High-performance chromatographic assay for the sulphoxide metabolite of 2'-deoxy-3'-thiacytidine in human urine. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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High-performance chromatographic assay for the sulphoxide metabolite of 2'-deoxy-3'-thiacytidine in human urine.

J Chromatogr B Biomed Appl. 1996 Dec 13;687(2):457-61. Unique Identifier : AIDSLINE MED/97169929
Plumb RS; Gray RD; Harker AJ; Taylor S; Bioanalysis and Drug Metabolism Department, GlaxoWellcome Research and; Develpment, Greenford, Middleses, UK.

Abstract: A high-performance liquid chromatographic method is described for the determination in human urine of GI138870X, the sulphoxide metabolite of a novel dideoxynucleoside analogue, 2'-deoxy-3'-thiacytidine (lamivudine). GI138870X was extracted from human urine using Empore SDB RPS solid-phase extraction disks prior to reversed-phase chromatography with UV detection. The method has shown to be valid over the concentration range 0.5-100 micrograms/ml using a 0.5-ml sample volume.
Keywords: *Anti-HIV Agents/URINE *Chromatography, High Pressure Liquid/METHODS *Cyclic S-Oxides/URINE *Lamivudine/ANALOGS & DERIVATIVESKWDanti-hivagents/urineKWDchromatography,highpressureliquid/methodsKWDcyclics-oxides/urineKWDlamivudine/analogs&derivatives
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M9761205

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