme cleaves its target RNA during RNA preparation.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):141-4. Unique Identifier : AIDSLINE MED/97000187; Heidenreich O; Xu X; Nerenberg M; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, CA 92037, USA.; A chemically modified hammerhead ribozyme was designed to cleave the tax RNA of human T cell leukemia virus type I. This ribozyme was exogenously delivered to tax-transformed fibroblasts by DOTAP-mediated transfection. The analysis of RNA from ribozyme-transfected cells by RNase protection detected ribozyme cleavage p
4-(Arylamino)phenyl alpha-D-glucopyranosides as potential anti-HIV agents.: Carbohydr Res. 1996 Mar 18;282(2):293-8. Unique Identifier : AIDSLINE MED/97056753; Briggs JC; Haines AH; School of Chemical Sciences, University of East Anglia, Norwich,; United Kingdom.
Structure of the O-deacetylated glucuronoxylomannan from Cryptococcus neoformans Cap70 as determined by 2D NMR spectroscopy.: Carbohydr Res. 1996 Mar 22;283:95-110. Unique Identifier : AIDSLINE MED/97056926; Bacon BE; Cherniak R; Kwon-Chung KJ; Jacobson ES; Department of Chemistry, Georgia State University, Atlanta 30303,; USA.; Cryptococcus neoformans, an opportunistic pathogen, is the fourth leading cause of death among AIDS patients. The yeast s capsule is a major virulence factor, and serotype is related to the chemical structure of glucuronoxylomannan (GXM), its capsular polysaccharide. The GXM from Cap70, a hypocapsular mutant of seroty
Immune response against medullary thyroid carcinoma (MTC) induced by parental and/or interleukin-2-secreting MTC cells in a rat model of human familial medullary thyroid carcinoma.: Cancer Immunol Immunother. 1996 Oct;43(2):116-23. Unique Identifier : AIDSLINE MED/97112466; Lausson S; Fournes B; Borrel C; Milhaud G; Treilhou-Lahille F; Laboratoire d'Endocrinologie Cellulaire et Evolution, U. R. A.; 1116 CNRS, Universite Paris-Sud, Centre d'Orsay, France.; The existence of inherited aggressive forms of medullary thyroid carcinoma (MTC), and their resistance to all classical therapies, make it a prime candidate for adoptive immunotherapy. As a prelude to a vaccine for the protection of family members at risk of developing the disease, we investigated the immunological an
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.: Cell. 1996 Nov 15;87(4):745-56. Unique Identifier : AIDSLINE MED/97083584; Endres MJ; Clapham PR; Marsh M; Ahuja M; Turner JD; McKnight A; Thomas JF; Stoebenau-Haggarty B; Choe S; Vance PJ; Wells TN; Power CA; Sutterwala SS; Doms RW; Landau NR; Hoxie JA; Hematology-Oncology Division, University of Pennsylvania,; Philadelphia 19104, USA.; Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these molecules serve as CD4-associated cofactors is unclear. In the present report, we show that one member of this family, termed Fusin/ CXCR4, is
The use of SCID mice in biotechnology and as a model for human disease.: Crit Rev Biotechnol. 1996;16(1):95-118. Unique Identifier : AIDSLINE MED/97090002; Sandhu JS; Boynton E; Gorczynski R; Hozumi N; Department of Surgery, University of Toronto, Ontario, Canada.; The use of SCID (severe combined immunodeficient) mice in medical research and biotechnology has increased tremendously in recent years. This review outlines the major characteristics of these animals and the impediments that they pose to the engraftment of human cells and tissues. The development of our SCID mice pre
New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors.: Chem Pharm Bull (Tokyo). 1996 Aug;44(8):1436-9. Unique Identifier : AIDSLINE MED/96387794; Yoshida T; Ito H; Hatano T; Kurata M; Nakanishi T; Inada A; Murata H; Inatomi Y; Matsuura N; Ono K; Nakane H; Noda M; Lang FA; Murata J; Faculty of Pharmaceutical Sciences, Okayama University, Japan.; Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have
Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell leukaemia (ATL) and in HTLV-I carriers.: Clin Endocrinol (Oxf). 1996 Oct;45(4):461-6. Unique Identifier : AIDSLINE MED/97118203; Akamine H; Takasu N; Komiya I; Ishikawa K; Shinjyo T; Nakachi K; Masuda M; Second Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; OBJECTIVE: Human T-lymphotrophic virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukaemia (ATL). This virus is associated with a variety of autoimmune disorders. The possible association between HTLV-I Infection and autoimmune thyroiditis has not been fully studied. We therefore evaluated anti-thyroid
The association of hepatitis C viral infection with porphyria cutanea tarda in the Lothian region of Scotland.: Clin Exp Dermatol. 1996 Jul;21(4):283-5. Unique Identifier : AIDSLINE MED/97119077; Hussain I; Hepburn NC; Jones A; O'Rourke K; Hayes PC; Centre for Liver and Digestive Disorders, Royal Infirmary of; Edinburgh, Scotland.; Porphyria cutanea tarda (PCT) is believed to be associated with reduced hepatic uroporphyrinogen decarboxylase activity and risk factors such as alcohol abuse and medication with oral contraceptives and certain other drugs. Recently it has been suggested that hepatitis C virus (HCV) infection may also be associated wi
Inhibition of classical complement activation by sera from HIV-1-positive patients.: Clin Immunol Immunopathol. 1996 Nov;81(2):114-21. Unique Identifier : AIDSLINE MED/97064122; Burek V; Gerencer M; Department of Clinical Immunology, University Hospital of; Infectious Diseases Dr Fran Mihaljevic, University of Zagreb,; Croatia.; It was shown that gp120/160-coupled CD4+ T cells could be lysed by complement activation, but the target cell lysis was strongly inhibited by the majority of HIV-1-positive sera. Significantly more sera from HIV-1-infected patients with CD4+ T cell count higher than 500 microl (N = 38) as well as from patients with 20
Lymphocyte muscarinic cholinergic activity and PGE2 involvement in experimental Trypanosoma cruzi infection.: Clin Immunol Immunopathol. 1996 Nov;81(2):122-8. Unique Identifier : AIDSLINE MED/97064123; Sterin-Borda L; Gorelik G; Goren N; Cappa SG; Celentano AM; Borda E; CEFYBO-CONICET, Catedras de Microbiologia y Farmacologia,; Facultad de Medicina y de Odontologia, Universidad de Buenos; Aires, Argentina.; In this paper, we demonstrated that the production of PGE2 by CD8+ T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethal Trypanosoma cruzi CA-1 strain could enhance resistance to infection. Treatment in vivo with either atropine or cyclooxygen
Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome.: Clin Immunol Immunopathol. 1996 Nov;81(2):129-35. Unique Identifier : AIDSLINE MED/97064124; Kawabata K; Nagasawa M; Morio T; Okawa H; Yata J; Department of Pediatrics, School of Medicine, Tokyo Medical and; Dental University, Japan.; Cell surface CD8 molecules exist as either alpha/alpha homodimers or alpha/beta heterodimers, and most CD8+ T cells that undergo differentiation in the thymus express alpha/beta heterodimers. CD8 molecules on peripheral blood lymphocytes of patients with Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency dis
Serum and secretory IgA from HIV-infected individuals mediate antibody-dependent cellular cytotoxicity.: Clin Immunol Immunopathol. 1996 Nov;81(2):182-90. Unique Identifier : AIDSLINE MED/97064131; Black KP; Cummins JE Jr; Jackson S; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170, USA.; The potential function of IgA anti-HIV antibodies in mediation of antibody-dependent cellular cytotoxicity (ADCC) was investigated in this study. Serum IgA isolated from HIV-seropositive subjects in stage B3 or C3 and from healthy seronegative individuals was compared to IgG and whole serum for the ability to mediate
HIV disease in children is associated with a selective decrease in CD23+ and CD62L+ B cells.: Clin Immunol Immunopathol. 1996 Nov;81(2):191-9. Unique Identifier : AIDSLINE MED/97064132; Rodriguez C; Thomas JK; O'Rourke S; Stiehm ER; Plaeger S; Department of Pediatrics, UCLA School of Medicine, Los Angeles,; California 90095, USA.; We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude
Comparison of the Vbeta repertoire in peripheral blood and in lymph nodes of HIV-infected subjects reveals skewed usage predominantly in CD8+ T cells.: Clin Immunol Immunopathol. 1996 Nov;81(2):200-9. Unique Identifier : AIDSLINE MED/97064133; Carbonari M; Cibati M; Pesce AM; Dell'Anna L; D'Offizi G; Angelici A; Uccini S; Fiorilli M; Department of Clinical Medicine, University of Rome La Sapienza,; Italy.; Perturbations of the repertoire of variable-beta (Vbeta) regions of the T cell receptor have been observed in patients infected by HIV and have been attributed to stimulation by viral antigens or superantigens. We further sought for traces of HIV-induced perturbations by comparing Vbeta repertoire in peripheral blood
Abnormalities of CD45 isoform expression in HIV infection.: Clin Immunol Immunopathol. 1996 Nov;81(2):210-4. Unique Identifier : AIDSLINE MED/97064134; Mahalingam M; Pozniak A; McManus TJ; Senaldi G; Vergani D; Peakman M; Department of Immunology, King's College Hospital, London, United; Kingdom.; Using monoclonal antibodies against CD45, CD45RA, CD45RB, and CD45RO, the surface density of expression and proportions of different CD45 isoforms were analyzed on CD4+ and CD8+ T lymphocyte subsets in HIV+ patients and controls. Analysis of the relative specific fluorescence (RSF) of CD45 isoforms showed a significan
Volumetric capillary cytometry: a new method for absolute cell enumeration.: Cytometry. 1996 Mar 1;23(3):177-86. Unique Identifier : AIDSLINE MED/97077010; Dietz LJ; Dubrow RS; Manian BS; Sizto NL; Biometric Imaging, Mountain View, California 94043, USA.; This article describes a novel cytometry system that is capable of imaging, identifying, and counting populations of fluorescently labeled cells within a precisely known volume of unlysed whole blood contained in a precision capillary. The whole blood is reacted with dye-labeled antibodies directed at cell surface ant
Improved four-color flow cytometry method using fluo-3 and triple immunofluorescence for analysis of intracellular calcium ion ([Ca2+]i) fluxes among mouse lymph node B- and T-lymphocyte subsets.: Cytometry. 1996 Mar 1;23(3):205-17. Unique Identifier : AIDSLINE MED/97077013; Greimers R; Trebak M; Moutschen M; Jacobs N; Boniver J; Laboratory of Pathological and Cytological Anatomy, University; Hospital of Liege, Belgium.; A visible-light, dual-laser, flow cytometric method was developed for the simultaneous analysis of intracellular ionized calcium concentration ([Ca2+]i) and three cell-surface markers (CD4, CD8, and Thy-1.2 antigens) by using the calcium probe fluo-3 and using R-phycoerythrin (PE), peridinin chlorophyll-alpha protein
[AIDS patients for pain therapy often have to rely on an opiate (news)]: Dtsch Med Wochenschr. 1996 Nov 15;121(46):A45. Unique Identifier : AIDSLINE MED/97128153
Tissue-specific self-peptides bound by major histocompatibility complex class I molecules of a human pancreatic beta-cell line.: Diabetes. 1996 Dec;45(12):1761-5. Unique Identifier : AIDSLINE MED/97081081; Papadopoulos KP; Colovai AI; Maffei A; Jaraquemada D; Suciu-Foca N; Harris PE; Department of Medicine, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; The process of beta-cell destruction in IDDM is mediated, in part, by CD8+ T-cells. Structural characterization of HLA-I-bound self-peptides presented by the human beta-cell line HP-62 was performed to identify possible tissue-specific autoantigens in the context of CD8+ T-cell/HLA-I interactions. The sequences of the
American Gastroenterological Association medical position statement: guidelines for the management of malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection.: Gastroenterology. 1996 Dec;111(6):1722-3. Unique Identifier : AIDSLINE MED/97098214
AGA technical review: malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection.: Gastroenterology. 1996 Dec;111(6):1724-52. Unique Identifier : AIDSLINE MED/97098215; Wilcox CM; Rabeneck L; Friedman S; Department of Medicine, University of Alabama at Birmingham, USA.
Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1.: Gene. 1996 Oct 31;178(1-2):7-13. Unique Identifier : AIDSLINE MED/97080539; Wang L; Mukherjee S; Narayan O; Zhao LJ; Marion Merrell Dow Foundation, Department of Microbiology,; Molecular Genetics and Immunology, University of Kansas Medical; Center, Kansas City 66160-7424, USA.; Human immunodeficiency virus type 1 (HIV-1) replicates productively in vitro in CD4(+)-T cells and/or macrophages. In the host, however, HIV-1 replication may be restricted by the quiescence of susceptible cells. Vpr is a 15-kDa late viral gene product, which is assembled in the virion and suspected to enhance HIV-1 r
[AIDS as a social problem]: Gig Sanit. 1996 Sep-Oct;(5):40-2. Unique Identifier : AIDSLINE MED/97061985; Sidorenko GI; Vashkova VV; Mozhaev EA; Rotova EG
A cervical teratoma with invasive squamous cell carcinoma in an HIV-infected patient: a case report.: Gynecol Oncol. 1996 Mar;60(3):475-9. Unique Identifier : AIDSLINE MED/96370764; Bell MC; Schmidt-Grimminger DC; Connor MG; Alvarez RD; Department of Obstetrics and Gynecology, University of Alabama at; Birmingham 35233, USA.; HIV infection among women is increasing in the United States . Since January 1993, cervical cancer has been considered an AIDS-defining illness. We report a rare case of squamous cell carcinoma arising in a teratoma of the uterine cervix in an HIV-infected patient. This patient was trea
Invasive vulvar carcinoma in two women infected with human immunodeficiency virus.: Gynecol Oncol. 1996 Mar;60(3):500-3. Unique Identifier : AIDSLINE MED/96370771; Wright TC; Koulos JP; Liu P; Sun XW; Department of Pathology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; This report presents two HIV-infected women who developed invasive squamous cell carcinoma of the vulva. One patient was diagnosed with Stage II vulvar cancer 4 years after surgical excision of VIN. This patient underwent a hemivulvectomy and external-beam radiation therapy, but has subsequently developed recurrent vu
[Atypical mycoses--also a sequela of medical progress (interview by Dr. rer. nat. Anita Schweiger)]: Fortschr Med. 1996 Aug 20;114(22-23):14-5. Unique Identifier : AIDSLINE MED/96415331; Mayser P
Assessment of adult sibling grief: a review of measurement issues.: Hosp J. 1996;11(1):1-18. Unique Identifier : AIDSLINE MED/97077741; Robinson L; Pickett M; Over the past decade hospice care has been delivered to an increasing population of persons with Acquired Immunodeficiency Syndrome (PWAS) and their families. Adult siblings likely comprise a large number of these surviving family members. Investigations that examine sibling bereavement are scarce (Osterweis, Solomon
Quantifying phagocytosis of Mycobacterium avium complex by human monocytes in whole blood.: Immunol Cell Biol. 1996 Aug;74(4):306-12. Unique Identifier : AIDSLINE MED/97026000; Hewish MJ; Meikle AM; Hunter SD; Crowe SM; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; Studies of phagocytic efficiency in cells of the macrophage lineage have assumed additional importance since the discovery that HIV infection of these cells impairs their immune function. A rapid method has been developed for measuring phagocytosis of the opportunistic pathogen Mycobacterium avium complex by human mon
Anal and cervical abnormality in women--prediction by human papillomavirus tests.: Int J Cancer. 1996 Nov 27;68(5):559-64. Unique Identifier : AIDSLINE MED/97092714; Melbye M; Smith E; Wohlfahrt J; Osterlind A; Orholm M; Bergmann OJ; Mathiesen L; Darragh TM; Palefsky JM; Department of Epidemiology Research, Statens Serum Institut,; Copenhagen, Denmark. mmelbye@desc.ssi.dk; A total of 151 women at risk of human immunodeficiency virus infection were investigated, to study the strength of the association between cervix and anus regarding the presence of HPV and cytological abnormality. An equal percentage of women had abnormal cervical (12.2%) and anal (12.1%) Papanicolaou smears. HPV meas
Psychodynamic group therapy with adolescents: exploration of HIV-related risk taking.: Int J Group Psychother. 1996 Apr;46(2):229-53. Unique Identifier : AIDSLINE MED/97089856; Henry RM; Department of Psychology, University of Wollongong, Australia.; Recent research shows that adolescents are a high-risk group for HIV infection, and that educational campaigns designed to reduce risk taking concerning HIV/AIDS have been largely ineffective with this population. It is probable that irrational psychodynamic processes underlie this risky behavior. In order to explore
Focusing on living: attitudinal approaches of long-term survivors of AIDS.: Issues Ment Health Nurs. 1996 Sep-Oct;17(5):395-407. Unique Identifier : AIDSLINE MED/97077772; Barroso J; This naturalistic study reports the attitudinal approaches of long-term survivors of AIDS. Ethnographic interviewing techniques were employed to interview a purposive sample of 14 men and 6 women who had had AIDS for at least 3 years and who were living in the Tampa/St. Petersburg, FL, area. As part of a larger study
Teen perspectives on HIV and the relevance of Hawaii's health providers.: Hawaii Med J. 1996 Oct;55(10):205-11. Unique Identifier : AIDSLINE MED/97097500; Bidwell RJ; Mueller CW; Mann E; Mew S; Goo C; Dunbar H; McGrady G; Vera M; Liebow E; Lovely RH; Department of Pediatrics, John A. Burns School of Medicine,; University of Hawaii, Honolulu 96826, USA.; Based on focus group interviews with adolescents from an urban Honolulu community, the present article describes how these adolescents view HIV, HIV-prevention and the role of health care providers in addressing HIV-related needs. Although medical providers are known to be knowledgeable experts in a variety of health
Safe intravenous antibiotic therapy at home: experience of a UK based programme.: J Antimicrob Chemother. 1996 May;37(5):1023-9. Unique Identifier : AIDSLINE MED/96346916; Kayley J; Berendt AR; Snelling MJ; Moore H; Hamilton HC; Peto TE; Crook DW; Conlon CP; East Oxford Health Centre, UK.; Outpatient i.v. antibiotic therapy is well developed in the United States , largely because of pressures from third-party payers to reduce costs of medical care. We have developed an outpatient i.v. antibiotic programme in Oxford, that has evolved from a desire to provide high quality i
Fluconazole plus allopurinol in treatment of visceral leishmaniasis [letter]: J Antimicrob Chemother. 1996 May;37(5):1042-3. Unique Identifier : AIDSLINE MED/96346924; Torrus D; Boix V; Massa B; Portilla J; Perez-Mateo M
Current therapeutic approaches to cryptosporidiosis in immunocompromised patients.: J Antimicrob Chemother. 1996 May;37(5):871-80. Unique Identifier : AIDSLINE MED/96346899; Hoepelman AI; Department of Medicine, University Hospital, Utrecht, The; Netherlands.; Cryptosporidium parvum is a protozon which can cause a severe debilitating disease in immunocompromised patients. Animal models show that cellular immunity is the most important factor protecting against the development of the disease, but patients with a humoral immune deficiency are also at risk. In HIV-infected pat
Arkansas HIV/AIDS report 1983-1996.: J Ark Med Soc. 1996 May;92(12):636-7. Unique Identifier : AIDSLINE MED/97090117
Synthesis of full-length viral DNA in CD4-positive membrane vesicles exposed to HIV-1. A model for studies of early stages of the hiv-1 life cycle.: J Biol Chem. 1996 Nov 8;271(45):28266-70. Unique Identifier : AIDSLINE MED/97067043; Simm M; Pekarskaya O; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center and College of Physicians & Surgeons, Columbia University,; New York, New York 10019, USA. djv@columbia.edu; CD4-positive membrane vesicles (MV) were isolated under isotonic conditions from human T lymphoblastoid cells MT-2 and CEM and tested for their ability to support reverse transcription of viral RNA upon exposure to human immunodeficiency virus, type 1 (HIV-1). MV contained cytoplasms as confirmed by the presence of mi
AIDS-related obsessive compulsive disorder: deconditioning based on fluoxetine-induced inhibition of anxiety.: J Behav Ther Exp Psychiatry. 1996 Mar;27(1):51-6. Unique Identifier : AIDSLINE MED/96409539; Kraus RP; Nicholson IR; Department of Psychiatry, University of Western Ontario, London,; Canada.; Abel s (1993) review of treatments for obsessive compulsive disorder (OCD) indicated that both behavioral treatment (exposure with response prevention, and biological treatment (specific serotonin reuptake inhibiting drugs) are effective. It was recognized that having both available for patients is preferable because
Unusual pattern of enhancement in cryptococcal meningitis: in vivo findings with postmortem correlation.: J Comput Assist Tomogr. 1996 Nov-Dec;20(6):1023-6. Unique Identifier : AIDSLINE MED/97087874; Arnder L; Castillo M; Heinz ER; Scatliff JH; Enterline D; Department of Radiology, University of North Carolina School of; Medicine, Chapel Hill, USA.; Leptomeningeal enhancement on CT and MR imaging studies secondary to cryptococcal meningitis is an uncommon finding. In immunocompromised patients, this meningitis incites only a mild inflammatory reaction and abnormalities are often absent on imaging studies. We recently encountered two patients with cryptococcal men
Comparison of in-phase and opposed-phase GRE and conventional SE MR pulse sequences in T1-weighted imaging of liver lesions.: J Comput Assist Tomogr. 1996 Nov-Dec;20(6):890-7. Unique Identifier : AIDSLINE MED/97087848; Martin J; Sentis M; Puig J; Rue M; Falco J; Donoso L; Zidan A; Unitat de Diagnostic per la Imatge D'Alta Tecnologia (UDIAT),; Consorci Hospitalari del Parc Tauli, Barcelona, Spain.; PURPOSE: Our goal was to compare in-phase (IP) and opposed-phase (OP) GRE and conventional SE sequences in T1-weighted (T1-W) imaging of the liver and to evaluate chemical shift GRE imaging in characterizing liver/lesions for fat content. METHOD: IP and OP T1-W GRE with fast low angle shot (FLASH) technique and T1-W S
Using factor analysis to explore nurses' fear of AIDS in the United States of America.: J Adv Nurs. 1996 Aug;24(2):287-95. Unique Identifier : AIDSLINE MED/97011422; Wang JF; Paterson J; Department of Health Systems, School of Nursing, West Virginia; University, Morgantown 26508-9610, USA.; The purpose of this study was to create a reliable research instrument to test the fear of AIDS (FOA) and to explore the dimension of FOA among nurses. We hypothesized that certain factors, such as physical closeness to AIDS patients or HIV-positive blood and nontolerance of homosexuals, increase fear of AIDS among nu
Effects of group discussion and guided patient care experience on nurses' attitudes towards care of patients with AIDS.: J Adv Nurs. 1996 Aug;24(2):296-302. Unique Identifier : AIDSLINE MED/97011423; Kemppainen JK; Dubbert PM; McWilliams P; University of California, San Francisco, USA.; Nurses with limited experience in caring for persons with AIDS (PWAs) were randomized into three groups receiving an educational session on universal precautions and (a) three group discussion sessions; (b) three sessions of caring for a PWA; or (c) assessment materials only. Both interventions were conducted by a nur
The regulation of the development of CD8 effector T cells.: J Immunol. 1996 Nov 15;157(10):4287-92. Unique Identifier : AIDSLINE MED/97064182; Dutton RW; Trudeau Institute, Saranac Lake, NY 12983, USA.
Impaired signaling in alloantigen-specific CD8+ T cells tolerized in vivo: employing a model of Ld-specific TCR transgenic mice transplanted with allogenic hearts under the cover of a short-term rapamycin treatment.: J Immunol. 1996 Nov 15;157(10):4297-308. Unique Identifier : AIDSLINE MED/97064184; Chen H; Luo H; Xu D; Loh DY; Daloze PM; Veillette A; Qi S; Wu J; Louis-Charles Simard Research Center, Notre-Dame Hospital,; University of Montreal, Canada.; Peripheral tolerance of T cells is necessary because thymic deletion is not complete, and tissue-specific Ags exist outside the thymus. We have reported that persistent Ag is required to maintain peripheral tolerance in vivo. We suspect that the TCR signaling pathway in in vivo tolerized cells is compromised due to co
Lack of IL-12 signaling in human allergen-specific Th2 cells.: J Immunol. 1996 Nov 15;157(10):4316-21. Unique Identifier : AIDSLINE MED/97064186; Hilkens CM; Messer G; Tesselaar K; van Rietschoten AG; Kapsenberg ML; Wierenga EA; Department of Cell Biology and Histology, Academic Medical; Center, University of Amsterdam, The Netherlands.; IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells. In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells. To this aim
Reciprocal cytotoxic T lymphocyte cross-reactivity interactions between two major epitopes within HIV-1 gp160.: J Immunol. 1996 Nov 15;157(10):4399-411. Unique Identifier : AIDSLINE MED/97064196; Shirai M; Kurokohchi K; Pendleton CD; Arichi T; Boyd LF; Takahashi H; Margulies DH; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, Bethesda, MD 20892, USA.; We have observed and analyzed an unexpected cross-reactivity of CD8+ CTL between two nonhomologous peptides of the HIV-1 IIIB gp160 envelope protein, P18 (residues 315-329) and HP53 (834-848, also called TH4.1), in the context of four different class I MHC molecules, Dd, Dp, Dq (or Lq), and H-2u. In strains expressing
Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+NK1.1- T cell population.: J Immunol. 1996 Nov 15;157(10):4421-7. Unique Identifier : AIDSLINE MED/97064198; von der Weid T; Beebe AM; Roopenian DC; Coffman RL; Department of Immunology, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, CA 94304, USA.; Splenic CD4+NK1.1+ T cells have been shown to secrete large and transient amounts of IL-4 mRNA 90 min after i.v. injection of anti-CD3 Ab, suggesting that this novel subset of T cells may induce Th2 responses in the spleen by quickly providing IL-4 at the onset of an immune response. beta2-microglobulin-deficient (bet
Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes.: J Immunol. 1996 Nov 15;157(10):4464-73. Unique Identifier : AIDSLINE MED/97064204; Malarkannan S; Gonzalez F; Nguyen V; Adair G; Shastri N; Department of Molecular and Cell Biology, University of; California, Berkeley 94720, USA.; The identity and abundance of self-peptide/MHC class I complexes that serve as ligands for alloreactive T cells remain largely unknown. Using the Kb-restricted, alloreactive T cells as a probe, the Ag precursor gene, adenosine phosphoribosyl transferase (APRT), was isolated by expression cloning. Its naturally process
The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice.: J Immunol. 1996 Nov 15;157(10):4546-53. Unique Identifier : AIDSLINE MED/97064214; Metwali A; Elliott D; Blum AM; Li J; Sandor M; Lynch R; Noben-Trauth N; Weinstock JV; Department of Internal Medicine, University of Iowa, Iowa City; 52242, USA.; IL-4 plays an important role in polarizing inflammation toward a Th2 response. It remains uncertain, however, whether IL-4 also serves to prevent expression of Th1 inflammation. Therefore, using a genetically pure C57BL/6 IL-4-deficient mouse, we studied the role of IL-4 in regulating the production of IFN-gamma and T
Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production.: J Immunol. 1996 Nov 15;157(10):4602-8. Unique Identifier : AIDSLINE MED/97064220; Chensue SW; Warmington KS; Ruth JH; Sanghi PS; Lincoln P; Kunkel SL; Department of Pathology, Veterans Affairs Medical Center, Ann; Arbor, MI 48105, USA.; The present study examined the contribution of monocyte chemotactic protein-1 (MCP-1) to granulomatous inflammation mediated by Th1- and Th2-related cytokines. Types 1 and 2 lung granulomas (GR) were respectively induced in presensitized CBA mice by embolization of beads coupled to purified protein derivative of Mycob
Selection of T cells reactive against autologous B lymphoblastoid cells during chronic rheumatoid arthritis.: J Immunol. 1996 Nov 15;157(10):4697-706. Unique Identifier : AIDSLINE MED/97064232; David-Ameline J; Lim A; Davodeau F; Peyrat MA; Berthelot JM; Semana G; Pannetier C; Gaschet J; Vie H; Even J; Bonneville M; INSERM Unit 211, Institute of Biology, Nantes, France.; The repertoire and Ag specificity of T cells infiltrating inflamed joints from a chronic rheumatoid arthritis (RA) patient were studied in detail. Repertoire analysis demonstrated a reduced clonality of joint-infiltrating lymphocytes (JIL) as compared with patient s PBL, which was presumably due to an intra-articular
IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice.: J Immunol. 1996 Dec 1;157(11):4746-50. Unique Identifier : AIDSLINE MED/97098698; Szalay G; Ladel CH; Blum C; Kaufmann SH; Department of Immunology, University of Ulm, Germany.; Successful control of infectious disease depends on aquisition of an appropriate protective immune response. IFN-gamma, first produced by NK cells and then by Th1 cells, is central to acquired resistance against intracellular bacteria, including Listeria monocytogenes. In contrast, IL-4 is not generated to a measurabl
Deficient expression of p56(lck) in Th2 cells leads to partial TCR signaling and a dysregulation in lymphokine mRNA levels.: J Immunol. 1996 Dec 1;157(11):4751-61. Unique Identifier : AIDSLINE MED/97098699; al-Ramadi BK; Nakamura T; Leitenberg D; Bothwell AL; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06520, USA.; Activation of T lymphocytes through their TCR is regulated by a delicate balance of phosphorylation and dephosphorylation of protein substrates by protein tyrosine kinases (PTKs) and phosphotyrosyl phosphatases, respectively. One of the earliest steps in the activation pathway is thought to involve the Src family PTKs
Recipient CD8+ cells are responsible for the rapid elimination of allogeneic donor lymphoid cells.: J Immunol. 1996 Dec 1;157(11):4805-10. Unique Identifier : AIDSLINE MED/97098705; Fast LD; Department of Medicine, Rhode Island Hospital and Brown; University School of Medicine, Providence 02903, USA.; Blood transfusion can result in a variety of immunologic responses, including alloimmunization, transfusion-associated graft-versus-host disease, and immunosuppression that results in increased postoperative infection rate, and can also result in increased survival of allografts. One of the many factors influencing th
Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.: J Immunol. 1996 Dec 1;157(11):4811-21. Unique Identifier : AIDSLINE MED/97098706; Fowler DH; Breglio J; Nagel G; Eckhaus MA; Gress RE; Transplantation Therapy Section, Medical Oncology Branch,; National Cancer Institute, National Institutes of Health,; Bethesda, MD 20892, USA.; Allogeneic CD8+ T cells mediate both a graft-vs-leukemia (GVL) effect and graft-vs-host disease (GVHD). To evaluate whether CD8 cells of defined cytokine phenotype differentially mediate these processes, alloreactive donor CD8+ T cells preferentially secreting type I or type II cytokines were generated by alloantigeni
Loss of either CD4+ or CD8+ T cells does not affect the magnitude of protective immunity to an intracellular pathogen, Francisella tularensis strain LVS.: J Immunol. 1996 Dec 1;157(11):5042-8. Unique Identifier : AIDSLINE MED/97098736; Yee D; Rhinehart-Jones TR; Elkins KL; Laboratory of Enteric and Sexually Transmitted Diseases, Division; of Bacterial Products, Center for Biologics Evaluation and; Research, Rockville, MD 20852, USA.; Normal mice readily survive a sublethal intradermal (i.d.) infection with Francisella tularensis live vaccine strain (LVS), a model intracellular bacterium, and are strongly protected against subsequent lethal challenge. However, athymic nu/nu mice, which lack mature alphabeta TCR+ T lymphocytes, succumb to i.d. infec
Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis.: J Immunol. 1996 Dec 1;157(11):5170-7. Unique Identifier : AIDSLINE MED/97098752; Arai K; Yamamura S; Hanyu T; Takahashi HE; Umezu H; Watanabe H; Abo T; Department of Immunology, Niigata University School of Medicine,; Japan.; Murine collagen-induced arthritis (CIA) is known as a T cell-mediated autoimmune disease, although autoantibodies are also suspected to be associated with the onset of the disease. To determine the origin of such T cells in the joints of mice with CIA, their phenotypic properties as well as those of T cells in other i
Experience of human lymphotropic virus type I (HTLV-I) in an East London hospital.: J Infect. 1996 Jan;32(1):33-9. Unique Identifier : AIDSLINE MED/97005238; Hoque S; Kelsey S; van der Walt JD; Breuer J; Department of Medical Microbiology, Royal London Hospital, U.K.; We describe the experience of The Royal London Hospital with human T-cell lymphotropic virus type 1 (HTLV-1) related disease. Twelve patients presented from 1988-1993, nine of them in 1993. None were born in the U.K. and 11 were of West Indian origin. Ten had overt lymphomas, one tropical spastic paraparesis/HTLV-1 as
The epidemiology of HIV infection in Edinburgh related to the injecting of drugs: an historical perspective and new insight regarding the past incidence of HIV infection derived from retrospective HIV antibody testing of stored samples of serum.: J Infect. 1996 Jan;32(1):53-62. Unique Identifier : AIDSLINE MED/97005241; Burns SM; Brettle RP; Gore SM; Peutherer JF; Robertson JR; Regional Virus Laboratory, City Hospital, Edinburgh, U.K.; The pattern of sudden explosive outbreaks of HIV infection among drug users has been seen in several countries but is as yet incompletely understood. The epidemic of injecting drugs in Edinburgh was associated with at least four overlapping epidemics of blood-borne viruses (hepatitis B, C, D and HIV). Only hepatitis B
Toxoplasma pneumonia in Africa [letter]: J Infect. 1996 Jan;32(1):70. Unique Identifier : AIDSLINE MED/97005245; Doherty JF; Chiposi L; Gwanzura L; Mason PR; Beaman MH
Ocular melanoma and human immunodeficiency virus infection.: Insight. 1996 Sep;21(3):86-8. Unique Identifier : AIDSLINE MED/97112813; Abramson DH; Servodidio CA; The number of reports of malignant complications of human immunodeficiency virus infection is increasing. Cutaneous melanoma has been previously reported in five patients with human immunodeficiency virus infection, but no cases of ocular melanoma have been documented. We describe the first case of ocular melanoma rep
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.: J Exp Med. 1996 Nov 1;184(5):1651-61. Unique Identifier : AIDSLINE MED/97079123; Morawetz RA; Gabriele L; Rizzo LV; Noben-Trauth N; Kuhn R; Rajewsky K; Muller W; Doherty TM; Finkelman F; Coffman RL; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Immunoglobulin (Ig) class switching in B cells is regulated by stimuli transduced by cytokines and cell-cell contact. Among these stimuli, interleukin (IL)-4 has been considered an absolute prerequisite for class switching to IgE in the mouse. Here we report that IL-4-deficient (IL-4-/-) and wildtype mice had comparab
Domains of the TCR beta-chain required for early thymocyte development.: J Exp Med. 1996 Nov 1;184(5):1833-43. Unique Identifier : AIDSLINE MED/97079139; Jacobs H; Iacomini J; van de Ven M; Tonegawa S; Berns A; Division of Molecular Genetics, The Netherlands Cancer Institute,; Amsterdam, The Netherlands.; The T cell receptor beta (TCR beta) chain controls the developmental transition from CD4-CD8- to CD4+8+thymocytes. We show that the extracellular constant region and the transmembrane region, but not the variable domain or cytoplasmic tail of the TCR beta chain are required for this differentiation step. TCR beta muta
CD4+ but not CD8+ cells are essential for allorejection.: J Exp Med. 1996 Nov 1;184(5):2013-8. Unique Identifier : AIDSLINE MED/97079156; Krieger NR; Yin DP; Garrison Fathman C; Department of Medicine, Stanford University School of Medicine,; California 94305, USA.; The generation of knockout mice with targeted gene disruption has provided a valuable tool for studying the immune response. Here we describe the use of CD4 and CD8 knockout mice to examine the role of CD4+ and CD8+ cells in initiating allotransplantation rejection. Pretreatment with a brief course of depletive anti-C
Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.: J Exp Med. 1996 Nov 1;184(5):2031-6. Unique Identifier : AIDSLINE MED/97079159; Taylor N; Bacon KB; Smith S; Jahn T; Kadlecek TA; Uribe L; Kohn DB; Gelfand EW; Weiss A; Weinberg K; Division of Research Immunology and Bone Marrow Transplantation,; Children's Hospital, Los Angeles, California 90027, USA.; A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires the association of
Is a case study approach effective in altering the attitudes of student nurses toward AIDS?: J N Y State Nurses Assoc. 1996 Jun;27(2):13-7. Unique Identifier : AIDSLINE MED/97056434; Scherer YK; Dickerson S; Grzankowski J; The effect of a case study approach on attitudes of sophomore nursing students toward caring for patients with AIDS was examined. Pre- and post-program attitudes of 36 students were measured using an AIDS questionnaire. No significant differences were found between pre- and post-program scores on the questionnaire. An
Children's perceptions of peers with AIDS: assessing the impact of contagion information, perceived similarity, and illness conceptualization.: J Pediatr Psychol. 1996 Jun;21(3):321-33. Unique Identifier : AIDSLINE MED/97089328; Maieron MJ; Roberts MC; Prentice-Dunn S; Minnesota Epilsepsy Group, P. A., USA.; Assessed factors that affected acceptance of a hypothetical peer with AIDS. Children in Grades 4-6 read vignettes containing one of four levels of contagion information and one of two levels of perceived similarity. Illness conceptualization was measured as a continuous variable. Results indicated that the type of AID
Impairment of expressive behavior in pediatric HIV-infected patients with evidence of CNS disease.: J Pediatr Psychol. 1996 Jun;21(3):379-400. Unique Identifier : AIDSLINE MED/97089332; Moss HA; Wolters PL; Brouwers P; Hendricks ML; Pizzo PA; Pediatric Branch, National Cancer Institute, Rockville Pike,; Bethesda, Maryland 20892, USA.; Rated observations of videotapes were made of 16 variables representing 5 behavioral domains (task orientation, positive social-emotional, motor skills, expressive speech, and activity) on a sample of 83 HIV-infected children. Comparisons were made on the rated behaviors between children classified as either encephalo
Effect of formulation and processing factors on the characteristics of biodegradable microcapsules of zidovudine.: J Microencapsul. 1996 Sep-Oct;13(5):545-57. Unique Identifier : AIDSLINE MED/97018376; Mandal TK; Shekleton M; Onyebueke E; Washington L; Penson T; College of Pharmacy, Xavier University of Louisiana, New Orleans; 70125, USA.; Biodegradable microcapsules of zidovudine ( AZT ) were prepared using poly-(lactide/glycolide) by the solvent evaporation technique. The objective of this project was to focus on the effect of several formulation and processing factors on the efficiency
Synthesis of alpha-glucosidase I inhibitors showing antiviral (HIV-1) and immunosuppressive activity.: J Pharm Pharmacol. 1996 Feb;48(2):172-8. Unique Identifier : AIDSLINE MED/97089258; van den Broek LA; Kat-Van Den Nieuwenhof MW; Butters TD; Van Boeckel CA; Department of Medicinal Chemistry, N.V. Organon, Netherlands.; The synthesis of a series of analogues of the monosaccharide alpha-glucosidase I inhibitor N-decyl-1-deoxynojirimycin (1) is described. With the incorporation of a single oxygen atom particularly at position seven in the N-decyl side chain, i.e. to give N-7-oxadecyl-dNM (4), the therapeutic ratio (alpha-glucosidase I
College students' judgements and perceptions of persons with AIDS from different risk groups.: J Psychol. 1996 Sep;130(5):527-36. Unique Identifier : AIDSLINE MED/97019010; Johnson ME; Baer AJ; Department of Psychology, University of Alaska Anchorage 99508,; USA.; In this analog study, 104 female and 75 male undergraduate students in the United States read 1 of 8 vignettes that described a person who had just received positive HIV antigen results. The vignettes were identical except for the sex of the person described and his or her risk-group m
Risk behaviors, self-efficacy, and AIDS prevention among adolescents.: J Psychol. 1996 Sep;130(5):537-46. Unique Identifier : AIDSLINE MED/97019011; Goh DS; Primavera C; Bartalini G; Graduate Program in School Psychology, City University of New; York-Queens College, Flushing 11367, USA.; This study was conducted to investigate risk behaviors and AIDS-preventive variables in high school adolescents. One hundred fifty-two students in Grades 10 through 12 were administered an AIDS-related behavior questionnaire and the Attitudes Toward AIDS Scale-High School Version (ATAS-HS; Goh, 1992). The results indi
Expression of membrane form of the pregnancy associated protein TJ6 on decidual lymphocytes in the first trimester of pregnancy.: J Reprod Immunol. 1996 Feb;30(1):17-27. Unique Identifier : AIDSLINE MED/97077598; Rubesa G; Beaman KD; Beer AE; Haller H; Rukavina D; Department of Physiology and Immunology, University of Rijeka,; Croatia.; TJ6, a newly described protein produced locally in the uterine decidua during pregnancy, may be involved in maintaining a unique immunological environment at the maternal-fetal interface. The aim of this study was to determine whether TJ6 is expressed as membrane form on decidual lymphocytes (DL), to define the phenot
HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity.: J Mol Biol. 1996 Nov 22;264(1):20-31. Unique Identifier : AIDSLINE MED/97107524; Yin MJ; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center Dallas 75235-8594, USA.; The human T-cell leukemia virus type I (HTLV-I) transactivator protein Tax is critical for the activation of viral gene expression and the transformation of T-lymphocytes. Tax activation of HTLV-I gene expression is mediated by three highly homologous regulatory elements known as 21 bp repeats which bind the transcrip
HIV-1 reverse transcriptase discriminates against non-self tRNA primers.: J Mol Biol. 1996 Nov 29;264(2):243-54. Unique Identifier : AIDSLINE MED/97109094; Oude Essink BB; Das AT; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.; The interactions between the Reverse Transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) and the natural tRNA(Lys3) primer for initiation of viral DNA synthesis were examined. We constructed a set of HIV-1 RNA templates in which the wild-type primer binding site (PBS(Lys3)) is replaced by sequences compl
Oligonucleotide inhibitors of Taq DNA polymerase facilitate detection of low copy number targets by PCR.: J Mol Biol. 1996 Nov 29;264(2):268-78. Unique Identifier : AIDSLINE MED/97109096; Dang C; Jayasena SD; NeXstar Pharmaceuticals Inc., Boulder, CO 80301, USA.; A random sequence library of single stranded DNA was screened to isolate sequences with high affinity for Thermus aquaticus DNA polymerase (Taq pol), a thermostable enzyme commonly used in the polymerase chain reaction (PCR). Selected oligonucleotide sequences bound Taq pol with dissociation constants in the low picom
alpha-Interferon-2b treatment for chronic hepatitis-B infection in children with cancer.: J Trop Pediatr. 1996 Oct;42(5):262-6. Unique Identifier : AIDSLINE MED/97091220; Cetingul N; Kavakli K; Vergin C; Oztop S; Nisli G; Aydogdu S; Ozacar T; Bilgic A; Yuce G; Yagci R; Department of Pediatric Hematology-Oncology, Ege University,; Faculty of Medicine, Bornova, Izmir, Turkey.; We have evaluated the efficacy of treatment with recombinant Interferon-2b (IFN-2b) in 12 children with cancer who developed chronic hepatitis-B infection. Seven of them had lymphoblastic leukaemia and others had solid tumours. Seven cases were male. Mean age was 10.5 years with a range of 5-16 years. Chronic Hepatiti
Vitamin A deficiency and T-cell subpopulations in children with meningococcal disease.: J Trop Pediatr. 1996 Oct;42(5):287-90. Unique Identifier : AIDSLINE MED/97091225; Semba RD; Bulterys M; Munyeshuli V; Gatsinzi T; Saah A; Chao A; Dushimimana A; Department of Ophthalmology, School of Medicine, Johns Hopkins; University, Baltimore, MD, USA.; Although group A meningococcal disease is a major cause of child morbidity and mortality in sub-Saharan Africa, little is known about vitamin A status and T-cell subpopulations in affected children. A prospective study of vitamin A levels and T-cell subpopulations was conducted in 41 children hospitalized for meningoc
A source of glycosylated human T-cell lymphotropic virus type 1 envelope protein: expression of gp46 by the vaccinia virus/T7 polymerase system.: J Virol. 1996 Nov;70(11):7349-59. Unique Identifier : AIDSLINE MED/97048012; Arp J; LeVatte M; Rowe J; Perkins S; King E; Leystra-Lantz C; Foung SK; Dekaban GA; Gene Therapy and Molecular Virology Group, John P. Robarts; Research Institute, London, Ontario, Canada.; Heterologous expression of the human T-cell lymphotropic virus type 1 (HTLV-1) envelope surface glycoprotein (gp46) in a vaccinia virus/T7 polymerase system resulted in the production of authentic recombinant gp46. Five differentially glycosylated forms of the surface envelope protein were produced by this mammalian s
Tumor necrosis factor alpha inhibits entry of human immunodeficiency virus type 1 into primary human macrophages: a selective role for the 75-kilodalton receptor.: J Virol. 1996 Nov;70(11):7388-97. Unique Identifier : AIDSLINE MED/97048016; Herbein G; Montaner LJ; Gordon S; Sir William Dunn School of Pathology, University of Oxford,; United Kingdom.; The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) is readily detected after human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages in vitro and is present in plasma and tissues of patients with AIDS. Previous studies have shown that human recombinant TNFalpha (hrTNFalpha) enhanc
Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.: J Virol. 1996 Nov;70(11):7462-70. Unique Identifier : AIDSLINE MED/97048023; Hu H; Shioda T; Moriya C; Xin X; Hasan MK; Miyake K; Shimada T; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Minato-ku, Japan.; The envelope protein, gp120, of human immunodeficiency virus type 1 (HIV-1) is heavily glycosylated and sialylated. The heavy sialylation greatly affects the physical properties of the protein, as it resolves into a wide acidic pH range despite the basic pI value predicted for its polypeptide backbone (B. S. Stein and
The oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae.: J Virol. 1996 Nov;70(11):7478-84. Unique Identifier : AIDSLINE MED/97048025; Shnyreva M; Munder T; Department of Cell and Molecular Biology, Hans-Knoll-Institut; fur Naturstoff-Forschung e.V., Jena, Germany.; The transcription factor Tax of the oncogenic human T-cell leukemia virus type 1 is likely to be responsible for viral replication in the host organism and for the induction of proliferation in infected cells. To investigate Tax-mediated transcription in vivo, we expressed Tax as well as CREB in Saccharomyces cerevisi
Anergic TH1 clones specific for hepatitis B virus (HBV) core peptides are inhibitory to other HBV core-specific CD4+ T cells in vitro.: J Virol. 1996 Nov;70(11):7540-8. Unique Identifier : AIDSLINE MED/97048032; Diepolder HM; Jung MC; Wierenga E; Hoffmann RM; Zachoval R; Gerlach TJ; Scholz S; Heavner G; Riethmuller G; Pape GR; Institute for Immunology, University of Munich, Germany.; A strong and transient hepatitis B virus core (HBc)-specific CD4+ T-cell response has been shown to be associated with viral elimination in acute self-limited hepatitis B but to be absent in chronic hepatitis B. So far, little is known about immunological mechanisms involved in the regulation of the HBc-specific CD4+
Feline immunodeficiency virus vaccination: characterization of the immune correlates of protection.: J Virol. 1996 Nov;70(11):7561-8. Unique Identifier : AIDSLINE MED/97048034; Hosie MJ; Flynn JN; MRC Retrovirus Research Laboratory, Department of Veterinary; Pathology, University of Glasgow, Bearsden, United Kingdom.; m.hosie@vet.gla.ac.uk.; Whole inactivated virus (WIV) vaccines derived from the FL4 cell line protect cats against challenge with feline immunodeficiency virus (FIV). To investigate the correlates of protective immunity induced by WIV, we established an immunization regimen which protected a proportion of the vaccinates against challenge. A
Progression to persistent lymphocytosis and tumor development in bovine leukemia virus (BLV)-infected cattle correlates with impaired proliferation of CD4+ T cells in response to gag- and env-encoded BLV proteins.: J Virol. 1996 Nov;70(11):7584-93. Unique Identifier : AIDSLINE MED/97048037; Orlik O; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin--Madison, 53706, USA.; The mechanism of leukemogenesis and persistent lymphocytosis (PL; benign expansion of B lymphocytes) in cattle infected with bovine leukemia virus (BLV; a retrovirus closely related to human T-cell leukemia virus type 1) is unknown; however, the immune system likely plays an important role in controlling the outcome o
Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo.: J Virol. 1996 Nov;70(11):7603-13. Unique Identifier : AIDSLINE MED/97048039; Bagnarelli P; Valenza A; Menzo S; Sampaolesi R; Varaldo PE; Butini L; Montroni M; Perno CF; Aquaro S; Mathez D; Leibowitch J; Balotta C; Clementi M; Istituto di Microbiologia, Universita di Ancona, Italy.; The dynamics of human immunodeficiency virus type 1 (HIV-1) transcription was analyzed in vitro and in vivo by using a specific molecular approach which allows accurate quantitation of the different classes of viral mRNAs. Unspliced (US) and multiply spliced (MS) HIV-1 transcripts were assayed by competitive reverse t
Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: evidence of differential tropism.: J Virol. 1996 Nov;70(11):7654-62. Unique Identifier : AIDSLINE MED/97048044; Strizki JM; Albright AV; Sheng H; O'Connor M; Perrin L; Gonzalez-Scarano F; Department of Neurology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6146, USA.; To ascertain whether viruses present at the time of primary viremia can infect the central nervous system and to determine if microglial tropism is distinct from tropism for monocyte-derived macrophages (MDM), 27 human immunodeficiency virus type 1 (HIV-1) isolates obtained from acutely infected individuals, as well a
In vivo transcriptional regulation of the human immunodeficiency virus in the central nervous system in transgenic mice.: J Virol. 1996 Nov;70(11):7686-94. Unique Identifier : AIDSLINE MED/97048048; Kurth J; Buzy JM; Lindstrom L; Clements JE; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205, USA.; Human immunodeficiency virus type 1 (HIV-1) causes infections of the central nervous system (CNS) and has been implicated as the causative agent of AIDS-associated encephalopathy and the AIDS dementia complex. The development of in vivo models of HIV-1-mediated gene expression has
Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.: J Virol. 1996 Nov;70(11):7706-12. Unique Identifier : AIDSLINE MED/97048050; Gargano N; Biocca S; Bradbury A; Cattaneo A; International School for Advanced Studies, Trieste, Italy.; We describe in this paper the binding and biochemical properties of two human antibody fragments directed against the human immunodeficiency virus type 1 reverse transcriptase (RT). These fragments were isolated from a synthetic combinatorial library of human Fab antibody fragments displayed on the surface of filament
Cytotoxic T-lymphocyte responses to cytomegalovirus in normal and simian immunodeficiency virus-infected rhesus macaques.: J Virol. 1996 Nov;70(11):7725-33. Unique Identifier : AIDSLINE MED/97048052; Kaur A; Daniel MD; Hempel D; Lee-Parritz D; Hirsch MS; Johnson RP; Division of Immunology, New England Regional Primate Center,; Southborough, Massachusetts 01772, USA.; Disseminated cytomegalovirus ( CMV ) infection is a frequent occurrence in human immunodeficiency virus-infected humans and in simian immunodeficiency virus (SIV)-infected rhesus macaques. Rhesus macaques are a suitable animal
Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.: J Virol. 1996 Nov;70(11):7734-43. Unique Identifier : AIDSLINE MED/97048053; Ott DE; Coren LV; Kane BP; Busch LK; Johnson DG; Sowder RC 2nd; Chertova EN; Arthur LO; Henderson LE; AIDS Vaccine Program, National Cancer Institute, Frederick Cancer; Research and Development Center, Maryland 21702-1201, USA.; ott@avpvx1.ncifcrf.gov.; We have identified three types of cytoskeletal proteins inside human immunodeficiency virus type 1 (HIV-1) virions by analyzing subtilisin-digested particles. HIV-1 virions were digested with protease, and the treated particles were isolated by sucrose density centrifugation. This method removes both exterior viral pr
High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.: J Virol. 1996 Nov;70(11):7752-64. Unique Identifier : AIDSLINE MED/97048055; Mariani R; Kirchhoff F; Greenough TC; Sullivan JL; Desrosiers RC; Skowronski J; Cold Spring Harbor Laboratory, New York 11724, USA.; A large number of nef alleles were obtained from peripheral blood mononuclear cells (PBMC) of four long-term nonprogressing survivors of human immunodeficiency virus type 1 (HIV-1) infection and from five individuals with progressive HIV-1 infection. These primary nef alleles were characterized by DNA sequence analysi
Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.: J Virol. 1996 Nov;70(11):7765-72. Unique Identifier : AIDSLINE MED/97048056; Junker U; Escaich S; Plavec I; Baker J; McPhee F; Rose JR; Craik CS; Bohnlein E; Progenesys Program at Systemix, Palo Alto, California 94304, USA.; The enzymatic activity of the human immunodeficiency type 1 (HIV-1) protease (PR) is crucial to render HIV-1 virions mature and infectious. Hence, genetic intervention strategies based on trans-dominant (td) variants of the HIV-1 PR might be an alternative to current pharmacological and gene therapy regimens for AIDS.
Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.: J Virol. 1996 Nov;70(11):7773-82. Unique Identifier : AIDSLINE MED/97048057; Chen W; Qin H; Chesebro B; Cheever MA; Division of Oncology, Department of Medicine, University of; Washington, Seattle 98195, USA. wchen@cesmtp.ccf.org.; FBL-3 is a highly immunogenic murine leukemia of C57BL/6 origin induced by Friend murine leukemia virus (MuLV). Immunization of C57BL/6 mice with FBL-3 readily elicits CD8+ cytotoxic T lymphocytes (CTL) capable of lysing FBL-3 as well as syngeneic leukemias induced by Moloney and Rauscher MuLV. The aim of this current
Generation of atypical pulmonary inflammatory responses in BALB/c mice after immunization with the native attachment (G) glycoprotein of respiratory syncytial virus.: J Virol. 1996 Nov;70(11):7783-91. Unique Identifier : AIDSLINE MED/97048058; Hancock GE; Speelman DJ; Heers K; Bortell E; Smith J; Cosco C; Department of Immunology, Lederle-Praxis Biologicals, Inc., West; Henrietta, New York 14586-9728, USA.; The feasibility of using the highly purified native attachment (G) protein in a subunit vaccine against respiratory syncytial virus (RSV) was examined in a murine model with or without the fusion (F) protein of RSV and the adjuvant QS-21. The studies established that QS-21 was more potent than AIOH as an adjuvant for
Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro.: J Virol. 1996 Nov;70(11):7792-803. Unique Identifier : AIDSLINE MED/97048059; Chang J; Naif HM; Li S; Sullivan JS; Randle CM; Cunningham AL; Virology Department, ICPMR, Westmead Hospital, University of; Sydney, National Centre in HIV Research, New South Wales,; Australia.; Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy
Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization.: J Virol. 1996 Nov;70(11):7827-32. Unique Identifier : AIDSLINE MED/97048063; Weber J; Fenyo EM; Beddows S; Kaleebu P; Bjorndal A; Department of Communicable Diseases, Imperial College School of; Medicine at St. Mary's, London, United Kingdom.; Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand , Brazil , Rwanda , and Uganda , representing genetic subtypes A, B
Nevirapine-resistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients.: J Virol. 1996 Nov;70(11):7894-9. Unique Identifier : AIDSLINE MED/97048071; Havlir DV; Eastman S; Gamst A; Richman DD; Department of Medicine, University of California, San Diego; 92103, USA. dhavlir@ucsd.edu.; The nonnucleoside reverse transcriptase inhibitor nevirapine rapidly selects for mutant human immunodeficiency virus (HIV) in vivo. The most common mutation occurs at amino acid residue 181 in patients receiving monotherapy. After the initiation of ne
T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells.: J Virol. 1996 Nov;70(11):7958-64. Unique Identifier : AIDSLINE MED/97048078; Rizza P; Santini SM; Logozzi MA; Lapenta C; Sestili P; Gherardi G; Lande R; Spada M; Parlato S; Belardelli F; Fais S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The state of activation of the immune system may be an important factor which renders a host more receptive to human immunodeficiency virus (HIV) and more vulnerable to its effects. To explore this issue with a practical in vivo model, we developed a modified protocol of HIV infection in hu-PBL-SCID mice. First, we as
A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells.: J Virol. 1996 Nov;70(11):7992-8002. Unique Identifier : AIDSLINE MED/97048082; Shahabuddin M; Bentsman G; Volsky B; Rodriguez I; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center, New York, New York 10019, USA.; We characterized in detail the life cycle of human immunodeficiency virus type 1 (HIV-1) in human glioma H4/CD4 cells which stably express transfected CD4 DNA (B. Volsky, K. Sakai, M. Reddy, and D. J. Volsky, Virology 186:303-308, 1992). Infection of cloned H4/CD4 cells with the N1T strain of cell-free HIV-1 (HIV-1/N1
An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine.: J Virol. 1996 Nov;70(11):8010-8. Unique Identifier : AIDSLINE GENBANK/Z31355; Hooker DJ; Tachedjian G; Solomon AE; Gurusinghe AD; Land S; Birch C; Anderson JL; Roy BM; Arnold E; Deacon NJ; AIDS Molecular Biology Laboratory, Macfarlane Burnet Center for; Medical Research, Fairfield, Australia.; Sequencing of the reverse transcriptase (RT) region of 26 human immunodeficiency virus type 1 (HIV-1) isolates from eight patients treated with 3 -azido-3 -deoxythymidine ( AZT ) revealed a mutation at codon 210 from TTG (leucine) to TGG (tryptophan) ex
Postbinding events mediated by human immunodeficiency virus type 1 are sensitive to modifications in the D4-transmembrane linker region of CD4.: J Virol. 1996 Nov;70(11):8019-28. Unique Identifier : AIDSLINE MED/97048085; Moir S; Perreault J; Poulin L; Centre de Recherche en Infectiologie du Centre Hospitalier; Universitaire de Quebec, Canada.; Evidence from both structural and functional studies of the CD4 molecule suggests that several domains, including the transmembrane (TM) domain and the adjoining extracellular region (D4-TM linker), contribute to the post-gp12O-binding events leading to human immunodeficiency virus-mediated membrane fusion. To investi
Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm.: J Virol. 1996 Nov;70(11):8055-63. Unique Identifier : AIDSLINE MED/97048089; Orsini MJ; Debouck CM; Department of Molecular Genetics, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.; We introduced various mutations into the activation and RNA binding domains of human immunodeficiency virus type 1 (HIV-1) Tat in order to develop a novel and potent transdominant Tat protein and to characterize its mechanism of action. The different mutant Tat proteins were characterized for their abilities to activa
Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins.: J Virol. 1996 Nov;70(11):8089-97. Unique Identifier : AIDSLINE MED/97048093; Zhang QK; Boast S; de los Santos K; Begemann M; Goff SP; Department of Microbiology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; Retroviral genomes encoding a portion of the Moloney murine leukemia virus Gag protein fused to portions of the murine axl cDNA were constructed so as to mimic naturally occurring transforming viruses. Virus MA1 retained 5 amino acids of the extracellular domain and the complete transmembrane and intracellular domains
Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.: J Virol. 1996 Nov;70(11):8148-50. Unique Identifier : AIDSLINE MED/97048102; McCarty TC; Chattopadhyay SK; Scherer MT; Fredrickson TN; Hartley JW; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892, USA.; Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenes
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions.: J Virol. 1996 Nov;70(11):8151-4. Unique Identifier : AIDSLINE MED/97048103; Renne R; Lagunoff M; Zhong W; Ganem D; Howard Hughes Medical Institute and Department of Microbiology,; University of California, San Francisco 94143, USA.; The genome of a novel human herpesvirus has been detected in specimens of Kaposi s sarcoma (KS) and in several AIDS-related lymphoproliferative disorders. Here we examine the size and genomic conformation of the DNA of this virus (known as KS-associated herpesvirus or human herpesvirus 8) in latently and lytically inf
Human immunodeficiency virus type 1 capsid formation in reticulocyte lysates.: J Virol. 1996 Nov;70(11):8187-94. Unique Identifier : AIDSLINE MED/97048110; Spearman P; Ratner L; Department of Pediatrics, Vanderbilt University, Nashville,; Tennessee 37232-2581, USA.; The Gag polyprotein of human immunodeficiency virus (HIV) (Pr55Gag) contains sufficient information to direct particle assembly events when expressed within tissue culture cells. HIV Gag proteins normally form particles at a plasma membrane assembly site, in a manner analogous to that of the type C avian and mammalian
Human immunodeficiency virus type 1 subtypes defined by env show high frequency of recombinant gag genes. The UNAIDS Network for HIV Isolation and Characterization.: J Virol. 1996 Nov;70(11):8209-12. Unique Identifier : AIDSLINE MED/97048114; Cornelissen M; Kampinga G; Zorgdrager F; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; Amsterdam, The Netherlands.; Genetic subtypes of human immunodeficiency virus type 1 can be distinguished on the basis of phylogenetic analysis of their envelope (env) gene. A significant proportion of human immunodeficiency virus type 1 strains was retrospectively shown to result from recombination events between viruses belonging genetically to
Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma.: J Virol. 1996 Nov;70(11):8218-23. Unique Identifier : AIDSLINE GENBANK/U52064; Cesarman E; Nador RG; Bai F; Bohenzky RA; Russo JJ; Moore PS; Chang Y; Knowles DM; Department of Pathology, The New York Hospital-Cornell Medical; Center, New York 10021, USA.; A new human herpesvirus was recently identified in all forms of Kaposi s sarcoma (Kaposi s sarcoma-associated herpesvirus [KSHV] or human herpesvirus 8), as well as in primary effusion (body cavity-based) lymphomas (PELs). A 12.3-kb-long KSHV clone was obtained from a PEL genomic library. Sequencing of this clone reve
Transmission of feline immunodeficiency virus in domestic cats via artificial insemination.: J Virol. 1996 Nov;70(11):8224-8. Unique Identifier : AIDSLINE MED/97048117; Jordan HL; Howard J; Sellon RK; Wildt DE; Tompkins WA; Kennedy-Stoskopf S; Department of Microbiology, Pathology, and Parasitology, College; of Veterinary Medicine, North Carolina State University, Raleigh; 27606, USA.; The objective of this study was to determine whether semen from male domestic cats infected with feline immunodeficiency virus (FIV) can transmit virus to females. Twelve inseminations were performed by an intrauterine laparoscopic technique with fresh or cryopreserved electroejaculates from asymptomatic males chronic
Failure of a human immunodeficiency virus type 1 (HIV-1) subtype B-derived vaccine to prevent infection of chimpanzees by an HIV-1 subtype E strain.: J Virol. 1996 Nov;70(11):8229-33. Unique Identifier : AIDSLINE MED/97048118; Girard M; Yue L; Barre-Sinoussi F; van der Ryst E; Meignier B; Muchmore E; Fultz PN; Institut Pasteur, Paris, France.; Generation of an effective vaccine against human immunodeficiency virus type 1 (HIV-1) must overcome problems associated with extensive genetic diversity. Although we previously reported vaccine-induced protection of chimpanzees against infection with an HIV-1 strain different from the one used to make the immunogens,
Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy.: J Virol. 1996 Nov;70(11):8234-40. Unique Identifier : AIDSLINE MED/97048119; Cannon PM; Kim N; Kingsman SM; Kingsman AJ; Retrovirus Molecular Biology Group, Department of Biochemistry,; University of Oxford, United Kingdom.; We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of
Possible role of the V3 domain of gp120 in resistance to an amphotericin B derivative (MS8209) blocking human immunodeficiency virus entry.: J Virol. 1996 Nov;70(11):8247-51. Unique Identifier : AIDSLINE MED/97048121; Pleskoff O; Sol N; Marrakchi H; Serlin M; Seman M; Alizon M; INSERM U.332, Institut Cochin de Genetique Moleculaire, Paris,; France.; MS8209, an amphotericin B derivative blocking human immunodeficiency virus type 1 (HIV-1) entry after CD4 binding, neutralized the HIV-2 strains EHO and ROD10 but not ROD(CEM). In the V3 domain of gp120, ROD(CEM) differed from ROD10 at two positions (a threonine instead of an isoleucine at position 312 and an arginine
Evaluation of tuberculosis control policies using computer simulation [see comments]: JAMA. 1996 Dec 18;276(23):1898-903. Unique Identifier : AIDSLINE MED/97122396; Brewer TF; Heymann SJ; Colditz GA; Wilson ME; Auerbach K; Kane D; Fineberg HV; Channing Laboratory, Brigham and Women's Hospital, Boston, Mass; 02115, USA.; OBJECTIVE: To develop more effective methods to assess tuberculosis (TB) control strategies so we can meet national goals for the elimination of TB in the United States . DESIGN: Using a semi-Markov model that divided the US population into 3 age groups and 18 clinical states based on d
Feedback regulation of T cell development in the thymus.: J Theor Biol. 1996 Jul 21;181(2):157-67. Unique Identifier : AIDSLINE MED/97089685; Mehr R; Perelson AS; Fridkis-Hareli M; Globerson A; Theoretical Division, Los Alamos National Laboratory, NM 87545,; USA. ramit@t10.lanl.gov; Recent findings suggest that mature T cells in the thymus may regulate the growth and differentiation of immature thymocytes. Here we use mathematical modeling and computer simulations to identify the thymocyte subsets that might serve as targets for regulation, and the processes that might be affected by regulation.
[Clinical significance of detecting in peripheral blood giant endothelial cells infected by cytomegalovirus in patients with AIDS (letter)]: Med Clin (Barc). 1996 Sep 7;107(7):277-8. Unique Identifier : AIDSLINE MED/97039170; Reina J; Blanco I; Munar M
New frontiers of immunotherapy for HIV [comment]: Lancet. 1996 Dec 7;348(9041):1531-2. Unique Identifier : AIDSLINE MED/97108550; Haynes BF; Duke Center for AIDS Research, Duke University Medical Center,; Durham, North Carolina 27710, USA.
Randomised trial of MNrgp120 HIV-1 vaccine in symptomless HIV-1 infection [see comments]: Lancet. 1996 Dec 7;348(9041):1547-51. Unique Identifier : AIDSLINE MED/97108555; Eron JJ Jr; Ashby MA; Giordano MF; Chernow M; Reiter WM; Deeks SG; Lavelle JP; Conant MA; Yangco BG; Pate PG; Torres RA; Mitsuyasu RT; Twaddell T; University of North Carolina AIDS Clinical Trial Unit, Chapel; Hill 27599, USA.; BACKGROUND: Most individuals infected with HIV-1 show disease progression despite both cellular and humoral immune responses. We investigated whether immunisation of patients who had symptomless HIV-1 infection with an envelope subcomponent vaccine (MNrgp120) to augment immune response can slow progression of HIV-1 di
World AIDS day aims to combat growing complacence [news]: Lancet. 1996 Dec 7;348(9041):1578. Unique Identifier : AIDSLINE MED/97108563; Ng D
HHV-8 serology and Kaposi's sarcoma [letter]: Lancet. 1996 Dec 7;348(9041):1587-8. Unique Identifier : AIDSLINE MED/97108575; Gompels UA; Kasolo FC
The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents.: Life Sci. 1996;59(23):PL 365-70. Unique Identifier : AIDSLINE MED/97107561; Bourinbaiar AS; Fruhstorfer EC; Metatron, Inc., New York, NY 10003, USA.; emballon@usa.pipeline.com; The suppression of human immunodeficiency virus (HIV) replication by histamine type 2 (H2) receptor antagonists, cimetidine, ranitidine, and famotidine was examined in vitro. The 50% reduction (IC50) in p24 antigen expression caused by the anti-ulcer agent, cimetidine, was observed at 26.8 nM with IC100 at 10 microM.
Deaths among drug abusers in south-east Scotland (1989-1994).: Med Sci Law. 1996 Jul;36(3):231-6. Unique Identifier : AIDSLINE MED/97075700; Bentley AJ; Busuttil A; Forensic Medicine Unit, University of Edinburgh Medical School.; A survey of deaths of chronic drug abusers who came to medico-legal autopsy in the South-east of Scotland revealed a total of 179 fatalities in the six-year period between 1989 and 1994 inclusive. There was an almost linear increase in the number of such deaths reported to the Procurator Fiscal per year over this peri
Evaluation of an HIV/AIDS education program for family-based foster care providers.: Ment Retard. 1996 Apr;34(2):75-82. Unique Identifier : AIDSLINE MED/97089979; Scotti JR; Ujcich KJ; Nangle DW; Weigle KL; Ellis JT; Kirk KS; Vittimberga GL; Giacoletti AM; Carr-Nangle R; Department of Psychology, West Virginia University, Morgantown; 26506-6040, USA.; Because individuals with mental retardation have recently been identified as a group at-risk for developing HIV infection, HIV/AIDS training programs for service providers working with this population are critical. In this study an HIV/AIDS education program for family-based foster care providers was described and eva
[New virostatic drugs, psychopharmaceuticals and cytostatic drugs (editorial)]: Med Monatsschr Pharm. 1996 Sep;19(9):251. Unique Identifier : AIDSLINE MED/96438345
Walk the walk, if you talk the talk [editorial]: Mo Med. 1996 Oct;93(10):622-3. Unique Identifier : AIDSLINE MED/97097579; Thomas JR
Coccidioidomycosis--Arizona, 1990-1995.: MMWR Morb Mortal Wkly Rep. 1996 Dec 13;45(49):1069-73. Unique Identifier : AIDSLINE MED/97126295; Coccidioidomycosis is a systemic infection caused by the inhalation of airborne arthroconidia from Coccidioides immitis, a soil-dwelling fungus found in the southwestern United States , parts of Mexico , and Central and South America. Clinical manifes
Dinitrochlorobenzene is genotoxic by sister chromatid exchange in human skin fibroblasts.: Mutat Res. 1996 Nov 4;371(1-2):105-8. Unique Identifier : AIDSLINE MED/97107615; DeLeve LD; Department of Pharmacology, Hospital for Sick Children, Toronto,; Ont., Canada. deleve@hsc.usc.edu; Dinitrochlorobenzene (DNCB) is clinically efficacious in the therapy of alopecia areata, but its use was limited when it was found to be mutagenic in the Ames test. However, there has been renewed interest in the immunomodulatory benefits of topically applied dinitrochlorobenzene in patients with human immunodeficienc
Decline in HIV infections in Thailand [letter]: N Engl J Med. 1996 Dec 26;335(26):1998; discussion 1999. Unique Identifier : AIDSLINE MED/97115931; Brody S
Decline in HIV infections in Thailand [letter]: N Engl J Med. 1996 Dec 26;335(26):1998; discussion 1999. Unique Identifier : AIDSLINE MED/97115932; Lawless NP
Accidental success with carbamazepine for psoriatic erythroderma [letter]: N Engl J Med. 1996 Dec 26;335(26):1999-2000. Unique Identifier : AIDSLINE MED/97115933; Smith KJ; Skelton HG
[Update on HIV infection in the province of Cosenza. HIV infections and respiratory disease]: Minerva Med. 1996 Jul-Aug;87(7-8):339-46. Unique Identifier : AIDSLINE MED/97085515; Lo Giudice V; Bruni A; Guaglianone L; De Santis S; Plastino A; Leporace L; Cavalcanti P; Giraldi G; Greco LM; Ospedale M. Santo, I Divisione di Pneumologia, Ospedali Riuniti; di Cosenza.; The aim of the present study was to evaluate the incidence of HIV infection and concomitant pathologies, paying special attention to those involving the respiratory tract, in the Province of Cosenza through a retrospective study of patients monitored by the Divisions of Infectious Diseases and Pneumology with the coll
[The lung in AIDS]: Minerva Med. 1996 Jul-Aug;87(7-8):347-54. Unique Identifier : AIDSLINE MED/97085516; Lo Giudice V; Bruni A; Guaglianone L; De Santis S; Plastino A; Leporace L; Cavalcanti P; Giraldi G; Greco LM; Ospedale M. Santo, I Divisione di Pneumologia, Ospedali Riuniti; di Cosenza.; The aim of this study was to underline the important role played by respiratory tract pathologies in HIV-infected subjects and to evaluate the incidence of respiratory pathologies in HIV-positive subjects in the province of Cosenza. After examining recently reported data, the authors analyse the patients studied by th
[Symptomatic efficacy of clotrimazole combined with surgery in the treatment of recurring anal and genital condylomatosis in seropositive and AIDS patients]: Minerva Med. 1996 Sep;87(9):433-5. Unique Identifier : AIDSLINE MED/97099440; Erenbourg L; Capasso G; Divisione di Chirurgia I, Ospedale San Raffaele-Milano.; During their daily surgical activity in Hiv-positive and AIDS patients the authors have seen in surgical treatment of anogenital recurring acuminate condylomata (treated with diatermocoagulation) in 1995 that prescribing elotrimazole ointment in Candida albicans infection of the same regions there was and amelioration
HIV legal update--Part 2.: Nurs Manage. 1996 Nov;27(11):18-9. Unique Identifier : AIDSLINE MED/97112879; Fiesta J; A relatively new type of claim has been asserted by individuals--injury based on their fear of contracting acquired immunodeficiency syndrome (AIDS) by a potential exposure to a person infected with human immunodeficiency virus (HIV). Recognizing this claim could provide employers with an incentive to exclude or isola
Quality of life assessment in pregnant women with the human immunodeficiency virus.: Obstet Gynecol. 1996 Dec;88(6):1016-20. Unique Identifier : AIDSLINE MED/97098304; Larrabee KD; Monga M; Eriksen N; Helfgott A; Department of Obstetrics, Gynecology, and Reproductive Sciences,; University of Texas Health Science Center-Houston Medical School,; Hermann Hospital, USA.; OBJECTIVE: To describe the perceived quality of life and functional status of women with human immunodeficiency virus (HIV) during the antenatal, perinatal, and postpartum periods. METHODS: Medical Outcome Survey-Short Form questionnaires were completed during antenatal visits, 24 hours after delivery, and 6 months po
[Transmission of human immunodeficiency virus type 1 (HIV-1) from mother to child]: Pediatr Pol. 1996 Apr;71(4):339-42. Unique Identifier : AIDSLINE MED/97048784; Rogowska-Szadkowska D; Klinika Obserwacyjno-Zakazna Akademii Medycznej w Bialymstoku.
HIV care in the community needs revision [news]: Nurs Times. 1996 Sep 11-17;92(37):12. Unique Identifier : AIDSLINE MED/97077714; Brocklehurst N; Butterworth T
Age speeds onset of AIDS following HIV infection [news]: Nurs Times. 1996 Sep 18-23;92(38):12. Unique Identifier : AIDSLINE MED/97106370; Pezzotti P; Phillips AN; Dorrucci M
HIV/AIDS. Part I: knowledge for practice.: Nurs Times. 1996 Sep 25-Oct 1;92(39):suppl 1-4. Unique Identifier : AIDSLINE MED/97106369; Macgregor H
HIV/AIDS. Part II: the role of the nurse.: Nurs Times. 1996 Oct 2-8;92(40):suppl 5-8. Unique Identifier : AIDSLINE MED/97106346; Macgregor H
Role of nurses in prevention management and control of infection: report on a TNAI workshop.: Nurs J India. 1996 Jun;87(6):130-4. Unique Identifier : AIDSLINE MED/97086014; Chakravarty S
[Dirofilariasis in France: a case in Languedoc in an HIV-seropositive patient]: Presse Med. 1996 Oct 12;25(30):1372-5. Unique Identifier : AIDSLINE MED/97117974; Basset D; Villain M; Bastien P; Taupin P; Jarry DM; Dedet JP; Laboratoire de Parasitologie-Mycologie, Institut de Botanique,; Montpellier.; Dirofilaria repens is an endemic canine parasite in the Mediterranean area. Human infestation is rare. We observed a case in an HIV-positive patient who presented an ocular filaria which was successfully removed under local anesthesia. In man, filariae may be expulsed without a parasite cycle or complete a growth cycl
[Urinary porphyrin excretion in human immunodeficiency virus infection]: Presse Med. 1996 Oct 26;25(32):1541-5. Unique Identifier : AIDSLINE MED/97110510; Mouly F; Janier M; Nordmann Y; Flageul B; Policlinique de Dermatologie, Hopital Saint-Louis, Paris.; OBJECTIVES: Porphyria cutanea tarda has been reported in about 60 patients with human immunodeficiency virus (HIV) since 1987. We looked for porphyrin metabolism disorders in HIV infected patients without patent porphyria cutanea tarda. METHODS: Urinary porphyrin excretion was measured in 64 patients with an HIV infec
Virus-lymphoid cell interactions [comment]: Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12756-8. Unique Identifier : AIDSLINE MED/97075063; Oldstone MB; Scripps Research Institute, Department of Neuropharmacology, La; Jolla, CA 92037, USA.
Detection of HIV-1 RNA by nucleic acid sequence-based amplification combined with fluorescence correlation spectroscopy.: Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12811-6. Unique Identifier : AIDSLINE MED/97075074; Oehlenschlager F; Schwille P; Eigen M; Department of Biochemical Kinetics, Max Planck Institute for; Biophysical Chemistry, Gottingen, Germany.; Nucleic acid sequence-based amplification (NASBA) has proved to be an ultrasensitive method for HIV-1 diagnosis in plasma even in the primary HIV infection stage. This technique was combined with fluorescence correlation spectroscopy (FCS) which enables online detection of the HIV-1 RNA molecules amplified by NASBA. A
Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals [see comments]: Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13125-30. Unique Identifier : AIDSLINE MED/97075129; Blackbourn DJ; Mackewicz CE; Barker E; Hunt TK; Herndier B; Haase AT; Levy JA; Department of Medicine, University of California, San Francisco; 94143, USA.; Lymphoid tissues from asymptomatic HIV-infected individuals, as compared with symptomatic HIV-infected subjects, show limited histopathological changes and lower levels of HIV expression. In this report we correlate the control of HIV replication in lymph nodes to the non-cytolytic anti-HIV activity of lymphoid tissue
Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors.: Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13152-7. Unique Identifier : AIDSLINE MED/97075134; Balzarini J; Pelemans H; Karlsson A; De ClercQ E; Kleim JP; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant viruses that had acquired the characteristic 184-Ile mut
Protecting fibrinogen with rutin during UVC irradiation for viral inactivation.: Photochem Photobiol. 1996 Apr;63(4):541-6. Unique Identifier : AIDSLINE MED/97088859; Marx G; Mou X; Freed R; Ben-Hur E; Yang C; Horowitz B; Melville Biologics Inc., New York, NY, USA. gmarx@server.nybc.org; Fibrinogen solutions were irradiated with UVC (254 nm) to inactivate contaminating viruses. In order to protect fibrinogen during UVC irradiation, 0.5 mM rutin was added prior to UVC exposure and subsequently removed during processing. Viral kill by 0.1 J/cm2 UVC resulted in the following inactivation values (log 10):
Distress reduction during the structured clinical interview for DSM-III-R.: Psychiatry Res. 1996 Jan 31;59(3):245-9. Unique Identifier : AIDSLINE MED/97083456; Scarvalone PA; Cloitre M; Spielman LA; Jacobsberg L; Fishman B; Perry SW; Department of Psychiatry, Cornell University Medical Center, New; York 10021, USA.; In an attempt to assess the influence of standardized diagnostic interviews on psychological distress in research volunteers, the Visual Analogue Scale (VAS) was used to measure anxiety and depression during the Structured Clinical Interview for DSM-III-R, Non-patient version (SCID). Subjects were 50 adults with conce
Reliability and validity of AIDS victim blaming scales.: Psychol Rep. 1996 Aug;79(1):191-201. Unique Identifier : AIDSLINE MED/97027702; Mulford CL; Lee MY; Sociology Department, Iowa State University, Ames 50011, USA.; Scales were developed to measure the tendencies to blame AIDS victims or the society in which victims live. Data from a sample of 874 students were used to examine the construct validity and reliability of the scales. The list-wise deletion reduced the sample size to the usable sample size of 824. The data showed sati
Ethnic-racial differences in psychological stress related to gay lifestyle among HIV-positive men.: Psychol Rep. 1996 Aug;79(1):303-12. Unique Identifier : AIDSLINE MED/97027718; Siegel K; Epstein JA; Memorial Sloan-Kettering Cancer Center, New York, New York 10021,; USA.; To examine whether there were any ethnic-racial differences among 144 HIV-infected gay men (47 Caucasian, 48 African-American, and 49 Puerto Rican) on psychological stressors related to the gay lifestyle, responses to the Gay Lifestyle Hassles scale were analyzed. The African-American and Puerto Rican men reported sig
Reliability of a knowledge of AIDS scale a replication.: Psychol Rep. 1996 Oct;79(2):529-30. Unique Identifier : AIDSLINE MED/97065584; Nicholas L; Orr N; Daniels P; Centre for Student Counselling, University of the Western Cape,; Bellville, South Africa.; Zimet s knowledge of AIDS scale was completed anonymously by 2,209 university students to assess whether a split-half approach in which items in each half were matched for content would provide better estimates of reliability than other method. Analysis indicates that the odd even Spearman Brown split-half reliability
Liver toxoplasmosis and acquired immunodeficiency syndrome.: Recenti Prog Med. 1996 Jul-Aug;87(7-8):353-5. Unique Identifier : AIDSLINE MED/96428101; Mastroianni A; Coronado O; Scarani P; Manfredi R; Chiodo F; Istituto Malattie Infettive, Policlinico Sant'Orsola,; Universita, Bologna.; We report two rare cases of acute toxoplasmic hepatitis in patients that were serum positive for Human Immunodeficiency Virus (HIV) infection. Although Toxoplasma gondii is the main causative agent in infections of the central nervous system (CNS) in patients with AIDS and is known to cause widely disseminated infecti
Polymerase chain reaction detection of cytomegalovirus and human immunodeficiency virus-1 in the retina of patients with acquired immune deficiency syndrome with and without cotton-wool spots.: Retina. 1996;16(4):305-11. Unique Identifier : AIDSLINE MED/97018774; Gonzalez CR; Wiley CA; Arevalo JF; Garcia RF; Kuppermann BD; Berry C; Freeman WR; UCSD Department of Ophthalmology, Shiley Eye Center, La Jolla, CA; 92093, USA.; PURPOSE: The authors determine the association, if any, between detection of human cytomegalovirus ( CMV ) and human immunodeficiency virus (HIV) nucleic acids and retinal lesions in patients with acquired immune deficiency syn
Cystoid macular edema due to cytomegalovirus retinitis in a patient with acquired immune deficiency syndrome.: Retina. 1996;16(4):343-4. Unique Identifier : AIDSLINE MED/97018782; Weinberg DV; Moorthy RS; Department of Ophthalmology, Northwestern University Medical; School, Chicago, Ilinois, USA.
[Benign tumor of the cavum caused by CD8 lymphocytic infiltration in a patient with HIV infection]: Rev Laryngol Otol Rhinol (Bord). 1996;117(2):145-7. Unique Identifier : AIDSLINE MED/97119114; Bourrel C; Pines E; Malbec D; Boudon P; Herman D; Choudat L; Centre-Hospitalier General Robert Ballanger, Service de; Medecine Interne, Aunay-sous-Bois, France.
[Hemostasis anomalies and human immunodeficiency virus infection: what significance? (editorial)]: Rev Med Interne. 1996;17(9):725-6. Unique Identifier : AIDSLINE MED/97118242; Fuzibet JG
[Hemostasis anomalies and human immunodeficiency virus infection]: Rev Med Interne. 1996;17(9):738-45. Unique Identifier : AIDSLINE MED/97118245; Fezoui H; Garnier G; Taillan B; Cassuto JP; Pesce A; Service de medecine interne II. hematologie, hopital de; Cimiez, Nice, France.; Because hemostasis disorder in HIV infected patients are frequent and have clinical effects, they have aroused the interest of internal medicine. Such anomalies are not yet clearly defined and include various parameters. Thrombocytopenia which is the most widespread and the best documented manifestation, whether of pe
[Epidemiology of invasive mycoses. Experience of a university hospital center in Paris]: Rev Med Interne. 1996;17(9):754-60. Unique Identifier : AIDSLINE MED/97118248; Hennequin C; Service de microbiologie, hopital Necker-Enfants Malades, Paris; France.; The incidence of opportunistic fungal infections have dramatically increased during the past decades. Data from a retrospective study conducted between January 1992 and December 1994 in Necker-Enfants Malades Hospital and a review of the literature were analyzed to assess the main epidemiological features of these inf
[Primary pulmonary arterial hypertension: a rare manifestation of AIDS. Apropos of a case (letter)]: Rev Med Interne. 1996;17(9):774-5. Unique Identifier : AIDSLINE MED/97118253; Duche A; Ducroix JP; Lafon B; Smail A; Rudelli A; Guillaumont MP; Baillet J
Cytokine production in hearts of Trypanosoma cruzi-infected CBA mice: Do cytokine patterns in chronic stage reflect the establishment of myocardial pathology?: Scand J Immunol. 1996 Nov;44(5):421-9. Unique Identifier : AIDSLINE MED/97103220; Sunnemark D; Ulfgren AK; Orn A; Harris RA; Microbiology and Tumorbiology Centre, Karolinska Institute,; Stockholm, Sweden.; The authors analysed cytokine production in hearts of Trypanosoma cruzi-infected CBA-J mice by in situ immunocytochemical staining. Cellular infiltrates were recorded in hearts from both acute and chronic stages, but were not apparent in control hearts. In the acute heart, CD8 cells predominated, with associated produ
Induction of cytotoxic T-cell activity by the protective antigen of Schistosoma mansoni Sm28GST or its derived C-terminal lipopeptide.: Scand J Immunol. 1996 Nov;44(5):485-92. Unique Identifier : AIDSLINE MED/97103228; Pancre V; Gras-Masse H; Delanoye A; Herno J; Capron A; Auriault C; Laboratoire d'Immunologie Cellulaire de l'interface; hote/parasite et de la pathogenese parasitaire, CNRS URA 1854,; Institut Pasteur, France.; In a previous work the authors demonstrated that immunization with Schistosoma mansoni 28-kDa glutathione-S-transferase (Sm28GST) was able to reduce hepatic damage in infected mice and that the adoptive transfer of Sm28GST-specific T cells reproduced the protective effect obtained with the recombinant molecule. In the
CD8+ cells are the main producers of IL10 and IFN gamma after superantigen stimulation.: Scand J Immunol. 1996 Nov;44(5):501-5. Unique Identifier : AIDSLINE MED/97103230; Hoiden I; Moller G; Department of Immunology, Arrhenius Laboratories for Natural; Sciences, Stockholm University, Sweden.; Purified CD8+ T cells were recently shown to produce TH1 as well as TH2 types of cytokines upon restimulation, indicating an important role for these cells in regulation of immune responses. However, it is not known if the CD8+ cells would contribute to cytokine production in the presence of cytokine secreting CD4+ ce
Schizophrenia and HIV.: Schizophr Bull. 1996;22(3):465-73. Unique Identifier : AIDSLINE MED/97027129; Sewell DD; Mission Valley Mental Health Clinic, San Diego Veterans Affairs; Medical Center, CA 92108, USA.; There is very little published information regarding the co-occurrence of human immunodeficiency virus (HIV)-spectrum illness and psychotic illnesses, including schizophrenia, even though their coexistence in the same patient may severely affect the course of both illnesses. Estimates of the frequency of HIV infection
Training and supporting the telephone intake worker for an AIDS prevention counseling study.: Soc Work. 1996 May;41(3):314-9. Unique Identifier : AIDSLINE MED/97090179; Conte CK; Fisher DS; Callahan LE; Roffman RA; Innovative Programs Research Group, Seattle, WA 98105-6020, USA.
HIV/AIDS and suicide: be open.: Soc Work. 1996 May;41(3):324. Unique Identifier : AIDSLINE MED/97090181; Holtby ME
HIV/AIDS and suicide: further precautions.: Soc Work. 1996 May;41(3):325-6. Unique Identifier : AIDSLINE MED/97090182; Mancoske RJ; School of Social Work, Southern University, New Orleans, LA; 70126, USA. Ronm1450.MSN.com
Evaluation of a directly observed six months fully intermittent treatment regimen for tuberculosis in patients suspected of poor compliance.: Thorax. 1996 Nov;51(11):1130-3. Unique Identifier : AIDSLINE MED/97118015; Caminero JA; Pavon JM; Rodriguez de Castro F; Diaz F; Julia G; Cayla JA; Cabrera P; Hospital Ntra. Sra. del Pino, Universidad de Las Palmas de Gran; Canaria, Spain.; BACKGROUND: Although a priority for tuberculosis control is to achieve the maximum cure rate, compliance with chemotherapy in specific high risk groups (homeless, intravenous drug abusers, chronic alcoholics) is usually poor. METHODS: From January 1990 to December 1994 102 patients with tuberculosis (96 pulmonary, six
[Protease inhibitors--miracle drugs against HIV-infection?]: Tidsskr Nor Laegeforen. 1996 Oct 10;116(24):2871-2. Unique Identifier : AIDSLINE MED/97067713; Asjo B; Avdeling for mikrobiologi och immunologi Gades Institutt; Hoyteknologisenteret Universitet i Bergen.
[The HIV proteinase--a target for antiviral agents]: Tidsskr Nor Laegeforen. 1996 Oct 10;116(24):2908-11. Unique Identifier : AIDSLINE MED/97067724; Grinde B; Jonassen TO; Avdeling for virologi Statens institutt for folkehelse, Oslo.; The enormous resources spent on developing inhibitors of the HIV proteinase is finally proving worth while. The FDA in the USA approved saquinavir ( Invirase , Roche) for treatment of AIDS in December 1995, and the presumably even more useful inhib
Amplification of natural regulatory immune mechanisms for transplantation tolerance.: Transplantation. 1996 Nov 15;62(9):1200-6. Unique Identifier : AIDSLINE MED/97086567; Chen ZK; Cobbold SP; Waldmann H; Metcalfe S; Department of Surgery, Addenbrooke's Hospital, University of; Cambridge, United Kingdom.; There is a need to derive donor-specific tolerance in clinical organ transplantation, where potential benefits remain overshadowed by chronic rejection and side effects of continual immunosuppressive therapy. It is known that the mature immune system in mice can be reprogrammed to accept a foreign graft as if it were
Nonprocurement of transplantable organs in a tertiary care hospital: a focus on sociological causes.: Transplantation. 1996 Nov 15;62(9):1224-9. Unique Identifier : AIDSLINE MED/97086572; Durand-Zaleski I; Waissman R; Lang P; Weil B; Foury M; Bonnet F; Center for Sociological Studies in Medicine (CERMES), Paris,; France.; BACKGROUND: The purpose of this study was to investigate prospectively the medical and organizational causes of nonprocurement of transplantable organs and to provide explicit information on the determining factors of family response to donation request. METHODS: Medical causes investigated were age, human immunodefic
Coexistence of Th1- and Th2-type cytokine profiles in anti-CD2 monoclonal antibody-induced tolerance.: Transplantation. 1996 Nov 15;62(9):1285-92. Unique Identifier : AIDSLINE MED/97086584; Krieger NR; Most D; Bromberg JS; Holm B; Huie P; Sibley RK; Dafoe DC; Alfrey EJ; Department of Surgery, Stanford University, California 94305,; USA.; Anti-CD2 monoclonal antibody OX34 has been shown to suppress immunity in rodents in vitro and in vivo. To evaluate the effects of OX34 on vascularized allografts, Lewis (RT1(1)) hearts were transplanted heterotopically into Wistar Furth (RT1(u)) rats. A single 5 mg/kg intraperitoneal dose of OX34 administered at trans
Persistent cough in patients using an urban chest clinic in Malawi.: Trop Doct. 1996 Oct;26(4):165-7. Unique Identifier : AIDSLINE MED/97091564; Nwanyanwu O; Nyangulu D; Salaniponi F; Ministry of Health, Lilongwe, Malawi.; In many sub-Saharan African countries, tuberculosis (TB) cases have been increasing steadily since 1985. In Malawi , they have increased by 38% from 1990 to 1993, and extrapulmonary TB increased by 79%. Among 385 patients with a history of persistent cough presumed to be TB, 360 (94
Immunization with plasmid DNA encoding for the measles virus hemagglutinin and nucleoprotein leads to humoral and cell-mediated immunity.: Virology. 1996 Nov 15;225(2):293-9. Unique Identifier : AIDSLINE MED/97078790; Cardoso AI; Blixenkrone-Moller M; Fayolle J; Liu M; Buckland R; Wild TF; INSERM Unit 404 Immunity and Vaccination, Institut Pasteur de; Lyon, France.; We have evaluated the DNA vaccination strategy for measles virus (MV) hemagglutinin (HA) and nucleoprotein (NP) genes. Plasmids encoding either the MV, HA, or NP proteins inoculated intramuscularly into Balb/c mice induced both humoral and CTL class I restricted responses. Antibody responses were not increased by mult
A specific RNA structural motif mediates high affinity binding by the HIV-1 nucleocapsid protein (NCp7).: Virology. 1996 Nov 15;225(2):306-15. Unique Identifier : AIDSLINE MED/97078792; Allen P; Collins B; Brown D; Hostomsky Z; Gold L; University of Colorado at Boulder, Department of Molecular,; Cellular and Developmental Biology, 80309-0347, USA.; Current research indicates that the nucleocapsid protein (NCp7) of human immunodeficiency virus type 1 (HIV-1) interacts with a variety of RNA substrates during the progression of the viral life cycle. The RNA features specifically recognized by the protein, however, have yet to be identified. SELEX was used to genera
Paracrine activation of the HIV-1 LTR promoter by the viral Tat protein is mechanistically similar to trans-activation within a cell.: Virology. 1996 Nov 15;225(2):316-27. Unique Identifier : AIDSLINE MED/97078793; Verhoef K; Klein A; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.; The HIV-1 Tat protein activates transcription of the viral LTR promoter through interaction with the nuclear transcription machinery of the host cell. Tat can also activate the LTR promoter in a paracrine or inter-cellular manner by a yet unknown mechanism. One possibility is that Tat protein itself is secreted by cel
Rates of shutdown of HIV-1 into latency: roles of the LTR and tat/rev/vpu gene region.: Virology. 1996 Nov 15;225(2):377-86. Unique Identifier : AIDSLINE GENBANK/D86069; Song SK; Li H; Cloyd MW; Department of Microbiology/Immunology, University of Texas; Medical Branch, Galveston 77555-1019, USA.; CEM T-cells chronically infected with most HIV-1 isolates gradually cease virus production over a 4-6 week period. This is due to slow shutdown of virus replication in the majority of the cells, leading to latent infections. We identified one HIV-1 isolate (HIV213) which shut down into latency at a rate much slower th
Phylogenetic and epidemiologic analysis of the walleye dermal sarcoma virus.: Virology. 1996 Nov 15;225(2):406-12. Unique Identifier : AIDSLINE MED/97078803; Zhang Z; Du Tremblay D; Lang BF; Martineau D; Departement de Pathologie et Microbiologie, Faculte de; Medecine Veterinaire, Universite de Montreal,; Saint-Hyacinthe, Quebec, Canada.; Walleye dermal sarcoma virus (WDSV) is a newly described retrovirus that is etiologically associated with a multifocal skin tumor of a fish common in North America, the walleye. Tumor prevalence ranges from 27% of adult walleyes in a densely populated lake, Oneida Lake, New York, to 1% in less populated waters. Phylog
Productive and persistent infection of human thymic epithelial cells in vitro with HIV-1.: Virology. 1996 Nov 15;225(2):413-8. Unique Identifier : AIDSLINE MED/97078804; Braun J; Valentin H; Nugeyre MT; Ohayon H; Gounon P; Barre-Sinoussi F; Unite de Biologie des Retrovirus, Institut Pasteur, Paris,; France.; Infection with HIV-1 results in a disruption of the thymic microenvironment and the presence of HIV-1 in thymic epithelial cells has been demonstrated in vivo. In the present study, we examined the susceptibility of a highly enriched culture of thymic epithelial cells (TEC) to infection in vitro by HIV-1 laboratory st
Identification of HTLV-1-specific CTL directed against synthetic and naturally processed peptides in HLA-B*3501 transgenic mice.: Virology. 1996 Dec 1;226(1):102-12. Unique Identifier : AIDSLINE MED/97096303; Schonbach C; Nokihara K; Bangham CR; Kariyone A; Karaki S; Shida H; Takatsu K; Egawa K; Wiesmuller KH; Takiguchi M; Department of Tumor Biology, University of Tokyo, Japan.; Previous studies of CTL responses to influenza peptides in HLA single transgenic mice resulted in the identification of at most one immunodominant epitope. Since HLA-B*3501 is known to present multiple HIV-1-specific T cell epitopes we tested the cellular immune response of HLA-B*3501 transgenic mice to synthetic HTLV
Definition of the RRE binding and activation domains of the caprine arthritis encephalitis virus Rev protein.: Virology. 1996 Dec 1;226(1):113-21. Unique Identifier : AIDSLINE MED/97096304; Schoborg RV; Clements JE; Quillen College of Medicine, East Tennessee State University,; Johnson City 37614, USA.; Caprine arthritis encephalitis virus (CAEV) is a lentivirus which is closely related by nucleotide sequence and biological properties to visna virus and is more distantly related to the human AIDS virus, HIV-1. Previous studies indicated that the CAEV Rev protein (Rev-C) functions as a trans-activator of mRNA cytoplas
Inducible gene expression of the human immunodeficiency virus LTR in a replication-incompetent herpes simplex virus vector.: Virology. 1996 Dec 1;226(1):127-31. Unique Identifier : AIDSLINE MED/97096306; Warden MP; Weir JP; Laboratory of DNA Viruses, Food and Drug Administration,; Bethesda, Maryland 20892, USA.; Although replication-incompetent herpes simplex virus (HSV) vectors have the capability to express foreign genes, successful development of these vectors for gene delivery would require that expression of the foreign gene be regulated. To investigate the feasibility of obtaining inducible expression of a foreign gene
Complement-activating antibodies in sera from infected individuals and vaccinated volunteers that target human immunodeficiency virus type 1 to complement receptor type 1 (CR1, CD35).: Virology. 1996 Dec 1;226(1):13-21. Unique Identifier : AIDSLINE MED/97096294; Zhou J; Montefiori DC; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710, USA.; Complement receptor type 1 (CR1) plays a central role in clearing immune complexes from the circulation and probably contributes to the retention of immune complexes on the surface of follicular dendritic cells. Virus-specific, complement-activating antibodies can target human immunodeficiency virus type 1 (HIV-1) to
Characterization of a novel baboon virus closely resembling human T-cell leukemia virus.: Virology. 1996 Dec 1;226(1):57-65. Unique Identifier : AIDSLINE GENBANK/U03160; Vincent MJ; Novembre FJ; Yamshchikov VF; McClure HM; Compans RW; Department of Microbiology and Immunology, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.; We report the isolation of a virus from a baboon imported from Kenya and the analysis of the nucleotide sequence of the env gene. Comparison of the complete nucleotide sequence of the env gene of different HTLV-1 strains and the baboon T-cell leukemia virus (designated BTLV) indicat
[Rehabilitation of deafness in the elderly: multidisciplinary intervention in experimental university center]: Acta Otorhinolaryngol Ital. 1996 Feb;16(1 Suppl 52):3-16. Unique Identifier : AIDSLINE MED/97090823; Menozzi Tucci F; Cantoni L; Riva L; Bergamaschi M; Capuzzi P; Fiorini T; Cardini P; Allegra P; Fontanella A; Galetti G; Dipartimento di Scienze Neuropsicosensoriali, Ospedale Maggiore,; Milano.; The loss of hearing abilities can be seen as a complex event because psychological discomfort and relational inhibitions interact and lead to behaviours and attitudes which are insidious and dangerous for the quality of life of the patient. The complexity of the psychological-organic inconvenience, such as impairement
Delinquency and family problems in incarcerated adolescents with and without a history of inhalant use.: Addict Behav. 1996 Jul-Aug;21(4):537-42. Unique Identifier : AIDSLINE MED/96427597; McGarvey EL; Canterbury RJ; Waite D; Institute for Substance Abuse Studies, Blue Ridge Hospital,; University of Virginia, Charlottesville 22901, USA.; In this retrospective study of incarcerated adolescents, inhalants were used by significantly more nonminority than minority youth. Among both minority and nonminority groups, family problems and delinquent behaviors were higher among those youth with a history of inhalant use than those who reported no use. Family pr
Cellular proteases involved in the pathogenicity of enveloped animal viruses, human immunodeficiency virus, influenza virus A and Sendai virus.: Adv Enzyme Regul. 1996;36:325-47. Unique Identifier : AIDSLINE MED/97023394; Kido H; Niwa Y; Beppu Y; Towatari T; Division of Enzyme Chemistry, University of Tokushima, Japan.; In enveloped viruses, post-translational proteolytic activation is a critical step for the fusion activity and thus for the infectivity of the virus. In addition to the membrane receptors for the viruses, proteolytic activation is indispensable for effective virus spread in the infected host and it is a prime determin
[T lymphocyte subsets in aqueous humor from patients with uveitis]: Nippon Ganka Gakkai Zasshi. 1996 Nov;100(11):899-904. Unique Identifier : AIDSLINE MED/97112189; Ohta K; Department of Ophthalmology, Shinshu University School of; Medicine, Nagano-ken, Japan.; We studied T lymphocyte subsets in the aqueous humor (AH) and peripheral blood (PB) from patients with active uveitis using three-color flow cytometry. We assessed the number of T lymphocyte subsets that stained with fluorescence-conjugated anti-CD3, CD4, CD8, CD29, CD45RA, CD45RO, and HLA (human leukocyte antigen)-DR
Encephalitozoon (Septata) intestinalis: cytologic, histologic, and electron microscopic features of a systemic intestinal pathogen.: Am J Clin Pathol. 1996 Nov;106(5):606-14. Unique Identifier : AIDSLINE MED/97083512; Chu P; West AB; Department of Pathology, Yale University, New Haven, Connecticut,; USA.; Encephalitozoon (Septata) intestinalis affects AIDS patients with CD4 counts
Cytomegalovirus antigenemia in acquired immunodeficiency syndrome patients with untreated cytomegalovirus retinitis.: Am J Ophthalmol. 1996 Dec;122(6):847-52. Unique Identifier : AIDSLINE MED/97115238; Pannuti CS; Kallas EG; Muccioli C; Roland RK; Ferreira EC; Bueno SM; Do Canto CL; Villas Boas LS; Belfort Junior R; Division of Infectious Diseases, Hospital do Servidor Publico; Estadual de Sao Paulo, Brazil. cpannuti@usp.br; PURPOSE: To determine the frequency of cytomegalovirus ( CMV ) viremia in patients with acquired immunodeficiency syndrome (AIDS) and untreated CMV retinitis using conventional cell culture isolation and the sensitive CMV antig
Progressive outer retinal necrosis after bone marrow transplantation.: Am J Ophthalmol. 1996 Dec;122(6):892-5. Unique Identifier : AIDSLINE MED/97115248; Lewis JM; Nagae Y; Tano Y; Department of Ophthalmology, Osaka University Medical School.; jlewis@med.wayne.edu; PURPOSE: To describe a case of progressive outer retinal necrosis in a human immunodeficiency virus-negative immunosuppressed patient undergoing treatment for graft-versus-host disease after bone marrow transplantation. METHOD: Onset, course, and outcome of the patient s eye disease were analyzed. RESULTS: Findings an
Chiasmal infarction and sudden blindness caused by mucormycosis in AIDS and diabetes mellitus.: Am J Ophthalmol. 1996 Dec;122(6):895-6. Unique Identifier : AIDSLINE MED/97115249; Lee BL; Holland GN; Glasgow BJ; UCLA Ocular Inflammatory Disease Center, USA.; PURPOSE: To report rapidly progressive rhino-orbitocerebral mucormycosis in a 47-year-old woman with both diabetes mellitus and the acquired immunodeficiency syndrome (AIDS). METHOD: Case report including postmortem examination of the eyes, orbit, and brain of a patient with rhino-orbitocerebral mucormycosis, diabetes
The use of glucan as immunostimulant in the treatment of paracoccidioidomycosis.: Am J Trop Med Hyg. 1996 Nov;55(5):496-503. Unique Identifier : AIDSLINE MED/97095956; Meira DA; Pereira PC; Marcondes-Machado J; Mendes RP; Barraviera B; Pellegrino Junior J; Rezkallah-Iwasso MT; Peracoli MT; Castilho LM; Thomazini I; Da Silva CL; Foss NT; Curi PR; Department of Tropical Diseases and Diagnosis by Image,; Hemocenter of Botucatu, State University of Sao Paulo, Brazil.; A group of 10 patients, nine of them seriously infected with Paracoccidioides brasiliensis (G1), received glucan (beta-1,3 polyglucose) as an immunostimulant intravenously once a week for one month, followed by monthly doses (10 mg) over an 11-month period, together with a specific anti-fungal agent as an immunostimul
[Cutaneous and neurologic vasculitis disclosing EBV-selective immunodeficiency]: Ann Dermatol Venereol. 1996;123(6-7):387-92. Unique Identifier : AIDSLINE MED/97118179; Grosieux C; Amoric JC; Mechinaud F; Moreau A; Mussini JM; Fesneau H; Dreno B; Bureau B; Stalder JF; Litoux P; CHU de Nantes, Hotel-Dieu.; INTRODUCTION: Purtilo s syndrome or X-linked lymphoproliferative syndrome (XLP) is a rare genetic disorder affecting boys who have a selective immunodeficit towards Epstein Barr Virus (EBV) and who develop extremely severe forms of EBV infection, of which there are four major types: severe or fatal infectious mononucl
[A case for diagnosis: Neisseria gonorrhoeae conjunctivitis]: Ann Dermatol Venereol. 1996;123(6-7):403-4. Unique Identifier : AIDSLINE MED/97118184; Pechere M; Rohner P; Harms M
Endocarditis in an urban hospital in the 1990s.: Arch Intern Med. 1996 Nov 25;156(21):2454-8. Unique Identifier : AIDSLINE MED/97100171; Siddiq S; Missri J; Silverman DI; Cardiology Division, John Dempsey Hospital, University of; Connecticut School of Medicine, Farmington, USA.; OBJECTIVES: To analyze the clinical characteristics and outcome of 159 consecutive patients with endocarditis who presented to an inner-city hospital from 1990 onward and to elucidate the most current problems and advances in the management of endocarditis. METHODS: One hundred eighty-two consecutive cases (in 159 pat
Antibodies to Bartonella species in inner-city intravenous drug users in Baltimore, Md.: Arch Intern Med. 1996 Nov 25;156(21):2491-5. Unique Identifier : AIDSLINE MED/97100175; Comer JA; Flynn C; Regnery RL; Vlahov D; Childs JE; Viral and Rickettsial Zoonoses Branch, Centers for Disease; Control and Prevention, Atlanta, Ga, USA.; BACKGROUND: Bartonella quintana has recently been associated with homeless alcoholic men. Both B quintana and Bartonella henselae have been shown to be opportunistic pathogens of people with acquired immunodeficiency syndrome. The reservoirs and modes of transmission of these infections are incompletely known. OBJECTI
Megestrol for appetite stimulation and as a progestin in hormone replacement therapy [letter]: Arch Intern Med. 1996 Nov 25;156(21):2498. Unique Identifier : AIDSLINE MED/97100177; Rance LB; Tseng AL; Bayoumi A
HIV in the mentally ill.: Aust N Z J Psychiatry. 1996 Apr;30(2):184-94. Unique Identifier : AIDSLINE MED/96407192; Checkley GE; Thompson SC; Crofts N; Mijch AM; Judd FK; Epidemiology and Social Research Unit, Macfarlane Burnet Centre; for Medical Research, Fairfield, Victoria, Australia.; OBJECTIVE: To review the published literature in relation to prevalence of HIV infection and risk behaviours for HIV among the mentally ill to assist in the development of appropriate strategies for public health policy, surveillance and clinical management of HIV and HIV risk in these groups. METHOD: A search of publ
Growth hormone and IGF-I therapy in the hypercatabolic patient.: Baillieres Clin Endocrinol Metab. 1996 Jul;10(3):447-63. Unique Identifier : AIDSLINE MED/97006156; Wolf SE; Barrow RE; Herndon DN; Shiners Burns Institute, Galveston Unit, TX 77550, USA.; The use of exogenous GH to increase its circulating concentration, may benefit critically ill patients by increasing their nitrogen retention and promoting the wound healing process. GH also changes protein production in wounds, causes higher levels of insulin and changes substrate utilization. Its effects are anaboli
Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues.: Biochem Biophys Res Commun. 1996 Nov 12;228(2):285-92. Unique Identifier : AIDSLINE GENBANK/Y08162; Owman C; Blay P; Nilsson C; Lolait SJ; Department of Physiology and Neuroscience, Wallenberg; Neuroscience Center, University of Lund, Sweden.; christer.owman@mphy.lu.se; Using PCR with degenerate primers and screening of a human B-cell lymphoblast cDNA library, a full-length cDNA encoding a 375-amino-acid protein was isolated. It contains seven regions of hydrophobic amino acids probably representing membrane-spanning domains of a novel heptahelix receptor, tentatively named CMKRL2. I
Hairpin antisense oligonucleotides containing 2'-methoxynucleosides with base-pairing in the stem region at the 3'-end: penetration, localization, and Anti-HIV activity.: Biochem Biophys Res Commun. 1996 Nov 12;228(2):623-31. Unique Identifier : AIDSLINE MED/97079228; Kuwasaki T; Hosono K; Takai K; Ushijima K; Nakashima H; Saito T; Yamamoto N; Takaku H; Department of Industrial Chemistry, Chiba Institute of; Technology, Narashino, Japan.; Hairpin antisense oligodeoxyribonucleotides containing 2 -methoxynucleosides were more active in the micromolar concentration range than linear and DNA hairpin phosphorothioate oligonucleotides with the same sequence. Furthermore, the abilities of hairpin antisense and random hairpin phosphorothioate oligonucleotides
Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides.: Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. Unique Identifier : AIDSLINE MED/97079229; Derua R; Gustafson KR; Pannell LK; Laboratory of Analytical Chemistry, NIDDK, NIH, Bethesda,; Maryland 20892-0805, USA.; Circulin A and B are members of a family of macrocyclic peptides, originally isolated from the tropical tree Chassalia parvifolia, that have been shown to display anti-HIV activity. Complete structural elucidation of these highly constrained peptides was difficult due to their cyclic amide backbone and the presence of
Targeting of the Sp1 binding sites of HIV-1 long terminal repeat with chromomycin. Disruption of nuclear factor.DNA complexes and inhibition of in vitro transcription.: Biochem Pharmacol. 1996 Nov 22;52(10):1489-98. Unique Identifier : AIDSLINE MED/97091796; Bianchi N; Passadore M; Rutigliano C; Feriotto G; Mischiati C; Gambari R; Biotechnology Centre, Ferrara University, Italy.; Sequence selectivity of DNA-binding drugs has recently been reported in a number of studies employing footprinting and gel retardation approaches. In this paper, we studied the biochemical effects of the sequence-selective binding of chromomycin to the long terminal repeat of the human immunodeficiency type I virus. D
[New phospholipids--inhibitors of human immunodeficiency virus reproduction. Synthesis and antiviral activity]: Bioorg Khim. 1996 Jun;22(6):451-7. Unique Identifier : AIDSLINE MED/97041066; Vodovozova EL; Pavlova IuB; Polushkina MA; Rzhaninova AA; Garaev MM; Molotkovskii IuG; Several novel phosphatidic acid derivatives of 3 -azido-3 -deoxythymidine and 2 ,3 -dideoxyinosine were synthesized, which contained dialkylphosphatidyl, dialkylthiophosphatidyl moieties, as well as diacylphosphatidyl moiety with either 14,14,14-trifluoro-12-oxatetradecanoyl or natural acyl residues inherent in egg yo
Serum vitamin A, vitamin E, and beta-carotene levels in preeclamptic women in northern nigeria.: Am J Perinatol. 1996 Jul;13(5):287-91. Unique Identifier : AIDSLINE MED/97017346; Ziari SA; Mireles VL; Cantu CG; Cervantes M 3rd; Idrisa A; Bobsom D; Tsin AT; Glew RH; Division of Life Sciences, University of Texas at San Antonio,; USA.; We compared the serum levels of beta-carotene, vitamin A (retinol), and vitamin E (alpha-tocopherol) in healthy pregnant women and their counterparts who exhibited the signs and symptoms of preeclampsia or eclampsia, including: systolic blood pressure greater than 160 mm Hg, edema, and proteinuria. The study was condu
Otolaryngologic disease progression in children with human immunodeficiency virus infection.: Arch Otolaryngol Head Neck Surg. 1996 Dec;122(12):1360-3. Unique Identifier : AIDSLINE MED/97115349; Chen AY; Ohlms LA; Stewart MG; Kline MW; Bobby R. Alford Department of Otorhinolaryngology and; Communicative Sciences, Baylor College of Medicine, Houston, Tex,; USA.; OBJECTIVES: To evaluate the prevalence of otolaryngologic disease in children born to mothers infected with human immunodeficiency virus (HIV) and to assess the correlation between HIV disease severity and the incidence density of recurrent otitis media (OM) and sinusitis based on the revised 1994 Centers for Disease
Application of RAPD and restriction enzyme analysis to the study of oral carriage of Candida albicans.: Lett Appl Microbiol. 1996 Feb;22(2):125-8. Unique Identifier : AIDSLINE MED/97090464; Howell SA; Anthony RM; Power E; Department of Microbial Diseases, St John's Institute of; Dermatology, London, UK.; The genetic similarity of nineteen isolates of Candida albicans from four patients were compared by restriction fragment length polymorphism (RFLP) using EcoRI or HinfI, which both detected five types, and by random amplification of polymorphic DNA (RAPD), which detected three types. Phenotypically unusual isolates al
Priming of neutrophil and monocyte activation in human immunodeficiency virus infection. Comparison of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and interferon-gamma.: APMIS. 1996 Sep;104(9):640-6. Unique Identifier : AIDSLINE MED/97128018; Meyer CN; Nielsen H; Department of Infectious Diseases, National University Hospital; (Rigshospitalet), Copenhagen, Denmark.; Activation of human blood neutrophils and monocytes for enhanced release of toxic oxygen radicals may take place after priming with several cytokines including hematopoietic growth factors. The potential impact of human immunodeficiency virus (HIV) on this response and the relative potency of various cytokines remains
Co-infection with HIV-1/HTLV-II and the risk of progression to AIDS and death. The Oslo HIV Cohort Study Group.: APMIS. 1996 Sep;104(9):666-72. Unique Identifier : AIDSLINE MED/97128021; Eskild A; Samdal HH; Heger B; Department of Epidemiology, National Institute of Public Health,; Oslo, Norway.; Human T-cell lymphotropic virus (HTLV) types I and II were the first discovered human retroviruses. While HTLV-I has been clearly associated with disease, the health implications of HTLV-II infection are still unsettled. A prospective epidemiological study of 409 HIV-infected subjects of different transmission categor
Soft tissue sarcomas in HIV-infected adult patients.: Eur J Cancer. 1996 Sep;32A(10):1812-4. Unique Identifier : AIDSLINE MED/97105656; Fizazi K; Feuillard J; Le Cesne A; Terrier P; Raphael M; Pouillart P; Tursz T; Department of Medical Oncology, Institut Gustave-Roussy,; Villejuif, France.; Clinical and biological features of three HIV-infected adults with soft tissue sarcoma are reported. Epstein-Barr Virus (EBV) detection was negative using in situ hybridisation, PCR analysis and Southern blot analysis in the two cases for which tumour samples were available, contrary to all previously reported paediat
Computer assisted learning (CAL) of oral manifestations of HIV disease.: Br Dent J. 1996 Sep 7;181(5):173-7. Unique Identifier : AIDSLINE MED/97007150; Porter SR; Telford A; Chandler K; Furber S; Williams J; Price S; Scully C; Triantos D; Bain L; Department of Oral Medicine, Eastman Dental Institute, London.; General dental practitioners (GDPs) in the UK may wish additional education on relevant aspects of human immunodeficiency virus (HIV) disease. The aim of the present study was to develop and assess a computer assisted learning package on the oral manifestations of HIV disease of relevance to GDPs. A package was develo
Rheumatic aspects of acquired immunodeficiency syndrome.: Curr Opin Rheumatol. 1996 Jul;8(4):346-53. Unique Identifier : AIDSLINE MED/97017970; Itescu S; Department of Surgary, Columbia University College of Physicians; and Surgeons, New York, NY 10032, USA.; Infection with HIV-1 continues to provide important insights into autoimmunity and rheumatic diseases. Studies on the mechanisms of B cell hyperreactivity in HIV-infected persons suggest a primary role for B cell complement receptor engagement by circulating immune complexes in the production of autoantibodies. Deline
Leishmania infection occurring in herpes zoster lesions in an HIV positive patient [letter]: Br J Dermatol. 1996 Dec;135(6):1005-6. Unique Identifier : AIDSLINE MED/97132276; Del Giudice P
Pityriasis rubra pilaris and human immunodeficiency virus infection--type 6 pityriasis rubra pilaris?: Br J Dermatol. 1996 Dec;135(6):1008-9. Unique Identifier : AIDSLINE MED/97132279; Misery I; Faure M; Claidy A
The role of circulating food antigen-specific lymphocytes in food allergic children with atopic dermatitis.: Br J Dermatol. 1996 Dec;135(6):935-41. Unique Identifier : AIDSLINE MED/97132259; Reekers R; Beyer K; Niggemann B; Wahn U; Freihorst J; Kapp A; Werfel T; Department of Dermatology, Hannover Medical School, Germany.; In this study we evaluated antigen-specific in vitro responses of peripheral blood lymphocytes to lipopolysaccharide (LPS)-depleted food allergens in children who reacted to food challenge (cow s milk or hen s egg) with a deterioration of their atopic dermatitis (AD). Some of the children showed immediate symptoms (ur
Bacillary angiomatosis in an HIV seronegative patient on systemic steroid therapy.: Br J Dermatol. 1996 Dec;135(6):982-7. Unique Identifier : AIDSLINE MED/97132268; Schwartz RA; Gallardo MA; Kapila R; Gascon P; Herscu J; Siegel I; Lambert WC; UMD-New Jersey Medical School, Newark 07103-2714, USA.; Bacillary angiomatosis is an unusual systemic vascular proliferation seen predominantly in patients with the acquired immunodeficiency syndrome. These vascular lesions are due to infection with a Bartonella species, most commonly B. henselae, but sometimes B. quintana. It is treatable and often curable, but without th
Localization of HIV-1 in human thymic implant in SCID-hu mice after intravenous inoculation.: Int J Exp Pathol. 1996 Oct;77(5):201-6. Unique Identifier : AIDSLINE MED/97131914; Ogura A; Noguchi Y; Yamamoto Y; Shibata S; Asano T; Okamoto Y; Honda M; Department of Veterinary Science, National Institute of Health,; Tokyo, Japan.; Human immunodeficiency virus type 1 (HIV-1) was immunohistochemically and ultrastructurally localized in human thymus implants in SCID-hu mice 3 weeks after intravenous (i.v.) inoculation of the virus. A viral antigen (gp120) was predominantly distributed in and around the epithelial cells in Hassall s corpuscles as d
V beta 6-bearing T cells are involved in resistance to Trypanosoma cruzi infection in XID mice.: Int Immunol. 1996 Aug;8(8):1213-9. Unique Identifier : AIDSLINE MED/97076382; Cordeiro da Silva A; Lima EC; Vicentelli MH; Minoprio P; Unite d'Immunoparasitologie, CNRS, URA 1960, Departement; d'Immunologie, Institut Pasteur, Paris, France.; BALB.xid mice, carrying an X-linked mutation leading to the absence of CD5+ B cells, are highly resistant to Trypanosoma cruzi infection. These mice clear blood parasites in the acute phase of infection and do not develop the inflammatory infiltration characteristically observed in the chronic phase of susceptible str
IL-12 promotes cellular but not humoral type II collagen-specific Th 1-type responses in C57BL/6 and B10.Q mice and fails to induce arthritis.: Int Immunol. 1996 Aug;8(8):1221-7. Unique Identifier : AIDSLINE MED/97076383; Szeliga J; Hess H; Rude E; Schmitt E; Germann T; Institut fur Immunologie, Mainz, Germany.; DBA/1 (H-2q) and C57BL/6 (H-2b) mice develop an intermediate immune responses when immunized with chicken type II collagen (CII) emulsified with incomplete Freund s adjuvant (IFA). Only a few animals develop a mild form of arthritis. As reported before and confirmed herein, administration of IL-12 to DBA/1 mice immuni
TCR- and IL-1-mediated co-stimulation reveals an IL-4-independent way of Th2 cell proliferation.: Int Immunol. 1996 Aug;8(8):1257-63. Unique Identifier : AIDSLINE MED/97076387; Huber M; Rutherford A; Meister W; Weiss A; Rollinghoff M; Lohoff M; Institute of Clinical Microbiology and Immunology, University of; Erlangen-Nurnberg, Germany.; Previously, it has been shown that Th1 cells, when triggered solely via their TCR, are blocked from proliferation in response to IL-2 . Herein, we describe a similar characteristic for Th2 cells in that immobilized mAb directed to the TCR blocked proliferation of Th2 ce
Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals.: Int Immunol. 1996 Aug;8(8):1311-7. Unique Identifier : AIDSLINE MED/97076392; Katsikis PD; Garcia-Ojeda ME; Wunderlich ES; Smith CA; Yagita H; Okumura K; Kayagaki N; Alderson M; Herzenberg LA; Herzenberg LA; Department of Genetics, Beckman Center B007, Stanford University; School of Medicine, CA 94305, USA.; T cell apoptosis has been proposed as an important contributor to the functional defects and depletion of T cells in HIV-infected individuals. However, the mechanisms involved in this apoptosis have not been elucidated. We recently showed that peripheral blood T cells from HIV-infected individuals are especially susce
Progressive decrease in VH3 gene family expression in plasma cells of HIV-infected patients.: Int Immunol. 1996 Aug;8(8):1329-33. Unique Identifier : AIDSLINE MED/97076394; David D; Demaison C; Bani L; Theze J; Department d'Immunologie, Institut Pasteur, Paris, France.; We have analysed the expression of VH gene families in total peripheral plasma cells of mu and gamma isotypes from a group of HIV-infected patients. CD19- and CD20- cells were separated from B lymphocytes, and anchored RT-PCR products were hybridized with specific VH gene family probes and with a consensus JH region p
Melanoma specific Th1 cytotoxic T lymphocyte lines in Vogt-Koyanagi-Harada disease [see comments]: Br J Ophthalmol. 1996 Nov;80(11):1002-8. Unique Identifier : AIDSLINE MED/97131078; Norose K; Yano A; Department of Ophthalmology, Shinshu University School of; Medicine, Matsumoto, Japan.; AIMS/BACKGROUND: To determine the functional properties and cytokine production profiles of melanoma specific cytotoxic T lymphocytes (CTLs) induced from peripheral blood leucocytes of two patients with Vogt-Koyanagi-Harada disease (VKH). METHODS: Melanoma specific CTL lines were established by long term coculture wit
Aetiology of uveitis in Sierra Leone, west Africa.: Br J Ophthalmol. 1996 Nov;80(11):956-61. Unique Identifier : AIDSLINE MED/97131069; Ronday MJ; Stilma JS; Barbe RF; McElroy WJ; Luyendijk L; Kolk AH; Bakker M; Kijlstra A; Rothova A; Netherlands Opthalmic Research Institute, Amsterdam, The; Netherlands.; BACKGROUND: In 1992, non-onchocercal uveitis caused 9% of blindness, 8% of visual impairment, and 11% of uniocular blindness among patients visiting an eye hospital in Sierra Leone , west Africa. The aim of this study was to determine the aetiology of uveitis in this population
Association of progressive outer retinal necrosis and varicella zoster encephalitis in a patient with AIDS.: Br J Ophthalmol. 1996 Nov;80(11):982-5. Unique Identifier : AIDSLINE MED/97131074; van den Horn GJ; Meenken C; Troost D; Department of Ophthalmology, Academic Medical Center, University; of Amsterdam, The Netherlands.; BACKGROUND: A patient with AIDS who developed the clinical picture of bilateral progressive outer retinal necrosis (PORN) in combination with varicella zoster encephalitis is described. The picture developed more than 2 years after an episode of ophthalmic zoster infection, and following intermittent exposure to oral
HTLV-I associated uveitis revisited: characteristic grey-white, granular deposits on retinal vessels.: Br J Ophthalmol. 1996 Aug;80(8):719-22. Unique Identifier : AIDSLINE MED/97106968; Nakao K; Ohba N; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.; AIMS: To elucidate whether there exists any clinical sign characteristic of HTLV-I associated uveitis. METHODS: Fifty five patients with HTLV-I associated uveitis were reviewed. These cases had serum antibodies to HTLV-I, and any other uveitis entities were carefully excluded by means of clinical and laboratory studie
Retinal blood flow indices in patients infected with human immunodeficiency virus.: Br J Ophthalmol. 1996 Aug;80(8):723-7. Unique Identifier : AIDSLINE MED/97106969; Yung CW; Harris A; Massicotte S; Chioran G; Krombach G; Danis R; Wolf S; Department of Ophthalmology, Indiana University School of; Medicine, Indianapolis, USA.; AIMS/BACKGROUND: Abnormal blood flow dynamics are believed to contribute to the development of retinal microvascular disease in patients infected with human immunodeficiency virus (HIV). In this study, the scanning laser ophthalmoscope (SLO) was used, combined with fluorescein angiography, to measure retinal blood flo
'Creeping' cytomegalovirus retinitis in AIDS [letter]: Br J Ophthalmol. 1996 Aug;80(8):771-2. Unique Identifier : AIDSLINE MED/97106981; Dhillon B; Cacciatori M; Ling C
Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer.: Biochemistry. 1996 Dec 3;35(48):15397-410. Unique Identifier : AIDSLINE MED/97110331; Filipowsky ME; Kopka ML; Brazil-Zison M; Lown JW; Dickerson RE; Molecular Biology Institute, University of California at Los; Angeles 90095, USA.; Five classic DNA minor groove-binding drugs and a series of bis-linked lexitropsins based on netropsin and distamycin have been screened for their effectiveness in inhibiting transcription by HIV-1 reverse transcriptase (RT) on a poly(rA).oligo(dT) template-primer (TP). The two most effective drugs, 3,5 m-pyridyl-link
Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance.: Biochim Biophys Acta. 1996 Nov 14;1298(1):37-44. Unique Identifier : AIDSLINE MED/97104329; Tamamura H; Ishihara T; Otaka A; Murakami T; Ibuka T; Waki M; Matsumoto A; Yamamoto N; Fujii N; Faculty of Pharmaceutical Sciences, Kyoto University, Japan.; We have previously found that T22 ([Tyr5, 12, Lys7]-polyphemusin II) exhibits strong anti-human immunodeficiency virus (HIV) activity comparable to that of 3 -azido-2 , 3 -dideoxythymidine ( AZT ). The inhibition mechanism of T22 on HIV-replication has
Lymphocyte subset counts during the course of community-acquired pneumonia: evolution according to age, human immunodeficiency virus status, and etiologic microorganisms.: Clin Infect Dis. 1996 Jun;22(6):1096-8. Unique Identifier : AIDSLINE MED/96377944; Fantin B; Joly V; Elbim C; Golmard JL; Gougerot-Pocidalo MA; Yeni P; Carbon C; Service de Medecine Interne, Hopital Bichat-Claude Bernard,; Paris, France.; We investigated the evolution of lymphocyte subsets in blood samples from 94 consecutive patients with community-acquired pneumonia; these samples were obtained 72 hours after hospitalization and at follow-up, when the patients were considered to be cured. Acute-phase lymphocyte counts, as compared with follow-up coun
Polyarthritis caused by Leishmania in a patient with AIDS.: Clin Infect Dis. 1996 Jun;22(6):1113-4. Unique Identifier : AIDSLINE MED/96377953; Perello-Roso A; Lopez-Aldeguer J; Garcia-Gasco P; Blanes M; Department of Internal Medicine, Hospital Universitari La Fe,; Valencia, Spain.
The role of human herpesvirus 8 and Epstein-Barr virus in the pathogenesis of giant lymph node hyperplasia (Castleman's disease).: Clin Infect Dis. 1996 Jun;22(6):1120-1. Unique Identifier : AIDSLINE MED/96377958; Corbellino M; Poirel L; Aubin JT; Paulli M; Magrini U; Bestetti G; Galli M; Parravicini C; Clinic of Infectious Diseases, State University, Milan, Italy.
Dementia and pancytopenia in a patient who died of AIDS within one year of primary human immunodeficiency virus infection.: Clin Infect Dis. 1996 Jun;22(6):1121-2. Unique Identifier : AIDSLINE MED/96377959; Holland DJ; Dwyer DE; Saksena NK; Naif H; Packham DR; Downie J; Cunningham AL; Department of Virology, Westmead Hospital, New South Wales,; Australia.
Ramsay Hunt syndrome in a patient infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1996 Jun;22(6):1128-9. Unique Identifier : AIDSLINE MED/96377964; Johnson KB; Blazes DL; Keith M; Decker CF; Ohl CA
Treatment of human immunodeficiency virus-related thrombocytopenia with intravenous anti-rhesus D immunoglobulin [letter]: Clin Infect Dis. 1996 Jun;22(6):1129-30. Unique Identifier : AIDSLINE MED/96377965; Zunich KM; Katz M; Woloski M; Bussel J
Cerebral lesions in two patients with AIDS: the possible role of Mycobacterium kansasii [letter]: Clin Infect Dis. 1996 Jun;22(6):1130-1. Unique Identifier : AIDSLINE MED/96377966; Monno L; Carbonara S; Costa D; Appice A; Rollo M; Coppola S; Angarano G
Dapsone therapy for thrombocytopenia in patients infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1996 Jun;22(6):1131-2. Unique Identifier : AIDSLINE MED/96377967; Durand JM; Lefevre P; Cretel E; Kaplanski G; Soubeyrand J
Paracoccidioidomycosis and AIDS [letter]: Clin Infect Dis. 1996 Jun;22(6):1132-3. Unique Identifier : AIDSLINE MED/96377968; Nishioka S de A
Nocardiosis.: Clin Infect Dis. 1996 Jun;22(6):891-903; quiz 904-5. Unique Identifier : AIDSLINE MED/96377910; Lerner PI; Mt. Sinai Medical Center, School of Medicine, Case Western; Reserve University, Division of Infectious Diseases, Cleveland,; Ohio 44106-4198, USA.
Neuroimaging findings in patients with AIDS.: Clin Infect Dis. 1996 Jun;22(6):906-19. Unique Identifier : AIDSLINE MED/96377911; Walot I; Miller BL; Chang L; Mehringer CM; Department of Radiology, Harbor-UCLA Medical Center, Torrance; 90509, USA.; An increasing number of patients are presenting with central nervous system complications of human immunodeficiency virus infection. New imaging technologies such as magnetic resonance imaging, magnetic resonance proton spectroscopy, single-photon emission computed tomography, and positron emission tomography are play
Herpes simplex esophagitis in patients with AIDS: report of 34 cases. The Cooperative Study Group on Herpetic Esophagitis in HIV Infection.: Clin Infect Dis. 1996 Jun;22(6):926-31. Unique Identifier : AIDSLINE MED/96377913; Genereau T; Lortholary O; Bouchaud O; Lacassin F; Vinceneux P; De Truchis P; Jaccard A; Meynard JL; Verdon R; Sereni D; Marche C; Coulaud JP; Guillevin L; Service de Medecine Interne, Hopital Avicenne, Universite; Paris-Nord, Bobigny, France.; Herpetic esophagitis (HE) associated with human immunodeficiency virus (HIV) is a rare condition mainly reported as isolated cases. We thus decided to study this association and analyze the possible predisposing factors, clinical and endoscopic presentations, and clinical response to treatment. Thirty-four HIV-1-infec
Photo quiz. Alveolar echinococcosis.: Clin Infect Dis. 1996 Jun;22(6):965, 1089. Unique Identifier : AIDSLINE MED/96377919; Soelder B; Allerberger F; Sailer M; Zaknun D; Feichtinger J; Seitz HM; Department of Pediatrics, University of Innsbruck, Austria.
Tuberculous meningitis in adults: review of 48 cases.: Clin Infect Dis. 1996 Jun;22(6):982-8. Unique Identifier : AIDSLINE MED/96377922; Verdon R; Chevret S; Laissy JP; Wolff M; Clinique de Reanimation des Maladies Infectieuses, Hopital; Bichat-Claude Bernard, Paris, France.; The cases of 48 adult patients with tuberculous meningitis who were admitted to intensive care unit (ICU) between 1982 and 1993 were reviewed. An underlying disease was present in 24 patients (50%), including 10 with human immunodeficiency virus infection. Forty-seven patients were referred to the ICU because of neuro
Species distribution in human immunodeficiency virus-related mycobacterial infections: implications for selection of initial treatment.: Clin Infect Dis. 1996 Jun;22(6):989-92. Unique Identifier : AIDSLINE MED/96377923; Montessori V; Phillips P; Montaner J; Haley L; Craib K; Bessuille E; Black W; AIDS Research Program, St. Paul's Hospital, Vancouver, British; Columbia, Canada.; Management of mycobacterial infection is species specific; however, treatment is prompted by positive smears or cultures, often several weeks before species identification. The objective of this study was to determine the species distribution of mycobacterial isolates from various body sites in patients infected with
[Efficiency of bone marrow aspirate for diagnosis of opportunistic infections in HIV infected patients]: An Med Interna. 1996 Aug;13(8):374-7. Unique Identifier : AIDSLINE MED/97090869; Supervia A; Knobel H; Perez-Vila E; Abella ME; Salvado M; Mellibovsky L; Diez A; Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital; del Mar, Barcelona.; AIDS is the first cause of opportunistic infections. The objective of the present study was the evaluation of the efficiency of bone marrow aspirate (BMA) for diagnosis of opportunistic infections in HIV infected patients with prolonged fever. Charts from 92 patients with BMA from 1992 to 1994 were reviewed. Diagnosis
[Long term survival in an HIV-immunosuppressed patient treated with foscarnet]: An Med Interna. 1996 Aug;13(8):387-9. Unique Identifier : AIDSLINE MED/97090871; Soriano V; Mas A; Bravo R; Moreno V; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; An HIV-infected woman with a CD4+ T-cell count below 100 x 10(6)/l survived for longer than 4 years of being diagnosed of AIDS, with acceptable health status (Karnofsky > 80%). Administration of foscarnet during two years, recommended as suppressive therapy for a previous cytomegalovir
[Ocular toxoplasmosis in human immunodeficiency virus infected patients without concurrent central nervous system infection. Report of two cases]: An Med Interna. 1996 Aug;13(8):390-2. Unique Identifier : AIDSLINE MED/97090872; Orti A; Roig P; Chipont E; Cuadrado JM; Porras G; Navarro V; Servicio de Medicina Interna, Hospital Universitario de San Juan.; Ocular toxoplasmosis is an uncommon complication of acquired immunodeficiency syndrome (AIDS), and it is generally described associated with central nervous system (CNS) lesions. We describe two cases of ocular toxoplasmosis in human immunodeficiency virus (HIV) infected patients, without concurrent CNS infection. Bot
[Disseminated nocardiosis associated with HIV infection (letter)]: An Med Interna. 1996 Aug;13(8):408-9. Unique Identifier : AIDSLINE MED/97090879; Llorca Garrigos R; Granda Martin MJ; Lopez Gonzalez-Cobos C; Segado Soriano A
Manipulation of the Th1/Th2 cell balance: an approach to treat human autoimmune diseases?: Autoimmunity. 1996;23(1):53-68. Unique Identifier : AIDSLINE MED/97025583; Adorini L; Guery JC; Trembleau S; Roche Milano Ricerche, Italy.; Differentiated T cells produce a restricted set of lymphokines, allowing their subdivision into two major subsets: Th1 and Th2 cells. This has lead to a new paradigm for immunoregulation based on the Th1/Th2 dichotomy. A strict compartmentalization of T cells into Th1 and Th2 is clearly an oversimplification: regulato
The role of alpha 4 integrin and intercellular adhesion molecule-1 (ICAM-1) in murine experimental autoimmune thyroiditis.: Autoimmunity. 1996;23(1):9-23. Unique Identifier : AIDSLINE MED/97025579; McMurray RW; Tang H; Braley-Mullen H; Department of Internal Medicine, University of Missouri, Columbia; 65212, USA.; Mouse-thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg induce a lymphocytic form of experimental autoimmune thyroiditis (EAT) whereas activation of the same cell population with MTg in the presence of anti-interleukin 2 receptor antibody (M7/20) induces a granulomatous form of EAT. The thyroid i
A semiparametric extension of the Mann-Whitney test for randomly truncated data.: Biometrics. 1996 Mar;52(1):10-20. Unique Identifier : AIDSLINE MED/97088675; Bilker WB; Wang MC; Department of Biostatistics and Epidemiology, University of; Pennsylvania, Philadelphia 19104-6021, USA.; In many applications, statistical data are frequently observed subject to a retrospective sampling criterion resulting in pure right-truncated data. In classical testing problems, the Mann-Whitney test is used for testing the equality of two distributions. A semiparametric extension of this test is developed for the c
Nonparametric survival estimation using prognostic longitudinal covariates.: Biometrics. 1996 Mar;52(1):137-51. Unique Identifier : AIDSLINE MED/97088681; Murray S; Tsiatis AA; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; One of the primary problems facing statisticians who work with survival data is the loss of information that occurs with right-censored data. This research considers trying to recover some of this endpoint information through the use of a prognostic covariate which is measured on each individual. We begin by defining
A competing risks analysis of presenting AIDS diagnoses trends.: Biometrics. 1996 Mar;52(1):211-25. Unique Identifier : AIDSLINE MED/97088685; Fusaro RE; Bacchetti P; Jewell NP; Division of Biostatistics and School of Optometry, University of; California, Berkeley 94720-7380, USA.; The proportions of gay men presenting with various AIDS diagnoses display temporal trends. In particular, the proportion of initial diagnoses reported as Kaposi s sarcoma (KS) has declined over time. Epidemiologists have hypothesized that (a) KS may require a cofactor, whose prevalence has declined over time, or (b) K
A jackknife estimator of variance for Cox regression for correlated survival data.: Biometrics. 1996 Mar;52(1):291-8. Unique Identifier : AIDSLINE MED/97088690; Lipsitz SR; Parzen M; Department of Biostatistics, Harvard School of Public Health and; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.; Studies in the health sciences often give rise to correlated survival data. Wei, Lin, and Weissfeld (1989, Journal of the American Statistical Association 84, 1065-1073) and Lee, Wei, and Amato (1992, in Survival Analysis: State of the Art) showed that, if the marginal distributions of the correlated survival times fo
Is Kaposi sarcoma caused by new herpesvirus? [letter]: Biomed Pharmacother. 1996;50(6-7):318-9. Unique Identifier : AIDSLINE MED/97110725; Haverkos HW
Cell-mediated immunity in breast cancer patients.: Biomed Pharmacother. 1996;50(8):337-43. Unique Identifier : AIDSLINE MED/97110701; Nicolini A; Ferrari P; Spinelli R; Carpi A; Sagripanti A; Ambrogi F; Institute of Clinical Medicine University of Pisa, Italy.; In clinical practice, reports have been made on immunosuppression after surgical excision of primary tumor or at relapse. However, the relationship between undefined or overt metastases and the host immune system has not been sufficiently examined over a prolonged period. These aspects were investigated in 160 breast
A model based assessment of redistribution dependent elimination and bioavailability of rifabutin.: Biopharm Drug Dispos. 1996 Apr;17(3):223-36. Unique Identifier : AIDSLINE MED/97105486; Li RC; Narang PK; Poggesi I; Strolin-Benedetti M; Department of Clinical Pharmacology, Pharmacia Inc., Columbus,; OH, USA.; The autoinduction characteristic of rifabutin (RIF) following multiple oral dosing was investigated via pharmacokinetic modeling. A two-compartment model with first-order absorption was fit to plasma RIF data obtained from a study conducted in healthy normal volunteers following both a single and multiple oral doses.
HIV-1 infection kinetics in tissue cultures.: Math Biosci. 1996 Nov;138(1):1-22. Unique Identifier : AIDSLINE MED/97097568; Spouge JI; Shrager RI; Dimitrov DS; National Center for Biotechnology Information, National Library; of Medicine, Bethesda, Maryland, USA.; Despite intensive experimental work on HIV-1, very little theoretical work has focused on HIV-1 spread in tissue culture. This article uses two systems of ordinary differential equations to model two modes of viral spread, cell-free virus and cell-to-cell contact. The two models produce remarkably similar qualitative
Event-related potentials as indices of subclinical neurological differences in HIV patients during rapid decision making.: J Neuropsychiatry Clin Neurosci. 1996 Summer;8(3):293-304. Unique Identifier : AIDSLINE MED/97007026; Linnville SE; Elliott FS; Larson GE; Cognitive Performance and Psychophysiology Department, Naval; Health Research Center, San Diego, California, USA.; The authors examined decision making in HIV patients under slow and rapid information deliveries. Thirteen asymptomatic, HIV-infected (HIV+) subjects with known seroconversion dates and 13 healthy control subjects were instructed to detect the oddball target tones among nontarget tones during single-channel (slow) a
Consistency of repeated event-related potentials in clinically stable HIV-1-infected drug users.: J Neuropsychiatry Clin Neurosci. 1996 Summer;8(3):305-10. Unique Identifier : AIDSLINE MED/97007027; Schroeder MM; Handelsman L; Torres L; Jacobson J; Ritter W; Psychiatry Service, Veterans Affairs Medical Center, Bronx, NY; 10468, USA.; This study investigated the stability over time of delays in auditory event-related potentials (ERPs) caused by HIV-1 infection of the brain. ERPs were recorded at two time points from 17 former parenteral drug users (PDUs) and 8 non-PDU control subjects. There was no significant effect of time, and peak measures for
HIV positive surgeon allowed to operate [news]: BMJ. 1996 Nov 23;313(7068):1279. Unique Identifier : AIDSLINE MED/97098145; Christie B
Post-exposure prophylaxis after needlestick injuries would require change in management [letter]: BMJ. 1996 Nov 23;313(7068):1335. Unique Identifier : AIDSLINE MED/97098174; Neal TJ; Harvey G
Prevalence of markers for hepatitis B virus and HIV-1 among drug injectors in London: injecting careers, positivity and risk behaviour.: Addiction. 1996 Oct;91(10):1457-67. Unique Identifier : AIDSLINE MED/97075523; Rhodes T; Hunter GM; Stimson GV; Donoghoe MC; Noble A; Parry J; Chalmers C; Centre for Research on Drugs and Health Behaviour, University of; London, UK.; Concerns about the risks of HIV infection among drug injectors have eclipsed concerns about the prevalence and transmission of hepatitis, and in particular hepatitis B virus infection. Findings are reported from surveys undertaken with two separate community-recruited samples of drug injectors in London collected in 1
Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells.: Bone Marrow Transplant. 1996 Aug;18(2):285-92. Unique Identifier : AIDSLINE MED/97017819; Hayashi H; LeGuern C; Sachs DH; Sykes M; Transplantation Biology Research Center, Massachusetts General; Hospital, Boston 002129, USA.; Clinical application of approaches to inducing transplantation tolerance that involve bone marrow reconstitution will require achievement of engraftment without major toxicity to the recipient. These requirements are likely to vary according to the type of histoincompatibility between donor and recipient. We have atte
Eliminating graft-versus-host potential from T cell immunotherapeutic populations.: Bone Marrow Transplant. 1996 Aug;18(2):415-20. Unique Identifier : AIDSLINE MED/97017838; Rencher SD; Houston JA; Lockey TD; Hurwitz JL; Department of Immunology, St Jude Children's Research Hospital,; Memphis, TN 38101, USA.; It is common knowledge that donor T cells are responsible for graft-versus-host disease (GVHD) following bone marrow transplantation (BMT), yet GVHD remains a grave threat to transplant patients. The donor marrow can be purged of T cells to reduce this danger, but the risks of viral infections, tumor relapse and graft
The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.: Hum Mol Genet. 1996 Aug;5(8):1083-91. Unique Identifier : AIDSLINE MED/96440414; Eberhart DE; Malter HE; Feng Y; Warren ST; Howard Hughes Medical Institute, Emory University School of; Medicine, Atlanta, Georgia 30322, USA.; Fragile X syndrome is a frequent cause of mental retardation resulting from the absence of FMRP, the protein encoded by the FMR1 gene. FMRP is an RNA-binding protein of unknown function which is associated with ribosomes. To gain insight into FMRP function, we performed immunolocalization analysis of FMRP truncation a
[Orientations and present day possibilities for use of anti-HIV drugs]: Rev Assoc Med Bras. 1996 Jan-Mar;42(1):16-8. Unique Identifier : AIDSLINE MED/97089762; Amato Neto V; Pasternak J; Amato VS; Departamento de Doencas Infecciosas e Parasitarias,; Universidade de Sao Paulo, SP.
[Abdominal surgical emergencies in patients with acquired immunodeficiency syndrome]: Rev Assoc Med Bras. 1996 Jan-Mar;42(1):19-24. Unique Identifier : AIDSLINE MED/97089763; Steinman M; Steinman E; Poggetti RS; Birolini D; Servico de Cirurgia de Emergencia, Universidade de Sao Paulo,; SP.; Patients with Acquired Immunodeficiency Syndrome (AIDS) may present acute abdomen with modified clinical manifestations which may lead to errors and delays in preoperative diagnosis, with frequent delays in treatment. PURPOSE: To study clinical signs, diagnostic criteria, etiology, surgical management and mortality in
[Syphilis in HIV infected individuals]: Rev Assoc Med Bras. 1996 Jan-Mar;42(1):46-50. Unique Identifier : AIDSLINE MED/97089767; Frisoli Junior A; Castelo Filho A; Departamento de Doencas Infecciosas, Universidade Federal de; Sao Paulo, SP.
[Viral load and antiretroviral treatments in children infected by human immunodeficiency virus (letter)]: Arch Pediatr. 1996 Oct;3(10):1046-7. Unique Identifier : AIDSLINE MED/97110655; Monpoux F; Sirvent N; Cottalorda J; Mariani R; Lefebvre JC
The impact of human immunodeficiency virus infection on drug-resistant tuberculosis.: Am J Respir Crit Care Med. 1996 Nov;154(5):1478-83. Unique Identifier : AIDSLINE MED/97069788; Gordin FM; Nelson ET; Matts JP; Cohn DL; Ernst J; Benator D; Besch CL; Crane LR; Sampson JH; Bragg PS; El-Sadr W; Division of Infectious Diseases, Department of Veterans Affairs; Medical Center, Washington, DC, USA. Terry Beirn Community; Programs for Clinical Research on AIDS.; Infection with human immunodeficiency virus (HIV) has been associated with increased rates of single- and multidrug-resistant (MDR) tuberculosis in the New York City area. In order to examine the relationship of HIV infection to drug-resistant tuberculosis in other selected regions of the
[Pneumocystis carinii pneumonia in an HIV patient with negative exercise oxygen desaturation test (letter)]: Arch Bronconeumol. 1996 Oct;32(8):432. Unique Identifier : AIDSLINE MED/97093821; Donado Una JR; Yubero Salgado UL; Lopez Encuentra A
[Tumor necrosis factor alpha in pleural fluid in patients with pleural tuberculosis. Relation with human immunodeficiency virus infection (letter)]: Arch Bronconeumol. 1996 Oct;32(8):434. Unique Identifier : AIDSLINE MED/97093824; Villena MV; Echave-Sustaeta JM; Lopez Encuentra A
Sharing research findings with the communities studied: the case of the Women and AIDS Support Network Research Project in Zimbabwe.: Promot Educ. 1996 Sep;3(3):33-7, 48. Unique Identifier : AIDSLINE MED/97082320; McCharen N; Sandasi M; WASN, Harare, Zimbabwe.
Pictorial review: the radiological spectrum of vertically-acquired HIV infection.: Br J Radiol. 1996 Aug;69(824):777-82. Unique Identifier : AIDSLINE MED/97106935; Owens CM; Allan R; Thomas K; Evans J; Stevens J; Department of Diagnostic Radiology, St Mary's Hospital and; Medical School, London, UK.; Anonymous antenatal and newborn screening demonstrates a positive HIV seroprevalence of one in 400 in areas of inner city London. European Collaborative Study data show a vertical transmission rate of 15% and suggests that 23% of infected children will develop clinical manifestations of AIDS before reaching 1 year of
Technique of laparoscopic splenectomy with a powered vascular linear stapler.: Br J Surg. 1996 Sep;83(9):1212-4. Unique Identifier : AIDSLINE MED/97105430; Miles WF; Greig JD; Wilson RG; Nixon SJ; Department of Surgery, Western General Hospital, Edinburgh, UK.; The spleen may be removed by a laparoscopic technique, although the benefits and associated morbidity of this approach are unknown. This study reports a series of 28 consecutive patients (15 women; median age 39 (range 17-84) years) considered for laparoscopic splenectomy, because of idiopathic thrombocytopenia in 14,
Deep penetration of an alpha-helix into a widened RNA major groove in the HIV-1 rev peptide-RNA aptamer complex.: Nat Struct Biol. 1996 Dec;3(12):1026-33. Unique Identifier : AIDSLINE MED/97102429; Ye X; Gorin A; Ellington AD; Patel DJ; Cellular Biochemistry and Biophysics Program Memorial; Sloan-Kettering Cancer Center, New York, New York 10021, USA.; A combined NMR-molecular dynamics approach has been applied to determine the solution structure of a HIV-1 17-mer rev peptide bound to its 35-mer high affinity RNA aptamer binding site. Complex formation involves adaptive binding with the alpha-helical arginine-rich basic rev peptide targeting a widened RNA major groo
An RNA groove [news]: Nat Struct Biol. 1996 Dec;3(12):981-4. Unique Identifier : AIDSLINE MED/97102419; Ellington AD; Leclerc F; Cedergren R
Misprint of dosage interval for liposomal doxorubicin hydrochloride [letter]: Am J Health Syst Pharm. 1996 Jul 15;53(14):1727. Unique Identifier : AIDSLINE MED/96424783; Subach RA; Ruble J
Incorporation of nuclear matrix attachment regions into the herpes simplex virus type 1 genome does not induce long-term expression of a foreign gene during latency.: Gene Ther. 1996 Sep;3(9):829-33. Unique Identifier : AIDSLINE MED/97029221; Makarova O; Gorneva G; Wu F; Farutin V; Villeponteau B; Poliani L; Fink D; Levine M; Department of Human Genetics, University of Michigan, Ann Arbor; 48109-0618, USA.; The nuclear matrix plays a critical role in DNA replication, gene transcription and RNA processing. Transcriptionally active genes are usually associated with the nuclear matrix through DNA sequences, matrix attachment regions or MARs, which tether looped DNA to the matrix. In stable transfection and in transgenic mic
Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.: Immunity. 1996 Nov;5(5):461-77. Unique Identifier : AIDSLINE MED/97088665; Lucas B; Germain RN; Laboratory of Immunology, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-1892, USA.; CD4+ CD8+ TCRlo thymocytes are the precursors of CD4+ and CD8+ mature T cells, whose receptors show specific recognition of peptide-MHC class II and MHC class I complexes, respectively. How T cells emerge from the intrathymic differentiation process with selective expression of either CD8 molecule or CD4 molecule coor
Interferon-gamma in autoimmunity.: Cytokine Growth Factor Rev. 1996 Jun;7(1):25-34. Unique Identifier : AIDSLINE MED/97017735; Billiau A; Laboratory of Immunobiology, Rega Institute, University of; Leuven, Belgium.; Autoimmune disorders are characterized by abrogation of self-tolerance, resulting in emergence of activated self-reactive lymphocyte clones that trigger or maintain inflammatory reactions in specific organs. Interferon-gamma (IFN-gamma), as well as other cytokines, plays an important role as a regulator of the activat
Chemokine receptors: structure, function and role in microbial pathogenesis.: Cytokine Growth Factor Rev. 1996 Jun;7(1):47-64. Unique Identifier : AIDSLINE MED/97017737; Murphy PM; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; The chemokine superfamily is composed of at least 20 different leukocyte chemoattractants that act by binding to a family of G protein-coupled receptors. Leukocyte subtypes respond preferentially to unique but overlapping subsets of chemokines as determined by the receptor distribution, yet the receptors appear to sig
Hepatitis E virus infection in north-east Italy: serological study in the open population and groups at risk.: J Viral Hepat. 1996 Jul;3(4):197-202. Unique Identifier : AIDSLINE MED/97025702; Gessoni G; Manoni F; Transfusional Centre, Community Hospital, Chioggia (Venice),; Italy.; Developed western countries are considered to be relatively free from endemic foci of hepatitis E virus (HEV) infections. The aim of this study was to assess the seroepidemiology of HEV in north-east Italy . Of the 2361 individuals studied 1889 were representative of the general popu
Chemokines and HIV-1 second receptors. Confluence of two fields generates optimism in AIDS research.: Nat Med. 1996 Dec;2(12):1293-300. Unique Identifier : AIDSLINE MED/97102392; D'Souza MP; Harden VA; Pathogenesis and Basic Research Branch, Division of AIDS,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892, USA.
From Th1 to Th2: diabetes immunotherapy shifts gears [news; comment]: Nat Med. 1996 Dec;2(12):1311-2. Unique Identifier : AIDSLINE MED/97102399; Solimena M; De Camilli P
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice [see comments]: Nat Med. 1996 Dec;2(12):1348-53. Unique Identifier : AIDSLINE MED/97102407; Tian J; Clare-Salzler M; Herschenfeld A; Middleton B; Newman D; Mueller R; Arita S; Evans C; Atkinson MA; Mullen Y; Sarvetnick N; Tobin AJ; Lehmann PV; Kaufman DL; Department of Molecular and Medical Pharmacology, University of; California-Los Angeles 90095, USA.; In nonobese diabetic (NOD) mice, beta-cell reactive T-helper type 1 (Th1) responses develop spontaneously and gradually spread, creating a cascade of responses that ultimately destroys the beta-cells. The diversity of the autoreactive T-cell repertoire creates a major obstacle to the development of therapeutics. We sh
The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells.: Nat Med. 1996 Dec;2(12):1371-5. Unique Identifier : AIDSLINE MED/97102411; Albini A; Soldi R; Giunciuglio D; Giraudo E; Benelli R; Primo L; Noonan D; Salio M; Camussi G; Rockl W; Bussolino F; Dipartimento di Genetica, Biologia e Chimica Medica, Universita; di Torino, Turin, Italy.; The HIV-1 Tat protein transactivates HIV, viral and some host cell genes. Tat can be released by infected cells and acts extracellularly in the microenvironment, regulating functions of immunocompetent and mesenchymal cells. One of the most striking effects of Tat is the induction of a functional program in vascular c
Epstein-Barr virus-driven gene therapy for EBV-related lymphomas.: Nat Med. 1996 Dec;2(12):1379-82. Unique Identifier : AIDSLINE MED/97102413; Franken M; Estabrooks A; Cavacini L; Sherburne B; Wang F; Scadden DT; Division of Hematology/Oncology, Harvard Medical School, Boston,; Massachusetts, USA.; Genetic alterations in malignant tissues are potential targets for gene-based cancer therapies. Alternatively, aberrant expression of certain specific genes associated with malignant transformation may be envisioned to enhance the expression of chemosensitizing drugs. Epstein-Barr virus (EBV)-related B-cell lymphomas
Indeterminate results of HIV testing: explanation and clinical management.: Med Health R I. 1996 Oct;79(10):360-2. Unique Identifier : AIDSLINE MED/97097574; Elliot BC; Rogers M; Rich JD; Division of Geographic Medicine, Miriam Hospital, Providence, RI; 02906, USA.
Point of view: HIV and competitive athletics--assessing the real risk of infection.: Med Health R I. 1996 Oct;79(10):362-4. Unique Identifier : AIDSLINE MED/97097575; Feller AA; Flanigan TP; Division of Clinical Immunology, Miriam Hospital, USA.; afeller@brynmawr.edu
Disputes use of the term "homeopathic" [letter]: Altern Ther Health Med. 1996 Nov;2(6):15-6. Unique Identifier : AIDSLINE MED/97097414; Jacobs J; Goldman E
Defining homeopathic growth factors [letter]: Altern Ther Health Med. 1996 Nov;2(6):16-7. Unique Identifier : AIDSLINE MED/97097415; Brewitt B
Partner notification program and possibility of including it in the HIV prevention strategies in Japan.: J Epidemiol. 1996 Sep;6(3):158-65. Unique Identifier : AIDSLINE MED/97109985; Rahman M; Fukui T; Department of General Medicine and Clinical Epidemiology, Kyoto; University Hospital, Japan.; This article discusses the possibility of implementing partner notification program as a part of HIV prevention strategy in Japan . Relevant factors, like HIV seroprevalence, general population attitudes toward HIV, legislation, resources, barriers, behavioral changes, cost and effec
A tumor-specific Th2 clone initiating tumor rejection via primed CD8+ cytotoxic T-lymphocyte activation in mice.: Cancer Res. 1996 Nov 1;56(21):5005-11. Unique Identifier : AIDSLINE MED/97051018; Shen Y; Fujimoto S; Department of Immunology, Kochi Medical School, Nankoku-shi,; Japan.; We established a CD4+ T-cell clone specific for syngeneic methylcholanthrene-induced sarcoma, S1509a raised in an A/J mouse, involved in tumor regression. The phenotype of the T-cell clone was CD3+, TCR-beta+, CD4+, CD45RB+, LFA-1+, ICAM-1+, CD44+, and VLA-4+. The CD4+ T-cell clone specifically proliferated through an
The adeno-associated virus Rep78 major regulatory/transformation suppressor protein binds cellular Sp1 in vitro and evidence of a biological effect.: Cancer Res. 1996 Nov 15;56(22):5299-304. Unique Identifier : AIDSLINE MED/97069892; Hermonat PL; Santin AD; Batchu RB; Department of Obstetrics and Gynecology, University of Arkansas; for Medical Sciences, Little Rock 72205, USA.; Adeno-associated virus (AAV) Rep78 is a multifunctional protein that is required for AAV transcriptional activity, AAV DNA replication, and possibly for site-specific integration of AAV into human chromosome 19. Rep78 is also able to inhibit a variety of heterologous promoters, including those of c-H-ras, human papill
Pathogenesis of HIV-1 associated neurodegeneration.: Crit Rev Neurobiol. 1996;10(1):57-67. Unique Identifier : AIDSLINE MED/97006661; Masliah E; Ge N; Mucke L; Department of Neurosciences, University of California, San Diego,; La Jolla 92093-0624, USA.; A significant number of people infected with the human immunodeficiency virus (HIV) develop neurologic complications. The AIDS dementia complex is frequently accompanied by HIV encephalitis, which is characterized at the neuropathologic level by loss of neuronal subpopulations in t
Multiple dermatofibromas in a patient with HIV infection.: Clin Exp Dermatol. 1995 Nov;20(6):474-6. Unique Identifier : AIDSLINE MED/97010279; Armstrong DK; Irvine A; Walsh MY; Mayne EE; Burrows D; Department of Dermatology, Royal Victoria Hospital, Belfast,; Northern Ireland, UK.; We report the case of a 26-year-old man with haemophilia B and human immunodeficiency virus infection (HIV) who presented with a short history of multiple dermatofibromas. He also had troublesome psoriasis for which he was receiving acitretin with UVB therapy and had recently discontinued low-dose daily prednisolone f
Cutaneous cryptococcosis and Kaposi's sarcoma occurring in the same lesions in a patient with the acquired immunodeficiency syndrome.: Clin Exp Dermatol. 1995 Nov;20(6):480-6. Unique Identifier : AIDSLINE MED/97010281; Glassman SJ; Hale MJ; Division of Dermatology, Department of Medicine, University of; the Witwatersrand, Johannesburg, South Africa.; A 34-year-old woman presented with a history of fever, malaise and skin lesions. A diagnosis of Kaposi s sarcoma and acquired immunodeficiency syndrome (AIDS) was established, and in addition, the skin lesion which was biopsied also demonstrated cryptococcal infection. Disseminated cryptococcosis was later confirmed a
Predictor of the rate of CD4 lymphocyte loss in HIV-1-seropositive asymptomatic hemophiliacs by in vitro immunoglobulin synthesis.: Clin Immunol Immunopathol. 1996 Dec;81(3):224-8. Unique Identifier : AIDSLINE MED/97092678; Cavallin F; Traldi A; di Gaetano R; De Biasi E; Davoli G; Gajo G; Tagariello G; Zambello R; Centro per le Malattie del Sangue, Castelfranco Veneto Hospital,; Treviso, Italy.; The objective of the present study was to evaluate the prognostic utility in determining the risk of AIDS progression in HIV-1-infected asymptomatic hemophiliacs by in vitro immunoglobulin (Ig) synthesis. With this aim, a cohort of 28 HIV-1-seropositive hemophiliacs were studied. All showed the number of CD4 lymphocyt
Contribution of Thy-1-CD4+ T cells to the disorganization of lymphoid follicles in retrovirus-induced immunodeficiency syndrome, MAIDS.: Clin Immunol Immunopathol. 1996 Dec;81(3):253-60. Unique Identifier : AIDSLINE MED/97092682; Masuda A; Makino M; Kasajima T; Department of Pathology, Tokyo Women's Medical College, Japan.; The destruction of the lymphoid follicle (LF) and of the follicular dendritic cell network in the secondary lymphoid organs are major pathological features in murine acquired immunodeficiency syndrome (MAIDS). These pathological changes are associated with functional deficiency of lymphocytes. However, the mechanisms
Characterization of the antigen-presenting cell and T cell requirements for induction of pulmonary eosinophilia in a murine model of asthma.: Clin Immunol Immunopathol. 1996 Dec;81(3):307-11. Unique Identifier : AIDSLINE MED/97092690; Lambert LE; Berling JS; Kudlacz EM; Immunoinflammatory Research, Hoechst Marion Roussel, Cincinnati,; Ohio 45215, USA.; A model of allergic pulmonary inflammation is described in which the intraperitoneal injection of antigen (Ag)-pulsed cells resulted in T cell priming. Mice received two injections of 10(6) elicited peritoneal macrophages, which had been incubated with Ag for 48 hr, on Days 0 and 6, followed by an aerosol Ag challenge
Clinical pharmacokinetics of zidovudine. An update.: Clin Pharmacokinet. 1996 Apr;30(4):251-62. Unique Identifier : AIDSLINE MED/97104910; Acosta EP; Page LM; Fletcher CV; Department of Pharmacy Practice, University of Minnesota,; Minneapolis, USA.; The battle against the acquired immune deficiency syndrome (AIDS) is now into its second decade, and substantial advancements have been made in our understanding of the complex life cycle of, and the immunopathology associated with, human immunodeficiency virus (HIV) infection, as well as of the drugs used to modify t
Pharmacokinetic individualisation of zidovudine therapy. Current state of pharmacokinetic-pharmacodynamic relationships.: Clin Pharmacokinet. 1996 Apr;30(4):314-27. Unique Identifier : AIDSLINE MED/97104913; Hoetelmans RM; Burger DM; Meenhorst PL; Beijnen JH; Department of Pharmacy, Slotervaart Hospital, Amsterdam,; Netherlands.; Zidovudine is the cornerstone of current antiretroviral treatment of human immunodeficiency virus (HIV) infection. Its use, however, frequently leads to adverse reactions, including myelosuppression. Zidovudine pharmacokinetics show large interindividual variation with indications of pharmacokinetic-pharmacodynamic re
The spectrum of MRI findings in CNS cryptococcosis in AIDS.: Clin Radiol. 1996 Dec;51(12):842-50. Unique Identifier : AIDSLINE MED/97127970; Miszkiel KA; Hall-Craggs MA; Miller RF; Kendall BE; Wilkinson ID; Paley MN; Harrison MJ; Imaging Department, UCL Hospital (NHS) Trust, London UK.; We retrospectively reviewed the cranial MRI appearances of 25 patients with AIDS and microbiologically proven central nervous system (CNS) cryptococcosis. Four patients had a normal scan. Ten patients had dilated perivascular Virchow-Robin spaces that were hyperintense on T2-weighted images. Nine of these patients dev
Tuberculosis bacteriology laboratory services and incremental protocols for developing countries.: Clin Lab Med. 1996 Sep;16(3):697-716. Unique Identifier : AIDSLINE MED/97019713; Laszlo A; National Reference Center for Tuberculosis, Laboratory Center for; Disease Control, Health Canada, Ottawa, Ontario, Canada.; Tuberculosis causes more deaths worldwide than any other single infectious disease. Most new cases occur in developing countries, where the emergence of HIV/AIDS-associated multidrug-resistant Mycobacterium tuberculosis could disrupt the effective delivery of chemotherapy. Diagnosis, one of the cornerstones of the mod
Childhood dermatitis in the tropics: with special emphasis on infective dermatitis, a marker for infection with human T-cell leukemia virus-I.: Cutis. 1996 Aug;58(2):115-8. Unique Identifier : AIDSLINE MED/97017981; La Grenade L; Schwartz RA; Janniger CK; University of the West Indies Faculty of Medical Science, Mona,; Jamaica.
Effect of isoprinosine on 3'-Azido-3'-deoxythymidine uptake and phosphorylation in human peripheral blood mononuclear cells.: Chemotherapy. 1996 May-Jun;42(3):192-8. Unique Identifier : AIDSLINE MED/97104918; Riva C; Barra Y; Groupe de Recherche sur les Cancers du Poumon et des Voies; Aeriennes, Universite Joseph-Fourier, La Tronche, France.; The effect of the immunomodulating agent Isoprinosine on AZT uptake and phosphorylation in human blood monocytes/macrophages was examined. AZT (1-15 microM) uptake in monocytes/macrophages was rapid and dose- and time-dependent. The main metabolite fo
Oral fluconazole in the treatment of pulmonary cryptococcosis in non-AIDS patients.: Drugs Exp Clin Res. 1996;22(1):25-8. Unique Identifier : AIDSLINE MED/96436818; Yew WW; Wong PC; Wong CF; Lee J; Chau CH; Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong.; Four non-AIDS patients with pulmonary cryptococcus infection who could not tolerate amphotericin B treatment were given oral fluconazole at a dose of 600 mg once daily for 4-5 weeks followed by 400 mg once daily for 10-12 weeks resulting in cure. All patients did not have relapse of disease when followed-up for 8-24 m
Diagnosis and management of complications of self-injection injuries of the neck.: Ear Nose Throat J. 1996 Oct;75(10):670-6. Unique Identifier : AIDSLINE MED/97097470; Kay DJ; Mirza N; Philadelphia Veterans Affairs Medical Center, University of; Pennsylvania School of Medicine, USA.; When IVDUs who lose peripheral access turn to their necks, they invite a spectrum of unique complications that require particular management and treatment. While many of these complications are infectious, other possibilities include vocal cord paralysis and needle fragment foreign bodies. Work-up of these patients mu
Angiocentric T-cell lymphoma of the tonsil: a case report.: Ear Nose Throat J. 1996 May;75(5):309-11. Unique Identifier : AIDSLINE MED/97089623; Helfend LK; Finkle HI; Freedman HM; Department of Pathology and Clinical Laboratories, Alameda County; Medical Center, Highland Campus, Oakland, California 94602, USA.; We present a case of an angiocentric T-cell lymphoma (ACTL) occurring in a 31-year-old woman with the Acquired Immunodeficiency Syndrome (AIDS). This patient had oropharyngeal pain, a non-healing superficially ulcerated right tonsil, and no obvious tumor mass. Initial tonsillar biopsy revealed a subtle, non-specific,
Elevated physical health risk among gay men who conceal their homosexual identity.: Health Psychol. 1996 Jul;15(4):243-51. Unique Identifier : AIDSLINE MED/96415763; Cole SW; Kemeny ME; Taylor SE; Visscher BR; Department of Psychology, University of California, Los Angeles; 90024-1563, USA coles@nicco.sscnet.ucla.edu; This study examined the incidence of infectious and neoplastic diseases among 222 HIV-seronegative gay men who participated in the Natural History of AIDS Psychosocial Study. Those who concealed the expression of their homosexual identity experienced a significantly higher incidence of cancer (odds ratio = 3.18) and s
Testing for HIV and other sexually transmitted diseases: implications for risk behavior in women.: Health Psychol. 1996 Jul;15(4):252-60. Unique Identifier : AIDSLINE MED/96415764; Wilson TE; Jaccard J; Levinson RA; Minkoff H; Endias R; State University of New York Health Science Center at Brooklyn; 11203, USA.; A sample of 808 nonpregnant women residing in an area of high prevalence of sexually transmitted diseases (STDs) was studied with respect to sexual risk behaviors in the 4-month period before and after testing for a series of STDs. All women were tested for both Chlamydia trachomatis and Trichomonas vaginalis and were
Direct interaction between the envelope and matrix proteins of HIV-1.: EMBO J. 1996 Nov 1;15(21):5783-8. Unique Identifier : AIDSLINE MED/97076138; Cosson P; Basel Institute for Immunology, Switzerland.; The incorporation of the envelope (env) glycoprotein of the human immunodeficiency virus type 1 (HIV-1) into budding virions has been proposed to be mediated by an interaction between its cytoplasmic domain and the matrix protein of HIV-1. However, this interaction was never directly demonstrated and its role in the b
Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).: EMBO J. 1996 Nov 15;15(22):6155-65. Unique Identifier : AIDSLINE MED/97102797; Fletcher TM 3rd; Brichacek B; Sharova N; Newman MA; Stivahtis G; Sharp PM; Emerman M; Hahn BH; Stevenson M; Department of Medicine, University of Alabama, Birmingham 35294,; USA.; The vpr genes of human and simian immunodeficiency viruses (HIV/SIV) encode proteins which are packaged in the virus particle. HIV-1 Vpr has been shown to mediate the nuclear import of viral reverse transcription complexes in non-dividing target cells (e.g. terminally differentiated macrophages), and to alter the cell
Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus.: Eur J Biochem. 1996 Oct 15;241(2):664-74. Unique Identifier : AIDSLINE MED/97075043; Powell DJ; Bur D; Wlodawer A; Gustchina A; Payne SL; Dunn BM; Kay J; School of Molecular and Medical Biosciences, University of Wales; College of Cardiff, UK.; The gene encoding the proteinase from equine infectious anaemia virus (EIAV) was cloned and expressed in Escherichia coli. The recombinant EIAV proteinase was purified to homogeneity and shown to have the ability to process polyprotein and synthetic peptide substrates of human immunodeficiency virus (HIV) origin with
Strained template under the thumbs. How reverse transcriptase of human immunodeficiency virus type 1 moves along its template.: Eur J Biochem. 1996 Nov 15;242(1):98-103. Unique Identifier : AIDSLINE MED/97112479; Hermann T; Heumann H; Max-Planck-Institut fur Biochemie, Martinsried, Germany.; In retroviruses, such as human immunodeficiency virus type 1 (HIV-1), the reverse transcriptase (RT) copies single-stranded viral RNA into complementary DNA, which is then used as a template for synthesis of the second DNA strand. The resulting double-stranded DNA is integrated into the host genome. How RT translocate
Rapidly progressive hepatitis C in a patient with common variable immunodeficiency.: Eur J Pediatr. 1996 Jul;155(7):532-4. Unique Identifier : AIDSLINE MED/96427756; Sumazaki R; Matsubara T; Aoki T; Nagai Y; Shibasaki M; Takita H; Department of Paediatrics, University of Tsukuba, Ibaraki, Japan.; A 15-year-old girl with common variable immunodeficiency contracted hepatitis C, which progressed to liver cirrhosis and finally to hepatic failure 5 years later. Since she was agammaglobulinaemic, hepatitis C virus (HCV) infection was diagnosed on the basis of HCV-RNA detection. Quantification of her sera showed high
An analysis of the normal ranges of lymphocyte subpopulations in children aged 5-13 years.: Eur J Pediatr. 1996 Jul;155(7):535-9. Unique Identifier : AIDSLINE MED/96427757; Robinson M; O'Donohoe J; Dadian G; Wankowicz A; Barltrop D; Hobbs JR; Department of Immunology, Charing Cross and Westminster Medical; School, London, UK.; Peripheral blood lymphocytes subsets were examined in 233 healthy school children aged 4.9-13.7 years at the time of examination. Lymphocyte subsets were characterized according to the following cluster of differentiation (CD) numbers: CD2, CD4, CD8 and CD19 and quantified according to both their absolute number and a
Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8+ cytotoxic T lymphocytes.: Eur J Immunol. 1996 Nov;26(11):2595-600. Unique Identifier : AIDSLINE MED/97080599; Bachmann MF; Lutz MB; Layton GT; Harris SJ; Fehr T; Rescigno M; Ricciardi-Castagnoli P; Department of Pathology, University of Zurich, Switzerland.; Previous reports have indicated that both dendritic cells and macrophages have the ability to induce cytotoxic T lymphocyte (CTL) and T helper (Th) cell responses in vivo. Dendritic cells process exogenous antigens conventionally for presentation on major histocompatibility complex (MHC) class II molecules. However, u
Diversion of CD4+ T cell development from regulatory T helper to effector T helper cells alters the contact hypersensitivity response.: Eur J Immunol. 1996 Nov;26(11):2606-12. Unique Identifier : AIDSLINE MED/97080601; DiIulio NA; Xu H; Fairchild RL; Department of Immunology, Cleveland Clinic Foundation, OH 44195,; USA. diiulin@cesmtp.ccf.org; Cutaneous sensitization to reactive haptens and subsequent challenge results in a T cell-mediated response, contact hypersensitivity (CHS). Recent results from this laboratory have indicated that hapten sensitization induces two populations of reactive T cells: CD8+ T cells producing interferon (IFN)-gamma which media
Cellular competition modulates survival and selection of CD8+ T cells.: Eur J Immunol. 1996 Nov;26(11):2640-9. Unique Identifier : AIDSLINE MED/97080605; Freitas AA; Agenes F; Coutinho GC; Laboratoire des Dynamiques Lymphocytaires, CNRS URA1961 Institut; Pasteur, Paris, France. afreitas@pasteuer.fr; In this investigation we compare the repopulation of the CD8+ T cell compartments of bone marrow (BM) chimeras by either normal nontransgenic or T cell receptor (TcR) alpha beta-transgenic (TG) CD8+ T cells, the fate of TG and non-TG CD8+ T cells in different parabionts and the survival of TG and non-TG peripheral CD8
Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects.: Eur J Immunol. 1996 Nov;26(11):2666-70. Unique Identifier : AIDSLINE MED/97080608; Barrios C; Brandt C; Berney M; Lambert PH; Siegrist CA; W.H.O. Collaborating Centre for Neonatal Vaccinology, University; of Geneva, Switzerland.; We have recently shown that neonatal responses to a pannel of vaccine antigens and presentation systems differed qualitatively from adult responses by a bias towards a TH2 pattern. Here we report that a selected adjuvant comprising block copolymers in a water-in-oil emulsion can induce balanced TH1/TH2 responses in BA
CD4+CD8- thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer.: Eur J Immunol. 1996 Nov;26(11):2702-8. Unique Identifier : AIDSLINE MED/97080613; Seddon B; Saoudi A; Nicholson M; Mason D; MRC Cellular Immunology Unit, Sir William Dunn School of; Pathology, University of Oxford, GB.; Previous studies have shown that insulin-dependent diabetes can be induced in normal PVG.RT1u rats by a protocol of adult thymectomy and irradiation. The injection of CD4+ T cells from non-irradiated syngeneic donors prevents the onset of disease in approximately 50% of pre-diabetic recipients but all rats are protect
Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12.: Eur J Immunol. 1996 Nov;26(11):2709-16. Unique Identifier : AIDSLINE MED/97080614; Eberl G; Kessler B; Eberl LP; Brunda MJ; Valmori D; Corradin G; Institute of Biochemistry, University of Lausanne, Epalinges,; Switzerland.; Immunodominance (ID) of T cell epitopes is a well-documented phenomenon that might have profound significance in the evolution of T cell responses to pathogens, tumors, autoantigens and vaccines. With the intention of developing vaccines composed of several cytotoxic T cell (CTL) epitopes, we injected mice with peptid
(s4dU)35: a novel, highly potent oligonucleotide inhibitor of the human immunodeficiency virus type 1 reverse transcriptase.: FEBS Lett. 1996 Oct 28;396(1):43-6. Unique Identifier : AIDSLINE MED/97064244; Tokes S; Aradi J; Department of Biochemistry, University Medical School of; Debrecen, Hungary.; Oligodeoxycytidylates were converted to s4dUMP-containing oligomers by treatment with liquid H2S. The inhibitory potency of the modified oligonucleotides on human immunodeficiency virus type 1 reverse transcriptase depended on the chain length and on the percentage of modification. The most potent reverse transcriptas
Enhancement of nucleocytoplasmic export of HTLV-1 Rex mRNA through cis and trans interactions of the mRNA with the complex of Rex protein and Rex-responsive element.: FEBS Lett. 1996 Oct 28;396(1):47-52. Unique Identifier : AIDSLINE MED/97064245; Fu L; White KN; Division of Biochemistry and Molecular Biology, United Medical; and Dental Schools of Guy's and St. Thomas's Hospitals, London,; UK.; p27 rex of HTLV-1 promotes nucleocytoplasmic export of viral mRNAs through binding of the Rex-response element (RexRE) present at the 3 end of the viral transcripts in cis with respect to the ORFs of the viral mRNAs. We have found that expression of the RexRE in trans, as a separate RNA, still allows Rex protein to p
Visual prognosis of AIDS patients with cytomegalovirus retinitis.: Eye. 1995;9 ( Pt 6):697-702. Unique Identifier : AIDSLINE MED/97002136; Bloom PA; Sandy CJ; Migdal CS; Stanbury R; Graham EM; The Western Eye Hospital, London, UK.; A prospective study of visual acuity (VA) was performed in a cohort of 147 AIDS patients with cytomegalovirus retinitis (CMVR). Patients were treated according to standard regimes, and corrected VA was recorded at regular intervals from presentation until death. Follow-up was 6 wee
Kaposi's sarcoma of the skin. Consider HIV testing in older patients with this malignant neoplasm.: Geriatrics. 1996 Dec;51(12):21,51. Unique Identifier : AIDSLINE MED/97123040; Gross JS; Shua-Haim JR
[Septic arthritis in an HIV-positive hemophiliac]: Harefuah. 1996 Sep;131(5-6):145-6, 216. Unique Identifier : AIDSLINE MED/97095086; Bar Dayan Y; Levi Y; Shoenfeld Y; Medical Dept. B, Chaim Sheba Medical Center, Tel Hashomer.; Despite the high frequency of bacterial infections in HIV-positive patients, septic arthritis is rare, but it is increasing in HIV-positive hemophiliacs. We describe an HIV-positive male hemophilic, aged 38, with septic arthritis who was treated unsuccessfully with antibiotics for 4 days. Synovial fluid was then aspir
[Musculoskeletal infections in HIV-positive patients]: Harefuah. 1996 Sep;131(5-6):181-4. Unique Identifier : AIDSLINE MED/97095098; Melamed EA; Zinman C; Reis HD
[Th1/Th2 cells and autoimmunity]: Harefuah. 1996 Sep;131(5-6):189-92. Unique Identifier : AIDSLINE MED/97095100; Amital H; Blank M; Shoenfeld Y
[Artificial insemination in the AIDS era]: Harefuah. 1996 Oct;131(7-8):252-4. Unique Identifier : AIDSLINE MED/97095115; Paz G; Yogev L; Yavetz H
[Pathobiology of AIDS in the central nervous system--an epidemic with an elusive pathobiology]: Harefuah. 1996 Oct;131(7-8):285-8. Unique Identifier : AIDSLINE MED/97095124; Kristt D; Feinmesser M
Humoral and cellular immune responses to hepatitis B vaccination in hepatitis B surface antigen-carrier children who cleared serum-hepatitis B surface antigen.: Hepatology. 1996 Dec;24(6):1355-60. Unique Identifier : AIDSLINE MED/97092741; Hsu HY; Chang MH; Hsieh RP; Ni YH; Chi WK; Department of Emergency Medicine, College of Medicine, National; Taiwan University, Taipei.; The immune responses to hepatitis B vaccine were studied in 11 hepatitis B surface antigen (HBsAg) carrier children who had cleared HBsAg but failed to develop hepatitis B surface antigen antibodies (anti-HBs) in sera (group 1), 5 HBsAg carrier children who had cleared HBsAg and developed detectable anti-HBs in sera (
Incarceration and the acquired immunodeficiency syndrome: autopsy results in Texas prison inmates.: Hum Pathol. 1996 Dec;27(12):1282-7. Unique Identifier : AIDSLINE MED/97117230; Gelman BB; Wolf DA; Olano JP; Linthicum LC; Department of Pathology, The University of Texas Medical Branch,; Galveston 77550, USA.; The Texas Department of Criminal Justice (TDCJ) houses many subjects with acquired immunodeficiency syndrome (AIDS) who receive medical care in a comprehensive AIDS treatment center. In this case-control autopsy survey, we compared pathological outcomes of TDCJ inmates treated at the center (n = 155) with nonincarcera
Peripheral CD4+ CD8- gammadelta T cell lymphoma: a case report with multiparameter analyses.: Hum Pathol. 1996 Dec;27(12):1370-7. Unique Identifier : AIDSLINE MED/97117245; Ichinohasama R; Miura I; Takahashi T; Yaginuma Y; Myers J; DeCoteau JF; Yee C; Kadin ME; Mori S; Sawai T; Department of Pathology, Tohoku University Hospital, Aoba-ku,; Sendai, Japan.; A 72-year-old Japanese man presented with CD4+ T cell receptor (TCR) gammadelta T cell lymphoma involving bilateral cervical lymph nodes. No involvement by tumor was observed in the liver, spleen, nasal cavity, or bone marrow throughout his clinical course. Although the tumor adequately responded to chemotherapy and i
Molecular characterization of the V regions of four IgE antibodies specific for trichosanthin.: Immunology. 1996 Nov;89(3):316-23. Unique Identifier : AIDSLINE MED/97116957; Wang Y; Yeh M; Shanghai Institute of Cell Biology, Chinese Academy of Sciences,; China.; We report here the cDNA cloning and variable region nucleic acid sequences of the heavy and the light chains of four monoclonal IgE and one monoclonal IgG1 antibodies against trichosanthin (TCS), all of which recognized a similar or related antigenic determinant. Sequence analysis revealed that the VH regions of the f
Costimulatory signalling potential of murine MHC class II-positive T-clone cells.: Immunology. 1996 Nov;89(3):384-90. Unique Identifier : AIDSLINE MED/97116966; Frosch S; Bonifas U; Ross R; Schwing J; Yagita H; Guo Y; Liu Y; Reske-Kunz AB; Department of Dermatology, Johannes Gutenberg-University, Mainz,; Germany.; Activated human and rat T cells as well as mouse T-cell clones have been reported to synthesize and express major histocompatibility complex (MHC) class II molecules. However, the capacity of class II+ antigen (Ag) presenting T cells to induce proliferation of Ag-specific cloned T cells has been controversial. We anal
Thymocyte emigration in the chicken: an over-representation of CD4+ cells over CD8+ in the periphery.: Immunology. 1996 Nov;89(3):419-23. Unique Identifier : AIDSLINE MED/97116971; Katevuo K; Vainio O; Basel Institute for Immunology, Switzerland.; We have examined the emigration of chicken thymocytes after intrathymic fluorescein isothiocyanate (FITC) labelling in situ. In this paper we show that in young birds about 0.7% and 0.4% of thymocytes emigrate from the thymus to the blood and the spleen, respectively, per day. This suggests that, as in mammals, most t
Control by H-2 genes of the Th1 response induced against a foreign antigen expressed by attenuated Salmonella typhimurium.: Infect Immun. 1996 Nov;64(11):4424-32. Unique Identifier : AIDSLINE MED/97045122; Lo-Man R; Martineau P; Deriaud E; Newton SM; Jehanno M; Clement JM; Fayolle C; Hofnung M; Leclerc CD; Unite de Biologie des Regulations Immunitaires, Institut; Pasteur, Paris, France.; Attenuated salmonellae represent an attractive vehicle for the delivery of heterologous protective antigens to the immune system. Here, we have investigated the influence of the genetic background of the host which regulates the growth and elimination of Salmonella cells on the cellular response induced against a fore
Pneumocystis carinii pneumonia in scid mice induced by viable organisms propagated in vitro.: Infect Immun. 1996 Nov;64(11):4643-7. Unique Identifier : AIDSLINE MED/97045154; Beck JM; Newbury RL; Palmer BE; Division of Pulmonary and Critical Care Medicine, Department of; Internal Medicine, University of Michigan Medical Center, Ann; Arbor 48105, USA. jamebeck@umich.edu.; Pneumocystis carinii pneumonia remains a major cause of morbidity and mortality in human immunodeficiency virus-infected individuals, despite the widespread use of prophylaxis and the development of new chemotherapeutic agents. The study of P. carinii and of pulmonary host defenses directed against it has been limited
CD4+ T-helper-cell responses in mice with low-level Candida albicans infection.: Infect Immun. 1996 Dec;64(12):4907-14. Unique Identifier : AIDSLINE MED/97100998; Mencacci A; Spaccapelo R; Del Sero G; Enssle KH; Cassone A; Bistoni F; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; Resistance and susceptibility to Candida albicans infection have been shown to be dependent upon the activation of CD4+ T helper (Th) type 1 or Th2 cells, respectively. To study the type, kinetics, and cytokine dependency of CD4+ Th-cell responses in low-level C. albicans infection, susceptible mice were infected with
Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection.: Infect Immun. 1996 Dec;64(12):4976-83. Unique Identifier : AIDSLINE MED/97101008; Kelly KA; Robinson EA; Rank RG; Department of Microbiology and Immunology, University of Arkansas; for Medical Sciences, Little Rock 72205, USA.; kkelly@biomed.uams.edu; A Th1-type response develops following vaginal infection with the mouse pneumonitis biovar of Chlamydia trachomatis (MoPn). Since the type of response, i.e., Th1 versus Th2, can be influenced by factors present during T-cell activation, we examined the effects of different routes of MoPn administration on the cytokine
In utero exposure to Onchocerca volvulus: relationship to subsequent infection intensity and cellular immune responsiveness.: Infect Immun. 1996 Dec;64(12):5061-5. Unique Identifier : AIDSLINE MED/97101020; Elson LH; Days A; Calvopina M; Paredes W; Araujo E; Guderian RH; Bradley JE; Nutman TB; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, Bethesda, Maryland 20892, USA.; Afro-Ecuadorian individuals from an area where Onchocerca volvulus is hyperendemic have been monitored for infection over the past 16 years. To determine whether in utero exposure to O. volvulus biases a child s subsequent immune responses, children (9 to 16 years old) for whom the mother s infection status was known
Tumor necrosis factor-inducing activities of Cryptococcus neoformans components.: Infect Immun. 1996 Dec;64(12):5199-204. Unique Identifier : AIDSLINE MED/97101039; Delfino D; Cianci L; Migliardo M; Mancuso G; Cusumano V; Corradini C; Teti G; Istituto di Microbiologia, Facolta di Medicina e Chirurgia,; Universita degli Studi di Messina, Italy.; Cryptococcus neoformans-induced tumor necrosis factor alpha (TNF-alpha) production may lead to increased human immunodeficiency virus replication in patients with AIDS. In order to identify cryptococcal components that are predominantly responsible for stimulating TNF production, various concentrations of glucuronoxyl
In vivo alterations in cytokine production following interleukin-12 (IL-12) and anti-IL-4 antibody treatment of CB6F1 mice with chronic cutaneous leishmaniasis.: Infect Immun. 1996 Dec;64(12):5248-54. Unique Identifier : AIDSLINE MED/97101046; Li J; Scott P; Farrell JP; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia 19104, USA.; CB6F1 mice exhibit intermediate resistance to infection with Leishmania major compared to their highly susceptible (BALB/c) and resistant (C57BL/6) parental strains. Unlike the C57BL/6 and BALB/c strains, which rapidly develop dominant Th1- or Th2-type responses, respectively, after infection, CB6F1 mice develop respo
Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells.: Infect Immun. 1996 Dec;64(12):5295-301. Unique Identifier : AIDSLINE MED/97101053; Mahon BP; Ryan MS; Griffin F; Mills KH; Department of Biology, St. Patrick's College, Maynooth, County; Kildare, Ireland.; Using a murine respiratory infection model, we have demonstrated previously that infection with Bordetella pertussis or immunization with a whole-cell pertussis vaccine induced antigen-specific Th1 cells, which conferred a high level of protection against aerosol challenge. In contrast, immunization with an acellular
Giant molluscum contagiosum in AIDS.: Int J Dermatol. 1996 Jan;35(1):45-7. Unique Identifier : AIDSLINE MED/96436044; Vozmediano JM; Manrique A; Petraglia S; Romero MA; Nieto I; Hospital Universitario de Puerto Real, Cadiz, Spain.; A 31-year-old man, an intravenous drug user and in an advanced stage of acquired immune deficiency syndrome (AIDS), was admitted in our Department for the treatment of skin lesions that had been diagnosed as molluscum contagiosum (MC). The clinical examination revealed the presence of multiple nodular lesions, some of
Molecular epidemiologic analysis of Japanese patients with molluscum contagiosum.: Int J Dermatol. 1996 Feb;35(2):99-105. Unique Identifier : AIDSLINE MED/97002696; Yamashita H; Uemura T; Kawashima M; Department of Dermatology, Tokyo Women's Medical College, Japan.; BACKGROUND: Molluscum contagiosum virus (MCV) causes molluscum contagiosum (MC) in both children and adults. Recent studies have revealed that the DNA of MCV can be classified into two major types by restriction enzyme cleavage patterns; however, the relationship between MCV types and the clinical features has not bee
Mechanisms of inhibition of in vitro dimerization of HIV type I RNA by sense and antisense oligonucleotides.: J Biol Chem. 1996 Nov 15;271(46):28812-7. Unique Identifier : AIDSLINE MED/97067123; Skripkin E; Paillart JC; Marquet R; Blumenfeld M; Ehresmann B; Ehresmann C; Unite Propre de Recherche 9002 du CNRS, Institut de Biologie; Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084; Strasbourg-cedex, France. ehresmc@ibmc.u-strsbg.fr; Retroviruses display a strong selective pressure to maintain the dimeric nature of their genomic RNAs, suggesting that dimerization is essential for viral replication. Recently, we identified the cis-element required for initiation of human immunodeficiency virus type I (HIV-I) RNA dimerization in vitro. The dimerizat
Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.: J Biol Chem. 1996 Nov 29;271(48):30442-50. Unique Identifier : AIDSLINE MED/97094775; Decroly E; Wouters S; Di Bello C; Lazure C; Ruysschaert JM; Seidah NG; Laboratoire de Chimie Physique des Macromolecules aux; Interfaces, CP206/2, Universite libre de Bruxelles, 1050,; Brussels, Belgium.; The human immunodeficiency virus HIV envelope glycoprotein gp160 is synthesized as an inactive precursor, which is processed into its fusiogenic form gp120/gp41 by host cell proteinases during its intracellular trafficking. Kexin/subtilisin-related endoproteases have been proposed to be enzyme candidates for this matu
Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase.: J Biol Chem. 1996 Nov 29;271(48):30864-9. Unique Identifier : AIDSLINE MED/97094836; Kumar S; Orsini MJ; Lee JC; McDonnell PC; Debouck C; Young PR; Department of Molecular Immunology, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.; The human immunodeficiency virus, type 1 (HIV-1) promoter is known to be activated by proinflammatory cytokines and UV light. These stimuli also activate various members of the mitogen-activated protein kinase family, including JNK/SAPK and CSBP/p38. In HeLa cells containing an integrated HIV-1 long terminal repeat (L
Serum leptin levels in the acquired immunodeficiency syndrome.: J Clin Endocrinol Metab. 1996 Dec;81(12):4342-6. Unique Identifier : AIDSLINE MED/97112359; Grunfeld C; Pang M; Shigenaga JK; Jensen P; Lallone R; Friedman J; Feingold KR; Department of Medicine, University of California, San Francisco,; USA.; Leptin, a hormone that is secreted by adipose tissue in proportion to fat stores, regulates energy balance and appetite. Recently, tumor necrosis factor and interleukin-1, cytokines that regulate the host response to infection, have been shown to acutely increase leptin levels, raising the possibility that leptin coul
Apoptosis induced by HIV-1 infection of the central nervous system.: J Clin Invest. 1996 Nov 1;98(9):1979-90. Unique Identifier : AIDSLINE MED/97060281; Shi B; De Girolami U; He J; Wang S; Lorenzo A; Busciglio J; Gabuzda D; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Apoptosis plays a role in AIDS pathogenesis in the immune system, but its role in HIV-1-induced neurological disease is unknown. In this study, we examine apoptosis induced by HIV-1 infection of the central nervous system (CNS) in an in vitro model and in brain tissue from AIDS patients. HIV-1 infection of primary bra
Oral hairy leukoplakia in 71 HIV-seropositive patients: clinical symptoms, relation to immunologic status, and prognostic significance.: J Am Acad Dermatol. 1996 Dec;35(6):928-34. Unique Identifier : AIDSLINE MED/97119129; Husak R; Garbe C; Orfanos CE; Department of Dermatology, University Medical Center Benjamin; Franklin, Free University of Berlin, Germany.; BACKGROUND: Oral hairy leukoplakia (OHL) is a benign hyperplasia of the oral mucosa that is induced by Epstein-Barr virus. It occurs nearly exclusively in men infected with HIV. OHL is a marker of moderate to advanced immunodeficiency and disease progression in patients with HIV infection. OBJECTIVE: We attempted to d
Operative precautions in HIV and other bloodborne virus diseases.: Infect Control Hosp Epidemiol. 1996 Aug;17(8):529-31. Unique Identifier : AIDSLINE MED/97029286; Raahave D; Department of Organ Surgery, Oresund Hospital,; Helsingor/Horsholm, Denmark.; Mathematical means have suggested that the surgical team is at particular risk of acquiring HIV (or other bloodborne viruses) from a source patient. To reduce this risk, it is mandatory to avoid accidental injuries during operative procedures. The surgeon must handle tissues with instruments and must minimize finger u
AIDS, emergency operations, and infection control.: Infect Control Hosp Epidemiol. 1996 Aug;17(8):532-8. Unique Identifier : AIDSLINE MED/97029287; Wittmann MM; Wittmann A; Wittmann DH; Department of Surgery, University of Colorado Health Center,; Denver, USA.; Acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV) may turn out to be the largest lethal epidemic of infection ever. The estimated global number of HIV-infected adults in 1993 was 13 million, with projections of up to 40 million by the year 2000. Human immunodeficiency virus inf
Herpes virus saimiri transformation of T cells in CD3 gamma immunodeficiency: phenotypic and functional characterization.: J Immunol Methods. 1996 Nov 13;198(2):177-86. Unique Identifier : AIDSLINE MED/97101487; Rodriguez-Gallego C; Corell A; Pacheco A; Timon M; Regueiro JR; Allende LM; Madrono A; Arnaiz-Villena A; Department of Immunology, Hospital Universitario 12 de Octubre,; Madrid, Spain.; The characterization of T cell immunodeficiencies could in part be supported by using stable cell lines in which biochemical and molecular studies of the defect could be carried out thereby omitting frequent bleeding of patients. First attempts to obtain such cell lines included HTLV-I transformation and exogenous
A simple and rapid method for removal of specific cell populations from whole blood.: J Immunol Methods. 1996 Nov 13;198(2):199-202. Unique Identifier : AIDSLINE MED/97101489; Zwerner RK; Schmittling RJ; Russell TR; Coulter Corporation, Miami, FL 33196-2500, USA.; A method is presented in which specific cells can be rapidly separated from whole blood by the use of antibody labelled dense particles utilizing gravity as a means of separation. This method specifically removes the targeted cells with minimal non-specific cell loss. The method is simple to perform and rapid, requiri
Analysis of live, oral poliovirus vaccine monopools for human immunodeficiency virus type 1 and simian immunodeficiency virus.: J Infect Dis. 1996 Dec;174(6):1185-90. Unique Identifier : AIDSLINE MED/97094119; Khan AS; Shahabuddin M; Bryan T; Joshi BH; Lee S; Hewlett IK; Laboratory of Retrovirus Research, Center for Biologics; Evaluation and Research, US Food and Drug Administration,; Bethesda, Maryland, USA.; Although there is no evidence for transmission of mammalian retroviruses to humans via vaccine immunization, the allegations of contamination of oral poliovirus vaccines with human immunodeficiency virus (HIV) type 1 or a hypothetical progenitor virus from monkeys has created controversy and dispute regarding the orig
Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine.: J Infect Dis. 1996 Dec;174(6):1191-9. Unique Identifier : AIDSLINE MED/97094120; Brichacek B; Swindells S; Janoff EN; Pirruccello S; Stevenson M; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha, USA.; Primary factors that influence virus burden during human immunodeficiency virus type 1 (HIV-1) disease progression remain a fundamental issue in pathogenesis. Because pneumococcal vaccine is routinely given to HIV-1-infected patients and replication of HIV-1 within CD4 T cells is dependent on the activation state of t
Evaluation of human immunodeficiency virus (HIV) type 1 RNA levels in cerebrospinal fluid and viral resistance to zidovudine in children with HIV encephalopathy.: J Infect Dis. 1996 Dec;174(6):1200-6. Unique Identifier : AIDSLINE MED/97094121; Sei S; Stewart SK; Farley M; Mueller BU; Lane JR; Robb ML; Brouwers P; Pizzo PA; Division of Clinical Sciences, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892-1928, USA.; The amount of human immunodeficiency virus (HIV) type 1 RNA and the presence of a codon 215 mutation indicative of zidovudine resistance were evaluated in cerebrospinal fluid (CSF) and plasma obtained from HIV-1-infected children. The level of HIV-1 RNA in CSF was highest in children with severe encephalopathy (n = 25
After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmission Study Group.: J Infect Dis. 1996 Dec;174(6):1207-11. Unique Identifier : AIDSLINE MED/97094122; Cooper ER; Nugent RP; Diaz C; Pitt J; Hanson C; Kalish LA; Mendez H; Zorrilla C; Hershow R; Moye J; Smeriglio V; Fowler MG; Boston City Hospital/Boston University School of Medicine,; Massachusetts 02118, USA.; To determine the impact of the AIDS Clinical Trials Group (ACTG) Protocol 076 results on the subsequent use of zidovudine during pregnancy and the transmission rate of human immunodeficiency virus (HIV) in a cohort of mother-infant pairs (Women and Infants Transmission Study), a retrospective analysis was done. Transm
Protection from Mycobacterium avium complex disease in human immunodeficiency virus-infected persons with a history of tuberculosis.: J Infect Dis. 1996 Dec;174(6):1212-7. Unique Identifier : AIDSLINE MED/97094123; Horsburgh CR Jr; Hanson DL; Jones JL; Thompson SE 3rd; Department of Medicine, Emory University School of Medicine,; Grady Memorial Hospital, Atlanta, Georgia 30303, USA.; Risk of Mycobacterium avium complex disease was examined in human immunodeficiency virus (HIV)-infected patients with and without a history of tuberculosis. Information was obtained by retrospective review of charts of patients in HIV clinics in 10 US cities. Among 1363 patients with
Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response.: J Infect Dis. 1996 Dec;174(6):1303-8. Unique Identifier : AIDSLINE MED/97094134; Brown JA; Titus RG; Nabavi N; Glimcher LH; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; The costimulatory molecules CD80 and CD86 affect the differentiation of Th1 and Th2 subsets in experimental allergic encephalomyelitis, an autoimmune disorder. It is reported that the CD86 costimulator significantly affects disease outcome in Leishmania major infection, a classic model of Th subset polarization. Treat
Detection of the hepatitis G virus genome among injecting drug users, homosexual and bisexual men, and blood donors.: J Infect Dis. 1996 Dec;174(6):1320-3. Unique Identifier : AIDSLINE MED/97094137; Stark K; Bienzle U; Hess G; Engel AM; Hegenscheid B; Schluter V; Institute of Tropical Medicine, Department of Medical Statistics; and Clinical Epidemiology, Free University, Berlin, Germany.; The recently identified hepatitis G virus (HGV) is parenterally transmitted; the impact of sexual transmission is unknown. Moreover, it is unclear what proportion of HGV-infected persons may develop persistent viremia. Sera from injecting drug users (IDUs), non-drug-injecting homosexual and bisexual men with high leve
The effect of influenza vaccination on human immunodeficiency virus type 1 load: a randomized, double-blind, placebo-controlled study.: J Infect Dis. 1996 Dec;174(6):1332-6. Unique Identifier : AIDSLINE MED/97094140; Glesby MJ; Hoover DR; Farzadegan H; Margolick JB; Saah AJ; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; To determine if vaccination induces replication of human immunodeficiency virus type 1 (HIV-1), 42 HIV-1-infected subjects with CD4 cell counts of 200-500 cells/microL were randomized to receive influenza vaccine or saline placebo. Infectious cell-associated and plasma HIV-1 RNA virus load were measured twice at basel
Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis.: J Nat Prod. 1996 Jan;59(1):83-7. Unique Identifier : AIDSLINE MED/96275159; Hayashi T; Hayashi K; Maeda M; Kojima I; Faculty of Pharmaceutical Sciences and School of Medicine, Toyama; Medical and Pharmaceutical University, Toyama, Japan.; Bioactivity-directed fractionation of a hot H2O extract from a blue-green alga Spirulina platensis led to the isolation of a novel sulfated polysaccharide named calcium spirulan (Ca-SP) as an antiviral principle. This polysaccharide was composed of rhamnose, ribose, mannose, fructose, galactose, xylose, glucose, glucu
Enhanced malignant progression of nasopharyngeal carcinoma cells mediated by the expression of Epstein-Barr nuclear antigen 1 in vivo.: J Pathol. 1996 Nov;180(3):243-8. Unique Identifier : AIDSLINE MED/97117915; Sheu LF; Chen A; Meng CL; Ho KC; Lee WH; Leu FJ; Chao CF; Department of Pathology, Tri-Service General Hospital, National; Defence Medical Centre, Taipei, Taiwan, Republic of China.; Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV) and mostly classified as poorly differentiated squamous cell carcinoma or undifferentiated carcinoma with early metastasis and a rapidly progressive clinical course. The EBV-encoded latent proteins, Epstein-Barr nuclear antigen 1 (
Immunity to Haemophilus influenzae type b polysaccharide capsule after vaccination with the complete series of oligosaccharide CRM197 conjugate vaccine in infants with human immunodeficiency virus infection.: J Pediatr. 1996 Mar;128(3):363-5. Unique Identifier : AIDSLINE MED/96370609; Peters VB; Sood SK; Department of Pediatrics, Mount Sinai School of Medicine, New; York, New York 10029, USA.; We evaluated immunity to Haemophilus influenzae type b (Hib) in 18 human immunodeficiency virus-infected infants who were vaccinated with a complete series of Hib conjugate vaccine. Four months after the primary series, the geometric mean anticapsular antibody concentration in 11 children was 0.40 microgram/ml. There
Maternal-fetal pharmacokinetics of zidovudine in rats.: J Pharm Sci. 1996 Sep;85(9):965-70. Unique Identifier : AIDSLINE MED/97031982; Huang CS; Boudinot FD; Feldman S; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602-2351, USA.; The disposition of zidovudine ( AZT ) was investigated in near-term (day 20) pregnant rats after intravenous bolus administration of AZT at 50 mg/kg. A compartmental pharmacokinetic model was developed to describe AZT concentrations in maternal plasma (
First-trimester spontaneous abortions and the incidence of human immunodeficiency virus seropositivity.: J Reprod Med. 1996 Jan;41(1):15-8. Unique Identifier : AIDSLINE MED/97007812; Bakas C; Zarou DM; de Caprariis PJ; Department of Obstetrics and Gynecology, Lutheran Medical Center,; Brooklyn, New York, USA.; OBJECTIVE: To examine the human immunodeficiency virus (HIV) seropositivity rates and HIV risk factors in women with a confirmed diagnosis of first-trimester spontaneous abortion in a community hospital. STUDY DESIGN: Patients admitted with confirmed diagnoses of spontaneous incomplete first-trimester abortions at Lut
The rising incidence of tuberculosis.: J R Soc Med. 1996 Sep;89(9):497-500. Unique Identifier : AIDSLINE MED/97106769; Millard FJ; St George's Hospital, London, England.
PCR detection of Toxoplasma gondii DNA in CSF for the differential diagnosis of AIDS-related focal brain lesions.: J Med Microbiol. 1996 Dec;45(6):472-6. Unique Identifier : AIDSLINE MED/97117183; Cingolani A; De Luca A; Ammassari A; Murri R; Linzalone A; Grillo R; Antinori A; Department of Infectious Diseases, Catholic University, Rome,; Italy.; To evaluate whether the detection of Toxoplasma gondii DNA in CSF could contribute to the differential diagnosis of AIDS-related focal brain lesions, CSF samples from 88 HIV-infected patients (56 with focal brain lesions and 32 without) were tested prospectively by a nested PCR for the B1 gene of T. gondii. The assay
Examination of TAR-independent Trans activation by human immunodeficiency virus type 1 Tat in human glial cells.: J Neurosci Res. 1996 Mar 15;43(6):652-66. Unique Identifier : AIDSLINE MED/96259028; Kim YS; Panganiban AT; Institute of Cancer Research, College of Medicine, Yonsei; University, Seoul, Korea.; Astrocytic glial cells derived from central nervous system (CNS) can support human immunodeficiency virus type 1 (HIV-1) replication in cell culture, may be infected in tissue culture, and are thought to be a large HIV-1 reservoir in vivo. The Tat protein of HIV-1 interacts with a cis-acting target sequence referred t
Lack of evidence of HIV-2 infection among multitransfused thalassemic children in the city of New Delhi [letter]: J Trop Pediatr. 1996 Apr;42(2):116-7. Unique Identifier : AIDSLINE MED/97105338; Chattopadhya D; Aggarwal R; Kumari SS; Verghese T; Sen S
Aspergillus fumigatus specific antibodies in multitransfused children with human immunodeficiency virus (HIV) infection in relation to serum levels of Interleukin-2, gamma Interferon and tumour necrosis factor.: J Trop Pediatr. 1996 Apr;42(2):85-90. Unique Identifier : AIDSLINE MED/97105330; Bhatnagar PK; Chattopadhya D; Sharma GL; Madan T; Sarma PU; Centre for Biochemical Technology, Delhi, India.; Anti-Aspergillus fumigatus antibodies (IgG and IgE class) and serum levels of cytokines (gamma Interferon, Interleukin-2 and tumour necrosis factor-alpha) were studied in multitransfused (MT) children in relation to human immunodeficiency virus (HIV) infection. The specific antibodies to Aspergillus fumigatus were pre
Risk of symptomatic central venous thrombotic complications in AIDS patients receiving home parenteral nutrition.: JPEN J Parenter Enteral Nutr. 1996 Jul-Aug;20(4):302-5. Unique Identifier : AIDSLINE MED/97018498; Duerksen DR; Ahmad A; Doweiko J; Bistrian BR; Mascioli EA; Department of Medicine, Deaconess Hospital, Boston,; Massachusetts, USA.; BACKGROUND: The acquired immunodeficiency syndrome (AIDS) is frequently complicated by malnutrition that may require parenteral nutritional support. In a non-AIDS population with long-term indwelling central venous catheters, low-dose warfarin therapy has been shown to prevent venous thrombosis. The purpose of this st
[The changes in lymphocytes subpopulations of a patient with postoperative chylothorax]: Kyobu Geka. 1996 Dec;49(13):1085-7. Unique Identifier : AIDSLINE MED/97117734; Yamaguchi T; Watanabe G; Kotoh K; Yamashita A; Sugiyama S; Misaki T; First Department of Surgery, Toyama Medical and Pharmaceutical; University, Japan.; A case of 64-year-old male who developed chylorrhea at 2 days post coronary artery by-pass grafting, is reported. He was managed conservatively for 3 weeks. But chylothorax was not improved, he was treated operatively. Analysis of his lymphocyte subpopulations in peripheral blood were performed during the course of ch
[Resistant tuberculosis in Madrid. Coinfection of tuberculosis and AIDS (letter)]: Med Clin (Barc). 1996 Sep 21;107(9):357-8. Unique Identifier : AIDSLINE MED/97073308; de March Ayuela P
[Resistant tuberculosis in Madrid. Coinfection of tuberculosis and AIDS (letter)]: Med Clin (Barc). 1996 Sep 21;107(9):358-9. Unique Identifier : AIDSLINE MED/97073309; Garcia Rodriguez J; Lorenzo Garcia MV
Bioinformatics speeds HIV-1 drug development [news]: Lancet. 1996 Dec 14;348(9042):1648. Unique Identifier : AIDSLINE MED/97121331; Fishman RH
Focal tuberculosis of the liver with local hemorrhage in a patient with acquired immunodeficiency syndrome.: Liver. 1996 Jun;16(3):218-20. Unique Identifier : AIDSLINE MED/97026833; Brmbolic BJ; Boricic I; Salemovic DR; Jevtovic DL; Ranin JT; Begic-Janeva A; Institute for Infectious and Tropical Disease Dr Kosta Todorovic,; Medical Faculty, Belgrade, Yugoslavia.; Tuberculosis of the liver is common in patients with acquired immunodeficiency syndrome (AIDS). Tuberculous liver granulomas in such patients are usually atypical. The liver granulomas may be even totally absent, but liver tissue usually reveals numerous acid-fast bacilli. Focal tuberculosis of the liver is a less com
Evaluation of enzyme-linked immunosorbent assay for the serodiagnosis of tuberculosis in patients with AIDS in Cuba.: Mem Inst Oswaldo Cruz. 1996 Mar-Apr;91(2):191. Unique Identifier : AIDSLINE MED/96318404; Montoro E; Diaz R; Echemendia M; Valdivia JA; Laboratorio Nacional de Referencia de Mycobacteria y; Tuberculosis, Instituto de Medicina Tropical Pedro Kouri, (IPK),; Cuba.
[Post-exposure drug prevention of HIV infection]: Med Klin. 1996 Sep 15;91(9):589-99. Unique Identifier : AIDSLINE MED/97028135; Rave K; Jablonowski H; Ross B; Philipp T; Zentrum fur Innere Medizin, Universitirsklinikum Essen.
Energy expenditure in human immunodeficiency virus infection [letter]: N Engl J Med. 1997 Jan 2;336(1):70-1. Unique Identifier : AIDSLINE MED/97122474; Mulligan K; Tai VW; Schambelan M
Spread of HIV gains pace [news]: Nature. 1996 Dec 5;384(6608):399. Unique Identifier : AIDSLINE MED/97100925
US drops patent claim to Hagahai cell line [news]: Nature. 1996 Dec 12;384(6609):500. Unique Identifier : AIDSLINE MED/97113396; Lehrman S
Host factors and the pathogenesis of HIV-induced disease.: Nature. 1996 Dec 12;384(6609):529-34. Unique Identifier : AIDSLINE MED/97113407; Fauci AS; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892, USA.; The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understand
Canada's HIV blood inquiry turns poisonous [news]: Nature. 1996 Dec 19-26;384(6610):602. Unique Identifier : AIDSLINE MED/97122321; Spurgeon D
Advances encourage Nobel winner to head AIDS vaccine effort [news]: Nature. 1996 Dec 19-26;384(6610):604. Unique Identifier : AIDSLINE MED/97122323; Wadman M
Priorities for AIDS research set out by US task force [news]: Nature. 1996 Dec 19-26;384(6610):606. Unique Identifier : AIDSLINE MED/97122324
[Drug resistance in Mycobacterium tuberculosis in The Netherlands]: Ned Tijdschr Geneeskd. 1996 Nov 2;140(44):2187-91. Unique Identifier : AIDSLINE MED/97085178; Lambregts-van Weezenbeek CS; van Klingeren B; Veen J; Koninklijke Nederlandse Centrale Vereniging tot bestrijding der; Tuberculose, Den Haag.; OBJECTIVE: To determine magnitude, trend and specific features of the resistance problem. DESIGN: Descriptive. SETTING: Royal Netherlands Tuberculosis Association, The Hague, the Netherlands. METHODS: The data of the National Institute of Public Health and Environmental Protec
[Transmission of multiresistant tuberculosis in a Dutch hospital]: Ned Tijdschr Geneeskd. 1996 Nov 16;140(46):2293-5. Unique Identifier : AIDSLINE MED/97117754; Lambregts-van Weezenbeek CS; Keizer ST; Sebek MM; Schepp-Beelen JC; van der Loo CJ; Koninklijke Nederlandse Centrale Vereniging tot bestrijding der; Tuberculose, Den Haag.; Nosocomial transmission of multiresistant tuberculosis in the Netherlands is described for the first time in this article. It was detected by systematic country-wide DNA-fingerprinting. By the time the contact case (a man aged 35) developed disease he was residing in another p
[Results of screening for HIV antibodies in pregnant women in Amsterdam reference stations, 1988-1995]: Ned Tijdschr Geneeskd. 1996 Nov 16;140(46):2296-8. Unique Identifier : AIDSLINE MED/97117755; Bindels PJ; Mulder-Folkerts DK; Schutte MF; Smit-van Wijk I; Boer K; Coutinho RA; Gemeentelijke Geneeskundige en Gezondheidsdienst, sector; Volksge-zondheid en Milieu, Amsterdam.; In order to determine the prevalence of HIV in the general heterosexual population of Amsterdam, 16,709 pregnant women attending two hospitals and one maternity clinic in the period 1988-1995 were asked to undergo a HIV test, of whom 15,276 gave informed consent (91.4%). Pregnant women with a risk of HIV infection wer
The U.S. Army HIV testing program: the first decade.: Mil Med. 1996 Feb;161(2):117-22. Unique Identifier : AIDSLINE MED/97010166; Brown AE; Brundage JF; Tomlinson JP; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD 20850, USA.; In response to the human immunodeficiency virus (HIV) epidemic, the U.S. military established comprehensive policies to protect individual and public health and to assure military readiness. Central to this effort was the creation of a total-force HIV screening program. As representative of these military programs, th
Prevention and treatment of HIV infections in minorities in the US military: a review of military research.: Mil Med. 1996 Feb;161(2):123-7. Unique Identifier : AIDSLINE MED/97010167; Brown AE; Newby JH; Ray KL; Jackson JN; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD 20850, USA.; The prevalence and incidence of HIV-1 infection in the U.S. military has been higher in minorities than in whites. In order to understand the reason for this disproportionate impact of the epidemic, military HIV research efforts were reviewed for race/ethnic-specific differences in a conference held in July 1993. Stud
Pyramidal neurones in pathological human motor cortex express nitric oxide synthase.: Neurosci Lett. 1996 Jul 19;212(3):187-90. Unique Identifier : AIDSLINE MED/96440793; Wallace MN; Tayebjee MH; Rana FS; Farquhar DA; Nyong'o AO; Department of Biomedical Sciences, Marischal College, University; of Aberdeen, UK.; The enzyme nicotinamide adenine dinucleotide phosphate diaphorase (NADPH diaphorase) is widely used as a sensitive marker for indicating the presence of nitric oxide synthase in neurones. Pyramidal neurones in the healthy neocortex do not contain detectable levels of nitric oxide synthase. However, in the precentral g
Dental offices open to the public [news]: N Y State Dent J. 1996 Nov;62(9):67. Unique Identifier : AIDSLINE MED/97128523
Workplace AIDS/HIV: are you immune?: Occup Health Saf. 1996 Apr;65(4):39-40. Unique Identifier : AIDSLINE MED/97010230; Oswald E; Near North National Group, Chicago, Illinois, USA.
T-cell lymphomas in v-Myb transgenic mice.: Oncogene. 1996 Nov 21;13(10):2205-12. Unique Identifier : AIDSLINE MED/97108667; Badiani PA; Kioussis D; Swirsky DM; Lampert IA; Weston K; CRC Centre for Cell and Molecular Biology, Institute of Cancer; Research, London, UK.; v-Myb, the transforming protein of avian myeloblastosis virus, causes acute myeloid leukemia in chickens. Similarly, truncation and rearrangement of the c-myb proto-oncogene to yield a v-Myb-like protein leads to myeloid and B cell lymphomas in chickens and mice, and may be a factor in a number of human cancers. To st
Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro.: Oncogene. 1996 Nov 21;13(10):2281-5. Unique Identifier : AIDSLINE MED/97108675; Baier-Bitterlich G; Baier G; Fuchs D; Bock G; Hausen A; Utermann G; Pavelka M; Wachter H; Institute for Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.; Adult T-cell leukemia is associated with high levels of neopterin, released in large amounts from human macrophages upon stimulation with interferon-gamma. Recent data suggested a potential role of neopterin-derivatives in oxygen radical-mediated processes, and evidence accumulates that oxidative stress is involved in
AIDS and the eye.: Pa Med. 1996 Mar;99 Suppl:88-93. Unique Identifier : AIDSLINE MED/97020625; Eller AW; Warren BB; Conti ER; Rubin TM; Ophthalmology, Eye and Ear Institute, University of Pittsburgh; School of Medicine, USA.; The AIDS pandemic has finally emerged from the big cities to the small towns of this country, as patients with this disease are returning home to spend their last months and days in the care of their families. No physician will be spared from caring for patients with AIDS. This multisystem disease crosses the boundari
Parvovirus B19 in HIV infection: a treatable cause of anemia.: Pathology. 1996 Aug;28(3):277-80. Unique Identifier : AIDSLINE MED/97069210; Fuller A; Moaven L; Spelman D; Spicer WJ; Wraight H; Curtis D; Leydon J; Doultree J; Locarnini S; Department of Microbiology and Infectious Diseases, Alfred; Hospital, Melbourne, Vic.; We describe the case of an adult male patient with AIDS who presented with severe anemia and on investigation was found to have red cell aplasia due to parvovirus B19 infection. Bone marrow examination revealed absence of erythroid development and rare giant pronormoblasts. Repeated serological examinations revealed a
Annual summary of vital statistics--1995.: Pediatrics. 1996 Dec;98(6 Pt 1):1007-19. Unique Identifier : AIDSLINE MED/97108968; Guyer B; Strobino DM; Ventura SJ; MacDorman M; Martin JA; Department of Maternal and Child Health, Johns Hopkins School of; Hygiene and Public Health, Baltimore, Maryland 21205, USA.; Recent trends in the vital statistics of the United States continued in 1995, including decreases in the number of births, the birth rate, the age-adjusted death rate, and the infant mortality rate; life expectancy at birth increased to a level equal to the record high of 75.8 years in
Neurologic status of human immunodeficiency virus 1-infected infants and their controls: a prospective study from birth to 2 years. Mothers and Infants Cohort Study.: Pediatrics. 1996 Dec;98(6 Pt 1):1109-18. Unique Identifier : AIDSLINE MED/97108981; Belman AL; Muenz LR; Marcus JC; Goedert JJ; Landesman S; Rubinstein A; Goodwin S; Durako S; Willoughby A; Department of Neurology, State University of New York Health; Sciences Center at Stony Brook 11794, USA.; OBJECTIVE: To determine the timing, extent, severity, and persistence of neurologic abnormalities in children with perinatally acquired human immunodeficiency virus 1 (HIV-1) infection compared with similar uninfected children of HIV-1-infected women and control children. METHODS: Serial neurologic examinations and he
Nursing management of symptoms influenced by HIV infection of the endocrine system.: Nurs Clin North Am. 1996 Dec;31(4):845-65. Unique Identifier : AIDSLINE MED/97124030; Briggs JM; Beazlie LH; Department of Medicine, Cleveland Veterans Affairs Medical; Center, Ohio, USA.; Examining the impact of endocrine disregulation is useful in managing symptoms of HIV infection in its later stages. Current studies indicate insults to the endocrine system from a variety of agents present in HIV infection. Establishing direct pathologic, causal effects is difficult; however, the functional domains o
Acute renal failure due to sulphadiazine crystalluria in AIDS patients.: Postgrad Med J. 1996 Sep;72(851):557-8. Unique Identifier : AIDSLINE MED/97106847; de Sequera P; Albalate M; Hernandez J; Vazquez A; Abad J; Ramiro E; Fernandez Guerrero M; Caramelo C; Casado S; Ortiz A; Nephrology Service, Fundacion Jimenez Diaz, Madrid, Spain.; We report two AIDS patients who developed acute renal failure while receiving sulphadiazine for cerebral toxoplasmosis. Renal ultrasound revealed diffuse bilateral echogenic shadowing material. Sheaves of wheat crystals, typical of sulphadiazine crystalluria, were present in the urine. One patient required a percuta
Deafness and blindness in a HIV-positive patient with cryptococcal meningitis [letter]: Postgrad Med J. 1996 Sep;72(851):575. Unique Identifier : AIDSLINE MED/97106855; Prada JL; Torre-Cisneros J; Kindelan JM; Jurado R; Villanueva JL; Navarro M; Linares MJ
[Seroprevalence of viral hepatitis A in France in homosexuals and intravenous drug users]: Presse Med. 1996 Sep 7;25(25):1141-3. Unique Identifier : AIDSLINE MED/97106857; Lucht F; Berthelot P; Job P; Bonnevial L; Digonnet C; Fresard A; Chabert B; Cabal C; Pozzetto B; Service des Maladies infectieuses et tropicales, CHU de; Saint-Etienne.; OBJECTIVES: In industrialized countries with a high level of sanitation, immunity against hepatitis A (HVA) is not acquired during childhood, and infection typically occurs in adults, mainly in travelers returning from developing countries where infection is endemic. However, the introduction of hepatitis A virus (HAV
[Comparative profitability of hepatic biopsy and microbiological tests in patients with HIV infection]: Presse Med. 1996 Sep 7;25(25):1147-51. Unique Identifier : AIDSLINE MED/97106859; Roger PM; Carles M; Saint-Paul MC; Taillan B; Mondain V; Michiels JF; Fuzibet JG; Dujardin P; Dellamonica P; Service des Maladies infectieuses et tropicales, Hopital de; l'Archet, Nice.; OBJECTIVES: Diagnostic liver biopsy is proposed in HIV-positive patients who present unexplained fever. This invasive procedure is truly useful if it allows establishing a difficult diagnosis or improves survival rate. We conducted a retrospective study to determine the diagnostic and prognostic power of liver biopsy
[Generalized rhodococcosis of fatal outcome in a patient with AIDS (letter)]: Presse Med. 1996 Sep 7;25(25):1166. Unique Identifier : AIDSLINE MED/97106864; Steineur MP; Chaumentin G; Zenone T; Boibieux A; Peyramond D; Bertrand JL
Prevalence of Isospora belli in AIDS and immunocompetent patients in Uganda [letter]: Presse Med. 1996 Sep 7;25(25):1170. Unique Identifier : AIDSLINE MED/97106871; Ravera M; Reggiori A; Riccioni G
[Epstein-Barr virus cerebellitis in a patient with human immunodeficiency virus infection. Occurrence of EBV Hodgkin's disease at 2 years (letter)]: Presse Med. 1996 Sep 14;25(26):1215. Unique Identifier : AIDSLINE MED/97106883; Pulik M; Lionnet F; Gaulier A; Genet P; Petitdidier C; Rozenberg F
[HIV: easier transmission through oral contact?]: Pharm Unserer Zeit. 1996 Sep;25(5):285. Unique Identifier : AIDSLINE MED/97080259
Year 2000 health status indicators: a profile of California.: Public Health Rep. 1996 Nov-Dec;111(6):521-6. Unique Identifier : AIDSLINE MED/97113859; Sutocky JW; Dumbauld S; Abbott GB; Center for Health Statistics, Department of Health Services,; State of California, Sacramento 95814, USA.; jsutocky@bw1.cahwnet.gov; OBJECTIVES: To examine the health status of Californians using a set of 18 health status indicators (HSIs) corresponding to goals set forth in Healthy People 2000 and to develop a health status profile for use in research and surveillance, policy development program planning, and program evaluation. METHODS: Federal,
Emerging drug targets in the molecular pathogenesis of asthma.: Prog Drug Res. 1996;47:165-210. Unique Identifier : AIDSLINE MED/97121100; Jucker JF; Anderson GP; CIBA, Basel, Switzerland.
Predictors of Staphylococcus aureus pneumonia associated with human immunodeficiency virus infection.: Respir Med. 1996 Oct;90(9):531-7. Unique Identifier : AIDSLINE MED/97105147; Tumbarello M; Tacconelli E; Lucia MB; Cauda R; Ortona L; Department of Infectious Diseases, Catholic University, Rome,; Italy.; This study is based on a retrospective logistic regression analysis of all human immunodeficiency virus (HIV)-infected patients with Staphylococcus aureus pneumonia (SAP) admitted to the Department of Infectious Diseases, Catholic University, Rome, Italy between January 1986 and Dec
[Eustachian valve endocarditis produced by Staphylococcus hominis in a patient with HIV infection (letter)]: Rev Clin Esp. 1996 Aug;196(8):572-3. Unique Identifier : AIDSLINE MED/96428126; Navarro V; Martinez-Alfaro E; Sanz P; Solera J
[Primary prevention actions in AIDS and sexually transmitted diseases in adolescents]: Rev Fac Cien Med Univ Nac Cordoba. 1995;53 Suppl:55-63. Unique Identifier : AIDSLINE MED/96342721; Barron de Carbonetti M; Zurlo de Mirotti SM; Carbonetti ME; Lesa ME; Mercado P; Alvarez Maldonado A; Catedra de Biologia del Crecimiento y Desarrollo. Escela de C. de; la Educacion. Fac. de Filosofia y Humanidades. UNC.; Considering primary prevention of ETS a priority in Adolescent Health care, we decided to investigate knowledge and attitudes of 205 students in relation to these pathologies. Results were used to organize an educational proposal based on groupal training of ``Youth Health Promotors . It is also shown the necessity o
[How did the AIDS virus develop? Scientific knowledge and philosophical suppositions]: Schweiz Rundsch Med Prax. 1996 Nov 12;85(46):1473-5. Unique Identifier : AIDSLINE MED/97102353; Stahl H; FMH fur Allgemeine Medizin, Heerbrugg.; Several years after the occurrence of the first cases of AIDS, the HIV retrovirus was discovered in the eighties. How did this terrible virus come into being? A punishment from God say some. A new life form created by man using gene technology , say others. Most scientists, however, do not share these views. They a
[A case from practice (361). Acute pancreatitis in AIDS. idiopathic. In microscopic gallstones. (Cotrimoxazole-induced). (In cryptosporidiosis)]: Schweiz Rundsch Med Prax. 1996 Nov 12;85(46):1493-4. Unique Identifier : AIDSLINE MED/97102357; Bassetti S; Medizinische Universitatspoliklinik, Kantonsspital Basel.
The spectrum of African Kaposi's sarcoma: is it consequential upon diverse immunological responses?: Scand J Infect Dis. 1996;28(3):225-30. Unique Identifier : AIDSLINE MED/97016724; Matondo P; Zumla A; Department of Medicine, School of Medicine, University of Zambia,; Lusaka, Zambia.; Kaposi s sarcoma (KS) is a complex, multicellular growth, the pathogenesis of which remains unclear. Endemic African Kaposi s Sarcoma (KS) is characterized by its epidemiological peculiarities, protean clinical manifestations and an unpredictable natural history. A wide spectrum of clinical manifestations occurs, alth
Assessments of plasma HIV RNA and CD4 cell counts after combined Pneumovax and tetanus toxoid vaccination: no detectable increase in HIV replication 6 weeks after immunization.: Scand J Infect Dis. 1996;28(3):239-41. Unique Identifier : AIDSLINE MED/97016727; Katzenstein TL; Gerstoft J; Nielsen H; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; The influence of simultaneous vaccination with Pneumovax and tetanus toxoid on plasma human immunodeficiency virus (HIV) RNA and CD4 cell counts was assessed in patients with HIV infection. Six weeks after immunization plasma HIV RNA did not differ significantly from baseline values. A slight decline in CD4 cell count
Invasive Candida norvegensis infection in immunocompromised patients.: Scand J Infect Dis. 1996;28(3):311-2. Unique Identifier : AIDSLINE MED/97016743; Nielsen H; Stenderup J; Department of Infectious Diseases, National University Hospital; (Rigshospitalet), Copenhagen, Denmark.; Invasive infection with Candida norvegensis has previously been reported only once. Three new cases of invasive infection with C. norvegensis are described. One patient with acute myeloid leukaemia and neutropenic septicaemia had positive blood cultures with C. norvegensis, and 2 patients with AIDS and prolonged unexp
Recurrent bilateral anterior uveitis with hypopyon and rifabutin therapy.: Scand J Infect Dis. 1996;28(3):325-6. Unique Identifier : AIDSLINE MED/97016747; Zenone T; Boibieux A; Fleury J; Chaumentin G; Daoud F; Burgat C; Peyramond D; Bertrand JL; Service of Infectious and Tropical Disease, Hopital de la; Croix-Rousse, Lyon, France.; Rifabutin is used in patients with human immunodeficiency virus infection to prevent and treat Mycobacterium avium complex infection. We report a case of recurrent bilateral anterior uveitis with hypopyon in a patient who was taking 600 mg of rifabutin daily. The rate of recurrence with the continuation of rifabutin s
Knowledge of HIV infection and the fear of mixing socially with HIV-infected and AIDS-sick patients among STD patients in Bergen, Norway.: Scand J Soc Med. 1995 Dec;23(4):242-50. Unique Identifier : AIDSLINE MED/97078442; Tveit KS; Nyfors A; Nilsen A; Jacobsen R; Section of Venereology, Department of Dermatology, Haukeland; University Hospital, Bergen, Norway.; This is a study of data from 599 STD (sexually transmitted disease) clinic patients in Bergen, Norway who visited the clinic in April-June 1989. We studied the patients knowledge of modes of HIV transmission and their degree of ignorance of how HIV is not transmitted. Particular i
[Autologous blood donation--good clinical practice and good recuperation practice]: Schweiz Med Wochenschr. 1996 Nov 16;126(46):1970-4. Unique Identifier : AIDSLINE MED/97103678; Hauser SP; Otth C; Franscini L; Nydegger UE; Hamatologisches Zentrallabor, Inselspital, Universitatsspital,; Bern.; Since October 1987, autologous blood donations have been performed in Bern and in 1994 reached a total of 946, representing 3% of all blood donations. This value is lower than the 4.9% for Switzerland as a whole. We report on the motivation and reasons of patients in favour of
[HIV infection, tuberculosis and tuberculin test in Switzerland. The Swiss HIV Cohort Study]: Schweiz Med Wochenschr. 1996 Nov 23;126(47):2007-12. Unique Identifier : AIDSLINE MED/97111939; Sudre P; Rieder H; Bassetti S; Hirschel BJ; Ledergerber B; Malvy D; Division des maladies infectieuses, Hopital universitaire de; Geneva, France.; BACKGROUND: The usefulness of the tuberculin skin test (TST) for HIV-infected subjects may be questioned because false-negative results are increasingly common with advanced immune deficiency. The objectives of this research were thus to describe the use and the results of TST among patients with HIV infection in
Cell suicide in health and disease.: Sci Am. 1996 Dec;275(6):80-7. Unique Identifier : AIDSLINE MED/97082527; Duke RC; Ojcius DM; Young JD
Ethics of AIDS study [letter]: Science. 1996 Dec 6;274(5293):1596. Unique Identifier : AIDSLINE MED/97129941; Gomperts ED; Donfield SM
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.: Science. 1996 Dec 6;274(5293):1739-44. Unique Identifier : AIDSLINE MED/97094384; Moore PS; Boshoff C; Weiss RA; Chang Y; School of Public Health, Columbia University, New York, NY 10032,; USA.; Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi s sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hema
Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41.: Science. 1996 Dec 13;274(5294):1917-21. Unique Identifier : AIDSLINE MED/97102597; Adamson DC; Wildemann B; Sasaki M; Glass JD; McArthur JC; Christov VI; Dawson TM; Dawson VL; Department of Neurology, Johns Hopkins University School of; Medicine, 600 North Wolfe Street, Pathology 2-210, Baltimore, MD; 21287, USA. valina.dawson@qmail.bs.jhu.edu; Indirect mechanisms are implicated in the pathogenesis of the dementia associated with human immunodeficiency virus-type 1 (HIV-1) infection. Proinflammatory molecules such as tumor necrosis factor alpha and eicosanoids are elevated in the central nervous system of patients with HI
Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines.: Science. 1996 Dec 13;274(5294):1924-6. Unique Identifier : AIDSLINE MED/97102599; Atchison RE; Gosling J; Monteclaro FS; Franci C; Digilio L; Charo IF; Goldsmith MA; Gladstone Institute of Virology and Immunology, School of; Medicine, University of California, San Francisco, Post Office; Box 419100, San Francisco, CA 94141-9100, USA.; mark_goldsmith@quickmail.ucsf.edu; The human beta-chemokine receptor CCR5 is an important cofactor for entry of human immunodeficiency virus-type 1 (HIV-1). The murine form of CCR5, despite its 82 percent identity to the human form, was not functional as an HIV-1 coreceptor. HIV-1 entry function could be reconstituted by fusion of various individual el
Breakthroughs of the year, 1996 [editorial]: Science. 1996 Dec 20;274(5295):1987. Unique Identifier : AIDSLINE MED/97136460; Bloom FE
New hope in HIV disease [news]: Science. 1996 Dec 20;274(5295):1988-9. Unique Identifier : AIDSLINE MED/97136461; Balter M
Baltimore to head new vaccine panel [news]: Science. 1996 Dec 20;274(5295):2005. Unique Identifier : AIDSLINE MED/97136465; Cohen J
Complexities in the treatment of autoimmune disease [comment]: Science. 1996 Dec 20;274(5295):2037-8. Unique Identifier : AIDSLINE MED/97136471; McFarland HF; Neuroimmunology Branch, National Institutes of Health, Bethesda,; MD 20892, USA. henrymcf@helix.nih.gov
Late complications of immune deviation therapy in a nonhuman primate [see comments]: Science. 1996 Dec 20;274(5295):2054-7. Unique Identifier : AIDSLINE MED/97113191; Genain CP; Abel K; Belmar N; Villinger F; Rosenberg DP; Linington C; Raine CS; Hauser SL; Department of Neurology, University of California, San Francisco,; CA 94143, USA.; The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerizat
Foodborne diseases.: Singapore Med J. 1996 Apr;37(2):197-204. Unique Identifier : AIDSLINE MED/97097699; Lee CC; Lam MS; Department of Infectious Diseases, Tan Tock Seng Hospital,; Singapore.; Foodborne diseases continue to cause significant morbidity and mortality both in developing and developed countries. Its spectrum has vastly expanded in recent years with the recognition of new foodborne pathogens and clinical syndromes. The increase in international travel and demand for exotic and raw food underscor
Toward a more holistic understanding of ethics in social work.: Soc Work Health Care. 1996;23(2):1-14. Unique Identifier : AIDSLINE MED/97011791; Abramson M; School of Social Work, Rutgers University, Brunswick, NJ 08903,; USA.; This paper explores alternative approaches to ethical understanding in social work by applying them to a story of a young woman with AIDS. After presenting the story, I present four perspectives on ethical discernment: the principles approach, virtue ethics, feminist ethics and Afrocentricity. Each approach raises dif
Medicaid eligibility policies for people with AIDS.: Soc Work Health Care. 1996;23(2):15-41. Unique Identifier : AIDSLINE MED/97011792; Buchanan RJ; Department of Community Health, University of Illinois, Champaign; 61820, USA.; Although Medicaid is the primary payer for health services provided to people with AIDS, Medicaid eligibility policies can be restrictive. This study presents Medicaid eligibility policies in each state for people with AIDS or HIV infection, including the categorical and medically needy classifications. The study docu
Negotiating advance directives for persons with AIDS.: Soc Work Health Care. 1996;23(2):43-65. Unique Identifier : AIDSLINE MED/97011793; Littrell J; Diwan S; Bryant CJ; A focus group was conducted to determine the views of persons with AIDS about how to best conduct the process of establishing advance directives. (Advance directives are instructions regarding future medical care to be implemented should a patient be unable to communicate his/her treatment preferences.) Several hypoth
The impact of a client's diagnosis of AIDS on social workers' clinical judgements: an experimental study.: Soc Work Health Care. 1996;23(4):35-50. Unique Identifier : AIDSLINE MED/97037534; Knight C; Department of Social Work, U.M.B.C., Catonsville, MD 21228, USA.; This article reports the findings and implications of a study in which the effect of the AIDS diagnosis, alone and in interaction with a client s race, gender and sexual orientation, on social workers clinical assessments was determined. The study utilized a constructed case history in which all information about the
Searching for information, understanding, and self-value: the utilization of peer support groups by gay men with HIV/AIDS.: Soc Work Health Care. 1996;23(4):51-74. Unique Identifier : AIDSLINE MED/97037535; Sandstrom KL; Department of Sociology, Anthropology, and Criminology,; University of Northern Iowa, USA.; The present study examined the patterns and variations characterizing the support group involvements of 25 gay men with HIV/AIDS. Results indicated that those men who participated in support groups on a long-term basis (i.e., one year or more) were less likely to have access to other social support networks. They were
Themes from the frontlines: hospital social work with people with AIDS.: Soc Work Health Care. 1996;23(4):75-89. Unique Identifier : AIDSLINE MED/97037536; Beckerman N; Rock M; Yeshiva University, Wurzweiler School of Social Work, Belfer; Hall, New York, NY 10033, USA.; There is little in the literature that specifically explores challenges and perceived rewards faced by direct care social work practitioners who work with an inpatient AIDS population, although there are hints (Egan, 1993, Oktay, 1992, and Gilmann, 1991). This article, based on a study of 20 designated inpatient AIDS
Religious crusade. School health is at center of battle for control of state's education system.: Tex Med. 1996 Feb;92(2):30-3. Unique Identifier : AIDSLINE MED/96431594; Ortolon K
Interactions between opportunistic micro-organisms and HIV in the lung [editorial]: Thorax. 1996 Sep;51(9):875-77. Unique Identifier : AIDSLINE MED/97105599; Clarke JR; Israel-Biet D
Lack of skin test reactivity to common mycobacterial antigens in human immunodeficiency virus infected individuals with high CD4 counts.: Thorax. 1996 Sep;51(9):932-5. Unique Identifier : AIDSLINE MED/97105611; Khoo SH; Wilkins EG; Fraser IS; Hamour AA; Stanford JL; Department of Infectious Diseases, North Manchester General; Hospital, UK.; BACKGROUND: T cell response to mycobacterial antigens may be directed against those antigens common to all mycobacteria (group i), those restricted to slow (group ii) or fast growers (group iii), or those which are species- or subspecies-specific (group iv). These responses were assessed by skin testing patients infec
[Cat-scratch disease in humans and the cat's role. Causative agents finally isolated (news)]: Tijdschr Diergeneeskd. 1996 Nov 15;121(22):664. Unique Identifier : AIDSLINE MED/97102166; Houwers DJ; Bergmans AM; Schouls LM; Nieuwenhuijs JH
Structural and functional correlates between HIV-1 and SIV Nef isolates.: Virology. 1996 Dec 15;226(2):161-6. Unique Identifier : AIDSLINE MED/97124639; Garcia JV; Foster JL; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38101, USA.; victor.garcia@stjude.org; The nef genes of HIV-1 and SIV encode 27-34 kDa myristoylated proteins which have been shown to induce cell surface CD4 downregulation and bind to a cellular protein kinase. To identify regions of Nef important for function, structure-function correlates of HIVSF2 nef (Nef) and SIVmm239open nef (SNef) were sought by c
HTLV-1 gene expression in adult T-cell leukemia cells elicits an NK cell response in vitro and correlates with cell rejection in SCID mice.: Virology. 1996 Dec 15;226(2):167-75. Unique Identifier : AIDSLINE MED/97124640; Stewart SA; Feuer G; Jewett A; Lee FV; Bonavida B; Chen IS; Department of Microbiology & Immunology, University of California; at Los Angeles School of Medicine 90095-1747, USA.; Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). We have previously shown that the ATL cell line, RV-ATL, formed tumors when inoculated into severe combined immunodeficient (SCID) mice. In contrast, the HTLV-1 in vitro-transformed cell line, SLB-1, was nontumorigenic i
Preliminary in vitro growth cycle and transmission studies of HIV-1 in an autologous primary cell assay of blood-derived macrophages and peripheral blood mononuclear cells.: Virology. 1996 Dec 15;226(2):205-16. Unique Identifier : AIDSLINE MED/97124645; Tsai WP; Conley SR; Kung HF; Garrity RR; Nara PL; Laboratory of Biochemical Physiology, NCI-FCRDC, Frederick,; Maryland 21702, USA.; Recent interest focused on the dynamics of HIV-1 replication in primary monocytes/macrophages and T-lymphocytes of the immune system, as well as the standardization of virological and immunological in vitro assays with primary isolates, provided the impetus for these studies. These types of studies have never been per
Role of the V2, V3, and CD4-binding domains of GP120 in curdlan sulfate neutralization sensitivity of HIV-1 during infection of T lymphocytes.: Virology. 1996 Dec 15;226(2):217-27. Unique Identifier : AIDSLINE GENBANK/M68893; Jagodzinski PP; Wustner J; Kmieciak D; Wasik TJ; Fertala A; Sieron AL; Takahashi M; Tsuji T; Mimura T; Fung MS; Gorny MK; Kloczewiak M; Kaneko Y; Kozbor D; Department of Microbiology, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107, USA.; A sulfated polysaccharide, curdlan sulfate (CRDS) with 1,3-beta-D-glucan as a main chain, inhibits HIV-1 infection of human peripheral blood lymphocytes (PBLs) by binding to the V3 region of gp 120. We previously showed that T cell (T)-tropic HIV-1 isolates are over 10-fold more sensitive to neutralization by CRDS tha
The Env-like open reading frame of the baculovirus-integrated retrotransposon TED encodes a retrovirus-like envelope protein.: Virology. 1996 Dec 15;226(2):252-9. Unique Identifier : AIDSLINE MED/97124650; Ozers MS; Friesen PD; Institute for Molecular Virology, Graduate School and College of; Agricultural and Life Sciences, University of Wisconsin at; Madison 53706, USA.; TED is a 7.5-kbp member of the gypsy family of retrotransposons that was first identified by its integration within the baculovirus DNA genome. This lepidopteran (moth) transposon contains three retrovirus-like genes, including functional gag and pol that yield reverse transcriptase-containing virus-like particles. To
Characterization of an envelope mutant of HIV-1 that interferes with viral infectivity.: Virology. 1996 Dec 15;226(2):260-8. Unique Identifier : AIDSLINE MED/97124651; Chen SS; Ferrante AA; Terwilliger EF; Division of Hematology/Oncology, Deaconess Hospital, Boston,; Massachusetts 02215, USA.; A mutant human immunodeficiency virus (HIV-1) provirus encoding an envelope (Env) protein with a truncated transmembrane protein cytoplasmic domain was defective for replication. Coexpression of the mutant with a wild-type (wt) HIV-1 provirus potently inhibited the production of infectious virus. The maximum inhibitor
Nucleotide sequences within the U5 region of the viral RNA genome are the major determinants for an human immunodeficiency virus type 1 to maintain a primer binding site complementary to tRNA(His).: Virology. 1996 Dec 15;226(2):306-17. Unique Identifier : AIDSLINE MED/97124655; Zhang Z; Kang SM; LeBlanc A; Hajduk SL; Morrow CD; Department of Microbiology, University of Alabama at Birmingham; 35294, USA.; The initiation of reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires cellular tRNA(Lys,3) as a primer and occurs at a site in the viral RNA genome, designated as the primer binding site (PBS), which is complementary to the 3 -terminal 18 nucleotides of tRNA(Lys,3). We previously d
Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.: Virology. 1996 Dec 15;226(2):362-73. Unique Identifier : AIDSLINE MED/97124661; Raber J; Toggas SM; Lee S; Bloom FE; Epstein CJ; Mucke L; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA.; The impact of HIV-1 expression in the brain on the development of AIDS is unknown. In the present study, we examined the hypothalamic-pituitary-adrenal (HPA) axis in a transgenic model in which expression of the HIV-1 envelope glycoprotein gp120 induced central nervous system (CNS) damage similar to that seen in HIV-1
The glycosylated gag protein of MuLV is a determinant of neuroinvasiveness: analysis of second site revertants of a mutant MuLV lacking expression of this protein.: Virology. 1996 Dec 15;226(2):384-92. Unique Identifier : AIDSLINE MED/97124663; Portis JL; Fujisawa R; Mcatee FJ; Laboratory of Persistent Viral Diseases, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, Hamilton, Montana 59840, USA. john_portis@nih.gov; Neuroinvasiveness is a property of all neurovirulent murine retroviruses, although the factors which facilitate infection of the CNS are not understood. We previously showed that mutant MuLV which lack expression of an accessory protein, glycosylated gag, had lost neurovirulence, indicating that this protein may be in
Distinct quasi-species in the blood and the brain of an HIV-2-infected individual.: Virology. 1996 Dec 15;226(2):418-23. Unique Identifier : AIDSLINE MED/97124668; Sankale JL; De La Tour RS; Marlink RG; Scheib R; Mboup S; Essex ME; Kanki PJ; Harvard AIDS Institute, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; Sequences of the HIV-2 envelope C2-C3 region were obtained after direct PCR amplification of proviral DNA from the brain and peripheral blood mononuclear cells of an HIV-2-infected AIDS patient. Tissue-specific sequences confirmed previous observations that HIV-2 is indeed present in the central nervous system of infe
Replication of primary HIV-1 isolates is inhibited in PM1 cells expressing sCD4-KDEL.: Virology. 1996 Dec 15;226(2):424-9. Unique Identifier : AIDSLINE MED/97124669; Degar S; Johnson JE; Boritz E; Rose JK; Department of Pathology, Yale University School of Medicine, New; Haven, Connecticut 06510, USA.; Expression of a soluble CD4 molecule (sCD4-KDEL) containing a specific retention signal for the endoplasmic reticulum was shown previously to block propagation of the HIV-1MN prototype strain in a transformed T cell line. However, the virus present in HIV-1-infected individuals is more closely represented by primary H
HIV infection: from the pathophysiological approach to specific therapeutic interventions [editorial]: Acta Clin Belg. 1996;51(5):307-10. Unique Identifier : AIDSLINE MED/97108252; Clumeck N
Cyclophosphamide and interleukin-12 synergistically upregulate the acquisition of allergic contact dermatitis in the mouse.: Acta Derm Venereol. 1996 Jul;76(4):277-9. Unique Identifier : AIDSLINE MED/97023323; Maguire HC Jr; Department of Medicine, Thomas Jefferson University,; Philadelphia, PA 19107, USA.; Cyclophosphamide given before allergen and recombinant interleukin-12 administered at the time of allergic sensitization substantially increase the acquisition of allergic contact dermatitis in the mouse. Since their immunoadjuvant mechanisms appeared different, it seemed probable that combining cyclophosphamide pretr
Local expression of migration inhibitory factor and Th1 type cytokine mRNA in sporotrichosis lesions [letter]: Acta Derm Venereol. 1996 Jul;76(4):321-2. Unique Identifier : AIDSLINE MED/97023335; Fujimura T; Asai T; Miyata T; Muguruma K; Masuzawa M; Katsuoka K
Secondary erythermalgia in an HIV-infected patient. Is there a pathogenic relationship? [letter]: Acta Derm Venereol. 1996 Jul;76(4):332-3. Unique Identifier : AIDSLINE MED/97023341; Itin PH; Courvoisier S; Stoll A; Battegay M
Cognitive decline in patients with symptomatic HIV-1 infection. No decline in asymptomatic infection.: Acta Neurol Scand. 1996 Jun;93(6):421-7. Unique Identifier : AIDSLINE MED/96433317; Poutiainen E; Elovaara I; Raininko R; Vilkki J; Lahdevirta J; Iivanainen M; Department of Neurology, Helsinki University Hospital, Finland.; Thirty-six HIV-1-infected predominantly well-functioning subjects were followed up for one year by repeated neuropsychological, clinical neurological, neuroradiological, and immunological examinations. Changes in cognitive performance related to the severity of HIV-1 infection as well as to neuroradiological or immuno
2-Mercapto-N-(azolyl)benzenesulphonamides. I. Synthesis of N-(1,1-dioxo-1,4,2-benzodithiazin-3-yl)guanidines and their transformations into 2-mercapto-N-(5-amino-1,2,4-triazol-3-yl) benzenesulphonamide derivatives with potential anti-HIV or anticancer activity.: Acta Pol Pharm. 1995 Mar-Apr;52(2):91-101. Unique Identifier : AIDSLINE MED/97119418; Brzozowski Z; Department of Drug Technology, Faculty of Pharmacy, School of; Medicine, Gdansk, Poland.; N-(1,1-Dioxo-1,4,2-benzodithiazin-3-yl)-N -R3-guanidines [IIa-IIo] were prepared from the corresponding 3-methylthio-1,4,2-benzodithiazine 1,1-dioxide derivatives [Ia-Id]. Depending on electronic effects of R3 substituents, hydrazinolysis of the benzodithiazinylguanidines [II] afforded the following derivatives in goo
[Biochemical changes in cerebrospinal fluid associated with the neurotoxic action of HIV-1]: Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1996 Jul-Aug;24(4):209-18. Unique Identifier : AIDSLINE MED/97090828; Gomez Alcalde MS; Reyes Martin A; Departamento de Ciencias Sanitarias y Medico Sociales de la; Facultad de Medicina de Alcala de Henares.; The aim of this study is to evaluate the usefulness of different markers to diagnose neurologic and psychiatric diseases due to HIV-1 infection Increased concentration of quinolenic acid has been implicated in the neurologic deficits and brain atrophy that may accompany infection with the HIV-1 virus. CFS concentratio
TB or not TB? how to interpret a skin test.: Am J Nurs. 1996 Dec;96(12):12-3. Unique Identifier : AIDSLINE MED/97121186; Finkelstein L; Hopkins ML; Mount Sinai Medical Center, New York, NY, USA.
Policy statement on needle exchange programs.: Am J Psychiatry. 1996 Dec;153(12):1660. Unique Identifier : AIDSLINE MED/97097936
Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo.: Ann N Y Acad Sci. 1996 Oct 31;795:1-12. Unique Identifier : AIDSLINE MED/97118029; Gately MK; Carvajal DM; Connaughton SE; Gillessen S; Warrier RR; Kolinsky KD; Wilkinson VL; Dwyer CM; Higgins GF Jr; Podlaski FJ; Faherty DA; Familletti PC; Stern AS; Presky DH; Department of Inflammation/Autoimmune Diseases, Hoffmann-La Roche; Inc., Nutley, New Jersey 07110, USA.; Mo(p40)2 is a potent IL-12 antagonist that interacts strongly with the beta 1 subunit of the IL-12R to block binding of moIL-12 to the high-affinity mouse IL-12R. Mo(p40)2, alone or in synergy with the 2B5 mAb specific for the moIL-12 heterodimer, blocked IL-12-induced responses in vitro, Mo(p40)2 was thus used alone
Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses.: Ann N Y Acad Sci. 1996 Oct 31;795:116-26. Unique Identifier : AIDSLINE MED/97118039; Kelsall BL; Stuber E; Neurath M; Strober W; Mucosal Immunity Section, National Institutes of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. Kelsall@nih.gov; Recent studies have demonstrated that the treatment of mice with anti-gp39 antibodies impairs T-cell functions in the murine collagen type II-induced arthritis model, in acute semi-allogenic graft-versus-host disease, and in the allo-specific CTL-reaction, that is, reactions that are believed to be mediated by Th1-typ
Regulation of interleukin-12 production.: Ann N Y Acad Sci. 1996 Oct 31;795:13-25. Unique Identifier : AIDSLINE MED/97118030; Ma X; Aste-Amezaga M; Trinchieri G; Wistar Institute of Anatomy and Biology, Philadelphia,; Pennsylvania 19104, USA.
Regulation of IL-12 production by human monocytes and the influence of prostaglandin E2.: Ann N Y Acad Sci. 1996 Oct 31;795:147-57. Unique Identifier : AIDSLINE MED/97118042; van der Pouw Kraan TC; Boeije LC; Snijders A; Smeenk RJ; Wijdenes J; Aarden LA; The Netherlands, Red Cross Blood Transfusion Service, Department; of Auto-immune Diseases, Amsterdam, The Netherlands.
Both IL-2 and IL-4 synergize with IL-12 to induce a CTL response, a response completely blocked by TGF-beta.: Ann N Y Acad Sci. 1996 Oct 31;795:168-80. Unique Identifier : AIDSLINE MED/97118044; Herrmann S; Abdi K; Department of Cellular Immunology Genetics Institute, Inc.,; Cambridge, Massachusetts 02140, USA. @Genetics.com
Role of interleukin-12 in the maturation of naive human CD4 T cells.: Ann N Y Acad Sci. 1996 Oct 31;795:196-201. Unique Identifier : AIDSLINE MED/97118047; Delespesse G; Yang LP; Shu U; Byun DG; Demeure CE; Ohshima Y; Wu CY; Sarfati M; University of Montreal Louis-Charles Simard Research Center,; Notre-Dame Hospital, Montreal, Canada.
An IL-12-based vaccine approach for preventing immunopathology in schistosomiasis.: Ann N Y Acad Sci. 1996 Oct 31;795:202-7. Unique Identifier : AIDSLINE MED/97118048; Sher A; Jankovic D; Cheever A; Wynn T; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, Bethesda, Maryland 20892, USA.; Schistosomiasis is a major parasitic disease of developing countries. Pathology in schistosome infection is caused by the host granulomatous response to parasite eggs deposited in the tissues and the ensuing fibrosis. Previous work established that Th2 CD4+ cells play a major role in expanding granulomatous lesions an
The role of IL-12 in the pathogenesis of Th1 cell-mediated autoimmune diseases.: Ann N Y Acad Sci. 1996 Oct 31;795:208-15. Unique Identifier : AIDSLINE MED/97118049; Adorini L; Gregori S; Magram J; Trembleau S; Roche Milano Ricerche, Milano, Italy.
Regulation of experimental autoimmune encephalomyelitis by interleukin-12.: Ann N Y Acad Sci. 1996 Oct 31;795:216-26. Unique Identifier : AIDSLINE MED/97118050; Leonard JP; Waldburger KE; Goldman SJ; Genetics Institute, Andover, Massachusetts 01810, USA.; We have evaluated the effects of rmIL-12 on the course of adoptively transferred EAE. When mice were injected with LNC that had been stimulated in vitro with PLP in the presence of rmIL-12, the subsequent course of disease was more severe and prolonged than controls. In vitro stimulation with PLP in the presence of IL
Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice.: Ann N Y Acad Sci. 1996 Oct 31;795:241-9. Unique Identifier : AIDSLINE MED/97118052; O'Hara RM Jr; Henderson SL; Nagelin A; Genetics Institute, Laboratory of Molecular Immunology,; Cambridge, Massachusetts 02140, USA.; The effects of interleukin-12 on autoimmune diabetes in nonobese diabetic mice was examined. IL-12 was given, intraperitoneally, to NOD females in two different treatment protocols: three times a week, for 2 weeks beginning at 9 weeks of age and a single weekly injection, for 15 weeks, beginning at 9 weeks of age. A s
The role of IL-12 in regulation of T helper cell subsets in vivo. Lessons from experimental cutaneous leishmaniasis.: Ann N Y Acad Sci. 1996 Oct 31;795:250-6. Unique Identifier : AIDSLINE MED/97118053; Scott P; Hondowicz B; Eaton A; Scharton-Kersten T; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia 19104, USA.
Interleukin-12 as vaccine adjuvant. Characteristics of primary, recall, and long-term responses.: Ann N Y Acad Sci. 1996 Oct 31;795:26-35. Unique Identifier : AIDSLINE MED/97118031; Bliss J; Maylor R; Stokes K; Murray KS; Ketchum MA; Wolf SF; Genetics Institute Inc., Cambridge, Massachusetts 02140, USA.
Cellular and molecular mechanisms underlying IL-12-induced tumor regression.: Ann N Y Acad Sci. 1996 Oct 31;795:294-309. Unique Identifier : AIDSLINE MED/97118058; Fujiwara H; Clark SC; Hamaoka T; Biomedical Research Center, Osaka University Medical School,; Japan.
The therapeutic effect of interleukin-12 or its antagonist in transplantation immunity.: Ann N Y Acad Sci. 1996 Oct 31;795:371-4. Unique Identifier : AIDSLINE MED/97118075; Nishimura T; Sadata A; Yahagi C; Santa K; Otsuki K; Watanabe K; Yahata T; Habu S; Department of Immunology, Tokai University School of Medicine,; Isehara, Japan.
Effect of interleukin-12 on the cytokine profile of human CD4 and CD8 T-cell clones.: Ann N Y Acad Sci. 1996 Oct 31;795:382-3. Unique Identifier : AIDSLINE MED/97118078; Paganin C; Gerosa F; Peritt D; Paiola F; Scupoli MT; Aste-Amezaga M; Frank I; Trinchieri G; Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Interleukin-12 gene expression mediates the accelerating effect of cyclophosphamide in autoimmune disease.: Ann N Y Acad Sci. 1996 Oct 31;795:397-9. Unique Identifier : AIDSLINE MED/97118083; Rothe H; Burkart V; Faust A; Kolb H; Diabetes Research Institute, Heinrich-Heine University of; Dusseldorf, Germany.
Mechanism of the induction of anti-tumor immunity by B7.1 and interleukin-12.: Ann N Y Acad Sci. 1996 Oct 31;795:429-33. Unique Identifier : AIDSLINE MED/97118092; Wysocka M; Coughlin CM; Kurzawa HL; Trinchieri G; Eck SL; Lee WM; Wistar Institute, University of Pennsylvania, Philadelphia 19104,; USA.
IL-12-deficient mice are defective but not devoid of type 1 cytokine responses.: Ann N Y Acad Sci. 1996 Oct 31;795:60-70. Unique Identifier : AIDSLINE MED/97118034; Magram J; Sfarra J; Connaughton S; Faherty D; Warrier R; Carvajal D; Wu CY; Stewart C; Sarmiento U; Gately MK; Department of Biotechnology, Hoffmann-La Roche, Nutley, New; Jersey 07110, USA.; Interleukin-12 (IL-12) has been described as a pivotal molecule in the immune response based in part on its ability to influence the differentiation of T helper (Th) cells into a type 1 (Th1) phenotype. This event is crucial in that appropriate differentiation of naive T cells can determine susceptibility or resistanc
Effects of IL-12 in memory CD4+ T lymphocyte responses.: Ann N Y Acad Sci. 1996 Oct 31;795:88-99. Unique Identifier : AIDSLINE MED/97118037; Umetsu DT; Gieni R; DeKruyff RH; Department of Pediatrics, Stanford University, California; 94305-5119, USA.
Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription.: Antimicrob Agents Chemother. 1996 Mar;40(3):527-40. Unique Identifier : AIDSLINE MED/97004255; Arts EJ; Wainberg MA; McGill University AIDS Centre, Montreal, Quebec, Canada.
Single-dose and steady-state pharmacokinetics of a novel microfluidized suspension of atovaquone in human immunodeficiency virus-seropositive patients.: Antimicrob Agents Chemother. 1996 Mar;40(3):556-60. Unique Identifier : AIDSLINE MED/97004259; Dixon R; Pozniak AL; Watt HM; Rolan P; Posner J; Department of Clinical Pharmacology, Wellcome Research; Laboratories, Kent, United Kingdom.; The single- and multiple-dose pharmacokinetics of and tolerability to a new microfluidized suspension of atovaquone were studied in human immunodeficiency virus-seropositive patients with CD4 counts of
Susceptibilities of Candida spp. to antifungal agents visualized by two-dimensional scatterplots of relative growth.: Antimicrob Agents Chemother. 1996 Mar;40(3):588-94. Unique Identifier : AIDSLINE MED/97004265; Odds FC; Dams G; Just G; Lewi P; Department of Bacteriology and Mycology, Janssen Research; Foundation, Beerse, Belgium.; The growth of 811 clinical yeast isolates in the presence of single concentrations of antifungal agents was measured spectrophotometrically and expressed as a percentage of growth in inhibitor-free control cultures. Two-dimensional scatterplots of the relative growth data allowed for the simple visual determination of
Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.: Antimicrob Agents Chemother. 1996 Mar;40(3):642-5. Unique Identifier : AIDSLINE MED/97004275; Rajagopalan P; Boudinot FD; Chu CK; Tennant BC; Baldwin BH; Schinazi RF; Department of Pharmaceutics, University of Georgia, Athens 30602,; USA.; The woodchuck (Marmota monax) has proven to be a suitable animal model for studying hepatitis B virus (HBV) infection owing to similarities in the course of infection between woodchuck hepatitis virus (WHV) in woodchucks and HBV in humans. (-)-beta-L-2 ,3 -Dideoxy-3 -thiacytidine (
In vitro activities of rifabutin, azithromycin, ciprofloxacin, clarithromycin, clofazimine, ethambutol, and amikacin in combinations of two, three, and four drugs against Mycobacterium avium.: Antimicrob Agents Chemother. 1996 Mar;40(3):743-9. Unique Identifier : AIDSLINE MED/97004293; Yajko DM; Sanders CA; Madej JJ; Cawthon VL; Hadley WK; Department of Laboratory Medicine, University of California, San; Francisco 94110, USA. yajko/labmed.ucsf.edu; Multidrug therapy is recommended for treatment of Mycobacterium avium complex (MAC) bacteremia in patients with AIDS. Azithromycin, clarithromycin, rifabutin, ciprofloxacin, ethambutol, clofazimine, and amikacin have all been suggested for use in treating MAC bacteremia, but the most active combinations of these drugs
Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry.: Antimicrob Agents Chemother. 1996 Mar;40(3):750-4. Unique Identifier : AIDSLINE MED/97004294; Datema R; Rabin L; Hincenbergs M; Moreno MB; Warren S; Linquist V; Rosenwirth B; Seifert J; McCune JM; Sandoz Research Institute, Vienna, Austria.; SID 791, a bicyclam inhibiting human immunodeficiency virus (HIV) replication in vitro by blocking virus entry into cells, is an effective inhibitor of virus production and of depletion of human CD4+ T cells in HIV type 1-infected SCID-hu Thy/Liv mice. Steady levels of 100 ng of SID 791 or higher per ml in plasma resu
Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds.: Antimicrob Agents Chemother. 1996 Mar;40(3):755-62. Unique Identifier : AIDSLINE MED/97004295; Rabin L; Hincenbergs M; Moreno MB; Warren S; Linquist V; Datema R; Charpiot B; Seifert J; Kaneshima H; McCune JM; Preclinical Testing Group, SyStemix, Inc., Palo Alto, California,; USA.; We have developed standardized procedures and practices for infection of SCID-hu Thy/Liv mice with human immunodeficiency virus type 1 for the prophylactic administration of antiviral compounds and for evaluation of the antiviral effect in vivo. Endpoint analyses included quantitation of viral load by intracellular p2
Didanosine reduces atevirdine absorption in subjects with human immunodeficiency virus infections.: Antimicrob Agents Chemother. 1996 Mar;40(3):767-71. Unique Identifier : AIDSLINE MED/97004297; Morse GD; Fischl MA; Shelton MJ; Borin MT; Driver MR; DeRemer M; Lee K; Wajszczuk CP; Department of Pharmacy Practice, State University of New York at; Buffalo, Amherst, NY 14260, USA.; Atevirdine is a nonnucleoside reverse transcriptase inhibitor with in vitro activity against human immunodeficiency virus type 1 and is currently in phase II clinical trials. Atevirdine is most soluble at a pH of
In vitro susceptibilities of clinical and environmental isolates of Cryptococcus neoformans to five antifungal drugs.: Antimicrob Agents Chemother. 1996 Mar;40(3):822-4. Unique Identifier : AIDSLINE MED/97004313; Franzot SP; Hamdan JS; Department of Microbiology, Federal University of Minas Gerais,; Brazil. franzot@oraculo.lcc.ufmg.br; A total of 53 Cryptococcus neoformans strains, including clinical and environmental Brazilian isolates, were tested for their susceptibilities to amphotericin B, 5-flucytosine, ketoconazole, fluconazole, and itraconazole. The tests were performed according to the National Committee of Clinical Laboratory Standards rec
Thermal inactivation of bovine immunodeficiency virus.: Appl Environ Microbiol. 1996 Nov;62(11):4280-3. Unique Identifier : AIDSLINE MED/97055737; Moore EC; Keil D; Coats KS; Department of biological Sciences, Mississippi State University,; Mississippi 39762, USA.; Cell-associated bovine immunodeficiency virus (BIV) and cell-free BIV were subjected to increasing temperatures, including pasteurization conditions. To determine the effect of heat treatment on BIV viability, reverse transcriptase activity and infectivity of the heat-treated virus were assessed. BIV was inactivated b
Effects of Pityrosporum ovale on proliferation, immunoglobulin (IgA, G, M) synthesis and cytokine (IL-2, IL-10, IFN gamma) production of peripheral blood mononuclear cells from patients with seborrhoeic dermatitis.: Arch Dermatol Res. 1996 Aug;288(9):532-6. Unique Identifier : AIDSLINE MED/97028735; Neuber K; Kroger S; Gruseck E; Abeck D; Ring J; Department of Dermatology and Allergology, University Hospital; Hamburg-Eppendort, Germany.; The aetiology of seborrhoeic dermatitis (SD) is still unknown. An increased number of Pityrosposurm ovale in lesional skin of patients with SD has been suggested to play a crucial role in the pathogenesis of the disease since double-blind trials with antifungal drugs (e.g. ketoconazole) have shown that these agents re
Quantitation of IL-2Rp75 (CD122) expression on mononuclear cells in rheumatic disease.: Ann Rheum Dis. 1996 Nov;55(11):844-7. Unique Identifier : AIDSLINE MED/97130992; Creamer P; Hall ND; Rheumatology Unit, Bristol Royal Infirmary, United Kingdom.; OBJECTIVE: To compare expression of the p75 chain of the interleukin-2 receptor (IL-2Rp75, CD122) on peripheral and synovial mononuclear cells in rheumatoid and non-rheumatoid inflammatory arthritis. METHODS: Peripheral blood (PBMC) and synovial (SFMC) mononuclear cells were isolated from subjects with rheumatoid arth
Management of AIDS-related pneumothorax.: Ann Thorac Surg. 1996 Dec;62(6):1608-13. Unique Identifier : AIDSLINE MED/97116271; Trachiotis GD; Vricella LA; Alyono D; Aaron BL; Hix WR; Department of Surgery, George Washington University Medical; Center, Washington, DC 20037, USA.; BACKGROUND: Pneumothorax (PTX) occurs in 5% of patients with acquired immunodeficiency syndrome (AIDS) infected with Pneumocystis carinii pneumonia, and up to 50% of those will die during hospitalization. The treatment strategies for managing AIDS-related PTXs are often complex and ineffective at treating the PTX, and
[Cerebrospinal fluid in 50 AIDS patients]: Arq Neuropsiquiatr. 1996 Jun;54(2):227-31. Unique Identifier : AIDSLINE MED/97104613; Hinrichsen SL; Ataide Junior L; Travassos F; Travassos P; Alburquerque E; Moura L; Arraes LC; Rocha LV; Amorim MR; Luz LM; Braga A; Servico de Doencas Infecciosas e Paraitarias, Universidade; Federal de Pernambuco.; Fifty AIDS patients were studied. All patients had anti-HIV antibodies (ELISA) present and met OPAS/Caracas punctuation criteria for AIDS cases in adults. Cerebrospinal fluid (CSF) analysis included pressure, cytology (number of cytomorphological aspects), total protein and electrophoresis, glucose and chloride concen
[Transverse myelitis as initial symptom of disseminated non-Hodgkin lymphoma and HIV-associated vacuolar myelopathy: case report]: Arq Neuropsiquiatr. 1996 Jun;54(2):318-23. Unique Identifier : AIDSLINE MED/97104627; Moura LP; Silvestre MT; Araujo FR; Burgarelli MK; Borges AS; Vinhal FA; Rocha A; Raffin CN; Ferreira MS; Faculdade de Medicina da Universidade Federal de Uberlandia,; Minas Gerais, Brasil.; Non-Hodgkin lymphoma is frequently seen in AIDS patients usually affecting the central nervous system (CNS), especially the leptomeninges and the cerebral hemispheres. The epidural involvement is rarely described, ranging from 3.5% to 8.3% among the CNS sites. The authors present a case of disseminated non Hodgkin lym
[Cerebral malaria and AIDS: case report]: Arq Neuropsiquiatr. 1996 Jun;54(2):324-7. Unique Identifier : AIDSLINE MED/97104628; Hinrichsen SL; Moura LV; Ataide Junior L; Travassos F; Travassos P; Albuquerque E; Sepulveda DP; Amorim MR; Luz LM; Braga AA; Rocha LV; Servico de Doencas Infecciosas e Parasitarias, Universidade; Feeral de Pernambuco, Brasil.; Although it has not been definitely proven that the severity of malaria is associated to human immunodeficiency virus (HIV) we know that infection through Plasmodium falciparum can favor a rapid evolution of the HIV infection. Besides, association of malaria with HIV/AIDS from a clinical point of view can be clinicall
[Neuropathogenesis of HIV infection]: Arq Neuropsiquiatr. 1996 Jun;54(2):335-45. Unique Identifier : AIDSLINE MED/97104631; Araujo AD; Araujo AP; Novis SA; Servico de Neurologia, Universidade Federal do Rio de Janeiro.; The spreading of human immunodeficiency virus (HIV) infection and its increasing scientific knowledge keep the medical staff involved with these patients in permanent need of updating themselves. The different neurologic manifestations caused by HIV are related to a variety of pathogenic mechanisms, as follows: immuno
National HIV education program for Australian doctors [news]: Aust Fam Physician. 1996 May;25(5):635. Unique Identifier : AIDSLINE MED/97089629
A review of antifungal agents.: Aust Fam Physician. 1996 May;25(5):717-9, 721. Unique Identifier : AIDSLINE MED/97089640; Speed B; Infectious Disease, Fairfield Hospital.; A vigorous approach to the management of fungal related diseases has been precipitated by a number of issues; HIV/AIDS being one of the most prominent. In line with this there have been a number of new developments that all practitioners should know about. This article reviews the appropriate use of all agents current
Low temperature enhancement of reporter genes expression directed by human immunodeficiency virus type 1 long terminal repeat.: Biochem Biophys Res Commun. 1996 Nov 21;228(3):695-703. Unique Identifier : AIDSLINE MED/97096317; Chevrier-Miller M; Morange M; Arrigo AP; Pinto M; Ecole Normale Superieure, CNRS-URA 1302, Paris, France.; Bacteria and eukaryotic cells respond to cold stress by inducing and enhancing the synthesis of specific arrays of proteins. We describe here cold-induced enhancement of expression for two reporter genes; luciferase and beta-galactosidase, both under the control of HIV-1 LTR sequences, observed in mouse fibroblasts an
Further study of the mechanism underlying the cellular resistance to AZT.: Biochem Biophys Res Commun. 1996 Nov 21;228(3):797-801. Unique Identifier : AIDSLINE MED/97096332; Turriziani O; Antonelli G; Focher F; Bambacioni F; Dianzani F; Institute of Virology, University La Sapienza, Rome, Italy.; It has previously been shown that the lymphoblastoid cell line CEM, when propagated in the presence of increasing concentrations of 3 -azido-3 -deoxythymidine, became defective in thymidine kinase activity and resistant to the cytostatic and antiviral activities of
NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain.: Biochem Biophys Res Commun. 1996 Dec 4;229(1):299-304. Unique Identifier : AIDSLINE MED/97112442; Corasaniti MT; Navarra M; Catani MV; Melino G; Nistico G; Finazzi-Agro A; Faculty of Pharmacy, University of Reggio Calabria, Catanzaro,; Italy.; Treatment of neuroblastoma cultures with N-methyl-D-aspartate (NMDA) or human immunodeficiency virus type 1 (HIV-1) coat protein, gp120, induces significant cytotoxic effects which are reduced by leupeptin, E-64, N-Ac-Leu-Leu-norleucinal (ALLnL) as well as by N-Ac-Leu-Leu-normethioninal (ALLnM) and this suggests that
Relative levels of inhibition of p24 gene expression by different 20-mer antisense oligonucleotide sequences targeting nucleotides + 1129 to + 1268 of the HIV-1 gag genome: an analysis of mechanism.: Biochem Biophys Res Commun. 1996 Dec 4;229(1):305-9. Unique Identifier : AIDSLINE MED/97112443; Anazodo MI; Duta E; Friesen AD; Wright JA; Manitoba Institute of Cell Biology, University of Manitoba,; Winnipeg, Canada.; GPI2A is a 20-mer antisense oligonucleotide sequence that is complementary to a region of the HIV-1 gag gene. An analysis of viral core antigen p24 protein synthesis inhibition was performed with cells expressing HIV-1 proteins, following treatment with GPI2A or eight other unique antisense constructs designed to bind
The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena.: Biochem Biophys Res Commun. 1996 Dec 4;229(1):73-9. Unique Identifier : AIDSLINE MED/97112405; Mahmood N; Piacente S; Pizza C; Burke A; Khan AI; Hay AJ; MRC Collaborative Centre, London, United Kingdom.; Water and methanol extracts of Rosa damascena exhibited moderate anti-HIV activity. The anti-viral activities of 9 compounds isolated from the methanol extract were compared. The tetrahydroxyflavanone (kaempferol, 1), was effective in reducing the maturation of infectious progeny virus apparently due to selective inhi
Growth dominance of a revertant virus generated during in vitro serial passage of nef frameshift mutant of HIV-1.: Biochem Biophys Res Commun. 1996 Dec 4;229(1):96-101. Unique Identifier : AIDSLINE MED/97112409; Fujinaga K; Nakamura Y; Zhong Q; Nakaya T; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; We prepared a series of nef mutant HIV-1 with a frameshift mutation at the Xho I site by up to 50 serial transfers into MT-4 cells. Here, we studied revertants. Immunofluorescence using an anti-Nef monoclonal antibody revealed that cells first became Nef antigen-positive at the 23rd passage. The percentage of Nef anti
Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells.: Biochem Pharmacol. 1997 Jan 10;53(1):75-87. Unique Identifier : AIDSLINE MED/97119243; Martin LT; Faraj A; Schinazi RF; Gosselin G; Mathe C; Imbach JL; Sommadossi JP; Department of Pharmacology and Toxicology, University of Alabama; at Birmingham 35294, USA.; The beta-L enantiomers of 2 ,3 -dideoxycytidine (beta-L- ddC ) and its 5-fuoro derivative, 2 ,3 -dideoxy-5-fluorocytidine (beta-L-FddC), were demonstrated to be active against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) replication in
Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis.: Arthritis Rheum. 1996 Dec;39(12):1961-9. Unique Identifier : AIDSLINE MED/97121234; Dolhain RJ; van der Heiden AN; ter Haar NT; Breedveld FC; Miltenburg AM; Leiden University Hospital, Department of Rheumatology, The; Netherlands.; OBJECTIVE: To investigate whether T cells in the inflamed joints of patients with rheumatoid arthritis (RA) preferentially produce the T helper 1 (Th1) cytokines, interferon-gamma (IFN gamma) and interleukin-2 ( IL-2 ), or the Th2 cytokine, IL-4, when compared with corre
Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells.: Immunol Today. 1996 May;17(5):217-24. Unique Identifier : AIDSLINE MED/97104958; Levy JA; Mackewicz CE; Barker E; Cancer Research Institute, University of California San Francisco; 94143-0128, USA. jalevy@itsa.ucsf.edu; Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8+ T-cell antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and
Antibody neutralization of HIV-1.: Immunol Today. 1996 May;17(5):239-46. Unique Identifier : AIDSLINE MED/97104961; Poignard P; Klasse PJ; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, Marseille, France.; Neutralizing antibodies are a major component of host defense against viruses, and appear to be particularly important in limiting the spread of cell-free virus. Results from vaccine trials in animal models suggest that these antibodies may contribute to protection against human immunodeficiency virus (HIV) infection.
Cobalamin.: Crit Rev Clin Lab Sci. 1996;33(4):247-356. Unique Identifier : AIDSLINE MED/97029014; Markle HV; Centenary Health Centre, Scarborough, Ontario, Canada.; Cobalamin (vitamin B12) is an essential nutrient derived exclusively from bacterial sources. It is an essential cofactor for three known enzymatic reactions. Untreated deficiency, caused by either the autoimmune disease pernicious anemia or nutritional lack, results in a macrocytic anemia and/or subacute combined dege
Reduced CD4 cell counts in blood do not reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV-1 infection.: AIDS. 1996 Sep;10(10):F35-8. Unique Identifier : AIDSLINE MED/97028607; Rosok BI; Bostad L; Voltersvik P; Bjerknes R; Olofsson J; Asjo B; Brinchmann JE; Department of Microbiology and Immunology, Gade Institute,; University of Bergen, Norway.; OBJECTIVE: To investigate whether the loss of CD4 cells seen in peripheral circulation of HIV-1-positive individuals reflects a similar depletion of CD4 cells from lymphoid tissue. DESIGN: CD4 and CD8 cells in tonsillar mononuclear cell suspensions were quantified relative to tonsillar B cells, as these were thought t
Factors affecting survival in patients with the acquired immunodeficiency syndrome [editorial]: AIDS. 1996 Sep;10(10):1057-65. Unique Identifier : AIDSLINE MED/97028608; Mocroft A; Johnson MA; Phillips AN
Independent evolution of the env and pol genes of HIV-1 during zidovudine therapy.: AIDS. 1996 Sep;10(10):1067-73. Unique Identifier : AIDSLINE +; Brown AJ; Cleland A; Centre for HIV Research, University of Edinburgh, UK.; OBJECTIVE: To determine the effect that selection for antiviral resistance in the HIV-1 pol gene has on the level of variation and pattern of evolution in the V3 region of env. DESIGN: Proviral genomes obtained from two patients before, during and after the termination of zidovudine (ZDV) therapy (approximately 2 year
Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules.: AIDS. 1996 Sep;10(10):1075-83. Unique Identifier : AIDSLINE MED/97028610; Shiga H; Shioda T; Tomiyama H; Takamiya Y; Oka S; Kimura S; Yamaguchi Y; Gojoubori T; Rammensee HG; Miwa K; Takiguchi M; Institute of Medical Science, University of Tokyo, Japan.; OBJECTIVE: To identify HIV-1 cytotoxic T lymphocyte (CTL) epitopes presented by human leukocyte antigen (HLA)-B35 molecules that are associated with the accelerated progression of AIDS using a reverse immunogenetic approach. METHODS: 8-mer to 11-mer sequences carrying two anchor residues at position 2 and the carboxy-
Heat-mediated immune complex dissociation and enzyme-linked immunosorbent assay signal amplification render p24 antigen detection in plasma as sensitive as HIV-1 RNA detection by polymerase chain reaction.: AIDS. 1996 Sep;10(10):1085-90. Unique Identifier : AIDSLINE MED/97028611; Schupbach J; Flepp M; Pontelli D; Tomasik Z; Luthy R; Boni J; Swiss National Centre for Retroviruses, University of Zurich,; Switzerland.; OBJECTIVE: To compare heat denaturation and acidification as immune complex dissociation (ICD) methods in adult HIV-1 infection and to increase the sensitivity by a signal-amplification-boosted HIV-1 p24 antigen enzyme-linked immunosorbent assay (ELISA). DESIGN: Prospective and retrospective blinded study of paired se
Serological and polymerase chain reaction-based analysis of aqueous humour samples in patients with AIDS and necrotizing retinitis.: AIDS. 1996 Sep;10(10):1091-9. Unique Identifier : AIDSLINE MED/97028612; Verbraak FD; Galema M; van den Horn GH; Bruinenberg M; Luyendijk L; Danner SA; Kijlstra A; Department of Ophthalmology, Academic Medical Centre, University; of Amsterdam, The Netherlands.; OBJECTIVE: To evaluate the measurement of intraocular antibody production and detection of DNA by the polymerase chain reaction (PCR) for diagnosis of the causative microorganism in patients with AIDS and necrotizing retinitis. METHODS: Paired serum and aqueous humour samples obtained from 28 patients with AIDS and ne
Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group.: AIDS. 1996 Sep;10(10):1101-5. Unique Identifier : AIDSLINE MED/97028613; Mocroft A; Youle M; Gazzard B; Morcinek J; Halai R; Phillips AN; Department of Primary Care and Populations Sciences, Royal Free; Hospital School of Medicine, London, UK.; OBJECTIVE: With the recent identification of a new herpesvirus in patients with Kaposi s sarcoma (human herpesvirus-8 or Kaposi s sarcoma-associated herpesvirus), there have been several reports on the use of anti-herpesvirus therapy (foscarnet, ganciclovir and aciclovir) and risk of developing Kaposi s sarcoma. We th
Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group.: AIDS. 1996 Sep;10(10):1107-12. Unique Identifier : AIDSLINE MED/97028614; Katlama C; Mouthon B; Gourdon D; Lapierre D; Rousseau F; Pitie-Salpetriere Hospital, University of Paris VI, France.; OBJECTIVE: To evaluate the efficacy and tolerance of atovaquone used as long-term maintenance therapy in patients with toxoplasmic encephalitis and intolerant of conventional anti-Toxoplasma therapies. DESIGN: Uncontrolled open-label study of atovaquone given through an expanded access programme; statistical analysis
Relationship between foscarnet exposure, baseline cytomegalovirus (CMV) blood culture and the time to progression of CMV retinitis in HIV-positive patients.: AIDS. 1996 Sep;10(10):1113-9. Unique Identifier : AIDSLINE MED/97028615; Drusano GL; Aweeka F; Gambertoglio J; Jacobson M; Polis M; Lane HC; Eaton C; Martin-Munley S; Department of Medicine, Albany Medical College, New York 12208,; USA.; OBJECTIVE: To determine some of the factors influencing the time to progression of cytomegalovirus ( CMV ) retinitis among HIV-infected patients being treated with foscarnet. DESIGN: A retrospective analysis of two open-label P
The association between cigarette smoking and selected HIV-related medical conditions.: AIDS. 1996 Sep;10(10):1121-6. Unique Identifier : AIDSLINE MED/97028616; Conley LJ; Bush TJ; Buchbinder SP; Penley KA; Judson FN; Holmberg SD; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; OBJECTIVE: To clarify the effect of cigarette smoking on the development of conditions associated with HIV infection. DESIGN: Prospective and retrospective cohort study, with interview and examination twice a year since 1988. METHODS: Data on 516 HIV-infected men from cohorts of homosexual and bisexual men in San Fran
Rapid progression of HIV disease in children with cytomegalovirus DNAemia.: AIDS. 1996 Sep;10(10):1127-33. Unique Identifier : AIDSLINE MED/97028617; Nigro G; Krzysztofiak A; Gattinara GC; Mango T; Mazzocco M; Porcaro MA; Provvedi S; Booth JC; Paediatric Institute, La Sapienza University, Italy.; OBJECTIVE: In HIV-1-infected children, active cytomegalovirus ( CMV ) infection can cause severe clinical manifestations and accelerate progression of HIV disease. However, sufficient quantities of blood samples may not be avai
Risk factor analysis and serological diagnosis of HIV-1/HIV-2 infection in a Brazilian blood donor population: validation of the World Health Organization strategy for HIV testing.: AIDS. 1996 Sep;10(10):1135-40. Unique Identifier : AIDSLINE MED/97028618; Carvalho MB; Hamerschlak N; Vaz RS; Ferreira OC Jr; Hemotherapy Service, Hospital Israelita Albert Einstein, Sao; Paulo, Brazil.; OBJECTIVE: To determine the relative prevalence of HIV-1 and HIV-2 and to evaluate the World Health Organization testing strategy for HIV diagnosis in a low-risk population in Brazil . In addition, to assess risk factors for HIV infection. DESIGN: Se
The epidemiology of HIV-1 infection in Peru, 1986-1990.: AIDS. 1996 Sep;10(10):1141-5. Unique Identifier : AIDSLINE MED/97028619; McCarthy MC; Wignall FS; Sanchez J; Gotuzzo E; Alarcon J; Phillips I; Watts DM; Hyams KC; National Naval Medical Center, Bethesda, Maryland, USA.; OBJECTIVE: To determine the extent of the HIV-1 epidemic in Peru . DESIGN: Part of a national serosurvey in Peru. METHODS: Between January 1986 and December 1990, 140,976 serum samples were tested for HIV-1 antibody. RESULTS: HIV-1 a
Racial differences in rate of CD4 decline in HIV-1-infected homosexual men.: AIDS. 1996 Sep;10(10):1147-55. Unique Identifier : AIDSLINE MED/97028620; Easterbrook PJ; Farzadegan H; Hoover DR; Palenicek J; Chmiel JS; Kaslow RA; Saah AJ; Johns Hopkins School of Hygiene and Public Health, Baltimore,; Maryland, USA.; OBJECTIVE: To determine whether racial differences exist in the rate of CD4 lymphocyte decline in HIV-1-infected homosexual men. DESIGN: Prospective cohort study. STUDY POPULATION: Non-Hispanic white (n = 321) and black (n = 102) HIV-1-seropositive homosexual and bisexual men were recruited from the Baltimore/Washingt
Estimated rate of HIV-1-infectious but seronegative blood donations in Bangkok, Thailand.: AIDS. 1996 Sep;10(10):1157-62. Unique Identifier : AIDSLINE MED/97028621; Kitayaporn D; Kaewkungwal J; Bejrachandra S; Rungroung E; Chandanayingyong D; Mastro TD; Faculty of Tropical Medicine, Mahidol University, Bangkok,; Thailand.; OBJECTIVES: To determine HIV seroprevalence and incidence among various blood donor types, and to estimate the rate of window-period blood donations. DESIGN: Retrospective cohort from computerized donor records. METHODS: Records were analysed from all 60,483 donors (contributing 97,464 donor units) at a public univers
Behavioral effects of receiving HIV test results among injecting drug users in Puerto Rico.: AIDS. 1996 Sep;10(10):1163-8. Unique Identifier : AIDSLINE MED/97028622; Colon HM; Robles RR; Marrero CA; Reyes JC; Sahai H; Research Institute, Puerto Rico Mental Health and Anti-Addiction; Services Administration, San Juan, Puerto Rico, USA.; OBJECTIVES: To examine the influence of knowledge of HIV serostatus on changes in risk behaviors among injecting drug users (IDU). PROCEDURES: IDU were recruited through sampling conducted at street drug-selling areas. Of 374 participants, 88.8% consented to be HIV tested and returned for their test results, and 73.5%
Hepatitis B vaccination in HIV-1-infected children: double efficacy doubling the paediatric dose [letter]: AIDS. 1996 Sep;10(10):1169-70. Unique Identifier : AIDSLINE MED/97028623; Scolfaro C; Fiammengo P; Balbo L; Madon E; Tovo PA
Splenectomy and prognosis of HIV infection. Group d'Epidemiologie Clinique du SIDA en Aquitaine (GECSA) [letter]: AIDS. 1996 Sep;10(10):1170-2. Unique Identifier : AIDSLINE MED/97028624; Morlat P; Dequae-Merchadou L; Dabis F; Chene G; Salamon R; Beylot J
Antimony/interferon-gamma combination in the treatment of visceral leishmaniasis in AIDS [letter]: AIDS. 1996 Sep;10(10):1172-4. Unique Identifier : AIDSLINE MED/97028625; Kaplanski G; Buscaylet S; Penot-Ragon C; Durand JM; Soubeyrand J
Ocular and neurological complications of varicella zoster virus infection in a patient with AIDS [letter]: AIDS. 1996 Sep;10(10):1174-5. Unique Identifier : AIDSLINE MED/97028626; Meenken C; van den Horn GJ; Danner SA
Rapid epifluorescent technique to detect microsporidia [letter]: AIDS. 1996 Sep;10(10):1175-6. Unique Identifier : AIDSLINE MED/97028627; Berlin OG; Conteas CN; Porschen RK
Passive immunotherapy for rotavirus-induced diarrhoea in children with HIV infection [letter]: AIDS. 1996 Sep;10(10):1176-8. Unique Identifier : AIDSLINE MED/97028628; Guarino A; Russo S; Castaldo A; Spagnuolo MI; Tarallo L; Rubino A
Presence of Chlamydia pneumoniae strain TWAR in bronchial secretions collected from HIV-positive and negative patients: preliminary data [letter]: AIDS. 1996 Sep;10(10):1178-9. Unique Identifier : AIDSLINE MED/97028629; Scaglione F; Maccarinelli G; Fasan M; Grisetti R; Riva P; D'Adda D; Ratti I
Disseminated papular eruption caused by Serratia marcescens: a new cutaneous manifestation in HIV-positive patients [letter]: AIDS. 1996 Sep;10(10):1179-80. Unique Identifier : AIDSLINE MED/97028630; Munoz-Perez MA; Rodriguez-Pichardo A; Camacho F
Confronting the emerging HIV epidemic in Vietnam: social context and preliminary data on physician preparedness [letter]: AIDS. 1996 Sep;10(10):1180-1. Unique Identifier : AIDSLINE MED/97028631; Ha TP; Ickovics JR
Sensitivity of HIV-1 DNA polymerase chain reaction in the neonatal period. The New York City Perinatal HIV Transmission Collaborative Study Group [letter]: AIDS. 1996 Sep;10(10):1181-2. Unique Identifier : AIDSLINE MED/97028632; Kuhn L; Abrams EJ; Chinchilla M; Tsai WY; Thea DM
Differential tropism of HIV-1 isolates for distinct thymocyte subsets in vitro.: AIDS. 1996 Jun;10(7):F9-16. Unique Identifier : AIDSLINE MED/96399347; Uittenbogaart CH; Anisman DJ; Jamieson BD; Kitchen S; Schmid I; Zack JA; Hays EF; Department of Pediatrics, University of California Los Angeles; School of Medicine, USA.; OBJECTIVE: Understanding the interaction between HIV and developing thymocytes is crucial in determining how HIV infection perturbs the immune system. We determined which thymocyte subsets can harbor and express HIV. DESIGN: HIV expression in mature and immature thymocytes obtained from surgical specimens from non-inf
Lessons from the second AIDS virus, HIV-2 [editorial]: AIDS. 1996 Jun;10(7):689-99. Unique Identifier : AIDSLINE MED/96399348; Marlink R
Promotion of tumour metastases and induction of angiogenesis by native HIV-1 Tat protein from BK virus/tat transgenic mice.: AIDS. 1996 Jun;10(7):701-10. Unique Identifier : AIDSLINE MED/96399349; Corallini A; Campioni D; Rossi C; Albini A; Possati L; Rusnati M; Gazzanelli G; Benelli R; Masiello L; Sparacciari V; Presta M; Mannello F; Fontanini G; Barbanti-Brodano G; Institute of Microbiology, University of Ferrara, Italy.; OBJECTIVE: To characterize the T53 cell line and its clones derived from an adenocarcinoma of BK virus (BKV)/tat transgenic mice and to establish the role of native Tat in tumorigenicity, induction of metastases and angiogenesis. DESIGN AND METHODS: Tat was quantified by flow cytometry and chloramphenicol acetyltransf
HIV-1 proviral DNA polymerase chain reaction detection in chorionic villi after exclusion of maternal contamination by variable number of tandem repeats analysis.: AIDS. 1996 Jun;10(7):711-5. Unique Identifier : AIDSLINE MED/96399350; De Andreis C; Simoni G; Rossella F; Castagna C; Pesenti E; Porta G; Colucci G; Giuntelli S; Pardi G; Semprini AE; Department of Obstetrics and Gynaecology, University of Milan; Medical School, Italy.; OBJECTIVE: The study of the placental HIV infection in cases of seropositive pregnant women after exclusion of maternal contamination of chorionic villi samples by variable number of tandem repeats (VNTR) analysis. METHODS: We studied 30 HIV-positive women: 17 terminated their pregnancy (11 in the first trimester and
Thymocyte and thymic microenvironment alterations during a systemic HIV infection in a severe combined immunodeficient mouse model.: AIDS. 1996 Jun;10(7):717-27. Unique Identifier : AIDSLINE MED/96399351; Autran B; Guiet P; Raphael M; Grandadam M; Agut H; Candotti D; Grenot P; Puech F; Debre P; Cesbron JY; Laboratory of Cellular Immunology, Unite de Recherche Associee,; Centre National de Recherche Scientifique (CNRS) 625, Paris,; France.; OBJECTIVE: A new model for systemic and multifocal HIV-1 infection was developed in severe combined immunodeficient (SCID) mice to study the alterations of thymocytes and of the thymic microenvironment that occur during a disseminated HIV infection. DESIGN AND METHODS: We grafted SCID mice with the classical human fet
Skewing of the T-cell receptor repertoire in the lung of patients with HIV-1 infection.: AIDS. 1996 Jun;10(7):729-37. Unique Identifier : AIDSLINE MED/96399352; Trentin L; Zambello R; Facco M; Sancetta R; Cerutti A; Milani A; Tassinari C; Crivellaro C; Cipriani A; Agostini C; Semenzato G; Department of Clinical and Experimental Medicine, Padua; University School of Medicine, Padova, Italy.; OBJECTIVES: A bias of the use of T-cell receptor (TCR) V beta regions has been reported both in peripheral blood and in several tissues in patients with AIDS, including lymph nodes, spleen and salivary glands. Although the disease is frequently characterized by an infiltration of T cells in the lung interstitium, no i
Malabsorption and wasting in AIDS patients with microsporidia and pathogen-negative diarrhea.: AIDS. 1996 Jun;10(7):739-44. Unique Identifier : AIDSLINE MED/96399353; Lambl BB; Federman M; Pleskow D; Wanke CA; Division of Infectious Diseases, New England Deaconess Hospital,; Boston, MA 02215, USA.; OBJECTIVE: To define the clinical syndrome, nutritional status and malabsorptive status in patients with HIV and chronic diarrhea and either microsporidia or no identified pathogen. PATIENTS: HIV-positive patients from an urban, hospital-based infectious disease clinic with chronic diarrhea who had undergone exhaustiv
Safety and efficacy of nandrolone decanoate for treatment of wasting in patients with HIV infection.: AIDS. 1996 Jun;10(7):745-52. Unique Identifier : AIDSLINE MED/96399354; Gold J; High HA; Li Y; Michelmore H; Bodsworth NJ; Finlayson R; Furner VL; Allen BJ; Oliver CJ; Albion Street Centre, Prince of Wales Hospital, Sydney,; Australia.; OBJECTIVE: To evaluate the safety and efficacy of the anabolic steroid, nandrolone decanoate (Deca Durabolin) in patients with HIV wasting who are resistant to nutritional intervention. DESIGN: A 16-week open trial with subjects who had lost 5-15% of their usual body weight. SETTING: HIV/AIDS specialist ambulatory car
Phase II study of liposomal encapsulated daunorubicin in the treatment of AIDS-associated mucocutaneous Kaposi's sarcoma.: AIDS. 1996 Jun;10(7):753-7. Unique Identifier : AIDSLINE MED/96399355; Girard PM; Bouchaud O; Goetschel A; Mukwaya G; Eestermans G; Ross M; Rozenbaum W; Saimot AG; Rothschild Hospital, Paris, France.; OBJECTIVE: To evaluate the efficacy and safety of liposomal encapsulated daunorubicin (DaunoXome) in the treatment of AIDS-associated mucocutaneous Kaposi s sarcoma. DESIGN: A Phase II, multicentre, European, non-comparative, open study to assess the use of DaunoXome in patients with no prior anthracycline chemotherap
The distribution of immunocompetent cells in the genital tract of HIV-positive women.: AIDS. 1996 Jun;10(7):759-64. Unique Identifier : AIDSLINE MED/96399356; Olaitan A; Johnson MA; MacLean A; Poulter LW; Department of Gynaecology and HIV Medicine, Royal Free Hospital; and Medical School, London, UK.; OBJECTIVE: To study the distribution of immunocompetent cells in the female lower genital tract and to determine whether it is altered in HIV infection. METHODS: Colposcopically directed cervical biopsies were taken in the premenstrual phase of 10 HIV-positive women with sexually acquired infection, and matched HIV-ne
Patterns and trends in clinically recognized HIV seroconversions among all newly diagnosed HIV-infected homo-/bisexual men in Denmark, 1991-1994.: AIDS. 1996 Jun;10(7):765-70. Unique Identifier : AIDSLINE MED/96399357; Smith E; Jensen L; Wachmann CH; Department of Epidemiology, Statens Seruminstitut, Copenhagen,; Denmark.; OBJECTIVE: To analyse patterns and trends in recently acquired HIV infections among newly diagnosed homo-/bisexual men. DESIGN AND METHODS: All newly diagnosed HIV-positive homo-/bisexual men reported to the mandatory national HIV reporting system in
No aggregate change in homosexual HIV risk behaviour among gay men attending the Gay Pride festivals, United Kingdom, 1993-1995.: AIDS. 1996 Jun;10(7):771-4. Unique Identifier : AIDSLINE MED/96399358; Hickson FC; Reid DS; Davies PM; Weatherburn P; Beardsell S; Keogh PG; Sigma Research, University of Portsmouth, Portsmouth and London,; England, UK.; OBJECTIVES: To examine aggregate changes in homosexual HIV risk-taking among gay men attending the Gay Pride festival in the United Kingdom over a 3-year period during which HIV prevention activity targeted at this population increased considerably. DESIGN: Three cross-sectional self-c
The validity of self-reported health-care utilization by AIDS patients.: AIDS. 1996 Jun;10(7):775-83. Unique Identifier : AIDSLINE MED/96399359; Weissman JS; Levin K; Chasan-Taber S; Massagli MP; Seage GR 3rd; Scampini L; Department of Health Care Policy, Harvard Medical School, Boston,; Massachusetts 02115, USA.; OBJECTIVES: To examine the validity of self-reported health-care utilization among persons with AIDS. DESIGN: A comparison of survey data with information collected from medical and financial records. METHODS: Personal interviews provided information on utilization within a 4-month period for inpatient admissions (n =
Epidemiological surveillance of leishmaniasis in HIV-1-infected individuals in Italy.: AIDS. 1996 Jun;10(7):785-91. Unique Identifier : AIDSLINE MED/96399360; Gradoni L; Scalone A; Gramiccia M; Troiani M; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.; OBJECTIVE: To actively detect leishmaniasis in HIV-1-infected individuals in Italy , to describe the epidemiological features of the disease in these patients, and to compare them with epidemiological features of leishmaniasis in HIV-negative patients. DESIGN: Retrospective and prosp
HIV-1 p24 Gag-specific cytotoxic T-lymphocyte responses in mice [letter]: AIDS. 1996 Jun;10(7):793-4. Unique Identifier : AIDSLINE MED/96399361; Doe B; Walker CM
Lack of association of low testosterone with HIV-associated Kaposi's sarcoma [letter]: AIDS. 1996 Jun;10(7):794-5. Unique Identifier : AIDSLINE MED/96399362; Falutz J
Development of zidovudine-resistant HIV genotypes following postnatal prophylaxis in a perinatally infected infant [letter]: AIDS. 1996 Jun;10(7):795-7. Unique Identifier : AIDSLINE MED/96399363; Srinivas RV; Holden WT; Su T; Flynn PM
Prostate cancer in HIV infection [letter]: AIDS. 1996 Jun;10(7):797-8. Unique Identifier : AIDSLINE MED/96399364; Schwartz JD; Prince D
Survival in a cohort of 1205 AIDS patients from Milan [letter]: AIDS. 1996 Jun;10(7):798-9. Unique Identifier : AIDSLINE MED/96399365; d'Arminio Monforte A; Mainini F; Formenti T; Moscatelli GC; Sansone L; Testa L; Bini T; Moroni M
Diagnosis of disseminated toxoplasmosis using a peripheral blood smear [letter]: AIDS. 1996 Jun;10(7):799-800. Unique Identifier : AIDSLINE MED/96399366; Albrecht H; Sobottka I; Stellbrink HJ; van Lunzen J; Greten H
Kinetics of viral clearance in plasma, peripheral blood mononuclear cells and lymph nodes [letter]: AIDS. 1996 Jun;10(7):801-2. Unique Identifier : AIDSLINE MED/96399367; Lafeuillade A; Djediouane A; Poggi C; Profizi N; Costes O; Tamalet C
No evidence for the role of transforming growth factor in intestinal tract pathology of HIV-infected patients [letter]: AIDS. 1996 Jun;10(7):802. Unique Identifier : AIDSLINE MED/96399368; Snijders F
Cytomegalovirus infection in the genital tract of HIV-seropositive women [letter]: AIDS. 1996 Jun;10(7):802-3. Unique Identifier : AIDSLINE MED/96399369; Wales NM; Nordin AJ; Newell AN; Smith JR; Barton SE; Nelson MR
Detection of intracellular p24-positive macrophages in gingival crevicular fluid from periodontal lesions of stage IV AIDS patients [letter]: AIDS. 1996 Jun;10(7):804-5. Unique Identifier : AIDSLINE MED/96399370; Suzuki T; Yoshie H; Jeannel D; Tortevoye P; Fournier S; Dupont B; de The G; Hara K
Prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users in south-eastern Italy [letter]: AIDS. 1996 Jun;10(7):805-6. Unique Identifier : AIDSLINE MED/96399371; Angarano G; Monno L; Fiore JR; Fracasso C; La Grasta L; Romanelli C
High incidence and aggressive growth of non-AIDS-defining cancers among AIDS patients in Oslo.: APMIS. 1996 Oct;104(10):729-33. Unique Identifier : AIDSLINE MED/97135065; Goplen AK; Liestol K; Dunlop O; Strom EH; Bruun JN; Maehlen J; Department of Pathology, Ullev~al University Hospital, Oslo,; Norway.; The spectrum of cancers advanced by AIDS is disputed. To supplement the register-based investigations, we have studied the occurrence of non-AIDS-defining malignancies in a closely followed population of AIDS patients. The population comprises 255 patients fulfilling CDC s clinical AIDS definition, representing 91% of
Challenges faced by the HIV health services planning council in Oakland, California, 1991-1994.: Am J Prev Med. 1996 Jul-Aug;12(4 Suppl):26-32. Unique Identifier : AIDSLINE MED/97028688; Kieler BW; Rundall TG; Saporta I; Sussman PC; Keilch R; Warren N; Black S; Brinkley B; Barney L; Schools of Public Health, University of California at Berkeley,; USA.; This study reports the findings of a case study of the health services planning council established in the Oakland, California, eligible metropolitan area (the Oakland EMA) under Title I of the Ryan White Comprehensive AIDS Resources Emergency Act of 1990 (the CARE Act). We gathered primary data through observation of
Stabilizing the HIV/AIDS workforce: lessons from the New York City experience.: Am J Prev Med. 1996 Jul-Aug;12(4 Suppl):39-46. Unique Identifier : AIDSLINE MED/97028690; Healton C; Haviland L; Weinberg G; Messeri P; Aidala A; Stein G; Jessop D; Jetter D; Columbia University School of Public Health, New York, NY 10032,; USA.; The Ryan White Title I Personnel Needs Study described here is an evaluation of the human resource needs of HIV/AIDS service agencies in New York City. The research presented here was conducted in collaboration with researchers from the Medical and Health Research Association and the New York City Department of Health
The impact of patient education about the effect of zidovudine on HIV perinatal transmission: knowledge gain, attitudes, and behavioral intent among women with and at risk of HIV.: Am J Prev Med. 1996 Jul-Aug;12(4 Suppl):47-52. Unique Identifier : AIDSLINE MED/97028691; Healton C; Taylor S; Burr C; Dumois A; Loewenstein N; Kaye J; Division of Sociomedical Sciences, Columbia School of Public; Health, Columbia University, New York, New York 10032, USA.; The termination of the perinatal HIV transmission trial, ACTG 076, by the Data Safety and Monitoring Board in February 1994 because of the efficacy of zidovudine (ZDV) in substantially reducing maternal-infant HIV transmission has created a considerable need for efficacious patient education approaches and materials f
A balancing act: the tension between case-finding and primary prevention strategies in New York State's voluntary HIV counseling and testing program in women's health care settings.: Am J Prev Med. 1996 Jul-Aug;12(4 Suppl):53-60. Unique Identifier : AIDSLINE MED/97028692; Healton C; Messeri P; Abramson D; Howard J; Sorin MD; Bayer R; Sociomedical Sciences Division, Columbia School of Public Health,; Columbia University, New York, NY 10032, USA.; This study sought (1) to identify factors that influence women s willingness to accept voluntary HIV counseling and testing at New York State Family Planning Programs (FPPs) and Prenatal Care Assistance Programs (PCAPs) and (2) to evaluate the effectiveness of such a voluntary counseling and testing program. Telephone
Gender differences in HIV-related self-reported knowledge, attitudes, and behaviors among college students.: Am J Prev Med. 1996 Jul-Aug;12(4 Suppl):61-6. Unique Identifier : AIDSLINE MED/97028693; Dekin B; New York State University at Albany, USA.; A survey of 265 college students was conducted to determine HIV-related knowledge, attitudes, behavior, and perceived self-efficacy with regard to engaging in HIV-protective behaviors. A self-administered 52-item survey was completed by 265 college students (60% response rate). Resident advisors in college dormitories
[Vasculitis caused by Pseudomonas: a case report]: Acta Otorrinolaringol Esp. 1996 Sep-Oct;47(5):404-6. Unique Identifier : AIDSLINE MED/97095476; Escamilla Y; Gutierrez M; Martinez T; Bodoque M; Gomez JM; Moreno A; Hospital General Gregorio Maranon, Madrid.; Pseudomona vasculitis is an exceptional disease. Only a few cases have been reported, non with oropharyngeal involvement. The case of a 30-year-old, HIV-positive man who suddenly developed septicemia and necrotizing lesions with tissue destruction of the oropharynx is reported. Histological study confirmed vasculitis.
The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1203-7. Unique Identifier : AIDSLINE MED/97024613; Paxton WA; Dragic T; Koup RA; Moore JP; Aaron Diamond AIDS Research Center, Rockefeller University, New; York, New York 10016, USA.
HIV type 1 glycoprotein 120 amplifies tumor necrosis factor-induced NF-kappa B activation in Jurkat cells.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1209-16. Unique Identifier : AIDSLINE MED/97024614; Shatrov VA; Ratter F; Gruber A; Droge W; Lehmann V; Division of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; This article demonstrates that human immunodeficiency virus type 1 (HIV-1) gp120 amplifies the activity of tumor necrosis factor alpha (TNF-alpha), a cytokine that stimulates HIV-1 replication through activation of NF-kappa B. In CD4-positive Jurkat cells, gp120 potentiates TNF-induced NF-kappa B activation. TNF-media
HTLV type IIIB infection of human thymic epithelial cells: viral expression correlates with the induction of NF-kappa B-binding activity in cells activated by cell adhesion.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1217-25. Unique Identifier : AIDSLINE MED/97024615; Ramarli D; Reina S; Merola M; Scupoli MT; Poffe O; Riviera AP; Brentegani M; Fiorini E; Vella A; Varnier O; Tridente G; Instituto di Immunologia e Malattie Infettive, Universita di; Verona, Italy.; Productive infection by the LAV strain has been demonstrated in T cell precursors at different stages of intrathymic development, while viral replication in thymic epithelial cells is still controversial. In this article we show that epithelial cell cultures derived from the medullary component of normal thymus are in
The inhibition of HIV replication in monocytes by interleukin 10 is linked to inhibition of cell differentiation.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1227-35. Unique Identifier : AIDSLINE MED/97024616; Chang J; Naif HM; Li S; Jozwiak R; Ho-Shon M; Cunningham AL; Department of Virology, Westmead Hospital, NSW, Australia.; The effect of exogenous recombinant interleukin 10 on the replication of low-passage HIV-1 strains in blood-derived monocytes and monocyte-derived-macrophages (MDMs) was examined at various stages of cell maturation after adherence to the plastic substrate. Interleukin 10 inhibited extracellular production of HIV-1 to
Inhibition of human immunodeficiency virus replication in differentiating monocytes by interleukin 10 occurs in parallel with inhibition of cellular RNA expression.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1237-45. Unique Identifier : AIDSLINE MED/97024617; Naif HM; Chang J; Ho-Shon M; Li S; Cunningham AL; Department of Virology, Westmead Hospital, University of Sydney,; Australia.; The mechanism of inhibition of HIVBa-L replication by interleukin 10 (IL-10) in primary monocytes and macrophages at various stages of maturation was investigated using semiquantitative PCR for reverse-transcribed HIV DNA, and Northern hybridization for HIV mRNA expression in comparison with extracellular p24 antigen.
HIV type 1 phenotype correlates with the stage of infection in vertically infected children.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1247-53. Unique Identifier : AIDSLINE MED/97024618; Balotta C; Vigano A; Riva C; Colombo MC; Salvaggio A; de Pasquale MP; Crupi L; Papagno L; Galli M; Moroni M; Principi N; Clinica delle Malattie Infettive, University of Milan, Italy.; A cohort of 39 vertically infected children (class N, A, B, and C of the CDC HIV classification for pediatric infection) was studied by virus isolation and non-syncytium inducing (NSI)/syncytium inducing (SI) HIV-1 phenotype evaluation. The HIV-1 isolates were recovered from PBMCs and the MT-2 cell line was used to pe
Virologic and immunologic markers of disease progression in pediatric HIV infection.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1255-62. Unique Identifier : AIDSLINE MED/97024619; Vigano A; Balotta C; Trabattoni D; Salvaggio A; Riva C; Bricalli D; Crupi L; Colombo MC; Principi N; Galli M; Clerici M; Cattedra di Pediatria IV, Ospedale L. Sacco, Milan, Italy.; Correlates of progression of human immunodeficiency virus (HIV) infection to AIDS include the reduction in CD4+ T cells and the emergence of syncytium-inducing (SI) HIV variants. It has been suggested that progressive defects in interleukin 2 ( IL-2 ), IL-12, and IFN- ga
Cytokine mRNA expression in mononuclear cells from different tissues during acute SIVmac251 infection of macaques.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1263-72. Unique Identifier : AIDSLINE MED/97024620; Cheret A; Le Grand R; Caufour P; Dereuddre-Bosquet N; Matheux F; Neildez O; Theodoro F; Maestrali N; Benveniste O; Vaslin B; Dormont D; Service de Neurovirologie, Centre de Recherches du Service de; Sante des Armees Emile Parde, Commissariat a l'Energie; Atomique, DSV/DRM, Institut Paris-Sud sur les Cytokines, Fontenay; aux Roses, France.; We used semiquantitative RT-PCR to monitor the expression of mRNA encoding cytokines (IL-1 beta, IL-6, TNF-alpha, and IL-10) and IFN-gamma in fresh isolated peripheral blood mononuclear cells (PBMCs), lymph node mononuclear cells (LNMCs), and mononuclear cells obtained after bronchoalveolar lavages (BALMCs), of four c
The relationship between the interferon alpha response and viral burden in primary SIV infection.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1273-8. Unique Identifier : AIDSLINE MED/97024621; Khatissian E; Tovey MG; Cumont MC; Monceaux V; Lebon P; Montagnier L; Hurtrel B; Chakrabarti L; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; The interferon alpha (IFN-alpha) response of rhesus macaques was investigated during primary infection with pathogenic and attenuated simian immunodeficiency virus (SIV). IFN-alpha was detected in the serum of animals as early as day 4 after inoculation of SIVmac251, but remained barely detected in animals infected wi
Diversity of antibody binding to V3 peptides representing consensus sequences of HIV type 1 genotypes A to E: an approach for HIV type 1 serological subtyping.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1279-89. Unique Identifier : AIDSLINE MED/97024622; Barin F; Lahbabi Y; Buzelay L; Lejeune B; Baillou-Beaufils A; Denis F; Mathiot C; M'Boup S; Vithayasai V; Dietrich U; Goudeau A; Laboratoire de Virologie, URA CNRS 1334, Universite Francois; Rabelais, Tours, France.; We investigated whether V3-binding assays might be useful to analyze human immunodeficiency virus type 1 (HIV-1) variants in different geographic regions. We showed that strong cross-reactivity between subtype-specific V3 peptides is almost inevitable in standard indirect enzyme-linked immunosorbent assays (EIA), impa
Lack of dual HIV infection in a transfusion recipient exposed to two seropositive blood components.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1291-5. Unique Identifier : AIDSLINE +; Diaz RS; Sabino EC; Mayer A; deOliveria CF; Mosley JW; Busch MP; Irwin Memorial Blood Centers, San Francisco, California 94118,; USA.
Fluctuating diversity in the HTLV-IIIB virus stock: implications for neutralization and challenge experiments.: AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1297-9. Unique Identifier : AIDSLINE +; Lockey TD; Slobod KS; Rencher SD; Srinivas RV; Hurwitz JL; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee 38101, USA.
Florida dental AIDS mystery [letter]: Br Dent J. 1996 Mar 9;180(5):170. Unique Identifier : AIDSLINE MED/97021259; Hardie J
Deadly human parasite discovered.: Oncology (Huntingt). 1996 Aug;10(8):1133, 1139. Unique Identifier : AIDSLINE MED/97023596
Nutritional care of the patient with HIV/AIDS.: Nurs Stand. 1996 Dec 11;11(12):44-6. Unique Identifier : AIDSLINE MED/97129745; Bacon P; Nutrition and diet plan an important role in regulating the immune system. People with HIV disease are prone to weight loss for a number of reasons, although this is not inevitable. The aim of nutritional therapy is to preserve body weight, particularly lean body mass.
Successful treatment of crusted (Norwegian) scabies with ivermectin in two patients with human immunodeficiency virus infection [letter]: Br J Dermatol. 1996 Sep;135(3):494-5. Unique Identifier : AIDSLINE MED/97106710; DelGiudice P; Carles M; Couppie P; Bernard E; Lacour JP; Marty P; Pradinaud R; Ortonne JP; Dellamonica P; LeFichoux Y
Papuloerythroderma of Ofuji in a HIV-infected patient [letter]: Br J Dermatol. 1996 Sep;135(3):500-1. Unique Identifier : AIDSLINE MED/97106716; Lonnee ER; Toonstra J; van der Putte SC; van Weelden H; van Vloten WA
Non-HIV-related Kaposi's sarcoma suppressed by dapsone.: Br J Dermatol. 1996 Nov;135(5):813-4. Unique Identifier : AIDSLINE MED/97132234; de Haas ER; de Wit RF; van Vloten WA; Department of Dermatology, University Hospital Utrecht, The; Netherlands.
SPC3, a V3 loop-derived synthetic peptide inhibitor of HIV-1 infection, binds to cell surface glycosphingolipids.: Biochemistry. 1996 Dec 10;35(49):15663-71. Unique Identifier : AIDSLINE MED/97121263; Delezay O; Hammache D; Fantini J; Yahi N; Laboratoire de Biochimie et Biologie de la Nutrition, URA-CNRS; 1820, Faculte des Sciences de St Jerome, Marseille, France.; Synthetic multibranched peptides derived from the V3 domain of human immunodeficiency virus type 1 (HIV-1) gp120 inhibit HIV-1 entry into CD4+ and CD4- cells by two distinct mechanisms: competitive inhibition of HIV-1 binding to CD4-/GalCer+ colon cells and postbinding inhibition of HIV-1 fusion with CD4+ lymphocytes.
Investigations of cytokine production in whole blood cultures of paranoid and residual schizophrenic patients.: Eur Arch Psychiatry Clin Neurosci. 1996;246(5):279-84. Unique Identifier : AIDSLINE MED/97016372; Wilke I; Arolt V; Rothermundt M; Weitzsch C; Hornberg M; Kirchner H; Institute of Immunology and Transfusion Medicine, University of; Lubeck School of Medicine, Germany.; In an attempt to define potential immunological dysfunctions in schizophrenia, we determined the production of interleukin-2 ( IL-2 ), interleukin-4 (IL-4), interferon-gamma (IFN-gamma), and soluble IL-2 receptor (sIL-2R) in a whole-blood assay after stimulation with phy
Supporting children in need through a community-based orphan visiting programme.: AIDS Care. 1996 Aug;8(4):389-403. Unique Identifier : AIDSLINE MED/97017310; Foster G; Makufa C; Drew R; Kambeu S; Saurombe K; Paediatric Department, Mutare Provincial Hospital, Harare,; Zimbabwe. gfoster@+healthnet.zw; There is an urgent need for programmes to be established to support the growing number of orphans in countries severely affected by AIDS. Most orphans are being cared for by extended families under difficult circumstances. Few descriptions of community-based orphan support programmes exist. We describe one such progra
Patrons of the sex industry: perceptions of risk.: AIDS Care. 1996 Aug;8(4):405-16. Unique Identifier : AIDSLINE MED/97017311; Plumridge EW; Chetwynd SJ; Reed A; Gifford SJ; Department of Public Health and General Practice, Christchurch; School of Medicine, New Zealand.; This paper reports on an in-depth study of how men who buy sex construe risk in relation to their sexual activities. Twenty men were contacted in a massage parlour, four more through sex workers or newspaper advertisements. In-depth, face-to-face interviews were recorded. Two main discourses were articulated by the me
Segmentation of heterosexual prostitution into various forms: a barrier to the potential transmission of HIV.: AIDS Care. 1996 Aug;8(4):417-31. Unique Identifier : AIDSLINE MED/97017312; de Graaf R; van Zessen G; Vanwesenbeeck I; Straver CJ; Visser JH; Netherlands Institute of Social Sexological Research, Utrecht,; The Netherlands.; The results of an earlier Dutch study on prostitutes clients, interviewed face-to-face, were cross-validated by means of telephone interviews, which both guaranteed anonymity and produced a larger sample of respondents (n = 559). Depending on their preference and financial resources, they had visited different types
Depression and use of mental health services among HIV-infected men.: AIDS Care. 1996 Aug;8(4):433-42. Unique Identifier : AIDSLINE MED/97017313; Katz MH; Douglas JM Jr; Bolan GA; Marx R; Sweat M; Park MS; Buchbinder SP; Department of Public Health, San Francisco, California, USA.; Depression is a serious, common, and treatable condition among HIV-infected persons. We examined the prevalence and predictors of depression and use of mental health services among 475 HIV-infected men without AIDS. Participants were drawn from three sites in San Francisco and Denver that did not provide ongoing medic
Sexual debut and predictors of condom use among secondary school students in Arusha, Tanzania.: AIDS Care. 1996 Aug;8(4):443-52. Unique Identifier : AIDSLINE MED/97017314; Lugoe WL; Klepp KI; Skutle A; Department of Educational Psychology, Faculty of Education,; University of Dar es Salaam, Tanzania.; A cross-sectional survey was conducted using interviews among 852 students attending seven secondary schools in the Arusha region, Northern Tanzania , to predict determinants of sexual debut and recent condom use among students. Schools were sampled according to location, school s
College students' perceptions of the prevalence of risky sexual behaviour.: AIDS Care. 1996 Aug;8(4):453-66. Unique Identifier : AIDSLINE MED/97017315; Seal DW; Agostinelli G; HIV Center for Clinical and Behavioral Studies, NYSPI, New York,; USA.; In contrast to previous research which has largely focused on students perceptions of other students risk for contracting HIV/STDs, this study assessed single heterosexual college students (96 men, 121 women) perceptions of the prevalence of different sexual behaviours which increase a person s risk for HIV/STD inf
Community service needs of people with HIV infection in London.: AIDS Care. 1996 Aug;8(4):467-78. Unique Identifier : AIDSLINE MED/97017316; Petrou S; Dooley M; Whitaker L; Beck E; Kupek E; Wadsworth J; Miller D; Renton A; Academic Department of Public Health, St Mary's Hospital Medical; School, London, UK.; The objectives of this study were to describe the expressed needs for community services of HIV-infected individuals by disease stage, gender and transmission category and the barriers which prevent the receipt of such services. Structured interviewer-administered questionnaires concerning a 6-month retrospective peri
Nurses' intentions to provide home care: the impact of AIDS and homosexuality.: AIDS Care. 1996 Aug;8(4):479-88. Unique Identifier : AIDSLINE MED/97017317; Vermette L; Godin G; Centre local de services communautaires, Sainte-Foy-Sillery,; Quebec, Canada.; The purpose of this experimental study was to identify key factors influencing the intention of nurses (n = 102) to provide care at home to AIDS or leukaemia patients, homosexual or heterosexual. Ajzen s theory of planned behaviour with the addition of personal normative belief borrowed from Triandis s theory defined
A primary health care service for Glasgow street sex workers--6 years experience of the "drop-in centre', 1989-1994.: AIDS Care. 1996 Aug;8(4):489-97. Unique Identifier : AIDSLINE MED/97017318; Carr S; Goldberg DJ; Elliott L; Green S; Mackie C; Gruer L; Family Planning and Sexual Health Centre, Glasgow, UK.; In Glasgow, a health and social care centre opened in 1988 principally to facilitate HIV prevention among street prostitutes, most of whom are injecting drug users. During 1992 to 1994, 551 women made 17,554 visits to the medical room which is functional 5 nights per week. The mean age of the sex workers was 26 years
WHO global AIDS statistics.: AIDS Care. 1996 Aug;8(4):501. Unique Identifier : AIDSLINE MED/97017319
[Digestive cytomegalovirus disease in AIDS patients]: Enferm Infecc Microbiol Clin. 1996 Aug-Sep;14(7):411-5. Unique Identifier : AIDSLINE MED/97080072; Barbera JR; Capdevila JA; Garcia-Quintana AM; Calico I; Allende H; Ruiz I; Ocana I; Pahissa A; Unidad de Enfermedades Infecciosas, Hospital General Vall; d'Hebron, Barcelona.; BACKGROUND: In this paper we study the digestive manifestations of cytomegalovirus ( CMV ) in AIDS patients. Also, we evaluate the antiviral treatment and the necessity of maintenance therapy. METHODS: Retrospective review of m
[Gynecological complications in HIV-positive women]: Enferm Infecc Microbiol Clin. 1996 Aug-Sep;14(7):444-6. Unique Identifier : AIDSLINE MED/97080079; del Amo J; Palacios S; Academic Department of Genitourinary Medicine, University College; of London-Medical School.
[Pneumonia caused by measles in a pregnant woman with HIV antibodies. Response to treatment with immunoglobulins (letter)]: Enferm Infecc Microbiol Clin. 1996 Aug-Sep;14(7):456-7. Unique Identifier : AIDSLINE MED/97080088; Carmena J; Tornero C; Salcedo M; Perpinan J; Pons E
Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope.: Hum Gene Ther. 1996 Aug 1;7(12):1415-22. Unique Identifier : AIDSLINE MED/97001208; Lam JS; Reeves ME; Cowherd R; Rosenberg SA; Hwu P; Surgery Branch, National Cancer Institute, National Institutes of; Health, Bethesda, MD 20892, USA.; Gene-modified lymphocytes have a potential role in the therapy of cancer, infectious diseases, and genetic disorders of the immune system. Current gene therapy protocols involving gene transfer into lymphocytes utilize retroviruses with amphotropic envelope proteins. However, transduction efficiencies in lymphocytes u
Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig.: Hum Gene Ther. 1996 Aug 1;7(12):1455-63. Unique Identifier : AIDSLINE MED/97001213; Guerette B; Vilquin JT; Gingras M; Gravel C; Wood KJ; Tremblay JP; Centre de recherche en Neurobiologie, Universite Laval, Quebec; City, Canada.; The therapeutic potential of adenovirus-mediated gene transfer using first-generation vectors is severely limited by the fact that only transient expression is achievable in immunocompetent animals. The loss in transgene expression can be attributed at least in part to the appearance of detrimental immune responses di
Radioimmunoassay for ziovudine in rat placenta and fetus.: J Pharm Biomed Anal. 1996 May;14(7):855-60. Unique Identifier : AIDSLINE MED/96405570; Huang CS; Boudinot FD; Feldman S; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602-2351, USA.
Ontogeny of circulating leucocytes in the fetal guinea pig.: Biol Neonate. 1996;70(2):108-15. Unique Identifier : AIDSLINE MED/97017813; Jones AC; Burdge GC; Warner JA; Postle AD; Warner JO; Faculty of Medicine, University of Southampton, Southampton; General Hospital, UK.; The ontogeny of leucocytes in the fetal guinea pig was investigated. The total leucocyte concentration increased between days 40 and 56, but thereafter was unchanged at term (day 68). T and B lymphocytes were detected on day 56 and at term, and while T cell concentrations remained constant between day 56 and term, the
Prevention of perinatal transmission of human immunodeficiency virus: a progress report 2 years after completion of AIDS Clinical Trials Group trial 076.: Clin Infect Dis. 1996 Sep;23(3):438-41. Unique Identifier : AIDSLINE MED/97034104; Wilfert CM; Department of Pediatrics, Duke University Medical Center, Durham,; North Carolina 27710, USA.; In this AIDS commentary, Dr. Wilfert has reviewed the American experience with vertical transmission of human immunodeficiency virus type 1 (HIV-1) since the closing of the 076 trial performed by the AIDS Clinical Trials Group in February 1994. The news generally is good; the rate of transmission from mother to child
Increased risk of infection with human immunodeficiency virus type 1 among uncircumcised men presenting with genital ulcer disease in Kenya.: Clin Infect Dis. 1996 Sep;23(3):449-53. Unique Identifier : AIDSLINE MED/97034106; Tyndall MW; Ronald AR; Agoki E; Malisa W; Bwayo JJ; Ndinya-Achola JO; Moses S; Plummer FA; Department of Medical Microbiology, University of Nairobi, Kenya.; The factors responsible for the explosive spread of human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa continue to be identified and debated. One of the most controversial factors has been male circumcision. This cross-sectional study was conducted to measure the association between circumcision status
Prominent osseous and unusual dermatologic manifestations of early syphilis in two patients with discordant serological statuses for human immunodeficiency virus infection.: Clin Infect Dis. 1996 Sep;23(3):462-7. Unique Identifier : AIDSLINE MED/97034108; Rademacher SE; Radolf JD; Department of Internal Medicine, University of Texas Southwestern; Medical Center at Dallas 75235-9113, USA.; Numerous case reports of atypical and/or severe forms of syphilis in individuals coinfected with human immunodeficiency virus (HIV) have led many authorities to conclude that HIV exacerbates early syphilitic infection. Herein we report prominent osseous and unusual dermatologic manifestations of early syphilis in