1997

HHV-8 is associated with recurrent Kaposi's sarcoma in a renal transplant recipient [letter]: Transpl Int. 1997;10(1):81-2. Unique Identifier : AIDSLINE MED/97155459; Noel JC; De Thier F; Heenen M; Fayt I; Abramowicz D; Doutrelepont JM
In vitro and in vivo tumor growth suppression by HIV-1 Vpr.: DNA Cell Biol. 1997 Feb;16(2):137-43. Unique Identifier : AIDSLINE MED/97205230; Mahalingam S; MacDonald B; Ugen KE; Ayyavoo V; Agadjanyan MG; Williams WV; Weiner DB; Department of Medical Microbiology and Immunology, University of South; Florida College of Medicine, Tampa 33612, USA.; We have previously reported that the human immunodeficiency virus type 1 (HIV-1) regulatory gene vpr induces differentiation of rhabdomyosarcoma (embryonal muscle tumor cell line) cells, an effect that is accompanied by reduced proliferative capacity of the transfected cells. In this report, we examine the effect of V
Role of viral infections in the induction of adverse drug reactions.: Drug Saf. 1997 Jan;16(1):1-8. Unique Identifier : AIDSLINE MED/97163885; Levy M; Department of Medicine, Hadassah University Hospital, Ein Karem,; Jerusalem, Israel.; A spectrum of adverse drug reactions that are caused by the combined action of drugs and viruses has been described: ampicillin rash in acute infectious mononucleosis; Reye s syndrome; hypersensitivity reactions to sulphonamides in patients with HIV infection; drug-induced agranulocytosis; paracetamol acetaminophen) h
Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma).: Curr Opin Immunol. 1997 Feb;9(1):17-23. Unique Identifier : AIDSLINE MED/97192250; Trinchieri G; The Wistar Institute of Anatomy and Biology, 3601 Spruce Street,; Philadelphia, PA 19104, USA. trinchieri@wista.wistar.upenn.edu; The three cytokines IL-12, IL-10, and IFN-gamma have important and cross-regulatory roles in infection. In the past year, much progress has been made in the understanding of the cellular and molecular mechanisms involved in the regulation (and cross-regulation) of these three cytokines and their role in pathology. IL-
Changing care: evidence-based decisions in HIV and cytomegalovirus therapy. Proceedings of a satellite symposium to the XI International Conference on AIDS. Vancouver, Canada, 7 July 1996.: AIDS. 1996 Nov;10 Suppl 1:S1-49. Unique Identifier : AIDSLINE MED/97227880
Rational approaches to resistance: using saquinavir.: AIDS. 1996 Nov;10 Suppl 1:S15-9. Unique Identifier : AIDSLINE MED/97125599; Boucher C; Department of Virology, Eykman-Winkler Institute, University Hospital; Utrecht, The Netherlands.; AIM: To review drug-resistance patterns of HIV protease inhibitors , with particular reference to saquinavir, and how resistance and cross-resistance patterns may influence disease management. RESISTANCE TO SAQUINAVIR: Resistance to saquinavir in vitro and in vivo is
Risks and synergies from drug interactions.: AIDS. 1996 Nov;10 Suppl 1:S21-5. Unique Identifier : AIDSLINE MED/97125600; Sahai J; Clinical Investigation Unit, Ottawa General Hospital, Ontario, Canada.; AIM: To review what is known from in vitro and in vivo studies about the interactions, both potentially beneficial and potentially harmful, of antiretroviral agents with each other and with other classes of drugs. INTERACTIONS WITH NUCLEOSIDE ANALOGUES: Some interactions between nucleoside HIV reverse transcriptase in
Changing therapy in HIV.: AIDS. 1996 Nov;10 Suppl 1:S27-30. Unique Identifier : AIDSLINE MED/97125601; Lange JM; NATEC, Academic Medical Centre, University of Amsterdam, The; Netherlands.; AIM: To review recent developments in research into HIV and antiretroviral therapy and how these developments have affected the monitoring and treatment of HIV infection. DEVELOPMENTS AND THEIR IMPLICATIONS: More antiretroviral agents of different types have become available over recent years;
What we know so far.: AIDS. 1996 Nov;10 Suppl 1:S3-7. Unique Identifier : AIDSLINE MED/97125597; Gazzard B; Chelsea and Westminster Hospital, London, UK.; AIM: To review current knowledge of anti-HIV therapy and the implications for patient management. WHAT IS KNOWN: In three large clinical studies, combination therapy with zidovudine plus didanosine or zalcitabine improved survival and delayed clinical events in compari
Lessons learned from HIV pathogenesis and therapy: implications for better management of cytomegalovirus disease.: AIDS. 1996 Nov;10 Suppl 1:S31-5. Unique Identifier : AIDSLINE MED/97125602; Hardy WD; Center for Clinical AIDS Research and Education, UCLA School of; Medicine, USA.; AIM: To review how developments in virological quantitation technology have altered our understanding of the pathogenesis of HIV infection, and the way in which we treat the disease, and to consider how we may apply this type of knowledge to improve the management of cytomegalovirus
Lessons from the natural history of cytomegalovirus.: AIDS. 1996 Nov;10 Suppl 1:S37-41. Unique Identifier : AIDSLINE MED/97125603; Bowen EF; Griffiths PD; Davey CC; Emery VC; Johnson MA; Department of Virology, Royal Free Hospital, London, UK.; BACKGROUND: More than 90% of patients with HIV have been infected at some time with cytomegalovirus ( CMV ) and up to 40% of those with advanced HIV will develop CMV disease. The incidence of CMV disease is increasing but the p
Consequences for the management of cytomegalovirus.: AIDS. 1996 Nov;10 Suppl 1:S43-6. Unique Identifier : AIDSLINE MED/97125604; Katlama C; Groupe Hospitalier Pitie-Salpetriere, Paris, France.; BACKGROUND: Recent advances in the field of antiretroviral therapy have led to a new era where it is possible to effectively prolong the survival of HIV-infected patients. However, a corollary is the increasing prevalence of opportunistic infections, such as cytomegalovirus (
Rational approaches to resistance: nucleoside analogues.: AIDS. 1996 Nov;10 Suppl 1:S9-13. Unique Identifier : AIDSLINE MED/97125598; Mayers D; Walter Reed Army Institute of Research, Rockville, Maryland, USA.; AIM: To review knowledge of drug-resistance patterns to nucleoside HIV reverse transcriptase inhibitors and how this can be used to advantage in patient management. PATTERNS OF RESISTANCE: The speed of emergence of HIV-1 drug resistance is dependent on host, viral and drug factors. Resistance to zidovudine develops ov
Update on the issues of HIV vaccine development.: Ann Med. 1996 Feb;28(1):39-41. Unique Identifier : AIDSLINE MED/97086310; Haynes BF; Putman SB; Weinberg JB; Duke University Arthritis Center, Duke University School of Medicine,; Durham, NC 27710, USA.; Major scientific obstacles blocking the development of a successful preventive HIV vaccine are the extraordinary variability of HIV, the lack of an exact animal model of HIV-induced AIDS, and the lack of understanding of the correlates of positive immunity to HIV. Current HIV vaccines containing the HIV gp120 envelope
Quantification of HIV-1 using multiple competitors in a single-tube assay.: Biotechniques. 1996 Aug;21(2):248-52, 253-5. Unique Identifier : AIDSLINE MED/97016172; Vener T; Axelsson M; Albert J; Uhlen M; Lundeberg J; KTH, Royal Institute of Technology, Swedish Institute for Infectious; Disease Control, Stockholm, Sweden.; Methods for quantification of human immunodeficiency virus type 1 HIV-1) based on competitive PCR and fragment analysis have been developed. Samples containing HIV-1 DNA and known amounts of three cloned competitors were co-amplified by PCR with semi-nested primers. The competitor DNAs contained the same long terminal
Use of flow cytometry and RT-PCR for detecting gene expression by single cells.: Biotechniques. 1996 Aug;21(2):286-91. Unique Identifier : AIDSLINE MED/97016177; Gaynor EM; Mirsky ML; Lewin HA; University of Illinois at Urbana-Champaign, USA.; We have developed a method for reliably detecting gene expression by individual, phenotypically defined cells. Cells were sorted by flow cytometry into 96-well plates containing a Nonidet P-40 NP40)-based bysis solution. Reverse transcription (RT) of cellular major histocompatibility complex class II DQB and either bo
Direct amplification and cloning of up to 5-kb lentivirus genomes from serum.: Biotechniques. 1996 Aug;21(2):312-9. Unique Identifier : AIDSLINE MED/97016181; Holterman L; Mullins JI; Haaijman JJ; Heeney JL; Biomedical Primate Research Centre, Rijswijk, The Netherlands.; To produce large cDNA strands from biological samples containing limited numbers of template molecules, it may be necessary to minimize both nonspecific primer attachment in first-strand synthesis and secondary structure in RNA molecules. Failure to do so could result in the accumulation of shortened cDNA strands and
Regulator and effector functions of T-cell subsets in human Leishmania infections.: APMIS Suppl. 1997;68:1-33. Unique Identifier : AIDSLINE MED/97217472; Kemp M; Centre for Medical Parasitology, University of Copenhagen.; Because of an increasing number of patients suffering from Leishmania infections and because of the serious consequences of these infections more thorough knowledge of the host factors responsible for resistance and susceptibility to the diseases is needed. In murine models of Leishmania infections the cytokine produc
Sonographic measurement of thymic size in healthy neonates. Relation to clinical variables.: Acta Radiol. 1997 Jan;38(1):95-8. Unique Identifier : AIDSLINE MED/97212553; Hasselbalch H; Jeppesen DL; Ersboll AK; Lisse IM; Nielsen MB; Department of Radiology, Hvidovre Hospital, Copenhagen, Denmark.; PURPOSE: To assess the variation in thymic size in healthy neonates by sonography and to study the possible correlation to clinical variables. MATERIAL AND METHODS: A study was made of 149 healthy term infants, at less than one week of age. The size of the thymus was assessed by sonography as a volume estimate, the th
The transition from underground to legal syringe exchange: the New York City experience.: AIDS Educ Prev. 1996 Dec;8(6):471-89. Unique Identifier : AIDSLINE MED/97163701; Kochems LM; Paone D; Des Jarlais DC; Ness I; Clark J; Friedman SR; Chemical Dependency Institute, Beth Israel Medical Center, New York,; NY 10003, USA.; The most common method of syringe exchange program (SEP) development in the United States has been for SEPs to be started by activists without funding and then to become a government-funded community-based organization. This developmental process, which has not been studied to date, in
Multiple sexual partners and condom use among long-distance truck drivers in Thailand.: AIDS Educ Prev. 1996 Dec;8(6):490-8. Unique Identifier : AIDSLINE MED/97163702; Podhisita C; Wawer MJ; Pramualratana A; Kanungsukkasem U; McNamara R; Institute for Population and Social Research, Mahidol University,; Bangkok, Thailand.; Sexual behaviors of long-distance truck drivers in Thailand were investigated to define patterns and determinants critical to the transmission of HIV. This article reports on commercial, spousal, and other sexual partners and on condom use among 327 drivers interviewed in 1992. F
Predictors of African American adolescents' condom use and HIV risk behavior.: AIDS Educ Prev. 1996 Dec;8(6):499-515. Unique Identifier : AIDSLINE MED/97163703; Reitman D; St. Lawrence JS; Jefferson KW; Alleyne E; Brasfield TL; Shirley A; Jackson State University, MS 39217-0105, USA.; This study evaluated predictors of risky and safer behavior in a sample of low-income African American adolescents, assessed their perceptions of the risk associated with their sexual behavior, and examined differences between adolescents who used condoms consistently, inconsistently, or engaged only in unprotected in
Effects of an institutional AIDS prevention intervention: moderation by gender.: AIDS Educ Prev. 1996 Dec;8(6):516-28. Unique Identifier : AIDSLINE MED/97163704; O'Leary A; Jemmott LS; Goodhart F; Gebelt J; Department of Psychology, Rutgers University, New Brunswick, NJ 08903,; USA.; AIDS risk reduction programs are being conducted in many institutional settings, but rigorous evaluations of their effectiveness are lacking. This is particularly unfortunate in that these programs are expensive, and tend to be of lower intensity than those that have been shown to be effective. Further, risk reduction
HIV seropositive gay men: understanding adoption of safe sexual practices.: AIDS Educ Prev. 1996 Dec;8(6):529-45. Unique Identifier : AIDSLINE MED/97163705; Godin G; Savard J; Kok G; Fortin C; Boyer R; L'Ecole des sciences infirmieres, Universite Laval, Ste-Foy, Quebec,; Canada.; The aim of this study was to determine the best predictors of safe sex practices among HIV seropositive gay men. A group of 96 homosexual men living with HIV completed a questionnaire that investigated theoretical constructs of the Ajzen s (1988) theory of planned behavior with respect to condom use for anal intercour
Differences between gay men in primary relationships and single men: implications for prevention.: AIDS Educ Prev. 1996 Dec;8(6):546-59. Unique Identifier : AIDSLINE MED/97163706; Hoff CC; Coates TJ; Barrett DC; Collette L; Ekstrand M; Department of Medicine, University of California, San Francisco, USA.; This study describes psychological and behavioral differences between gay men in primary relationships and single men from 1985 through 1989. In addition, differences in sexual behavior, relationship status, and relationship quality between HIV positive and HIV negative men were investigated. Data are from the San Fra
Therapeutic effects of glycyrrhizin in mice infected with LP-BM5 murine retrovirus and mechanisms involved in the prevention of disease progression.: Biotherapy. 1996;9(4):209-20. Unique Identifier : AIDSLINE MED/97164758; Watanbe H; Miyaji C; Makino M; Abo T; Department of Immunology, Niigata University School of Medicine,; Japan.; Glycyrrhizin (GL), a plant extract, has been evaluated for its inhibitory effect on HIV replication in vitro and for its improvement of clinical symptoms in HIV-infected patients. In this study, we used GL in a murine AIDS model (MAIDS) to evaluate these effects. C57BL/6 mice were inoculated with LP-BM5 murine leukemi
Human immunodeficiency virus risk behavior among white and Asian/Pacific Islander high school students in the United States: does culture make a difference?: J Adolesc Health. 1997 Jan;20(1):68-74. Unique Identifier : AIDSLINE MED/97160146; Hou SI; Basen-Engquist K; School of Public Health, University of Texas, Health Science Center at; Houston, USA.; PURPOSE: This article analyzes sexual behavior among white and Asian/Pacific Islander (API) adolescents, to determine the risk for human immunodeficiency virus (HIV) transmission from a multicultural point of view. METHODS: A total of 5,385 white and 408 API high school students were included. The national school-base
The proto-oncogene c-myb is expressed in sporadic bovine lymphoma, but not in enzootic bovine leukosis.: J Vet Med Sci. 1996 Dec;58(12):1169-74. Unique Identifier : AIDSLINE MED/97149904; Asahina M; Ishiguro N; Wu D; Goryo M; Davis WC; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Japan.; We examined bovine c-myb gene expression in six samples of sporadic bovine lymphomas (two calf, three thymic and one intermediate) and five of enzootic bovine leukosis. Tumor cells of the sporadic bovine lymphomas were of immature cell lineage one B lymphoma and five T lymphomas). The c-myb mRNA was expressed in almos
Ordered aggregation of ribonucleic acids by the human immunodeficiency virus type 1 nucleocapsid protein.: Biopolymers. 1997 Mar;41(3):301-12. Unique Identifier : AIDSLINE MED/97210422; Stoylov SP; Vuilleumier C; Stoylova E; De Rocquigny H; Roques BP; Gerard D; Mely Y; Laboratoire de Biophysique, URA 491 du CNRS, Faculte de Pharmacie de; Strasbourg I, Illkirch, France.; The nucleocapsid protein NCp7, which is the major genomic RNA binding protein of human immunodeficiency virus type 1, plays an important role in several key steps of the viral life cycle. Many of the NCp7 activities, notably the nucleic acid annealing and the genomic RNA wrapping ones, are thought to be linked to a no
Characterization of anti-tumor immunity derived from the inoculation of myeloma cells secreting the fusion protein RM4/IFN-tau.: Hum Antibodies Hybridomas. 1996;7(1):21-6. Unique Identifier : AIDSLINE MED/97041562; Qi Y; Moyana T; Chen Y; Xiang J; Saskatoon Cancer Center, College of Medicine, University of; Saskatchewan, Canada.; Our previous study showed that the injection of mouse myeloma VKCK/RM4-IFN-tau cells secreting the fusion protein RM4/IFN-tau to syngeneic BALB/c mice resulted in tumor regression in 70% of mice after tumor inoculation. In this study, the VKCK/RM4-IFN-tau cell line was used to characterize the protective immunity subs
Curative effect of split low dosage total-body irradiation on murine AIDS induced by Friend virus: the results and the possible mechanism.: In Vivo. 1996 Mar-Apr;10(2):191-9. Unique Identifier : AIDSLINE MED/96348850; Shen RN; Lu L; Kaiser HE; Broxmeyer HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202-5121, USA.; Mice infected with Friend Leukemia Virus (FLV) rapidly develop erythroleukemia and severe immune deficiency which resembles human AIDS. We have reported that mice infected with a lethal dose of FLV can be 100% cured by 150 cGy total body irradiation TBI). This curative effect was associated with restoration of cellula
Naturin: a potent bio-immunomodifier in experimental studies and clinical trials.: In Vivo. 1996 Mar-Apr;10(2):201-9. Unique Identifier : AIDSLINE MED/96348851; Shen RN; Lu L; Jia XQ; Wong ML; Kaiser HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 16202-5121, USA.; A number of traditional Chinese medicinal herbs have become extremely interesting in the search for potential BRMs in the international medical community, especially in the United States and Japan . Naturin, a new Chinese medical herb produced by Xing
Meningocerebral lesions in children with iatrogenic AIDS.: Rom J Morphol Embryol. 1996 Jan-Jun;42(1-2):53-62. Unique Identifier : AIDSLINE MED/97190403; Bogdan FL; Radu I; Mogoanta L; Frasie M; Department of Histology, Faculty of Medicine, Craiova, Romania.; This study is focused on structural modifications of leptomeninges and cerebral matter in children deceased because of iatrogenic AIDS. Although we do not evidence the specific lesions of AIDS, we have noticed edema, hyperemia, hematic extravasation, microlesions of the small vessel walls, perivascular infiltrations w
Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta.: Blood. 1997 Mar 1;89(5):1491-500. Unique Identifier : AIDSLINE MED/97210555; Cai J; Zheng T; Lotz M; Zhang Y; Masood R; Gill P; Department of Internal Medicine, University of Southern California; School of Medicine, Los Angeles, USA.; Glucocorticoid (GC) use is known to induce or enhance the growth of Kaposi s sarcoma (KS) in many clinical settings including human immunodeficiency virus infection, collagen vascular disease, lymphoproliferative disorders, and renal transplantation. Because GCs may induce immune suppression and thus tumor growth, we
Absence of human T-lymphotropic virus type I in Japanese patients with cutaneous T-cell lymphoma.: Blood. 1997 Mar 1;89(5):1529-32. Unique Identifier : AIDSLINE MED/97210560; Kikuchi A; Nishikawa T; Ikeda Y; Yamaguchi K; Department of Dermatology, Keio University School of Medicine, Tokyo,; Japan.; Cutaneous T-cell lymphoma (CTCL) is a disease entity characterized by a primary sporadic T-cell proliferation in the skin. Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma. Recently, several authors have detected the HTLV-1 genome in genomic DNA from patients with C
Loss of inducible virus in CD45RA naive cells after human immunodeficiency virus-1 entry accounts for preferential viral replication in CD45RO memory cells.: Blood. 1997 Mar 1;89(5):1635-41. Unique Identifier : AIDSLINE MED/97210573; Woods TC; Roberts BD; Butera ST; Folks TM; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; Controversy exists concerning the preferential infection and replication of human immunodeficiency virus-1 (HIV-1) within naive (CD45RA+) and memory (CD45RO+) subsets of CD4+ lymphocytes. To explore the susceptibility of these subsets to HIV-1 infection, we purified CD45RA+/CD4+ (RA) and CD45RO+/CD4+ (RO) cells from n
Upregulation of c-Fos in activated T lymphoid and monocytic cells by human immunodeficiency virus-1 Tat protein.: Blood. 1997 Mar 1;89(5):1654-64. Unique Identifier : AIDSLINE MED/97210575; Gibellini D; Caputo A; Capitani S; La Placa M; Zauli G; Institute of Microbiology, University of Bologna, Italy.; The regulatory Tat protein of the human immunodeficiency virus type-1 (HIV-1) is essential for viral replication and also shows pleiotropic activities on various cell functions. To get further insights into the molecular mechanisms underlying the biological activity of Tat, we investigated the effect of endogenous and
Is Kaposi's sarcoma--associated herpesvirus ubiquitous in urogenital and prostate tissues?: Blood. 1997 Mar 1;89(5):1686-9. Unique Identifier : AIDSLINE MED/97210578; Tasaka T; Said JW; Morosetti R; Park D; Verbeek W; Nagai M; Takahara J; Koeffler HP; Department of Medicine and Pathology, Cedars-Sinai Medical Center,; UCLA School of Medicine, USA.; Controversy exists as to whether Kaposi s sarcoma-associated herpesvirus (KSHV) is more widespread than originally reported. Recently, Monini et al reported that KSHV is ubiquitous in urogenital and prostate tissues and sperm of healthy Italian adults using nested polymerase chain reaction (PCR). We have examined for
Epstein-Barr virus strains with latent membrane protein-1 deletions: prevalence in the Italian population and high association with human immunodeficiency virus-related Hodgkin's disease.: Blood. 1997 Mar 1;89(5):1723-31. Unique Identifier : AIDSLINE MED/97210583; Dolcetti R; Zancai P; De Re V; Gloghini A; Bigoni B; Pivetta B; De Vita S; Carbone A; Boiocchi M; Division of Experimental Oncology 1, Centro di Riferimento Oncologico,; Aviano, Italy.; Six Epstein-Barr virus (EBV)-related lymphoproliferative disorders were investigated to verify whether the EBV strain harbored by neoplastic cells had the same EBNA-2 and latent membrane protein-1 (LMP-1) DNA sequences of the virus carried by normal lymphocytes of the same patients. Within each case, the analysis of n
Lack of evidence of HHV-8 DNA in blood cells from heart transplant recipients [letter]: Blood. 1997 Mar 1;89(5):1837-8. Unique Identifier : AIDSLINE MED/97210600; De Milito A; Venturi G; Catucci M; Romano L; Bianchi Bandinelli ML; Zazzi M
Efficient in vivo marking of primary CD4+ T lymphocytes in nonhuman primates using a gibbon ape leukemia virus-derived retroviral vector.: Blood. 1997 Mar 15;89(6):1987-95. Unique Identifier : AIDSLINE MED/97211753; Bunnell BA; Metzger M; Byrne E; Morgan RA; Donahue RE; Clinical Gene Therapy Branch, National Center for Human Genome; Research, Bethesda, MD 20850, USA.; High efficiency retroviral-mediated gene transfer to rhesus CD4+ peripheral blood lymphocytes (PBL) was accomplished using an optimized transduction protocol using a gibbon ape leukemia virus GaLV) envelope-containing packaging cell line PG13. Engineered CD4+ PBL were administered to three nonmyeloablated animals in t
Differences between graft-versus-leukemia and graft-versus-host reactivity. I. Interaction of donor immune T cells with tumor and/or host cells.: Blood. 1997 Mar 15;89(6):2189-202. Unique Identifier : AIDSLINE MED/97211777; Rocha M; Umansky V; Lee KH; Hacker HJ; Benner A; Schirrmacher V; Deutsches Krebsforschungszentrum Heidelberg, Abteilung Zellulare; Immunologie, FSP Tumorimmunologie, Germany.; Graft-versus-leukemia (GVL) and Graft-versus-host (GVH) reactions were compared after systemic transfer of allogeneic antitumor immune T lymphocytes from B10.D2 (H-2d; Mls(b)) into DBA/2 (H-2d; Mis(a)) mice. Before immune cell transfer, recipient DBA/2 mice were sublethally irradiated with 5 Gy to prevent host-versus-
Intragraft IL-4 mRNA expression is associated with down-regulation of liver graft rejection.: Clin Transplant. 1996 Dec;10(6 Pt 1):542-9. Unique Identifier : AIDSLINE MED/97150003; Baan CC; Metselaar HJ; Mol WM; Tilanus HW; IJermans JM; Zondervan PE; Schalm SW; Niesters HG; Weimar W; Department of Internal Medicine, University Hospital; Rotterdam-Dijkzigt, The Netherlands.; The mechanism underlying spontaneously resolving allograft rejection following clinical liver transplantation is unidentified. In this process, immunoregulatory T helper (Th)-2 cytokines like IL-4, often identified with down-regulation of the Th1-dependent ( IL-2 ) cell-
Clinical presentation of pulmonary tuberculosis associated with acquired immunodeficiency syndrome in metropolitan Tokyo.: Intern Med. 1996 Dec;35(12):946-52. Unique Identifier : AIDSLINE MED/97182853; Kanazawa M; Fujita A; Toyoda T; Takasugi T; Osumi M; Nishio K; Suzuki A; Ogata H; Iwai K; Department of Medicine, School of Medicine, Keio University, Tokyo.; The clinical features of pulmonary tuberculosis associated with acquired immunodeficiency syndrome (AIDS) in Japan were surveyed utilizing questionnaires completed by 48 institutes around the Tokyo metropolitan area. We found 11 Japanese and six foreign patients. The average number
Using the Kalman filter and dynamic models to assess the changing HIV/AIDS epidemic.: Math Biosci. 1997 Mar;140(2):131-54. Unique Identifier : AIDSLINE MED/97198756; Cazelles B; Chau NP; Centre de Bioinformatique, Universite Paris, France.; Many factors, including therapy and behavioral changes, have modified the course of the HIV/AIDS epidemic in recent years. To include these modifications in HIV/AIDS models, in the absence of appropriate external data sources, changes over time in the parameters can be incorporated by a recursive estimation technique
[Experiences of the "sexually transmitted disease counseling service" of the Recklinghausen district public health office]: Gesundheitswesen. 1996 Dec;58(12):699-702. Unique Identifier : AIDSLINE MED/97177843; Ruter O; Arztin des Gesundheitsamtes, Kreisgesundheitsamt Recklinghausen, Marl.
The effect of adding a surfeit of autologous CD8+ T cells to SCID mice after secondary rexenografts of Graves' thyroid tissue.: Thyroid. 1996 Oct;6(5):429-36. Unique Identifier : AIDSLINE MED/97090780; Mukuta T; Nishikawa M; Arreaza G; Resetkova E; Yoshikawa N; Fornasier V; Young E; Volpe R; Endocrinology Research Laboratory, Wellesley Hospital, University of; Toronto, Ontario, Canada.; To investigate the effect of adding a surfeit of CD8+ T cells as a potential immunoregulator in Graves disease (GD), thyroid tissues from 4 patients with GD and 2 normal subjects (N) were initially xenografted into nude mice. Eight weeks after xenografting, the thyroid tissues, which were then devoid of lymphocytes a
The murine (H-2k) T-cell epitopes of bee venom phospholipase A2 Lie outside the active site of the enzyme. Implications with respect to a paracrine activation of Th2 cells for an IgE antibody response.: Int Arch Allergy Immunol. 1997 Mar;112(3):226-30. Unique Identifier : AIDSLINE MED/97219207; Specht C; Kolsch E; Institute for Immunology, University of Munster, Germany.; Recombinant, enzymatic active phospholipase A2 from bee venom PLA2) is a potent inducer of IgE antibody formation in CBA/J H-2k) mice. In contrast, a recombinant mutant protein lacking enzymatic activity due to an amino acid exchange in the active site of the enzyme fails to induce IgE antibodies under identical immun
Survival after diagnosis of AIDS: a prospective observational study of 2625 patients. Royal Free/Chelsea and Westminster Hospitals Collaborative Group.: BMJ. 1997 Feb 8;314(7078):409-13. Unique Identifier : AIDSLINE MED/97192794; Mocroft A; Youle M; Morcinek J; Sabin CA; Gazzard B; Johnson MA; Phillips AN; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London.; OBJECTIVE: To estimate median survival and changes in survival in patients diagnosed as having AIDS. DESIGN: Prospective observational study. SETTING: Clinics in two large London hospitals. SUBJECTS: 2625 patients with AIDS seen between 1982 and July 1995. MAIN OUTCOME MEASURES: Survival, estimated using lifetable ana
Recent advances. HIV infection--I.: BMJ. 1997 Feb 15;314(7079):487-91. Unique Identifier : AIDSLINE MED/97209626; Cohn JA; School of Medicine, Wayne State University, Detroit, MI 48201-2907,; USA. JCohn@oncgate.roc.wayne.edu
Recent advances. HIV infection-II.: BMJ. 1997 Feb 22;314(7080):579-83. Unique Identifier : AIDSLINE MED/97208778; Beiser C; Institute of Human Virology, University of Maryland Medical System,; Baltimore, USA.
Those who believe in alternative theories of AIDS have little room for manoeuvre [letter]: BMJ. 1997 Feb 22;314(7080):607-8. Unique Identifier : AIDSLINE MED/97208806; Derbyshire SW
High-performance chromatographic assay for the sulphoxide metabolite of 2'-deoxy-3'-thiacytidine in human urine.: J Chromatogr B Biomed Appl. 1996 Dec 13;687(2):457-61. Unique Identifier : AIDSLINE MED/97169929; Plumb RS; Gray RD; Harker AJ; Taylor S; Bioanalysis and Drug Metabolism Department, GlaxoWellcome Research and; Develpment, Greenford, Middleses, UK.; A high-performance liquid chromatographic method is described for the determination in human urine of GI138870X, the sulphoxide metabolite of a novel dideoxynucleoside analogue, 2 -deoxy-3 -thiacytidine (lamivudine). GI138870X was extracted from human urine using Empore SDB RPS solid-phase extraction disks prior to re
The role of cholecystectomy in acquired immunodeficiency syndrome [see comments]: J Am Coll Surg. 1997 Mar;184(3):233-9. Unique Identifier : AIDSLINE MED/97214537; Flum DR; Steinberg SD; Sarkis AY; Pacholka JR; Wallack MK; Department of Surgery, St. Vincent's Hospital and Medical Center, New; York, NY, USA.; BACKGROUND: Hepatobiliary disease is a common manifestation of acquired immunodeficiency syndrome, although the role of surgical intervention in the spectrum of therapy is unclear. STUDY DESIGN: A retrospective review was designed to evaluate the characteristics of patients given a diagnosis of human immunodeficiency
The role of cholecystectomy in acquired immunodeficiency syndrome [editorial; comment] [see comments]: J Am Coll Surg. 1997 Mar;184(3):309-10. Unique Identifier : AIDSLINE MED/97214550; Soper NJ
Indirect muscarinic receptor activation by pentamidine on airway smooth muscle.: Br J Pharmacol. 1996 Nov;119(6):1131-6. Unique Identifier : AIDSLINE MED/97092050; Biyah K; Molimard M; Naline E; Bazelly B; Advenier C; Laboratoire de Pharmacologie, Faculte de Medecine Paris Ouest, France.; 1. Pentamidine is routinely used to reduce the incidence of Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus, but it has been described as inducing pulmonary adverse effects, such as cough and bronchospasm. 2. In this paper we have investigated the effects of pentamidine on guinea-
An atypical case of parasuicide or 'bradysuicide' [letter]: Br J Psychiatry. 1996 Dec;169(6):795-6. Unique Identifier : AIDSLINE MED/97123401; Maniam T
Kaposi's sarcoma and HHV-8 [letter]: Trends Microbiol. 1996 Nov;4(11):419. Unique Identifier : AIDSLINE MED/97108163; Offermann MK
Destroying retroviruses from within.: Trends Microbiol. 1996 Nov;4(11):421-6. Unique Identifier : AIDSLINE MED/97108164; Boeke JD; Hahn B; Dept of Molecular Biology & Genetics, Johns Hopkins University School; of Medicine, Baltimore, MD 21205, USA. jef.boeke@qmail.bs.jhu.edu; One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be
A community P.A.R. Approach to HIV/AIDS prevention among sex workers.: Promot Educ. 1996 Dec;3(4):25-8. Unique Identifier : AIDSLINE MED/97206379; Tiglao TV; Morisky DE; Tempongko SB; Baltazar JC; Detels R; University of the Philippines, College of Public Health, Department of; Health Promotion and Education, Manila, Philippines.
Gut Coccidia-- Isospora, Cryptosporidium, Cyclospora and Sarcocystis.: Semin Gastrointest Dis. 1997 Jan;8(1):33-44. Unique Identifier : AIDSLINE MED/97153210; Ackers JP; Department of Medical Parasitology, London School of Hygiene &; Tropical Medicine, UK.; The gut Coccidia are members of a large, varied, and exclusively intracellular group of protozoan parasites, four species of which Isospora, Cryptosporidium, Cyclospora, and Sarcocystis) are human pathogens. The first three, but particularly Cryptosporidium parvum, have moved from medical curiosities to major problems
Intestinal microsporidiosis.: Semin Gastrointest Dis. 1997 Jan;8(1):45-55. Unique Identifier : AIDSLINE MED/97153211; Croft SL; Williams J; McGowan I; Department of Medical Parasitology, London School of Hygiene and; Tropical Medicine, UK.; Intestinal microsporidiosis is caused by the protozoan parasites Enterocytozoon bieneusi and Encephalitozoon intestinalis. The disease has been described within the past decade and is found predominantly in acquired immunodeficiency syndrome (AIDS) patients in associat
Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques.: Curr Biol. 1996 Nov 1;6(11):1519-27. Unique Identifier : AIDSLINE MED/97147820; Sawai ET; Khan IH; Montbriand PM; Peterlin BM; Cheng-Mayer C; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616, USA. etsawai@ucdavis.edu; BACKGROUND: The primate lentiviruses, human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), encode a conserved accessory gene product, Nef. In vivo, Nef is important for the maintenance of high virus loads and progression to AIDS in SIV-infected adult rhesus macaques. In
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons.: Curr Biol. 1997 Feb 1;7(2):112-21. Unique Identifier : AIDSLINE MED/97227891; Hesselgesser J; Halks-Miller M; DelVecchio V; Peiper SC; Hoxie J; Kolson DL; Taub D; Horuk R; Department of Immunology, Berlex Biosciences, Richmond, California; 94804, USA. Joe_Hesselgesser@berlex.com; BACKGROUND: Chemokines are a family of proteins that chemoattract and activate immune cells by interacting with specific receptors on the surface of their targets. We have shown previously that chemokine receptors including the interleukin-8 receptor B CXCR2) and the Duffy blood group antigen are expressed on subsets
Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion.: Gene Ther. 1996 Jan;3(1):4-12. Unique Identifier : AIDSLINE MED/97083332; DeMatteo RP; Markmann JF; Kozarsky KF; Barker CF; Raper SE; Institute for Human Gene Therapy, University of Pennsylvania Medical; Center, Philadelphia, USA.; Although first generation recombinant adenoviruses are efficient vehicles for gene transfer, their immunogenicity precludes long-term persistence. We show that adenoviral transgene expression in the liver of normal mice is prolonged from a baseline of less than 2 weeks to 7 weeks by depleting CD4+ T lymphocytes with t
High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS.: Gene Ther. 1997 Feb;4(2):128-39. Unique Identifier : AIDSLINE MED/97226862; Plavec I; Agarwal M; Ho KE; Pineda M; Auten J; Baker J; Matsuzaki H; Escaich S; Bonyhadi M; Bohnlein E; Progenesys Program, SyStemix Inc, Palo Alto, CA 94304, USA.; Expression of antiviral genes in CD4+ T cells has been proposed as a strategy for gene therapy of AIDS. Over the past years, we and others have developed retroviral vectors encoding the RevM10 protein, a dominant-negative mutant of the HIV-1 Rev trans-activator protein. We could demonstrate gene transfer and inhibitio
Induction of somatic mutation in a human B cell line in vitro.: Immunity. 1997 Jan;6(1):35-46. Unique Identifier : AIDSLINE MED/97205331; Denepoux S; Razanajaona D; Blanchard D; Meffre G; Capra JD; Banchereau J; Lebecque S; Schering-Plough Laboratory for Immunological Research, Dardilly,; France.; Both the B cell-surface trigger(s) and the intracellular molecular mechanism(s) of somatic hypermutation in immunoglobulin Ig) variable region genes remain unknown, partly because of the lack of a simple and reproducible in vitro model. Here, we show that upon surface immunoglobulin cross-linking followed by co-cultur
The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.: Immunity. 1997 Jan;6(1):67-77. Unique Identifier : AIDSLINE MED/97205334; Mangasarian A; Foti M; Aiken C; Chin D; Carpentier JL; Trono D; Infectious Disease Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; The HIV Nef protein down-regulates the cell surface expression of CD4 and of MHC I at least in part through accelerated endocytosis. To investigate further the mechanism of this effect, we created chimeric integral membrane proteins comprising the extracellular and transmembrane regions of CD4 or CD8 and Nef as the cy
Neonatal injection of an ovarian peptide induces autoimmune ovarian disease in female mice: requirement of endogenous neonatal ovaries.: Immunity. 1997 Jan;6(1):89-96. Unique Identifier : AIDSLINE MED/97205336; Garza KM; Griggs ND; Tung KS; Department of Microbiology, University of Virginia, Charlottesville; 22908, USA.; Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is esta
[Proliferative mechanism and control of AIDS virus]: Nihon Rinsho Meneki Gakkai Kaishi. 1996 Dec;19(6):548-51. Unique Identifier : AIDSLINE MED/97194327; Okamoto H
[Physiopathology and gene therapy of HIV infection]: Nihon Rinsho Meneki Gakkai Kaishi. 1996 Dec;19(6):651-3. Unique Identifier : AIDSLINE MED/97194347; Matsushita S
Central areolar choroidal dystrophy and slowly progressive sensorineural hearing loss.: Acta Ophthalmol Scand. 1996 Dec;74(6):639-41. Unique Identifier : AIDSLINE MED/97169500; Hoyng CB; van Rijn PM; Deutman AF; Department of Ophthalmology, University of Nijmegen, The Netherlands.; Central areolar choroidal dystrophy (CACD) is a rare hereditary disorder leading to a central scotoma in middle-aged patients. Two cases of CACD in association with perceptive hearing loss are discussed. A 62-year-old male and a 51-year-old female patient complained of visual deterioration and subsequent hearing loss
Protamine enhances the activity of human recombinant interferon-gamma.: J Interferon Cytokine Res. 1996 Jul;16(7):531-6. Unique Identifier : AIDSLINE MED/96433940; Daubener W; Gutsche M; Nockemann S; MacKenzie C; Seghrouchni S; Hadding U; Institut fur Medizinische Mikrobiologie und Virologie,; Heinrich-Heine-Universitat Dusseldorf, Germany.; Recombinant interferon-gamma (IFN-gamma) is a potent immune regulatory cytokine and is involved in the defense against several intracellular organisms, such as Chlamydia and Toxoplasma. Furthermore IFN-gamma is able to inhibit the growth of human tumor cell lines. The ability to inhibit the growth of intracellular org
Aetiological factors for oral manifestations of HIV.: Oral Dis. 1996 Sep;2(3):193-7. Unique Identifier : AIDSLINE MED/97227796; Palmer GD; Robinson PG; Challacombe SJ; Birnbaum W; Croser D; Erridge PL; Hodgson T; Lewis D; McLaren A; Zakrzewska JM; United Medical School, Guy's Hospital, London, UK.; OBJECTIVES: Describe the oral diseases in HIV-infected individuals in London, UK and identify social and medical factors related to the presence of specific oral diseases. DESIGN: Dental clinics. SUBJECTS: Consecutive sample of 456 patients with HIV infection. METHODS: Social and medical history and clinical examinati
Oral HIV-I recovery in the presence of periodontal disease.: Oral Dis. 1996 Sep;2(3):198-201. Unique Identifier : AIDSLINE MED/97227797; Barr CE; Qureshi MN; Qiu Z; Kaim J; Zhang W; Department of Dental Medicine, Beth Israel Medical Center, New York; 10003, USA.; OBJECTIVE: To determine whether a significant association occurs between the presence of various periodontal diseases and recoverable infectious HIV-I in the saliva of injecting drug users. DESIGN: Five hundred and fifty-one injecting drug users were recruited from various programs associated with the Beth Israel Medi
HIV-1 infection in an individual homozygous for the CCR5 deletion allele [letter; comment]: Nat Med. 1997 Mar;3(3):252-3. Unique Identifier : AIDSLINE MED/97208900; Biti R; Ffrench R; Young J; Bennetts B; Stewart G; Liang T
HIV-1: gambling on the evolution of drug resistance?: Nat Med. 1997 Mar;3(3):268-71. Unique Identifier : AIDSLINE MED/97208904; Brown AJ; Richman DD; Centre for HIV Research, University of Edinburgh, Scotland.
Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.: Nat Med. 1997 Mar;3(3):287-92. Unique Identifier : AIDSLINE MED/97208913; Nicholas J; Ruvolo VR; Burns WH; Sandford G; Wan X; Ciufo D; Hendrickson SB; Guo HG; Hayward GS; Reitz MS; Department of Oncology, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; Human herpesvirus-8 (HHV-8) has been detected in Kaposi s sarcoma KS) lesions of all types (AIDS-related, classical and endemic), in body-cavity-based B-cell lymphomas (BCBLs) and in lesions of multicentric Castleman s disease (MCD). We have identified a major gamma-herpesvirus-divergent locus (DL-B) in HHV-8 DNA enco
Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue.: Nat Med. 1997 Mar;3(3):293-8. Unique Identifier : AIDSLINE MED/97208914; Sarid R; Sato T; Bohenzky RA; Russo JJ; Chang Y; Department of Pathology, Columbia University College of Physicians &; Surgeons, New York, New York 10032, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) is a newly discovered herpesvirus etiologically associated with Kaposi s sarcoma (KS) and two lymphoproliferative disorders. We describe a KSHV vbcl-2 gene with homology to the proto-oncogene bcl-2. It is expressed in KS lesions and in cell lines derived from primary effu
The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication.: Nat Med. 1997 Mar;3(3):333-7. Unique Identifier : AIDSLINE MED/97208921; Chinnaiyan AM; Woffendin C; Dixit VM; Nabel GJ; Department of Pathology, University of Michigan Medical Center, Ann; Arbor, Michigan 48109-0602, USA.; Accelerated programmed cell death, or apoptosis, contributes to the CD4+ T-cell depletion characteristic of infection by human immunodeficiency virus (HIV). It has therefore been proposed that limiting apoptosis may represent a therapeutic modality for HIV infection. We found, however, that T leukemia cells or periphe
The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression.: Nat Med. 1997 Mar;3(3):338-40. Unique Identifier : AIDSLINE MED/97208922; Michael NL; Chang G; Louie LG; Mascola JR; Dondero D; Birx DL; Sheppard HW; Division of Retrovirology, Walter Reed Army Institute of Research,; Rockville, Maryland, USA.; Cellular entry of human immunodeficiency virus type 1 (HIV-1) requires binding to both CD4 (ref, 1, 2) and to one of the chemokine receptors recently discovered to act as coreceptors. Viruses that infect T-cell lines to form syncytia syncytium-inducing, SI) are frequently found in late-stage HIV disease and utilize th
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.: Nat Med. 1997 Mar;3(3):341-5. Unique Identifier : AIDSLINE MED/97208923; Rice WG; Turpin JA; Huang M; Clanton D; Buckheit RW Jr; Covell DG; Wallqvist A; McDonnell NB; DeGuzman RN; Summers MF; Zalkow L; Bader JP; Haugwitz RD; Sausville EA; Laboratory of Antiviral Drug Mechanisms, National Cancer; Institute-Frederick Cancer Research and Development Center, SAIC; Frederick, Maryland 21702, USA.; Nucleocapsid p7 (NCp7) proteins of human immunodeficiency virus type 1 (HIV-1) contain two zinc binding domains of the sequence Cys-(X)2-Cys-(X)4-His-(X)4-Cys (CCHC). The spacing pattern and metal-chelating residues (3 Cys, 1 His) of these nucleocapside CCHC zinc fingers are highly conserved among retroviruses. These
Secondary immunodeficiencies and stem cell transplantation: issues of administration and safety of intravenous immunoglobulin.: Clin Ther. 1996;18 Suppl B:126-36. Unique Identifier : AIDSLINE MED/97084106; Sullivan KM; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; This article reviews the administration, efficacy, and safety of prophylactic intravenous immunoglobulin in patients with secondary immunodeficiency and those undergoing allogeneic bone marrow transplantation. Associated infections in these immunosuppressed patients are examined as they relate to transfusion-associate
Hepatitis C virus infection in Italian patients with hypogammaglobulinemia.: Clin Ther. 1996;18 Suppl B:96-107. Unique Identifier : AIDSLINE MED/97084103; Quinti I; Pandolfi F; Paganelli R; Giovannetti A; Sacco G; Oliva A; Aiuti F; Department of Allergy and Clinical Immunology, University La Sapienza,; Rome, Italy.; We investigated the presence of hepatitis C virus (HCV) infection in 58 patients with humoral immunodeficiencies. Forty-three of these patients had common variable immunodeficiency (CVI), 2 had sporadic hyperimmunoglobulin M (HIM) syndrome, 2 had immunoglobulin G subclass deficiency, 4 had ataxia-telangiectasia AT), a
Experts attempt to redefine principles for treating HIV [news]: Nat Biotechnol. 1997 Jan;15(1):14-5. Unique Identifier : AIDSLINE MED/97187643; Fox JL
A new class of antigen-specific killer cells [see comments]: Nat Biotechnol. 1997 Jan;15(1):46-51. Unique Identifier : AIDSLINE MED/97187652; Yang AG; Chen SY; Department of Cancer Biology, Bowman Gray School of Medicine, Wake; Forest University, Winston-Salem, NC 27157, USA.; A new class of antigen-specific killer cells that combines the features of antibody-mediated and cell-mediated immunity was designed. The principle and feasibility of this strategy are illustrated by creating an antigen-specific killer cell to produce and secrete targeted antibody-toxin molecules that recognize and ki
The MHC reactivity of the T cell repertoire prior to positive and negative selection.: Cell. 1997 Mar 7;88(5):627-36. Unique Identifier : AIDSLINE MED/97207009; Zerrahn J; Held W; Raulet DH; Department of Molecular and Cell Biology, Cancer Research Laboratory,; University of California, Berkeley 94720, USA.; T cell antigen receptors (TCRs) on mature T cells react with peptide antigens presented by self-MHC proteins and also frequently cross-react with foreign MHC proteins. The fundamental question whether MHC reactivity is inherent in the germline TCR sequences or is imposed by thymic selection was addressed here by induc
Costimulatory effect of IL-12 on the activation of naive, memory CD4+ T cells, and Th1 clone.: Cell Immunol. 1997 Feb 25;176(1):50-8. Unique Identifier : AIDSLINE MED/97223496; Kato T; Morokata T; Igarashi O; Yee ST; Inobe M; Uede T; Azuma M; Okumura K; Nariuchi H; Department of Allergology, Institute of Medical Science, University of; Tokyo, Japan.; In the present experiments, costimulatory effects of interleukin 12 (IL-12) and B7-2 on interleukin 2 receptor alpha chain (IL-2R alpha) expression and IL-2-dependent proliferation of naive and memory CD4+ T cells were studied in comparison with the effect of these molecules on Th1 clones. The naive and memory T cells
What is new in clinical research of viral diseases of the skin.: Dermatol Clin. 1997 Jan;15(1):189-96. Unique Identifier : AIDSLINE MED/97155157; Walther RR; Department of Dermatology, College of Physicians and Surgeons,; Columbia University, New York, New York, USA.; Viral diseases of the skin have become a much more serious problem with the increasing number of patients immunosuppressed by either AIDS or cancer chemotherapy. The emphasis in research on the diagnosis and treatment of these diseases is similar to that on the bacterial diseases several decades ago.
Gender differences in characteristics, infection control practices, knowledge and attitudes related to HIV among Ontario dentists.: Community Dent Oral Epidemiol. 1996 Dec;24(6):412-5. Unique Identifier : AIDSLINE MED/97159844; McCarthy GM; MacDonald JK; Faculty of Dentistry, University of Western Ontario, London, Canada.; We surveyed 5,997 dentists in Ontario to investigate gender differences in the characteristics, infection control practices, knowledge and attitudes regarding the treatment of HIV-infected patients. The response rate was 70.3%. Reports indicated that female dentists are younger and more likely to work in larger urban
Alcoholism, a contagious disease. A contribution towards an anthropological definition of contagion.: Cult Med Psychiatry. 1996 Dec;20(4):473-87. Unique Identifier : AIDSLINE MED/97144153; Fainzang S; National Institute of Health and Medical Research, INSERM, Paris.; The goal of this article is to show, from the discourses of drinkers spouses, members of a cured-drinkers movement in France very different from the AA, what the idea of the contagious character of alcoholism means in the subjects representations and by extension, what the idea
Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence.: Drug Metab Dispos. 1996 Dec;24(12):1298-306. Unique Identifier : AIDSLINE MED/97126210; Lin JH; Chiba M; Chen IW; Nishime JA; Vastag KJ; Drug Metabolism I, Merck Reserch Laboratories, West Point, PA 19486,; USA.; Indinavir , a potent and specific inhibitor of human immunodeficiency virus protease, is used for the treatment of AIDS. This study was designed to investigate the sex-related differences in kinetics and metabolism of indinavir in rats, dogs, and monke
Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans.: Drug Metab Dispos. 1996 Dec;24(12):1389-94. Unique Identifier : AIDSLINE MED/97126223; Balani SK; Woolf EJ; Hoagland VL; Sturgill MG; Deutsch PJ; Yeh KC; Lin JH; Department of Drug Metabolism, Merck Research Laboratories, West; Point, PA 19486, USA.; Indinavir , N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-tertiary- butylaminocarbonyl-4-(3-pyridylmethyl)piperazino]-4(S)- hydroxy-2(R)-phenylmethylpentanamide (L-735,524,MK-639, ayl-4- Crixivan
Characterization of intermediates in the oxidation of zinc fingers in human immunodeficiency virus type 1 nucleocapsid protein P7.: Drug Metab Dispos. 1996 Dec;24(12):1395-400. Unique Identifier : AIDSLINE MED/97126224; Hathout Y; Fabris D; Han MS; Sowder RC 2nd; Henderson LE; Fenselau C; Structural Biochemistry Center, University of Maryland Baltimore; County, 21250, USA.; Oxidants targeted toward inactivation of the nucleocapsid zinc finger protein are under development as antiviral agents, especially for use against human immunodeficiency virus. In the present study, electrospray ionization-mass spectrometry is used to follow in situ the progress of the reactions of 2,2 -dithiodipyrid
Psychopathology and HIV risk behaviors among injection drug users in and out of treatment.: Drug Alcohol Depend. 1996 Dec 2;43(1-2):1-11. Unique Identifier : AIDSLINE MED/97116050; Dinwiddie SH; Cottler L; Compton W; Abdallah AB; Washington University School of Medicine, Department of Psychiatry,; St. Louis, MO 63110-1093, USA.; To replicate prior descriptions of injection drug users (IDUs), 158 IDUs recruited via a street-outreach program were compared to 320 non-IDUs on measures of substance use, lifetime psychopathology, and HIV risk behavior. IDUs were more likely to receive a diagnosis of antisocial personality disorder, but not other ps
Lack of a pharmacologic interaction between rifabutin and methadone in HIV-infected former injecting drug users.: Drug Alcohol Depend. 1996 Dec 2;43(1-2):71-7. Unique Identifier : AIDSLINE MED/97116057; Brown LS; Sawyer RC; Li R; Cobb MN; Colborn DC; Narang PK; Addiction Research and Treatment Corporation, Brooklyn, NY 11201, USA.; Rifampin, an agent known to decrease the half-life of methadone, and rifabutin are two rifamycins that are structurally similar and share mechanisms of action. Hence the possibility of a drug-drug interaction between rifabutin and methadone was evaluated in 24 methadone-maintained, former injecting drug users infected
[Does methadone lessen HIV risk behavior?]: Dtsch Med Wochenschr. 1997 Feb 21;122(8):A7-8. Unique Identifier : AIDSLINE MED/97232157; Mader U
Drug treatment of HIV-related opportunistic infections.: Drugs. 1997 Jan;53(1):40-73. Unique Identifier : AIDSLINE MED/97163893; Klepser ME; Klepser TB; Division of Clinical and Administrative Pharmacy, College of Pharmacy,; University of Iowa, Iowa City 52242-1112, USA.; michael_klepser@uiowa.edu; The AIDS epidemic has led to the emergence of several disease entities which in the pre-AIDS era were rare or seemingly innocuous. Experience of treating these diseases varies. In some instances, such as Pneumocystis carinii pneumonia, there is an abundance of published literature to direct our course of action. Howev
Microsporidium-associated sinusitis.: Ear Nose Throat J. 1997 Feb;76(2):95-101. Unique Identifier : AIDSLINE MED/97198654; Moss RB; Beaudet LM; Wenig BM; Nelson AM; Firpo A; Punja U; Scott TS; Kaliner MA; Allergic Disease Section, NIAID, NIH, Bethesda, Maryland, USA.; Two cases of biopsy-proven Microsporidium-associated chronic sinusitis in HIV-seropositive patients are presented. Spores of Septata intestinalis were identified by light microscopy and confirmed by electron microscopy in each case. Both patients displayed severe deficiencies of nasal mucosa CD4-positive cells, demons
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling.: EMBO J. 1997 Feb 17;16(4):673-84. Unique Identifier : AIDSLINE MED/97201511; Iafrate AJ; Bronson S; Skowronski J; Department in Molecular Genetics and Microbiology, SUNY at Stony; Brook, NY 11794, USA.; The Nef protein alters T cell receptor (TCR) signaling in T cells and is critical for the pathogenesis of AIDS. We used a transient expression assay in a human CD4+ T cell line to analyze the interaction of Nef with the TCR machinery. We show that, in addition to down-regulating CD4 expression on the cell surface, Nef
The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budding in MDCK cells.: EMBO J. 1997 Feb 17;16(4):695-705. Unique Identifier : AIDSLINE MED/97201513; Lodge R; Lalonde JP; Lemay G; Cohen EA; Departement de Microbiologie et Immunologie, Universite de; Montreal,Quebec, Canada.; Budding of retroviruses from polarized epithelial Madin-Darby canine kidney cells (MDCK) takes place specifically at the basolateral membrane surface. This sorting event is suspected to require a specific signal harbored by the viral envelope glycoprotein and it was previously shown that, as for most basolateral prote
[AIDS in Mexico and the world: a global view]: Gac Med Mex. 1996;132 Suppl 1:1-138. Unique Identifier : AIDSLINE MED/97171767; Soberon-Acevedo G; Vilar-Puig P; Ramon de la Fuente J; Izazola-Licea JA; Mann JM; Cowal SG; Zacarias F; Liguori AL; Romero-Keith J; Tapia-Conyer R; Sepulveda J; Bronfman M; Rico B; Mohar A; Langer A; Ponce de Leon-Rosales S; Rangel-Frausto MS; Vazguez de-la-Serna A; Huertas M; Martinez-Abaroa C; Munoz-Hernandez O; Zarate-Aguilar A; Garduno-Espinosa J; Zuniga-Avila J; Mendoza-Zepeda R; et al; Fundacion Mexicanaparala Salud, Tepepan, Mexico, D.F.
Influence of hydrogen peroxide on the in vitro infectivity of human immunodeficiency virus.: Free Radic Biol Med. 1996;20(4):573-7. Unique Identifier : AIDSLINE MED/97059977; Ranjbar S; Holmes H; National Institute for Biological Standard and Controls, South Mimms,; Potters Bar, Herts, UK.; The object of this study was to investigate the influence of reactive oxygen intermediates (ROI), such as H2O2, on HIV-1 infection of cell cultures. The CD4+ HeLa human epithelial carcinoma cell line clone pBKTRLac was infected with HIV-1MN that had been treated with 0.01-5mM H2O2. Virus infectivity was detected by 3
[Efficacy of 2 combined drugs for HIV infected patients (news)]: Fortschr Med. 1996 Dec 10;114(34):61. Unique Identifier : AIDSLINE MED/97151932
HIV-2 prevalence in Uttar Pradesh.: Indian J Med Res. 1996 Mar;103:131-3. Unique Identifier : AIDSLINE MED/97215706; Kulshreshtha R; Mathur A; Chattopadhya D; Chaturvedi UC; Postgraduate Department of Microbiology, K.G. Medical College,; Lucknow.; Serum samples collected since 1989 with various patterns of reactivity for human immunodeficiency virus (HIV)-1, on the basis of screening ELISA and confirmatory Western blot (WB) test, were subjected to the detection of HIV-2 infection based on screening dot immunoassay and confirmatory WB for HIV-2. Significant prev
HIV encephalopathy.: Indian Pediatr. 1996 Oct;33(10):863-5. Unique Identifier : AIDSLINE MED/97210310; Shroff RC; Merchant RH; Gilada IS; Department of Pediatric Medicine, B.J. Wadia Hospital for Children,; Parel, Bombay.
Quantitative molecular monitoring of HIV-1 RNA during antiretroviral therapy.: Infection. 1996 Nov-Dec;24(6):412-8. Unique Identifier : AIDSLINE MED/97160071; Lafeuillade A; Poggi C; Pellegrino P; Profizi N; Dept. of Infectious Diseases, Hopital Chalucet, Toulon, France.; Plasma HIV-1 RNA testing was used to monitor 43 HIV-1 infected patients newly placed on antiretroviral therapy or whose therapy had been recently changed. A polymerase chain reaction kit was used to measure HIV-1 RNA in clinical samples or frozen plasma. The cutoff of this test was 200 RNA copies/ml. The first group 1
Zidovudine resistance mutations and human immunodeficiency virus type 1 DNA burden: longitudinal evaluation of six patients under treatment.: Infection. 1996 Nov-Dec;24(6):419-25. Unique Identifier : AIDSLINE MED/97160072; Zazzi M; Catucci M; De Milito A; Romano L; Venturi G; Almi P; Gonnelli A; Rubino M; Valensin PE; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; Zidovudine (ZDV) is by far the most widely used drug to counteract human immunodeficiency virus type 1 (HIV-1) infection, both in monotherapy and in combination therapy regimens. However, the majority of patients under prolonged ZDV therapy have been shown to harbour H
High prevalence of opportunistic infections in the head and neck related to human immunodeficiency virus. A prospective study of the distribution of otorhinolaryngologic disorders in 250 patients.: Infection. 1996 Nov-Dec;24(6):440-6. Unique Identifier : AIDSLINE MED/97160076; Riederer AP; Grein GO; Bogner JR; Klinik und Poliklinik fur Hals-, Nasen- und Ohrenkranke,; Ludwig-Maximilians-Universitat Munchen, Germany.
Women as dental patients: are there any gender differences?: Int Dent J. 1996 Dec;46(6):548-57. Unique Identifier : AIDSLINE MED/97176005; Zakrzewska JM; Department of Oral Medicine, St Bartholomew's, London, UK.; There is an increasing awareness that gender differences affect both health and disease. This review looks at gender differences as they pertain to the mouth. Not only does pregnancy, the menstrual cycle and the menopause affect the oral tissues but there are also gender differences in regard to patterns of dental dis
[Focusing on therapy of systemic mycoses]: Internist (Berl). 1995 Dec;36(12 Suppl):1-12. Unique Identifier : AIDSLINE MED/97174723
[News in the therapy of onychomycoses (Itraconazole)]: Hautarzt. 1995 Nov;46(11 Suppl):1-8. Unique Identifier : AIDSLINE MED/97174718
Detection of HBsAg and HIV carriage among blood donors or rural population of Loni areas.: J Assoc Physicians India. 1995 May;43(5):378. Unique Identifier : AIDSLINE MED/97076564; Jain RC; Soni SB
Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter.: J Biol Chem. 1997 Feb 21;272(8):4953-8. Unique Identifier : AIDSLINE MED/97184143; Dittmer J; Pise-Masison CA; Clemens KE; Choi KS; Brady JN; Virus Tumor Biology Section, Laboratory of Molecular Virology, NCI,; National Institutes of Health, Bethesda, Maryland 20892-5005, USA.; We have previously shown that the parathyroid hormone-related protein (PTHrP) promoter contains binding sites for transcription factors Ets1 and Sp1 and that human T-cell lymphotropic virus type I (HTLV-I) Tax cooperates with Ets1 to transactivate the PTHrP P2 promoter. Using the yeast two-hybrid interaction system, w
Analysis of PCR as a tool for detection of JC virus DNA in cerebrospinal fluid for diagnosis of progressive multifocal leukoencephalopathy.: J Clin Microbiol. 1996 Dec;34(12):2929-32. Unique Identifier : AIDSLINE MED/97095003; Hammarin AL; Bogdanovic G; Svedhem V; Pirskanen R; Morfeldt L; Grandien M; Department of Virology, Swedish Institute for Infectious Disease; Control, Stockholm, Sweden.; Two polyomaviruses, JC virus (JCV) and BK virus (BKV), affect humans. JCV is the causative agent of progressive multifocal leukoencephalopathy (PML), and detection of JCV in the central nervous system (CNS) is a prerequisite for confirmation of the disease. BKV is generally not associated with neurological disease, bu
Evaluation of the Digene Hybrid Capture System for detection and quantitation of human cytomegalovirus viremia in human immunodeficiency virus-infected patients.: J Clin Microbiol. 1996 Dec;34(12):2959-62. Unique Identifier : AIDSLINE MED/97095009; Mazzulli T; Wood S; Chua R; Walmsley S; Department of Microbiology, University of Toronto, Mount Sinai; Hospital, Ontario, Canada.; The Digene Hybrid Capture System (DHCS) is a solution hybridization antibody capture assay for the chemiluminescent detection and quantitation of cytomegalovirus ( CMV ) DNA in leukocytes. This assay was compared with the CMV a
Multicenter comparison of three commercial methods for quantification of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1996 Dec;34(12):3016-22. Unique Identifier : AIDSLINE MED/97095020; Schuurman R; Descamps D; Weverling GJ; Kaye S; Tijnagel J; Williams I; van Leeuwen R; Tedder R; Boucher CA; Brun-Vezinet F; Loveday C; Eijkman Winkler Institute for Medical Microbiology, Department of; Virology, Utrecht University, The Netherlands. r.schuurman@lab.azu.nl; Three procedures for the quantification of human immunodeficiency virus type 1 (HIV-1) RNA from plasma were compared at three laboratories. The comparison involved the Quantiplex branched DNA assay (version 1.0) by Chiron Diagnostics, the NASBA-QT assay by Organon Teknika, and the Amplicor Monitor assay by Roche Molec
Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus.: J Clin Microbiol. 1996 Dec;34(12):3180-4. Unique Identifier : AIDSLINE MED/97095047; Poland AM; Vennema H; Foley JE; Pedersen NC; Center for Companion Animal Health, School of Veterinary Medicine,; University of California, Davis 95616, USA.; Two groups of cats were experimentally infected orally with the cat-passaged RM strain of feline enteric coronavirus (FECV-RM). One group of cats (n = 19) had been chronically infected with feline immunodeficiency virus (FIV) for over 6 years, while a second control group (n = 20) consisted of FIV-naive siblings. Feca
An enhanced-sensitivity branched-DNA assay for quantification of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1996 Dec;34(12):3196-202. Unique Identifier : AIDSLINE MED/97095050; Kern D; Collins M; Fultz T; Detmer J; Hamren S; Peterkin JJ; Sheridan P; Urdea M; White R; Yeghiazarian T; Todd J; Chiron Corporation, Emeryville, California 94608-2916, USA.; The quantification of human immunodeficiency virus type 1 (HIV-1) RNA has facilitated clinical research and expedited the development of antiretroviral drugs. The branched-DNA (bDNA) assay provides a reliable method for the quantification of HIV-1 RNA in human plasma and is considered one of the most reproducible assa
Comparative evaluation of three antifungal susceptibility test methods for Candida albicans isolates and correlation with response to fluconazole therapy.: J Clin Microbiol. 1996 Dec;34(12):3208-11. Unique Identifier : AIDSLINE MED/97095053; Ruhnke M; Schmidt-Westhausen A; Engelmann E; Trautmann M; Abteilung Innere Medizin and Poliklinik, Virchow-Klinikum,; Humboldt-Universitat, Berlin, Germany. mruhnke@.ukrv.de; In vitro susceptibilities were determined for 56 Candida albicans isolates obtained from the oral cavities of 41 patients with human immunodeficiency virus infection. The agents tested included fluconazole, itraconazole, ketoconazole, flucytosine, and amphotericin B. MICs were determined by the broth microdilution tec
Detection of the microsporidian parasite Enterocytozoon bieneusi in specimens from patients with AIDS by PCR.: J Clin Microbiol. 1996 Dec;34(12):3230-2. Unique Identifier : AIDSLINE MED/97095059; Velasquez JN; Carnevale S; Guarnera EA; Labbe JH; Chertcoff A; Cabrera MG; Rodriguez MI; Department of Parasitology, National Institute of Microbiology, Dr.; Carlos G. Malbran, Buenos Aires, Argentina. parasito@malbra.sld.ar; Microsporidia are protozoa parasites responsible for significant gastrointestinal disease in patients infected with human immunodeficiency virus. We evaluated a PCR assay of stool samples, duodenal aspirates, and biopsy specimens from patients with Enterocytozoon bieneusi infection. A 210-bp DNA fragment of the unique
Interest of quantitative pp65 cytomegalovirus antigenemia assay for human immunodeficiency virus-positive patients [letter; comment]: J Clin Microbiol. 1996 Dec;34(12):3255-6. Unique Identifier : AIDSLINE MED/97095070; Ranger-Rogez S; Couty JP; Nicot T; Denis F; Rogez JP; Riche A; Weinbreck P
Changes in the distribution of cells expressing tumour-associated antigen in lymph nodes during the progression of enzootic bovine leukosis.: J Comp Pathol. 1996 Nov;115(4):343-52. Unique Identifier : AIDSLINE MED/97157798; Koguchi A; Chiba T; Hiraga M; Hasuta Y; Tsujimoto T; Furusato K; Goryo M; Davis WC; Aida Y; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Morioka, Japan.; A monoclonal antibody (MAb), c143, that recognizes a tumour-associated antigen that is upregulated on neoplastic B cells in cattle with enzootic bovine leukosis (EBL), was used as a marker to study disease progression. An immunohistochemical examination of neoplastic tissue and superficial cervical lymph nodes from
The anti-HIV-1 activity associated with saliva.: J Dent Res. 1997 Feb;76(2):634-40. Unique Identifier : AIDSLINE MED/97216299; Shine N; Konopka K; Duzgunes N; Department of Microbiology, University of the Pacific, School of; Dentistry, San Francisco, California 94115-2399, USA.; This review summarizes the data on the anti-human immunodeficiency virus (HIV) activity associated with saliva and the possible routes of oral transmission of HIV. Saliva can be passed from an HIV-infected individual to an uninfected person via sexual or non-sexual activities. The relative risk of HIV transmission thr
HIV/AIDS risk in heterosexual college students. A review of a decade of literature.: J Am Coll Health. 1997 Jan;45(4):147-58. Unique Identifier : AIDSLINE MED/97171832; Lewis JE; Malow RM; Ireland SJ; University of Miami/Jackson Memorial Medical Center, Florida, USA.; Empirical studies dealing with the psychosocial correlates of HIV risk among heterosexual college students are reviewed, including findings related to such theoretical variables as HIV/AIDS-related knowledge, personal and partner s attitudes toward condom use, perceived susceptibility, communication with sex partners,
Internalized homophobia in a sample of HIV+ gay men, and its relationship to psychological distress, coping, and illness progression.: J Homosex. 1996;32(2):91-106. Unique Identifier : AIDSLINE MED/97164081; Wagner G; Brondolo E; Rabkin J; New York State Psychiatric Institute (NYSPI), USA.; The purpose of this study was to determine whether internalized homophobia is related to psychological distress and coping style and whether these relationships are moderated by illness stage. A sample of gay men, most of whom were HIV+, Caucasian, and well educated, were administered assessments at both baseline and
Development of IFN-gamma-producing CD8+ gamma delta+ T lymphocytes and IL-2-producing CD4+ alpha beta+ T lymphocytes during contact sensitivity.: J Immunol. 1997 Mar 15;158(6):2567-75. Unique Identifier : AIDSLINE MED/97211821; Dieli F; Asherson GL; Sireci G; Dominici R; Scire E; Salerno A; Institute of General Pathology, University of Palermo, ISMEDA-CNR,; Italy.; This paper describes the development of Ag-specific proliferation and the production of IFN-gamma and IL-2 during contact sensitivity (CS) to the hapten picryl chloride (PCl). Lymph node cells from mice immunized with PCl proliferate and produce IFN-gamma and IL-2 when
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.: J Immunol. 1997 Mar 15;158(6):2648-53. Unique Identifier : AIDSLINE MED/97211830; Nakamura T; Lee RK; Nam SY; Podack ER; Bottomly K; Flavell RA; Section of Immunobiology, Yale University School of Medicine, Howard; Hughes Medical Institute, New Haven, CT 06520, USA.; It has previously been reported that Th1 CD4 T cell populations can be converted to IL-4 producers, whereas Th2 populations are refractory to IL-12-mediated IFN-gamma production. We have recently shown that CD30 is a marker for the IL-4 response and have therefore used CD30 here to study Th1 and Th2 commitment. We sho
Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals.: J Immunol. 1997 Mar 15;158(6):2654-62. Unique Identifier : AIDSLINE MED/97211831; Palmer EM; van Seventer GA; Department of Pathology, University of Chicago, IL 60637, USA.; We have developed an in vitro differentiation model for human Th cells to study the role of cytokines and accessory cell-dependent costimulatory signals in this process. Peripheral blood-derived CD4+ naive (CD45RA+ RO-) T cells were stimulated in weekly intervals with immobilized anti-CD3 mAb, accessory cells, and e
Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86.: J Immunol. 1997 Mar 15;158(6):2713-22. Unique Identifier : AIDSLINE MED/97211838; Schweitzer AN; Borriello F; Wong RC; Abbas AK; Sharpe AH; Department of Pathology, Brigham & Women's Hospital, Harvard Medical; School, Boston, MA 02115, USA.; For T cells to be optimally activated, recognition of Ag/MHC complexes by the TCR must be accompanied by a second, costimulatory signal that can be provided efficiently by the related costimulatory molecules CD80 (B7-1) and CD86 (B7-2). Recently, CD80 and CD86 have been implicated as differential determinants of Th1-
Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 CD95)-induced apoptosis and preservation of a T helper 1 phenotype.: J Immunol. 1997 Mar 15;158(6):2964-76. Unique Identifier : AIDSLINE MED/97211869; Gougeon ML; Lecoeur H; Boudet F; Ledru E; Marzabal S; Boullier S; Roue R; Nagata S; Heeney J; Department of AIDS and Retroviruses, Pasteur Institute, Paris, France.; Chimpanzees are one of the few species, along with humans, susceptible to persistent HIV-1 infection. However, HIV-infected chimpanzees do not exhibit the marked immune system alterations seen in humans and remain relatively resistant to AIDS. In humans, HIV infection leads to unresponsiveness of T cells in response t
The integrin-triggered rescue of T lymphocyte apoptosis is blocked in HIV-1-infected individuals.: J Immunol. 1997 Mar 15;158(6):2984-99. Unique Identifier : AIDSLINE MED/97211871; Ng TT; Kanner SB; Humphries MJ; Wickremasinghe RG; Nye KE; Anderson J; Khoo SH; Morrow WJ; Department of Immunology, St. Bartholomew's and Royal London School of; Medicine and Dentistry, United Kingdom.; HIV infection is associated with a disease status-dependent impairment of Ag-specific T cell responses, resulting in anergy or unchecked apoptotic cell death. beta1 integrins play an important role in the induction of T lymphocyte responses to antigenic challenge by providing a T cell costimulatory signal, and have be
Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease.: J Immunol. 1997 Mar 15;158(6):3009-16. Unique Identifier : AIDSLINE MED/97211873; Segal R; Bermas BL; Dayan M; Kalush F; Shearer GM; Mozes E; Department of Immunology, The Weizmann Institute of Science, Rehovot,; Israel.; We followed cytokine production from induction through disease progression in a murine model of experimental systemic lupus erythematosus (SLE). SLE was induced by immunization with the human monoclonal anti-DNA Ab that bears the common Id designated 16/6 Id. BALB/c and C3H.SW mice that are susceptible to SLE inductio
A malignant astrocytoma in a patient with AIDS: a possible association between astrocytomas and HIV infection.: J Infect. 1996 Nov;33(3):159-62. Unique Identifier : AIDSLINE MED/97101176; Neal JW; Llewelyn MB; Morrison HL; Jasani B; Borysiewicz LK; Department of Histopathology, University Hospital of Wales, College of; Medicine, Cardiff, U.K.; We describe a malignant astrocytoma in a patient with AIDS confirmed at autopsy. The object of this report is to draw attention to a further example of an unusual tumour associated with HIV infection. This is the tenth case in the world literature and it is possible that this tumour is represented with a higher than e
A comparison of two methods of gene amplification for the diagnosis of Toxoplasma gondii in AIDS.: J Infect. 1996 Nov;33(3):177-83. Unique Identifier : AIDSLINE MED/97101180; Nicoll S; Burns SM; Brettle RP; Leen CS; Centre for Tropical Veterinary Medicine, Edinburgh University, Roslin,; Midlothian, U.K.
Response to oral and intravenous azithromycin in a patient with toxoplasma encephalitis and AIDS.: J Infect. 1996 Nov;33(3):227-9. Unique Identifier : AIDSLINE MED/97101188; Wiselka MJ; Read R; Finch RG; Department of Infectious Diseases and Tropical Medicine, Leicester; Royal Infirmary, U.K.; We present a patient with AIDS and toxoplasma encephalitis who was unable to tolerate established therapy with sulphadiazine or clindamycin but responded to oral azithromycin and pyrimethamine. The patient was maintained on oral azithromycin but subsequently relapsed after 8 months. The recurrence was successfully tre
Cryptococcal dermatitis with negative antigenaemia heralding disseminated disease in HIV infection [letter]: J Infect. 1996 Nov;33(3):240-1. Unique Identifier : AIDSLINE MED/97101192; Soldani F; Lanzafame M; Allegranzi B; Bonora S; Tessari G; Di Perri G; Concia E
Cytokine production by dengue virus antigen-responsive human T lymphocytes in vitro examined using a double immunocytochemical technique.: J Leukoc Biol. 1997 Mar;61(3):338-45. Unique Identifier : AIDSLINE MED/97213768; Mori M; Kurane I; Janus J; Ennis FA; Department of Medicine, University of Massachusetts Medical School,; Worcester 01655, USA.; A number of studies suggest that cytokines may contribute to the pathogenesis of viral infections, including dengue. In this study, we developed a double immunocytochemical method and characterized cytokine-producing cells in the peripheral blood mononuclear cells (PBMC) of dengue virus-immune donors after in vitro st
Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity.: J Leukoc Biol. 1997 Mar;61(3):346-52. Unique Identifier : AIDSLINE MED/97213769; Maruo S; Ahn HJ; Yu WG; Tomura M; Wysocka M; Yamamoto N; Kobayashi M; Hamaoka T; Trinchieri G; Fuijiwara H; Biomedical Research Center, Osaka University Medical School, Suita,; Japan.; We previously demonstrated that proliferation of terminally differentiated Th1 clones depends primarily on an interleukin-12 IL-12)-paracrine mechanism mediated by their interactions with antigen-presenting cells (APC) rather than on an IL-2-autocrine mechanism. Such a Th1 clone (4-86, C57BL/6 origin) was cultured wit
Virus load in chimpanzees infected with human immunodeficiency virus type 1: effect of pre-exposure vaccination.: J Gen Virol. 1995 Apr;76 ( Pt 4):1015-20. Unique Identifier : AIDSLINE MED/97201565; ten Haaft P; Cornelissen M; Goudsmit J; Koornstra W; Dubbes R; Niphuis H; Peeters M; Thiriart C; Bruck C; Heeney JL; Laboratory of Viral Pathogenesis, Biomedical Primate Research Centre,; Rijswijk, the Netherlands.; Many reports indicate that a long-term asymptomatic state following human immunodeficiency virus type 1 (HIV-1) infection is associated with a low amount of circulating virus. To evaluate the possible effect of stabilizing a low virus load by non-sterilizing pre-exposure vaccination, a quantitative virus isolation met
Human T cell leukaemia virus type I env gene-transfected HeLa cells display a decrease in cell fusion ability.: J Gen Virol. 1995 Apr;76 ( Pt 4):1021-4. Unique Identifier : AIDSLINE MED/97201566; Girerd Y; Casse H; Duc Dodon M; Gazzolo L; Immuno-Virologie Moleculaire et Cellulaire, UMR30, Centre National de; la Recherche Scientifique, Universite Claude Bernard Lyon I, France.; The envelope (env) gene of human T cell leukaemia virus type I HTLV-I) was inserted into an expression vector, referred to as phMTenv, under the transcriptional control of the human metallothionein IIa gene promoter (hMT-IIa). When this vector was transiently transfected in HeLa cells treated with hMT-IIa inducers, fo
The human immunodeficiency virus type 1 Nef protein functions as a protein kinase C substrate in vitro.: J Gen Virol. 1995 Apr;76 ( Pt 4):837-44. Unique Identifier : AIDSLINE MED/97201543; Coates K; Harris M; MRC Retrovirus Research Laboratory, Department of Veterinary; Pathology, University of Glasgow, UK.; The human immunodeficiency virus type 1 Nef protein was expressed in Escherichia coli as a C-terminal fusion with glutathione S-transferase (GST). The ability of GST-Nef to act as a substrate for cellular kinases in vitro was examined by incubation of purified GST-Nef fusion proteins, immobilized on glutathione-agaros
Revertants and pseudo-revertants of human immunodeficiency virus type 1 viruses mutated in the long terminal repeat promoter region.: J Gen Virol. 1995 Apr;76 ( Pt 4):845-53. Unique Identifier : AIDSLINE MED/97201544; Berkhout B; Klaver B; Department of Virology, University of Amsterdam Academic Medical; Centre, The Netherlands.; The TAR domain is an RNA secondary structure element within the leader transcript of the human immunodeficiency virus type 1 HIV-1) virus. TAR RNA forms the binding site for the viral trans-activator protein Tat and cellular co-factors that are involved in induction of the LTR transcriptional promoter. Here, we report
Coronavirus-induced encephalomyelitis: balance between protection and immune pathology depends on the immunization schedule with spike protein S.: J Gen Virol. 1995 Apr;76 ( Pt 4):873-9. Unique Identifier : AIDSLINE MED/97201547; Flory E; Stuhler A; Barac-Latas V; Lassmann H; Wege H; Institute of Virology and Immunobiology, University of Wurzburg,; Germany.; The neurotropic mouse hepatitis virus MHV-JHM induces central nervous system (CNS) demyelination in Lewis rats that pathologically resembles CNS lesions in multiple sclerosis. The mechanisms of MHV-JHM-induced demyelination remain unclear and several studies have implicated the role of the immune response in this proc
Adelaide River virus nucleoprotein gene: analysis of phylogenetic relationships of ephemeroviruses and other rhabdoviruses.: J Gen Virol. 1995 Apr;76 ( Pt 4):995-9. Unique Identifier : AIDSLINE MED/97201562; Wang Y; Cowley JA; Walker PJ; CSIRO Division of Tropical Animal Production, Indooroopilly,; Queensland, Australia.; The nucleotide sequence of the Adelaide River virus (ARV) genome was determined from the 3 terminus to the end of the nucleoprotein (N) gene. The 3 leader sequence comprises 50 nucleotides and shares a common terminal trinucleotide (3 UGC-), a conserved U-rich domain and a variable AU-rich domain with other animal
Long-term evolution of the 5'UTR and a region of NS4 containing a CTL epitope of hepatitis C virus in two haemophilic patients.: J Gen Virol. 1997 Mar;78 ( Pt 3):583-90. Unique Identifier : AIDSLINE MED/97201623; Devereux HL; Brown D; Dusheiko GM; Emery VC; Lee CA; The Haemophilia Centre, Haematology Department, Royal Free Hospital,; London, UK.; Haemophilic patients exposed to unsterilized clotting factor concentrates prior to 1985 have become infected with hepatitis C virus (HCV). We have studied the sequence evolution of the 5 UTR and a region of NS4 over 12 years in one human immunodeficiency virus (HIV) positive haemophilic patient and 14 years for one HI
Inhibition of feline immunodeficiency virus infection by CD9 antibody operates after virus entry and is independent of virus tropism.: J Gen Virol. 1997 Mar;78 ( Pt 3):611-8. Unique Identifier : AIDSLINE MED/97201626; Willett B; Hosie M; Shaw A; Neil J; Department of Veterinary Pathology, University of Glasgow, UK.; b.willett@vet.gla.ac.uk; A monoclonal antibody which blocks infection with feline immunodeficiency virus (FIV) was found previously to react with the cell surface molecule CD9, implicating CD9 in the process of virus entry. We report here that inhibition by anti-CD9 antibody does not operate at the level of virus entry but at a subsequent sta
Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.: J Gen Virol. 1997 Mar;78 ( Pt 3):619-25. Unique Identifier : AIDSLINE MED/97201627; Fujita K; Omura S; Silver J; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; Human immunodeficiency virus (HIV) type 1 encodes three genes, Vpu, Env and Nef, that decrease cellular CD4. Vpu and Env act cooperatively to accelerate degradation of CD4 in the endoplasmic reticulum. Here we report that Vpu/Env-induced CD4 degradation is inhibited by lactacystin, a specific inhibitor of the proteaso
Analysis of vif-defective human immunodeficiency virus type 1 HIV-1) virions synthesized in 'non-permissive' T lymphoid cells stably infected with selectable HIV-1.: J Gen Virol. 1997 Mar;78 ( Pt 3):627-35. Unique Identifier : AIDSLINE MED/97201628; Ochsenbauer C; Wilk T; Bosch V; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.; In order to facilitate analyses of the molecular function of the human immunodeficiency virus type 1 (HIV-1) Vif protein, we have developed a cell culture model-system which allows permanent production of genotypically and phenotypically vif-defective HIV-1 virions in non-permissive H9 cells. Using recombinant, repl
The major homology region of bovine leukaemia virus p24gag is required for virus infectivity in vivo.: J Gen Virol. 1997 Mar;78 ( Pt 3):637-40. Unique Identifier : AIDSLINE MED/97201629; Willems L; Kerkhofs P; Attenelle L; Burny A; Portetelle D; Kettmann R; Molecular Biology Unit, Faculty of Agronomy, Gembloux, Belgium.; In order to gain insight into the role of the major homology region (MHR) in the infectious potential of bovine leukaemia virus (BLV), mutations were introduced into the capsid gene of an infectious molecular clone. A provirus that was designed to contain only a slightly modified version of the MHR (substitution of ph
Molecular subtyping of human T-lymphotropic virus type I (HTLV-I) by a nested polymerase chain reaction-restriction fragment length polymorphism analysis of the envelope gene: two distinct lineages of HTLV-I in Taiwan.: J Med Virol. 1997 Jan;51(1):25-31. Unique Identifier : AIDSLINE MED/97140464; Yang YC; Hsu TY; Liu MY; Lin MT; Chen JY; Yang CS; Graduate Institute of Microbiology, College of Medicine, National; Taiwan University, Republic of China.; The major type of human T-lymphotropic virus type I (HTLV-I), generally referred to as the cosmopolitan type, has been grouped into three subtypes (A, B, and C) by phylogenetic analysis of the long terminal repeat sequences of the viral genome. Twelve subtype-specific nucleotide variations have been deduced by compari
Hepatitis C virus genotypes in French haemophiliacs: kinetics and reappraisal of mixed infections.: J Med Virol. 1997 Jan;51(1):36-41. Unique Identifier : AIDSLINE MED/97140466; Tuveri R; Rothschild C; Pol S; Reijasse D; Persico T; Gazengel C; Brechot C; Thiers V; INSERM U370, Chu Necker and CBMS, Pasteur Institue, Paris, France.; The distribution and kinetics of hepatitis C virus (HCV) genotypes and the prevalence of mixed infections were studied in a group of 45 French patients with haemophilia A or B or von Willebrand s disease, 21 of them being anti-human immunodeficiency virus (HIV) positive; genotyping was carried out by three methods bas
Comparison between vaginal tampon and cervicovaginal lavage specimen collection for detection of human papillomavirus DNA by the polymerase chain reaction. The Canadian Women's HIV Study Group.: J Med Virol. 1997 Jan;51(1):42-7. Unique Identifier : AIDSLINE MED/97140467; Coutlee F; Hankins C; Lapointe N; Department de Microbiologie-Immunologie, Universite de Montreal,; Quebec, Canada.; The aim of the study was to compare the accuracy of self-administered vaginal tampon (VT) specimens for the detection of human papillomaviruses (HPVs) with that of cervicovaginal lavage specimens (CVL). Two hundred seventy-four paired VT and CVL specimens were collected prospectively from women at risk of sexually tra
Additional mutations detected in sequential HIV-1 isolates from ZDV-treated patients.: J Med Virol. 1997 Jan;51(1):48-55. Unique Identifier : AIDSLINE MED/97140468; Magierowska-Jung M; Agut H; Katlama C; Autran B; Huraux JM; Laboratoire de Virologie CNRS EP 57. CERVI, Hopital Pitie-Salpetriere,; Paris, France.; Sequential isolates from four patients under zidovudine (ZDV) therapy were obtained using PBMC coculture in the absence or in the presence of 0.25 microM ZDV. PBMC-based HIV susceptibility assay demonstrated the emergence of ZDV-resistance in the sequential isolates from the four patients. Except in one case, the isol
Improved methods for quantification of human immunodeficiency virus type 1 RNA and hepatitis C virus RNA in blood using spin column technology and chemiluminescent assays of PCR products.: J Med Virol. 1997 Jan;51(1):56-63. Unique Identifier : AIDSLINE MED/97140469; Lin HJ; Tanwandee T; Hollinger FB; Division of Molecular Virology, Baylor College of Medicine, Houston,; Texas 77030, USA.; The quantification of human immunodeficiency virus type 1 (HIV-1) RNA or hepatitis C virus (HCV) RNA has been facilitated by adapting a spin column procedure for sample preparation and the use of chemiluminescent detection of polymerase chain reaction PCR) products in microtiter plate format. All materials were commer
Temporary seronegativity in a human immunodeficiency virus type 1-infected man.: J Med Virol. 1997 Jan;51(1):80-2. Unique Identifier : AIDSLINE MED/97140472; Zaaijer HL; Bloemer MH; Lelie PN; Clinical Microbiology and Infection Control, University Hospital Vrije; Universiteit, Amsterdam, The Netherlands.; Over a period of 3 months a human immunodeficiency virus 1 HIV-1)-infected patient showed a sequence of positive-negative-positive anti-HIV screening test results. During this period the level of HIV p24 antigen declined and the HIV antibody pattern by Western blot gradually became complete, suggesting recent HIV infe
Fatal brain stem encephalitis due to herpes simplex virus type 1 in AIDS [letter]: J Neurol. 1996 Jun;243(6):491-3. Unique Identifier : AIDSLINE MED/96396724; Moulignier A; Baudrimont M; Martin-Negrier ML; Mikol J; Lapresle C; Dupont B
A comparison of brain biopsy and CSF-PCR in the diagnosis of CNS lesions in AIDS patients.: J Neurol. 1997 Jan;244(1):35-9. Unique Identifier : AIDSLINE MED/97160227; d'Arminio Monforte A; Cinque P; Vago L; Rocca A; Castagna A; Gervasoni C; Terreni MR; Novati R; Gori A; Lazzarin A; Moroni M; Infectious Diseases Clinic, L Sacco Hospital, Milan, Italy.; Twenty patients with AIDS who had intracranial lesions underwent both brain biopsy and cerebrospinal fluid (CSF) examination to compare histological diagnosis with the polymerase chain reaction CSF-PCR) for the identification of infectious agents. CSF-PCR was performed for herpes simplex virus, varicella zoster virus,
Mitoguazone therapy in patients with refractory or relapsed AIDS-related lymphoma: results from a multicenter phase II trial.: J Clin Oncol. 1997 Mar;15(3):1094-103. Unique Identifier : AIDSLINE MED/97213861; Levine AM; Tulpule A; Tessman D; Kaplan L; Giles F; Luskey BD; Scadden DT; Northfelt DW; Silverberg I; Wernz J; Espina B; Von Hoff D; University of Southern California School of Medicine, Los Angeles; 90033, USA. hornor@hsc.usc.edu; PURPOSE: Patients with AIDS-related lymphoma usually have extensive lymphomatous disease, with relatively frequent involvement of the CNS. Approximately half may achieve complete remission after chemotherapy. Mitoguazone, an inhibitor of polyamine biosynthesis, has demonstrated efficacy in patients with de novo recurr
AIDS-related Kaposi's sarcoma.: J Clin Oncol. 1997 Mar;15(3):1283-4. Unique Identifier : AIDSLINE MED/97213884; van den Brink MR; Dezube BJ; AIDS Malignancy Research and Treatment Center, Beth Israel Deaconess; Medical Center, Boston, MA, USA.
In vitro inhibitory activity of citreoviridin against HIV-1 and an HIV-associated opportunist: Candida albicans.: J Chemother. 1996 Oct;8(5):351-7. Unique Identifier : AIDSLINE MED/97116626; Vieta I; Savarino A; Papa G; Vidotto V; Cantamessa C; Pugliese A; Department of Medical and Surgical Sciences, University of Turin,; Italy.; Citreoviridin, a mycotoxin produced by some molds of the genera Penicillium and Aspergillus, inhibits the growth of bacteria of the Bacillus genus. Since significant information was not available on the effects of citreoviridin on eukaryotic cells and viruses, this molecule was tested on CD4+ T-lymphoid cell lines, on
Experience with adriamycin, bleomycin, vincristine (ABV) palliative chemotherapy in advanced AIDS-related Kaposi's sarcoma.: J Chemother. 1996 Oct;8(5):403-6. Unique Identifier : AIDSLINE MED/97116635; Paparizos VA; Kyriakis KP; Mileounis KA; Pfandl-Polydorou D; Stavrianeas NG; Vareltzidis AG; Stratigos JD; Dept. of Dermatology, Andreas Sygros Hospital, University of Athens,; Greece.; After administration of Adriamycin, bleomycin, vincristine (ABV) as palliative chemotherapy in advanced AIDS-related Kaposi s sarcoma (AIDS.KS) patients with low Karnosfsky performance scores, the authors attempted to estimate the overall biological cost/benefit relating to the disease. The authors analyzed data from
The actions of polynucleotides on effector stage cloned murine T-helper cells differ in each subset and depend on antigen concentration.: J Nutr. 1997 Mar;127(3):411-7. Unique Identifier : AIDSLINE MED/97228054; Jyonouchi H; Sun S; Department of Pediatrics, School of Medicine, University of Minnesota,; Minneapolis 55455, USA.; Polynucleotides enhance T-helper (Th) cell-mediated humoral immune responses in naive resting Th cells, B cells, and antigen-presenting cells (APC) from unprimed mouse spleen. If polynucleotides augment Th cell functions independent of the activation stage of Th cells, then polynucleotides may cause hyperimmune respon
Apoptosis of human monocytes/macrophages in Mycobacterium tuberculosis infection.: J Pathol. 1997 Jan;181(1):31-8. Unique Identifier : AIDSLINE MED/97225658; Placido R; Mancino G; Amendola A; Mariani F; Vendetti S; Piacentini M; Sanduzzi A; Bocchino ML; Zembala M; Colizzi V; Department of Biology University of Rome Tor Vergata, Italy.; Tuberculosis (TB) is still a major health problem, both as a single disease entity and as a cofactor in AIDS. The interaction between macrophage and Mycobacterium tuberculosis (MTB) is a critical step in the establishment of an early chronic infection. This study analyses the capacity of MTB to induce apoptosis in cel
Endoscopic retrograde cholangiopancreatography in children with HIV infection.: J Pediatr Gastroenterol Nutr. 1996 Dec;23(5):624-7. Unique Identifier : AIDSLINE MED/97138873; Yabut B; Werlin SL; Havens P; Bohorfoush A; Brown CW; Harb J; Department of Pediatrics (Division of Gastroenterology and Infectious; Diseases), Medical College of Wisconsin, Milwaukee 53226, USA.
Correlates of psychological distress among mothers of children and adolescents with hemophilia and HIV infection.: J Pediatr Psychol. 1997 Feb;22(1):1-14. Unique Identifier : AIDSLINE MED/97171875; Drotar D; Agle DP; Eckl CL; Thompson PA; Case Western Reserve University School of Medicine, Cleveland, Ohio,; USA.; Evaluated the correlates of mood state (psychological distress) in a multisite study of two groups: (a) mothers of HIV-positive children and adolescents with hemophilia (n = 91), and (b) mothers of HIV-negative children and adolescents with hemophilia n = 92). Socioeconomic status, quality of family relationship suppo
Brief report: HIV-exposed newborns show inferior orienting and abnormal reflexes on the Brazelton Scale.: J Pediatr Psychol. 1997 Feb;22(1):105-12. Unique Identifier : AIDSLINE MED/97171882; Scafidi F; Field T; Touch Research Institute, University of Miami School of Medicine,; Florida 33101, USA.; Assessed 48 infants of HIV-positive and HIV-negative mothers on the Brazelton Neonatal Behavioral Assessment Scale. Infants exposed to HIV-positive mothers were disadvantaged from birth due to their mothers having obstetric complications and to the infants having orienting problems and abnormal reflexes on the Brazelt
Cell-mediated immunity in host resistance against infection caused by Penicillium marneffei.: J Med Vet Mycol. 1996 Nov-Dec;34(6):371-8. Unique Identifier : AIDSLINE MED/97126731; Kudeken N; Kawakami K; Kusano N; Saito A; First Department of Internal Medicine, Faculty of Medicine, University; of the Ryukyus, Okinawa, Japan.; Penicillium marneffei is one of the most important opportunistic infectious pathogens in AIDS patients in Thailand and Southeast Asia. However, very little is known about the host defence mechanisms against P. marneffei infection. In the present study, we established the first ex
Cladophialophora bantiana isolated from an AIDS patient with pulmonary infiltrates.: J Med Vet Mycol. 1996 Nov-Dec;34(6):427-9. Unique Identifier : AIDSLINE MED/97126739; Brenner SA; Morgan J; Rickert PD; Rimland D; Division of Infectious Disease, Emory University School of Medicine,; Atlanta, GA, USA.; Cladophialophora bantiana causes a rare phaeohyphomycosis, usually manifested by brain abscesses but rarely by skin or pulmonary lesions. It has not been reported as a common colonizer or as a cause of pulmonary symptoms in patients with AIDS. We present a case in which C. bantiana was repeatedly isolated from the spu
Oral cryptococcosis: case report of salivary gland involvement in an AIDS patient.: J Oral Pathol Med. 1997 Jan;26(1):53-6. Unique Identifier : AIDSLINE MED/97173655; Monteil RA; Hofman P; Michiels JF; Loubiere R; Laboratoire de Pathobiologie Orale, Universite de Nice, France.; Salivary cryptococcosis was disclosed at autopsy in an AIDS patient with disseminated C. neoformans infection. H & E staining was not suitable to demonstrate the occurrence of C. neoformans in many tissues; Alcian blue gave the best results.
Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site.: J Mol Biol. 1997 Feb 14;266(1):31-9. Unique Identifier : AIDSLINE MED/97207675; Ghiara JB; Ferguson DC; Satterthwait AC; Dyson HJ; Wilson IA; Department of Molecular Biology, Scripps Research Institute, La Jolla,; CA 92037, USA.; Antigenic variation among different HIV-1 isolates has been a major problem in the development of an effective vaccine against AIDS. Peptide vaccines incorporating structural elements common to groups of viral isolates, such as the clade subtypes of HIV-1, hold promise; however, the design of such immunogens has been
From the Centers for Disease Control and Prevention. Update: trends in AIDS incidence, deaths, and prevalence--United States, 1996.: JAMA. 1997 Mar 19;277(11):874-5. Unique Identifier : AIDSLINE MED/97216023
From the Centers for Disease Control and Prevention. Community-based HIV prevention in presumably underserved populations--July-September 1995.: JAMA. 1997 Mar 19;277(11):876-7. Unique Identifier : AIDSLINE MED/97216024
[Opportunistic lymphoma]: Nippon Rinsho. 1997 Feb;55(2):441-5. Unique Identifier : AIDSLINE MED/97198822; Katano H; Mori S; Department of Pathology, University of Tokyo.; Malignant lymphoma is one of the most common complications in patients under immunodeficiency. Such lymphomas, termed as opportunistic lymphoma, are growing in these days because of the high prevalence of AIDS and the wide introduction of organ/bone marrow transplantation. The Epstein-Barr virus has been regarded as t
[Current diagnosis and prognostic importance of EBV-associated neoplasms]: Nippon Rinsho. 1997 Feb;55(2):446-51. Unique Identifier : AIDSLINE MED/97198823; Kawa K; Osaka Medical Center.; In addition to endemic Burkitt s lymphoma and nasopharyngeal carcinoma a variety of other epithelial-and lymphoid-derived proliferative diseases has been shown to closely link with Epstein-Barr virus (EBV) infection. The former include thymic lymphoepithelial carcinoma, oral hairy leukoplakia and gastric carcinoma. Th
Pathology of acquired immunodeficiency syndrome (AIDS) in children.: Keio J Med. 1996 Dec;45(4):306-12. Unique Identifier : AIDSLINE MED/97175856; Joshi VV; Department of Pathology, Hartford Hospital, CT 06102, USA.; OVERVIEW: Acquired Immunodeficiency Syndrome (AIDS) was first described to occur in children in 1983. With experience of increasing number of cases of AIDS, pathologic lesions in various organs and tissues such as lungs, brain, G.I. tract, heart, blood vessels, lymph nodes, spleen, bone marrow, etc. became evident in
[Treatment of AIDS and associated diseases]: Klin Med (Mosk). 1997;75(1):5-10. Unique Identifier : AIDSLINE MED/97208338; Rytik PG; NII of Epidemiology and Microbiology, Minsk, Byelorussia.
Increased enzyme-linked immunosorbent assay specificity with solubilized simian retrovirus 2-infected cell membranes.: Lab Anim Sci. 1996 Dec;46(6):619-22. Unique Identifier : AIDSLINE MED/97154455; Thouless ME; Wang Y; Welch MJ; Department of Pathobiology, University of Washington, Seattle; 98195-7238, USA.; Simian type-D retrovirus (SRV) infection is a health problem in captive and wild-caught macaques; it interferes with acquired immune deficiency syndrome-related research. Because the enzyme-linked immunosorbent assay (ELISA) with gradient-purified SRV-2 virus yields a high percentage of false-positive results, the ass
Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations.: J Theor Biol. 1997 Jan 21;184(2):203-17. Unique Identifier : AIDSLINE MED/97212780; Nowak MA; Bonhoeffer S; Shaw GM; May RM; Department of Zoology, University of Oxford, U.K.; Anti-viral drug treatment of infections with the human immunodeficiency virus type I (HIV-1) usually leads to a rapid decline in the abundance of plasma virus. The effect of single drug therapy, however, is often only short-lived as the virus readily develops drug-resistant mutants. In this paper we provide analytic a
[Usefulness of cerebral biopsy in focal cerebral lesions in patients with human immunodeficiency virus infection]: Med Clin (Barc). 1996 Nov 30;107(19):738-41. Unique Identifier : AIDSLINE MED/97138954; Cordero E; Lara C; Canas E; Romero J; Trujillo F; Chinchon I; Pachon J; Departamento de Anatomia Patologica, Hospital Universitario Virgen del; Rocio, Sevilla.; Brain mass lesions (BML) occurred in 10% of patients infected by the human immunodeficiency virus (HIV), as expression of severe and sometimes treatable diseases. However, the management of them is not well established. We analyzed, retrospectively, 26 brain biopsies (22 estereotaxic) in patients with HIV infection an
[Effect of treatment with nucleoside analogues in subjects with primary genotypic resistance to zidovudine (letter)]: Med Clin (Barc). 1996 Nov 30;107(19):755. Unique Identifier : AIDSLINE MED/97138957; Leal M; Caruz A; Rey C; Lissen E
Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity.: Metabolism. 1997 Mar;46(3):303-5. Unique Identifier : AIDSLINE MED/97206981; Yarasheski KE; Zachwieja JJ; Horgan MM; Powderly WG; Santiago JV; Landt M; Division of Endocrinology, Washington University School of Medicine,; St Louis, MO 63110, USA.; The product of the obese gene (ob) is the protein leptin, which is synthesized in and secreted from adipocytes. Fasting serum leptin concentrations are closely related to body fat content and are higher in obese than in normal-weight individuals. Leptin may contribute to body weight regulation. Overproduction of lepti
Searching for answers on a clinical information system.: Methods Inf Med. 1995 Mar;34(1-2):79-84. Unique Identifier : AIDSLINE MED/97227853; Safran C; Center for Clinical Computing, Beth Israel Hospital, Harvard Medical; School, Boston, MA, USA.; We examined observational data on the use of a clinical computing system in an effort to develop an empirical model of clinicians information needs. Clinicians turn to information systems most often to review the results of diagnostic studies. After that, clinicians turn to information systems most often for communic
Subpopulations of T lymphocytes in the peripheral blood and lymph nodes of Indian kala-azar patients.: Med Microbiol Immunol (Berl). 1996 Nov;185(3):183-7. Unique Identifier : AIDSLINE MED/97160308; Ghosh MK; Ghosh AK; Addy M; Nandy A; Ghose AC; Department of Microbiology, Bose Institute, Calcutta, India.; Distribution of T cells in the peripheral blood and lymph nodes of Indian kala-azar (KA) patients was studied by using appropriate phenotypic markers for CD2+, CD4+ and CD8+ cells. Significant reduction in the CD2+, CD4+ cell numbers as well as CD4+/CD8+ cell ratio was noted in the peripheral blood of active KA cases.
Identification of a human endogenous LTR-like sequence using HIV-1 LTR specific primers.: Mol Cell Probes. 1996 Dec;10(6):443-51. Unique Identifier : AIDSLINE MED/97177566; Menin C; Indraccolo S; Montagna M; Corneo B; Bonaldi L; Leib-Mosch C; Chieco-Bianchi L; D'Andrea E; Istituto di Oncologia, University of Padova, Italy.; Using consensus primers derived from the LTR region of 15 HIV-1 isolates, a fragment of 583 bp was amplified from human DNA. Even though specificity was confirmed by Southern blot analysis with a conserved LTR oligonucleotide probe, no significant homologies were detected to either retroviral regions or human or non
Analysis of Epstein-Barr virus (EBV) type and variant in spontaneous lymphoblastoid cells and Hu-SCID mouse tumours.: Mol Cell Probes. 1996 Dec;10(6):453-61. Unique Identifier : AIDSLINE MED/97177567; Menin C; Ometto L; Veronesi A; Roncella S; Corneo B; Montagna M; Coppola V; Veronese ML; Indraccolo S; Amadori A; De Rossi A; Ferrarini M; Chieco-Bianchi L; D'Andrea E; Institute of Oncology, University of Padova, Italy.; Epstein-Barr virus (EBV) type and strain variations were examined using both lymphoblastoid cell lines (LCLs), spontaneously derived in vitro from peripheral blood mononuclear cells (PBMC) of 15 HIV-1-seropositive individuals; and SCID mouse tumours induced by inoculation of PBMC from 11 healthy human donors Hu-SCID t
A simplified semiquantitative determination of hepatitis C virus genome molecules by the end-point dilution method.: Mol Cell Probes. 1996 Dec;10(6):477-80. Unique Identifier : AIDSLINE MED/97177572; Bathelier C; Mercier G; Lucotte G; LCL Laboratory, Paris, France.; We describe a semiquantitative method to measure hepatitis C virus (HCV) viral particle numbers, by carrying out reverse-transcription polymerase chain reaction (RT-PCR) on serial dilutions of serum samples. The virus concentrations measured were 10(3)-10(6) viral particles ml-1 of serum. The method described is relat
Assessment of HIV risk outcomes in clinical trials for substance abuse pharmacology.: NIDA Res Monogr. 1996;162:46-8. Unique Identifier : AIDSLINE MED/97219510
Diagnosis of AIDS-related focal brain lesions: a decision-making analysis based on clinical and neuroradiologic characteristics combined with polymerase chain reaction assays in CSF.: Neurology. 1997 Mar;48(3):687-94. Unique Identifier : AIDSLINE MED/97217888; Antinori A; Ammassari A; De Luca A; Cingolani A; Murri R; Scoppettuolo G; Fortini M; Tartaglione T; Larocca LM; Zannoni G; Cattani P; Grillo R; Roselli R; Iacoangeli M; Scerrati M; Ortona L; Department of Infectious Diseases, Catholic University, Rome, Italy.; OBJECTIVE: To identify disease patterns in AIDS-related focal brain lesions (FBL) and to design a decision-making strategy for differential diagnosis. DESIGN: Prospective study. Probabilities of CNS disorders were calculated using Bayes theorem according to clinical variables (mass effect at CT or MRI, Toxoplasma ser
Sexually transmitted disease control in the armed forces, past and present.: Mil Med. 1997 Feb;162(2):87-91. Unique Identifier : AIDSLINE MED/97189935; Emerson LA; School of Medicine, University of Colorado Health Sciences Center,; Denver 80262, USA.; Sexually transmitted diseases (STDs) present a challenge for military medical personnel in their efforts to maintain a ready and healthy force. Many tactics have been used in military STD control programs. This paper is a review of the literature outlining some past strategies used in the
Electroretinographic and psychophysical findings during early and late stages of human immunodeficiency virus infection and cytomegalovirus retinitis.: Ophthalmology. 1997 Mar;104(3):445-53. Unique Identifier : AIDSLINE MED/97226427; Latkany PA; Holopigian K; Lorenzo-Latkany M; Seiple W; Department of Ophthalmology, NYU Medical Center, NY 10016, USA.; PURPOSE: The authors examined electrophysiologic and psychophysical measures of retinal function in patients infected with human immunodeficiency virus (HIV) at different stages of infection, including patients with cytomegalovirus retinitis CMVR). METHODS: All patients had complet
Anterior nongranulomatous uveitis after intravitreal HPMPC cidofovir) for the treatment of cytomegalovirus retinitis. Analysis and prevention [published erratum appears in Ophthalmology 1997 Jul;104(7):1063]: Ophthalmology. 1997 Mar;104(3):539-44. Unique Identifier : AIDSLINE MED/97226442; Chavez-de la Paz E; Arevalo JF; Kirsch LS; Munguia D; Rahhal FM; De Clercq E; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California San Diego, La Jolla 92093-0946, USA.; BACKGROUND AND OBJECTIVE: The authors characterize and analyze the incidence of a previously reported mild anterior nongranulomatous uveitis associated with intravitreal injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC), also termed cidofovir (Vistide, Gilead Sci
Cell lines containing and expressing the human herpesvirus 6A ts gene are protected from both H-ras and BPV-1 transformation.: Oncogene. 1997 Feb 27;14(8):937-43. Unique Identifier : AIDSLINE MED/97203275; Araujo JC; Doniger J; Stoppler H; Sadaie MR; Rosenthal LJ; Department of Microbiology and Immunology and Vincent T Lombardi; Cancer center, Georgetown University Medicial Center, Washington, DC; 20007, USA.; Human herpesvirus 6A (HHV-6A) strain U1102 was previously shown to contain a 1473 bp transformation suppressor gene (ts) (Araujo et al., 1995). Ts inhibited transformation of NIH3T3 cells by H-ras and transcription of the H-ras and human immunodeficiency type 1 (HIV-1) promoters in transient transfection experiments.
Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586), an extremely hydrophobic diprotic acid.: Pharm Res. 1996 Oct;13(10):1453-9. Unique Identifier : AIDSLINE MED/97055547; Venkatesh S; Li J; Xu Y; Vishnuvajjala R; Anderson BD; Department of Pharmaceutics and Pharmaceutical Chemistry, University; of Utah, Salt Lake City 84112, USA.; PURPOSE: The selection of cosalane (NSC 658586) by the National Cancer Institute for further development as a potential drug candidate for the treatment of AIDS led to the exploration of the solubility behavior of this extremely hydrophobic drug, which has an intrinsic solubility (S0 approaching 1 ng/ml. This study de
[Salmonella typhimurium cerebral abscess in a patient with HIV infection (letter)]: Presse Med. 1996 Dec 21;25(40):2052. Unique Identifier : AIDSLINE MED/97226627; Gueit I; Bani-Sadr F; Borsa-Lebas F; Caron F; Langlois O; Humbert G
[Renal involvement in HIV-1 infection]: Presse Med. 1997 Feb 1;26(2):91-5. Unique Identifier : AIDSLINE MED/97226588; Nochy D; Laboratoire d'Anatomopathologie, U 430, Hopital Broussais, Paris.
[Herpes simplex virus and varicella-zoster virus infections in HIV-infected patients]: Presse Med. 1997 Jan;26 Suppl 1:10-2. Unique Identifier : AIDSLINE MED/97226547; Leport C; Brun-Vezinet F; Service des-Maladies infectieuses et tropieales Centre Hospitalier; Bichat-Claude Bernard, Paris.
[Cytomegalovirus infections in HIV infection]: Presse Med. 1997 Jan;26 Suppl 1:13-5. Unique Identifier : AIDSLINE MED/97226548; Matheron S; Service des Maladies infectieuses et troplcates, Centre Hospitalier; Bichat-Claude Bernard, Paris.
[Human herpesvirus 8 infections]: Presse Med. 1997 Jan;26 Suppl 1:16-8. Unique Identifier : AIDSLINE MED/97226549; Agut H; Hopital de la Pitie-Salpetriere, Paris.
[New drugs for treatment of HIV infection receive europewide approval]: Pharm Unserer Zeit. 1996 Nov;25(6):334-5. Unique Identifier : AIDSLINE MED/97177894; Stipsits H; Bristol-Myers Squibb, Wien.
[Every year there are still 2000 more cases of HIV infection]: Pharm Unserer Zeit. 1996 Nov;25(6):339-40. Unique Identifier : AIDSLINE MED/97177895
Women's health. Sexually transmitted diseases.: Prim Care. 1997 Mar;24(1):179-93. Unique Identifier : AIDSLINE MED/97169322; Miller KE; Department of Family Medicine, Chattanooga Unit, University of; Tennessee College of Medicine, Chattanooga, Tennessee 37403, USA.; When providing health care for women, one of the more common problems facing the primary care physician is sexually transmitted diseases (STDs). It is important to be able to develop an accurate diagnosis and appropriate treatment plan for STDs to reduce the potential long-term sequelae of these infections. It is also
[Management of HIV infected patients. Report of recommendations]: Rev Pneumol Clin. 1996;52(5):277-360. Unique Identifier : AIDSLINE MED/97219536
Cytokine mRNA expression in lung tissue from toxic oil syndrome patients: a TH2 immunological mechanism.: Toxicology. 1997 Mar 14;118(1):61-70. Unique Identifier : AIDSLINE MED/97228594; del Pozo V; de Andres B; Gallardo S; Cardaba B; de Arruda-Chaves E; Cortegano MI; Jurado A; Palomino P; Oliva H; Aguilera B; Posada M; Lahoz C; Immunology Department, Fundacion Jimenez Diaz, Universidad Autonoma de; Madrid, Spain.; In 1981, an epidemic occurred in Spain , toxic oil syndrome (TOS), in people who consumed rapeseed oil denatured with 2% aniline, and it was one of the largest intoxication epidemics ever recorded. In 1989, a similar disease, eosinophilia-myalgia syndrome (EMS) was reported in the US
[Is the prevention of HIV/AIDS in Denmark effective? (editorial)]: Ugeskr Laeger. 1997 Mar 3;159(10):1406. Unique Identifier : AIDSLINE MED/97221167; Fouchard JR
[Fungi in feces, fungi in the intestines--therapeutic consequences?]: Versicherungsmedizin. 1996 Dec 1;48(6):215-7. Unique Identifier : AIDSLINE MED/97142638; Rosch W; Medizinischen Klinik am Krankenhaus Nordwest, Frankfurt am Main.; Yeast in stool specimen are due to transient or commensal growth in the GI tract. Only in immune deficient subjects candida albicans may grow invasively in squamous epithelium. In dermal or vaginal mycosis systemic therapy does not add benefit to local measures. Candida-induced diarrhea in hospitalized patients follow
FIV monitoring project [letter]: Vet Rec. 1996 Sep 7;139(10):243-4. Unique Identifier : AIDSLINE MED/97037707; Beatty J; Jarrett O
Detrimental effect of bovine leukemia virus (BLV) on the immunological state of cattle.: Vet Immunol Immunopathol. 1996 Nov;54(1-4):293-302. Unique Identifier : AIDSLINE MED/97142853; Trainin Z; Brenner J; Meirom R; Ungar-Waron H; Department of Immunology, Kimron Veterinary Institute, Israel.; Bovine leukemia virus (BLV) is a retrovirus which seems to affect both the humoral and the cellular immune response. Cows affected by enzootic bovine leukemia (EBL) showed a reduction of IgM-producing cells in the spleen and lymph nodes. Experimentally infected calves had lower levels of secretory IgM and a decrease i
Local TH1 and TH2 responses to parasitic infection in the intestine: regulation by IFN-gamma and IL-4.: Vet Immunol Immunopathol. 1996 Nov;54(1-4):337-44. Unique Identifier : AIDSLINE MED/97142857; Urban JF Jr; Fayer R; Sullivan C; Goldhill J; Shea-Donohue T; Madden K; Morris SC; Katona I; Gause W; Ruff M; Mansfield LS; Finkelman FD; Immunology and Disease Resistance Laboratory, Livestock and Poultry; Sciences Institute, Beltsville, MD 20705, USA.; Control of parasitic infections is dependent on the production of cytokines that activate mechanisms which limit invasion, reproduction or survival of the parasite. In contrast, conditions that induce inappropriate cytokine responses facilitate the spread of infection and ultimately exacerbate the level of disease. Me
Recognition of ovine lentivirus gag gene products by serum from infected sheep.: Vet Immunol Immunopathol. 1996 Dec;55(1-3):107-14. Unique Identifier : AIDSLINE MED/97166590; Kwang J; Rosati S; Yang S; Juste RA; de la Concha-Bermejillo A; USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933, USA.; In order to localize the immunodominant regions, 12 ovine lentivirus (OLV) gag-coding gene fragments were cloned and expressed in Escherichia coli and then tested in a Western blot WB) assay against a panel of sera collected from US and Italian OLV-infected sheep. The most immunoreactive regions were mapped to the ami
Phenotypic characterisation of intestinal lymphocytes in ovine paratuberculosis by immunohistochemistry.: Vet Immunol Immunopathol. 1996 Dec;55(1-3):175-87. Unique Identifier : AIDSLINE MED/97166596; Little D; Alzuherri HM; Clarke CJ; Department of Veterinary Pathology, University of Edinburgh,; Midlothian, UK. David.Little@ed.ac.uk; Characterisation of the T-cell subsets in intestinal lesions in sheep with paratuberculosis may contribute to our understanding of the pathogenesis of this disease. To determine the phenotype and distribution of lymphocytes in the normal sheep intestinal mucosa and in Mycobacterium avium subspecies paratuberculosis in
B-1a, B-1b and conventional B cell lymphoma from enzootic bovine leukosis.: Vet Immunol Immunopathol. 1996 Dec;55(1-3):63-72. Unique Identifier : AIDSLINE MED/97166586; Wu D; Takahashi K; Murakami K; Tani K; Koguchi A; Asahina M; Goryo M; Aida Y; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Morioka, Japan.; In order to characterize the phenotypes of tumor cells and to clarify from which B cell lineage the lymphomas were derived, ten cows with enzootic bovine leukosis were examined by means of immunohistologic staining and flow cytometry. The tumor cells expressed mainly major histocompatibility complex (MHC) class II+ 10
Decisions to have a baby by HIV-infected women.: West J Nurs Res. 1997 Feb;19(1):56-70. Unique Identifier : AIDSLINE MED/97181927; Sowell RL; Misener TR; College of Nursing, University of South Carolina, Columbia, USA.; As the epidemiologic picture of HIV changes to include increased numbers of women of childbearing age, particularly those of African American heritage and those from rural southern cultures, those who provide services to these women need to understand the processes used by HIV-infected women to make reproductive decis
Sexual transmission of HIV to women in industrialized countries.: World Health Stat Q. 1996;49(2):106-14. Unique Identifier : AIDSLINE MED/97202675; Hankins C; Montreal Regional Public Health Department, McGill University.; md77@musica.mcgill.ca; Biological differences between men and women help explain why the human immunodeficiency virus (HIV) is infecting increasing numbers of young girls and women in industrialized countries through heterosexual activity. As well, lack of economic and educational opportunities may not only lead women to resort to entering
Women and tuberculosis.: World Health Stat Q. 1996;49(2):115-9. Unique Identifier : AIDSLINE MED/97202676; Connolly M; Nunn P; Tuberculosis Research and Surveillance Unit, World Health; Organization, Geneva.; Tuberculosis is the leading infectious cause of death in women worldwide. The disease poses a major threat to women s health security. Population growth, the HIV epidemic, increasing poverty and rising levels of drug resistance will inevitably increase the burden of this disease in women. Women are at increased risk o
Women and health security.: World Health Stat Q. 1996;49(2):74-6. Unique Identifier : AIDSLINE MED/97202671; Hammad A el-B; World Health Organization, Geneva.
Women and AIDS in south and South-East Asia: the challenge and the response.: World Health Stat Q. 1996;49(2):94-105. Unique Identifier : AIDSLINE MED/97202674; Mboi N; South and South-East Asia are at the centre of the most aggressive advances of the AIDS epidemic today. The challenge this presents to the region is clear. While reported absolute numbers still lag behind the African region (11,160,900 in Africa; 3,081,235 in Asia) knowledgeable observers agree that the place of infec
[Therapy of chronic hepatitis B virus infection with the nucleoside analog lamivudine]: Z Gastroenterol. 1996 Dec;34(12):827-8. Unique Identifier : AIDSLINE MED/97170386; Jung MC; Zachoval R; Sackmann M; Medizinische Klinik und Poliklinik, Klinikum Grosshadern, Munchen.
Vaccination against feline leukaemia using a new feline herpesvirus type 1 vector.: Vaccine. 1996 Nov;14(16):1511-6. Unique Identifier : AIDSLINE MED/97166572; Willemse MJ; van Schooneveld SH; Chalmers WS; Sondermeijer PJ; Virological Research Department, Intervet International B.V., Boxmeer,; The Netherlands.; A recombinant feline herpesvirus type 1 (FHV-1) was constructed expressing the envelope glycoprotein gene from feline leukaemia virus (FeLV). The expression cassette containing the long terminal repeat promoter from Rous sarcoma virus was stably integrated at the locus downstream of the gC homologue in FHV-1. Oronasal
Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran.: Virus Res. 1996 Nov;45(1):1-13. Unique Identifier : AIDSLINE MED/97051511; Bahmani MK; Nowrouzian I; Nakaya T; Nakamura Y; Hagiwara K; Takahashi H; Rad MA; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; Borna disease virus (BDV) naturally infects horses and sheep and induces progressive poliomeningoencephalomyelitis. Here, BDV recombinant proteins of the first open reading frame (ORF-I; coding for p40 nucleoprotein) and the second ORF-II (coding for p24 polymerase cofactor) were immunoblotted with plasma derived from
[A complex approach to the diagnosis of HIV-1 infection: the use of the polymerase chain reaction as an alternative confirmatory test]: Zh Mikrobiol Epidemiol Immunobiol. 1996 Sep-Oct;(5):23-7. Unique Identifier : AIDSLINE MED/97108235; Eremin VF; Popov SA; Pyzhova NS; Kucherov II; Kuherer K; Oauli G; Rytik PG; Belorussian Research Institute of Epidemiology and Microbiology,; Minsk, Belarus.; The results of the three-year observation of female patient St. in whose blood antibodies to HIV disappeared in the course of time and the results of the laboratory study of the blood sera of children born of HIV-infected mothers are presented. In these patients correct diagnosis could be made only with the use of a c
[Suppression of the reproduction of the human immunodeficiency virus (HIV) with a cytokine-like antiviral factor]: Zh Mikrobiol Epidemiol Immunobiol. 1996 Sep-Oct;(5):27-9. Unique Identifier : AIDSLINE MED/97108236; Gribkova NV; Eremin VF; Votiakov VI; Shchelkanov MIu; Pashkova TA; Karamov EV; Cytokine-like antivirus factor, obtained from the culture fluid of chick embryo fibroblasts, was found to possess inhibitory activity with respect to HIV-1 (strains 1/Zmb and RF). The treatment of HIV-infected cell culture with cytokine-like factor was accompanied by a decrease in the cytopathic effect of the agent wi
Assessment of a neuropathic factor in HIV-1 associated impotence: penile electrodiagnosis.: Acta Physiol Hung. 1996;84(1):73-80. Unique Identifier : AIDSLINE MED/97146821; Siddiqi NA; Shaikh RN; Ali ST; Department of Surgery, Yamanashi Medical University, Japan.; The value of bulbocavernosus reflex latency verses nerve conduction velocity of the dorsal nerve of penis and penile brachial index was evaluated in 50 impotent individuals infected with the human immunodeficiency virus, type 1 (both symptomatic and asymptomatic) and in 50 aged matched HIV-1 sero-negative impotent men
Tuberculosis screening and anergy in a homeless population.: J Am Board Fam Pract. 1997 Jan-Feb;10(1):1-5. Unique Identifier : AIDSLINE MED/97171427; Morrow R; Fanta J; Kerlen S; Residency Program in Family Practice, St Joseph's Medical Center,; Yonkers, NY, USA.; BACKGROUND: Tuberculosis has again emerged as a growing public health concern in the United States . Among the homeless population, increased risk factors contribute to immunodeficiency, which can cause false-negative results on purified protein derivative (tuberculin) (PPD) skin testin
Left ventricular diastolic compression in acquired immunodeficiency syndrome with large, nonloculated pericardial effusion.: Am Heart J. 1997 Mar;133(3):383-4. Unique Identifier : AIDSLINE MED/97214433; D'Cruz IA; Calderon E; Kuri K; Shearin S; Cardiology Section, University of Tennessee, Memphis, USA.
The private insurance industry's tactics against suspected homosexuals: redlining based on occupation, residence and marital status.: Am J Law Med. 1996;22(4):477-502. Unique Identifier : AIDSLINE MED/97159327; Li KC; Barnard College, Columbia University, USA.
Initial screening for antituberculous drug resistance at an inpatient facility in Leon, Nicaragua.: Am J Trop Med Hyg. 1997 Jan;56(1):24-6. Unique Identifier : AIDSLINE MED/97217334; de la Hoz RE; Waycott S; Garcia D; Melendez R; Bia FJ; Department of Medicine, Yale University School of Medicine, New Haven,; Connecticut, USA.; Antituberculous (anti-TB) drug resistance has become a major tuberculosis control issue in the United States , where this situation has closely paralleled the current acquired immunodeficiency syndrome epidemic associated with human immunodeficiency virus type-1 (HIV-1) infections. In l
Correlation between human T cell lymphotropic virus type-1 and Strongyloides stercoralis infections and serum immunoglobulin E responses in residents of Okinawa, Japan.: Am J Trop Med Hyg. 1997 Jan;56(1):71-5. Unique Identifier : AIDSLINE MED/97217344; Hayashi J; Kishihara Y; Yoshimura E; Furusyo N; Yamaji K; Kawakami Y; Murakami H; Kashiwagi S; Department of General Medicine, Kyushu University Hospital, Fukuoka,; Japan.; To clarify the relationship between Strongyloides stercoralis, infection with human T cell lymphotropic virus type-1 (HTLV-1), and serum immunoglobulin E (IgE) levels, epidemiologic investigations of these two infections were conducted in inhabitants of Okinawa, a subtropical zone in Ja
Bacillary angiomatosis in an immunocompetent child.: Am J Dermatopathol. 1996 Dec;18(6):597-600. Unique Identifier : AIDSLINE MED/97144098; Smith KJ; Skelton HG; Tuur S; Larson PL; Angritt P; United States Army Medical Research Institute for Chemical Defense,; Rochester, New York, USA.; Bacillary angiomatosis (BA) is a pathological process characterized by prominent vascular proliferation secondary to organisms of the genus Rochalimaea. BA has been most commonly associated with HIV-1+ patients, but has also been reported rarely in other immune-suppressed patients and in a small group of patients with
Evidence and prevention of HIV-1 nucleocapsid protein adsorption onto fluorescence quartz cells.: Anal Biochem. 1997 Jan 1;244(1):183-5. Unique Identifier : AIDSLINE MED/97178537; Vuilleumier C; Maechling-Strasser C; Gerard D; Mely Y; Laboratorie de Biophysique, URA 491 du CNRS, Faculte de Pharmacie,; Universite Louis Pasteur, Strasbourg I, Illkirch, France.
[Syncitia inducing phenotype, zidovudine++ resistance and fast clinical progression in a child infected by HIV]: An Esp Pediatr. 1997 Jan;46(1):65-8. Unique Identifier : AIDSLINE MED/97202831; Mellado Pena MJ; Villota Arrieta J; Bernal Zamora A; Cilleruelo Ortega MJ; Garcia Lopez M; Barreiro Casal G; Perez Jurado ML; Martin Fontelos P; Servicio de Pediatria, Instituto de Salud Carlos III, Majadahonda,; Madrid.
The effect of megestrol acetate on anorexia, weight loss and cachexia in cancer and AIDS patients (review).: Anticancer Res. 1997 Jan-Feb;17(1B):657-62. Unique Identifier : AIDSLINE MED/97219297; Strang P; Department of Gynecologic Oncology, University Hospital, Uppsala,; Sweden.; Weight gain is a well-known side-effect of megestrol acetate (MA) treatment. This effect has been studied systematically in cancer and AIDS patients with involuntary weight loss, anorexia or manifest cachexia, situations in which weight gain is desirable. Significant, positive effects on weight gain and on certain qua
Evaluation of a brain-targeting zidovudine chemical delivery system in dogs.: Antimicrob Agents Chemother. 1997 Jan;41(1):122-8. Unique Identifier : AIDSLINE MED/97135228; Brewster ME; Anderson WR; Webb AI; Pablo LM; Meinsma D; Moreno D; Derendorf H; Bodor N; Pop E; Pharmos Corp., Alachua, Florida 32615, USA. Marcusbrew@aol.com; AIDS encephalopathy is an insidious complication of human immunodeficiency virus infection which is difficult to treat because of the poor uptake of many potentially useful antiretroviral drugs through the blood-brain barrier. A chemical delivery system (CDS) for zidovudine (
Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii.: Antimicrob Agents Chemother. 1997 Jan;41(1):162-8. Unique Identifier : AIDSLINE MED/97135234; Beach DH; Chen F; Cushion MT; Macomber RS; Krudy GA; Wyder MA; Kaneshiro ES; Department of Microbiology and Immunology, State University of New; York Health Science Center at Syracuse 13210, USA.; Several pathogenic fungi and protozoa are known to have sterols distinct from those of their mammalian hosts. Of particular interest as targets for drug development are the biosyntheses of the sterols of important parasites such as the kinetoplastid flagellates and the AIDS-associated opportunistic protist Pneumocysti
Single-dose pharmacokinetics of delavirdine mesylate and didanosine in patients with human immunodeficiency virus infection.: Antimicrob Agents Chemother. 1997 Jan;41(1):169-74. Unique Identifier : AIDSLINE MED/97135235; Morse GD; Fischl MA; Shelton MJ; Cox SR; Driver M; DeRemer M; Freimuth WW; Department of Pharmacy Practice, State University of New York at; Buffalo, USA.; Delavirdine is a nonnucleoside reverse transcriptase inhibitor with in vitro activity against human immunodeficiency virus type 1 (HIV-1) that is currently being evaluated in combination regimens with various nucleoside analogs, including didanosine.
Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia.: Antimicrob Agents Chemother. 1997 Jan;41(1):196-9. Unique Identifier : AIDSLINE MED/97135242; Nolte FS; Parkinson T; Falconer DJ; Dix S; Williams J; Gilmore C; Geller R; Wingard JR; Department of Pathology and Laboratory Medicine, Emory University; School of Medicine, Atlanta, Georgia, USA. fnolte@emory.edu; Infections with fluconazole-resistant Candida albicans isolate have rarely been described in clinical settings other than oropharyngeal candidiasis in patients with late-stage AIDS. We report on two patients with leukemia who developed fungemia caused by fluconazole-resistant C. albicans after receiving fluconazole pr
Therapeutic potential of anti-HIV immunotoxins.: Antiviral Res. 1996 Dec;33(1):1-9. Unique Identifier : AIDSLINE MED/97114028; Pincus SH; Department of Microbiology, Montana State University, Bozeman; 59717-3520, USA. umbsp@gemini.oscs.montana.edu; In vitro analyses have shown anti-HIV immunotoxins to be among the most effective AIDS antivirals tested. Because HIV has been continually selected by antibody, immunotoxins targeted to constant domains of viral antigens may not elicit drug-resistant mutants. A clinical trial with CD4-PE40, a possibly flawed immunotox
Inhibition of HIV replication by immunoliposomal antisense oligonucleotide.: Antiviral Res. 1996 Dec;33(1):11-20. Unique Identifier : AIDSLINE MED/97114029; Selvam MP; Buck SM; Blay RA; Mayner RE; Mied PA; Epstein JS; Center for Biologics, Evaluation and Research, US Food and Drug; Administration, Rockville, MD 20852, USA. Selvam@al.cher.fda.gov; The sequence-specific suppression of HIV-1 replication using CD4 monoclonal-antibody-targeted liposomes, containing Rev antisense phosphorothioate oligonucleotides is described. Liposomes were prepared by encapsulating the 20-mer antisense DNA sequence of the rev HIV-1 regulatory gene, in the form of a phosphorothioat
Inhibition of bovine immunodeficiency virus by anti-HIV-1 compounds in a cell culture-based assay.: Antiviral Res. 1996 Dec;33(1):21-31. Unique Identifier : AIDSLINE MED/97114030; Tobin GJ; Ennis WH; Clanton DJ; Gonda MA; Laboratory of Cell and Molecular Structure, SAIC Frederick, MD, USA.; tobin@mail.ncifcrf.gov; The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses. Although DNA sequences of these viruses have diverged considerably, the BIV genome organization, function of structural and regulatory genes, and replication cycle
Inhibition of human immunodeficiency virus replication by the sulfonated stilbene dye resobene.: Antiviral Res. 1996 Dec;33(1):41-53. Unique Identifier : AIDSLINE MED/97114032; Halliday SM; Lackman-Smith C; Bader JP; Rice WG; Clanton DJ; Zalkow LH; Buckheit RW Jr; Virology Research Group, Southern Research Institute, Frederick; Research Center, MD 21701, USA.; The anti-HIV sulfonated dye, resobene, was found to be a potent inhibitor of the attachment of HIV to target cells, the fusion of envelope- and CD4-expressing cells, and the cell-to-cell transmission of virus. Resobene inhibited the infection of phenotypically distinct, established human cell lines and fresh human per
Pulmonary manifestations in HIV seropositivity and malnutrition in Zimbabwe.: Arch Dis Child. 1997 Feb;76(2):124-8. Unique Identifier : AIDSLINE MED/97221255; Ikeogu MO; Wolf B; Mathe S; Department of Paediatrics, Mpilo Central Hospital, Bulawayo, Zimbabwe.; Over a 10 month period 184 children, aged 5 years or less, who died at home had their nutritional status and HIV serostatus established; necropsies were also carried out. The HIV antibody test was positive in 122/184 (66%). Of the HIV seropositive children Pneumocystis carinii pneumonia was present in 19 (16%),
A continuing survey of drug-resistant tuberculosis, New York City, April 1994.: Arch Intern Med. 1997 Mar 10;157(5):531-6. Unique Identifier : AIDSLINE MED/97219157; Fujiwara PI; Cook SV; Rutherford CM; Crawford JT; Glickman SE; Kreiswirth BN; Sachdev PS; Osahan SS; Ebrahimzadeh A; Frieden TR; New York City Department of Health, New York, USA.; BACKGROUND: A 1991 survey showed high levels of drug resistance among tuberculosis patients in New York, NY. As a result, the tuberculosis control program was strengthened, including expanded use of directly observed therapy and improved infection control. METHODS: We collected isolates from every patient in New York
Cutaneous infections due to Acanthamoeba in patients with acquired immunodeficiency syndrome.: Arch Intern Med. 1997 Mar 10;157(5):569-72. Unique Identifier : AIDSLINE MED/97219162; Chandrasekar PH; Nandi PS; Fairfax MR; Crane LR; Division of Infectious Diseases, Wayne State University School of; Medicine, Detroit, Mich, USA.; We report 2 cases of cutaneous Acanthamoeba infection in patients with acquired immunodeficiency syndrome. The disease, which manifests as subcutaneous nodules, mimics other more commonly encountered clinical entities. A high index of suspicion, familiarity with the clinical and histologic appearance of skin lesions,
Total lymphoid irradiation in rheumatoid arthritis. A ten-year followup.: Arthritis Rheum. 1997 Mar;40(3):426-9. Unique Identifier : AIDSLINE MED/97226219; Westhovens R; Verwilghen J; Dequeker J; University Hospitals, Katholieke Universiteit Leuven, Belgium.; OBJECTIVE: To report the findings of a 10-year followup of patients enrolled in a randomized trial of total lymphoid irradiation (TLI) versus chemotherapy for rheumatoid arthritis RA). METHODS: A retrospective analysis of the charts of 19 patients who had been included in a randomized trial comparing TLI and chemother
Juvenile rheumatoid arthritis-like polyarthritis in chromosome 22q11.2 deletion syndrome (DiGeorge anomalad/velocardiofacial syndrome/conotruncal anomaly face syndrome).: Arthritis Rheum. 1997 Mar;40(3):430-6. Unique Identifier : AIDSLINE MED/97226220; Sullivan KE; McDonald-McGinn DM; Driscoll DA; Zmijewski CM; Ellabban AS; Reed L; Emanuel BS; Zackai EH; Athreya BH; Keenan G; Division of Allergy, Immunology, and Infectious Diseases, Children's; Hospital of Philadelphia, PA 19104, USA.; OBJECTIVE: To investigate the association of polyarthritis and chromosome 22q11.2 deletions. METHODS: Eighty patients with chromosome 22q11.2 deletion syndrome followed up at The Children s Hospital of Philadelphia were examined for evidence of arthropathy or arthritis. Patients with chromosome 22q11.2 deletion syndro
Tenosynovial nodulosis in a patient infected with human T cell lymphotropic virus I.: Arthritis Rheum. 1997 Mar;40(3):578-82. Unique Identifier : AIDSLINE MED/97226239; Hasunuma T; Morimoto T; Tran TM; Muller-Ladner U; Aono H; Ogawa R; Gay S; Nishioka K; Institute of Medical Science, St. Marianna University, Kawasaki,; Japan.; We describe a 45-year-old man who presented with multiple nodules along the tendons of the scapular region, the elbows, wrists, forearms, thighs, and ankles. The patient was a carrier of human T cell lymphotropic virus I (HTLV-I), which was probably transmitted from his mother; his mother also had polyarthritis. Histo
Alcohol and cancer.: Alcohol Alcohol Suppl. 1994;2:453-5. Unique Identifier : AIDSLINE MED/97129911; Watson RR; Nixon P; Seitz HK; Maclennan R; Department of Family and Community Medicine, University of Arizona,; Tucson 85724, USA.
Synthesis and biological activity of acylated and telomerized peptides as potential HIV-fixation inhibitors.: Farmaco. 1996 Dec;51(12):767-73. Unique Identifier : AIDSLINE MED/97202714; Lacoux X; Barragan V; Dewynter G; Leydet A; Roque JP; Montero JL; Laboratoires de Chimie Biomoleculaire, Universite de Montpellier-II,; France.; In order to inhibit the gp 120-CD4 glycoprotein interaction, a key step of the HIV-infection, we have synthesized a series of N-acylated peptides containing sequences identified in both the viral and lymphocytic proteins, (SDFR, SDAR, RFDSAARFDS, DRADSRRS, PSKLNDRADSRRSLWD, ASTTTNYT). An hydrophobic moiety capryloyl,
HIV-associated cutaneous Kaposi's sarcoma--palliative local treatment by radiotherapy.: Acta Oncol. 1997;36(1):55-8. Unique Identifier : AIDSLINE MED/97227916; Saran FH; Adamietz IA; Thilmann C; Mose S; Bottcher HD; Department of Radiotherapy and Oncology, Johann Wolfgang; Goethe-University Frankfurt, Germany.; The increasing number of HIV-infected patients makes palliative treatment of HIV-associated Kaposi s sarcoma more common. We retrospectively evaluated a reduced fractionated radiotherapy with 20 Gy in respect to response rates and acute side-effects. From January 1992 to January 1995, 52 patients with HIV-associated K
Kyle.: Am J Hosp Palliat Care. 1997 Jan-Feb;14(1):8-9. Unique Identifier : AIDSLINE MED/97222871; Reiter G; Tufts University School of Medicine, Boston, Massachusetts, USA.
Transfer Factor in the Era of AIDS. Proceedings of the Xth International Symposium on Transfer Factor. Bologna, Italy, 22-24 June 1995.: Biotherapy. 1996;9(1-3):ix-x, 1-185. Unique Identifier : AIDSLINE MED/97146893
An attempt to inhibit the course of amyotrophic lateral sclerosis ALS) by suppressor factor.: Biotherapy. 1996;9(1-3):139-41. Unique Identifier : AIDSLINE MED/97146916; Nevsimal O; Pekarek J; Cech K; Neurological Clinic of the Medical Faculty, Charles's University,; Praha, Czech Republic.; Forty amyotrophic lateral sclerosis (ALS) patients were treated with suppressor factor. The therapy led to the normalization of the immunoregulatory index in approximately two thirds of the patients. The responder patients had a better clinical response, i.e. the degenerative process slowed down or it was even arreste
Influence of a DLE-extracted lymphocytic suppressor factor on CsA-induced immunosuppression.: Biotherapy. 1996;9(1-3):159-62. Unique Identifier : AIDSLINE MED/97146919; Rosso di San Secondo VE; Aniasi A; Piccolo G; Montecucchi PC; Sirchia G; Transplantation Immunology and Blood Transfusion Center,; University-Hospital Policlinico, Milano, Italy.; From dialyzable leucocyte extracts (DLE) we have purified a hydrophilic low-mol. wt. factor (about 1 kDa) which we have named lymphocytic suppressor factor (LSF) as it is able to suppress antigen- and mitogen-induced lymphocyte transformation and to prolong allograft survival in C57b/6N mice (H-2b) transplanted with f
Dialysable leucocyte extract (DLE) reduces lipopolysaccharide-induced tumour necrosis factor secretion in human leucocytes.: Biotherapy. 1996;9(1-3):163-70. Unique Identifier : AIDSLINE MED/97146920; Ojeda Ojeda M; Fernandez Ortega CB; Arana Rosainz MJ; Department of Cell Biology, Center for Biological Research, Havana,; Cuba.; Dialysable leucocyte extract (DLE), obtained from lysed leucocytes, provide clinical effectiveness in a broad spectrum of diseases. Tumour necrosis factor (TNF) is raised in AIDS patients leading to an increase in human immunodeficiency virus (HIV) replication in vitro [1,2], whereas progression to AIDS in asymptomati
AIDS and transfer factor: myths, certainties and realities.: Biotherapy. 1996;9(1-3):17-26. Unique Identifier : AIDSLINE MED/97146897; Viza D; Laboratoire d'Immunobiologie, URA 1294 CNRS, Faculte de Medecine des; Saints-Peres, Paris, France.; At the end of the 20th century, the triumph of biology is as indisputable as that of physics was at the end of the 19th century, and so is the might of the inductive thought. Virtually all diseases have been seemingly conquered and HIV, the cause of AIDS, has been fully described ten years after the onset of the epide
Rationale and clinical results of using leucocyte-derived immunosupportive therapies in HIV disease.: Biotherapy. 1996;9(1-3):27-31. Unique Identifier : AIDSLINE MED/97146898; Gottlieb AA; Sizemore RC; Gottlieb MS; Kern CH; Tulane University, New Orleans, LA 70112, USA.; Leucocyte dialysates contain a number of substances which exert important effects on human cell-mediated immunity. In this report, we describe several properties of a designated subfraction, IMREGR-1, which is obtained by a second dialysis against a membrane having a 3500 m.w. cutoff. These include the ability to augm
Inhibition of in vitro HIV infection by dialysable leucocyte extracts.: Biotherapy. 1996;9(1-3):33-40. Unique Identifier : AIDSLINE MED/97146899; Fernandez-Ortega C; Dubed M; Ruibal O; Vilarrubia OL; Menendez de San Pedro JC; Navea L; Ojeda M; Arana MJ; Department of Cellular Biology, Center for Biological Research and; Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Dialysable Leucocyte Extract (DLE) is a low molecular weight dialysable material of disrupted peripheral human leucocytes with widespread effects on the immune system. We described the in vitro anti-HIV activity of DLE as well as its three chromatographic fractions (Fa, Fb and Fc). To determine the levels of inhibitio
Preliminary observations using HIV-specific transfer factor in AIDS.: Biotherapy. 1996;9(1-3):41-7. Unique Identifier : AIDSLINE MED/97146900; Pizza G; Chiodo F; Colangeli V; Gritti F; Raise E; Fudenberg HH; De Vinci C; Viza D; Immunodiagnosis and Immunotherapy Unit, Ospedale S. Orsola-Malpighi,; Bologna, Italy.; Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally with HIV-1-specific transfer factor (TF) for periods varying from 60 to 1870 days. All patients were receiving antiviral treatments in association with TF. The number of lymphocytes, CD4 and CD8 subsets were followed and sh
Preliminary results in HIV-1-infected patients treated with transfer factor (TF) and zidovudine (ZDV).: Biotherapy. 1996;9(1-3):49-54. Unique Identifier : AIDSLINE MED/97146901; Raise E; Guerra L; Viza D; Pizza G; De Vinci C; Schiattone ML; Rocaccio L; Cicognani M; Gritti F; Dept. of Infectious Diseases, Maggiore Hospital, Bologna, Italy.; The efficiency of HIV-1 specific transfer factor (TF) administration, combined with Zidovudine (ZDV), in asymptomatic persistent generalised lymphadenopaty, or AIDS related complex ARC) patients was evaluated. Twenty patients were randomly assigned to receive only ZDV (1st group) or ZDV together with HIV-1-specific TF
Profiles of cytokine production in recipients of transfer factors.: Biotherapy. 1996;9(1-3):55-9. Unique Identifier : AIDSLINE MED/97146902; Alvarez-Thull L; Kirkpatrick CH; Innovative Therapeutics, Inc., Denver, CO, USA.; Transfer factors (TF) are proteins that transfer the ability to express cell-mediated immunity from immune donors to non-immune recipients. The mechanisms of these effects have not been defined. The experiments described in this report were undertaken to test the hypothesis that a mechanism through which the beneficia
Orally administered HSV-specific transfer factor (TF) prevents genital or labial herpes relapses.: Biotherapy. 1996;9(1-3):67-72. Unique Identifier : AIDSLINE MED/97146904; Pizza G; Viza D; De Vinci C; Palareti A; Cuzzocrea D; Fornarola V; Baricordi R; Immunodiagnosis and Immunotherapy Unit, 1st-Division of Urology, S.; Orsola-Malpighi Hospital, Bologna, Italy.; Forty-four patients suffering from genital (22) and labial (22) herpes were orally treated with HSV-1/2-specific transfer factor TF). TF was obtained by in vitro replication of a HSV-1/2-specific bovine dialysable lymphocyte extract. Treatment was administered bi-weekly the first 2 weeks, and then weekly for 6 months,
The use of transfer factors in chronic fatigue syndrome: prospects and problems.: Biotherapy. 1996;9(1-3):77-9. Unique Identifier : AIDSLINE MED/97146906; Levine PH; Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD,; USA.; Chronic fatigue syndrome (CFS) is a heterogeneous disorder characterized by severe prolonged unexplained fatigue and a variety of associated symptoms such as arthralgias, myalgias, cognitive dysfunction, and severe sleep disturbances. Many patients initially present with an acute onset of apparent infectious origin wi
The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections.: Biotherapy. 1996;9(1-3):91-5. Unique Identifier : AIDSLINE MED/97146909; Hana I; Vrubel J; Pekarek J; Cech K; Dept. of Immunology, Institute for Clinical and Experimental Medicine,; Prague, Czechia.; A group of 222 patients suffering from cellular immunodeficiency CID), frequently combined with chronic fatigue syndrome (CFS) and/or chronic viral infections by Epstein-Barr virus (EBV) and/or cytomegalovirus ( CMV ), were imm
Activity-dependent neurotrophic factor (ADNF). An extracellular neuroprotective chaperonin?: J Mol Neurosci. 1996 Winter;7(4):235-44. Unique Identifier : AIDSLINE MED/97123698; Gozes I; Brenneman DE; Department of Clinical Biochemistry, Sackler School of Medicine, Tel; Aviv University, Israel.; To understand and intervene in neuronal cell death, intensive investigations have been directed at the discovery of intracellular and extracellular factors that provide natural neuroprotection. This goal has fundamental importance for both rational strategies for the treatment of neurodegenerative diseases and also th
Leishmania/HIV co-infection. Epidemiological analysis of 692 retrospective cases.: Wkly Epidemiol Rec. 1997 Feb 21;72(8):49-54. Unique Identifier : AIDSLINE MED/97208493
Is HTLV-1 status another antenatal screening test that we need?: Br J Obstet Gynaecol. 1997 Feb;104(2):258-60. Unique Identifier : AIDSLINE MED/97223266; Otigbah C; Kelly A; Aitken C; Norman J; Jeffries D; Erskine KJ; Homerton Hospital, London.; Human T-lymphocytic virus type 1 (HTLV-1) carriage is associated with a 2% to 5% lifetime risk of developing a severe, if not fatal, disease. In our Inner London antenatal population, we found that the carrier rate was 0.3%. The antenatal transmission rate is known to be very low, but if the infant is breastfed the tr
Blood transfusion in obstetrics and gynaecology [see comments]: Br J Obstet Gynaecol. 1997 Mar;104(3):278-84. Unique Identifier : AIDSLINE MED/97226253; Ekeroma AJ; Ansari A; Stirrat GM; Department of Obstetrics and Gynaecology, University of Bristol, St; Michael's Hospital.
Hepatitis C virus in saliva of haemophiliac patients attending an oral surgery unit.: Br J Oral Maxillofac Surg. 1996 Apr;34(2):162-5. Unique Identifier : AIDSLINE MED/97014455; Roy KM; Bagg J; Follett EA; Brewer A; Lowe GD; Department of Oral Sciences, University of Glasgow Dental School,; Glasgow, UK.; This study determined the frequency with which hepatitis C virus HCV) could be detected in the saliva of 21 HCV-seropositive haemophiliac patients attending an Oral Surgery Unit. All sera were positive for HCV RNA by the polymerase chain reaction (PCR). Six of the patients were also HIV antibody positive. Saliva was c
Antisense therapy.: Curr Opin Oncol. 1996 Nov;8(6):509-15. Unique Identifier : AIDSLINE MED/97126556; Narayanan R; Akhtar S; Roche Research Center, Hoffmann-La Roche, Inc., Nutley, NJ 07110, USA.; The sequence specificity of the antisense technique makes it an attractive basis for novel molecular therapeutics. Inhibition of gene expression by antisense in cell culture models has provided a strong rationale for identification and validation of disease targets. Analogues modified from normal phosphodiester oligod
Listeriosis.: Clin Infect Dis. 1997 Jan;24(1):1-9; quiz 10-1. Unique Identifier : AIDSLINE MED/97148115; Lorber B; Section of Infectious Diseases, Temple University School of Medicine; and Hospital, Philadelphia, Pennsylvania, USA.
Infection due to fluconazole-resistant Candida in patients with AIDS: prevalence and microbiology.: Clin Infect Dis. 1997 Jan;24(1):28-34. Unique Identifier : AIDSLINE MED/97148120; Maenza JR; Merz WG; Romagnoli MJ; Keruly JC; Moore RD; Gallant JE; Department of Pathology, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; A cross-sectional study was conducted to assess the prevalence and microbiology of oral infection due to fluconazole-resistant Candida in patients with AIDS. Oral swab specimens for fungal cultures were obtained from 100 consecutive outpatients with CD4 lymphocyte counts of
Redefining AIDS: towards a modification of the current AIDS case definition.: Clin Infect Dis. 1997 Jan;24(1):64-74. Unique Identifier : AIDSLINE MED/97148133; Albrecht H; Medizinische Klinik, Universitaetskrankenhaus Eppendorf, Hamburg,; Germany.; AIDS is defined by the occurrence of an opportunistic infection or tumor considered indicative of advanced infection with human immunodeficiency virus (HIV). Even though recent modifications have improved the widely used AIDS case definition issued by the World Health Organization and
Azithromycin-related ototoxicity in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Jan;24(1):76-7. Unique Identifier : AIDSLINE MED/97148134; Tseng AL; Dolovich L; Salit IE; Immunodeficiency Clinic, Toronto Hospital-Toronto General Division,; Ontario, Canada.
Testicular abscess due to Streptococcus pneumoniae in an infant with human immunodeficiency virus infection.: Clin Infect Dis. 1997 Jan;24(1):84-5. Unique Identifier : AIDSLINE MED/97148140; Dobroszycki J; Abadi J; Lambert G; Beenhouwer DO; Truong TH; Wiznia AA; Department of Pediatrics, Bronx Lebanon Hospital Center, New York; 10457, USA.
Emergence of increased resistance to quinupristin/dalfopristin during therapy for Enterococcus faecium bacteremia.: Clin Infect Dis. 1997 Jan;24(1):90-1. Unique Identifier : AIDSLINE MED/97148127; Chow JW; Donahedian SM; Zervos MJ; Division of Infectious Diseases, Wayne State University School of; Medicine, Detroit, Michigan 48201-2021, USA.
Strongyloides stercoralis infection in patients infected with human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1997 Jan;24(1):95. Unique Identifier : AIDSLINE MED/97148131; Guerin JM; Leibinger F; Mofredj A
[Alkaline encrusted cystitis secondary to Proteus mirabilis infection in a HIV infected patient]: An Med Interna. 1997 Jan;14(1):33-4. Unique Identifier : AIDSLINE MED/97215656; Cano Sanchez A; Sanchez Monton T; Gil Rueda B; Tello C; Berna JD; Gonzalez-Sicilia L; Servicio de Medicina Interna, Hospital General Universitario, Murcia.; We described for the first time an alkaline encrusting cystitis in a patient with the acquired immune deficiency. This is an entity characterized by severe dysuria and long standing urinary frequency, alkaline urine and radiographically visible calcification of the urinary bladder. It has been observed in patients wit
Harvard report on cancer prevention. Causes of human cancer. Infectious agents.: Cancer Causes Control. 1996 Nov;7 Suppl 1:S25-7. Unique Identifier : AIDSLINE MED/97086900
The detection of B-form/A-form junction in a deoxyribonucleotide duplex.: Biophys J. 1996 Dec;71(6):3344-9. Unique Identifier : AIDSLINE MED/97123356; Ivanov VI; Minchenkova LE; Burckhardt G; Birch-Hirschfeld E; Fritzsche H; Zimmer C; W. A. Engelhardt Institute of Molecular Biology, Russian Academy of; Sciences, Moscow, Russia.; The transition of the 14-meric deoxyoligonucleotide duplex d-(ACCCCCTTTTTTTG).d-(CAAAAAAAGGGGGT) from the B- to the A-conformation in water/trifluorethanol (TFE) solution was studied with the use of circular dichroism. An increase in the fraction of TFE induces a two-step B-A transition. In the first step, up to 73% T
Will killing the last HIV1 particle cure AIDS patients? II: Second Part. Decrease of viral load and of T-suppressor cells, and increase of the cytotoxic cells, without effect on CD4, after the use of 10 virostatics applied in 3 or 4 drug combinations of different sequences. The time for CD4 immunotherapy? [editorial]: Biomed Pharmacother. 1996;50(10):473-9. Unique Identifier : AIDSLINE MED/97226780; Mathe G; Colasante U; Morette C; Hallard M; Blanquet D; We reported in the first part of this editorial and in an article AIDS therapy with five HIV1 virostatics applied in two then three, or initially three, or initially four agent combinations, given in 3 week sequences differing from each other due to drug rotation, the contrast between: a) the decrease of viral load, p
Contribution of cohort studies in understanding HIV pathogenesis: introduction of the GRIV cohort and preliminary results.: Biomed Pharmacother. 1996;50(10):480-7. Unique Identifier : AIDSLINE MED/97226781; Hendel H; Cho YY; Gauthier N; Rappaport J; Schachter F; Zagury JF; Laboratoire de Physiologie Cellulaire, Universite Pierre et Marie; Curie, Paris.; In the present paper we review studies performed on HIV-infected patients cohorts in order to understand AIDS disease development. The interplay between diverse factors such as the HIV envelope proteins, cellular co-receptors, the immune response with chemokines and cytokines production define the viral tropism, cytop
Antigen/antibody content of circulating immune complexes in HIV-infected patients.: Biomed Pharmacother. 1996;50(10):488-93. Unique Identifier : AIDSLINE MED/97226782; Stanojevic M; Zerjav S; Jevtovic D; Markovic L; Institute of Infectious and Tropical Diseases CCS, Belgrade,; Yugoslavia.; Dual infection with HIV and hepatitis B virus (HBV) is not an uncommon feature. Immunity impairment due to HIV infection can be the cause of a higher rate of HBV replication with less intensive liver damage and less effective immune response to HBV. Many HIV-infected patients have an elevated level of circulating immu
Lymphoproliferative response to synthetic V3 loop P18 peptide and HIV-1 envelope glycoprotein among individuals immunized with gp160 candidate vaccines.: Biomed Pharmacother. 1996;50(10):494-9. Unique Identifier : AIDSLINE MED/97226783; Moukrim Z; Cho YY; Mbika JP; Achour A; Universite Pierre et Marie Curie, Paris, France.; Because T-cell responses are critical for defense against viral infections, the synthetic P18 peptide (RIQRGPGRAFVTIGK) and active component of gp160 protein has previously been shown to induce cytotoxic and helper T-lymphocyte responses. In order to further define the T-helper cells, responses which are known to play
Surgical indications for HIV-infected patients.: Biomed Pharmacother. 1996;50(10):500. Unique Identifier : AIDSLINE MED/97226784; Eriguchi M; Takeda Y; Fujii Y; Department of Surgery, University of Tokyo, Japan.; We proposed surgical indications for major operations on HIV-infected patients. According to our criteria, major surgery could be performed for HIV-infected patients as long as the surgical approach is preferred and surgery is not likely to exacerbate the subject s quality of life during the course of the disease.
Isolation and virological characterization of HIV-1 in Cuba. Relationship with the clinical status of the patients.: Biomed Pharmacother. 1996;50(10):501-4. Unique Identifier : AIDSLINE MED/97226785; Lobaina L; Noa E; Dubed M; Navea L; Vilarrubia OL; Diaz H; Department of Microbiology, AIDS Research Laboratory, Havana, Cuba.; The objective of this paper is the isolation and biological characterization of HIV-1 from patients at different clinical status of the disease. Clinical, epidemiological and virological aspects of 54 infected people were studied. Isolate HIV-1 strains were characterized and classified in relation with replication kin
Purine metabolism in HIV-1 virus-infected T lymphocyte population.: Biomed Pharmacother. 1996;50(10):505-9. Unique Identifier : AIDSLINE MED/97226786; Carlucci F; Tabucchi A; Perrett D; Pizzichini M; Rosi F; Pagani R; Marinello E; Istituto di Biochimica e di Enzimologia, Siena, Italy.; Purine nucleotide metabolism has been studied in T-lymphocyte population in healthy subjects and in AIDS bearing patients. Nucleotide content was determined by HPLC. The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a T cell suspension. The
Lymphangiographic study of pelvic adenopathy regression in a phase II trial of methyl-hydroxy-ellipticine in HIV1-AIDS complex [letter]: Biomed Pharmacother. 1996;50(10):510-1. Unique Identifier : AIDSLINE MED/97226787; Mathe G; Hallard M; Pontiggia P
Effect of left atrial size on recurrence of atrial fibrillation after electrical cardioversion: atrial dimension versus volume.: Am J Card Imaging. 1996 Oct;10(4):261-5. Unique Identifier : AIDSLINE MED/97164587; Volgman AS; Soble JS; Neumann A; Mukhtar KN; Iftikhar F; Vallesteros A; Liebson PR; Rush Heart Institute, Rush-Presbyterian-St. Luke's Medical Center,; Chicago, IL 60612, USA.; There are conflicting reports on the relationship between left atrial dimension (LAD) determined by echo-cardiography and the incidence of atrial fibrillation (AF) recurrence after electrical cardioversion (EC). We hypothesized that left atrial volume (LAV) by echocardiography might better differentiate patients who w
Beta-2-microglobulin, neopterin and monocyte Fc gamma receptors in opportunistic infections of HIV-positive patients.: Br J Biomed Sci. 1996 Dec;53(4):263-9. Unique Identifier : AIDSLINE MED/97222084; Dunne J; Feighery C; Whelan A; Immunology Laboratory, St. Jame's Hospital, Dublin, Ireland.; The aim of this study was to examine serum and cellular markers of immune activation in HIV-positive (HIV+) patients with and without current opportunistic infections. Fc gamma receptor (Fc gamma R) expression on monocytes, serum neopterin and beta-2-microglobulin were studied. Thirty HIV+ patients (grouped according
Free energy mapping of class I MHC molecules and structural determination of bound peptides.: Protein Sci. 1996 Jul;5(7):1272-81. Unique Identifier : AIDSLINE MED/96416254; Sezerman U; Vajda S; DeLisi C; Department of Biomedical Engineering, Boston University College of; Engineering, Massachusetts 02218, USA.; Free energy maps of the binding site are constructed for class I major histocompatibility complex (MHC) proteins, by rotating and translating amino acid probes along the cleft, and performing a side-chain conformational search at each position. The free energy maps are used to determine favorable residue positions tha
Autologous bone marrow transplantation in relapsed HIV-related non-Hodgkin's lymphoma.: Bone Marrow Transplant. 1996 Dec;18(6):1195-7. Unique Identifier : AIDSLINE MED/97126481; Gabarre J; Leblond V; Sutton L; Azar N; Jouan M; Boccaccio C; Gonzalez H; Charlotte F; Gentilini M; Binet JL; Services d'Hematologie, Hopital Pitie-Salpetriere, Paris, France.; There are few reports of salvage chemotherapy for HIV-related non-Hodgkin s lymphoma (NHL). We report a relapsed HIV-related high-grade NHL which was treated successfully with ESHAP chemotherapy followed by high-dose chemotherapy and autologous bone marrow transplantation (ABMT). A
Surveillance of HIV and AIDS in 1996.: Commun Dis Rep CDR Wkly. 1997 Jan 24;7(4):17. Unique Identifier : AIDSLINE MED/97181703
Transmission of HIV from an infected surgeon to a patient in France.: Commun Dis Rep CDR Wkly. 1997 Jan 24;7(4):17. Unique Identifier : AIDSLINE MED/97181702
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Jan 24;7(4):29-32. Unique Identifier : AIDSLINE MED/97181704
New York court rules on limits of AIDS disability claims.: J Law Med Ethics. 1996 Fall;24(3):270-1. Unique Identifier : AIDSLINE MED/97222969; Michael A
Eleventh Circuit denies claim under PDA.: J Law Med Ethics. 1996 Fall;24(3):272-3. Unique Identifier : AIDSLINE MED/97222972
The rising prevalence of HIV-1 infection in patients attending an inner city accident and emergency department.: J Accid Emerg Med. 1996 Nov;13(6):424-5. Unique Identifier : AIDSLINE MED/97103434; Poznansky MC; Walters J; Cruikshank A; Pollock R; Dendrowskyj P; Lewis K; Parry JV; Fothergill J; Weber J; Department of Accident and Emergency Medicine, St Mary's Hospital,; London.; The recently published findings of the unlinked anonymous HIV prevalence study in England and Wales showed unchanging HIV prevalence in groups such as homo/bisexual men, and declining rates in non-injecting heterosexual men attending genitourinary medicine clinics. However, this multicentre study did detect a signific
Understanding the role of Th1/Th2 cells in infection.: Trends Microbiol. 1996 Dec;4(12):470-3. Unique Identifier : AIDSLINE MED/97158129; Romagnani S; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy.
BaEV is a relic from an ancient retrovirus that crossed species barriers [letter; comment]: Trends Microbiol. 1996 Dec;4(12):478. Unique Identifier : AIDSLINE MED/97158132; Vandamme AM
Pararetro- and retrovirus RNA: splicing and the control of nuclear export.: Trends Microbiol. 1996 Dec;4(12):480-5. Unique Identifier : AIDSLINE MED/97158133; Kiss-Laszlo Z; Hohn T; Laboratoire de Biologie Moleculaire Eucaryote, CNRS, Toulouse, France.; Splicing and nuclear export of RNA are obligatory steps in gene expression by eukaryotic cells. Not only have novel splicing events been identified during the replication cycle of retro- and pararetroviruses, but the resulting combination of spliced and unspliced products requires specialized mechanisms for nuclear ex
Psoriasis and bacterial superantigens--formal or causal correlation?: Trends Microbiol. 1996 Dec;4(12):485-9. Unique Identifier : AIDSLINE MED/97158134; Boehncke WH; Dept of Dermatology, Frankfurt University School of Medicine, Germany.; Superantigens have recently been identified as candidates for triggering crucial events in the development of psoriasis. Seemingly contradictory observations may complement each other when discussed in the context of the concept of an effector cell cascade initiated by bacterial superantigens that eventually brings ab
CD4 and total lymphocyte count [letter]: QJM. 1997 Feb;90(2):155. Unique Identifier : AIDSLINE MED/97221763; Brettle RP
Kaposi's Sarcoma of the intestine in an HIV-negative patient associated with immunosuppressive therapy for severe aplastic anemia [letter]: J Pediatr Hematol Oncol. 1997 Jan-Feb;19(1):86-8. Unique Identifier : AIDSLINE MED/97218065; Abhyankar SH; Burns RG; Godder KT; Pati AR; Henslee-Downey PJ
Partners in AIDS Prevention: a U.S./Japan collaboration.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S1-80. Unique Identifier : AIDSLINE MED/97223925
An overview of HIV prevention in the United States.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S13-6. Unique Identifier : AIDSLINE MED/97223927; Coates TJ; Feldman MD; UCSF AIDS Research Institute, University of California, San Francisco; 94105, USA.; Despite recent promising results with protease inhibitors and combinations of drugs in treating HIV-infected persons, a cure or vaccine for AIDS is unlikely within the next several years. Therefore, prevention remains the most realistic strategy for dealing with the
AIDS policy in Japan: integration within structured paternalism.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S17-21. Unique Identifier : AIDSLINE MED/97223928; Yonemoto S; Program on Life Science and Society, Mitsubishi Kasei Institute of; Life Sciences, Tokyo, Japan.; Structured paternalism consists of the setting of public policy by centralized authority without the benefit of surveillance and research to guide it. It is a concept deeply embedded in Japanese society, based on the belief that the central government is the highest authority. It strongly affects decision-making regar
Science, politics, and AIDS prevention policy.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S22-9. Unique Identifier : AIDSLINE MED/97223929; Bayer R; School of Public Health, Columbia University, New York, New York; 10032, USA.; The relationships among science, politics, and health care policy have changed dramatically over the years since AIDS was first diagnosed in the United States . Initially politics was viewed as inimical to prevention; now it is viewed as central. The challenge is to ensure that policies
Descriptive epidemiology of HIV/AIDS in Japan, 1985-1994.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S3-12. Unique Identifier : AIDSLINE MED/97223926; Kihara M; Ichikawa S; Kihara M; Yamasaki S; Department of Epidemiology, Kanagawa Cancer Center Research Institute,; Yokohama, Japan.; The HIV epidemic in Japan appears to be following a unique course, with no predominance of homosexual contact over heterosexual contact in reported cases and relatively little transmission by injection drug users and commercial sex workers. Infection rates are still low compared wit
HIV and the primary care physician in Japan.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S30-4. Unique Identifier : AIDSLINE MED/97223930; Asai A; Department of General Medicine and Clinical Epidemiology, Kyoto; University School of Medicine, Japan.; Primary care physicians in Japan must provide comprehensive medical care and counseling for persons both infected with and at risk for HIV/AIDS. Despite existing activities and education programs, HIV case numbers continue to rise in Japan, and only a limited number of hospitals and
HIV/AIDS care at Tokyo Metropolitan Komagome Hospital.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S35-7. Unique Identifier : AIDSLINE MED/97223931; Negishi M; Tokyo Metropolitan Komagome Hospital, Japan.; The mission of the Tokyo Metropolitan Komagome Hospital is to build a comprehensive system to provide treatment for people infected with HIV. It aims not only to provide HIV clinical care medical and skilled nursing) but also to build psychological and social support systems for persons with HIV/AIDS. It is also worki
AIDS epidemic in San Francisco among men who report sex with men: successes and challenges of HIV prevention.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S38-46. Unique Identifier : AIDSLINE MED/97223932; Katz MH; San Francisco Department of Public Health, and the University of; California, San Francisco School of Medicine, 94102-6033, USA.; San Francisco s gay male community has been hit harder by the HIV/AIDS epidemic than any other community in the world. By 1995, 20,530 of the estimated 58,000 gay men had been diagnosed with AIDS. However, the epidemic has also been more effectively contained within San Francisco than anywhere else, as evidenced by ra
Gay men and HIV in Japan.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S47-50. Unique Identifier : AIDSLINE MED/97223933; Sawazaki Y; Japanese Foundation for AIDS Prevention, Tokyo.; Unique aspects of Japanese culture have shaped the response of homosexual men to HIV infection in Japan. Japan is a relatively homogeneous society that has, by and large, felt invulnerable to AIDS, viewing it primarily as a Western phenomenon. This attitude has been common in the gay community as well and has resulted
HIV prevention and community-based organizations in Japan.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S51-7. Unique Identifier : AIDSLINE MED/97223934; Ikegami C; Place Tokyo, Japan.; The first AIDS-related community-based organizations (CBOs) in Japan emerged in the 1980s for persons who contracted HIV through infected blood products. Since then, more than 50 CBOs have been established to reach out to all HIV-infected persons. Most are centered in Tokyo. CBO act
International HIV and AIDS prevention: Japan/United States collaboration.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S58-67. Unique Identifier : AIDSLINE MED/97223935; Umenai T; Narula M; Onuki D; Yamamoto T; Igari T; Department of Health Policy and Planning, School of International; Health, University of Tokyo, Japan.; As the epicenter of the HIV/AIDS pandemic shifts from Africa to Asia, Japan is becoming ever more aware of the importance of containing and preventing spread of the virus. International collaboration, particularly with the United States , is a logical
Japan/United States collaboration in international HIV prevention and care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14 Suppl 2:S68-80. Unique Identifier : AIDSLINE MED/97223936; Brown T; Gayle J; Morita K; Brenden N; East-West Center, Honolulu, Hawaii 96848, USA.; At a time when funds for international HIV/AIDS prevention and care appear to be declining, coordinated efforts that maximize resource impact are critical. As leaders in the international community and the world s two largest donors of development assistance, it is appropriate for the Unit
Oral lesions as markers of severe immunosuppression in HIV-infected homosexual men and injection drug users.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Sep;82(3):276-83. Unique Identifier : AIDSLINE MED/97039273; Begg MD; Panageas KS; Mitchell-Lewis D; Bucklan RS; Phelan JA; Lamster IB; Center for Oral HIV Studies, Columbia University School of Dental and; Oral Surgery, New York, N.Y. USA. begg@biostat.columbia.edu; OBJECTIVES: We examined the diagnostic utility of the presence of oral lesions, individually and in combination, in identifying severe immunosuppression, defined as CD4 cell count under 200. STUDY DESIGN: Data were collected on 82 HIV-seropositive homosexual men and 82 HIV-seropositive injection drug users who volunte
Relationship of cytomegalovirus to salivary gland dysfunction in HIV-infected patients.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Mar;83(3):334-9. Unique Identifier : AIDSLINE MED/97237740; Greenberg MS; Glick M; Nghiem L; Stewart JC; Hodinka R; Dubin G; Department of Oral Medicine, University of Pennsylvania School of; Dental Medicine, Philadelpia, USA.; In a previous retrospective study of HIV-infected patients we detected a relationship between xerostomia and the presence of cytomegalovirus in saliva. This prospective study compares 13 patients with HIV and a complaint of xerostomia and low salivary flow rates with a control grou
Liposomal daunorubicin marketed for HIV-related Kaposi's sarcoma [news]: Am J Health Syst Pharm. 1996 Jul 1;53(13):1500, 1505. Unique Identifier : AIDSLINE MED/96405129
Criteria for use of rifabutin in adult patients with human immunodeficiency virus (HIV)-associated disease.: Am J Health Syst Pharm. 1996 Jul 1;53(13):1598-9. Unique Identifier : AIDSLINE MED/96405143; Fish N; Kass CL; Department of Pharmacy Practice, School of Pharmacy, University of; Colorado Health Sciences Center, Denver 80262, USA.
Antibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function.: Clin Diagn Lab Immunol. 1997 Jan;4(1):104-6. Unique Identifier : AIDSLINE MED/97160995; Ando Y; Sonnerborg A; Barkholt L; Birkett A; Ericzon BG; Sallberg M; Division of Clinical Virology, Huddinge University Hospital,; Karolinska Institute, Sweden.; The influence of suppression of CD4+ and CD8+ T cells on the humoral responses to hepatitis C virus (HCV) core and nonstructural 3 proteins was studied. An increasing viral burden cannot substitute for the lack of functional T cells in maintaining humoral HCV-specific responses.
Parameters of disease progression in long-term experimental feline retrovirus (feline immunodeficiency virus and feline leukemia virus) infections: hematology, clinical chemistry, and lymphocyte subsets.: Clin Diagn Lab Immunol. 1997 Jan;4(1):33-42. Unique Identifier : AIDSLINE MED/97160982; Hofmann-Lehmann R; Holznagel E; Ossent P; Lutz H; Department of Internal Veterinary Medicine, Faculty of Veterinary; Medicine, University of Zurich, Switzerland.; rhofmann@vetklinik.unizh.ch; After several years of latency, feline immunodeficiency virus FIV) and feline leukemia virus (FeLV) cause fatal disease in the cat. The aim of this study was to determine laboratory parameters characteristic of disease progression which would allow a better description of the asymptomatic phase and a better understand
A semiquantitative assay for CD8+ T-cell-mediated suppression of human immunodeficiency virus type 1 infection.: Clin Diagn Lab Immunol. 1997 Jan;4(1):4-10. Unique Identifier : AIDSLINE MED/97160977; Chen Y; Rinaldo C; Gupta P; Department of Infectious Diseases and Microbiology, University of; Pittsburgh Graduate School of Public Health and School of Medicine,; Pennsylvania 15261, USA.; A reproducible, semiquantitative assay was developed to measure the level of the anti-human immunodeficiency virus type 1 anti-HIV-1) suppressive activity of CD8+ T cells. The assay had a wide dynamic range and could be applied to a relatively small number of fresh and cryopreserved peripheral blood mononuclear cells
In vitro immunologic and virologic effects of interleukin 15 on peripheral blood mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients.: Clin Diagn Lab Immunol. 1997 Jan;4(1):43-8. Unique Identifier : AIDSLINE MED/97160983; Lucey DR; Pinto LA; Bethke FR; Rusnak J; Melcher GP; Hashemi FN; Landay AL; Kessler HA; Paxton RJ; Grabstein K; Shearer GM; Experimental Immunology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland, USA.; Interleukin 15 (IL-15) is a cytokine that shares receptor subunits and functional activity, such as T-cell and B-cell stimulation, with IL-2 . The effect of IL-2 on immune function and human immunodeficiency virus (HIV) viral load in HIV-infected patients is being activ
Relation of impaired lymphocyte proliferative function to other major human immunodeficiency virus type 1-induced immunological changes.: Clin Diagn Lab Immunol. 1997 Jan;4(1):64-9. Unique Identifier : AIDSLINE MED/97160987; Bass HZ; Fahey JL; Nishanian P; Detels R; Cumberland W; Kemeny M; Plaeger S; Department of Microbiology and Immunology, UCLA School of Medicine,; Los Angeles, California 90095, USA.; Human immunodeficiency virus (HIV) type 1 (HIV-1) induces impairment of immune function reflected in reduced lymphocyte proliferative responses. Many other immune changes are induced by HIV-1, but their relationship to lymphocyte functional defects is not known. The present study was designed to correlate functional d
Diagnosis of human immunodeficiency virus type 1 infection in infants by immune complex dissociation p24 assay.: Clin Diagn Lab Immunol. 1997 Jan;4(1):75-8. Unique Identifier : AIDSLINE MED/97160989; Paul MO; Toedter G; Hofheinz D; Tetali S; Pelton S; Marecki M; Brena A; Abrams EJ; Landesman S; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; Using immune complex dissociation (ICD), we retrospectively examined serum and plasma of 206 infants aged 0 to 4 months who were perinatally exposed to human immunodeficiency virus (HIV). All samples were analyzed in a blinded manner. Infection status was determined based on the results of HIV culture and Centers for
Vitamin A levels and human immunodeficiency virus load in injection drug users.: Clin Diagn Lab Immunol. 1997 Jan;4(1):93-5. Unique Identifier : AIDSLINE MED/97160993; Semba RD; Farzadegan H; Vlahov D; Department of Ophthalmology, School of Medicine, Johns Hopkins; University, Baltimore, Maryland, USA. rdsemba@welchlink.welch.jhu.edu; Although low plasma vitamin A levels are associated with increased mortality and higher vertical transmission during human immunodeficiency virus (HIV) infection, it is unknown whether plasma low vitamin A levels are a marker for circulating HIV load. We conducted a cross-sectional study within a prospective cohort st
Reconstruction of the immune system after unrelated or partially matched T-cell-depleted bone marrow transplantation in children: functional analyses of lymphocytes and correlation with immunophenotypic recovery following transplantation.: Clin Diagn Lab Immunol. 1997 Jan;4(1):96-103. Unique Identifier : AIDSLINE MED/97160994; Kook H; Goldman F; Giller R; Goeken N; Peters C; Comito M; Rumelhart S; Holida M; Lee N; Trigg M; Department of Pediatrics, Chonnam University, Kwangju, Korea.; Reconstitution of the immune system following T-cell-depleted bone marrow transplantation (BMT) in children has yet to be fully elucidated. Thus, we prospectively studied the recovery of immune function in 64 children who underwent T-lymphocyte-depleted marrow transplants using either matched family member donors or m
Intrabodies: turning the humoral immune system outside in for intracellular immunization.: Gene Ther. 1997 Jan;4(1):11-5. Unique Identifier : AIDSLINE MED/97221744; Marasco WA; Division of Human Retrovirology, Dana-Farber Cancer Institute, Harvard; Medical School, Boston, MA 02115, USA.; Antibodies have long been used in biomedical science as in vitro tools for the identification, purification and functional manipulation of target antigens; they have been exploited in vivo for diagnostic and therapeutic applications as well. Recent advances in antibody engineering have now allowed the genes encoding a
Expression of small, therapeutic RNAs in human cell nuclei.: Gene Ther. 1997 Jan;4(1):45-54. Unique Identifier : AIDSLINE MED/97221749; Good PD; Krikos AJ; Li SX; Bertrand E; Lee NS; Giver L; Ellington A; Zaia JA; Rossi JJ; Engelke DR; Department of Biological Chemistry, University of Michigan, Ann Arbor; 48109-0606, USA.; Effective intracellular expression of small RNA therapeutics depends on a number of factors. The RNA, whether antisense, ribozyme, or RNA aptamer, must be efficiently transcribed, stabilized against rapid degradation, folded correctly, and directed to the part of the cell where it can be most effective. To overcome a
Bleaching injection equipment: influencing factors among IDUs who share.: Subst Use Misuse. 1996 Dec;31(14):1973-93. Unique Identifier : AIDSLINE MED/97123783; Jamner MS; Corby NH; Wolitski RJ; Center for Behavioral Research and Services, California State; University, Long Beach 90802, USA.; This study investigates factors influencing needle-bleaching intentions and behavior among IDUs who share injection equipment. Analysis of 443 interviews conducted with IDUs who share revealed that intention to bleach and frequency of bleaching were positively associated with attitudes, social norms, perceived behavio
The acquisition and maintenance of safer sexual behaviors among injection drug users.: Subst Use Misuse. 1996 Dec;31(14):1995-2015. Unique Identifier : AIDSLINE MED/97123784; Posner SF; Collins LM; Longshore D; Anglin MD; Medical Effectiveness Research Center for Diverse Populations,; University of California, San Francisco 94118, USA.; posner@itsa.ucsf.edu; The current research tests stage-sequential models of safer sexual behavior using a new method for data analysis called Latent Transition Analysis (LTA). Results are presented from data collected on 359 injection drug users participating in a seroconversion study conducted by the UCLA Drug Abuse Research Center. We id
Harm minimization approaches to drug misuse: current challenges in evaluation.: Subst Use Misuse. 1996 Dec;31(14):2017-28. Unique Identifier : AIDSLINE MED/97123785; Byrne A; Harm minimization approaches to drug misuse have become popular in recent years, particularly as a response to reducing the transmission of HIV among intravenous drug users. Harm minimization rests on the principle that many individuals will misuse drugs and that managing that misuse is more appropriate than attemptin
[Parsonage-Turner syndrome in positive HIV patients. Letter]: Rev Neurol. 1997 Jan;25(137):143. Unique Identifier : AIDSLINE MED/97210141; Botella MS; Garcia M; Cuadrado JM; Martin R
Detection of proviruses and viral RNA in the early stages of feline immunodeficiency virus infection in cats: a possible model of the early stage of HIV infection.: Exp Anim. 1997 Jan;46(1):31-9. Unique Identifier : AIDSLINE MED/97179183; Ohkura T; Shin YS; Wakamiya N; Iwa N; Kurimura T; Department of Viral Infections, Osaka University, Japan.; Feline immunodeficiency virus (FIV) infection in cats has been reported to be a useful animal model for human AIDS studies, especially in the early stages of infection. We examined the temporal changes in provirus detection in peripheral blood mononuclear cells (PBMC) and the distribution of FIV-DNA and RNA in feline
Epitope mapping of murine monoclonal antibodies against human immunodeficiency virus type 1 Nef.: Exp Anim. 1997 Jan;46(1):53-8. Unique Identifier : AIDSLINE MED/97179186; Otake K; Fujii Y; Tashiro M; Adachi A; Kitoh J; Institute for Laboratory Animal Research, Nagoya University School of; Medicine, Japan.; It has shown that the human immunodeficiency virus type 1 (HIV-1) Nef protein has the high antigenicity in HIV-1 seropostive individuals. We newly obtained seven monoclonal antibodies mAbs). To identify the antigenic determinants of HIV-1 Nef protein against murine, epitope mapping of the mAbs was performed by enzyme-
Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus.: Exp Anim. 1997 Jan;46(1):83-7. Unique Identifier : AIDSLINE MED/97179191; Fujii Y; Mukai R; Murayama Y; Akari H; Machida M; Mori K; Takasaka M; Murakami K; Yoshikawa Y; Iwakuni Research Laboratory of Technology, Nippon Paper Industries; Co., Ltd., Yamaguchi, Japan.; The efficacy of 6-chloro-2 ,3 -dideoxyguanosine (6-Cl-ddG) was investigated in vivo by using a male ARC/AIDS rhesus macaque infected with simian immunodeficiency virus (SIVmac251/32H). He was administered subcutaneously 6-Cl-ddG (50 mg/kg B.W.) every 8 hr for 14 days when he showed clinical features of recurrent weigh
HIV voluntary testing of all pregnant women.: Tenn Med. 1997 Mar;90(3):106-7. Unique Identifier : AIDSLINE MED/97212197; Turner DJ; Hagstrom RM; Tennessee Department of Health, Nashville, USA.
Retroviral proteases: structure, function and inhibition from a non-anticipated viral enzyme to the target of a most promising HIV therapy.: Biol Chem. 1996 Dec;377(12):765-74. Unique Identifier : AIDSLINE MED/97151505; von der Helm K; Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universitat, Munchen,; Germany.; Retrovirally encoded proteases are responsible for the maturation of immature viral particles yielding mature, infectious virus. This is done by apparent (auto)-processing and self-activation of the protease (PR) from a larger viral gag-PR-(pol) protein zymogen) precursor and subsequent processing of the viral reverse
Nurses' compliance with universal precautions before and after implementation of OSHA regulations [see comments]: Clin Nurse Spec. 1996 Sep;10(5):234-9. Unique Identifier : AIDSLINE MED/97222940; Ramsey PW; McConnell P; Palmer BH; Glenn LL; Department of Adult Nursing, East Tennessee State University, USA.; The principal objective of this study was to investigate whether or not nurses compliance with universal precautions procedures improved after the mandatory Occupational Safety and Health Administration regulations were implemented in 1992. Two random samples of registered nurses and licensed practical nurses registe
A scientific plan for the evaluation of alternative medicine in the treatment of HIV/AIDS.: Altern Ther Health Med. 1997 Mar;3(2):58-67. Unique Identifier : AIDSLINE MED/97215643; Standish LJ; Calabrese C; Reeves C; Polissar N; Bain S; O'Donnell T; Bastyr University AIDS Research Center, Seattle, Wash, USA.; The Bastyr University AIDS Research Center was established in October 1994 through a 3-year cooperative grant with the Office of Alternative Medicine, National Institutes of Health. The mission of the Center is to (1) describe forms and patterns of use of alternative medical therapies for HIV infection and AIDS prescr
Current methods of laboratory diagnosis of Chlamydia trachomatis infections.: Clin Microbiol Rev. 1997 Jan;10(1):160-84. Unique Identifier : AIDSLINE MED/97147006; Black CM; Division of AIDS, Sexually Transmitted Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; cxb2@ciddas1.em.cdc.gov; Infections caused by Chlamydia trachomatis are probably the most common sexually transmitted diseases in the United States . Commonly unrecognized and often inadequately treated, chlamydial infections can ascend the reproductive tract and cause pelvic inflammatory disease, which often r
Biology of Isospora spp. from humans, nonhuman primates, and domestic animals.: Clin Microbiol Rev. 1997 Jan;10(1):19-34. Unique Identifier : AIDSLINE MED/97147001; Lindsay DS; Dubey JP; Blagburn BL; Department of Pathobiology, College of Veterinary Medicine, Auburn; University, Alabama 36849-5519, USA. lindsds@vetmed.auburn.edu; Coccidial parasites of the genus Isospora cause intestinal disease in several mammalian host species. These protozoal parasites have asexual and sexual stages within intestinal cells of their hosts and produce an environmentally resistant cyst stage, the oocyst. Infections are acquired by the ingestion of infective (s
Coping with AIDS. A longitudinal study.: Am J Addict. 1997 Winter;6(1):11-20. Unique Identifier : AIDSLINE MED/97205625; Brook JS; Brook DW; Win PT; Whiteman M; Masci JR; de Catalogne J; Roberto J; Amundsen F; Department of Community Medicine, Mount Sinai School of Medicine, New; York, NY 10029, USA.; The goals of this longitudinal, prospective study were to 1) examine coping strategies of HIV-positive (HIV+) and HIV-negative HIV-) injecting drug users; 2) study the relationship of earlier social support to later coping in HIV+ men; and 3) examine the effects of earlier coping strategies on later psychosocial funct
Contrasting effects of T cell growth factors on T cell responses to melanoma in vitro.: Cancer Immunol Immunother. 1997 Jan;43(6):345-54. Unique Identifier : AIDSLINE MED/97220031; Nguyen TD; Smith MJ; Hersey P; Oncology and Immunology Unit, John Hunter Hospital, Newcastle NSW,; Australia.; Determinants of T cell responses to tumor cells remain largely unknown. In the present study we have used long-term cultures of human melanoma cells and autologous peripheral blood lymphocytes to examine the influence of cytokines with T cell growth activity on the phenotype and cytotoxic and proliferative response of
Th2-like response and antitumor effect of anti-interleukin-4 mAb in mice bearing renal cell carcinoma.: Cancer Immunol Immunother. 1997 Jan;43(6):375-81. Unique Identifier : AIDSLINE MED/97220035; Takeuchi T; Ueki T; Sasaki Y; Kajiwara T; Li B; Moriyama N; Kawabe K; Department of Urology, Faculty of Medicine, University of Tokyo,; Bunkyo-ku, Japan.; Tumor regression in experimental systems has been linked to the activities of Th1 cells. It is, therefore, conceivable that Th2 cells interrupt the expression of tumor immunity since interleukin-4 (IL-4) and IL-10 inhibit the generation of Th1 from precursors and modulate the competence of antigen-presenting cells to
Treatment regimens for patients with toxoplasmic encephalitis.: Clin Ther. 1996 Nov-Dec;18(6):1037-56; discussion 1036. Unique Identifier : AIDSLINE MED/97155108; Fung HB; Kirschenbaum HL; Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long; Island University, Brooklyn, New York, USA.; Toxoplasma gondii is an obligate intracellular parasitic protozoan that infects a variety of warm-blooded animals, including humans. Infection is usually asymptomatic in immunocompetent individuals but may be devastating in immunocompromised individuals such as those with acquired immunodeficiency syndrome (AIDS). Cli
Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of action and comparison with zidovudine.: Clin Ther. 1996 Nov-Dec;18(6):1080-92. Unique Identifier : AIDSLINE MED/97155111; Chiang G; Sassaroli M; Louie M; Chen H; Stecher VJ; Sperber K; Division of Clinical Immunology.; We have previously described the inhibition of human immunodeficiency virus serotype 1 (HIV-1) using the antimalarial hydroxychloroquine (HCQ), a weak base that inhibits the posttranslational modification of glycoprotein 120 (gp 120) in T cells and monocytes. The mechanism of inhibition of gp 120 production was presum
Changing conceptions of self and world through the spectrum of HIV disease. Implications for psychotherapy.: J Psychother Pract Res. 1997 Winter;6(1):36-44. Unique Identifier : AIDSLINE MED/97207698; Farber EW; Schwartz JA; Department of Psychiatry and Behavioral Sciences, Emory University; School of Medicine, Atlanta, GA, USA.; Individuals with HIV disease face ongoing and phasic challenges that may generate psychological stress or clinically significant distress. Such distress may in part be understood as a response to challenges to fundamental personal conceptions of self and world. The authors describe models generated from social cogniti
Suicide and suicide attempts in the lesbian and gay community.: Aust N Z J Ment Health Nurs. 1995 Dec;4(4):181-9. Unique Identifier : AIDSLINE MED/97241877; Millard J; Central Sydney Area Health Service, Rozelle, New South Wales,; Australia.; The most common suicide theories share a widely recognized set of social factors that contribute to suicide and suicide attempts. This paper discusses additional suicide risk factors that affect the gay and lesbian community such as: discrimination, gay adolescence, coming out, establishment of a gay identity, HIV/AID
Fertility, infertility and the human embryo: ethics, law and practice of human artificial procreation.: Hum Reprod Update. 1996 May-Jun;2(3):208-24. Unique Identifier : AIDSLINE MED/97233225; Evans D; Evans M; University of Wales Swansea, UK.
CD8+ cells and not CD4+ T cells are hyporesponsive to CD28- and CD40L-mediated activation in HIV-infected subjects.: Clin Exp Immunol. 1997 Mar;107(3):440-7. Unique Identifier : AIDSLINE MED/97220139; Vingerhoets J; Kestens L; Penne G; De Vuyst H; Vandenbruaene M; Pelgrom Y; Bosmans E; de Boer M; Kasran A; Azuma M; Colebunders R; Ceuppens JL; Vanham G; Laboratory of Immunology, Institute of Tropical Medicine, Antwerpen,; Belgium.; T cell dysfunction in HIV-infected subjects could be the consequence of altered sensitivity of CD4+ or CD8+ T cells to various costimulatory signals. Therefore, we studied proliferation and cytokine production in highly purified CD8+ and CD4+ T cells from HIV-infected and HIV- subjects, induced by co-activation via ce
Presence of glomerular basement membrane (GBM) antibodies in HIV- patients with Pneumocystis carinii pneumonia.: Clin Exp Immunol. 1997 Mar;107(3):448-50. Unique Identifier : AIDSLINE MED/97220140; Calderon EJ; Wichmann I; Varela JM; Respaldiza N; Regordan C; Fernandez-Alonso J; Medrano FJ; Cano S; Cuello JA; Nunez-Roldan A; Departamento de Medicina, Hospital Universitario Virgen del Rocio,; Sevilla, Spain.; Following the unexpected finding of antibodies to GBM in a patient with Pneumocystis carinii pneumonia in the absence of kidney abnormalities, the presence of anti-GBM antibodies was analysed in 14 patients with pulmonary P. carinii infection who did not have clinical evidence of autoimmune glomerulonephritis. Patient
Responsiveness of human polymorphonuclear cells (PMNL) to stimulation by a mannoprotein fraction (MP-F2) of Candida albicans; enhanced production of IL-6 and tumour necrosis factor-alpha (TNF-alpha) by MP-F2-stimulated PMNL from HIV-infected subjects.: Clin Exp Immunol. 1997 Mar;107(3):451-7. Unique Identifier : AIDSLINE MED/97220141; Torosantucci A; Chiani P; Quinti I; Ausiello CM; Mezzaroma I; Cassone A; Department of Bacteriology and Medical Mycology, Istituto Superiore di; Sanita, University of Rome La Sapienza, Italy.; IL-1beta, IL-6, IL-8 and TNF-alpha production by PMNL from 21 HIV-infected (HIV+), including 11 full-blown AIDS, and 20 HIV-uninfected (HIV-) subjects (matched for age and sex to HIV+ ones) was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and ELISA. PMNL from both categories of subjects were str
Peripheral blood T cell expansions in patients with Behcet's disease.: Clin Exp Immunol. 1997 Mar;107(3):520-7. Unique Identifier : AIDSLINE MED/97220152; Esin S; Gul A; Hodara V; Jeddi-Tehrani M; Dilsen N; Konice M; Andersson R; Wigzell H; Microbiology and Tumourbiology Centre, Karolinska Institute,; Stockholm, Sweden.; Behcet s disease (BD) is a chronic multisystemic inflammatory disorder characterized mainly by recurrent oral and genital aphthous ulcerations and uveitis. Etiology and pathogenesis of BD remain unknown. T cell receptor (TCR) V alpha/V beta gene product expression as well as Jbeta gene segment expression in peripheral
Anomalies of the CD8+ T cell pool in haemochromatosis: HLA-A3-linked expansions of CD8+CD28- T cells.: Clin Exp Immunol. 1997 Mar;107(3):548-54. Unique Identifier : AIDSLINE MED/97220156; Arosa FA; Oliveira L; Porto G; da Silva BM; Kruijer W; Veltman J; de Sousa M; Department of Molecular Immunology and Pathology, Abel Salazar; Institute for the Biomedical Sciences, University of Porto, Portugal.; The present study consists of a phenotypic and functional characterization of peripheral blood T lymphocytes in a group of 21 patients with hereditary haemochromatosis (HH), an MHC class I-linked genetic disease resulting in iron overload, and a group of 30 healthy individuals, both HLA-phenotyped. The HH patients stu
Surface antigen expression in spleen cells of C57B1/6 mice during ageing: influence of sex and parity.: Clin Exp Immunol. 1997 Mar;107(3):593-600. Unique Identifier : AIDSLINE MED/97220164; Barrat F; Lesourd BM; Louise A; Boulouis HJ; Vincent-Naulleau S; Thibault D; Sanaa M; Neway T; Pilet CH; Laboratoire de Microbiologie-Immunologie et Pathologie Generale,; Institut National de la Recherche Agronomique (INRA), Ecole Nationale; Veterinaire d'Alfort (ENVA), Maisons Alfort, France.; So far all studies on the murine ageing process have been conducted on virgin mice. Immune ageing may be influenced by sex hormone differences related to sex or pregnancies. The aim of this study was to investigate whether pregnancies and gender influence the cell changes observed during ageing in a peripheral lymphoi
Population pharmacokinetics and pharmacodynamics of pegylated-liposomal doxorubicin in patients with AIDS-related Kaposi's sarcoma.: Clin Pharmacol Ther. 1997 Mar;61(3):301-11. Unique Identifier : AIDSLINE MED/97238119; Amantea MA; Forrest A; Northfelt DW; Mamelok R; SEQUUS Pharmaceuticals, Inc., Menlo Park, CA 94025, USA.; OBJECTIVE: To characterize the population pharmacokinetics of pegylated-liposomal doxorubicin in patients with acquired immunodeficiency disease (AIDS)-related Kaposi s sarcoma and to explore the relationship between response of the cutaneous Kaposi s sarcoma lesions to treatment and measures of drug exposure. METHODS
Primary muscle lymphoma.: Clin Radiol. 1997 Mar;52(3):203-12. Unique Identifier : AIDSLINE MED/97226282; Beggs I; Department of Clinical Radiology, Royal Infirmary of Edinburgh, UK.; Primary muscle lymphoma is rare. Less than 50 cases have been described. The clinical and radiological features of muscle lymphoma are presented in this series of six cases. Most patients present with solitary or multiple masses which may be painful. Clinical presentation varies from the indolent to the rapidly progre
Causal attributions predict rate of immune decline in HIV-seropositive gay men.: Health Psychol. 1996 Nov;15(6):485-93. Unique Identifier : AIDSLINE MED/97129422; Segerstrom SC; Taylor SE; Kemeny ME; Reed GM; Visscher BR; Department of Psychology, University of California, Los Angeles 90095,; USA.; Research has suggested that attributions-the perceived causes of events-may affect psychological and physical health and the immune system. The authors hypothesized that attributions reflecting negative beliefs about the self, the future, and control would affect helper T cell (CD4) decline and onset of AIDS in indivi
Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit.: Eur J Biochem. 1997 Feb 15;244(1):235-41. Unique Identifier : AIDSLINE MED/97217448; Tozser J; Yin FH; Cheng YS; Bagossi P; Weber IT; Harrison RW; Oroszlan S; Department of Biochemistry, University Medical School of Debrecen,; Hungary.; The tethered-dimer protease of human immunodeficiency virus 1 HIV-1) [Cheng Y.-S. E., Yin, F.H., Foundling, S., Blomstrom, D. Kettner, C. A. (1990) Proc. Natl Acad. Sci. USA 87, 9660-9664] and its mutants containing amino acid substitutions or deletions or both in only one flap region were expressed in Escherichia col
High predictive value of Toxoplasma gondii IgG antibody levels in HIV-infected patients for diagnosis of cerebral toxoplasmosis.: Eur J Clin Microbiol Infect Dis. 1996 Nov;15(11):869-72. Unique Identifier : AIDSLINE MED/97151578; Hellerbrand C; Goebel FD; Disko R; Institut fur Medizinische Mikrobiologie, Technische Universitat; Munchen Klinikum rechts der Isar, Germany.; The results of serological tests for Toxoplasma gondii IgG in 31 HIV-infected patients with toxoplasmic encephalitis (TE) and 49 HIV-infected patients seropositive for Toxoplasma gondii but without TE were compared. All patient had a CD4+ lymphocyte count
Spinal cord compression due to concomitant primary lymphoma and Mycobacterium avium-intracellulare infection of the paravertebral muscles in an AIDS patient [letter]: Eur J Clin Microbiol Infect Dis. 1996 Nov;15(11):891-3. Unique Identifier : AIDSLINE MED/97151585; Moulignier A; Eliaszewicz M; Mikol J; Polivka M; Thiebaut JB; Dupont B
Viral load in relation to clinical outcome in HIV-infected children [letter]: Eur J Clin Microbiol Infect Dis. 1996 Nov;15(11):900. Unique Identifier : AIDSLINE MED/97151590; Bravo R; Cilleruelo MJ; Castilla J; Mellado MJ; Villota J; Martin-Fontelos P; Soriano V
Mother-to-child transmission of human immunodeficiency virus type 1.: Epidemiol Rev. 1996;18(2):149-57. Unique Identifier : AIDSLINE MED/97173403; John GC; Kreiss J; Department of Medicine, University of Washington, Seattle 98195, USA.; A great deal of progress has been made in our understanding of mother-to-child transmission of HIV-1. Standardization of case definitions and transmission rate calculation methodologies, and a broader array of diagnostic options for detection of infant HIV-1 infection, will enhance our ability to evaluate and compare
Specific binding of interferon-gamma to high affinity receptors on human erythroid colony-forming cells.: Exp Hematol. 1997 Mar;25(3):193-8. Unique Identifier : AIDSLINE MED/97226631; Taniguchi S; Dai CH; Krantz SB; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, Tennessee 37232-6305, USA.; Interferon-gamma (IFN-gamma) has been shown to inhibit proliferation and differentiation of erythroid progenitor cells and to produce apoptosis of erythroid cells, but IFN-gamma receptors are not present on red cells and have never been demonstrated on erythroid progenitor cells. We obtained highly purified day 6 eryt
Human immunoglobulin preparations suppress the occurrence of Epstein-Barr virus-associated lymphoproliferation.: Exp Hematol. 1997 Mar;25(3):223-31. Unique Identifier : AIDSLINE MED/97226636; Nadal D; Guzman J; Frohlich S; Braun DG; Infectious Diseases Unit, University Children's Hospital of Zurich,; Switzerland.; Suppression of Epstein-Barr virus (EBV) lymphoproliferation by three commercial human immunoglobulin (hu-Ig) preparations, one enriched with immunoglobulin A (hu-IgA-IgG) and the other two containing more than 97% immunoglobulin G (hu-IgG) with anti-EBV antibodies was studied. All three human preparations suppress EBV
In vitro synergistic inhibition of human bone marrow hemopoietic progenitor growth by a 3'-azido-3'-deoxy-thymidine, 2',3'-dideoxycytidine combination.: Exp Hematol. 1997 Mar;25(3):252-5. Unique Identifier : AIDSLINE MED/97226640; Lerza R; Castello G; Mela GS; Arboscello E; Cerruti A; Bogliolo G; Mencoboni M; Ballarino P; Pannacciulli I; Department of Internal Medicine, University of Genoa, Italy.; In vitro growth of human normal bone marrow granulocyte-macrophage colony forming units (CFU-GMs) and erythroid burst forming units (BFU-Es) was dose-dependently inhibited by 3 -azido-3 deoxythymidine ( AZT ) (from 0.1 microM to 4 microM) and 2 ,3 -dide
Brain metabolites in mice coinfected with Plasmodium berghei ANKA and LP-BM5 virus: assessment by proton magnetic resonance spectroscopy.: Exp Parasitol. 1997 Mar;85(3):296-8. Unique Identifier : AIDSLINE MED/97240466; Le Moyec L; Ekwalanga M; Eugene M; Bouanga JC; Bauza G; M'Bengue A; Mazier D; Gentilini M; Laboratoire de RMN, Hopital Saint Louis, Paris, France.
[Rectal lymphomas and human immunodeficiency virus (letter)]: Gastroenterol Clin Biol. 1997;21(1):82-3. Unique Identifier : AIDSLINE MED/97226849; Amiel V; Bernard N; Morlat P; Lacoste D; Mercie P; Loury-Lariviere I; Beylot J
Activation of human immunodeficiency virus long terminal repeat by arachidonic acid.: Free Radic Biol Med. 1997;22(1-2):195-9. Unique Identifier : AIDSLINE MED/97117059; Carini R; Leonarduzzi G; Camandola S; Musso T; Varesio L; Baeuerle PA; Poli G; Department of Experimental Medicine and Oncology, University of; Torino, Italy.; Arachidonic acid is the precursor of highly reactive mediators, including prostaglandins and leukotrienes, and the most abundant n-6 polyunsaturated fatty acid in mammalian cell membranes. It is released from phospholipids upon many inflammatory stimuli. In this study, a chloramphenicol acyltransferase reporter gene,
Immunologic and virologic characterization of the primary infiltrating cells in the aqueous humor of human T-cell leukemia virus type-1 uveitis. Accumulation of the human T-cell leukemia virus type-1-infected cells and constitutive expression of viral and interleukin-6 messenger ribonucleic acids.: Invest Ophthalmol Vis Sci. 1997 Mar;38(3):676-89. Unique Identifier : AIDSLINE MED/97224849; Ono A; Mochizuki M; Yamaguchi K; Miyata N; Watanabe T; Department of Pathology, University of Tokyo, Japan.; PURPOSE: To characterize immunologically and virologically the infiltrating cells in the aqueous humor of patients with human T-cell leukemia virus type-1 (HTLV-1) uveitis (HU). METHODS: With their informed consent, patients had 0.1 ml of the aqueous humor in the anterior chamber collected with a needle under an opera
Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. I. Taxonomy, fermentation, isolation, and physico-chemical properties and biological activities.: J Antibiot (Tokyo). 1997 Jan;50(1):58-65. Unique Identifier : AIDSLINE MED/97219467; Tanaka H; Matsuzaki K; Nakashima H; Ogino T; Matsumoto A; Ikeda H; Woodruff HB; Omura S; School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.; Chloropeptins I and II, which are gp120-CD4 binding inhibitors, were isolated as pale yellow-brown powders from the mycelia of a soil actinomycete, Streptomyces sp, WK-3419. Their physico-chemical properties showed that they are chlorinated peptides. Chloropeptin I (C61H45N7O15Cl6) is a novel compound, but chloropepti
Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I.: J Antibiot (Tokyo). 1997 Jan;50(1):66-9. Unique Identifier : AIDSLINE MED/97219468; Matsuzaki K; Ogino T; Sunazuka T; Tanaka H; Omura S; School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.; The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by 1H and 13C NMR experiments and chemical degradation. It is a peptide antibiotic consisting of six aryl amino acids residues and an alpha-oxo aryl acid some of which have chlorine atoms.
Standardization of antifungal susceptibility testing.: J Antimicrob Chemother. 1996 Oct;38(4):561-78. Unique Identifier : AIDSLINE MED/97092287; Cormican MG; Pfaller MA; Department of Pathology, University of Iowa College of Medicine, Iowa; City 52242-1009, USA.; The application of in-vitro antifungal susceptibility testing to clinical research and to the guidance of antifungal therapy has been limited by a lack of reproducibility and uncertain clinical relevance. As a result of studies of the identified variables impacting on in-vitro susceptibility results, the National Comm
Analysis of the risk factors associated with the emergence of azole resistant oral candidosis in the course of HIV infection.: J Antimicrob Chemother. 1996 Oct;38(4):691-9. Unique Identifier : AIDSLINE MED/97092298; Tumbarello M; Caldarola G; Tacconelli E; Morace G; Posteraro B; Cauda R; Ortona L; Department of Infectious Diseases, Catholic University, Rome, Italy.; The objective of this case-control study, conducted in a large Italian university hospital over a 12-month period, was to evaluate the risk factors associated with the emergence of azole resistant oral candidosis in 64 Human Immunodeficiency Virus HIV) infected patients. A swab was obtained from each patient by brushi
Gamete interactions in Xenopus laevis: identification of sperm binding glycoproteins in the egg vitelline envelope.: J Cell Biol. 1997 Mar 10;136(5):1099-108. Unique Identifier : AIDSLINE MED/97213785; Tian J; Gong H; Thomsen GH; Lennarz WJ; Department of Biochemistry and Cell Biology and the Institute for Cell; and Developmental Biology, SUNY at Stony Brook, New York 11794-5215,; USA.; A quantitative assay was developed to study the interaction of Xenopus laevis sperm and eggs. Using this assay it was found that sperm bound in approximately equal numbers to the surface of both hemispheres of the unfertilized egg, but not to the surface of the fertilized egg. To understand the molecular basis of sper
Comparison of three different hybridization assays in the quantitative measurement of serum hepatitis B virus DNA.: J Virol Methods. 1996 Dec;62(2):123-9. Unique Identifier : AIDSLINE MED/97155356; Hwang SJ; Lee SD; Lu RH; Chan CY; Lai L; Co RL; Tong MJ; Department of Medicine, Veterans General Hospital, Taipei, Taiwan,; ROC.; The measurement of hepatitis B virus (HBV) DNA, is important for monitoring and evaluating the efficacy of anti-viral agents in the treatment of patients with chronic hepatitis B. Three different hybridization assays for quantitative measurement of HBV DNA: direct membrane (dot-blot) hybridization, liquid hybridizatio
Nested PCR assays with novel primers yield greater sensitivity to Tanzanian HIV-1 samples than a commercial PCR detection kit.: J Virol Methods. 1996 Dec;62(2):131-41. Unique Identifier : AIDSLINE MED/97155357; Grankvist O; Walther L; Bredberg-R~aden U; Lyamuya E; Mhalu F; Gustafsson A; Biberfeld G; Wadell G; Department of Virology, University of Umed, Sweden.; To investigate the efficacy of the SK431/SK145 primer pair and two nested primer assays in amplifying African HIV-1 samples, a total of 35 Tanzanian PBMC samples were examined. These were assayed by two HIV-1 specific nested in-house PCR assays and a commercial HIV-1 PCR kit (GeneAmp) using SK431/SK145 as the primer p
Competitive reverse transcription-polymerase chain reaction for quantifying murine AIDS virus.: J Virol Methods. 1996 Dec;62(2):161-8. Unique Identifier : AIDSLINE MED/97155360; Desforges B; Hatin I; Akarid K; Sinet M; INSERM U13, Hopital Bichat-Claude Bernard, Paris, France.; The causative agent of murine AIDS (MAIDS) is the defective murine leukemia virus BM5d, that requires the replication-competent ecotropic MuLV (BM5e) helper virus. We developed a competitive quantitative PCR method including specific internal standards to quantify the expression of BM5d in the spleen of infected mice
Assessment of adrenal function in women heterozygous for adrenoleukodystrophy.: J Clin Endocrinol Metab. 1997 Mar;82(3):856-60. Unique Identifier : AIDSLINE MED/97216239; el-Deiry SS; Naidu S; Blevins LS; Ladenson PW; Division of Endocrinology and Metabolism, Johns Hopkins Medical; Institutions, Baltimore, Maryland 21287, USA.; Adrenoleukodystrophy (ALD) is an X-linked recessive disorder that destroys the white matter of the brain and is associated with adrenal insufficiency. The prevalence of adrenal dysfunction in 71 women carriers of the X-linked ALD gene was studied. These subjects were identified initially on the basis of being obligate
Infertility among human immunodeficiency virus-positive women: incidence and treatment dilemmas [see comments]: Hum Reprod. 1996 Dec;11(12):2793-6. Unique Identifier : AIDSLINE MED/97173487; Olaitan A; Reid W; Mocroft A; McCarthy K; Madge S; Johnson M; Department of Thoracic Medicine, Royal Free Hospital, Hampstead,; London, UK.; The increasing demand for fertility advice among human immunodeficiency virus (HIV)-positive women under our care led us to review the incidence of infertility and the ethical problems associated with its management. All HIV-positive women who attended the HIV outpatients clinic from October 1990 to the end of January
Pentoxifylline down-regulates adhesion molecule expression and inflammatory cytokine production in cultured peripheral blood mononuclear cells from patients with HTLV-I-associated myelopathy.: J Neuroimmunol. 1997 Mar;73(1-2):191-6. Unique Identifier : AIDSLINE MED/97211809; Tsujino A; Nakamura T; Nishiura Y; Shirabe S; Furuya T; Goto H; Kawakami A; Eguchi K; Nagataki S; First Department of Internal Medicine, Nagasaki University School of; Medicine, Sakamoto, Japan.; To clarify if pentoxifylline (PTX) may have therapeutic potential for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM), we investigated the in vitro effect of PTX on spontaneous proliferation of peripheral blood lymphocytes (SPP), as well as on the expression of adhesion molecules, such as l
Identification of an epitope derived from human proteolipid protein that can induce autoreactive CD8+ cytotoxic T lymphocytes restricted by HLA-A3: evidence for cross-reactivity with an environmental microorganism.: J Neuroimmunol. 1997 Mar;73(1-2):7-14. Unique Identifier : AIDSLINE MED/97211787; Honma K; Parker KC; Becker KG; McFarland HF; Coligan JE; Biddison WE; Neuroimmunology Branch, National Institute of Neurological Disorders; and Stroke, Bethesda, MD 20892, USA.; The demyelination process that occurs in the central nervous system (CNS) of patients with multiple sclerosis (MS) is in part due to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. In this study, we have identified a peptide sequence derived from the CNS-specific myelin
Anti-epiligrin cicatricial pemphigoid in a patient with HIV.: J Am Acad Dermatol. 1997 Mar;36(3 Pt 1):486-8. Unique Identifier : AIDSLINE MED/97226359; Lish KM; Washenik K; Yancey KB; Yee C; Rico MJ; New York University Department of Dermatology, NY, USA.
Dentate nuclei involvement in AIDS patients with CNS cryptococcosis: imaging findings with pathologic correlation.: J Comput Assist Tomogr. 1997 Mar-Apr;21(2):175-82. Unique Identifier : AIDSLINE MED/97224909; Ruiz A; Post MJ; Bundschu CC; Department of Radiology, University of Miami School of Medicine, FL; 33136, USA.; PURPOSE: Our goal was to describe the involvement of the dentate nuclei in AIDS patients with CNS cryptococcosis since this finding has not been emphasized in previous radiological literature. METHOD: Plain and contrast-enhanced CT of the brain 10 and 10), MR studies (1 premortem and 1 postmortem), and autopsy finding
Mycobacterium tuberculosis versus nontuberculous mycobacterial infection of the lung in AIDS patients: CT and HRCT patterns.: J Comput Assist Tomogr. 1997 Mar-Apr;21(2):312-7. Unique Identifier : AIDSLINE MED/97224935; Laissy JP; Cadi M; Cinqualbre A; Boudiaf ZE; Lariven S; Casalino E; Wolff M; Schouman-Claeys E; Department of Radiology, Hopital Bichat, Paris, France.; PURPOSE: The aim of this study was to determine discriminating CT and HRCT features between mycobacterial pulmonary tuberculosis and nontuberculous mycobacterial (NTMB) pulmonary infections in patients with AIDS. METHOD: CT and HRCT scans of 52 AIDS patients with culture-proven mycobacterial infection [29 with Mycobac
Idiopathic capillary leak syndrome: evidence of CD8-positive lymphocytes surrounding damaged endothelial cells.: J Allergy Clin Immunol. 1997 Mar;99(3):417-9. Unique Identifier : AIDSLINE MED/97211732; Cicardi M; Berti E; Caputo V; Radice F; Gardinali M; Agostoni A; Institute of Internal Medicine, University of Milan, Italy.
[Knowledge and behavior of pregnant women towards HIV infection and its screening]: J Gynecol Obstet Biol Reprod (Paris). 1997;26(1):57-63. Unique Identifier : AIDSLINE MED/97228935; Rey D; Obadia Y; Moatti JP; Gillet JY; Cravello L; Couturier E; Observatoire Regional de la Sante Provence-Alpes-Cote-d'Azur,; Marseille.; OBJECTIVES: To assess knowledge and attitudes of pregnant women towards HIV infection and testing, and to compare them according to the outcome of the pregnancy (elective abortion vs delivery). METHODS: Between March 30 and April 26, 1992, all women ending their pregnancy in a medical center located in South Eastern
Symptom-specific use of upper gastrointestinal endoscopy in human immunodeficiency virus-infected patients yields high dividends.: J Clin Gastroenterol. 1996 Dec;23(4):292-8. Unique Identifier : AIDSLINE MED/97116645; Bashir RM; Wilcox CM; Department of Medicine, Emory University School of Medicine, Atlanta,; Georgia, USA.; The yield of upper gastrointestinal endoscopy esophago-gastroduodenoscopy; EGD) in human immunodeficiency virus (HIV)-infected patients based on presenting symptoms has not been well studied. We studied consecutive patients with documented HIV infection undergoing EGD at a large innercity hospital between August 1, 19
Cryptosporidiosis in HIV infection.: J Commun Dis. 1996 Dec;28(4):241-4. Unique Identifier : AIDSLINE MED/97210374; Anand L; Brajachand NG; Dhanachand CH; Life Sciences Department, Manipur University, Canchipur.; Preserved faecal specimens (10 per cent Buffer formalin), from 150 HIV infected persons having symptomatic diarrhoea and 50 non-diarrhoeal apparently healthy people aged between 15-30 years were examined to detect the presence of cryptosporidium infection. 70 diarrhoeal patients (46.6 per cent) were found to excrete t
HTLV-I in HIV seropositive Indian blood donors.: J Commun Dis. 1996 Dec;28(4):270-2. Unique Identifier : AIDSLINE MED/97210378; Malhotra VL; Lakshmy A; Department of Microbiology, Lady Hardinge Medical College, New Delhi.; One hundred HIV seropositive blood donors were screened for the presence of antibodies to HTLV-I by passive agglutination test from 1994 to 1996. Thirty two percent of the HIV-I seropositive blood donors were found to be positive for HTLV-I (Titre 1:16). Only Six percent of the HIV-seronegative donors were found to be
Tuberculosis in Kentucky: current recommendations for empiric therapy [see comments]: J Ky Med Assoc. 1997 Mar;95(3):98-101. Unique Identifier : AIDSLINE MED/97225500; Wojda B; Ahkee S; Uyamadu N; Jouja K; Ramirez JA; Division of Infectious Diseases, University of Louisville School of; Medicine, Louisville, KY 40292, USA.; Current guidelines for empiric therapy for pulmonary tuberculosis depend on the presence of INH or INH and rifampin resistance MDRTB) in the community. The objective of this study was to determine the susceptibility of MTB in Kentucky and to consider which therapeutic modality for empiric therapy should be followed. T
Update: hemophilia surveillance project [news]: J Okla State Med Assoc. 1997 Feb;90(2):72. Unique Identifier : AIDSLINE MED/97221120
State HIV/AIDS cases reach 2622 [news]: J Okla State Med Assoc. 1997 Feb;90(2):73. Unique Identifier : AIDSLINE MED/97221121
Breast abscesses in Nigeria: lactational versus non-lactational [letter; comment]: J R Coll Surg Edinb. 1997 Feb;42(1):61. Unique Identifier : AIDSLINE MED/97198046; Cotton MH
Molecular docking to ensembles of protein structures.: J Mol Biol. 1997 Feb 21;266(2):424-40. Unique Identifier : AIDSLINE MED/97199397; Knegtel RM; Kuntz ID; Oshiro CM; Department of Pharmaceutical Chemistry, School of Pharmacy, University; of California, San Francisco 94143-0446, USA.; Until recently, applications of molecular docking assumed that the macromolecular receptor exists in a single, rigid conformation. However, structural studies involving different ligands bound to the same target biomolecule frequently reveal modest but significant conformational changes in the target. In this paper, t
Molecular phylogeny of human T-cell leukemia virus type I and II of Amerindians in Colombia and Chile.: J Mol Evol. 1997;44 Suppl 1:S76-82. Unique Identifier : AIDSLINE MED/97224631; Miura T; Yamashita M; Zaninovic V; Cartier L; Takehisa J; Igarashi T; Ido E; Fujiyoshi T; Sonoda S; Tajima K; Hayami M; Research Center for Immunodeficiency Virus, Kyoto University, Japan.; Six human T-cell leukemia virus type I (HTLV-I) and eight human T-cell leukemia virus type II (HTLV-II) cases newly isolated from the South American countries of Colombia and Chile were analyzed t
Methadone maintenance and other factors associated with intraindividual temporal trends in injection-drug use.: J Subst Abuse Treat. 1996 May-Jun;13(3):241-8. Unique Identifier : AIDSLINE MED/97170024; Shore RE; Marmor M; Titus S; Des Jarlais DC; Department of Environmental Medicine, New York University School of; Medicine, NY, USA.; The objective of this study was to determine what sociodemographic, lifestyle, or drug-related characteristics predict temporal changes in self reported drug injection frequencies among HIV-seronegative injection-drug users (IDUs) who were being given HIV testing and risk reduction counseling. The 277 subjects were gi
What happens when a demonstration project ends. Consequences for a clinic and its clients.: J Subst Abuse Treat. 1996 May-Jun;13(3):249-56. Unique Identifier : AIDSLINE MED/97170025; Grella CE; Anglin MD; Rawson R; Crowley R; Hasson A; UCLA Drug Abuse Research Center 90024, USA. grella@ucla.edu; The Los Angeles Enhanced Methadone Maintenance Project was a 5-year research demonstration project funded by the National Institute on Drug Abuse with the goal of reducing high-risk behavior for human immunodeficiency virus (HIV) among heroin users. A clinic was established for the purposes of the study and 500 client
Estimates of infectious disease risk factors in US blood donors. Retrovirus Epidemiology Donor Study [see comments]: JAMA. 1997 Mar 26;277(12):967-72. Unique Identifier : AIDSLINE MED/97228032; Williams AE; Thomson RA; Schreiber GB; Watanabe K; Bethel J; Lo A; Kleinman SH; Hollingsworth CG; Nemo GJ; American Red Cross Blood Services, Holland Laboratory, Rockville, MD; 20855, USA.; OBJECTIVE: Individuals who do not respond accurately to questions about infectious disease risk factors at the time of blood donation represent a potential threat to the safety of the blood supply. This study was designed to estimate the prevalence of undetected behavioral and other risks in current blood donors. DESI
[Chronic granulomatous chorioretinitis in tuberculosis]: Klin Monatsbl Augenheilkd. 1996 Dec;209(6):376-9. Unique Identifier : AIDSLINE MED/97164092; Haring G; Nolle B; Kiehne K; Wiechens B; Klinik fur Ophthalmologie, Christian-Albrechts-Universitat zu Kiel.; BACKGROUND: Though the incidence of tuberculosis decreased substantially during the second half of the century, a steady increase of new cases has been observed within the last decade. Among other reasons, the growing number of immunodeficient patients (e.g. HIV, therapy with immunosuppressive agents) and migration fr
Inhibition of proliferation and CD25 down-regulation by retinoic acid in human adult T cell leukemia cells.: Leukemia. 1997 Mar;11(3):401-7. Unique Identifier : AIDSLINE MED/97220205; Miyatake JI; Maeda Y; Third Department of Internal Medicine, Kinki University School of; Medicine, Osaka, Japan.; The effects of retinoic acid (RA) on the cell growth and expression of interleukin-2 ( IL-2 ) receptors (IL-2R alpha/p55, Tac, CD25) by the human T lymphotropic virus type I HTLV-I)-positive T cell lines, HUT102 and ATL-2 were investigated. Incubation of these cells for
Human T cell leukemia/lymphoma virus type I (HTLV-I) and Pneumocystis carinii associated with T cell proliferation and haemophagocytic syndrome [letter]: Leukemia. 1997 Mar;11(3):453-4. Unique Identifier : AIDSLINE MED/97220215; Roudier M; Lamaury I; Strobel M
Peripherally inserted central catheters in general medicine.: Mayo Clin Proc. 1997 Mar;72(3):225-33. Unique Identifier : AIDSLINE MED/97223313; Ng PK; Ault MJ; Ellrodt AG; Maldonado L; Division of General Internal Medicine, Cedars-Sinai Medical Center,; Los Angeles, California 90048, USA.; OBJECTIVE: To report the success rate and complications associated with peripherally inserted central venous catheters PICCs) and to compare costs between PICCs and centrally inserted central catheters. MATERIAL AND METHODS: We undertook a cohort study of the first 1,000 patients referred to the PICC service of a larg
Infectious human herpesvirus 8 in a healthy North American blood donor [see comments]: Lancet. 1997 Mar 1;349(9052):609-11. Unique Identifier : AIDSLINE MED/97210669; Blackbourn DJ; Ambroziak J; Lennette E; Adams M; Ramachandran B; Levy JA; Department of Medicine, University of California, San Francisco; 94143-1270, USA.; BACKGROUND: Molecular studies have provided strong evidence for the association of human herpesvirus 8 (HHV-8) with Kaposi s sarcoma. These data have been supported by serological studies, which have also suggested that HHV-8 can be found in the healthy population. We report the presence of infectious HHV-8 in a healt
Loss to follow-up effect in investigations of HIV-1 incidence [letter; comment]: Lancet. 1997 Mar 1;349(9052):649-50. Unique Identifier : AIDSLINE MED/97210687; Beyrer C; Nelson KE
False-positive self-reports of HIV infection [letter; comment]: Lancet. 1997 Mar 1;349(9052):650. Unique Identifier : AIDSLINE MED/97210688; Chintu C; Baboo KS; Gould SS; DuPont HL; Murphy JR
Activation of HHV-8 by HIV-1 tat [letter]: Lancet. 1997 Mar 15;349(9054):774-5. Unique Identifier : AIDSLINE MED/97228503; Harrington W Jr; Sieczkowski L; Sosa C; Chan-a-Sue S; Cai JP; Cabral L; Wood C
Clearance of HHV-8 from peripheral blood mononuclear cells with a protease inhibitor [letter]: Lancet. 1997 Mar 15;349(9054):775-6. Unique Identifier : AIDSLINE MED/97228504; Rizzieri DA; Liu J; Traweek ST; Miralles GD
Investigators study morning-after AIDS treatment [news]: Lancet. 1997 Mar 15;349(9054):780. Unique Identifier : AIDSLINE MED/97228509; Macready N
AIDS/HIV information database [news]: MCN Am J Matern Child Nurs. 1997 Mar-Apr;22(2):106. Unique Identifier : AIDSLINE MED/97221146
Study of HIV prevention in primary care [news]: MCN Am J Matern Child Nurs. 1997 Mar-Apr;22(2):106. Unique Identifier : AIDSLINE MED/97221145
ANA document helps school nurses deal with HIV/AIDS [news]: MCN Am J Matern Child Nurs. 1997 Mar-Apr;22(2):107. Unique Identifier : AIDSLINE MED/97221147
Pregnant and HIV-positive: a case study.: MCN Am J Matern Child Nurs. 1997 Mar-Apr;22(2):85-8. Unique Identifier : AIDSLINE MED/97221140; Harkey AV; Southeast Missouri State University, Cape Girardeau, USA.
A likelihood method for the detection of selection and recombination using nucleotide sequences.: Mol Biol Evol. 1997 Mar;14(3):239-47. Unique Identifier : AIDSLINE MED/97219492; Grassly NC; Holmes EC; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Department of Zoology, University of Oxford, U.K.; nicholas.grassly@zoo.ox.ac.uk; Different regions along nucleotide sequences are often subject to different evolutionary forces. Recombination will result in regions having different evolutionary histories, while selection can cause regions to evolve at different rates. This paper presents a statistical method based on likelihood for detecting such
New therapies: new hope. Reports from the International Nursing Satellite symposium and the Eleventh International Conference on AIDS, Vancouver, Canada, 6-12 July, 1996.: Midwifery. 1996 Dec;12(4):205-6. Unique Identifier : AIDSLINE MED/97223029
HIV prevalence and risk behaviour in needle exchange attenders: a national study. The Collaboration of Australian Needle Exchanges.: Med J Aust. 1997 Mar 3;166(5):237-40. Unique Identifier : AIDSLINE MED/97230835; MacDonald M; Wodak AD; Ali R; Crofts N; Cunningham PH; Dolan KA; Kelaher M; Loxley WM; van Beek I; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research, Sydney,; NSW.; OBJECTIVE: To determine whether needle and syringe exchange programs represent feasible sites to describe the prevalence of HIV and related risk behaviour among injecting drug users. DESIGN: Cross-sectional survey. SETTING: 21 needle and syringe exchange programs in all Australian jurisdictions. PARTICIPANTS: All pers
Enteral nutrition in immunocompromised patients.: Nutr Clin Pract. 1997 Feb;12(1 Suppl):S25-7. Unique Identifier : AIDSLINE MED/97232019; Kirby DF; Division of Gastroenterology, Virginia Commonwealth University,; Medical College of Virginia Hospitals, Richmond, USA.
HIV-infected health care workers: the disclosure dilemma.: Mo Med. 1997 Feb;94(2):82-4. Unique Identifier : AIDSLINE MED/97202907; Amrein TW
Mutagenesis by human immunodeficiency virus reverse transcriptase: incorporation of O6-methyldeoxyguanosine triphosphate.: Mutat Res. 1997 Mar 4;374(1):41-50. Unique Identifier : AIDSLINE MED/97220039; Hizi A; Kamath-Loeb AS; Rose KD; Loeb LA; Department of Pathology, University of Washington, Seattle 98195, USA.; The high frequency of incorporation of non-complementary nucleotides by HIV-1 reverse transcriptase is likely to be a major factor in the exceptionally rapid accumulation of viral mutations during the course of AIDS infections. To investigate whether this high level of infidelity is also associated with the incorporat
Analysis of myopathy in a placebo-controlled zidovudine trial.: Muscle Nerve. 1997 Mar;20(3):382-5. Unique Identifier : AIDSLINE MED/97205320; Simpson DM; Slasor P; Dafni U; Berger J; Fischl MA; Hall C; Department of Neurology, Mount Sinai Medical Center, New York, New; York 10029, USA.
Muscle involvement in human immunodeficiency virus-infected patients is associated with marked selenium deficiency.: Muscle Nerve. 1997 Mar;20(3):386-9. Unique Identifier : AIDSLINE MED/97205321; Chariot P; Dubreuil-Lemaire ML; Zhou JY; Lamia B; Dume L; Larcher B; Monnet I; Levy Y; Astier A; Gherardi R; Department of Toxicology, Hopital Henri Mondor, Creteil, France.
Cerebral syphilitic gumma [letter; comment]: N Engl J Med. 1997 Apr 3;336(14):1027; discussion 1027-8. Unique Identifier : AIDSLINE MED/97222399; Quinn P; Weisberg L
Monoclonal origin of multicentric Kaposi's sarcoma lesions [see comments]: N Engl J Med. 1997 Apr 3;336(14):988-93. Unique Identifier : AIDSLINE MED/97222381; Rabkin CS; Janz S; Lash A; Coleman AE; Musaba E; Liotta L; Biggar RJ; Zhuang Z; Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD; 20892, USA.; BACKGROUND: Kaposi s sarcoma has features of both hyperplastic proliferation and neoplastic growth. Multiple lesions, in which spindle cells are prominent, often arise synchronously over widely dispersed areas. We tested the hypothesis that the spindle cells in these multicentric lesions originate from a single clone
Images in clinical medicine. Cutaneous cryptococcosis.: N Engl J Med. 1997 Apr 3;336(14):998. Unique Identifier : AIDSLINE MED/97222383; Baker DJ; Reboli AC; University of Medicine and Dentistry of New Jersey/Robert Wood Johnson; Medical School at Camden, 08103, USA.
Sexual transmission of HIV.: N Engl J Med. 1997 Apr 10;336(15):1072-8. Unique Identifier : AIDSLINE MED/97224095; Royce RA; Sena A; Cates W Jr; Cohen MS; Department of Epidemiology, University of North Carolina, Chapel Hill; 27599, USA.
Postexposure treatment of people exposed to the human immunodeficiency virus through sexual contact or injection-drug use [see comments]: N Engl J Med. 1997 Apr 10;336(15):1097-100. Unique Identifier : AIDSLINE MED/97224100; Katz MH; Gerberding JL; San Francisco Department of Public Health, CA 94102-6033, USA.
Serotypes of Cryptococcus neoformans isolated from patients prior to and during the AIDS era in Thailand.: Mycopathologia. 1996;135(2):75-8. Unique Identifier : AIDSLINE MED/97216849; Sukroongreung S; Nilakul C; Ruangsomboon O; Chuakul W; Eampokalap B; Department of Clinical Microbiology, Faculty of Medical Technology,; Mahidol University, Bangkok, Thailand.; One hundred and eighty-seven strains of Cryptococcus neoformans isolated from patients in Thailand were characterized by biochemical varieties relating to serogroups. Canavanine-glycine-bromothymol blue (CGB) agar was used for differentiating the varieties of C. neoformans. Slide
Plea to drop charges in French HIV scandal [news]: Nature. 1997 Mar 20;386(6622):210. Unique Identifier : AIDSLINE MED/97222123
Working with AIDS patients [letter]: N J Med. 1997 Mar;94(3):8. Unique Identifier : AIDSLINE MED/97225515; Gauch RR
Tuberculosis in children with acquired immunodeficiency syndrome.: Pediatr Radiol. 1997 Feb;27(2):186-8. Unique Identifier : AIDSLINE MED/97181009; Haller JO; Ginsberg KJ; Department of Radiology, State University of New York, Health Science; Center at Brooklyn, 450 Clarkson Avenue, Box 1198, Brooklyn, NY 11203,; USA.; With AIDS related tuberculosis in the pediatric population on the rise, we review our experience with 14 such children. A brief review of the pertinent literature is also presented.
Dideoxyinosine-induced pancreatitis in human immunodeficiency virus-infected children.: Pediatr Radiol. 1997 Feb;27(2):189-91. Unique Identifier : AIDSLINE MED/97181010; Levin TL; Berdon WE; Tang HB; Haller JO; Department of Radiology, Division of Pediatric Radiology, Babies and; Children's Hospital of New York-Columbia Presbyterian Medical Center,; 3959 Broadway, BHN 3-318, New York, NY 10032, USA.; Dideoxyinosine (ddI) is a widely used antiretroviral agent in treatment of HIV infection. Pancreatitis is a serious side effect. Two cases are reported, one with rapid development of a pseudocyst.
Monocyte phagolysosomal fusion in children born to human immunodeficiency virus-infected mothers.: Pediatr Infect Dis J. 1997 Jan;16(1):24-8. Unique Identifier : AIDSLINE MED/97155395; Pittis MG; Prada F; Mangano A; Perez L; Sternik G; Redondo J; Bologna R; Sen L; Laboratorio de Biologia Celulary y Retrovirus, Hospital de Pediatria; Juan P. Garrahan, Buenos Aires, Argentina.; BACKGROUND: Previously we demonstrated that monocyte phagolysosomal fusion is impaired in chronic HIV infection in adult patients. METHODS: We studied the phagolysosomal fusion of peripheral blood monocytes from 45 children vertically infected with HIV, 38 noninfected infants born to HIV-positive mothers and 14 childr
Low risk of congenital toxoplasmosis in children born to women infected with human immunodeficiency virus [letter]: Pediatr Infect Dis J. 1997 Jan;16(1):84. Unique Identifier : AIDSLINE MED/97155412; Dunn D; Newell ML; Gilbert R
The pharmacokinetics of TNP-470, a new angiogenesis inhibitor.: Pharmacotherapy. 1997 Jan-Feb;17(1):91-7. Unique Identifier : AIDSLINE MED/97170239; Figg WD; Pluda JM; Lush RM; Saville MW; Wyvill K; Reed E; Yarchoan R; Clinical Pharmacokinetics Section, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; STUDY OBJECTIVE: To characterize the pharmacokinetic profile of TNP-470, a synthetic analog of fumagillin that is a potent inhibitor of angiogenesis and inhibits neovascularization in several solid tumor models. DESIGN: A dose-escalation phase I clinical trial. SETTING: The National Institutes of Health. PATIENTS: Pat
Complications of immunizations.: Pediatr Rev. 1997 Feb;18(2):66-7. Unique Identifier : AIDSLINE MED/97181800; Agha R; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx,; NY, USA.
Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing [comment]: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1615-8. Unique Identifier : AIDSLINE MED/97203108; Unutmaz D; Littman DR; Skirball Institute for BioMolecular Medicine, New York University; Medical Center, New York, NY 10016, USA.
Choosing the right sugar: how polymerases select a nucleotide substrate.: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1619-22. Unique Identifier : AIDSLINE MED/97203109; Joyce CM; Department of Molecular Biophysics and Biochemistry, Yale University,; New Haven, CT 06520, USA. catherine.joyce@yale.edu
DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1811-5. Unique Identifier : AIDSLINE MED/97203143; Fu GK; Grosveld G; Markovitz DM; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0642, USA.; The product of the dek oncogene is the 43-kDa DEK nuclear protein. DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the la
Analysis of HIV-1 env gene sequences reveals evidence for a low effective number in the viral population.: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1862-5. Unique Identifier : AIDSLINE MED/97203152; Brown AJ; Centre for HIV Research, Institute of Cell, Animal and Population; Biology, University of Edinburgh, Scotland. A.Leigh-Brown@ed.ac.uk; Selection is usually considered to be the dominant force controlling viral variation; the large population sizes suggest that deterministic population genetic models are appropriate. To investigate their validity for HIV, samples of env gene sequences were tested for departure from neutrality because of mutation-selec
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection.: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1890-5. Unique Identifier : AIDSLINE MED/97203157; Price DA; Goulder PJ; Klenerman P; Sewell AK; Easterbrook PJ; Troop M; Bangham CR; Phillips RE; Nuffield Department of Clinical Medicine, John Radcliffe Hospital,; Oxford, United Kingdom.; Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical f
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes [see comments]: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1925-30. Unique Identifier : AIDSLINE MED/97203163; Bleul CC; Wu L; Hoxie JA; Springer TA; Mackay CR; The Center for Blood Research and Harvard Medical School, Department; of Pathology, Boston, MA 02115, USA.; The chemokine receptors CXCR4 and CCR5 function as coreceptors for HIV-1 entry into CD4+ cells. During the early stages of HIV infection, viral isolates tend to use CCR5 for viral entry, while later isolates tend to use CXCR4. The pattern of expression of these chemokine receptors on T cell subsets and their regulatio
Glutathione deficiency is associated with impaired survival in HIV disease.: Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1967-72. Unique Identifier : AIDSLINE MED/97203170; Herzenberg LA; De Rosa SC; Dubs JG; Roederer M; Anderson MT; Ela SW; Deresinski SC; Herzenberg LA; Department of Genetics, Stanford University Medical School, CA; 94305-5125, USA.; Glutathione (GSH), a cysteine-containing tripeptide, is essential for the viability and function of virtually all cells. In vitro studies showing that low GSH levels both promote HIV expression and impair T cell function suggested a link between GSH depletion and HIV disease progression. Clinical studies presented her
Psychological stress, neuroimmunomodulation, and susceptibility to infectious diseases in animals and man: a review.: Psychother Psychosom. 1997;66(1):3-26. Unique Identifier : AIDSLINE MED/97149917; Biondi M; Zannino LG; III Clinica Psichiatrica, University of Rome, La Sapienza, Italy.; This article reviews research on the role of psychological stress, personality, social support and other psychosocial factors in bacterial, viral and parasitic infections. After 100 years of research on man and animals, psychological stress is considered as a potential cofactor in the pathogenesis of infectious diseas
The role of NEF in the primate Lentivirus life cycle. Proceedings of the 5th Forum in Virology.: Res Virol. 1997 Jan-Feb;148(1):21-81. Unique Identifier : AIDSLINE MED/97238449
Towards a consensus for a role of Nef in both viral replication and immunomodulation?: Res Virol. 1997 Jan-Feb;148(1):23-30. Unique Identifier : AIDSLINE MED/97170300; Collette Y; Inserm U119, Institut Paoli Calmettes, Marseille, France.
The multifaceted role of HIV Nef.: Res Virol. 1997 Jan-Feb;148(1):30-3. Unique Identifier : AIDSLINE MED/97170301; Mangasarian A; Trono D; Infectious Disease Laboratory, Salk Institute for Biological Studies,; La Jolla, CA 92037, USA.
The positive influence of Nef on viral infectivity.: Res Virol. 1997 Jan-Feb;148(1):34-7. Unique Identifier : AIDSLINE MED/97170302; Guatelli JC; Department of Medicine, University of California San Diego, USA.
The nef gene of human immunodeficiency virus type-1 (HIV1) is required for optimal virus replication in fully activated primary T lymphocytes.: Res Virol. 1997 Jan-Feb;148(1):38-43. Unique Identifier : AIDSLINE MED/97170303; Vicenzi E; Turchetto L; Poli G; AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific; Institute, Milan, Italy.
Analysis of Nef-induced MHC-I endocytosis.: Res Virol. 1997 Jan-Feb;148(1):43-7. Unique Identifier : AIDSLINE MED/97170304; Le Gall S; Heard JM; Schwartz O; Laboratoire Retrovirus et Transfert Genetique, URA CNRS 1157, Institut; Pasteur, Paris.
Nef and the Nef-associated kinase.: Res Virol. 1997 Jan-Feb;148(1):47-52. Unique Identifier : AIDSLINE MED/97170305; Sawai ET; Cheng-Mayer C; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616, USA.
The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck.: Res Virol. 1997 Jan-Feb;148(1):52-8. Unique Identifier : AIDSLINE MED/97170306; Collette Y; Dutartre H; Benziane A; Olive D; INSERM U119, Marseille, France.
HIV1 Nef: the Machiavelli of cellular activation.: Res Virol. 1997 Jan-Feb;148(1):58-64. Unique Identifier : AIDSLINE MED/97170307; Greenway A; McPhee D; AIDS Cellular Biology Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield, Victoria, Australia.
Regulation of Nef function.: Res Virol. 1997 Jan-Feb;148(1):64-8. Unique Identifier : AIDSLINE MED/97170308; Luo T; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, TN 38101, USA.
Analysis of the interactions between Nef and cellular proteins.: Res Virol. 1997 Jan-Feb;148(1):68-70. Unique Identifier : AIDSLINE MED/97170309; Coates K; Boulton V; Cooke S; Mann D; Harris M; Department of Veterinary Pathology, University of Glasgow, Scotland,; UK.
Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein.: Res Virol. 1997 Jan-Feb;148(1):71-3. Unique Identifier : AIDSLINE MED/97170310; Benichou S; Liu LX; Erdtmann L; Selig L; Benarous R; INSERM U332, Laboratoire de Genetique Moleculaire des Interactions; Proteiques, Institut Cochin de Genetique Moleculaire, Paris.
[Symptomatic primary human immunodeficiency virus infection]: Rev Med Interne. 1997;18(1):37-46. Unique Identifier : AIDSLINE MED/97227003; Bachmeyer C; Grateau G; Sereni D; Departement de medecine interne, hopital Laennec, Creil, France.; Symptomatic primary human immunodeficiency virus (HIV) infection was originally defined as a mononucleosis-like syndrome, with or without lymphocytic meningitis, associated with seroconversion for HIV. However, other protean clinical manifestations have been reported, and diagnosis should be considered in patients wit
[Anti-retrovirus agents in AIDS: therapeutic strategy and prospectives for the future]: Rev Med Interne. 1997;18(2):100-5. Unique Identifier : AIDSLINE MED/97227013
Absence of retroviral antibodies in the sera of patients with systemic lupus erythematosus.: Singapore Med J. 1996 Oct;37(5):479-81. Unique Identifier : AIDSLINE MED/97198125; Fong KY; Boey ML; Yuen M; Nadarajah M; Feng PH; Department of Rheumatology and Immunology, Tan Tock Seng Hospital,; Singapore.; Retroviruses have been postulated as environmental triggers in the aetiopathogenesis of systemic lupus erythematosus. Sera from 100 lupus patients were screened for the presence of antibodies against recombinant HIV-1 core and envelope, and HIV-2 envelope antigens by an enzyme immunoassay. This will detect antibodies
Counting the uncatchable? An epidemiological method for counting drug misusers.: Soc Psychiatry Psychiatr Epidemiol. 1997 Jan;32(1):19-23. Unique Identifier : AIDSLINE MED/97181846; Cox S; Shipley M; Academic Department of Psychiatry, Middlesex Hospital, London, UK.; Service provision and treatment outcome for problem drug users are receiving increased attention, although both are hindered by the lack of good epidemiological data. A technique of population enumeration called capture recapture methodology (CRM) is currently being advocated for use in populations that are otherwise
[Management strategies in HIV/AIDS at the family level]: Salud Publica Mex. 1997 Jan-Feb;39(1):32-43. Unique Identifier : AIDSLINE MED/97213551; Castro R; Eroza E; Orozco E; Manca MC; Hernandez JJ; Centro de Investigacion en Sistemas de Salud, Instituto Nacional de; Salud Publica, Mexico.; OBJECTIVE: To identify the critical points of the trajectories of the families of persons with AIDS which may serve as a basis to develop educational and support programs. THEORY AND METHODS: A qualitative investigation was conducted in 1995 in Ciudad Netzahualcoyotl, State of Mexico
[Main results of statistics on mortality in Mexico, 1995]: Salud Publica Mex. 1997 Jan-Feb;39(1):85-91. Unique Identifier : AIDSLINE MED/97213560
Treatment regimens of STD patients in Cameroon: a need for intervention.: Sex Transm Dis. 1994 Mar-Apr;21(2):124-6. Unique Identifier : AIDSLINE MED/97225052; Trebucq A; Louis JP; Tchupo JP; Migliani R; Smith J; Delaporte E; Organisation de coordination pour la lutte contre les endemies en; Afrique Centrale (OCEAC), Yaounde, Cameroon.; BACKGROUND AND OBJECTIVES: The management of patients with STDs is an important element in the fight against AIDS. To define effective STD control strategies a survey was carried out to understand the attitudes of STD patients and the treatment regimens they follow. STUDY DESIGN: The study was based on interviews with
HIV and syphilis seroprevalence among clients with sexually transmitted diseases attending a walk-in clinic at Cook County Hospital.: Sex Transm Dis. 1994 Mar-Apr;21(2):93-6. Unique Identifier : AIDSLINE MED/97225046; Ansell DA; Hu TC; Straus M; Cohen M; Sherer R; Department of Medicine, Cook County Hospital, Chicago, Illinois 60612,; USA.; BACKGROUND AND OBJECTIVES: To determine the HIV and syphilis seroprevalence in a patients with suspected sexually transmitted diseases at an urban walk-in clinic. METHODS: Between January and November 1991, 515 patients with suspected sexually transmitted diseases were simultaneously tested for syphilis and HIV antibo
Patterns and trends of sexual behavior, HIV testing, and HIV prevalence among all sexually transmitted disease clinic attenders in Denmark.: Sex Transm Dis. 1994 Mar-Apr;21(2):97-102. Unique Identifier : AIDSLINE MED/97225047; Smith E; Worm AM; Jepsen LV; Larsen J; Brandrup F; Veien N; Andersen BL; Department of Epidemiology, Statens Seruminstitut, Copenhagen,; Denmark.; BACKGROUND AND OBJECTIVES: Persons attending a sexually transmitted disease (STD) clinic have shown to be at a higher risk for HIV infection than the population in general. We evaluate the patterns of HIV prevalence and testing in relation to reported risk behavior. STUDY DESIGN: Data have been collected on all new at
Complicated anorectal sepsis.: Surg Clin North Am. 1997 Feb;77(1):115-53. Unique Identifier : AIDSLINE MED/97226453; Gilliland R; Wexner SD; Department of Colorectal Surgery, Cleveland Clinic Florida, Fort; Lauderdale, USA.; These complex anorectal conditions are difficult to diagnose because clinical features overlap. In general, an aggressive approach is reserved for hidradenitis suppurativa and necrotizing infections. Patients with Crohn s disease, hematologic disorders, or AIDS are often treated more conservatively, but the correct ti
Bacteria-associated hemophagocytic syndrome in childhood acute lymphoblastic leukemia: report of two cases.: Chung Hua Min Kuo Hsiao Erh Ko I Hsueh Hui Tsa Chih. 1996 Nov-Dec;37(6):466-70. Unique Identifier : AIDSLINE MED/97228210; Hsiao CC; Huang SC; Department of Pediatrics, Chang Gung Children's Hospital, Kaohsiung,; Taiwan, R.O.C.; Two children with acute lymphoblastic leukemia presenting with cellulitis and sepsis are described. Both presented as having hemophagocytic syndrome with the manifestations of prolonged fever, jaundice, pancytopenia, coagulopathy and histiocytic proliferation with hemophagocytosis in their bone marrows. It is similar
Neutralization of human immunodeficiency virus type 1 (HIV-1) with antibody from carriers' plasma against HIV-1 protein p17.: Acta Virol. 1996 Sep;40(4):195-200. Unique Identifier : AIDSLINE MED/97166278; Kageyama S; Katsumoto T; Taniguchi K; Ismail SI; Shimmen T; Sasao F; Gao M; Owatari S; Wakamiya N; Tsuchie H; Ueda S; Shiraki K; Kurimura T; Department of Virology, Faculty of Medicine, Toyama Medical and; Pharmaceutical University, Japan.; It was investigated whether human antibody against HIV-1 protein p17 (anti-p17) in HIV carriers plasma has the ability to neutralize the infectivity of HIV. By the pretreatment of HIV-1 with anti-p17 from HIV carriers, progeny HIV-1 production from cells infected with virus pretreated with anti-p17 was suppressed and
CT of small-bowel lymphoma in immunocompetent patients and patients with AIDS: comparison of findings.: AJR Am J Roentgenol. 1997 Mar;168(3):675-80. Unique Identifier : AIDSLINE MED/97210440; Balthazar EJ; Noordhoorn M; Megibow AJ; Gordon RB; Radiology Department, New York University-Tisch Medical Center, NY; 10016, USA.; OBJECTIVE: The purpose of this study was to describe and analyze the CT features of small-bowel lymphoma, compare those features with the radiographic presentation in immunocompetent patients and patients with AIDS, and discuss the role of CT in the initial detection and evaluation of this disease. MATERIALS AND METHO
HIV colitis: clinical and radiographic findings.: AJR Am J Roentgenol. 1997 Mar;168(3):681-2. Unique Identifier : AIDSLINE MED/97210441; Solomon JA; Levine MS; O'Brien C; Jacobs JE; Department of Radiology, Hospital of the University of Pennsylvania,; Philadelphia 19104, USA.
Behavioral and psychiatric aspects of HIV infection.: Am Fam Physician. 1997 Mar;55(4):1227-37, 1241-2. Unique Identifier : AIDSLINE MED/97226074; Searight HR; McLaren AL; Department of Family Medicine, Deaconess Health Care System, St.; Louis, MO 63139, USA.; Primary care physicians frequently care for patients who test positive for human immunodeficiency virus (HIV) infection or who have acquired immunodeficiency syndrome. These patients often have concomitant behavioral and psychiatric problems that complicate their clinical care. Counseling before and after HIV testing
Cryptosporidiosis in HIV-infected patients: diagnostic sensitivity of stool examination, based on number of specimens submitted.: Am J Gastroenterol. 1997 Mar;92(3):451-3. Unique Identifier : AIDSLINE MED/97221421; Blackman E; Binder S; Gaultier C; Benveniste R; Cecilio M; Department of Pathology, Midway Hospital Medical Center, Los Angeles,; California, USA.; OBJECTIVES: To determine the optimal number of stool specimens needed for the diagnosis of cryptosporidiosis. METHODS: Four hundred thirty-five admissions were reviewed (291 patients) in which stool specimens were examined for Cryptosporidium parvum oocysts (mean of 1.47 specimens per admission), using a modified acid
AIDS and pure red cell aplasia [letter; comment]: Am J Hematol. 1997 Mar;54(3):264. Unique Identifier : AIDSLINE MED/97220134; Stricker RB; Goldberg B
Primary non-Hodgkin's lymphoma of the liver in a patient with hepatitis B, C, HIV infections [letter]: Am J Hematol. 1997 Mar;54(3):265. Unique Identifier : AIDSLINE MED/97220136; Bauduer F; Marty F; Gemain MC; Dulubac E; Bordahandy R
Skin involvement with Pneumocystis despite dapsone prophylaxis: a rare cause of skin nodules in a patient with AIDS.: Am J Med Sci. 1997 Mar;313(3):182-6. Unique Identifier : AIDSLINE MED/97229873; Bundow DL; Aboulafia DM; Division of Hematology/Oncology, Virginia Mason Medical Center,; Seattle, WA 98111, USA.; Pneumocystis carinii pneumonia is among the most common life-threatening opportunistic infections that occurs in those with HIV infection and a depleted absolute CD4+ T-lymphocyte count. Fortunately, with the advent of effective prophylaxis, this AIDS-defining complication is diminishing. Rarely, Pneumocystis carinii
Vertical transmission of toxoplasma by human immunodeficiency virus-infected women.: Am J Obstet Gynecol. 1997 Mar;176(3):555-9. Unique Identifier : AIDSLINE MED/97232331; Minkoff H; Remington JS; Holman S; Ramirez R; Goodwin S; Landesman S; Department of Obstetrics and Gynecology, State University of New York; Health Science Center at Brooklyn, 11203, USA.; OBJECTIVE: Our goal was to determine the frequency of mother-to-child transmission of Toxoplasma gondii from human immunodeficiency virus-infected mothers who are also chronically infected with T. gondii. STUDY DESIGN: One hundred thirty-eight women were entered into a prospective study of human immunodeficiency virus
Effect of a retroviral immunodeficiency syndrome on murine cytomegalovirus-induced hepatitis.: Am J Pathol. 1997 Mar;150(3):1089-100. Unique Identifier : AIDSLINE MED/97214464; Peacock CD; Olver SD; Price P; Department of Microbiology, University of Western Australia, Nedlands,; Australia.; We have studied the effects of LP-BM5 MuLV-induced murine acquired immunodeficiency syndrome (MAIDS) on concomitant murine cytomegalovirus (MCMV) infection in the livers of C57BL mice. A delayed inflammatory response in livers of mice with MAIDS (M+) on day 4 was associated with im
Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.: Am J Pathol. 1997 Mar;150(3):823-32. Unique Identifier : AIDSLINE MED/97214440; Parronchi P; Romagnani P; Annunziato F; Sampognaro S; Becchio A; Giannarini L; Maggi E; Pupilli C; Tonelli F; Romagnani S; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy.; Crohn s disease (CD) is a chronic bowel inflammatory disorder in which the pathogenic role of immune alterations has been suggested, but the immunologic mechanisms responsible for the inflammatory reaction are still poorly understood. We investigated the profile of cytokine secretion by T-cell clones generated from gu
Kaposi's sarcoma cells express the macrophage-associated antigen mannose receptor and develop in peripheral blood cultures of Kaposi's sarcoma patients.: Am J Pathol. 1997 Mar;150(3):929-38. Unique Identifier : AIDSLINE MED/97214451; Uccini S; Sirianni MC; Vincenzi L; Topino S; Stoppacciaro A; Lesnoni La Parola I; Capuano M; Masini C; Cerimele D; Cella M; Lanzavecchia A; Allavena P; Mantovani A; Baroni CD; Ruco LP; Department of Experimental Medicine and Pathology, University of Rome; La Sapienza, Italy.; The mannose receptor (MR) is a surface 175-kd C-type lectin expressed by macrophages and dendritic cells. MR is involved in removal of effete cells, phagocytosis of mannose-coated particles, pinocytosis, and antigen presentation. Expression of MR was investigated in 17 biopsies of Kaposi s sarcoma (3 AIDS KS, 13 class
Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity.: Am J Pathol. 1997 Mar;150(3):963-70. Unique Identifier : AIDSLINE MED/97214454; Khakoo SI; Soni PN; Savage K; Brown D; Dhillon AP; Poulter LW; Dusheiko GM; Academic Department of Medicine, Royal Free Hospital, London, United; Kingdom.; The pathogenesis of chronic hepatitis C and the mechanisms underlying progressive liver disease in patients with chronic hepatitis C infection are poorly understood. To demonstrate which inflammatory cells might be responsible for the necroinflammatory damage in chronic hepatitis C infection, we have correlated the ph
[Cyclospora sp]: Ann Biol Clin (Paris). 1996;54(10-11):373-9. Unique Identifier : AIDSLINE MED/97226693; Deluol AM; Junod CH; Laboratoire de parasitologie-mycologie, hopital Rothschild, Paris,; France.; A few years ago, a new Coccidian, Cyclospora sp , has been found in the stools of both immuno-competents and AIDS patients with diarrhoeal illness. The epidemiology, natural history and clinical manifestations of Cyclospora infection have been charted, but its life cycle has not been described yet. We present here 19
Oral administration of bovine lactoferrin for treatment of intractable stomatitis in feline immunodeficiency virus FIV)-positive and FIV-negative cats.: Am J Vet Res. 1996 Oct;57(10):1443-6. Unique Identifier : AIDSLINE MED/97052046; Sato R; Inanami O; Tanaka Y; Takase M; Naito Y; Department of Veterinary Internal Medicine, Faculty of Agriculture,; Iware University, Morioka, Japan.; OBJECTIVE: To study the effects of oral administration of bovine lactoferrin (LF) on intractable stomatitis in feline immunodeficiency virus (FIV)-positive and FIV-negative cats, and phagocytosis of neutrophils in healthy and ill cats, simultaneously. ANIMALS: 7 ill cats with diagnosis of intractable stomatitis (4 FIV
Cytotoxic interactions of 5-fluorouracil and nucleoside analogues in vitro.: Anticancer Res. 1997 Jan-Feb;17(1A):21-7. Unique Identifier : AIDSLINE MED/97219326; Li YX; Coucke PA; Paschoud N; Mirimanoff RO; Department of Radiation Oncology, Centre Hospitalier Universitaire; Vaudois (CHUV), Lausanne, Switzerland.; The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine ( AZT ), 3 -deoxy-2 , 3 -didehydrothymidine (D4T), 5-iodode
Severe stress, depressive symptoms, and changes in lymphocyte subsets in human immunodeficiency virus-infected men. A 2-year follow-up study.: Arch Gen Psychiatry. 1997 Mar;54(3):279-85. Unique Identifier : AIDSLINE MED/97229906; Leserman J; Petitto JM; Perkins DO; Folds JD; Golden RN; Evans DL; Department of Psychiatry, University of North Carolina School of; Medicine, Chapel Hill, USA.; BACKGROUND: This study examined how severe stress and depressive symptoms were related to changes in immune measures during a 2-year period in a sample of gay men with human immunodeficiency virus (HIV) infection. These analyses follow up our initial cross-sectional observations that severe stress was correlated with
Ocular manifestations of the human immunodeficiency virus and the acquired immunodeficiency syndrome in developing countries [letter]: Arch Ophthalmol. 1997 Mar;115(3):435. Unique Identifier : AIDSLINE MED/97230797; Lewallen S
Human immunodeficiency virus infection: a review of the mode of infection, pathogenesis, disease course, and the general and clinical manifestations.: Aust Dent J. 1997 Feb;42(1):30-7. Unique Identifier : AIDSLINE MED/97233709; McCullough MJ; Firth NA; Reade PC; School of Dental Science, Faculty of Medicine, Dentistry and Health; Science, University of Melbourne.; Acquired immunodeficiency syndrome (AIDS) was first recognized in 1981 and in 1983 the virus responsible for this syndrome, the human immunodeficiency virus, was first isolated. There has been an increasing understanding of the many aspects related to infection with this virus and this review discusses the historical
Human T-cell leukemia virus-1 encoded Tax protein transactivates alpha 1-->3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin ligand expressed on adult T-cell leukemia cells.: Biochem Biophys Res Commun. 1997 Feb 3;231(1):183-6. Unique Identifier : AIDSLINE MED/97223424; Hiraiwa N; Hiraiwa M; Kannagi R; Program of Experimental Pathology, Aichi Cancer Center, Nagoya, Japan.; Leukemia cells in patients with adult T-cell leukemia (ATL) and related cell lines strongly express the carbohydrate determinant sialyl Lewis X, a ligand for selectins. Its expression is thought to be related closely to the extravascular infiltration of the leukemia cells. Human T-cell leukemia virus type 1 (HTLV-1),
HIV/AIDS epidemiology in the United States--where do we stand? [editorial]: Pediatr AIDS HIV Infect. 1996 Feb;7(1):1-8. Unique Identifier : AIDSLINE MED/97229592
Anti-HIV-1 antibody avidity is correlated with clinical status in infected children.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):14-9. Unique Identifier : AIDSLINE MED/97229594; Sciascia C; Palomba E; Gay V; Tovo PA; Department of Pediatrics, University of Turin, Italy.; Avidity of antibodies to gp41 and p24, CD4 cell count, and free and dissociated p24 antigen were assessed in 37 HIV-1-infected children, in order to evaluate whether the avidity of anti-HIV-1 antibodies is related to the disease status in perinatally infected children. The HIV-infected children were divided into two g
CD4 and CD8 lymphocytes in diagnosis and disease progression of pediatric HIV infection.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):20-30. Unique Identifier : AIDSLINE MED/97229595; Aldhous MC; Raab GM; Mok JY; Doherty KV; Bird AG; Froebel KS; Centre for HIV Research, University of Edinburgh, Scotland.; Vertical infection with human immunodeficiency virus-1 (HIV-1) causes profound changes in the proportions of subpopulations of lymphocytes in the peripheral circulation. In this study the percentages in whole blood of CD4 and CD8 cells, and of immunologically important subpopulations, were measured in 19 HIV-infected
Different patterns of some systemic immunological cell markers in HIV only, and HIV/hepatitis C-infected children.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):31-6. Unique Identifier : AIDSLINE MED/97229596; Voiculescu CL; Balasoiu M; Turculeanu A; Radu C; Avramescu C; Radu E; Department of Microbiology and Immunology, Faculty of Medicine; Craiova, Romania.; In three groups of children, aged 4-6 years (i.e., human immunodeficiency virus [HIV]-negative controls, HIV-seropositive, and dually HIV/hepatitis C virus (HCV)-seropositive), two types of immunological investigations in blood cells were performed: a) numerical assays, consisting of flow cytometric measurement of dif
Maternal HIV-1 RNA serum levels at delivery and vertical transmission in Uganda.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):37-42. Unique Identifier : AIDSLINE MED/97229597; Jackson JB; Hom D; Piwowar E; Ndugwa C; Kataaha P; Marum L; Guay L; Parsons J; Olness K; Mmiro F; Institute of Pathology, Case Western Reserve University, Cleveland,; OH, USA.; OBJECTIVE: To evaluate the clinical utility of maternal HIV-1 RNA serum levels at delivery in predicting the rate of HIV-1 vertical transmission. DESIGN AND METHODS: HIV-1 RNA levels were determined by the Roche Amplicor Monitor assay in serum specimens collected at the time of delivery from 94 transmitting and 107 no
Molluscum contagiosum, involving the upper eyelids, in a child infected with HIV-1.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):43-6. Unique Identifier : AIDSLINE MED/97229598; Pelaez CA; Gurbindo MD; Cortes C; Munoz-Fernandez MA; Division of Ophthalmology, Hospital General Universitario Gregorio; Maranon, Universidad Complutense de Madrid.; BACKGROUND: Infection with molluscum contagiosum has been reported in pediatric and adult patients with acquired immune deficiency syndrome (AIDS), but rarely affecting eyelids. We have studied the viral phenotype, HIV-1 plasma viremia, p24 antigenemia, alterations of cellular immune function, and the ophthalmological
Treatment trials currently open to pregnant women, children, and adolescents.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):47-57. Unique Identifier : AIDSLINE MED/97229599
House approves mandatory HIV testing of newborns.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):61. Unique Identifier : AIDSLINE MED/97229600
From the Centers for Disease Control and Prevention. Health Information for International Travel 1995.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):62-3. Unique Identifier : AIDSLINE MED/97229601
CDC National AIDS Clearinghouse.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):64. Unique Identifier : AIDSLINE MED/97229602
CDC National AIDS Hotline.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):65. Unique Identifier : AIDSLINE MED/97229603
Respect yourself, protect yourself. Public service announcements.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):66-7. Unique Identifier : AIDSLINE MED/97229604
Pediatric antiretroviral therapy: from research to practice.: Pediatr AIDS HIV Infect. 1996 Feb;7(1):9-13. Unique Identifier : AIDSLINE MED/97229593; Farley J; Vink P; Department of Pediatrics, University of Maryland School of Medicine,; Baltimore, USA.
New medicines in development for AIDS: 1995 survey from the Pharmaceutical Research and Manufacturers of America.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):120-1. Unique Identifier : AIDSLINE MED/97229609
AIDS medicines in development.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):122-31. Unique Identifier : AIDSLINE MED/97229610
Kynostatin 272.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):132-4. Unique Identifier : AIDSLINE MED/97229611
Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act of 1990: the laws and their impact on students with HIV infection/AIDS entering postsecondary education.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):139-41. Unique Identifier : AIDSLINE MED/97229612
Issues in the design of clinical trials for safety in HIV-infected children.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):69-82. Unique Identifier : AIDSLINE MED/97229605; Lindsey JC; Kline MW; Center for Biostatistics in AIDS Research, Harvard School of Public; Health, Boston, Massachusetts 02115, USA.; The use of newly approved drugs for human immunodeficiency virus HIV)-infected adults is limited in children until child-specific pharmacokinetic and safety data can be submitted to the Food and Drug Administration ( FDA ) to fulfill labeling requirements. Design of a clinical trial to
Failure to thrive in HIV-infected children: incidence, prevalence, and clinical correlates.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):83-90. Unique Identifier : AIDSLINE MED/97229606; Myhre JA; Chadwick EG; Yogev R; Department of Pediatrics, Children's Memorial Hospital, Northwestern; University Medical School, Chicago, Illinois 60614, USA.; Failure to thrive is a frequent component of the acquired immunodeficiency syndrome (AIDS) in childhood. This retrospective study was conducted to document the incidence, prevalence, and clinical correlates of failure to thrive in a cohort of 97 HIV-infected children seen at a large urban teaching hospital over an
Longitudinal growth during the first 2 years of life in children born to HIV-infected mothers in Malawi, Africa.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):91-7. Unique Identifier : AIDSLINE MED/97229607; Henderson RA; Miotti PG; Saavedra JM; Dallabetta G; Chiphangwi J; Liomba G; Taha TE; Yolken RH; Department of Pediatrics, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; To evaluate the longitudinal growth patterns of infants born to HIV-infected and uninfected mothers in Malawi , Africa, 92 HIV-infected infants, 270 uninfected infants born to HIV-infected mothers, and 686 infants born to uninfected mothers between birth and 24 months of life were s
Evidence for tuberculous infection in Romanian HIV-positive children by enzyme-linked immunosorbent assay.: Pediatr AIDS HIV Infect. 1996 Apr;7(2):98-102. Unique Identifier : AIDSLINE MED/97229608; Ispas D; Stavri D; Ionescu S; Geafar SL; Zahir S; Paun L; "Dr. V. Babes" Clinic for Infectious and Tropical Diseases, University; of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.; The pandemic spread of tuberculosis (TB) and human immunodeficiency virus (HIV) represents a serious world problem. The diagnosis of TB in developing countries remains difficult, particularly in patients with concomitant HIV infection. Anergia to tuberculin frequently occurs in HIV-positive patients with pulmonary or
Youth and HIV/AIDS: an American agenda. A report to the President. Executive summary of a report prepared by the Office of National AIDS Policy.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):307-9. Unique Identifier : AIDSLINE MED/97220410
Factors associated with disclosure of diagnosis to children with HIV/AIDS.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):310-24. Unique Identifier : AIDSLINE MED/97220411; Wiener LS; Battles HB; Heilman N; Sigelman CK; Pizzo PA; Pediatric Branch, National Cancer Institute, Bethesda, Maryland, USA.; Disclosure of the diagnosis of human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS) to a child is a controversial and emotionally laden issue. To understand the factors that affect the process of disclosure and its consequences, we studied 99 parent-child dyads recruited from patie
Viral studies of mothers with human immunodeficiency virus infection at delivery and their infants in the first 3 days of life.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):325-30. Unique Identifier : AIDSLINE MED/97220412; Sison AV; Brandt CD; Rakusan TA; Wientzen R; Fuccillo DA; Sever JL; Department of Obstetrics and Gynecology, Georgetown University School; of Medicine, Washington, D.C., USA.; OBJECTIVE: We studied 49 mother-infant pairs for human immunodeficiency virus (HIV) (a) to assess the virological and immunological status of HIV-infected mothers at delivery and their infants within the first 3 days of the infant s life, and b) to correlate these findings with eventual infection outcome in the infant
The use of back projection to estimate HIV prevalence among pregnant women in Australia.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):331-6. Unique Identifier : AIDSLINE MED/97220413; Law MG; Dore G; McDonald A; Kaldor J; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, Darlinghurst, Australia.; A statistical method similar to back projection was used to estimate the number of children infected with HIV perinatally from the number of children with AIDS due to perinatal HIV infection. By 31 December 1994 there were 18 children born in Australia and reported to have AIDS
Impact of on-site social work services on the documentation of client and family-centered information: the experience of Ryan White CARE Act (Title IV) pediatric program sites in Maryland.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):337-45. Unique Identifier : AIDSLINE MED/97220414; Palenicek JG; Hidalgo J; Hutton N; Weiss B; Center for AIDS Services Planning and Development, AIDS; Administration, Maryland Department of Health and Mental Hygiene,; Baltimore, USA.; BACKGROUND: The purpose of this study is to (1) describe client and maternal demographic, social, and medical characteristics of pediatric clients receiving medical and social services at Ryan White (Title IV) program sites, and (2) determine the impact of on-site social work services in documenting client and family-
HIV-1 and hepatitis B virus infections in adolescents lodged in security institutes of Buenos Aires.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):346-9. Unique Identifier : AIDSLINE MED/97220415; Avila MM; Casanueva E; Piccardo C; Liberatore D; Cammarieri G; Cervellini M; Gojman I; Libonatti O; Department of Microbiology, University of Buenos Aires School of; Medicine, Argentina.; The goal of this study was to determine the prevalence of human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) infections in street youth lodged in security institutes, from February 1992 to March 1995, to correlate these infections with nontherapeutic drug use, and to compare these results with a p
Seronegative HIV disease with seroconversion at 15 months in an infant with advanced AIDS.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):350-1. Unique Identifier : AIDSLINE MED/97220416; Secord E; Bakshi S; Fikrig S; Pahwa S; Department of Pediatric Immunology, State University of New York; Health Science Center at Brooklyn, USA.
HIV/AIDS: figures and trends mid-1996 estimates.: Pediatr AIDS HIV Infect. 1996 Oct;7(5):390-3. Unique Identifier : AIDSLINE MED/97220417
Antiribonucleoprotein antibodies in children with human immunodeficiency virus infection: comparative study with childhood-onset systemic lupus erythematosus.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):401-8. Unique Identifier : AIDSLINE MED/97229621; Gonzalez CM; Lopez-Longo FJ; Monteagudo I; Grau R; Rodriguez-Mahou M; St-Cyr C; Lapointe N; Carreno L; Rheumatology Service, Gregorio Maranon Hospital, Universidad; Complutense de Madrid, Spain.; A number of clinical and laboratory features of human immunodeficiency virus (HIV) infection are found in systemic lupus erythematosus (SLE). OBJECTIVE: To analyze the presence of circulating antibodies to small nuclear ribonucleoproteins snRNP) in both diseases. METHODS: We studied sera from 44 HIV-infected children,
Antigliadin antibodies in HIV-infected children.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):409-12. Unique Identifier : AIDSLINE MED/97229622; Zuin G; Fontana M; Morelli A; Sangaletti O; Marchisio P; Principi N; Pediatric Department Four, University of Milan Medical School, Italy.; Immunoglobulin A-antigliadin antibodies and total immunoglobulin A were assessed on serum samples from 52 children infected by Human Immunodeficiency Virus (HIV). Titers of antigliadin antibodies exceeding the normal range were found in 14 children 27%). No statistically significant difference was observed either betw
Elevated levels of circulating intercellular adhesion molecule 1 and tumor necrosis factor alpha in the serum of children vertically infected with HIV-1.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):413-7. Unique Identifier : AIDSLINE MED/97229623; Obregon E; Borner C; Navarro J; Gurbindo MD; Fernandez-Cruz E; Munoz-Fernandez MA; Division of Immunology, Hospital General Universitario Gregorio; Maranon, Madrid, Spain.; OBJECTIVE: To evaluate serum levels of circulating intercellular adhesion molecule-1 (cICAM-1) and tumor necrosis factor-alpha TNF-alpha) levels in HIV-1-infected children at different stages of infection in children treated or not treated with Zidovudine ZDV). DESIGN: Serum levels of cICAM-1 and TNF-alpha, determined
Issues of disclosure and condom use in adolescents with hemophilia and HIV. Hemophilia Behavioral Evaluative Intervention Project Staff.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):418-23. Unique Identifier : AIDSLINE MED/97229624; Geary MK; King G; Forsberg AD; Delaronde SR; Parsons J; New England Hemophilia Center, Medical Center of Central; Massachusetts, Worcester, USA.; PURPOSE: To examine the patterns, facilitators, and barriers to disclosure of HIV seropositivity in an adolescent population and to determine the relationship between disclosure and condom use. BACKGROUND: In recent years, public health efforts have focused on methods to prevent the transmission of the Human Immunodef
Thyroid dysfunction in HIV-infected children: is L-thyroxine therapy beneficial?: Pediatr AIDS HIV Infect. 1996 Dec;7(6):424-8. Unique Identifier : AIDSLINE MED/97229625; Rana S; Nunlee-Bland G; Valyasevi R; Iqbal M; Department of Pediatrics, Howard University College of Medicine, USA.; PURPOSE: To assess thyroid function in symptomatic HIV-infected infants and children with failure to thrive and to evaluate clinical response in patients with hyperthyrotropinemia to levothyroxine. METHODS: We evaluated 11 children (mean age: 1.5 years; males = 5, females = 6) with HIV infection and failure to thrive
Disseminated Bacillus Calmette-Guerin infection in HIV-infected children: case report and review.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):429-32. Unique Identifier : AIDSLINE MED/97229626; Campos JM; Simonetti JP; Pone MV; Carvalho LA; Pereira AC; Garrido JR; Department of Pediatrics, Fernandes Figueira Institute, Oswaldo Cruz; Foundation, Rio de Janeiro, Brazil.
11th International Conference on AIDS. Part 2. Vancouver, Canada, July 1996. Selected abstracts.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):437-75. Unique Identifier : AIDSLINE MED/97246416
From the World Health Organization. Joint United Nations Programme on HIV/AIDS (UNAIDS) HIV and Infant Feeding: an interim statement.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):476-7. Unique Identifier : AIDSLINE MED/97229627
Tap water and HIV.: Pediatr AIDS HIV Infect. 1996 Dec;7(6):478. Unique Identifier : AIDSLINE MED/97229628
Something to give to your children [editorial]: Pediatr AIDS HIV Infect. 1997 Feb;8(1):1-2. Unique Identifier : AIDSLINE MED/97229629; Ginzburg R; Mack K
Screening for human immunodeficiency virus infection during pregnancy.: Pediatr AIDS HIV Infect. 1997 Feb;8(1):12-4. Unique Identifier : AIDSLINE MED/97229632; Ross EL; Morrison JC; Department of Obstetrics and Gynecology, University of Mississippi; Medical Center, Jackson 39216, USA.; Due to the increased risk of human immunodeficiency virus (HIV) infection during the childbearing years, voluntary screening during the prenatal period has been suggested. To study the impact of such a program in our population of pregnant women, we offered HIV testing to all prenatal patients with informed consent, b
Evaluation of the role of routine serial cranial computed tomography in the management of children with human immunodeficiency virus infection.: Pediatr AIDS HIV Infect. 1997 Feb;8(1):15-22. Unique Identifier : AIDSLINE MED/97229633; King SM; Edwards V; Blaser S; Smith ML; Rieder M; Read SE; Department of Paediatrics, Hospital for Sick Children.; OBJECTIVE: To review the impact of routine follow-up cranial computed tomography (CT) scans on the management of children with human immunodeficiency virus (HIV) infection. DESIGN: Longitudinal data collected from 58 HIV-infected children followed in one center for mean of 3.8 +/- 1.8 years. SETTING: HIV/AIDS pediatri
Knowledge and attitudes of adolescents about AIDS and HIV infection.: Pediatr AIDS HIV Infect. 1997 Feb;8(1):3. Unique Identifier : AIDSLINE MED/97229630; Nahata MC; Nahata L; Ohio State University, Columbus, USA.
Treatment trials open to pregnant women and children.: Pediatr AIDS HIV Infect. 1997 Feb;8(1):34-66. Unique Identifier : AIDSLINE MED/97229634
Cost-effectiveness of recombinant human erythropoietin versus transfusions in the treatment of zidovudine-related anemia in HIV-infected children.: Pediatr AIDS HIV Infect. 1997 Feb;8(1):4-11. Unique Identifier : AIDSLINE MED/97229631; Allen UD; Kirby MA; Goeree R; Department of Pediatrics, Children's Hospital of Eastern Ontario,; Ottawa, Canada.; The objectives of this study were to compare the costs and benefits of recombinant human erythropoietin (r-HuEPO) relative to repeated transfusions in the treatment of zidovudine AZT )-related anemia among HIV-infected children. The study was based on
New medicines in development for AIDS. 1996 survey from the Pharmaceutical Research and Manufacturers of America.: Pediatr AIDS HIV Infect. 1997 Feb;8(1):67-78. Unique Identifier : AIDSLINE MED/97229635
From the World Health Organization. Acquired immunodeficiency syndrome (AIDS)--data as of 20 November 1996.: Pediatr AIDS HIV Infect. 1997 Feb;8(1):79-83. Unique Identifier : AIDSLINE MED/97229636
We're closing in on HIV [editorial]: Aids Patient Care STDS. 1996 Oct;10(5):278-9. Unique Identifier : AIDSLINE MED/97229560; Laurence J
Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect.: Aids Patient Care STDS. 1996 Oct;10(5):280-1. Unique Identifier : AIDSLINE MED/97229561; Harris PJ; AIDS Clinical Research Center of Washington, Washington, D.C., USA.; Trimetrexate glucuronate, a dihydrofolate reductase inhibitor related to methotrexate, was developed by Parke-Davis as an alternative antineoplastic agent for tumors, especially sarcomas, that had developed resistance to methotrexate. This is a report on a patient with AIDS who developed Pneumocystis carinii pneumonia
Delirium in AIDS patients: discrepancy between occurrence and health care provider identification.: Aids Patient Care STDS. 1996 Oct;10(5):282-7. Unique Identifier : AIDSLINE MED/97229562; Lalonde B; Uldall KK; Berghuis JP; Northwest AIDS Education and Training Center, University of; Washington, Seattle, USA.
Resource utilization and stage of illness: a study of an outpatient AIDS clinic.: Aids Patient Care STDS. 1996 Oct;10(5):288-91. Unique Identifier : AIDSLINE MED/97229563; Bavry A; Mauldin PD; College of Medicine, University of Florida, Gainesville, USA.; Since the early 1990s, the trend in AIDS patient care has been to increase utilization of outpatient services, resulting in less frequent aggressive and lengthy hospital stays. This study retrospectively analyzes financial and sociodemographic data of 240 HIV/AIDS patients in a large, infectious disease program in Atl
Attitudes of nurses caring for HIV/AIDS patients.: Aids Patient Care STDS. 1996 Oct;10(5):292-5. Unique Identifier : AIDSLINE MED/97229564; Gillispie LC; Davis BA; Huntington Internal Medicine Group, West Virginia, USA.; BACKGROUND: HIV/AIDS remains in epidemic proportions worldwide. The incidence of HIV/AIDS among infants, children, adolescents, and women has risen rapidly, and nurses cannot avoid HIV/AIDS patients. Because HIV/AIDS is associated with certain risk groups that have historically been subjects of discrimination, it has
Psychosocial correlates of quality of life in patients with HIV infection.: Aids Patient Care STDS. 1996 Oct;10(5):296-8. Unique Identifier : AIDSLINE MED/97229565; Grassi L; Sighinolfi L; Consultation-Liaison Psychiatry Service, Department of Psychiatry,; University of Ferrara, Italy.
HIV infection among Brazilian transvestites in a prison population.: Aids Patient Care STDS. 1996 Oct;10(5):299-302. Unique Identifier : AIDSLINE MED/97229566; Varella D; Tuason L; Proffitt MR; Escaleira N; Alquezar A; Bukowski RM; CPT-Objetivo/Unip, Fundacao, Saul Brandalise, Brazil.; Eighty-two male transvestites imprisoned in Casa de Detencao Sao Paulo, Brazil ) were tested for HIV antibodies, and completed a questionnaire investigating their demographics, arrest and imprisonment records, sexual practices, and drug use. Data were then analyzed to evaluate the i
HIV/AIDS case histories: diagnostic problems. Thrombotic thrombocytopenia purpura (TTP).: Aids Patient Care STDS. 1996 Oct;10(5):303. Unique Identifier : AIDSLINE MED/97229567; Godwin JH; Kripas C; Cornell University Medical College, USA.
Public policy update: an AmFAR report.: Aids Patient Care STDS. 1996 Oct;10(5):304-5. Unique Identifier : AIDSLINE MED/97229568; Silver J
Predicting survival: viral load vs. T cell count.: Aids Patient Care STDS. 1996 Oct;10(5):306. Unique Identifier : AIDSLINE MED/97229569
Ritonavir increases lymphocyte subsets [news]: Aids Patient Care STDS. 1996 Oct;10(5):307-8. Unique Identifier : AIDSLINE MED/97229570
Long-acting AZT accompanied by less resistance and fewer side effects [news]: Aids Patient Care STDS. 1996 Oct;10(5):308. Unique Identifier : AIDSLINE MED/97229572
Saquinavir plus ritonavir open-label study recruiting [news]: Aids Patient Care STDS. 1996 Oct;10(5):308. Unique Identifier : AIDSLINE MED/97229571
Triple therapy in previously untreated patients reduces viral load below limit of detection [news]: Aids Patient Care STDS. 1996 Oct;10(5):308-9. Unique Identifier : AIDSLINE MED/97229573
Evidence of decline in perinatal HIV transmission [news]: Aids Patient Care STDS. 1996 Oct;10(5):309. Unique Identifier : AIDSLINE MED/97229574
Fluconazole prevents yeast infections in women with HIV [news]: Aids Patient Care STDS. 1996 Oct;10(5):310. Unique Identifier : AIDSLINE MED/97229576
Rifabutin levels may increase with fluconazole during MAC treatment [news]: Aids Patient Care STDS. 1996 Oct;10(5):310. Unique Identifier : AIDSLINE MED/97229575
Industry, governments, and nonprofits worldwide join effort to develop AIDS vaccine [news]: Aids Patient Care STDS. 1996 Oct;10(5):310-1. Unique Identifier : AIDSLINE MED/97229577
Experimental cancer compound may be of benefit for AIDS-lymphoma [news]: Aids Patient Care STDS. 1996 Oct;10(5):311. Unique Identifier : AIDSLINE MED/97229578
Neurex launches phase III program for SNX-111 for the treatment of chronic pain [news]: Aids Patient Care STDS. 1996 Oct;10(5):311-2. Unique Identifier : AIDSLINE MED/97229579
Interleukin-2 injections produce sustained increases in CD4+ T cell counts in early-stage HIV disease [news]: Aids Patient Care STDS. 1996 Oct;10(5):312. Unique Identifier : AIDSLINE MED/97229580
NIAID study rules out high-dose clarithromycin for AIDS-related MAC [news]: Aids Patient Care STDS. 1996 Oct;10(5):313. Unique Identifier : AIDSLINE MED/97229581
Clearance to market azithromycin as prevention for a common OI in advanced AIDS [news]: Aids Patient Care STDS. 1996 Oct;10(5):313-4. Unique Identifier : AIDSLINE MED/97229582
Hyperthermia studies begin [news]: Aids Patient Care STDS. 1996 Oct;10(5):314. Unique Identifier : AIDSLINE MED/97229583
Encouraging data on quality of life reported for IL-2 therapy [news]: Aids Patient Care STDS. 1996 Oct;10(5):314-5. Unique Identifier : AIDSLINE MED/97229584
Option agreement for license to develop and commercialize new HIV/AIDS therapeutic [news]: Aids Patient Care STDS. 1996 Oct;10(5):315. Unique Identifier : AIDSLINE MED/97229585
FDA panel finds insufficient data to approve antimicrobial glove [news]: Aids Patient Care STDS. 1996 Oct;10(5):316. Unique Identifier : AIDSLINE MED/97229586
Targeting friendship groups increases teenage condom use to prevent HIV and other STDs [news]: Aids Patient Care STDS. 1996 Oct;10(5):316. Unique Identifier : AIDSLINE MED/97229587
New study cites one more reason to control TB [news]: Aids Patient Care STDS. 1996 Oct;10(5):316-7. Unique Identifier : AIDSLINE MED/97229588
Chlamydia screening may reduce pelvic inflammatory disease rates [news]: Aids Patient Care STDS. 1996 Oct;10(5):317. Unique Identifier : AIDSLINE MED/97229589
NIAID chief of STD branch emphasizes importance of developing better diagnostic tests for STDs [news]: Aids Patient Care STDS. 1996 Oct;10(5):317. Unique Identifier : AIDSLINE MED/97229590
HIV/AIDS NetWatch.: Aids Patient Care STDS. 1996 Oct;10(5):318-9. Unique Identifier : AIDSLINE MED/97229591; Makulowich JS; makulow@trainer.com
Recent successes in the antiretroviral therapy of HIV infections [editorial; comment]: Aids Patient Care STDS. 1996 Dec;10(6):330-1. Unique Identifier : AIDSLINE MED/97220418; Laurence J
Commentary: the need for specialization in AIDS clinical care [see comments]: Aids Patient Care STDS. 1996 Dec;10(6):332-3. Unique Identifier : AIDSLINE MED/97220419; Sharp V; HIV Clinical Care Center, Beth Israel HealthCare System, New York, NY,; USA.
Tracheoesophageal fistula in AIDS: stent versus primary repair.: Aids Patient Care STDS. 1996 Dec;10(6):334-5. Unique Identifier : AIDSLINE MED/97220420; Rosario P; Song J; Wittenborn W; Christian F; Departmental of Cardiothoracic Surgery UMDNJ-New Jersey Medical; School, Newark, USA.; Tracheoesophageal fistula arising secondary to Mycobacterium tuberculous infection in AIDS patients is extremely rare. We describe a case with a fistula lesion that initially failed to close using a four-drug antituberculosis regimen. The original lesion closed following placement of an esophageal stent. However, the
Invasive pneumococcal infections in children infected with HIV are not associated with splenic dysfunction.: Aids Patient Care STDS. 1996 Dec;10(6):336-41. Unique Identifier : AIDSLINE MED/97220421; Andiman WA; Simpson J; Holtkamp C; Pearson HA; Department of Pediatrics, Yale University School of Medicine, New; Haven, Connecticut, USA.; OBJECTIVES: Children infected with HIV-1 are more likely to acquire infections associated with the encapsulated bacterial pathogens of childhood than their non-HIV-infected peers. The goal of the current study was to determine what proportion of community-acquired, invasive pneumococcal disease in HIV-infected childre
Renal diseases in HIV-infected patients: pathogenesis, diagnosis, and treatment.: Aids Patient Care STDS. 1996 Dec;10(6):342-8. Unique Identifier : AIDSLINE MED/97220422; Kimmel PL; Department of Medicine, George Washington University Medical Center,; Washington, D.C., USA.; There are several HIV-associated renal disease, the pathogenesis of which is intimately related to the viral infection. Patients demographic characteristics and clinical syndrome analysis may provide clinical clues to the individual renal disease, but in cases where a precise diagnosis is necessary, a renal biopsy is
Thrombotic thrombocytopenic purpura in HIV infection: a report of two cases.: Aids Patient Care STDS. 1996 Dec;10(6):349-52. Unique Identifier : AIDSLINE MED/97220423; Sood R; Rakkar AS; Carmosino L; Mir T; Khan FA; Roswell Park Cancer Institute, Buffalo, NY, USA.; Thrombotic thrombocytopenic purpura (TTP) is a rare but well-described complication of HIV infection, which occurs equally frequently during the early asymptomatic phase of HIV infection and with clinical AIDS. The clinical spectrum varies from a low-grade asymptomatic thrombocytopenia with mild renal insufficiency to
Hypothesis: potential utility of pyridoxal 5'-phosphate (vitamin B6) and levamisole in immune modulation and HIV-1 infection.: Aids Patient Care STDS. 1996 Dec;10(6):353-6. Unique Identifier : AIDSLINE MED/97220424; Salhany JM; Stevenson M; Veterans Administration Medical Center, University of Nebraska Center,; Omaha, USA.
Combination therapies against HIV-1 infection: exploring the concept of combining antiretroviral drug treatments with HIV-1 immune-based therapies in asymptomatic individuals.: Aids Patient Care STDS. 1996 Dec;10(6):357-61. Unique Identifier : AIDSLINE MED/97220425; Ferre F; Moss RB; Daigle AE; Trauger RJ; Richieri SP; Jensen FC; Carlo DJ; AIDS PATIENT CARE and STDs, Larchmont, NY 10538, USA.; The deleterious effect of HIV on the immune system begins at the time of infection. At seroconversion the virologic and immunologic factors that ultimately will dictate the rate of disease progression are believed to be already in place. The concept developed in this paper implies that, to impact significantly on the
Liposomal drug targeting in the treatment of Kaposi's sarcoma.: Aids Patient Care STDS. 1996 Dec;10(6):362-7. Unique Identifier : AIDSLINE MED/97220426; Wernz JC; Division of Oncology, New York University Medical Center, NY 10016,; USA.
Comparing job satisfaction, attitude, and degree of burnout between HIV/AIDS dietitians and general practice dietitians.: Aids Patient Care STDS. 1996 Dec;10(6):368-71. Unique Identifier : AIDSLINE MED/97220427; Kolodny ZB; Chan MM; Department of Nutrition and Food Studies, New York University, New; York, USA.
HIV/AIDS case histories: diagnostic problems. Cryptosporidial colitis.: Aids Patient Care STDS. 1996 Dec;10(6):372. Unique Identifier : AIDSLINE MED/97220428; Godwin JH; Godwin TA; Cornell University Medical College, USA.
Public policy update: an AmFAR report. American Foundation for AIDS Research.: Aids Patient Care STDS. 1996 Dec;10(6):373-4. Unique Identifier : AIDSLINE MED/97220429; Silver J
Combination of two protease inhibitors reduces HIV viral load by 99.9% [news]: Aids Patient Care STDS. 1996 Dec;10(6):375. Unique Identifier : AIDSLINE MED/97220430
Significant inhibitory effects of Hybridon's antisense compound on various HIV-1 replication steps in in vitro tests [news]: Aids Patient Care STDS. 1996 Dec;10(6):375-6. Unique Identifier : AIDSLINE MED/97220431
Nelfinavir study recruiting in eight cities [news]: Aids Patient Care STDS. 1996 Dec;10(6):376. Unique Identifier : AIDSLINE MED/97220433
Yale University begins novel clinical anti-HIV therapy [news]: Aids Patient Care STDS. 1996 Dec;10(6):376. Unique Identifier : AIDSLINE MED/97220432
Multiple-drug antiretroviral therapy reports good HIV suppression in recent seroconverters [news]: Aids Patient Care STDS. 1996 Dec;10(6):376-7. Unique Identifier : AIDSLINE MED/97220434
Compliance and dosage critical in HIV suppression by protease inhibition [news]: Aids Patient Care STDS. 1996 Dec;10(6):377. Unique Identifier : AIDSLINE MED/97220436
Multiple cofactors responsible for reducing vertical transmission with viral load and antiviral therapy as key components [news]: Aids Patient Care STDS. 1996 Dec;10(6):377. Unique Identifier : AIDSLINE MED/97220437
New type of experimental nucleoside (1592) in human trials [news]: Aids Patient Care STDS. 1996 Dec;10(6):377. Unique Identifier : AIDSLINE MED/97220435
Combination trials with 3TC/AZT stopped as clinical benefit shown [news]: Aids Patient Care STDS. 1996 Dec;10(6):378. Unique Identifier : AIDSLINE MED/97220438
FDA alert: protease inhibitors reportedly cause bleeding [news]: Aids Patient Care STDS. 1996 Dec;10(6):378. Unique Identifier : AIDSLINE MED/97220440
Nevirapine approved [news]: Aids Patient Care STDS. 1996 Dec;10(6):378. Unique Identifier : AIDSLINE MED/97220441
Review of expert panel recommendations on antiviral treatment [news]: Aids Patient Care STDS. 1996 Dec;10(6):378. Unique Identifier : AIDSLINE MED/97220439
No resistance to fluconazole with short-term treatment for oral thursh [news]: Aids Patient Care STDS. 1996 Dec;10(6):379. Unique Identifier : AIDSLINE MED/97220443
Prophylactic antibiotic receives speedy FDA approval to reduce MAC disease in advanced HIV [news]: Aids Patient Care STDS. 1996 Dec;10(6):379. Unique Identifier : AIDSLINE MED/97220442
FDA approves human growth hormone for wasting syndrome [news]: Aids Patient Care STDS. 1996 Dec;10(6):379-80. Unique Identifier : AIDSLINE MED/97220444
Flu vaccinations appear safe for HIV patients in NIH-funded study [news]: Aids Patient Care STDS. 1996 Dec;10(6):380. Unique Identifier : AIDSLINE MED/97220445
Vaccines repress HIV in children [news]: Aids Patient Care STDS. 1996 Dec;10(6):381. Unique Identifier : AIDSLINE MED/97220446
NIAID study finds initial intermittent treatment effective for HIV-related TB [news]: Aids Patient Care STDS. 1996 Dec;10(6):381-2. Unique Identifier : AIDSLINE MED/97220447
New data suggest antibiotic clarithromycin is effective in prolonging life of AIDS patients [news]: Aids Patient Care STDS. 1996 Dec;10(6):382-3. Unique Identifier : AIDSLINE MED/97220448
FDA grants marketing clearance of Vistide for the treatment of CMV retinitis [news]: Aids Patient Care STDS. 1996 Dec;10(6):383-4. Unique Identifier : AIDSLINE MED/97220449
Gilead sciences announces statistically significant antiviral activity against hepatitis B virus [news]: Aids Patient Care STDS. 1996 Dec;10(6):384. Unique Identifier : AIDSLINE MED/97220450
Some women still confuse contraception and pregnancy prevention with disease prevention [news]: Aids Patient Care STDS. 1996 Dec;10(6):385. Unique Identifier : AIDSLINE MED/97220451
Targeting HIV prevention message to specific groups was key to San Francisco's success [news]: Aids Patient Care STDS. 1996 Dec;10(6):385-6. Unique Identifier : AIDSLINE MED/97220452
AIDS and telemedicine.: Aids Patient Care STDS. 1996 Dec;10(6):387-8. Unique Identifier : AIDSLINE MED/97220453; Makulowich JS; john@trainer
HIV and the 7-transmembrane domain receptors.: Pathobiology. 1996;64(4):171-9. Unique Identifier : AIDSLINE MED/97183186; Broder CC; Dimitrov DS; Department of Microbiology and Immunology, Uniformed Services; University of the Health Sciences, Bethesda, MD 20814-4799, USA.; The recent discovery of a chemokine receptor, fusin fusin/CXCR-4), as the long-sought human immunodeficiency virus type 1 (HIV-1) coreceptor opened an entirely new field of aquired immunodeficiency syndrome (AIDS) research on mechanisms of viral entry, tropism and pathogenesis. It was soon followed by the identificati
HIV-1 disease association with HLA-DQ antigens in African Americans and Caucasians.: Pathobiology. 1996;64(4):204-8. Unique Identifier : AIDSLINE MED/97183191; Achord AP; Lewis RE; Brackin MN; Henderson H; Cruse JM; Department of Pathology, University of Mississippi Medical Center,; Jackson 39216, USA.; Previously, we have shown that CD4 levels in African Americans infected with human immunodeficiency virus-1 (HIV-1) were lower than those in Caucasians. To determine whether or not HLA type is associated with susceptibility to HIV-1 infection, we demonstrated serologically that HLA-DQ6(1) and HLA-DQ7(3) were associate
Prevalence and impact of chronic childhood conditions in Auckland, New Zealand.: J Paediatr Child Health. 1996 Dec;32(6):484-90. Unique Identifier : AIDSLINE MED/97160260; Vogel AM; Lennon D; Ameratunga SN; Holyoake J; Department of Paediatrics, School of Medicine University of Auckland,; New Zealand.; OBJECTIVE: To establish the prevalence of specific chronic conditions of childhood in the Auckland area and to quantify resource use by these children. METHODOLOGY: Estimates were made from available registry data and published data sources of the population of children with selected chronic conditions resident in the
Highlights from the University of California San Diego Center for AIDS Research.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):117-20. Unique Identifier : AIDSLINE MED/97159680; Wong-Staal F; Department of Biology, University of California, San Diego, La Jolla; 92093-0665, USA.
Mutations within the CD4-CDR-3-like loop allow replication in an immortalized T cell line of HIV type 1 viruses chimeric for envelope glycoproteins containing non-syncytium-inducing V3 loops [letter]: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):121-3. Unique Identifier : AIDSLINE MED/97159681; Signoret N; de Jong J; Goudsmit J; Sattentau QJ
Loss of T cell receptor Vbeta repertoires in HIV type 1-infected SCID-hu mice.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):125-34. Unique Identifier : AIDSLINE MED/97159682; Boldt-Houle DM; Jamieson BD; Aldrovandi GM; Rinaldo CR Jr; Ehrlich GD; Zack JA; Department of Pathology, University of Pittsburgh School of Medicine,; Pennsylvania 15261, USA.; Late-stage HIV-1 disease in humans has been associated with perturbations of the T cell receptor (TCR) Vbeta repertoire. It is not known if the observed loss of certain Vbeta families is attributable directly to HIV-1 infection or whether this is a consequence of multiple opportunistic infections. Putative HIV-1-assoc
VH gene use by HIV type 1-associated lymphoproliferations.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):135-49. Unique Identifier : AIDSLINE MED/97159683; Ng VL; Hurt MH; Herndier BG; Fry KE; McGrath MS; Department of Laboratory Medicine, University of California School of; Medicine, San Francisco, USA.; The pathogenesis of polyclonal HIV-associated lymphomas lacking traditional B cell cofactors (i.e., Epstein-Barr virus [EBV] infection, c-myc translocations) is poorly understood. A multistep pathogenesis model has been proposed in which polyclonal lymphomas represent an earlier stage in HIV-associated lymphomagenesis
V3 loop of human immunodeficiency virus type 1 suppresses interleukin 2-induced T cell growth [published erratum appears in AIDS Res Hum Retroviruses 1997 May 1;13(7):633]: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):151-9. Unique Identifier : AIDSLINE MED/97159684; Sakaida H; Murakami T; Kawamata S; Hattori T; Uchiyama T; Laboratory of AIDS Immunology, Research Center for Immunodeficiency; Virus, Institute for Virus Research, Kyoto University, Japan.; We tested the effect of three linear or two loop peptides derived from the V3 region of the HTLV-III BH10 clone or the SF2 strain of human immunodeficiency virus type 1 on IL-2-driven T cell proliferation. V3-BH10, which consists of 42 amino acids and has a loop structure, suppressed IL-2-driven proliferation of all I
Synergy between human immunodeficiency virus type 1 and Epstein-Barr virus in T lymphoblastoid cell lines.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):161-71. Unique Identifier : AIDSLINE MED/97159685; Zhang RD; Guan M; Park Y; Tawadros R; Yang JY; Gold B; Wu B; Henderson EE; Department of Microbiology and Immunology, Temple University School of; Medicine, Philadelphia, Pennsylvania 19140, USA.; CR2 (CD21), the EBV receptor, was detected on three of four CD4-positive cell lines by indirect fluorescent labeling, and its corresponding mRNA was found by use of the reverse transcription-based polymerase chain reaction. To determine whether CR2 on CD4-positive cells was functional, their ability to be infected by
trans-Activation of the HIV type 1 promoter by 7,8-dihydroneopterin in vitro.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):173-8. Unique Identifier : AIDSLINE MED/97159686; Baier-Bitterlich G; Fuchs D; Zangerle R; Baeuerle PA; Werner ER; Fresser F; Uberall F; Baier G; Wachter H; Institute for Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.; Infection with human immunodeficiency virus type 1 and 2 is associated with elevated concentrations of neopterin, released in large quantities by human macrophages on stimulation with interferon gamma. Evidence has suggested a potential role of neopterin derivatives in oxygen radical-mediated processes. Here we show t
Potent inhibition of replication of primary HIV type 1 isolates in peripheral blood lymphocytes by negatively charged human serum albumins.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):179-85. Unique Identifier : AIDSLINE MED/97159687; Groenink M; Swart PJ; Broersen S; Kuipers M; Meijer DK; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service and Laboratory for; Experimental and Clinical Immunology of the University of Amsterdam.; We previously reported the antiviral capacity of human serum albumin (HSA), which was modified by the introduction of a single Suc-HSA) or two carboxylic groups (Aco-HSA) per lysine residue, yielding strongly negatively charged polypeptides. Here we report the antiviral effect of these modified HSAs on replication of
Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):187-92. Unique Identifier : AIDSLINE MED/97159688; Witvrouw M; Schmit JC; Van Remoortel B; Daelemans D; Este JA; Vandamme AM; Desmyter J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; Sodium valproate (VPA), a simple branched-chain fatty acid that has anticonvulsant activity and is used in the treatment of many forms of epilepsy, has been reported to stimulate human immunodeficiency virus (HIV) type 1 replication in acutely infected CEM and chronically infected U1 cells Chemico-Biological Interacti
Stavudine selectively induces apoptosis in HIV type 1-infected cells.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):193-9. Unique Identifier : AIDSLINE MED/97159689; Hashimoto KI; Tsunoda R; Okamoto M; Shigeta S; Baba M; Department of Microbiology, Fukushima Medical College, Japan.; We evaluated the cytotoxic effects of various human immunodeficiency virus (HIV-1) reverse transcriptase inhibitors zidovudine, didanosine, zalcitabine, stavudine, and nevirapine ) on HIV-1-infected and uninfected T cell lines. Among the compounds, onl
HIV type 1 env gene diversity detected in Taiwan.: AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):201-4. Unique Identifier : AIDSLINE MED/97159690; Chang KS; Lin CI; Chen JH; Shih CH; Lin HC; Lin RY; Twu SC; Salminen MO; Graduate Institute of Clinical Medicine, Chang Gung Medical College,; Taoyuan-Hsien, Taiwan.
Integration of diagnostic imaging in the clinical management of cervical cancer.: J Natl Cancer Inst Monogr. 1996;(21):35-41. Unique Identifier : AIDSLINE MED/97176253; Russell AH; Department of Obstetrics and Gynecology, School of Medicine,; University of California at Davis, USA.; Diagnostic imaging plays multiple roles during the initial assessment, treatment, and surveillance follow-up of patients with cervical cancer. Clarification of pretreatment disease extent aids in understanding prognosis, may influence selection of treatment modalities, and permits outcome comparison between different
Nuclear medicine applications in immunosuppressed patients, AIDS".: Ann Nucl Med. 1996 Nov;10(4):369-73. Unique Identifier : AIDSLINE MED/97159380; Abdel-Dayem HM; New York Medical College, Valhalla, USA.
Usefulness of Ga-67 brain SPECT in patients with CNS malignant lymphoma.: Ann Nucl Med. 1996 Nov;10(4):391-4. Unique Identifier : AIDSLINE MED/97159383; Fujii H; Kosuda S; Suzuki K; Yorino H; Akita S; Negishi H; Nakamura O; Shitara N; Kubo A; Department of Radiology, Tokyo Metropolitan Komagome Hospital, Japan.; The efficacy of Ga-67 SPECT imaging of CNS malignant lymphoma was investigated in 14 studies of 11 patients. As compared with planar images, the SPECT imaging improved the detectability of the focus of CNS malignant lymphoma. All untreated cases showed L/N ratios higher than 3.0. And the L/N ratios also changed accord
UVB irradiation decreases the magnitude of the Th1 response to hapten but does not increase the Th2 response.: Photodermatol Photoimmunol Photomed. 1996 Aug;12(4):145-53. Unique Identifier : AIDSLINE MED/97170261; Saijo S; Kodari E; Kripke ML; Strickland FM; Department of Immunology, University of Texas M.D. Anderson Cancer; Center, Houston 77030, USA.; Exposure of murine skin to low doses of ultraviolet-B (UVB) radiation before sensitization with hapten reduces the ability of antigen presenting cells (APC) in the draining lymph nodes to initiate contact hypersensitivity responses in vivo and results in the induction of hapten-specific suppressor T cells. In the pres
The health and psychosocial status of HIV-seropositive youth in Minnesota.: J Adolesc Health. 1996 Apr;18(4):263-9. Unique Identifier : AIDSLINE MED/97013955; Remafedi G; Lauer T; University of Minnesota Hospital and Clinics, Minneapolis, USA.; OBJECTIVE: To describe the health outcomes and health care utilization of nonhemophiliac adolescents diagnosed with human immunodeficiency virus (HIV) infection. DESIGN: Cross-sectional survey. SUBJECTS: All state residents without hemophilia, 13-21 years of age at the time of HIV infection diagnosis, reported to the
2',3'-dideoxynucleoside triphosphates (ddNTP) and di-2',3'-dideoxynucleoside tetraphosphates (ddNp4ddN) behave differently to the corresponding NTP and Np4N counterparts as substrates of firefly luciferase, dinucleoside tetraphosphatase and phosphodiesterases.: Biochim Biophys Acta. 1997 Mar 15;1334(2-3):191-9. Unique Identifier : AIDSLINE MED/97238494; Sillero MA; Madrid O; Zaera E; Sillero A; Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma; de Madrid, Spain.; 2 ,3 -Dideoxynucleosides (ddN) and their derivatives are currently used as antiretroviral compounds. Their active agents are the corresponding 2 ,3 -dideoxynucleoside triphosphates ddNTPs) generated inside the cell by host kinases. Dinucleoside tetraphosphates (Np4Ns) are molecules of interest in metabolic regulation;
[Pulmonary nocardiosis in a HIV-positive patient (letter)]: Enferm Infecc Microbiol Clin. 1997 Feb;15(2):115-6. Unique Identifier : AIDSLINE MED/97222652; Lorente L; Porcel JM; Barber Y; Rubio M
[Colitis by cytomegalovirus in a patient without human immunodeficiency virus infection (letter)]: Enferm Infecc Microbiol Clin. 1997 Feb;15(2):119-20. Unique Identifier : AIDSLINE MED/97222656; Moro MJ; Oritz E; Bellver MT; Marin G
[Prophylaxis secondary to retinitis by CMV in patients with AIDS: the efficacy of an intermittent schedule of 3 days/week]: Enferm Infecc Microbiol Clin. 1997 Feb;15(2):61-4. Unique Identifier : AIDSLINE MED/97222638; Mallolas J; Gatell JM; Gomez-Sirvent JL; Buira E; Zamora L; Alecrim-Andrade J; Adan A; Morales M; Miro JM; Lonca M; Guelar A; Soriano E; Servicio de Enfermedades Infecciosas, Hospital Clinic, Barcelona.; BACKGROUND: An approach of daily or 5 days per week treatment as maintenance therapy is mandatory among HIV patients with CMV retinitis. We evaluate the efficacy and tolerance of thrice weekly maintenance therapy for CMV retinitis in AIDS patients. METHODS: Sixt
[Infections of the lower respiratory tract in patients with human immunodeficiency virus infection]: Enferm Infecc Microbiol Clin. 1997 Feb;15(2):91-106. Unique Identifier : AIDSLINE MED/97222646; Arzuaga JA; Moreno S; Servicio de Medicina Interna, Hospital de Mendaro, Guipuzcoa.
HIV infection and the kidney.: J Am Soc Nephrol. 1997 Jan;8(1):138-52. Unique Identifier : AIDSLINE MED/97165698; D'Agati V; Appel GB; Department of Medicine, Columbia University College of Physicians and; Surgeons, New York, New York, USA.; HIV-infected patients may present with a variety of patterns of renal involvement. Acute renal failure is common and most often a result of sepsis, hypotension, and nephrotoxic agents. It is potentially avoidable, and support through the period of renal failure may lead to resolution of the renal dysfunction. HIV-asso
A reevaluation of routine electron microscopy in the examination of native renal biopsies.: J Am Soc Nephrol. 1997 Jan;8(1):70-6. Unique Identifier : AIDSLINE MED/97165689; Haas M; Department of Pathology, University of Chicago, IL 60637, USA.; Electron microscopy is routinely utilized in most centers in the evaluation of native renal biopsies. Several studies, primarily from the 1960s and early 1970s, provide justification for its use. Conducted by Siegel et al. (1), the largest study evaluated 213 consecutive renal biopsies and found that electron microsco
Reflecting on the meaning of success [editorial]: J Assoc Nurses AIDS Care. 1996 Nov-Dec;7(6):17-8. Unique Identifier : AIDSLINE MED/97173734; Sowell RL
Body composition in clinically stable men with HIV infection.: J Assoc Nurses AIDS Care. 1996 Nov-Dec;7(6):29-38. Unique Identifier : AIDSLINE MED/97173735; Grady C; Ropka M; Anderson R; Lane HC; Clinical Therapeutics Laboratory, National Institute of Nursing; Research, National Institutes of Health, Bethesda, MD, USA.; Clinically stable HIV-infected men (N = 106) receiving investigational antiretrovirals were recruited. Subjects were divided into three HIV disease severity groups by CD4+ cell count. Standard measures of body composition were assessed, as well as serum measures of visceral protein stores and kilocalorie intake. Group
Training people with HIV disease for involvement in community planning process: Project LEAP. Learning Empowerment Advocacy, Participation.: J Assoc Nurses AIDS Care. 1996 Nov-Dec;7(6):39-47. Unique Identifier : AIDSLINE MED/97173736; Halloran JP; Ross MW; Huffman L; University of Texas School of Public Health, Center for Health; Promotion Research and Development, Houston, USA.; Social and political pressure, as well as public health theory, mandate inclusion of PLWHIV in community planning and policy development processes. Barriers to PLWHIV participation may be cognitive, instrumental, and/or affective. The authors report on development, implementation, and initial evaluation of a pilot pro
Diagnosing HIV dementia: a retrospective analysis.: J Assoc Nurses AIDS Care. 1996 Nov-Dec;7(6):57-66. Unique Identifier : AIDSLINE MED/97173737; Rosenberg DM; McLaulin B; Bennett M; Mathisen K; HIV Outpatient Clinic, Louisiana State University Medical Center, New; Orleans, USA.; The purpose of this study was to determine the criteria by which the diagnosis of HIV dementia was made by providers in a public HIV outpatient clinic and hospital, and to evaluate the extent to which the providers diagnosis confirmed or denied the presence of HIV dementia accordi
Strategies for using chart audit.: J Assoc Nurses AIDS Care. 1996 Nov-Dec;7(6):69-72. Unique Identifier : AIDSLINE MED/97173738; Herman J; College of Nursing, University of South Carolina, Columbia, USA.
Nutritional assessments--when? Who? [letter; comment]: J Assoc Nurses AIDS Care. 1996 Nov-Dec;7(6):77-8. Unique Identifier : AIDSLINE MED/97173739; Wilson LF
Professional nursing education's response to the HIV/AIDS pandemic.: J Assoc Nurses AIDS Care. 1996;7 Suppl 1:15-22. Unique Identifier : AIDSLINE MED/97173741; Corless IB; Nokes KM; MGH Institute of Health Professions, Boston, USA.; Nurse educators have a responsibility to ensure that nursing students learn to respond to the healthcare needs of society even if those needs are evolving as the student s education is occurring. This paper examines the issues and challenges the HIV/AIDS epidemic presents to nurse educators. It then explores ways in w
Patient education for behavior change: help from the Transtheoretical and Harm Reduction models.: J Assoc Nurses AIDS Care. 1996;7 Suppl 1:23-33; discussion 34-40. Unique Identifier : AIDSLINE MED/97173742; Bradley-Springer L; School of Medicine, University of New Mexico, Alburquerque, USA.; Promoting healthy behaviors at all levels of prevention is an important component of nursing care in the HIV epidemic. This paper explores two models that can be used to support behavior change efforts: the Transtheoretical Model, which describes stages in the change process, and the Harm Reduction Model, which offers
Promoting cultural competence in HIV/AIDS care.: J Assoc Nurses AIDS Care. 1996;7 Suppl 1:41-53. Unique Identifier : AIDSLINE MED/97173744; O'Connor BB; Medical College of Pennsylvania, Philadelphia, USA.; The importance of cultural competence in providing health care to a diverse patient population is well-recognized throughout the health professions, though there is as yet no widely accepted set of criteria for establishing and maintaining cultural competence. In HIV/AIDS, where behavioral factors figure so prominentl
HIV education: a challenge to adult learning theory and practice.: J Assoc Nurses AIDS Care. 1996;7 Suppl 1:5-14. Unique Identifier : AIDSLINE MED/97173740; Gallagher DM; New England AIDS Education and Training Center, University of; Massachusetts Medical Center, Worcester, USA.; While there are enormous bodies of literature that separately address adult learning theory and HIV disease education, there is a scarcity of literature that examines the way adult learning theory and education about HIV disease intersect. The author s focus is on successful, creative methods of combining these bodies
The chapter's role in educating ANAC members.: J Assoc Nurses AIDS Care. 1996;7 Suppl 1:55-7. Unique Identifier : AIDSLINE MED/97256342; Melroe H
Resource list for HIV education.: J Assoc Nurses AIDS Care. 1996;7 Suppl 1:59-67. Unique Identifier : AIDSLINE MED/97256343; Powell-Cope GM; College of Nursing, University of South Florida, Tampa.
[Acute renal failure in critically ill elderly patients--a reason to dispense with therapy?]: Langenbecks Arch Chir Suppl Kongressbd. 1996;113:522-3. Unique Identifier : AIDSLINE MED/97214168; Muhl E; Hansen M; Bruch HP; Klinik fur Chirurgie, Medizinische Universitat zu Lubeck.; 846 patients on a surgical intensive care unit (436 patients over 70 years old = group I, 410 patients up to 70 years old = group II) were included in a prospective study of incidence, mortality and reversibility of acute renal failure (ARV). APACHE II-Score showed no differences (17.5 in group I and 15 in group II),
Polysaccharide from Aspalathus linearis with strong anti-HIV activity.: Biosci Biotechnol Biochem. 1997 Feb;61(2):267-71. Unique Identifier : AIDSLINE MED/97212024; Nakano M; Itoh Y; Mizuno T; Nakashima H; Institute for Medical Science of Aging, Aichi Medical University,; Japan. m_nakano@amugw.aichi-med-u.ac.jp; Polysaccharide that has been extracted with 1% sodium carbonate from Rooibos leaves (Aspalathus linearis) showed strong anti-HIV activity. Du-Zhong leaves also showed anti-HIV activity, although lower than the extract of Aspalathus linearis, but Japanese tea leaves and a hot water extract of Aspalathus linearis did no
Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study.: J Neuropsychiatry Clin Neurosci. 1997 Winter;9(1):29-36. Unique Identifier : AIDSLINE MED/97169983; van Dyck CH; McMahon TJ; Rosen MI; O'Malley SS; O'Connor PG; Lin CH; Pearsall HR; Woods SW; Kosten TR; Department of Psychiatry, Yale University School of Medicine, New; Haven, CT 06510, USA.; Other investigators have reported clinical improvement from psychostimulant drugs in patients with HIV-1-related cognitive impairment. However, no previous research has substantiated this claim by using a controlled study design. We examined the efficacy of sustained-release methylphenidate (MSR) in a sample of substa
Subjective complaints versus actual cognitive deficits in predominantly symptomatic HIV-1 seropositive individuals.: J Neuropsychiatry Clin Neurosci. 1997 Winter;9(1):37-44. Unique Identifier : AIDSLINE MED/97169984; Moore LH; van Gorp WG; Hinkin CH; Stern MJ; Swales T; Satz P; Department of Psychiatry and Biobehavioral Sciences, University of; California, Los Angeles, School of Medicine, USA.; The relationship of self-reported cognitive, motor, and affective complaints to actual neuropsychological functioning was explored in a cohort of predominantly symptomatic HIV-1 seropositive individuals. Ninety-two symptomatic HIV-1 infected subjects were questioned about complaints common in HIV infection and were as
Mismatch negativity: an index of subclinical neurological differences in HIV patients during rapid perceptual processing.: J Neuropsychiatry Clin Neurosci. 1997 Winter;9(1):45-54. Unique Identifier : AIDSLINE MED/97169985; Linnville SE; Elliott FS; Cognitive Performance and Psychophysiology Department, Naval Health; Research Center, San Diego, California, USA.; Thirteen asymptomatic HIV-infected (HIV+) and 13 healthy control HIV-) subjects were instructed to detect oddball target tones from among a sequence of nontarget tones delivered rapidly (3 tones/second) in one ear while ignoring a similar sequence delivered simultaneously in the opposite ear. Event-related potential
The human immunodeficiency virus type-1 (HIV-1) Tat protein and Bcl-2 gene expression.: Leuk Lymphoma. 1996 Nov;23(5-6):551-60. Unique Identifier : AIDSLINE MED/97182947; Zauli G; Gibellini D; Institute of Human Anatomy, University of Ferrara, Italy.; Tat protein of human immunodeficiency virus type-1 (HIV-1) plays a central role in viral replication and shows pleiotropic effects on the survival and growth of different cell types. Remarkably, Tat represents the first example of a viral protein, that can also be actively secreted by infected cells and shows a cytoki
Clinical and laboratory features of adult T-cell leukaemia lymphoma in Barbados.: Leuk Lymphoma. 1996 Nov;23(5-6):561-5. Unique Identifier : AIDSLINE MED/97182948; Deardren C; Corbin D; Prussia P; Williams E; Hanshard B; Matutes E; Catovsky D; Department of Medicine, Queen Elizabeth Hospital, St Michael,; Barbados.; We describe the clinical and pathological features of 23 Afro-Caribbean patients with adult T-cell leukaemia/lymphoma admitted to the Queen Elizabeth Hospital, Barbados over a 5 year period. There were 9 males and 14 females, with a median age of 38 years (range 14-84). Twelve ha
PCR. Basic principles and routine practice.: Methods Mol Biol. 1997;67:3-15. Unique Identifier : AIDSLINE MED/97182986; Kolmodin LA; Williams JF; Roche Molecular Systems, Alameda, CA, USA.
Lack of detection of human immunodeficiency virus type 1 in the saliva of infected children and adolescents.: Arch Pediatr Adolesc Med. 1997 Mar;151(3):228-32. Unique Identifier : AIDSLINE MED/97236009; Melvin AJ; Tamura GS; House JK; Hobson AC; Cone RW; Frenkel LM; Burchett S; Department of Pediatrics, Children's Hospital and Medical Center,; Seattle, Wash, USA.; OBJECTIVE: To determine the prevalence of human immunodeficiency virus type 1 (HIV-1) in the saliva of infected children and adolescents. METHODS: Saliva and blood samples were collected from 13 patients (age range, 1-15 years) with HIV-1 infection. Eleven were taking antiretroviral agents. The presence of HIV-1 was d
HIV infection in psychiatric patients: an unlinked anonymous study.: Br J Psychiatry. 1997 Feb;170:181-5. Unique Identifier : AIDSLINE MED/97247384; Ayuso-Mateos JL; Montanes F; Lastra I; Picazo de la Garza J; Ayuso-Gutierrez JL; Department of Psychiatry, University Hospital Marcues ce Valdecilla,; Santander, Spain.; BACKGROUND: Recent surveys suggest that psychiatric patients are at increased risk of being infected with HIV, although very little information is available concerning the seroprevalence of HIV infection among this population outside the US. The aim of this study is to determine the seroprevalence of HIV-I among patie
Vertical transmission of human immunodeficiency virus.: QJM. 1997 Jan;90(1):5-12. Unique Identifier : AIDSLINE MED/97247456; Morrison J; Alp NJ; Nuffield Department of Obstetrics and Gynaecology, John Radcliffe; Hospital, Oxford, UK.; We discuss the interactions between mother and infant that influence the transmission of HIV. Potential routes of infection are identified, and maternal and infant risk factors for transmission are explored. The role of the immune system in controlling HIV infection in the infant is discussed. Finally, preventive meas
[AIDS]: Ryoikibetsu Shokogun Shirizu. 1996;(15):365-72. Unique Identifier : AIDSLINE MED/97200110; Mimaya J; Division of Hematology and Oncology, Shizuoka Children's Hospital.
The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.: Immunity. 1997 Mar;6(3):235-44. Unique Identifier : AIDSLINE MED/97230346; Kinoshita S; Su L; Amano M; Timmerman LA; Kaneshima H; Nolan GP; Department of Molecular Pharmacology, Stanford University School of; Medicine, California 94305, USA.; Clinical deterioration in human immunodeficiency virus type 1 HIV-1) infection is associated with increased levels of viral replication and burden in the peripheral blood and lymphoid organs. T cell activation and ensuing cellular gene activation can be critical for HIV-1 replication. The hypothesis that the nuclear f
The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase.: Immunity. 1997 Mar;6(3):283-91. Unique Identifier : AIDSLINE MED/97230351; Baur AS; Sass G; Laffert B; Willbold D; Cheng-Mayer C; Peterlin BM; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen/Nurnberg, Erlangen, Federal Republic of Germany.; The Nef protein of human and primate lentiviruses is a key factor in HIV/SIV pathogenesis. Here we report that Nef associates with two different kinases, forming a multiprotein complex at the far N-terminus of the viral protein. One of the kinases was identified as Lck, whereas the second protein was found to be a ser
T cell-mediated elimination of B7.2 transgenic B cells.: Immunity. 1997 Mar;6(3):327-39. Unique Identifier : AIDSLINE MED/97230355; Fournier S; Rathmell JC; Goodnow CC; Allison JP; Department of Molecular and Cellular Biology, University of California; at Berkeley, 94720, USA.; Transgenic mice were generated to explore the effects on lymphoid development and immune function of constitutive expression of murine B7.2 on B and T cells. The number of B lymphocytes in primary and secondary lymphoid tissues is normal in B7.2 transgenic lines expressing low levels of B7.2 on B cells, but markedly r
Polydeoxyguanine motifs in a 12-mer phosphorothioate oligodeoxynucleotide augment binding to the v3 loop of HIV-1 gp120 and potency of HIV-1 inhibition independency of G-tetrad formation [published erratum appears in Antisense Nucleic Acid Drug Dev 1997 Apr;7(2):131]: Antisense Nucleic Acid Drug Dev. 1996 Winter;6(4):281-9. Unique Identifier : AIDSLINE MED/97165102; Lederman S; Sullivan G; Benimetskaya L; Lowy I; Land K; Khaled Z; Cleary AM; Yakubov L; Stein CA; Department of Medicine, College of Physicians and Surgeons, Columbia; University, New York, NY 10032, USA.; Phosphorothioate oligodeoxynucleotides belong to a class of polyanions that bind to the third variable domain (v3) of HIV-1 gp120 and inhibit infectivity of a wide variety of HIV-1 isolates. This potent v3 binding of phosphorothioate oligodeoxynucleotides, which is relatively independent of the nucleotide sequence of
Comparison of the antiviral efficacy of ribozymes and antisense RNA directed against bovine leukemia virus rex/tax.: Antisense Nucleic Acid Drug Dev. 1996 Winter;6(4):301-4. Unique Identifier : AIDSLINE MED/97165104; Cantor GH; Stone DM; McElwain TF; Palmer GH; Department of Veterinary Microbiology and Pathology, Washington State; University, Pullman 99164-7040, USA.; Despite the theoretical attraction of ribozymes, which cleave their target RNA, as compared with antisense RNA, which only blocks translation, few studies have assessed the relative efficacy of ribozymes and antisense RNA directed against the identical target sequence. Previously, we described the efficacy of a hammer
Age of Canadians infected with HIV dropping [news]: Can Med Assoc J. 1997 Mar 15;156(6):755. Unique Identifier : AIDSLINE MED/97238036
Africa's emerging AIDS-orphans crisis.: Can Med Assoc J. 1997 Mar 15;156(6):873-5. Unique Identifier : AIDSLINE MED/97238061; Baggaley RC; Needham D; London School of Hygiene and Tropical Medicine.; Although AIDS has had a huge impact around the world, nowhere has its effect been greater than in Africa. In Zambia alone the disease is expected to create 500,000 orphans by the turn of the century. In this article Dr. Rachel Baggaley and Dale Needham examine the huge social probl
[Caregivers of persons infected with HIV]: Can Nurse. 1996 Nov;92(10):43-8. Unique Identifier : AIDSLINE MED/97249937; Banville C; Reidy M; Faculte des sciences infirmieres de I'Universite de Montreal.; This study describes the extent of caregivers knowledge about Quebec men infected with HIV/AIDS, highlights some of the caregivers own health behaviors, assesses their perceptions of their own quality of life, and verifies links between these three variables. The findings are part of a master s thesis, written in 19
Aberrant immunity in the central nervous system in relation to disease progression in HAM/TSP.: Clin Immunol Immunopathol. 1997 Mar;82(3):203-6. Unique Identifier : AIDSLINE MED/97236917; Matsui M; Kuroda Y; Department of Internal Medicine, Saga Medical School, Saga City,; Japan.; The immunological status of the central nervous systems of 19 patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was distinct from that of 6 asymptomatic HTLV-I carriers. Cross-sectional analysis of the time course of disease-related abnormalities in the cerebrospinal fluid (CSF) showed
The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation.: Clin Immunol Immunopathol. 1997 Mar;82(3):207-15. Unique Identifier : AIDSLINE MED/97236918; Yoshida T; Hachimura S; Kaminogawa S; Department of Applied Biological Chemistry, University of Tokyo,; Japan.; The systemic immune response and tolerance induced by oral administration of various doses of bovine alpha s1-casein were examined, focusing on cytokine responses in this study. Spleen cells from mice fed low doses of antigen secreted interferon-gamma and interleukin-2 in response to in vitro antigen stimulation, indi
Characterization of gut-associated lymphoid tissue (GALT) of normal rhesus macaques.: Clin Immunol Immunopathol. 1997 Mar;82(3):230-42. Unique Identifier : AIDSLINE MED/97236921; Veazey RS; Rosenzweig M; Shvetz DE; Pauley DR; DeMaria M; Chalifoux LV; Johnson RP; Lackner AA; Division of Comparative Pathology, New England Regional Primate; Research Center, Harvard Medical School, Southborough, Massachusetts; 01772, USA.; This study characterizes the gut-associated lymphoid tissue GALT) of normal healthy rhesus macaques and compares the percentages of T and B cell subsets to those of systemic lymphoid tissue. Lymphocytes from the systemic lymphoid tissue (spleen, axillary, and inguinal lymph nodes), mesenteric lymph nodes MLN), and int
Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus.: Clin Immunol Immunopathol. 1997 Mar;82(3):243-9. Unique Identifier : AIDSLINE MED/97236922; Togun RA; Resetkova E; Kawai K; Enomoto T; Volpe R; Endocrinology Research Laboratory, Wellesley Central Hospital,; University of Toronto, Ontario, Canada.; Insulin-dependent diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease directed against the insulin-secreting beta cells of the islets of Langerhans of the pancreas. We have previously shown that in organ-specific autoimmune diseases, Graves disease (GD), and IDDM, the antigen that is specific for each of
Derivation of herpesvirus saimiri-transformed CD8+ T cell lines with noncytotoxic anti-HIV activity.: Clin Immunol Immunopathol. 1997 Mar;82(3):274-81. Unique Identifier : AIDSLINE MED/97236926; Mackewicz CE; Orque R; Jung J; Levy JA; Department of Medicine, University of California, San Francisco; 94143-1270, USA.; Herpesvirus saimiri (HVS), strain 488-77, was used to derive continuously growing transformed human CD8+ T cell lines that can suppress HIV replication in CD4+ cells via the production of an antiviral factor(s). Transformed CD8+ cell lines were obtained by HVS infection of peripheral blood mononuclear cells or purifie
T lymphocyte subpopulations in anorexia nervosa and refeeding.: Clin Immunol Immunopathol. 1997 Mar;82(3):282-9. Unique Identifier : AIDSLINE MED/97236927; Mustafa A; Ward A; Treasure J; Peakman M; Department of Immunology, King's College School of Medicine and; Dentistry, London, United Kingdom.; Several studies have addressed the question of the effects of starvation on immune function and changes in lymphocyte subsets. Patients with anorexia nervosa are severely malnourished, but there have been few studies of immune parameters in this group. For this reason, phenotypic markers of T cell function and activat
Soluble factor of transformed B lymphocytes in patients with HIV infection stimulates monocytes to produce PGE2.: Clin Immunol Immunopathol. 1997 Mar;82(3):303-5. Unique Identifier : AIDSLINE MED/97236930; Tarter TH; Cunningham-Rundles S; Laurence J; Koide SS; Department of Urology, University of Southern California School of; Medicine, Los Angeles 90089, USA.; Prostaglandins of the E series (PGE) were measured in the culture supernatants of peripheral blood mono-nuclear cells (PBMC) obtained from patients with human immunodeficiency virus (HIV) infection. Cell culture supernatants from 6 patients with acquired immunodeficiency disease (AIDS) and 11 patients with AIDS-relate
Students' perceptions of their preparation for AIDS patient care: a national survey.: Deans Notes. 1997 Mar;18(4):1-2. Unique Identifier : AIDSLINE MED/97249995; Hurley PM; McGriff EP; College of Nursing, Rutgers, The State University of New Jersey,; Newark, USA.
[Imaging techniques in the assessment of thoracic and abdominal manifestations of AIDS]: Clin Ter. 1996 Sep;147(9):457-64. Unique Identifier : AIDSLINE MED/97122567; Gualdi GF; Ferriano MG; Polettini E; Servizio TC-RM-I Clinica Medica, Universita degli Studi di Roma La; Sapienza.; In this report we take into consideration pulmonary and abdominal manifestation of AIDS. We assess the role of imaging in diagnosis and checking the spread of these diseases, particularly the role of US and TC.
HIV confidentiality and medical records. State of Connecticut Department of Public Health.: Conn Med. 1997 Feb;61(2):113. Unique Identifier : AIDSLINE MED/97218777
[A new problem: multiresistant fungi (news)]: Dtsch Med Wochenschr. 1997 Mar 14;122(11):A9. Unique Identifier : AIDSLINE MED/97247036; Wehr A
[Early antiretroviral combination therapy--standard today and tomorrow]: Dtsch Med Wochenschr. 1997 Mar 14;122(11 Suppl):1-4. Unique Identifier : AIDSLINE MED/97247035
Activated cytotoxic lymphocytes in lymph nodes from human immunodeficiency virus (HIV) 1-infected patients: a light and electronmicroscopic study.: Histopathology. 1997 Jan;30(1):31-40. Unique Identifier : AIDSLINE MED/97175981; Sunila I; Vaccarezza M; Pantaleo G; Fauci AS; Orenstein JM; George Washington University, Medical Center, Department of Pathology,; Washington, DC 20037, USA.; Persistent generalized lymphadenopathy often develops during HIV-infection. It is characterized by follicular hyperplasia which progresses over time to follicular involution and finally lymphocyte depletion. To determine whether activated cytotoxic T cells (CD8+) are present in the hyperplastic germinal centres, light
Influence of sexual abuse on HIV-related attitudes and behaviors in adolescent psychiatric inpatients.: J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):316-22. Unique Identifier : AIDSLINE MED/97208316; Brown LK; Kessel SM; Lourie KJ; Ford HH; Lipsitt LP; Rhode Island Hospital, Brown University School of Medicine,; Providence, USA.; OBJECTIVE: To investigate the associations between sexual abuse and human immunodeficiency virus (HIV)-related attitudes and behaviors of adolescents with a psychiatric disorder. METHOD: HIV-related knowledge, attitudes, and behaviors were examined by self-report assessment of adolescents admitted to a psychiatric hos
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.: J Biol Chem. 1997 Mar 7;272(10):6214-9. Unique Identifier : AIDSLINE MED/97197786; Fusaki N; Iwamatsu A; Iwashima M; Fujisawa Ji; Department of Microbiology, Kansai Medical University, 10-15; Fumizono-cho, Moriguchi-shi, Osaka 570, Japan.; The Src family protein-tyrosine kinase, Fyn, is associated with the T cell receptor (TCR) and plays an important role in TCR-mediated signaling. We found that a human T cell leukemia virus type 1-infected T cell line, Hayai, overexpressed Fyn. To identify the molecules downstream of Fyn, we analyzed the tyrosine phosp
Kinetics analysis of consecutive HIV proteolytic cleavages of the Gag-Pol polyprotein.: J Biol Chem. 1997 Mar 7;272(10):6348-53. Unique Identifier : AIDSLINE MED/97197805; Rasnick D; Arris Pharmaceutical Corporation, South San Francisco, California; 94080, USA. rasnick@mindspring.com; The ordered, sequential cleavages of the Gag-Pol polyprotein by human immunodeficiency virus (HIV) protease present the virus with severe limitations on viable mutations of the enzyme. An extension of the method of Kuchel et al. (Kuchel, P. W., Nichol, L. W., and Jeffrey, P. D. (1974) J. Theor. Biol. 48, 39-49) for th
HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.: J Biol Chem. 1997 Mar 14;272(11):6854-7. Unique Identifier : AIDSLINE MED/97207235; Farzan M; Choe H; Martin KA; Sun Y; Sidelko M; Mackay CR; Gerard NP; Sodroski J; Gerard C; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Department of Pathology, Harvard Medical School, Boston, Massachusetts; 02115, USA.; The human immunodeficiency virus type 1 (HIV-1) requires the presence of specific chemokine receptors in addition to CD4 to enter its target cell. The chemokine receptor CCR5 is used by macrophage-tropic strains of HIV-1, which predominate during the asymptomatic stages of infection. Here we investigate whether the ab
Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.: J Biol Chem. 1997 Mar 14;272(11):6951-8. Unique Identifier : AIDSLINE MED/97207248; Garcia-Martinez LF; Ivanov D; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas, Texas 75235-8594, USA.; The HIV-1 (human immunodeficiency virus type 1) and HIV-2 Tat proteins increase the level of transcription from their corresponding long terminal repeats. Tat activates transcription likely by interaction with components of the transcriptional initiation and elongation complexes during different stages of the transcri
Pseudopeptide TASP inhibitors of HIV entry bind specifically to a 95-kDa cell surface protein.: J Biol Chem. 1997 Mar 14;272(11):7159-66. Unique Identifier : AIDSLINE MED/97207276; Callebaut C; Jacotot E; Krust B; Guichard G; Blanco J; Valenzuela A; Svab J; Muller S; Briand JP; Hovanessian AG; Unite de Virologie et Immunologie Cellulaire, URA 1157 CNRS, Institut; Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France.; The template assembled synthetic peptide constructs (TASP), pentavalently presenting the tripeptide KPR or RPK, are potent and specific inhibitors of human immunodeficiency virus (HIV) infection by preventing viral entry into permissive cells. Here the 5[KPsi(CH2N)PR]-TASP construct, Psi(CH2N) for reduced peptide bond
Synthetic soluble analogs of galactosylceramide (GalCer) bind to the V3 domain of HIV-1 gp120 and inhibit HIV-1-induced fusion and entry.: J Biol Chem. 1997 Mar 14;272(11):7245-52. Unique Identifier : AIDSLINE MED/97207285; Fantini J; Hammache D; Delezay O; Yahi N; Andre-Barres C; Rico-Lattes I; Lattes A; Laboratoire de Biochimie et Biologie de la Nutrition, URA-CNRS 1820,; Faculte des Sciences St Jerome, Marseille cedex 20, France.; Galactosylceramide (GalCer) is an alternative receptor allowing human immunodeficiency virus (HIV)-1 entry into CD4-negative cells of neural and colonic origin. Several lines of evidence suggest that this glycosphingolipid recognizes the V3 region of HIV-1 surface envelope glycoprotein gp120. Since the V3 loop plays a
Differential tolerance to DNA polymerization by HIV-1 reverse transcriptase on N6 adenine C10R and C10S benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide-adducted templates.: J Biol Chem. 1997 Feb 28;272(9):5805-13. Unique Identifier : AIDSLINE MED/97190313; Chary P; Harris CM; Harris TM; Lloyd RS; Center for Molecular Science, The University of Texas Medical Branch,; Galveston, Texas 77555, USA.; To determine the effect of various stereoisomers of benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide (BPDE) on translesion bypass by human immunodeficiency virus-1 reverse transcriptase and its alpha-helix H mutants, six 33-mer templates were constructed bearing site- and stereospecific adducts. This in vitro model system
Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines.: J Biol Chem. 1997 Feb 28;272(9):5814-20. Unique Identifier : AIDSLINE MED/97190314; Rivas CI; Vera JC; Guaiquil VH; Velasquez FV; Borquez-Ojeda OA; Carcamo JG; Concha II; Golde DW; Program in Molecular Pharmacology and Therapeutics, Memorial; Sloan-Kettering Cancer Center, New York, New York 10021, USA.; Vitamin C (ascorbic acid) is required for normal host defense and functions importantly in cellular redox systems. To define the interrelationship between human immunodeficiency virus (HIV) infection and vitamin C flux at the cellular level, we analyzed vitamin C uptake and its effects on virus production and cellular
Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8-NH2-dGTP by reverse transcriptases and mammalian DNA polymerases.: J Biol Chem. 1997 Feb 28;272(9):5892-8. Unique Identifier : AIDSLINE MED/97190325; Kamath-Loeb AS; Hizi A; Kasai H; Loeb LA; Department of Pathology, University of Washington, Seattle, Washington; 98195, USA.; We have measured the efficiencies of utilization of 8-oxo-dGTP and 8-NH2-dGTP by human immunodeficiency virus type 1 and murine leukemia virus reverse transcriptases and compared them to those of DNA polymerases alpha and beta. Initially, we carried out primer extension reactions in the presence of dGTP or a dGTP anal
V3 loop core region serotyping of HIV-1 infected patients using the FHV epitope presenting system.: J Virol Methods. 1997 Jan;63(1-2):121-7. Unique Identifier : AIDSLINE MED/97167664; Schiappacassi M; Buratti E; D'Agaro P; Ciani L; Scodeller ES; Tisminetzky SG; Baralle FE; International Centre for Genetic Engineering and Biotechnology ICGEB),; Trieste, Italy.; We have reported recently a new epitope presenting system based on the Flock House Virus (FHV) capsid protein. The HIV-1 V3 loop core sequence IGPGRAF was inserted in different sites of this carrier molecule. Immunoreactivity experiments and molecular modelling consistently showed that the most reactive recombinant pr
Detection of human immunodeficiency virus type 1 and type 2 antibodies by a new automated microparticle immunoassay AxSYM HIV-1/HIV-2.: J Virol Methods. 1997 Jan;63(1-2):137-43. Unique Identifier : AIDSLINE MED/97167666; Weber B; Behrens N; Doerr HW; Institut fur Medizinische Virologie, Zentrum der Hygiene,; Universitatskliniken Frankfurt a. M., Germany.; A new automated microparticle enzyme immunoassay (MEIA) for the AxSYM instrument developed recently by Abbott Laboratories was compared with two established assays, i.e. HIV-1/HIV-2 3rd Gen. Plus EIA (Abbott, Delkenheim, FRG) and Wellcozyme HIV 1 + 2 Murex Diagnostics, Dartford, E
Amplification, cloning and sequencing of the sigmaC-encoded gene of avian reovirus [published erratum appears in J Virol Methods 1997 May;65(2):318]: J Virol Methods. 1997 Jan;63(1-2):203-8. Unique Identifier : AIDSLINE MED/97167673; Liu HJ; Giambrone JJ; Department of Poultry Science, Alabama Agriculture Experiment Station,; Auburn University, 36849-5416, USA.; The sigmaC-encoding cDNA of avian reovirus (ARV) 1733 strain was amplified, cloned and sequenced using double nested polymerase chain reaction (PCR). The ARV sigmaC protein is a minor component of the outer capsid that induces type-specific neutralization antibodies. Four overlapping sigmaC-encoding cDNA fragments wer
Detection of Maedi-Visna virus antibodies using a single fusion transmembrane-core p25 recombinant protein ELISA and a modified receiver-operating characteristic analysis to determine cut-off values.: J Virol Methods. 1997 Jan;63(1-2):47-56. Unique Identifier : AIDSLINE MED/97167657; Boshoff CH; Dungu B; Williams R; Vorster J; Conradie JD; Verwoerd DW; York DF; Onderstepoort Veterinary Institute, South Africa.; The core p25 and transmembrane (TM) genes of Maedi-Visna virus MVV) were cloned individually into the pGEX-2T expression vector. Both proteins were expressed as a combined fusion protein in frame with glutathione S-transferase (GST). The purified recombinant antigens (GST-TM and GST-TM-p25) were used to develop a MVV
Development of a quantitative competitive polymerase chain reaction for human herpesvirus 8.: J Virol Methods. 1997 Feb;64(1):19-26. Unique Identifier : AIDSLINE MED/97181365; Lock MJ; Griffiths PD; Emery VC; Department of Virology, Royal Free Hospital School of Medicine,; University of London, UK.; A quantitative competitive polymerase chain reaction (PCR) assay for human herpesvirus 8 (HHV8) was developed. The assay uses a competitive internal control sequence which differs from the wild type sequence by the presence of an EcoRI restriction endonuclease site. The quantitative method was validated by co-amplifyi
Two PBMC-based neutralization assays depict low reactivity of both anti-V3 monoclonal antibodies and immune sera against HIV-1 primary isolates.: J Virol Methods. 1997 Feb;64(1):81-93. Unique Identifier : AIDSLINE MED/97181372; Candotti D; Rosenheim M; Huraux JM; Agut H; Laboratoire de Virologie, CNRS EP 57, CERVI, Hopital de la; Pitie-Salpetriere, Paris, France.; The neutralizing activity of anti-V3 monoclonal antibodies (MAbs) and anti-HIV-1 immune sera was tested against HIV-1 laboratory strains and African primary isolates. Neutralization was investigated in Phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cell (PBMC) cultures by means of two distinct viral
Pharmacokinetics of recombinant human granulocyte-macrophage colony-stimulating factor: the effects of zidovudine.: J Clin Pharmacol. 1996 Dec;36(12):1107-13. Unique Identifier : AIDSLINE MED/97165605; Aweeka FT; Kwong M; Mak M; al-Uzri A; Affrime M; Cutler D; Kahn J; Gambertoglio JG; Department of Clinical Pharmacy, University of California, San; Francisco 94143-0622, USA.; Recombinant human granulocyte-macrophage colony-stimulating factor (rHu GM-CSF) enhances bone marrow production of and stimulates granulocytes, macrophages, and eosinophils. Granulocyte-macrophage colony-stimulating factor may be used concomitantly with zidovudine in human immunodeficiency virus HIV)-positive patients
Comparisons of oxidative metabolism and reductive capacity in sulfonamide-tolerant and -intolerant patients with human immunodeficiency virus.: J Clin Pharmacol. 1996 Dec;36(12):1149-53. Unique Identifier : AIDSLINE MED/97165611; Lehmann DF; Holohan PD; Blair DC; Department of Medicine, State University of New York Health Science; Center at Syracuse, USA.; Hypersensitivity reactions to trimethoprim/sulfamethoxazole occur with a high frequency in human immunodeficiency virus HIV)-infected patients. This study tested whether differences in oxidative metabolism and plasma reductive capacity correlate with sulfonamide intolerance in patients with HIV. Eighteen stable outpat
Blastomycosis-like pyoderma in a man with AIDS.: J Am Acad Dermatol. 1997 Apr;36(4):633-4. Unique Identifier : AIDSLINE MED/97246517; Crowley JJ; Kim YH; Department of Dermatology, Stanford University School of Medicine,; Palo Alto, California 94304, USA.
Transmission and establishment of a persistent infection of Enterocytozoon bieneusi, derived from a human with AIDS, in simian immunodeficiency virus-infected rhesus monkeys.: J Infect Dis. 1997 Apr;175(4):1016-20. Unique Identifier : AIDSLINE MED/97240713; Tzipori S; Carville A; Widmer G; Kotler D; Mansfield K; Lackner A; Division of Infectious Diseases, Tufts University School of Veterinary; Medicine, North Grafton, Massachusetts 01536, USA.; Enterocytozoon bieneusi is closely linked with chronic diarrhea and wasting in AIDS. Although reported >10 years ago, little is known about the infection and the disease it induces in humans. Duodenal E. bieneusi spores from an AIDS patient were orally transmitted to 2 simian immunodeficiency virus-infected rhesus mon
High seroprevalence of Encephalitozoon species in immunocompetent subjects.: J Infect Dis. 1997 Apr;175(4):1020-4. Unique Identifier : AIDSLINE MED/97240714; van Gool T; Vetter JC; Weinmayr B; Van Dam A; Derouin F; Dankert J; Department of Medical Microbiology, Academic Medical Center,; University of Amsterdam, Netherlands.; Encephalitozoon species are important pathogens in human immunodeficiency virus-infected patients. However, in immunocompetent persons, little is known about Encephalitozoon infections, mainly because of the lack of reliable diagnostic tests. To improve diagnosis, three serologic techniques that use Encephalitozoon in
Parenteral and sexual transmission of GB virus C and hepatitis C virus among human immunodeficiency virus-positive patients [letter]: J Infect Dis. 1997 Apr;175(4):1025-6. Unique Identifier : AIDSLINE MED/97240716; Fiordalisi G; Bettinardi A; Zanella I; Stellini R; Paraninfo G; Cadeo G; Primi D
Neutralization of a clade B primary isolate by sera from human immunodeficiency virus-uninfected recipients of candidate AIDS vaccines.: J Infect Dis. 1997 Apr;175(4):764-74. Unique Identifier : AIDSLINE MED/97240668; Zolla-Pazner S; Alving C; Belshe R; Berman P; Burda S; Chigurupati P; Clements ML; Duliege AM; Excler JL; Hioe C; Kahn J; McElrath MJ; Sharpe S; Sinangil F; Steimer K; Walker MC; Wassef N; Xu S; VA Medical Center, New York, NY 10010, USA.; The inability of antibodies induced by experimental human immunodeficiency virus type 1 (HIV-1) vaccines to neutralize HIV-1 primary isolates may be due to a failure to elicit such antibodies, antigenic differences between the vaccine and the strains tested, insensitivity of the assays used, or to a combination of fac
Is there a general tendency for CD4 lymphocyte decline to speed up during human immunodeficiency virus infection? Evidence from the Italian Seroconversion Study.: J Infect Dis. 1997 Apr;175(4):775-80. Unique Identifier : AIDSLINE MED/97240669; Lepri AC; Sabin CA; Pezzotti P; England PD; Phillips AN; Rezza G; Department of Primary Care and Population Sciences, Royal Free; Hospital, London, United Kingdom.; It has been suggested that the rate of CD4 cell decline accelerates in parallel with decreasing numbers of cells; however, the statistical literature suggests the opposite. CD4 cells were counted about every 6 months in a cohort of 1264 human immunodeficiency virus-infected subjects (the Italian Seroconversion Study c
Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons.: J Infect Dis. 1997 Apr;175(4):781-9. Unique Identifier : AIDSLINE MED/97240670; Davey RT Jr; Chaitt DG; Piscitelli SC; Wells M; Kovacs JA; Walker RE; Falloon J; Polis MA; Metcalf JA; Masur H; Fyfe G; Lane HC; National Institute of Allergy and Infectious Diseases, Critical Care; Medicine Department, National Institutes of Health, Bethesda, Maryland; 20892-1880, USA.; The safety and efficacy were assessed of 5-day cycles of subcutaneous (sc) interleukin-2 ( IL-2 ) every 8 weeks in human immunodeficiency virus type 1-infected outpatients with >200 CD4 cells/mm3. Immunologic, virologic, and toxicity parameters were measured in 18 patien
The interleukin-2 fusion protein, DAB389IL-2, inhibits the development of infectious virus in human immunodeficiency virus type 1-infected human peripheral blood mononuclear cells.: J Infect Dis. 1997 Apr;175(4):790-4. Unique Identifier : AIDSLINE MED/97240671; Zhang LJ; Waters CA; Poisson LR; Estis LF; Crumpacker CS; Division of Infectious Diseases, Beth Israel Hospital, Boston,; Massachusetts 02215, USA.; DAB389IL-2 is a genetically engineered fusion protein that reduces human immunodeficiency virus type 1 (HIV-1) replication in activated, interleukin (IL)-2 receptor (IL-2R)-expressing human peripheral blood mononuclear cells (PBMC). The level of infectious virus released by cultured PBMC after treatment with DAB389IL-
Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women.: J Infect Dis. 1997 Apr;175(4):795-800. Unique Identifier : AIDSLINE MED/97240672; Evans JS; Nims T; Cooley J; Bradley W; Jagodzinski L; Zhou S; Melcher GP; Burke DS; Vahey M; Department of Infectious Diseases, Wilford Hall Medical Center,; Lackland Air Force Base, Texas 78236-5300, USA.; The fundamental clinical, viral, and immunologic features of early-stage human immunodeficiency virus type 1 (HIV-1) disease were examined in a seroprevalent cohort of 28 men and 14 women assessed longitudinally at three equally dispersed time points over a mean of 43 months. There were no gender differences in the re
A pilot study of hydroxyurea among patients with advanced human immunodeficiency virus (HIV) disease receiving chronic didanosine therapy: Canadian HIV trials network protocol 080.: J Infect Dis. 1997 Apr;175(4):801-6. Unique Identifier : AIDSLINE MED/97240673; Montaner JS; Zala C; Conway B; Raboud J; Patenaude P; Rae S; O'Shaughnessy MV; Schechter MT; Department of Medicine, University of British Columbia, Vancouver,; Canada.; To assess the in vivo short-term antiretroviral effect of hydroxyurea in human immunodeficiency virus (HIV)-infected persons chronically treated with didanosine (ddI), 26 patients with CD4 cell counts between 100 and 350 were enrolled in a 12-week, open-label pilot study and randomly assigned to receive 500 or 1000 mg
Cytokines enhance neutrophils from human immunodeficiency virus-negative donors and AIDS patients to inhibit the growth of Mycobacterium avium in vitro.: J Infect Dis. 1997 Apr;175(4):891-900. Unique Identifier : AIDSLINE MED/97240686; Newman GW; Guarnaccia JR; Remold HG; Kazanjian PH Jr; Department of Rheumatology/Immunology, Brigham & Women's Hospital,; Harvard Medical School, Boston, Massachusetts, USA.; Mycobacterium avium is one of the most prevalent opportunistic infections in AIDS patients, and neither prophylaxis nor treatment against M. avium is effective. To evaluate host defense mechanisms against mycobacterial infections, studies investigated whether neutrophils from AIDS patients could inhibit the growth of
High incidence of Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus in tumor lesions and peripheral blood mononuclear cells from patients with Kaposi's sarcoma in Uganda.: J Infect Dis. 1997 Apr;175(4):947-50. Unique Identifier : AIDSLINE MED/97240696; Purvis SF; Katongole-Mbidde E; Johnson JL; Leonard DG; Byabazaire N; Luckey C; Schick HE; Wallis R; Elmets CA; Giam CZ; Department of Medicine, Case Western Reserve University School of; Medicine, and University Hospitals of Cleveland, Ohio, USA.; With the advent of AIDS, Kaposi s sarcoma (KS) has become one of the leading malignancies in sub-Saharan Africa. Recently, DNA sequences from a new human herpesvirus called KS-associated herpesvirus (KSHV) or human herpesvirus type 8 have been found in KS tumor lesions in high frequency. Analyses of tumor lesions from
Human immunodeficiency virus infection and AIDS in a person with negative serology.: J Infect Dis. 1997 Apr;175(4):955-9. Unique Identifier : AIDSLINE MED/97240698; Montagnier L; Brenner C; Chamaret S; Guetard D; Blanchard A; de Saint Martin J; Poveda JD; Pialoux G; Gougeon ML; Department SIDA et Retrovirus, Hopital Pasteur, Paris, France.; A 38-year-old woman resident of Ivory Coast died of AIDS, while remaining human immunodeficiency virus (HIV)-seronegative. She had been regularly tested because her husband was HIV-seropositive. The subject s lack of specific antibodies was assessed using commercial tests and
Detection of infection with human immunodeficiency virus type 1 before seroconversion: correlation with clinical symptoms and outcome.: J Infect Dis. 1997 Apr;175(4):959-62. Unique Identifier : AIDSLINE MED/97240699; Phair JP; Margolick JB; Jacobson LP; Phillips J; Rinaldo C; Kaslow R; Chu C; Giorgi JV; Henrard D; Department of Medicine, Northwestern University School of Medicine,; and Howard Brown Health Center, Chicago, Illinois, USA.; Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last seronegative visit. A
Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage.: J Infect Dis. 1997 Apr;175(4):963-6. Unique Identifier : AIDSLINE MED/97240700; Brew BJ; Pemberton L; Cunningham P; Law MG; Department of HIV Medicine, St. Vincent's Hospital, Sydney, Australia.; The relationship between the presence and severity of AIDS dementia complex (ADC) and the levels of human immunodeficiency virus type 1 (HIV-1) RNA in cerebrospinal fluid (CSF) were assessed. Nineteen patients with ADC (stages 1-3), 6 without ADC group 1), and 10 (group 2) without
High-dose nevirapine in previously untreated human immunodeficiency virus type 1-infected persons does not result in sustained suppression of viral replication.: J Infect Dis. 1997 Apr;175(4):966-70. Unique Identifier : AIDSLINE MED/97240701; de Jong MD; Vella S; Carr A; Boucher CA; Imrie A; French M; Hoy J; Sorice S; Pauluzzi S; Chiodo F; Weverling GJ; van der Ende ME; Frissen PJ; Weigel HM; Kauffmann RH; Lange JM; Yoon R; Moroni M; Hoenderdos E; Leitz G; Cooper DA; Hall D; Reiss P; National AIDS Therapy Evaluation Centre, Department of Infectious; Diseases, University of Amsterdam, Netherlands.; High-dose nevirapine treatment has been reported to confer sustained antiretroviral effects, despite a rapid development of resistance. The use of this strategy was evaluated in 20 previously untreated human immunodeficiency virus type 1 (HIV-1) p24 a
Analysis of the maternal components of the AIDS clinical trial group 076 zidovudine regimen in the prevention of mother-to-infant transmission of human immunodeficiency virus type 1.: J Infect Dis. 1997 Apr;175(4):971-4. Unique Identifier : AIDSLINE MED/97240702; Frenkel LM; Cowles MK; Shapiro DE; Melvin AJ; Watts DH; McLellan C; Mohan K; Murante B; Burchett S; Bryson YJ; O'Sullivan MJ; Mitchell C; Landers D; University of Rochester, New York, USA.; To gain insight into the protective effects of the three components of the zidovudine regimen used in AIDS Clinical Trial Group (ACTG) 076 on mother-to-infant transmission of human immunodeficiency virus (HIV) type 1, 188 zidovudine-treated women and their untreated infants from five HIV-1 obstetric centers were retro
Responsiveness of human immunodeficiency virus type 1-infected Kenyan women with or without prior pneumococcal disease to pneumococcal vaccine.: J Infect Dis. 1997 Apr;175(4):975-8. Unique Identifier : AIDSLINE MED/97240703; Janoff EN; Fasching C; Ojoo JC; O'Brien J; Gilks CF; Department of Medicine, Veterans Affairs Medical Center, University of; Minnesota School of Medicine, Minneapolis 55417, USA.; In East Africa, Streptococcus pneumoniae is a common and serious, but potentially preventable, human immunodeficiency virus type 1 HIV-1)-associated pathogen. For 54 HIV-1-infected women, baseline levels of capsule-specific antibody to 2 of 4 pneumococcal serotypes were lower than levels in 15 seronegative women (P
Sex-ratio patterns of AIDS patients in Thailand.: J Med Assoc Thai. 1997 Jan;80(1):34-46. Unique Identifier : AIDSLINE MED/97233912; Rerks-Ngarm S; Department of Communicable Diseases Control, Ministry of Public; Health, Nonthaburi, Thailand.; The summary report of AIDS cases in Thailand , as of 31 July 1996, was reviewed for the information on male-to female sex-ratio. The ratios were recalculated for different risk-factors and for different age-groups annually and cumulatively. The male-to-female ratios calculated for
Risk behaviours and comprehension among intravenous drug users volunteered for HIV vaccine trial.: J Med Assoc Thai. 1997 Jan;80(1):47-50. Unique Identifier : AIDSLINE MED/97233913; Pitisuttithum P; Migasena S; Laothai A; Suntharasamai P; Kumpong C; Vanichseni S; Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol; University, Bangkok, Thailand.; Out of 91 volunteers enrolled for the HIV vaccine trial, only 33 volunteers were eligible for vaccination. Of 33 volunteers recruited, 59 per cent of them had incomes of more than 5,000 Baht/ month. The median duration of drug addicts was 15 years range 1-26 years) and 42 per cent never used condoms during sexual inte
AIDS dementia complex in the Italian National AIDS Registry: temporal trends (1987-93) and differential incidence according to mode of transmission of HIV-1 infection.: J Neurol Sci. 1996 Dec;144(1-2):107-13. Unique Identifier : AIDSLINE MED/97147206; Chiesi A; Seeber AC; Dally LG; Floridia M; Rezza G; Vella S; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.; OBJECTIVES: To investigate the occurrence of AIDS dementia complex (ADC) in Italy and its incidence over time, examining possible correlations between this condition and some demographic and immunological variables. DESIGN: Inception cohort. Data
HIV testing in the home [news]: J Community Health Nurs. 1997;14(1):67. Unique Identifier : AIDSLINE MED/97189812
Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells.: J Pharmacol Exp Ther. 1997 Mar;280(3):1228-34. Unique Identifier : AIDSLINE MED/97219933; Cui L; Locatelli L; Xie MY; Sommadossi JP; Department of Pharmacology and Toxicology, University of Alabama at; Birmingham 35294, USA.; The effects of several anti-human immunodeficiency virus nucleoside analogs were examined on neurite regeneration and mitochondrial DNA (mtDNA) synthesis in nerve growth factor-primed PC-12 cells. Under pharmacologically relevant concentrations, the exposure of cells to 2 ,3 -dideoxyinosine (ddI), 2 ,3 -dideoxycytidin
Pharmacokinetics and distribution of a 33P-labeled anti-human immunodeficiency virus oligonucleotide (AR177) after single- and multiple-dose intravenous administration to rats.: J Pharmacol Exp Ther. 1997 Mar;280(3):1480-8. Unique Identifier : AIDSLINE MED/97219963; Wallace TL; Bazemore SA; Holm K; Markham PM; Shea JP; Chaudhary N; Cossum PA; Aronex Pharmaceuticals, Inc., The Woodlands, Texas 77381, USA.; AR177 is a 17-mer oligonucleotide that has anti-human immunodeficiency virus activity in vitro. The disposition of internally labeled 33P-AR177 was studied after the tail vein injection of single and multiple doses (0.7 mg/kg) to rats. After a single dose, the terminal half-life of AR177 in the blood and plasma was 36
Is there a Th2 bias in human pregnancy?: J Reprod Immunol. 1996 Dec;32(2):101-4. Unique Identifier : AIDSLINE MED/97176241; Vince GS; Johnson PM; Department of Immunology, University of Liverpool, UK.
There is a bias against type 1 (inflammatory) cytokine expression and function in pregnancy.: J Reprod Immunol. 1996 Dec;32(2):105-10. Unique Identifier : AIDSLINE MED/97176242; Guilbert LJ; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada.
DNA curvature controls termination of plus strand DNA synthesis at the centre of HIV-1 genome.: J Mol Biol. 1997 Feb 28;266(3):507-24. Unique Identifier : AIDSLINE MED/97220232; Lavigne M; Roux P; Buc H; Schaeffer F; Unite de Physicochimie des Macromolecules Biologiques (CNRS URA 1149),; Institut Pasteur, Paris, France.; In vivo and in vitro, reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1) terminates plus strand synthesis at the centre of the viral genome. The central termination sequence (CTS) contains curved DNA fragments located upstream of each terminator site. Two different models, relying either on th
NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein.: J Mol Biol. 1997 Mar 7;266(4):649-55. Unique Identifier : AIDSLINE MED/97226665; Jelinek R; Terry TD; Gesell JJ; Malik P; Perham RN; Opella SJ; Department of Chemistry University of Pennsylvania, Philadelphia; 19104, USA.; An NMR approach for structure determination of short peptides displayed on the surface of filamentous bacteriophage virions is demonstrated using the hexapeptide GPGRAF that constitutes the principal neutralizing determinant of HIV-1. This peptide was inserted near the N terminus of the major coat protein of bacteriop
CDC and AAO offer guidance on safe surgery.: J Ophthalmic Nurs Technol. 1996 Nov-Dec;15(6):257-8. Unique Identifier : AIDSLINE MED/97250071; Nataloni R; 1. The Centers for Disease Control and Prevention recommends that all health care workers should routinely use appropriate barrier precautions to prevent skin and mucous membrane exposure when contact with blood or other body fluids is anticipated. 2. Although HIV may be found in the tears, conjunctiva, cornea, and co
Thioredoxin/adult T-cell leukemia-derived factor (ADF) and redox regulation.: J Toxicol Sci. 1996 Dec;21(5):285-7. Unique Identifier : AIDSLINE MED/97187583; Sasada T; Sono H; Yodoi J; Department of Biological Responses, Kyoto University, Japan.
The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl.: J Virol. 1997 Apr;71(4):2615-20. Unique Identifier : AIDSLINE MED/97213924; Dupraz P; Rebai N; Klein SJ; Beaulieu N; Jolicoeur P; Laboratory of Molecular Biology, Clinical Research Institute of; Montreal, Quebec, Canada.; The Pr60gag protein of the murine AIDS (MAIDS) defective virus promotes the proliferation of the infected target B cells and is responsible for inducing a severe immunodeficiency disease. Using the yeast two-hybrid system, we identified the SH3 domain of c-Abl as interacting with the proline-rich p12 domain of Pr60gag
Specific repression of Tax trans-activation by TAR RNA-binding protein TRBP.: J Virol. 1997 Apr;71(4):2628-35. Unique Identifier : AIDSLINE MED/97213926; Donzeau M; Winnacker EL; Meisterernst M; Laboratorium fur Molekulare Biologie-Genzentrum der; Ludwig-Maximilians-Universitat Munchen, Munich, Germany.; The human T-cell leukemia virus type 1 (HTLV-1)-encoded Tax protein activates transcription from the long terminal repetition via association with host cellular factors. In this study, we searched for cellular proteins that interact with Tax and modulate its activity by using the yeast two-hybrid system. One of the st
Evolution and probable transmission of intersubtype recombinant human immunodeficiency virus type 1 in a Zambian couple.: J Virol. 1997 Apr;71(4):2647-55. Unique Identifier : AIDSLINE MED/97213928; Salminen MO; Carr JK; Robertson DL; Hegerich P; Gotte D; Koch C; Sanders-Buell E; Gao F; Sharp PM; Hahn BH; Burke DS; McCutchan FE; Henry M. Jackson Foundation and Division of Retrovirology, Walter Reed; Army Institute of Research, Rockville, Maryland 20850, USA.; mika.salminen@ktl.fi; The extraordinary genetic diversity of human immunodeficiency virus type 1 (HIV-1) results from the introduction of mutations by an error-prone reverse transcriptase and from recombination of the two RNA genomes packaged in the virion during the synthesis of proviral DNA. The occurrence of multiple, genetically distan
Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein.: J Virol. 1997 Apr;71(4):2674-84. Unique Identifier : AIDSLINE MED/97213931; Earl PL; Broder CC; Doms RW; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-0445, USA.; pearl@atlas.niaid.nih.gov; The biologically relevant form of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein is oligomeric, with the major points of contact between oligomeric partners located in the ectodomain of gp41. To identify and map conserved epitopes and regions in gp41 where structure is influenced by quater
Inhibition of recombinant human immunodeficiency virus type 1 replication by a site-specific recombinase.: J Virol. 1997 Apr;71(4):2685-92. Unique Identifier : AIDSLINE MED/97213932; Flowers CC; Woffendin C; Petryniak J; Yang S; Nabel GJ; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0650, USA.; Current molecular genetic strategies to inhibit productive human immunodeficiency virus type 1 (HIV-1) replication have involved the generation of gene products which provide intracellular inhibition of essential virally encoded proteins or RNA structures. A molecular strategy to excise proviral DNA from HIV-1-infecte
Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry.: J Virol. 1997 Apr;71(4):2705-14. Unique Identifier : AIDSLINE MED/97213934; Chen Z; Zhou P; Ho DD; Landau NR; Marx PA; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York, New York 10016, USA.; Entry of human immunodeficiency virus type 1 (HIV-1) requires CD4 and one of a family of related seven-transmembrane-domain coreceptors. Macrophage-tropic HIV-1 isolates are generally specific for CCR5, a receptor for the CC chemokines RANTES, MIP-1alpha, and MIP-1beta, while T-cell line-tropic viruses tend to use CXC
Transduction of CD34+ hematopoietic progenitor cells with an antitat gene protects T-cell and macrophage progeny from AIDS virus infection.: J Virol. 1997 Apr;71(4):2740-6. Unique Identifier : AIDSLINE MED/97213938; Rosenzweig M; Marks DF; Hempel D; Lisziewicz J; Johnson RP; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772, USA.; Transduction of hematopoietic stem cells with genes that inhibit human immunodeficiency virus (HIV) replication has the potential to reconstitute immune function in individuals with AIDS. We evaluated the ability of an autoregulated gene, antitat, to inhibit replication of simian immunodeficiency virus (SIV) and HIV t
Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.: J Virol. 1997 Apr;71(4):2747-56. Unique Identifier : AIDSLINE MED/97213939; Tonjes RR; Limbach C; Lower R; Kurth R; Paul-Ehrlich-Institut, Langen, Germany. Toenjes@em.uni-frankfurt.de; The human endogenous retrovirus type K (HERV-K) family codes for the human teratocarcinoma-derived retrovirus (HTDV) particles. The existence of the envelope protein (ENV) of HERV-K encoded by the subgenomic env mRNA has not yet been demonstrated. To study the genetic requirements for successful expression of ENV, we
Exon 1 leader sequences downstream of U5 are important for efficient human immunodeficiency virus type 1 gene expression.: J Virol. 1997 Apr;71(4):2757-64. Unique Identifier : AIDSLINE MED/97213940; Lenz C; Scheid A; Schaal H; Center of Biological and Medical Research and Institut fur; Medizinische Mikrobiologie und Virologie, Heinrich-Heine-Universitat,; Dusseldorf, Germany.; In previous studies, little attention has been paid to maintaining the native HIV-1 leader sequence in reporter constructs analyzing the human immunodeficiency virus type 1 HIV-1) promoter activity. To investigate a possible influence of the leader sequence on HIV-1-driven gene expression in the presence as well as in
Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex.: J Virol. 1997 Apr;71(4):2779-85. Unique Identifier : AIDSLINE MED/97213943; Fouts TR; Binley JM; Trkola A; Robinson JE; Moore JP; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York, New York 10016, USA.; To test whether antibodies that are neutralizing or nonneutralizing for human immunodeficiency virus type 1 (HIV-1) primary isolates can be distinguished by their affinities for the oligomeric envelope glycoproteins, we selected HIV-1(JR-FL) as a model primary virus and a panel of 13 human monoclonal antibodies MAbs)
Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1.: J Virol. 1997 Apr;71(4):2799-809. Unique Identifier : AIDSLINE MED/97213946; Binley JM; Klasse PJ; Cao Y; Jones I; Markowitz M; Ho DD; Moore JP; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York, New York 10016, USA.; We have studied the antibody responses to Env and Gag antigens of human immunodeficiency virus type 1 (HIV-1) in several cohorts of HIV-1-infected individuals: long-term nonprogressors, progressors to disease, acute seroconvertors, and recipients of HIV-1 protease inhib
Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.: J Virol. 1997 Apr;71(4):2810-8. Unique Identifier : AIDSLINE MED/97213947; Ciminale V; Zotti L; D'Agostino DM; Chieco-Bianchi L; Department of Oncology and Surgical Sciences, University of Padua,; Italy. ciminale@ux1.unipd.it; Three mRNA species encoding the x-III open reading frame are expressed in human T-cell leukemia virus type 2 (HTLV-2)-infected cells. An mRNA composed of exons 1, 2, and 3 produces the essential posttranscriptional regulator Rex; shorter 1-3 and 1-B mRNAs encode a family of x-III proteins of unknown function that repr
Circular forms of unintegrated human immunodeficiency virus type 1 DNA and high levels of viral protein expression: association with dementia and multinucleated giant cells in the brains of patients with AIDS.: J Virol. 1997 Apr;71(4):2928-33. Unique Identifier : AIDSLINE MED/97213962; Teo I; Veryard C; Barnes H; An SF; Jones M; Lantos PL; Luthert P; Shaunak S; Department of Infectious Diseases, Royal Postgraduate Medical School,; London, United Kingdom.; Thirty-one histologically abnormal brains from patients with AIDS were studied in order to establish the relationship between multinucleated giant cells, viral protein expression, the various forms of human immunodeficiency virus type 1 (HIV-1) DNA, and clinical evidence of dementia
Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus.: J Virol. 1997 Apr;71(4):3013-22. Unique Identifier : AIDSLINE MED/97213972; Simard C; Klein SJ; Mak T; Jolicoeur P; Laboratory of Molecular Biology, Clinical Research Institute of; Montreal, Quebec, Canada.; Murine AIDS (MAIDS) is induced by a defective retrovirus that infects lymphocyte cells of the B lineage. To determine whether functional T cells are required for the infection of B cells, T-cell-deficient mice (nude, CD4 knockout, and SCII)) were infected with helper-free stocks of the MAIDS defective virus. Infection
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase.: J Virol. 1997 Apr;71(4):3023-30. Unique Identifier : AIDSLINE MED/97213973; Borkow G; Barnard J; Nguyen TM; Belmonte A; Wainberg MA; Parniak MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.; UC781, a thiocarboxanilide nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), inhibited RT DNA polymerase activity in vitro with marked potency. Significant inhibition was noted at a 1:1 molar ratio of UC871 to RT, characteristic of a tight-binding inhibitor. Infectivity
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector.: J Virol. 1997 Apr;71(4):3031-8. Unique Identifier : AIDSLINE MED/97213974; Caley IJ; Betts MR; Irlbeck DM; Davis NL; Swanstrom R; Frelinger JA; Johnston RE; Department of Microbiology, School of Medicine, University of North; Carolina, Chapel Hill 27599, USA.; A molecularly cloned attenuated strain of Venezuelan equine encephalitis virus (VEE) has been genetically configured as a replication-competent vaccine vector for the expression of heterologous viral proteins (N. L. Davis, K. W. Brown, and R. E. Johnston, J. Virol. 70:3781-3787, 1996). The matrix/capsid MA/CA) coding
Multigene antiviral vectors inhibit diverse human immunodeficiency virus type 1 clades.: J Virol. 1997 Apr;71(4):3048-53. Unique Identifier : AIDSLINE MED/97213976; Gervaix A; Li X; Kraus G; Wong-Staal F; Department of Medicine, University of California, San Diego, La Jolla; 92093-0665, USA.; The chronicity of infection by the human immunodeficiency virus HIV) calls for therapeutic regimens that offer sustained antiviral effects, such as gene therapy. Recent studies have demonstrated that expression of HIV mutant transdominant proteins, RNA decoys, and ribozymes efficiently inhibited HIV replication. We ha
Identification, expression, and immunogenicity of Kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen.: J Virol. 1997 Apr;71(4):3069-76. Unique Identifier : AIDSLINE MED/97213979; Lin SF; Sun R; Heston L; Gradoville L; Shedd D; Haglund K; Rigsby M; Miller G; Department of Molecular Biophysics & Biochemistry, Yale University; School of Medicine, New Haven, Connecticut 06520, USA.; We describe a recombinant antigen for use in serologic tests for antibodies to Kaposi s sarcoma (KS)-associated herpesvirus KSHV). The cDNA for a small viral capsid antigen (sVCA) was identified by immunoscreening of a library prepared from the BC-1 body cavity lymphoma cell line induced into KSHV lytic gene expressio
Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.: J Virol. 1997 Apr;71(4):3120-8. Unique Identifier : AIDSLINE MED/97213986; Yang OO; Kalams SA; Trocha A; Cao H; Luster A; Johnson RP; Walker BD; AIDS Research Center, Massachusetts General Hospital and Harvard; Medical School, Charlestown 02129, USA.; Although CD8+ lymphocytes in human immunodeficiency virus type 1 HIV-1)-infected individuals have been demonstrated to suppress viral replication, the mechanisms of inhibition have not been defined precisely. A large body of evidence indicates that these cells act via soluble inhibitory factors, but the potential role
Distinct domains of IkappaB-alpha inhibit human immunodeficiency virus type 1 replication through NF-kappaB and Rev.: J Virol. 1997 Apr;71(4):3161-7. Unique Identifier : AIDSLINE MED/97213990; Wu BY; Woffendin C; MacLachlan I; Nabel GJ; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0650, USA.; Among the regulators of human immunodeficiency virus (HIV) replication is the cellular transcription factor NF-kappaB, whose activity is regulated through inhibition by IkappaB family members. We have shown previously that I kappaB-alpha inhibits HIV type 1 (HIV-1) replication, and unexpectedly, IkappaB-alpha was foun
The cytoplasmic and transmembrane domains of the vaccinia virus B5R protein target a chimeric human immunodeficiency virus type 1 glycoprotein to the outer envelope of nascent vaccinia virions.: J Virol. 1997 Apr;71(4):3178-87. Unique Identifier : AIDSLINE MED/97213992; Katz E; Wolffe EJ; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-0445, USA.; The outer envelope of the extracellular form of vaccinia virus EEV) is derived from the Golgi membrane and contains at least six viral proteins. Transfection studies indicated that the EEV protein encoded by the B5R gene associates with Golgi membranes when synthesized in the absence of other viral products. A domain
Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation.: J Virol. 1997 Apr;71(4):3219-27. Unique Identifier : AIDSLINE MED/97213996; Rana S; Besson G; Cook DG; Rucker J; Smyth RJ; Yi Y; Turner JD; Guo HH; Du JG; Peiper SC; Lavi E; Samson M; Libert F; Liesnard C; Vassart G; Doms RW; Parmentier M; Collman RG; Division of Pulmonary and Critical Care, University of Pennsylvania; School of Medicine, Philadelphia 19104, USA.; The alpha-chemokine receptor fusin (CXCR-4) and beta-chemokine receptor CCR5 serve as entry cofactors for T-cell (T)-tropic and macrophage (M)-tropic human immunodeficiency virus type 1 (HIV-1) strains, respectively, when expressed with CD4 in otherwise nonpermissive cells. Some M-tropic and dual-tropic strains can al
Human immunodeficiency virus type 1 RNA outside the primary encapsidation and dimer linkage region affects RNA dimer stability in vivo.: J Virol. 1997 Apr;71(4):3250-4. Unique Identifier : AIDSLINE MED/97214000; Sakuragi JI; Panganiban AT; McArdle Laboratory for Cancer Research, University of; Wisconsin-Madison, 53706, USA.; To characterize the cis-acting determinants that function in RNA dimer formation and maintenance, we examined the stability of RNA dimers isolated from virus particles containing mutations in the encapsidation region of human immunodeficiency virus type 1 HIV-1). The genomic RNAs of all mutants containing lesions in e
Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin).: J Virol. 1997 Apr;71(4):3259-62. Unique Identifier : AIDSLINE MED/97214002; Pleskoff O; Sol N; Labrosse B; Alizon M; INSERM U.332, Institut Cochin de Genetique Moleculaire, Paris, France.; A clade B strain of human immunodeficiency virus type 1 HIV-1(LAI)) could infect CD4+ cells expressing human CXCR-4 fusin) or its rat homolog with similar efficacy. By contrast, cells expressing rat CXCR-4 were not permissive to HIV-1(NDK) clade D), HIV-2(ROD), or HIV-1(LAI) with chimeric envelope protein gp120 bearin
Polyclonal bovine sera but not virus-neutralizing monoclonal antibodies block bovine leukemia virus (BLV) gp51 binding to recombinant BLV receptor BLVRcp1.: J Virol. 1997 Apr;71(4):3263-7. Unique Identifier : AIDSLINE MED/97214003; Orlik O; Ban J; Hlavaty J; Altaner C; Kettmann R; Portetelle D; Splitter GA; Department of Animal Health and Biomedical Sciences, University of; Wisconsin-Madison, 53706, USA.; Bovine leukemia virus (BLV), a transactivating lymphotropic retrovirus, is the etiologic agent of enzootic lymphosarcoma or leukemia in cattle. Sera from BLV-infected animals possess high BLV-neutralizing antibody titres. The availability of the recombinant BLV receptor candidate, BLVRcp1, allowed us to determine a me
Human immunodeficiency virus drug therapy and virus load.: J Virol. 1997 Apr;71(4):3275-8. Unique Identifier : AIDSLINE MED/97214005; Bonhoeffer S; Coffin JM; Nowak MA; Wellcome Centre for the Epidemiology of Infectious Disease, Department; of Zoology, University of Oxford, United Kingdom. seb@zoo.ox.ac.uk; Analysis of the short-term dynamics of human immunodeficiency virus (HIV) type 1 infection in response to drug therapy has elucidated crucial kinetic properties of viral dynamics in vivo D. D. Ho et al., Nature 373:123-126, 1995; A. S. Perelson et al., Science 271:1582-1586, 1996; X. Wei et al., Nature 373:117-122, 19
Expression of a murine leukemia virus Gag-Escherichia coli RNase HI fusion polyprotein significantly inhibits virus spread.: J Virol. 1997 Apr;71(4):3312-8. Unique Identifier : AIDSLINE MED/97214012; VanBrocklin M; Ferris AL; Hughes SH; Federspiel MJ; Molecular Medicine Program, Mayo Clinic and Mayo Foundation,; Rochester, Minnesota 55905, USA.; The antiviral strategy of capsid-targeted viral inactivation CTVI) was designed to disable newly produced virions by fusing a Gag or Gag-Pol polyprotein to a degradative enzyme (e.g., a nuclease or protease) that would cause the degradative enzyme to be inserted into virions during assembly. Several new experimental a
Replication-competent chimeric lenti-oncovirus with expanded host cell tropism.: J Virol. 1997 Apr;71(4):3328-31. Unique Identifier : AIDSLINE MED/97214015; Reiprich S; Gundlach BR; Fleckenstein B; Uberla K; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany.; Baboon bone marrow was grafted into human immunodeficiency virus type 1-infected patients in the course of recent trials for AIDS treatment. Since the baboon genome harbors multiple copies of an endogenous oncovirus, chimeric lenti-oncoviruses could emerge in the xenotransplant recipient. To analyze the potential repl
Truncation of the human immunodeficiency virus type 1 envelope glycoprotein allows efficient pseudotyping of Moloney murine leukemia virus particles and gene transfer into CD4+ cells.: J Virol. 1997 Apr;71(4):3341-5. Unique Identifier : AIDSLINE MED/97214018; Mammano F; Salvatori F; Indraccolo S; De Rossi A; Chieco-Bianchi L; Gottlinger HG; Institute of Oncology, Interuniversity Center for Cancer Research,; University of Padua, Italy. mammano@ipdunidx.unipd.it; Human immunodeficiency virus type 1 (HIV-1) can readily accept envelope (Env) glycoproteins from distantly related retroviruses. However, we previously showed that the HIV-1 Env glycoprotein complex is excluded even from particles formed by the Gag proteins of another lentivirus, visna virus, unless the matrix domain
Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase.: J Virol. 1997 Apr;71(4):3346-50. Unique Identifier : AIDSLINE MED/97214019; Keulen W; Back NK; van Wijk A; Boucher CA; Berkhout B; Eijkman-Winkler Institute, Department of Virology, University Hospital; Utrecht, The Netherlands.; Treatment of human immunodeficiency virus type 1-infected patients with lamivudine ( 3TC ) results in the appearance of drug-resistant virus variants with a mutation at the 184Met codon ATG) of the reverse transcriptase (RT) gene. The 184Ile (ATA) varia
Human immunodeficiency virus type 2 preintegration complexes: activities in vitro and response to inhibitors.: J Virol. 1997 Apr;71(4):3351-6. Unique Identifier : AIDSLINE MED/97214020; Hansen MS; Bushman FD; Infectious Disease Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; We have established an assay for the function of preintegration complexes (PICs) of human immunodeficiency virus type 2 (HIV-2) to investigate the integration mechanism and to develop additional methods for screening candidate integration inhibitors. We partially purified HIV-2 PICs and found that they were competent
Molecular genetic biomarkers in hematological malignancies.: J Cell Biochem Suppl. 1996;25:165-71. Unique Identifier : AIDSLINE MED/97179328; Bagg A; Cossman J; Department of Pathology, Georgetown University Medical Center,; Washington, DC 20007-2197, USA.; Most hematopoietic malignancies are widely disseminated even in their early stages and often do not have a well-defined localized phase. This makes them less amenable to conventional early screening methods such as imaging and observation. Furthermore, the staging systems for lymphomas are not particularly useful pr
[Serotypes of the human immunodeficiency virus type 1 in Madrid]: Med Clin (Barc). 1997 Feb 15;108(6):217-20. Unique Identifier : AIDSLINE MED/97222053; Soriano V; Dietrich U; Mas A; Andersen R; Bravo R; Ruppach H; Gutierrez M; Martinez-Zapico R; Rubsamen-Waigmann H; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III,; Madrid.; BACKGROUND: HIV-1 shows high genetic variability, mainly in the genomic region codifying the envelope proteins, which are the most immunogenic. This fact explains the high heterogeneity of antibodies against HIV-1 epitopes. Both genetic and serologic diversity has allowed to classify HIV-1 variants in several subtypes
[Spontaneous bacterial peritonitis and primary hepatic lymphoma in a female patient with human immunodeficiency virus infection letter)]: Med Clin (Barc). 1997 Feb 15;108(6):238. Unique Identifier : AIDSLINE MED/97222062; Sancho JM; Ribera JM; Vaquero M; Feliu E
Pneumocystis carinii pneumonia.: Med Clin North Am. 1997 Mar;81(2):299-318. Unique Identifier : AIDSLINE MED/97247096; Santamauro JT; Stover DE; Pulmonary Service, Memorial Sloan-Kettering Cancer Center, New York,; New York, USA.; Pneumocystis carinii pneumonia (PCP) remains an important complication of AIDS. Advances have been made in establishing the taxonomy of the organism but the life cycle of the organism and pathogenetic mechanisms of disease remain obscure. In HIV patients the incidence of PCP has decreased because of widespread use of
Bacterial infections.: Med Clin North Am. 1997 Mar;81(2):319-43. Unique Identifier : AIDSLINE MED/97247097; Kovacs A; Leaf HL; Simberkoff MS; Infectious Diseases Section, New York Department of Veterans Affairs; Medical Center, New York, USA.; Non-opportunistic bacterial infections are an important cause of morbidity and mortality for HIV-infected adults and children. Factors associated with increased risk of these include altered B- and T-cell function; altered phagocytic cell function; skin and mucous membrane defects; and use of indwelling vascular cathe
Tuberculosis and human immunodeficiency virus infection.: Med Clin North Am. 1997 Mar;81(2):345-60. Unique Identifier : AIDSLINE MED/97247098; Telzak EE; Division of Infectious Diseases, Bronx-Lebanon Hospital Center, New; York, USA.; Mycobacterium tuberculosis infects one third of the world s population, and tuberculosis remains one of the most common infectious diseases of humans. From a global perspective, tuberculosis may be one of the most common HIV-related opportunistic infections. HIV immunosuppression has had a dramatic influence on the ep
Nontuberculous mycobacterial infections.: Med Clin North Am. 1997 Mar;81(2):361-79. Unique Identifier : AIDSLINE MED/97247099; French AL; Benator DA; Gordin FM; Department of Medicine, Rush Medical College, Chicago, Illinois, USA.; The acquired immunodeficiency syndrome (AIDS) pandemic has led to greater understanding and respect for the pathogenic potential of non-tuberculous mycobacteria. Mycobacterium avium complex (MAC) has emerged as the most common systemic bacterial infection in AIDS, causing debilitating disseminated disease in late-stag
Fungal infections in patients with acquired immunodeficiency syndrome.: Med Clin North Am. 1997 Mar;81(2):381-409. Unique Identifier : AIDSLINE MED/97247100; Minamoto GY; Rosenberg AS; Department of Clinical Medicine, Columbia University, New York, New; York, USA.; The incidence and severity of fungal infections appear to increase with progression of HIV disease. Because of the significant morbidity and mortality associated with the mycoses discussed, knowledge of the clinical syndromes, early diagnosis, and prompt institution of therapy are crucial for a favorable outcome. For
Viral infections in human immunodeficiency virus disease.: Med Clin North Am. 1997 Mar;81(2):411-26. Unique Identifier : AIDSLINE MED/97247101; Cavert W; Department of Medicine, University of Minnesota School of Medicine; Minneapolis, USA.; A number of the herpesviruses as well as representatives of other viral genera can produce serious opportunistic infections in persons infected with HIV. Although some, such as JC virus, HHV-6, and HHV-8, remain essentially untreatable at this time, others are readily treatable or can be retarded with chemoprophylaxis
Agents of diarrhea.: Med Clin North Am. 1997 Mar;81(2):427-47. Unique Identifier : AIDSLINE MED/97247102; Framm SR; Soave R; Department of Medicine, New York Hospital-Cornell Medical Center, New; York, USA.; Diarrhea is a common problem for AIDS patients, and is chronic and debilitating. A thorough evaluation will reveal a pathogen in the majority of patients, and the organisms most frequently identified in AIDS patients with chronic diarrhea are Cryptosporidium, microsporidia, and Mycobacterium avium complex. Bacterial p
Hematologic complications of human immunodeficiency virus infection and the acquired immunodeficiency syndrome.: Med Clin North Am. 1997 Mar;81(2):449-70. Unique Identifier : AIDSLINE MED/97247103; Coyle TE; Department of Medicine, State University of New York Health Science; Center at Syracuse, USA.; The hematologic manifestations of HIV infection and AIDS are common and may cause symptoms that are life-threatening and impair the quality of life of these patients. The most important of these manifestations are cytopenias. Anemia and neutropenia are generally caused by inadequate production because of suppression o
Acquired immunodeficiency syndrome-associated Kaposi's sarcoma. Biology and management.: Med Clin North Am. 1997 Mar;81(2):471-94. Unique Identifier : AIDSLINE MED/97247104; Krown SE; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New; York, New York, USA.; Kaposi s Sarcoma (KS), the most common AIDS-associated malignancy, occurs with increased frequency in all HIV transmission groups, but at a particularly high rate in homosexual men. Recent studies suggest that KS pathogenesis involves exposure to an infectious agent, altered expression and response to cytokines, and m
Human immunodeficiency virus-associated lymphomas.: Med Clin North Am. 1997 Mar;81(2):495-510. Unique Identifier : AIDSLINE MED/97247105; Straus DJ; Department of Medicine, Lymphoma Service, Memorial Sloan-Kettering; Cancer Center, New York, New York, USA.; Lymphomas associated with human immunodeficiency virus (HIV) will probably become an increasing problem with improved survivals of infected individuals in an immunosuppressed state because of the advances in antiretroviral treatment and the therapy of opportunistic infections. In an attempt to aid the understanding of
Oral manifestations of human immunodeficiency virus infection.: Med Clin North Am. 1997 Mar;81(2):511-31. Unique Identifier : AIDSLINE MED/97247106; Phelan JA; Department of Veterans Affairs Medical Center, Northport, New York,; USA.; This article includes the oral manifestations which have been reported to be associated with human immunodeficiency virus (HIV) infection. The clinical appearance, diagnostic criteria and treatment of fungal, viral and bacterial infections, neoplasms and lesions of uncertain etiology are described. Accurate diagnosis
Human immunodeficiency virus infection in women.: Med Clin North Am. 1997 Mar;81(2):533-53. Unique Identifier : AIDSLINE MED/97247107; Anastos K; Denenberg R; Solomon L; Ambulatory Care Network, Montefiore Medical Center, University; Hospital, Albert Einstein College of Medicine, Bronx, New York, USA.; This article describes current epidemiologic trends in HIV infection in women worldwide and in the United States , the natural history of HIV infection in women as currently understood, clinical management of HIV-infected women in those areas in which it differs from men, and multiple i
Risks and issues for the health care worker in the human immunodeficiency virus era.: Med Clin North Am. 1997 Mar;81(2):555-75. Unique Identifier : AIDSLINE MED/97247108; Weiss SH; Division of Infectious Diseases Epidemiology, University of Medicine; and Dentistry of New Jersey-New Jersey Medical School, Newark, USA.; The perception of degree of risk can vary markedly from actual risk. About 5% of the cases of AIDS and HIV infection in the United States have occurred in health care workers, a percentage that has remained stable over time. Nearly all of these infections are related to lifestyle facto
[The HIV tragedy in India: twelve million will probably be HIV-positive in the year of 2000. Mostly suffering are the vulnerable women]: Lakartidningen. 1997 Mar 5;94(10):801-4. Unique Identifier : AIDSLINE MED/97241434; Svensson P
[HIV and chemokine receptors. New explanations of the biology and virulence of the virus]: Lakartidningen. 1997 Mar 5;94(10):824-8. Unique Identifier : AIDSLINE MED/97241444; Fenyo EM; Samuelsson A; Mikrobiologiskt och tumorbiologiskt centrum, Karolinska institutet,; Stockholm.
Unique monocyte subset in patients with AIDS dementia.: Lancet. 1997 Mar 8;349(9053):692-5. Unique Identifier : AIDSLINE MED/97232965; Pulliam L; Gascon R; Stubblebine M; McGuire D; McGrath MS; Department of Laboratory Medicine, University of California, San; Francisco, USA. pulliam@pangloss.ucsf.edu; BACKGROUND: 15-30% of patients infected with HIV will develop a debilitating dementia . Whilst HIV enters the brain soon after infection, presumably within monocyte-derived macrophages, not all patients with HIV become demented. Blood monocytes probably cross the blood-brain barrier
Medicinal marijuana? [letter]: N Engl J Med. 1997 Apr 17;336(16):1186; discussion 1186-7. Unique Identifier : AIDSLINE MED/97238771; Tashkin DP; Roth MD; Dubinett SM
Intralesional human chorionic gonadotropin for Kaposi's sarcoma [letter; comment]: N Engl J Med. 1997 Apr 17;336(16):1187; discussion 1188-9. Unique Identifier : AIDSLINE MED/97238772; Harris PJ
Intralesional human chorionic gonadotropin for Kaposi's sarcoma [letter; comment]: N Engl J Med. 1997 Apr 17;336(16):1187-8; discussion 1188-9. Unique Identifier : AIDSLINE MED/97238774; Grulich AE; Kaldor JM
Implications and management of oral diseases in children and adolescents with HIV infection.: N Y State Dent J. 1997 Feb;63(2):46-50. Unique Identifier : AIDSLINE MED/97245557; Ferguson FS; Nachman S; Berentsen B; State University, Stony Brook School of Dental Medicine, Pediatric; Dental Infectious Disease Clinic, USA.; The impact of human immunodeficiency virus (HIV) infection on children continues to be felt worldwide. Since 1981, when the first patients with HIV were recognized, to 1996, when it was estimated that more than 14 million men, women and children were infected with the virus, no other infectious disease has had such a
Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells.: Oncogene. 1997 Mar 6;14(9):1083-91. Unique Identifier : AIDSLINE MED/97224076; Carrozza ML; Jacobs H; Acton D; Verma I; Berns A; Division of Molecular Genetics of the Netherlands Cancer Institute,; Amsterdam.; We have examined the role of the AP-1 transcription factor on thymocyte maturation and thymus architecture by overexpressing FosB2 in transgenic mice. FosB2 is a naturally occurring splice variant of the FosB2 gene, encoding a truncated protein which lacks two domains necessary for transcriptional activation. The expr
Effect of influenza immunization on immunologic and virologic characteristics of pediatric patients infected with human immunodeficiency virus.: Pediatr Infect Dis J. 1997 Feb;16(2):200-4. Unique Identifier : AIDSLINE MED/97194023; Jackson CR; Vavro CL; Valentine ME; Pennington KN; Lanier ER; Katz SL; Diliberti JH; McKinney RE; Wilfert CM; St Clair MH; Duke University Medical Center, Durham, NC, USA.; OBJECTIVES: We evaluated the responses of HIV-infected children to a single dose of split-virus influenza vaccine and the relationship to viral load and other characteristics. METHODS: Fifty-three HIV-infected children ages 1.8 to 13.2 years were given influenza vaccine for the 1994 to 1995 influenza season Wyeth-Ayer
Plasma viremia and virus phenotype are correlates of disease progression in vertically human immunodeficiency virus type 1-infected children.: Pediatr Infect Dis J. 1997 Feb;16(2):205-11. Unique Identifier : AIDSLINE MED/97194024; Balotta C; Colombo MC; Colucci G; Vigano A; Riva C; Papagno L; Violin M; Crupi L; Bricalli D; Salvaggio A; Moroni M; Principi N; Galli M; Clinica delle Malattie Infettive, University of Milan, Italy.; balotta@imiucca.csi.unimi.it; OBJECTIVE: To analyze the relationships among HIV-1 plasma viremia, phenotype and CD4 T cell counts in vertically infected children. METHODS: Plasma viremia was quantified in 37 vertically infected children at different stages of the disease by a standardized molecular assay. Virus isolation and non-syncytia-inducing
Structure of a primary care support system to coordinate comprehensive care for children and families infected/affected by human immunodeficiency virus in a managed care environment.: Pediatr Infect Dis J. 1997 Feb;16(2):211-6. Unique Identifier : AIDSLINE MED/97194025; Havens PL; Cuene BE; Waters D; Hand J; Chusid MJ; Department of Pediatrics, Medical College of Wisconsin, Milwaukee,; USA.; BACKGROUND: Children with HIV infection require coordinated primary and tertiary care. OBJECTIVES: To describe the structure of the Wisconsin HIV Primary Care Support Network, a decentralized program for care of children and families infected or affected by HIV infection. METHODS: Review of data concerning all childre
Invasive aspergillosis in human immunodeficiency virus-infected children.: Pediatr Infect Dis J. 1997 Feb;16(2):216-21. Unique Identifier : AIDSLINE MED/97194026; Shetty D; Giri N; Gonzalez CE; Pizzo PA; Walsh TJ; Infectious Diseases Section, National Cancer Institute, Bethesda, MD; 20892, USA.; BACKGROUND: Aspergillosis is an uncommon yet serious opportunistic infection in patients with AIDS. It has been extensively reported in HIV-infected adult patients. To our knowledge there are no studies that describe the epidemiology, clinical manifestations and outcome of aspergillosis in a large HIV-infected pediatr
Campylobacter sepsis in human immunodeficiency virus-infected children. The Madrid HIV Pediatric Infection Collaborative Study Group.: Pediatr Infect Dis J. 1997 Feb;16(2):251-3. Unique Identifier : AIDSLINE MED/97194034; Ruiz-Contreras J; Ramos JT; Hernandez-Sampelayo T; de Jose M; Clemente J; Gurbindo MD; Department of Pediatrics, Hospital Doce de Octubre, Universidad; Complutense, Madrid, Spain.
A high affinity binding site for the HIV-1 nucleocapsid protein.: Nucleic Acids Res. 1997 Mar 1;25(5):1042-9. Unique Identifier : AIDSLINE MED/97175811; Berglund JA; Charpentier B; Rosbash M; Howard Hughes Medical Institute and Department of Biology, Brandeis; University, Waltham, MA 02254, USA.; The nucleocapsid protein (NC) of HIV-1 is a small zinc finger protein that contributes to multiple steps of the viral life cycle, including the proper encapsidation of HIV RNA. This is accomplished through an interaction between NC and a region at the 5 -end of the RNA, defined as the Psi element. However, the specifi
Transcriptional modulation of viral reporter gene constructs following induction of the cellular stress response.: Nucleic Acids Res. 1997 Mar 1;25(5):1082-4. Unique Identifier : AIDSLINE MED/97175818; Andrews JM; Newbound GC; Lairmore MD; Center for Retrovirus Research and Department of Veterinary; Biosciences, The Arthur James Cancer Hospital and Research Institute,; The Ohio State University, Columbus, OH 43210, USA.; jan_andrews@ncsu.edu; In this study, we report that commonly used methods of transient transfection induce the cellular stress response and a recovery period is required following transfection when analyzing cellular stress responsive genes. Four transfection methods were examined for their ability to induce the stress response by measurin
Forced evolution of a regulatory RNA helix in the HIV-1 genome.: Nucleic Acids Res. 1997 Mar 1;25(5):940-7. Unique Identifier : AIDSLINE MED/97175797; Berkhout B; Klaver B; Das AT; Academic Medical Center, University of Amsterdam, Department of Human; Retrovirology, PO Box 22700, 1100 DE Amsterdam, The Netherlands.; b.berkhout@amc.uva.nl; The 5 and 3 end of the HIV-1 RNA genome forms a repeat (R) element that encodes a double stem-loop structure (the TAR and polyA hairpins). Phylogenetic analysis of the polyA hairpin in different human and simian immunodeficiency viruses suggests that the thermodynamic stability of the helix is fine-tuned. We demonstra
Encephalitozoon cuniculi microsporidiosis: infection of the brain, heart, kidneys, trachea, adrenal glands, and urinary bladder in a patient with AIDS.: Mod Pathol. 1997 Jan;10(1):68-77. Unique Identifier : AIDSLINE MED/97173830; Mertens RB; Didier ES; Fishbein MC; Bertucci DC; Rogers LB; Orenstein JM; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles,; California, USA.; A female AIDS patient, dying with widely disseminated Encephalitozoon cuniculi microsporidiosis , cytomegalovirus ( CMV ) disease, and Pneumocystis carinii infection, is describe
Tuberculosis in Africa: clinical presentation and management.: Pharmacol Ther. 1997;73(1):1-50. Unique Identifier : AIDSLINE MED/97166474; Harries AD; Department of Medicine, College of Medicine, Malawi, Central Africa.; In the last decade, sub-Saharan Africa has experienced an explosive increase in tuberculosis (TB) cases, largely as a result of the co-epidemic of human immunodeficiency virus (HIV) infection. This article reviews the essential background epidemiology of TB in sub-Saharan Africa. The clinical features and diagnostic p
The legend of the potholes: newsroom changes increase medical and health care news coverage.: Pharos. 1996 Summer;59(3):2-7. Unique Identifier : AIDSLINE MED/97228237; Bloom SG; School of Journalism and Mass Communication, University of Iowa, Iowa; City 52242-1592, USA.
Viral risks associated with blood transfusion.: Photochem Photobiol. 1997 Mar;65(3):428-31. Unique Identifier : AIDSLINE MED/97231861; Sloand EM; National Heart, Lung, and Blood Institute, Bethesda, MD, USA.; Great strides have been made within the last decade to help ensure the safety of the blood supply. Additional tests to detect infectious agents, as well as development of improved donor screening and deferral techniques have helped make the risk of transfusion-transmitted disease very low. Currently, blood banks perfo
Silicon phthalocyanine Pc 4 and red light causes apoptosis in HIV-infected cells.: Photochem Photobiol. 1997 Mar;65(3):456-60. Unique Identifier : AIDSLINE MED/97231867; Ben-Hur E; Oetjen J; Horowitz B; VITEX, Inc, New York, NY 10032, USA.; The silicon phthalocyanine HOSiPcOSi(CH3)2(CH2)3 N(CH3)2 (Pc 4), is being studied as a photosensitizer for virus inactivation in red blood cell concentrates (RBCC). The RBCC spiked with cell-free human immunodeficiency virus (HIV) or with HIV actively replicating in the T-lymphocytic cell line CEM can be successfully
Photosensitized decontamination of blood with the silicon phthalocyanine Pc 4: no activation of the human immunodeficiency virus promoter.: Photochem Photobiol. 1997 Mar;65(3):461-4. Unique Identifier : AIDSLINE MED/97231868; Zmudzka BZ; Strickland AG; Beer JZ; Ben-Hur E; Food and Drug Administration, Center for Devices and Radiological; Health, Rockville, MD, USA.; Photochemical decontamination of red blood cell concentrates RBCC) with the silicon phthalocyanine Pc 4 and red light is being studied to enhance the viral safety of blood transfusion. Recent reports indicate that treatments with radiation and various phototsensitizing agents can activate the promoter of human immunod
Transgenic and null mutant animals for psychosomatic research.: Psychosom Med. 1996 Nov-Dec;58(6):622-32. Unique Identifier : AIDSLINE MED/97103668; Crnic LS; Mental Retardation Research Center, University of Colorado School of; Medicine, Denver 80262, USA.; OBJECTIVE: Progress in the use of genetically altered animals for psychosomatic research is reviewed. METHOD: Analysis of the strengths and weaknesses of these models, particularly from a developmental and behavioral prospective is used to assess the validity of these models. RESULTS: Genetically altered animals can b
Avoidance coping behaviors and low social support are related to depressive symptoms in HIV-positive patients in Japan.: Psychosomatics. 1997 Mar-Apr;38(2):113-8. Unique Identifier : AIDSLINE MED/97217005; Fukunishi I; Hosaka T; Negishi M; Moriya H; Hayashi M; Matsumoto T; Tokyo Institute of Psychiatry, Tokyo, Japan.; The authors examined the influences of several psychosocial factors (i.e., coping behavior responses, social support, etc.) on mood states in 47 human immunodeficiency virus (HIV)-positive patients without the acquired immunodeficiency syndrome (AIDS). No patients fulfilled the DSM-III-R diagnostic criteria for mood d
Tracing patients exposed to health care workers with tuberculosis.: Public Health Rep. 1997 Mar-Apr;112(2):153-7. Unique Identifier : AIDSLINE MED/97224905; Zaza S; Beck-Sague CM; Jarvis WR; Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.; OBJECTIVES: Following an outbreak of tuberculosis (TB) among health care workers at a public hospital, the study was undertaken to (a) locate all exposed patients and administer tuberculin skin tests (TSTs) to them, (b) provide clinical treatment or prophylaxis to infected patients, and (c) ascertain the risk of M. tu
HIV and hepatitis B infection and risk behavior in young gay and bisexual men.: Public Health Rep. 1997 Mar-Apr;112(2):158-67. Unique Identifier : AIDSLINE MED/97224906; Seage GR 3rd; Mayer KH; Lenderking WR; Wold C; Gross M; Goldstein R; Cai B; Heeren T; Hingson R; Holmberg S; Boston Department of Health and Hospitals, USA. gseage@bu.edu; OBJECTIVES: To estimate the prevalence of and identify risk factors for human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) infections and unprotected anal intercourse among young homosexual and bisexual men. METHODS: The authors performed a cross-sectional analysis of data from a prospective cohor
[Antiviral agents that act in the early phases of the viral cycle]: Rev Argent Microbiol. 1996 Oct-Dec;28(4):204-16. Unique Identifier : AIDSLINE MED/97170329; Damonte EB; Departamento de Quimica Biologica, Facultad de Ciencias Exactas y; Naturales, Universidad de Buenos Aires, Argentina.; The development of antiviral chemotherapy against human immunodeficiency virus (HIV) and herpesvirus suffers from two main problems: the toxic side effects and the emergence of drug resistance associated to the continuous treatment of immunocompromised patients. A variety of compounds targeted at the early stages of t
Image interpretation session: 1996. Bronchial-associated lymphoid tissue (BALT).: Radiographics. 1997 Jan-Feb;17(1):256-8. Unique Identifier : AIDSLINE MED/97170292
Interpretation of chest radiographs in AIDS patients: usefulness of CD4 lymphocyte counts [published erratum appears in Radiographics 1997 May-Jun;17(3):804]: Radiographics. 1997 Jan-Feb;17(1):47-58; discussion 59-61. Unique Identifier : AIDSLINE MED/97170269; Shah RM; Kaji AV; Ostrum BJ; Friedman AC; Department of Radiology, Medical College of Pennsylvania, Philadelphia; 19129, USA.; Specific infections and neoplasms that are complications of acquired immunodeficiency syndrome (AIDS) occur within various CD4 lymphocyte count ranges. Knowledge of how these counts correlate with radiographic appearances of these entities can limit the differential diagnosis because certain conditions are uncommon ab
[Pneumocystis carinii pneumonia in patients with a solid organ transplant: a report of 5 cases (see comments)]: Rev Clin Esp. 1997 Jan;197(1):31-4. Unique Identifier : AIDSLINE MED/97216176; Ruiz Ruiz J; Yebra Bango M; Fernandez Fernandez J; Alonso Pulpon L; Cuervas-Mons Martinez V; Besada Estevez E; Daza Perez RM; Servicio de Medicina Interna I, Clinica Puerta de Hierro, Madrid.; A report is made here of five patients who underwent solid organ transplantation, were not infected with the human immunodeficiency virus, and suffered Pneumocystis carinii pneumonia while receiving immunosuppressive drugs. The figure represents a prevalence of 0.43% among patients with solid organ transplantation at
[Pulmonary cavitary lesions in a patient with HIV infection]: Rev Clin Esp. 1997 Jan;197(1):59-60. Unique Identifier : AIDSLINE MED/97216181; Cano Monchul R; Merino Munoz D; Creagh Cerquera R; Martinez Garcia T; Galvez Acebal J; Pujol de la Llave E; Servicio de Medicina Interna, Hospital Juan Ramon Jimenez, Huelva.
[Esophageal tuberculosis in an HIV-positive patient]: Rev Gastroenterol Mex. 1996 Jul-Sep;61(3):272. Unique Identifier : AIDSLINE MED/97139419; Rodriguez-Magallan A; Martinez de los Santos G; Bermudez-Villegas F; Servicio de Gastroenterologia, Hospital Juarez de Mexico, S.S.
Therapeutic factor XIII preparations and perspectives for recombinant factor XIII.: Semin Thromb Hemost. 1996;22(5):427-36. Unique Identifier : AIDSLINE MED/97143816; Karges HE; Metzner HJ; Centeon Pharma GmbH, Marburg, Germany.; With the increasing availability of human plasma this source was used to substitute for the production of factor XIII concentrate from placenta. Prior to changing the source material, the virus safety in accordance with the Committee for Proprietary Medicinal Products (CPMP) guidelines and the half-life were investiga
Social scientists and the new tuberculosis.: Soc Sci Med. 1997 Feb;44(3):347-58. Unique Identifier : AIDSLINE MED/97158091; Farmer P; Department of Social Medicine, Harvard Medical School, Boston, MA,; USA.; In much of the world, tuberculosis (TB) remains the leading killer of young adults, in spite of the fact that effective chemotherapy has existed for 50 years. The epidemiology of TB, with its persistence in poor countries and resurgence among the poor of many industrialized nations, causes consternation among those ch
Polymerase chain reaction testing for early detection of HIV infection in children.: South Med J. 1997 Mar;90(3):294-5. Unique Identifier : AIDSLINE MED/97230868; Midani S; Rathore MH; Division of Pediatric Infectious Diseases and Immunology, University; of Florida Health Science Center, Jacksonville, USA.; Diagnosis of vertically acquired human immunodeficiency virus HIV) infection is often difficult because of transplacentally acquired maternal antibodies. The polymerase chain reaction (PCR) test is commercially available and has high sensitivity and specificity. To evaluate the usefulness of PCR testing in the early d
Pharmacokinetic and toxicity studies of AZT (zidovudine) following perfusion of human term placenta for 14 hours.: Toxicol Appl Pharmacol. 1997 Mar;143(1):13-21. Unique Identifier : AIDSLINE MED/97236968; Boal JH; Plessinger MA; van den Reydt C; Miller RK; Department of Obstetrics and Gynecology, School of Medicine and; Dentistry, University of Rochester, New York 14642-8668, USA.; Multiple exposures to AZT (Zidovudine) for 14 hr were examined in the dually perfused human term placental lobule in order to determine the pharmacokinetics of transfer, as well as several viability parameters of toxicity. In each experiment, three se
Antiviral efficacy and toxicity of ribavirin and foscarnet each given alone or in combination in the murine AIDS model.: Toxicol Appl Pharmacol. 1997 Mar;143(1):140-51. Unique Identifier : AIDSLINE MED/97236983; Omar RF; Harvie P; Gourde P; Desormeaux A; Tremblay M; Beauchamp D; Bergeron MG; Centre de Recherche en Infectiologie, Faculte de Medecine, Universite; Laval, Quebec, Canada.; The antiviral efficacy and toxicity of ribavirin, foscarnet PFA), and combinations of both drugs at two different doses have been evaluated in the murine AIDS (MAIDS) model. Our results clearly demonstrated that infected mice treated with ribavirin at 100 mg/ kg/day were protected against splenomegaly, lymphadenopathy
Delays in diagnosis and treatment of smear-positive tuberculosis and the incidence of tuberculosis in hospital nurses in Blantyre, Malawi.: Trans R Soc Trop Med Hyg. 1997 Jan-Feb;91(1):15-7. Unique Identifier : AIDSLINE MED/97247490; Harries AD; Kamenya A; Namarika D; Msolomba IW; Salaniponi FM; Nyangulu DS; Nunn P; Department of Medicine, Queen Elizabeth Central Hospital, Blantyre,; Malawi.; There is little information about nosocomial transmission of tuberculosis (TB) in sub-Saharan Africa. A study was carried out to examine the process of diagnosis and treatment of smear-positive pulmonary TB patients in Queen Elizabeth Central Hospital, Blantyre, Malawi , and the inc
Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?: Transplantation. 1997 Mar 15;63(5):619-24. Unique Identifier : AIDSLINE MED/97230249; Piccotti JR; Chan SY; VanBuskirk AM; Eichwald EJ; Bishop DK; Department of Surgery, University of Michigan School of Medicine, Ann; Arbor, USA.
Recall response to cytomegalovirus in allograft recipients: mobilization of CD57+, CD28+ cells before expansion of CD57+, CD28- cells within the CD8+ T lymphocyte compartment.: Transplantation. 1997 Mar 15;63(5):693-8. Unique Identifier : AIDSLINE MED/97230262; Hazzan M; Labalette M; Noel C; Lelievre G; Dessaint JP; Service d'Immunologie, Faculte de Medecine et CHRU de Lille, France.; BACKGROUND: Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus ( CMV ) infection, in healthy individuals as well as in transplant patien
Direct recognition of rat MHC antigens on rat antigen-presenting cells by mouse CD4+ and CD8+ T cells and establishment of T cell clones exhibiting a direct recognition pathway.: Transplantation. 1997 Mar 15;63(5):705-10. Unique Identifier : AIDSLINE MED/97230264; Hirota T; Hirose H; Iwata H; Kanetake K; Murakawa S; Sasaki E; Takagi H; Bando M; Hamaoka T; Fujiwara H; First Department of Surgery, Gifu University Medical School, Japan.; Alloantigens are recognized by T cells either through a direct pathway, which involves recognition of alloantigens expressed on allogeneic antigen-presenting cells (APC), or through an indirect pathway, which involves recognition of processed alloantigens presented by self APC. We investigated whether rat xenoantigens
Diagnosis of HIV infection.: Trop Doct. 1997 Jan;27(1):39-41. Unique Identifier : AIDSLINE MED/97181882; Balint GA; Department of Neurology and Psychiatry, Albert Szent-Gyorgyi Medical; University, Szeged, Hungary.; AIDS is the clinical manifestation of cellular immunodeficiency caused by HIV infection. A characteristic feature of HIV-infection is the lifelong coexistence of HIV and antibodies against it in the blood. The routine diagnosis of HIV-positivity is based mainly on HIV-antibody screening by ELISA and confirmation by We
Mycobacterium ulcerans skin infection in a patient with HIV infection: is this incidental? [letter]: Trop Doct. 1997 Jan;27(1):59. Unique Identifier : AIDSLINE MED/97181893; Ameh EA; Dogo PM; Ahmed A; Maitama HY; Esangbedo AE; Nmadu PT
[Replicative properties of HIV-1 strains, resistant to 3'-azido-2'3'-dideoxythymidine]: Vopr Virusol. 1997 Jan-Feb;42(1):10-3. Unique Identifier : AIDSLINE MED/97216818; Selimova LM; Iurin OG; Pokrovskii VV; The replicative activity of two strains of human immunodeficiency virus type I, 1974 and 1978, resistant to 3 -azido-2 ,3 -dideoxythymidine ( AZT ), was investigated. Assessment of AZT sensitivity by the standard method showed the 50% effective dose (ED
[Genotyping and phylogenetic analysis of HIV-1 isolates circulating in Russia]: Vopr Virusol. 1997 Jan-Feb;42(1):13-6. Unique Identifier : AIDSLINE MED/97216819; Bobkov AF; Pokrovskii VV; Selimova LM; Kazennova EV; Karaseva NG; Ladnaia NN; Kravchenko AV; Cheingsong-Popov R; Veber D; HIV-1 genetic subtypes were analyzed by the heteroduplex mobility assay (HMA) in 125 samples derived in 1995-1996 from residents of the European part of Russia . The results indicate the prevalence of six subtypes (A, B, C, D, G, and H) in the Russian Federation, with four types (A,
[Study of anti-HIV activity of the yeast RNA-tilorone molecular complex]: Vopr Virusol. 1997 Jan-Feb;42(1):17-9. Unique Identifier : AIDSLINE MED/97216820; Karpov AV; Antonenko SV; Barbasheva EV; Spivak NIa; Anti-HIV activity of the molecular complex forming during interaction between yeast RNA and tilorone was studied in vitro on the models of acute and chronic infection. Addition of this agent to the cells infected with HIV-1/IIIB and HIV-1/BRU decreased the virus reproduction controlled by assessing the viability of ce
[Basic results of research on AIDS in 1995]: Vopr Virusol. 1997 Jan-Feb;42(1):2-5. Unique Identifier : AIDSLINE MED/97216816; Pokrovskii VI; Kraevskii AA; Pokrovskii VV; Uryvaev LV; Matsevich GR; Iurin OG; Galegov GA; Reshetnikova LN
[Effect of saponins from Hedera taurica Carr. and modified muramylpeptides on replication of human immunodeficiency virus in vitro]: Vopr Virusol. 1997 Jan-Feb;42(1):34-6. Unique Identifier : AIDSLINE MED/97216825; Krivorutchenko IuL; Andronovskaia IB; Chirva VIa; Pertel' SS; Grishkovets VI; Zemliakov AE; Kur'ianov VO; Krivoshein IuS; The effects of muramyldipeptide (MDP), several new MDP derivatives, and saponins derived from Hedera taurica Carr, on the in vitro replication of HIV-1 were studied. The coefficient of alteration of the rate of HIV replication was used to compare these reagents effects on virus replication in Jurkat-tat cells. This c
[The influence of phytohemagglutinin P on CD4+ and CD8+ cells in the course of experimental trichinellosis in mice]: Wiad Parazytol. 1996;42(4):421-7. Unique Identifier : AIDSLINE MED/97231849; Karmanska K; Houszka M; Stefaniak E; Instytut Parazytologii im. Witolda Stefanskiego PAN, Wroclaw.; Experiments were carried out with mice of CFW inbred strain infected with 200 Trichinella spiralis larvae and divided into two groups: experimental and control. The experimental mice were injected with phytohaemagglutinin P (PHA-P), 24 h before infection. The all animals were killed between 7-133 days post infection a
Evidence for the association of Nef protein with HIV-2 virions.: Virus Res. 1996 Dec;46(1-2):105-10. Unique Identifier : AIDSLINE MED/97181622; Fackler OT; Kremmer E; Mueller-Lantzsch N; Universitatskliniken des Saarlandes, Abt. Virologie, Homburg/Saar,; Germany.; HIV-Nef protein supports viral infectivity prior to proviral integration. This requires Nef to be present before the expression of viral genes and suggests its delivery as part of the virion. We report here that the Nef proteins of HIV-2-HOM and HIV-2-ROD are associated with the virion. After the separation of pellete
Serial passage of human immunodeficiency virus type 1 generates misalignment deletions in non-essential accessory genes.: Virus Res. 1996 Dec;46(1-2):139-47. Unique Identifier : AIDSLINE MED/97181625; Nakaya T; Fujinaga K; Doi H; Suzuki S; Takahashi H; Nishino Y; Kishi M; Azuma I; Luftig RB; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; Human immunodeficiency virus type 1 (HIV-1) derived from an infectious molecular clone pNL432 was extensively passaged in tissue culture by repeated rounds of acute infection. We previously showed the natural occurrence of a nonsense mutation in the vpr gene during continued passage of this virus. In this report, we s
Use of persistent infections with vaccinia virus recombinants to introduce alterations in foreign proteins: an application to HIV-1 env protein.: Virus Res. 1996 Dec;46(1-2):45-56. Unique Identifier : AIDSLINE MED/97181615; Esteban M; Ramon Rodriguez J; Jimenez V; Rodriguez D; Department of Cell and Molecular Biology, CSIC, Madrid, Spain.; mesteban@samba.cmb.uam.es; With the aim of generating a virus-cell system to introduce alterations in proteins of interest--which may be of use in studies of their biological functions--we established a persistent infection on a B-lymphoma cell line (A20.2J) with vaccinia virus (VV) recombinants. As a model, we used a vaccinia virus recombinant
[The identification of the genetic subtypes of HIV-1 circulating on the territory of Russia]: Zh Mikrobiol Epidemiol Immunobiol. 1996 Nov-Dec;(6):25-8. Unique Identifier : AIDSLINE MED/97211551; Leinikki P; Liitsola K; Laukkanen T; Salminen M; Smol'skaia T; Korovina G; Vlasov N; National Public Health Institute, Helsinki, Finland.; In this work the results of the genotyping of HIV strains obtained from 12 patients residing in Russia are presented. Proviral DNA from lysates of mononuclear cells was amplified with the use of primers, complementary to the conservative site of gene gag p7/p9 with the subsequent s
[The serological diagnosis of HIV/AIDS in children]: Zh Mikrobiol Epidemiol Immunobiol. 1996 Nov-Dec;(6):86-90. Unique Identifier : AIDSLINE MED/97211561; Leshchinskaia NP
Developing non-traditional print media for HIV prevention: role model stories for young urban women.: Am J Public Health. 1997 Feb;87(2):289-90. Unique Identifier : AIDSLINE MED/97226133; Bond L; Bowden-Proctor J; Lauby J; Walls C; Woll M; Philadelphia Health Management Corp, PA 19102, USA.
Causes of death in homeless adults in Boston.: Ann Intern Med. 1997 Apr 15;126(8):625-8. Unique Identifier : AIDSLINE MED/97243273; Hwang SW; Orav EJ; O'Connell JJ; Lebow JM; Brennan TA; Boston Health Care for the Homeless Program, Boston City Hospital,; Massachusetts, USA.; BACKGROUND: Homeless persons have high mortality rates. OBJECTIVE: To ascertain causes of death in a group of homeless persons. DESIGN: Cohort study. PATIENTS: 17,292 adults seen by the Boston Health Care for the Homeless Program from 1988 to 1993. MEASUREMENTS: Cause-specific mortality rates adjusted for race and rat
Testing sputum samples for HIV antibodies, using a rapid, saliva-card test system.: Ann Trop Med Parasitol. 1997 Jan;91(1):115-7. Unique Identifier : AIDSLINE MED/97247310; Gilks CF; Balbirnie E; Tropical Medicine Division, Liverpool School of Tropical Medicine,; U.K. charles.gilks@liv.ac.uk
The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat.: Biochem J. 1997 Feb 15;322 ( Pt 1):155-8. Unique Identifier : AIDSLINE MED/97233020; Liu YZ; Latchman DS; Department of Molecular Pathology, University College London Medical; School, U.K.; Although the HIV-1 long terminal repeat (LTR) contains four potential binding sites for the octamer-binding protein, Oct-1, which is known to interact with the HIV-1 Tat protein, the effect of the Oct-1 factor on HIV LTR-driven gene expression has not previously been reported. We show here that both Oct-1, and to a le
Transduction of human hematopoietic progenitor cells with retroviral vectors based on the gibbon ape leukemia virus.: Biochem Biophys Res Commun. 1997 Feb 13;231(2):477-80. Unique Identifier : AIDSLINE MED/97223483; Eglitis MA; Schneiderman RD; Laboratory of Cell Biology, National Institute of Mental Health,; Bethesda, Maryland 20892, USA. martin_eglitis@nih.gov; Gene transfer into human hematopoietic stem cells continues to be complicated by issues of transfer efficiency. We have examined the capacity of newly described retroviral vectors based on the gibbon ape leukemia virus (GaLV) to introduce genes into human hematopoietic progenitor cells. Total nucleated human bone marr
HIV-1 gp120 modulates hypothalamic cytokine mRNAs in vivo: implications to cytokine feedback systems.: Biochem Biophys Res Commun. 1997 Feb 13;231(2):514-8. Unique Identifier : AIDSLINE MED/97223490; Ilyin SE; Plata-Salaman CR; Division of Molecular Biology, School of Life and Health Sciences,; University of Delaware, Newark 19716-2590, USA.; HIV-1-derived envelope glycoprotein 120 (gp120) may play an important role in HIV-1 neuropathology. Gp120 may act through mediators including proinflammatory cytokines. Here, we investigated the regulation of the IL-1 beta system [IL-1 beta, IL-1 receptor type I (IL-1RI), IL-1 receptor antagonist (IL-1Ra), IL-1 recept
The hepatitis B virus posttranscriptional regulatory element contains a highly stable RNA secondary structure.: Biochem Biophys Res Commun. 1997 Feb 24;231(3):864-7. Unique Identifier : AIDSLINE MED/97224451; Patzel V; Sczakiel G; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.; Hepatitis B virus (HBV) transcripts contain a sequence known as the posttranscriptional regulatory element (PRE). This element was shown to facilitate the nuclear export of the S gene transcripts, to partially substitute for the human immunodeficiency virus (HIV-1) Rev-response element (RRE), and to bind two cellular
Superantigen as a modifying factor in HIV infection.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):143-54. Unique Identifier : AIDSLINE MED/97229613; Kobayashi N; Urasawa S; Department of Hygiene, Sapporo Medical University School of Medicine,; Japan.; Superantigen is characterized as a potent stimulator of T cells through its unique interaction with major histocompatibility complex class II molecule and the V beta chain of T cell receptor. It has been reported that symptoms in several infectious diseases are associated with superantigen activity, i.e., abnormal rea
Outcome and survival in HIV-infected infants with Pneumocystis carinii pneumonia and respiratory failure.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):155-63. Unique Identifier : AIDSLINE MED/97229614; Sheikh S; Bakshi SS; Pahwa SG; Department of Pediatrics, North Shore University Hospital, Manhasset,; New York 10030, USA.; A retrospective chart review (January 1987-December 1994) of cases of histologically proven Pneumocystis carinii pneumonia PCP) in 9 infants (ages 1.1-7 months) who had perinatally acquired human immunodeficiency-1 virus (HIV) infection was performed. None of the children was suspected of having HIV or had received PC
Diagnosis of perinatally acquired HIV-1 infection using an IgA ELISA test.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):164-7. Unique Identifier : AIDSLINE MED/97229615; Liberatore D; Avila MM; Calarota S; Libonatti O; Martinez Peralta L; Department of Microbiology, University of Buenos Aires School of; Medicine, Argentina.; The clinical utility of the detection of anti-HIV-1 IgA antibodies using a modified commercial ELISA (EIA) test for the early diagnosis of perinatally acquired HIV-1 infection was evaluated. One hundred and seventeen sera were obtained from 86 infants born to HIV-1-infected mothers and tested for HIV IgA antibodies by
Family-centered care: a paradigm for care of the HIV-affected family.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):168-75. Unique Identifier : AIDSLINE MED/97229616; Brady MT; Crim L; Caldwell L; Koranyi K; Department of Pediatrics, College of Medicine, Ohio State University,; USA.
Attitudes and practices of physicians caring for HIV-infected children.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):176-81. Unique Identifier : AIDSLINE MED/97229617; Siegel RM; Rosenthal SL; Hill TD; Baker RC; Department of Pediatrics, St. Luke Hospital, Fort Thomas, Kentucky; 41073, USA.; OBJECTIVE: The objective of our study was to describe the practices and attitudes of physicians who manage children with HIV infection. METHODS: A 32-question survey was sent to the medical directors of 256 pediatric HIV centers. RESULTS: Fifty-four percent of centers responded. Seventy-two percent of practitioners ha
From the Food and Drug Administration. New tuberculosis test approved.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):224. Unique Identifier : AIDSLINE MED/97229618
From the National Center for Research Resources. Pigtailed macaques: a promising model for AIDS research.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):225-6. Unique Identifier : AIDSLINE MED/97229619
From the Agency for Health Care Policy Research (AHCPR). HIV/AIDS research. Primary care physicians often fail to recognize important signs of HIV infection.: Pediatr AIDS HIV Infect. 1996 Jun;7(3):227-31. Unique Identifier : AIDSLINE MED/97229620
Preclinical data on the antiretroviral activity of AZT [editorial]: Aids Patient Care STDS. 1996 Aug;10(4):208-9. Unique Identifier : AIDSLINE MED/97229536; Laurence J
Open heart surgery in an HIV-positive patient.: Aids Patient Care STDS. 1996 Aug;10(4):210-2. Unique Identifier : AIDSLINE MED/97229537; Christian F Jr; Song J; Bhatnagar B; Wittenborn W; Rosario PG; Department of Cardiothoracic Surgery, UMDNJ, New Jersey Medical; School, Newark, USA.
The role of the FDA in drug development: implications for improved access to new HIV/AIDS therapies. Testimony before the Subcommittee on Health and Environment-Committee on Commerce concerning FDA reform bill HR 3199.: Aids Patient Care STDS. 1996 Aug;10(4):213-20. Unique Identifier : AIDSLINE MED/97229538; Cooper EC; Sanders S; Department of Clinical Research and Information, American Foundation; for AIDS Research, USA.
Update on chancroid: an important cause of genital ulcer disease.: Aids Patient Care STDS. 1996 Aug;10(4):221-6. Unique Identifier : AIDSLINE MED/97229539; Langley C; Division of STD/HIV at the Mississippi State Department of Health,; Jackson, USA.; Chancroid is a major cause of genital ulcer disease worldwide, and occurred at epidemic rates in the United States in the late 1980s. Though the recent epidemic in the U.S. appears to be waning, a number of areas continue to report significant numbers of cases. Chancroid is a particula
Primary care physicians and their HIV prevention practices.: Aids Patient Care STDS. 1996 Aug;10(4):227-35. Unique Identifier : AIDSLINE MED/97229540; Kerr SH; Valdiserri RO; Loft J; Bresolin L; Holtgrave D; Moore M; MacGowan R; Marder W; Rinaldi R; Centers for Disease Control and Prevention, Atlanta, GA, USA.; A national random-sample survey of 4011 primary care physicians was conducted to determine the extent to which they are providing HIV prevention and clinical services, and to learn what characteristics and attitudes might impede the provision of such services. Physicians were asked about their history-taking practices
Quality-of-life issues in individuals with HIV disease: an occupational therapy perspective.: Aids Patient Care STDS. 1996 Aug;10(4):236-9. Unique Identifier : AIDSLINE MED/97229541; Chan RS; Gorga D; Ilaria G; Damson L; Jacobs JL; Center for Special Studies, New York Hospital/Cornell University; Medical Center, NY, USA.
A model for the delivery of care for HIV-positive clients.: Aids Patient Care STDS. 1996 Aug;10(4):240-5. Unique Identifier : AIDSLINE MED/97229542; Dykeman MC; Sternberg C; Jasek J; McGee DS; Driscoll M; Cohen V; Lubin B; Williamson M; Cohen M; Sherer R; Cook County HIV Primary Care Center, Cook County Hospital, Chicago,; IL., USA.
Risperidone for AIDS-associated dementia: a case series.: Aids Patient Care STDS. 1996 Aug;10(4):246-9. Unique Identifier : AIDSLINE MED/97229543; Belzie LR; Linroc Nursing Home, Brookdale Medical Center, Brooklyn, NY, USA.; OBJECTIVE: To determine the effect of low-dose risperidone on behavioral disturbances associated with AIDS dementia in young-to-middle-age nursing home patients. Neuroleptics are commonly used for behavioral control in this population, but these drugs often fail to control symptoms
Self-appraised health, HIV infection, and depression in female clients of AIDS counseling centers.: Aids Patient Care STDS. 1996 Aug;10(4):250-7. Unique Identifier : AIDSLINE MED/97229544; Linn JG; Anema MG; Estrada JJ; Cain VA; Sharpe CP; School of Nursing, Tennessee State University, USA.; The development of effective coping strategies may require that women and men with HIV have an accurate, and to the greatest extent possible, positive, perception of their own health status. This has been found to be lacking among HIV-infected persons with limited education/information, including many minority adults.
HIV/AIDS case histories: diagnostic problems. Disseminated histoplasma capsulatum infection.: Aids Patient Care STDS. 1996 Aug;10(4):258. Unique Identifier : AIDSLINE MED/97229545; Godwin JH; LaSala J; Cornell University Medical College.
Public policy update: an AmFAR report.: Aids Patient Care STDS. 1996 Aug;10(4):259-60. Unique Identifier : AIDSLINE MED/97229546; Silver J
Expanded access for delvaridine [news]: Aids Patient Care STDS. 1996 Aug;10(4):261. Unique Identifier : AIDSLINE MED/97229548
Revision of ritonavir starting dose [news]: Aids Patient Care STDS. 1996 Aug;10(4):261. Unique Identifier : AIDSLINE MED/97229549
Saquinavir combination results released [news]: Aids Patient Care STDS. 1996 Aug;10(4):261. Unique Identifier : AIDSLINE MED/97229547
Smaller tablet for Videx [news]: Aids Patient Care STDS. 1996 Aug;10(4):261. Unique Identifier : AIDSLINE MED/97229550
AIDS treatments seek to eradicate virus, restore immunity [news]: Aids Patient Care STDS. 1996 Aug;10(4):261-2. Unique Identifier : AIDSLINE MED/97229551
Glaxo Wellcome expands Patient Assistance Program for 3TC [news]: Aids Patient Care STDS. 1996 Aug;10(4):262. Unique Identifier : AIDSLINE MED/97229552
DaunoXome approved [news]: Aids Patient Care STDS. 1996 Aug;10(4):263. Unique Identifier : AIDSLINE MED/97229554
Immune enhancement trial begins [news]: Aids Patient Care STDS. 1996 Aug;10(4):263. Unique Identifier : AIDSLINE MED/97229553
Thalidomide trial for diarrhea [news]: Aids Patient Care STDS. 1996 Aug;10(4):263. Unique Identifier : AIDSLINE MED/97229555
Viron data released [news]: Aids Patient Care STDS. 1996 Aug;10(4):263-4. Unique Identifier : AIDSLINE MED/97229556
Hyperthermia trials expand [news]: Aids Patient Care STDS. 1996 Aug;10(4):264. Unique Identifier : AIDSLINE MED/97229557
Low-dose oral alpha interferon study opens [news]: Aids Patient Care STDS. 1996 Aug;10(4):264. Unique Identifier : AIDSLINE MED/97229558
AIDS and electronic communications news.: Aids Patient Care STDS. 1996 Aug;10(4):267-8. Unique Identifier : AIDSLINE MED/97229559; Makulowich JS; john@trainer.com
Attitude of emergency department patients toward HIV-infected health care workers.: Am J Emerg Med. 1997 Mar;15(2):141-4. Unique Identifier : AIDSLINE MED/97249038; Salluzzo RF; Bartfield JM; Freed H; Graber M; Peters T; Department of Emergency Medicine, Albany Medical Center, NY 12208,; USA.; A telephone survey of a random sample of adult emergency department (ED) patients was conducted at a university health science center. The purpose of the study was to determine the opinion of ED patients concerning the risk of human immunodeficiency virus (HIV) transmission and their willingness to be treated by HIV-i
Increased numbers of in vivo activated T cells in patients with recent onset insulin-dependent diabetes mellitus.: J Autoimmun. 1996 Dec;9(6):731-7. Unique Identifier : AIDSLINE MED/97165558; Petersen LD; Duinkerken G; Bruining GJ; van Lier RA; de Vries RR; Roep BO; Department of Immunohaematology & Blood Bank, University Hospital; Leiden, The Netherlands.; Insulin-dependent diabetes mellitus is a T-cell dependent immune mediated disease. Conflicting results regarding the distribution of various T lymphocyte phenotypes in recently diagnosed diabetic patients and in patients with established IDDM compared to controls have been reported. In the present study we evaluated p
HIV transmission by transplantation of allograft skin: a review of the literature.: Burns. 1997 Feb;23(1):1-5. Unique Identifier : AIDSLINE MED/97167993; Pirnay JP; Vandenvelde C; Duinslaeger L; Reper P; Vanderkelen A; Burn Center, Military Hospital, Brussels, Belgium.; The fear of human immunodeficiency virus (HIV) transmission by means of allograft skin has led to a cautious approach to allograft donor selection. However, no irrefutable diagnostic test exists to determine the possible presence of HIV at the time of donation. In order to find ways of improving HIV donor screening pr
An amperometric enzyme-channeling immunosensor.: Biosens Bioelectron. 1997;12(3):195-204. Unique Identifier : AIDSLINE MED/97222597; Rishpon J; Ivnitski D; Department of Molecular Microbiology & Biotechnology, Tel-Aviv; University, Israel. Rishpon@post.TAU.AC.IL; This paper presents a new disposable amperometric, enzyme-channeling immunosensor for a quantitative, rapid, separation-free enzyme immunoassay (EIA) that can be used in clinical diagnostics, as well as in biomedical, biochemical, and environmental research. The sensor consists of a disposable, polymer-modified, carbo
Antitumour and anti-AIDS triterpenes from Celastrus hindsii.: Phytochemistry. 1997 Apr;44(7):1275-81. Unique Identifier : AIDSLINE MED/97235591; Kuo YH; Kuo LM; National Research Institute of Chinese Medicine, Taipei, Taiwan,; R.O.C.; Four new triterpene compounds, celasdin-A, celasdin-C, anti-AIDS celasdin-B and cytotoxic maytenfolone-A, were isolated from Celastrus hindsii. The structural determination of maytenfolone-A, celasdin-A, celasdin-B and celasdin-C, as well as the structure-activity relationships of these new compounds and derivatives,
Mediation of entry of human immunodeficiency virus-1 into alveolar macrophages by CD4 without facilitation by surfactant-associated protein-A.: Am J Respir Cell Mol Biol. 1997 Apr;16(4):421-8. Unique Identifier : AIDSLINE MED/97246490; Guay LA; Sierra-Madero JG; Finegan CK; Rich EA; Department of Pediatrics, Case Western Reserve University, Cleveland,; Ohio 44106-4984, USA.; The mechanism of uptake of human immunodeficiency virus-1 (HIV-1) into alveolar macrophages (AM), freshly isolated blood monocytes MN), and cultured MN (CM) was investigated focusing on the role of CD4 and of surfactant-associated protein A (SP-A). By radioimmunoassay which obviated the problems of auto- and nonspecif
Alveolar macrophages produce the Env protein of a human endogenous retrovirus, HERV-E 4-1, in a subgroup of interstitial lung diseases.: Am J Respir Cell Mol Biol. 1997 Apr;16(4):429-37. Unique Identifier : AIDSLINE MED/97246491; Tamura N; Iwase A; Suzuki K; Maruyama N; Kira S; Department of Respiratory Medicine, Juntendo University School of; Medicine, Bunkyo-ku, Tokyo, Japan.; We investigated whether intraalveolar inflammatory cells such as alveolar macrophages or lymphocytes produced the gene product of a type-C human endogenous retrovirus (HERV), HERV-E 4-1, which might initiate an immune response resulting in interstitial lung disease. We evaluated HERV-E 4-1 Env protein production by br
Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones.: Am J Respir Cell Mol Biol. 1997 Apr;16(4):448-54. Unique Identifier : AIDSLINE MED/97246493; Kaminuma O; Mori A; Ogawa K; Nakata A; Kikkawa H; Naito K; Suko M; Okudaira H; Department of Medicine and Physical Therapy, University of Tokyo,; Japan.; Bronchial asthma is characterized by chronic eosinophilic inflammation of the bronchial mucosa. Accumulating evidences suggest that activated T cells and T cell cytokines play critical roles in the local accumulation and activation of eosinophils. To further delineate the critical role of T cells on asthma, we tested
HIV type 1 vaccine-induced cytotoxic T cell responses: potential role in vaccine efficacy.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):205-10. Unique Identifier : AIDSLINE MED/97186410; Ada GL; McElrath MJ; Division of Immunology and Cell Biology, John Curtin School of Medical; Research, Australian National University, Canberra, Australia.
HIV type 1 vaccine-induced cytotoxic T cell responses in phase I clinical trials: detection, characterization, and quantitation.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):211-6. Unique Identifier : AIDSLINE MED/97186411; McElrath MJ; Siliciano RF; Weinhold KJ; Department of Medicine, University of Washington School of Medicine,; Seattle 98144, USA.
Increased plasma HIV type 1 RNA levels are associated with low levels of non-MHC class I-restricted cytotoxicity [letter]: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):217-8. Unique Identifier : AIDSLINE MED/97186412; Ullum H; Katzenstein T; Gerstoft J; Skinhoj P; Klarlund Pedersen B
HIV type 1 V3 peptide constructs act differently on HIV type 1 infection of peripheral blood lymphocytes and macrophages.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):219-26. Unique Identifier : AIDSLINE MED/97186413; Benjouad A; Seddiki N; Ylisastigui L; Gluckman JC; Laboratoire de Biologie et Genetique des Deficits Immunitaires, CERVI,; Hopital de la Pitie-Salpetriere, Paris, France.; We have previously shown that a multibranched peptide construct derived from the tip of the B clade V3 loop consensus sequence MPBC1: [GPGRAF]8-[K]4-[K]2-K-beta A-OH), but not V3 monomer peptides, inhibit human immunodeficiency virus type 1 (HIV-1) infection and syncytium formation of CD4+ T cells from immortalized li
Expression of granzyme B by cytotoxic T lymphocytes in the lymph nodes of HIV-infected patients.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):227-33. Unique Identifier : AIDSLINE MED/97186414; Koopman G; Wever PC; Ramkema MD; Bellot F; Reiss P; Keehnen RM; Ten Berge IJ; Pals ST; Department of Pathology, Academic Medical Center, Amsterdam, The; Netherlands.; During HIV infection the architecture of secondary lymphoid tissues is severely disrupted. In particular the germinal centers, which play a key role in the orchestration of the secondary immune response, undergo gross phenotypic alterations, leading to a complete destruction of the germinal center microenvironment. Th
NF-kappa B-independent suppression of HIV expression by ascorbic acid.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):235-9. Unique Identifier : AIDSLINE MED/97186415; Harakeh S; Jariwalla RJ; Linus Pauling Institute of Science and Medicine, Palo Alto, California; 94306, USA.; Ascorbic acid (ascorbate or vitamin C) has been shown to suppress the induction of HIV in latently infected T lymphocytic cells following stimulation with a tumor promoter (PMA) and inflammatory cytokine (TNF-alpha). To assess whether this inhibition was mediated via modulation of the cellular transcription factor, NF
Early treatment with 9-(2-phosphonylmethoxyethyl)adenine reduces virus burdens for a prolonged period in SIV-infected rhesus macaques.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):241-6. Unique Identifier : AIDSLINE MED/97186416; Joag SV; Li Z; Foresman L; Pinson DM; Stephens EB; Raghavan R; Nave JF; Casara P; Narayan O; Marion Merrell Dow Laboratory of Viral Pathogenesis, University of; Kansas Medical Center, Kansas City 66160, USA.; We evaluated the effects of a reverse transcriptase inhibitor, 9-(2-phosphonylmethoxyethyl)adenine (PMEA), on simian immunodeficiency virus (SIV) infection in rhesus macaques (Macaca mulatta). Four macaques were given PMEA (20 mg/kg) subcutaneously on days 1 and 2 and inoculated with virus on day 2. Drug treatment was
Gross defects in the vpr and vpu genes of HIV type 1 cannot explain the differences in RNA copy number between long-term asymptomatics and progressors.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):247-52. Unique Identifier : AIDSLINE MED/97186417; Cornelissen M; Kuiken C; Zorgdrager F; Hartman S; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre, Amsterdam,; The Netherlands.; Disease progression in HIV-1-infected individuals is strongly associated with persistent and high numbers of HIV-1 RNA copies. We previously reported a markedly lower viral RNA load in eight long-term asymptomatics (LTAs) compared to seven matched progressors (at 1 year after seroconversion or entry in the study, p
Stability of HIV type 1 proviral genomes that contain two distinct primer-binding sites.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):253-62. Unique Identifier : AIDSLINE MED/97186418; Li Y; Kang SM; Morrow CD; Department of Microbiology, University of Alabama at Birmingham 35294,; USA.; The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs by the extension of a tRNALys,3 positioned at an 18-nucleotide sequence in the RNA genome referred to as the primer-binding site (PBS). We have found that mutations within the PBS and a region upstream in U5, designated the A lo
Calmodulin-binding function of LLP segments from the HIV type 1 transmembrane protein is conserved among natural sequence variants.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):263-9. Unique Identifier : AIDSLINE MED/97186419; Tencza SB; Mietzner TA; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; LLP1 is a peptide, derived from the cytoplasmic tail of HIV-1 TM glycoprotein, that binds and inhibits calmodulin; this region is generally conserved among isolates, but amino acid variation does exist both within clade B and among different clades, as well as SIV. In light of previous studies showing that selected si
A characteristic change of consensus core motif in the V3 region of HIV type 1 clade B, but not in clade E, in Thailand.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):271-3. Unique Identifier : AIDSLINE MED/97186420; Naganawa S; Na Ayuttaya PI; Duangchanda S; Auwanit W; Warachit P; Miyamura K; Yamazaki S; Honda M; Thai AIDS Project, Department of Medical Sciences, Ministry of Public; Health, Nonthaburi, Thailand.
HIV type 1 V3 loop sequences derived from peripheral blood of transmitting mothers, their infants, and nontransmitting mothers differ in their crown octapeptide motifs.: AIDS Res Hum Retroviruses. 1997 Feb 10;13(3):275-9. Unique Identifier : AIDSLINE MED/97186421; Wang B; Ge YC; Palasanthiran P; Ziegler J; Bolton W; Xiang SH; Dwyer DE; Cunningham AL; Saksena NK; Retroviral Genetics Laboratory, Westmead Institute for Health; Research, Westmead Hospital, NSW, Sydney, Australia.
[Anal epidermoid carcinoma: a rare incidence or a rare diagnosis?]: Rev Esp Enferm Dig. 1997 Feb;89(2):128-32. Unique Identifier : AIDSLINE MED/97241575; Prieto Reyes M; Vazquez Marquez L; Unidad de Proctologia, Hospital Universitario Reina Sofia, Cordoba.; Epidermoid cancer of the anus is a rare entity which represents 1-2% of all gastrointestinal tract cancers. Possible predisposing causes include smoking and sexual behaviour, particularly homosexual anal intercourse, chronic inflammation (Crohn, anal fistula, fissure, sepsis, hydradenitis suppurativa), and transmissib
[Intestinal leishmaniasis in AIDS patients (letter)]: Rev Esp Enferm Dig. 1997 Feb;89(2):145. Unique Identifier : AIDSLINE MED/97241581; Garcia-Samaniego J; Laguna F
Oral lesions in Thai heterosexual AIDS patients: a preliminary study.: Br Dent J. 1997 Mar 22;182(6):219-21. Unique Identifier : AIDSLINE MED/97261032; Nittayananta W; Jealae S; Chungpanich S; Faculty of Dentistry, Prince of Songkla University, Haadyai, Songkhla,; Thailand.; OBJECTIVE: To study the types of oral lesions in Thai heterosexual AIDS patients. DESIGN: Cross-sectional study and single centre. SETTING: Medical ward of the Prince of Songkla University Hospital, Thailand , from June 1994 to May 1995. SUBJECTS: Heterosexual AIDS patients who ha
Lifting injury: a study of the occupational health perspective.: Nurs Stand. 1997 Mar 19;11(26):33-8. Unique Identifier : AIDSLINE MED/97257829; Love C; Bloomsbury and Islington College of Nursing and Midwifery.; This article reports the results of a national questionnaire survey of 66 occupational health staff regarding the circumstances of nurse injury. Eight causative factors were identified as either a frequent direct cause or major contributory factor. Three circumstances were identified when nurses are most at risk of in
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone.: Biochemistry. 1997 Mar 18;36(11):3179-85. Unique Identifier : AIDSLINE MED/97228090; Borkow G; Fletcher RS; Barnard J; Arion D; Motakis D; Dmitrienko GI; Parniak MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.; HIV-1 reverse transcriptase (RT) is multifunctional, with RNA-dependent DNA polymerase (RDDP), DNA-dependent DNA polymerase DDDP), and ribonuclease H (RNase H) activities. N-(4-tert-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone BBNH) inhibited both the polymerase and the RNase H activities of HIV-1 RT in vitro. I
HIV expression is induced in dying cells.: Biochim Biophys Acta. 1997 Mar 20;1351(1-2):105-10. Unique Identifier : AIDSLINE MED/97236436; Woloschak GE; Schreck S; Panozzo J; Chang-Liu CM; Libertin CR; Center for Mechanistic Biology and Biotechnology, Argonne National; Laboratory, IL 60439-4833, USA. woloschak@anl.gov; Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. gamma rays were the only cell-killing agent which did not induce HIV transcription; t
Sex and travel: studies of sexual behaviour, disease and health promotion in international travellers--a global review [editorial]: Int J STD AIDS. 1996 Nov-Dec;7(7):455-65. Unique Identifier : AIDSLINE MED/97157709; Mulhall BP; Sexually transmitted diseases (STDs) continue to be the most common notifiable infectious conditions worldwide. Their unacceptably high incidence is underlined by the recent emergence of a (presently) incurable and lethal STD--human immunodeficiency virus (HIV) infection--which merits its description as a pandemic, an
Management and treatment of Kaposi's sarcoma in AIDS. The Jefferiss Wing Therapeutics and Protocols Group.: Int J STD AIDS. 1996 Nov-Dec;7(7):466-70. Unique Identifier : AIDSLINE MED/97157710; Tomlinson DR; Coker RJ; Fisher M
The prostatitis syndromes.: Int J STD AIDS. 1996 Nov-Dec;7(7):471-8. Unique Identifier : AIDSLINE MED/97157711; Luzzi G; Department of Genitourinary Medicine, Wycombe General Hospital, UK.
The prevalence of previous sexual assault among routine female attenders at a department of genitourinary medicine.: Int J STD AIDS. 1996 Nov-Dec;7(7):480-4. Unique Identifier : AIDSLINE MED/97157712; Keane FE; Young SM; Boyle HM; Department of Genitourinary Medicine, Leicester Royal Infirmary, UK.; One hundred and fifty women who attended the routine genitourinary medicine (GUM) clinic at the Leicester Royal Infirmary (LRI) between August 1993 and February 1994 completed a questionnaire enquiring into a past history of sexual assault. Of these, 52 (34.7%) confirmed that they had been assaulted previously, 18 bel
Antioxidant-micronutrients and HIV inf