Absence of human T-lymphotropic virus type I in Japanese patients with cutaneous T-cell lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Absence of human T-lymphotropic virus type I in Japanese patients with cutaneous T-cell lymphoma.

Blood. 1997 Mar 1;89(5):1529-32. Unique Identifier : AIDSLINE MED/97210560
Kikuchi A; Nishikawa T; Ikeda Y; Yamaguchi K; Department of Dermatology, Keio University School of Medicine, Tokyo,; Japan.

Abstract: Cutaneous T-cell lymphoma (CTCL) is a disease entity characterized by a primary sporadic T-cell proliferation in the skin. Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma. Recently, several authors have detected the HTLV-1 genome in genomic DNA from patients with CTCL and proposed a causal relation of HTLV-1 to CTCL. However, it remains controversial because these studies contain some problems in materials used to detect HTLV-1. We investigated both fresh and cultured T lymphocytes (128 specimens) derived from 50 Japanese patients with CTCL, where HTLV-1 is endemic, by using polymerase chain reaction with four sets of primers including gag, pol, env, and pX regions of HTLV-1 to elucidate the relationship between HTLV-1 and CTCL in Japan. However, none of the 128 DNA specimens revealed positive for HTLV-1 in contrast to the previous studies. We conclude that CTCL, which does not include HTLV-1, is present although the pathogenesis of CTCL may be different by areas or races.
Keywords: *HTLV-I/ISOLATION & PURIF *Lymphoma, T-Cell, Cutaneous/VIROLOGY *Skin Neoplasms/VIROLOGYKWDhtlv-i/isolation&purifKWDlymphoma,t-cell,cutaneous/virologyKWDskinneoplasms/virology
970630
M9761223

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