The proto-oncogene c-myb is expressed in sporadic bovine lymphoma, but not in enzootic bovine leukosis. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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The proto-oncogene c-myb is expressed in sporadic bovine lymphoma, but not in enzootic bovine leukosis.

J Vet Med Sci. 1996 Dec;58(12):1169-74. Unique Identifier : AIDSLINE MED/97149904
Asahina M; Ishiguro N; Wu D; Goryo M; Davis WC; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Japan.

Abstract: We examined bovine c-myb gene expression in six samples of sporadic bovine lymphomas (two calf, three thymic and one intermediate) and five of enzootic bovine leukosis. Tumor cells of the sporadic bovine lymphomas were of immature cell lineage one B lymphoma and five T lymphomas). The c-myb mRNA was expressed in almost all the sporadic bovine lymphomas (except for one thymic form) including a BoCD8 single positive T lymphoma. On the contrary, c-myb was not expressed in mature B lymphomas of enzootic bovine leukosis. The results suggest that c-myb expression is closely associated with tumor cell differentiation of bovine lymphomas.
Keywords: *Enzootic Bovine Leukosis/GENETICS *Leukemia Virus, Bovine/ISOLATION & PURIF *Lymphoma, B-Cell/VETERINARY *Lymphoma, T-Cell/VETERINARY *Proto-Oncogene Proteins/BIOSYNTHESIS *Proto-Oncogenes *Trans-Activators/BIOSYNTHESISKWDenzooticbovineleukosis/geneticsKWDleukemiavirus,bovine/isolation&purifKWDlymphoma,b-cell/veterinaryKWDlymphoma,t-cell/veterinaryKWDproto-oncogeneproteins/biosynthesisKWDproto-oncogenesKWDtrans-activators/biosynthesis
970630
M9761230

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