Destroying retroviruses from within. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Destroying retroviruses from within.

Trends Microbiol. 1996 Nov;4(11):421-6. Unique Identifier : AIDSLINE MED/97108164
Boeke JD; Hahn B; Dept of Molecular Biology & Genetics, Johns Hopkins University School; of Medicine, Baltimore, MD 21205, USA. jef.boeke@qmail.bs.jhu.edu

Abstract: One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be efficiently delivered to, and expressed in, appropriate target cells.
Keywords: *Antiviral Agents/THERAPEUTIC USE *Gene Therapy/METHODS *Recombinant Fusion Proteins/THERAPEUTIC USE *Retroviridae Infections/PREVENTION & CONTROLKWDantiviralagents/therapeuticuseKWDgenetherapy/methodsKWDrecombinantfusionproteins/therapeuticuseKWDretroviridaeinfections/prevention&control
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Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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