1997

HHV-8 is associated with recurrent Kaposi's sarcoma in a renal transplant recipient [letter]: Transpl Int. 1997;10(1):81-2. Unique Identifier : AIDSLINE MED/97155459; Noel JC; De Thier F; Heenen M; Fayt I; Abramowicz D; Doutrelepont JM
In vitro and in vivo tumor growth suppression by HIV-1 Vpr.: DNA Cell Biol. 1997 Feb;16(2):137-43. Unique Identifier : AIDSLINE MED/97205230; Mahalingam S; MacDonald B; Ugen KE; Ayyavoo V; Agadjanyan MG; Williams WV; Weiner DB; Department of Medical Microbiology and Immunology, University of South; Florida College of Medicine, Tampa 33612, USA.; We have previously reported that the human immunodeficiency virus type 1 (HIV-1) regulatory gene vpr induces differentiation of rhabdomyosarcoma (embryonal muscle tumor cell line) cells, an effect that is accompanied by reduced proliferative capacity of the transfected cells. In this report, we examine the effect of V
Role of viral infections in the induction of adverse drug reactions.: Drug Saf. 1997 Jan;16(1):1-8. Unique Identifier : AIDSLINE MED/97163885; Levy M; Department of Medicine, Hadassah University Hospital, Ein Karem,; Jerusalem, Israel.; A spectrum of adverse drug reactions that are caused by the combined action of drugs and viruses has been described: ampicillin rash in acute infectious mononucleosis; Reye s syndrome; hypersensitivity reactions to sulphonamides in patients with HIV infection; drug-induced agranulocytosis; paracetamol acetaminophen) h
Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma).: Curr Opin Immunol. 1997 Feb;9(1):17-23. Unique Identifier : AIDSLINE MED/97192250; Trinchieri G; The Wistar Institute of Anatomy and Biology, 3601 Spruce Street,; Philadelphia, PA 19104, USA. trinchieri@wista.wistar.upenn.edu; The three cytokines IL-12, IL-10, and IFN-gamma have important and cross-regulatory roles in infection. In the past year, much progress has been made in the understanding of the cellular and molecular mechanisms involved in the regulation (and cross-regulation) of these three cytokines and their role in pathology. IL-
Changing care: evidence-based decisions in HIV and cytomegalovirus therapy. Proceedings of a satellite symposium to the XI International Conference on AIDS. Vancouver, Canada, 7 July 1996.: AIDS. 1996 Nov;10 Suppl 1:S1-49. Unique Identifier : AIDSLINE MED/97227880
Rational approaches to resistance: using saquinavir.: AIDS. 1996 Nov;10 Suppl 1:S15-9. Unique Identifier : AIDSLINE MED/97125599; Boucher C; Department of Virology, Eykman-Winkler Institute, University Hospital; Utrecht, The Netherlands.; AIM: To review drug-resistance patterns of HIV protease inhibitors , with particular reference to saquinavir, and how resistance and cross-resistance patterns may influence disease management. RESISTANCE TO SAQUINAVIR: Resistance to saquinavir in vitro and in vivo is
Risks and synergies from drug interactions.: AIDS. 1996 Nov;10 Suppl 1:S21-5. Unique Identifier : AIDSLINE MED/97125600; Sahai J; Clinical Investigation Unit, Ottawa General Hospital, Ontario, Canada.; AIM: To review what is known from in vitro and in vivo studies about the interactions, both potentially beneficial and potentially harmful, of antiretroviral agents with each other and with other classes of drugs. INTERACTIONS WITH NUCLEOSIDE ANALOGUES: Some interactions between nucleoside HIV reverse transcriptase in
Changing therapy in HIV.: AIDS. 1996 Nov;10 Suppl 1:S27-30. Unique Identifier : AIDSLINE MED/97125601; Lange JM; NATEC, Academic Medical Centre, University of Amsterdam, The; Netherlands.; AIM: To review recent developments in research into HIV and antiretroviral therapy and how these developments have affected the monitoring and treatment of HIV infection. DEVELOPMENTS AND THEIR IMPLICATIONS: More antiretroviral agents of different types have become available over recent years;
What we know so far.: AIDS. 1996 Nov;10 Suppl 1:S3-7. Unique Identifier : AIDSLINE MED/97125597; Gazzard B; Chelsea and Westminster Hospital, London, UK.; AIM: To review current knowledge of anti-HIV therapy and the implications for patient management. WHAT IS KNOWN: In three large clinical studies, combination therapy with zidovudine plus didanosine or zalcitabine improved survival and delayed clinical events in compari
Lessons learned from HIV pathogenesis and therapy: implications for better management of cytomegalovirus disease.: AIDS. 1996 Nov;10 Suppl 1:S31-5. Unique Identifier : AIDSLINE MED/97125602; Hardy WD; Center for Clinical AIDS Research and Education, UCLA School of; Medicine, USA.; AIM: To review how developments in virological quantitation technology have altered our understanding of the pathogenesis of HIV infection, and the way in which we treat the disease, and to consider how we may apply this type of knowledge to improve the management of cytomegalovirus
Lessons from the natural history of cytomegalovirus.: AIDS. 1996 Nov;10 Suppl 1:S37-41. Unique Identifier : AIDSLINE MED/97125603; Bowen EF; Griffiths PD; Davey CC; Emery VC; Johnson MA; Department of Virology, Royal Free Hospital, London, UK.; BACKGROUND: More than 90% of patients with HIV have been infected at some time with cytomegalovirus ( CMV ) and up to 40% of those with advanced HIV will develop CMV disease. The incidence of CMV disease is increasing but the p
Consequences for the management of cytomegalovirus.: AIDS. 1996 Nov;10 Suppl 1:S43-6. Unique Identifier : AIDSLINE MED/97125604; Katlama C; Groupe Hospitalier Pitie-Salpetriere, Paris, France.; BACKGROUND: Recent advances in the field of antiretroviral therapy have led to a new era where it is possible to effectively prolong the survival of HIV-infected patients. However, a corollary is the increasing prevalence of opportunistic infections, such as cytomegalovirus (
Rational approaches to resistance: nucleoside analogues.: AIDS. 1996 Nov;10 Suppl 1:S9-13. Unique Identifier : AIDSLINE MED/97125598; Mayers D; Walter Reed Army Institute of Research, Rockville, Maryland, USA.; AIM: To review knowledge of drug-resistance patterns to nucleoside HIV reverse transcriptase inhibitors and how this can be used to advantage in patient management. PATTERNS OF RESISTANCE: The speed of emergence of HIV-1 drug resistance is dependent on host, viral and drug factors. Resistance to zidovudine develops ov
Update on the issues of HIV vaccine development.: Ann Med. 1996 Feb;28(1):39-41. Unique Identifier : AIDSLINE MED/97086310; Haynes BF; Putman SB; Weinberg JB; Duke University Arthritis Center, Duke University School of Medicine,; Durham, NC 27710, USA.; Major scientific obstacles blocking the development of a successful preventive HIV vaccine are the extraordinary variability of HIV, the lack of an exact animal model of HIV-induced AIDS, and the lack of understanding of the correlates of positive immunity to HIV. Current HIV vaccines containing the HIV gp120 envelope
Quantification of HIV-1 using multiple competitors in a single-tube assay.: Biotechniques. 1996 Aug;21(2):248-52, 253-5. Unique Identifier : AIDSLINE MED/97016172; Vener T; Axelsson M; Albert J; Uhlen M; Lundeberg J; KTH, Royal Institute of Technology, Swedish Institute for Infectious; Disease Control, Stockholm, Sweden.; Methods for quantification of human immunodeficiency virus type 1 HIV-1) based on competitive PCR and fragment analysis have been developed. Samples containing HIV-1 DNA and known amounts of three cloned competitors were co-amplified by PCR with semi-nested primers. The competitor DNAs contained the same long terminal
Use of flow cytometry and RT-PCR for detecting gene expression by single cells.: Biotechniques. 1996 Aug;21(2):286-91. Unique Identifier : AIDSLINE MED/97016177; Gaynor EM; Mirsky ML; Lewin HA; University of Illinois at Urbana-Champaign, USA.; We have developed a method for reliably detecting gene expression by individual, phenotypically defined cells. Cells were sorted by flow cytometry into 96-well plates containing a Nonidet P-40 NP40)-based bysis solution. Reverse transcription (RT) of cellular major histocompatibility complex class II DQB and either bo
Direct amplification and cloning of up to 5-kb lentivirus genomes from serum.: Biotechniques. 1996 Aug;21(2):312-9. Unique Identifier : AIDSLINE MED/97016181; Holterman L; Mullins JI; Haaijman JJ; Heeney JL; Biomedical Primate Research Centre, Rijswijk, The Netherlands.; To produce large cDNA strands from biological samples containing limited numbers of template molecules, it may be necessary to minimize both nonspecific primer attachment in first-strand synthesis and secondary structure in RNA molecules. Failure to do so could result in the accumulation of shortened cDNA strands and
Regulator and effector functions of T-cell subsets in human Leishmania infections.: APMIS Suppl. 1997;68:1-33. Unique Identifier : AIDSLINE MED/97217472; Kemp M; Centre for Medical Parasitology, University of Copenhagen.; Because of an increasing number of patients suffering from Leishmania infections and because of the serious consequences of these infections more thorough knowledge of the host factors responsible for resistance and susceptibility to the diseases is needed. In murine models of Leishmania infections the cytokine produc
Sonographic measurement of thymic size in healthy neonates. Relation to clinical variables.: Acta Radiol. 1997 Jan;38(1):95-8. Unique Identifier : AIDSLINE MED/97212553; Hasselbalch H; Jeppesen DL; Ersboll AK; Lisse IM; Nielsen MB; Department of Radiology, Hvidovre Hospital, Copenhagen, Denmark.; PURPOSE: To assess the variation in thymic size in healthy neonates by sonography and to study the possible correlation to clinical variables. MATERIAL AND METHODS: A study was made of 149 healthy term infants, at less than one week of age. The size of the thymus was assessed by sonography as a volume estimate, the th
The transition from underground to legal syringe exchange: the New York City experience.: AIDS Educ Prev. 1996 Dec;8(6):471-89. Unique Identifier : AIDSLINE MED/97163701; Kochems LM; Paone D; Des Jarlais DC; Ness I; Clark J; Friedman SR; Chemical Dependency Institute, Beth Israel Medical Center, New York,; NY 10003, USA.; The most common method of syringe exchange program (SEP) development in the United States has been for SEPs to be started by activists without funding and then to become a government-funded community-based organization. This developmental process, which has not been studied to date, in
Multiple sexual partners and condom use among long-distance truck drivers in Thailand.: AIDS Educ Prev. 1996 Dec;8(6):490-8. Unique Identifier : AIDSLINE MED/97163702; Podhisita C; Wawer MJ; Pramualratana A; Kanungsukkasem U; McNamara R; Institute for Population and Social Research, Mahidol University,; Bangkok, Thailand.; Sexual behaviors of long-distance truck drivers in Thailand were investigated to define patterns and determinants critical to the transmission of HIV. This article reports on commercial, spousal, and other sexual partners and on condom use among 327 drivers interviewed in 1992. F
Predictors of African American adolescents' condom use and HIV risk behavior.: AIDS Educ Prev. 1996 Dec;8(6):499-515. Unique Identifier : AIDSLINE MED/97163703; Reitman D; St. Lawrence JS; Jefferson KW; Alleyne E; Brasfield TL; Shirley A; Jackson State University, MS 39217-0105, USA.; This study evaluated predictors of risky and safer behavior in a sample of low-income African American adolescents, assessed their perceptions of the risk associated with their sexual behavior, and examined differences between adolescents who used condoms consistently, inconsistently, or engaged only in unprotected in
Effects of an institutional AIDS prevention intervention: moderation by gender.: AIDS Educ Prev. 1996 Dec;8(6):516-28. Unique Identifier : AIDSLINE MED/97163704; O'Leary A; Jemmott LS; Goodhart F; Gebelt J; Department of Psychology, Rutgers University, New Brunswick, NJ 08903,; USA.; AIDS risk reduction programs are being conducted in many institutional settings, but rigorous evaluations of their effectiveness are lacking. This is particularly unfortunate in that these programs are expensive, and tend to be of lower intensity than those that have been shown to be effective. Further, risk reduction
HIV seropositive gay men: understanding adoption of safe sexual practices.: AIDS Educ Prev. 1996 Dec;8(6):529-45. Unique Identifier : AIDSLINE MED/97163705; Godin G; Savard J; Kok G; Fortin C; Boyer R; L'Ecole des sciences infirmieres, Universite Laval, Ste-Foy, Quebec,; Canada.; The aim of this study was to determine the best predictors of safe sex practices among HIV seropositive gay men. A group of 96 homosexual men living with HIV completed a questionnaire that investigated theoretical constructs of the Ajzen s (1988) theory of planned behavior with respect to condom use for anal intercour
Differences between gay men in primary relationships and single men: implications for prevention.: AIDS Educ Prev. 1996 Dec;8(6):546-59. Unique Identifier : AIDSLINE MED/97163706; Hoff CC; Coates TJ; Barrett DC; Collette L; Ekstrand M; Department of Medicine, University of California, San Francisco, USA.; This study describes psychological and behavioral differences between gay men in primary relationships and single men from 1985 through 1989. In addition, differences in sexual behavior, relationship status, and relationship quality between HIV positive and HIV negative men were investigated. Data are from the San Fra
Therapeutic effects of glycyrrhizin in mice infected with LP-BM5 murine retrovirus and mechanisms involved in the prevention of disease progression.: Biotherapy. 1996;9(4):209-20. Unique Identifier : AIDSLINE MED/97164758; Watanbe H; Miyaji C; Makino M; Abo T; Department of Immunology, Niigata University School of Medicine,; Japan.; Glycyrrhizin (GL), a plant extract, has been evaluated for its inhibitory effect on HIV replication in vitro and for its improvement of clinical symptoms in HIV-infected patients. In this study, we used GL in a murine AIDS model (MAIDS) to evaluate these effects. C57BL/6 mice were inoculated with LP-BM5 murine leukemi
Human immunodeficiency virus risk behavior among white and Asian/Pacific Islander high school students in the United States: does culture make a difference?: J Adolesc Health. 1997 Jan;20(1):68-74. Unique Identifier : AIDSLINE MED/97160146; Hou SI; Basen-Engquist K; School of Public Health, University of Texas, Health Science Center at; Houston, USA.; PURPOSE: This article analyzes sexual behavior among white and Asian/Pacific Islander (API) adolescents, to determine the risk for human immunodeficiency virus (HIV) transmission from a multicultural point of view. METHODS: A total of 5,385 white and 408 API high school students were included. The national school-base
The proto-oncogene c-myb is expressed in sporadic bovine lymphoma, but not in enzootic bovine leukosis.: J Vet Med Sci. 1996 Dec;58(12):1169-74. Unique Identifier : AIDSLINE MED/97149904; Asahina M; Ishiguro N; Wu D; Goryo M; Davis WC; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Japan.; We examined bovine c-myb gene expression in six samples of sporadic bovine lymphomas (two calf, three thymic and one intermediate) and five of enzootic bovine leukosis. Tumor cells of the sporadic bovine lymphomas were of immature cell lineage one B lymphoma and five T lymphomas). The c-myb mRNA was expressed in almos
Ordered aggregation of ribonucleic acids by the human immunodeficiency virus type 1 nucleocapsid protein.: Biopolymers. 1997 Mar;41(3):301-12. Unique Identifier : AIDSLINE MED/97210422; Stoylov SP; Vuilleumier C; Stoylova E; De Rocquigny H; Roques BP; Gerard D; Mely Y; Laboratoire de Biophysique, URA 491 du CNRS, Faculte de Pharmacie de; Strasbourg I, Illkirch, France.; The nucleocapsid protein NCp7, which is the major genomic RNA binding protein of human immunodeficiency virus type 1, plays an important role in several key steps of the viral life cycle. Many of the NCp7 activities, notably the nucleic acid annealing and the genomic RNA wrapping ones, are thought to be linked to a no
Characterization of anti-tumor immunity derived from the inoculation of myeloma cells secreting the fusion protein RM4/IFN-tau.: Hum Antibodies Hybridomas. 1996;7(1):21-6. Unique Identifier : AIDSLINE MED/97041562; Qi Y; Moyana T; Chen Y; Xiang J; Saskatoon Cancer Center, College of Medicine, University of; Saskatchewan, Canada.; Our previous study showed that the injection of mouse myeloma VKCK/RM4-IFN-tau cells secreting the fusion protein RM4/IFN-tau to syngeneic BALB/c mice resulted in tumor regression in 70% of mice after tumor inoculation. In this study, the VKCK/RM4-IFN-tau cell line was used to characterize the protective immunity subs
Curative effect of split low dosage total-body irradiation on murine AIDS induced by Friend virus: the results and the possible mechanism.: In Vivo. 1996 Mar-Apr;10(2):191-9. Unique Identifier : AIDSLINE MED/96348850; Shen RN; Lu L; Kaiser HE; Broxmeyer HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202-5121, USA.; Mice infected with Friend Leukemia Virus (FLV) rapidly develop erythroleukemia and severe immune deficiency which resembles human AIDS. We have reported that mice infected with a lethal dose of FLV can be 100% cured by 150 cGy total body irradiation TBI). This curative effect was associated with restoration of cellula
Naturin: a potent bio-immunomodifier in experimental studies and clinical trials.: In Vivo. 1996 Mar-Apr;10(2):201-9. Unique Identifier : AIDSLINE MED/96348851; Shen RN; Lu L; Jia XQ; Wong ML; Kaiser HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 16202-5121, USA.; A number of traditional Chinese medicinal herbs have become extremely interesting in the search for potential BRMs in the international medical community, especially in the United States and Japan . Naturin, a new Chinese medical herb produced by Xing
Meningocerebral lesions in children with iatrogenic AIDS.: Rom J Morphol Embryol. 1996 Jan-Jun;42(1-2):53-62. Unique Identifier : AIDSLINE MED/97190403; Bogdan FL; Radu I; Mogoanta L; Frasie M; Department of Histology, Faculty of Medicine, Craiova, Romania.; This study is focused on structural modifications of leptomeninges and cerebral matter in children deceased because of iatrogenic AIDS. Although we do not evidence the specific lesions of AIDS, we have noticed edema, hyperemia, hematic extravasation, microlesions of the small vessel walls, perivascular infiltrations w
Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta.: Blood. 1997 Mar 1;89(5):1491-500. Unique Identifier : AIDSLINE MED/97210555; Cai J; Zheng T; Lotz M; Zhang Y; Masood R; Gill P; Department of Internal Medicine, University of Southern California; School of Medicine, Los Angeles, USA.; Glucocorticoid (GC) use is known to induce or enhance the growth of Kaposi s sarcoma (KS) in many clinical settings including human immunodeficiency virus infection, collagen vascular disease, lymphoproliferative disorders, and renal transplantation. Because GCs may induce immune suppression and thus tumor growth, we
Absence of human T-lymphotropic virus type I in Japanese patients with cutaneous T-cell lymphoma.: Blood. 1997 Mar 1;89(5):1529-32. Unique Identifier : AIDSLINE MED/97210560; Kikuchi A; Nishikawa T; Ikeda Y; Yamaguchi K; Department of Dermatology, Keio University School of Medicine, Tokyo,; Japan.; Cutaneous T-cell lymphoma (CTCL) is a disease entity characterized by a primary sporadic T-cell proliferation in the skin. Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma. Recently, several authors have detected the HTLV-1 genome in genomic DNA from patients with C
Loss of inducible virus in CD45RA naive cells after human immunodeficiency virus-1 entry accounts for preferential viral replication in CD45RO memory cells.: Blood. 1997 Mar 1;89(5):1635-41. Unique Identifier : AIDSLINE MED/97210573; Woods TC; Roberts BD; Butera ST; Folks TM; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; Controversy exists concerning the preferential infection and replication of human immunodeficiency virus-1 (HIV-1) within naive (CD45RA+) and memory (CD45RO+) subsets of CD4+ lymphocytes. To explore the susceptibility of these subsets to HIV-1 infection, we purified CD45RA+/CD4+ (RA) and CD45RO+/CD4+ (RO) cells from n
Upregulation of c-Fos in activated T lymphoid and monocytic cells by human immunodeficiency virus-1 Tat protein.: Blood. 1997 Mar 1;89(5):1654-64. Unique Identifier : AIDSLINE MED/97210575; Gibellini D; Caputo A; Capitani S; La Placa M; Zauli G; Institute of Microbiology, University of Bologna, Italy.; The regulatory Tat protein of the human immunodeficiency virus type-1 (HIV-1) is essential for viral replication and also shows pleiotropic activities on various cell functions. To get further insights into the molecular mechanisms underlying the biological activity of Tat, we investigated the effect of endogenous and
Is Kaposi's sarcoma--associated herpesvirus ubiquitous in urogenital and prostate tissues?: Blood. 1997 Mar 1;89(5):1686-9. Unique Identifier : AIDSLINE MED/97210578; Tasaka T; Said JW; Morosetti R; Park D; Verbeek W; Nagai M; Takahara J; Koeffler HP; Department of Medicine and Pathology, Cedars-Sinai Medical Center,; UCLA School of Medicine, USA.; Controversy exists as to whether Kaposi s sarcoma-associated herpesvirus (KSHV) is more widespread than originally reported. Recently, Monini et al reported that KSHV is ubiquitous in urogenital and prostate tissues and sperm of healthy Italian adults using nested polymerase chain reaction (PCR). We have examined for
Epstein-Barr virus strains with latent membrane protein-1 deletions: prevalence in the Italian population and high association with human immunodeficiency virus-related Hodgkin's disease.: Blood. 1997 Mar 1;89(5):1723-31. Unique Identifier : AIDSLINE MED/97210583; Dolcetti R; Zancai P; De Re V; Gloghini A; Bigoni B; Pivetta B; De Vita S; Carbone A; Boiocchi M; Division of Experimental Oncology 1, Centro di Riferimento Oncologico,; Aviano, Italy.; Six Epstein-Barr virus (EBV)-related lymphoproliferative disorders were investigated to verify whether the EBV strain harbored by neoplastic cells had the same EBNA-2 and latent membrane protein-1 (LMP-1) DNA sequences of the virus carried by normal lymphocytes of the same patients. Within each case, the analysis of n
Lack of evidence of HHV-8 DNA in blood cells from heart transplant recipients [letter]: Blood. 1997 Mar 1;89(5):1837-8. Unique Identifier : AIDSLINE MED/97210600; De Milito A; Venturi G; Catucci M; Romano L; Bianchi Bandinelli ML; Zazzi M
Efficient in vivo marking of primary CD4+ T lymphocytes in nonhuman primates using a gibbon ape leukemia virus-derived retroviral vector.: Blood. 1997 Mar 15;89(6):1987-95. Unique Identifier : AIDSLINE MED/97211753; Bunnell BA; Metzger M; Byrne E; Morgan RA; Donahue RE; Clinical Gene Therapy Branch, National Center for Human Genome; Research, Bethesda, MD 20850, USA.; High efficiency retroviral-mediated gene transfer to rhesus CD4+ peripheral blood lymphocytes (PBL) was accomplished using an optimized transduction protocol using a gibbon ape leukemia virus GaLV) envelope-containing packaging cell line PG13. Engineered CD4+ PBL were administered to three nonmyeloablated animals in t
Differences between graft-versus-leukemia and graft-versus-host reactivity. I. Interaction of donor immune T cells with tumor and/or host cells.: Blood. 1997 Mar 15;89(6):2189-202. Unique Identifier : AIDSLINE MED/97211777; Rocha M; Umansky V; Lee KH; Hacker HJ; Benner A; Schirrmacher V; Deutsches Krebsforschungszentrum Heidelberg, Abteilung Zellulare; Immunologie, FSP Tumorimmunologie, Germany.; Graft-versus-leukemia (GVL) and Graft-versus-host (GVH) reactions were compared after systemic transfer of allogeneic antitumor immune T lymphocytes from B10.D2 (H-2d; Mls(b)) into DBA/2 (H-2d; Mis(a)) mice. Before immune cell transfer, recipient DBA/2 mice were sublethally irradiated with 5 Gy to prevent host-versus-
Intragraft IL-4 mRNA expression is associated with down-regulation of liver graft rejection.: Clin Transplant. 1996 Dec;10(6 Pt 1):542-9. Unique Identifier : AIDSLINE MED/97150003; Baan CC; Metselaar HJ; Mol WM; Tilanus HW; IJermans JM; Zondervan PE; Schalm SW; Niesters HG; Weimar W; Department of Internal Medicine, University Hospital; Rotterdam-Dijkzigt, The Netherlands.; The mechanism underlying spontaneously resolving allograft rejection following clinical liver transplantation is unidentified. In this process, immunoregulatory T helper (Th)-2 cytokines like IL-4, often identified with down-regulation of the Th1-dependent ( IL-2 ) cell-
Clinical presentation of pulmonary tuberculosis associated with acquired immunodeficiency syndrome in metropolitan Tokyo.: Intern Med. 1996 Dec;35(12):946-52. Unique Identifier : AIDSLINE MED/97182853; Kanazawa M; Fujita A; Toyoda T; Takasugi T; Osumi M; Nishio K; Suzuki A; Ogata H; Iwai K; Department of Medicine, School of Medicine, Keio University, Tokyo.; The clinical features of pulmonary tuberculosis associated with acquired immunodeficiency syndrome (AIDS) in Japan were surveyed utilizing questionnaires completed by 48 institutes around the Tokyo metropolitan area. We found 11 Japanese and six foreign patients. The average number
Using the Kalman filter and dynamic models to assess the changing HIV/AIDS epidemic.: Math Biosci. 1997 Mar;140(2):131-54. Unique Identifier : AIDSLINE MED/97198756; Cazelles B; Chau NP; Centre de Bioinformatique, Universite Paris, France.; Many factors, including therapy and behavioral changes, have modified the course of the HIV/AIDS epidemic in recent years. To include these modifications in HIV/AIDS models, in the absence of appropriate external data sources, changes over time in the parameters can be incorporated by a recursive estimation technique
[Experiences of the "sexually transmitted disease counseling service" of the Recklinghausen district public health office]: Gesundheitswesen. 1996 Dec;58(12):699-702. Unique Identifier : AIDSLINE MED/97177843; Ruter O; Arztin des Gesundheitsamtes, Kreisgesundheitsamt Recklinghausen, Marl.
The effect of adding a surfeit of autologous CD8+ T cells to SCID mice after secondary rexenografts of Graves' thyroid tissue.: Thyroid. 1996 Oct;6(5):429-36. Unique Identifier : AIDSLINE MED/97090780; Mukuta T; Nishikawa M; Arreaza G; Resetkova E; Yoshikawa N; Fornasier V; Young E; Volpe R; Endocrinology Research Laboratory, Wellesley Hospital, University of; Toronto, Ontario, Canada.; To investigate the effect of adding a surfeit of CD8+ T cells as a potential immunoregulator in Graves disease (GD), thyroid tissues from 4 patients with GD and 2 normal subjects (N) were initially xenografted into nude mice. Eight weeks after xenografting, the thyroid tissues, which were then devoid of lymphocytes a
The murine (H-2k) T-cell epitopes of bee venom phospholipase A2 Lie outside the active site of the enzyme. Implications with respect to a paracrine activation of Th2 cells for an IgE antibody response.: Int Arch Allergy Immunol. 1997 Mar;112(3):226-30. Unique Identifier : AIDSLINE MED/97219207; Specht C; Kolsch E; Institute for Immunology, University of Munster, Germany.; Recombinant, enzymatic active phospholipase A2 from bee venom PLA2) is a potent inducer of IgE antibody formation in CBA/J H-2k) mice. In contrast, a recombinant mutant protein lacking enzymatic activity due to an amino acid exchange in the active site of the enzyme fails to induce IgE antibodies under identical immun
Survival after diagnosis of AIDS: a prospective observational study of 2625 patients. Royal Free/Chelsea and Westminster Hospitals Collaborative Group.: BMJ. 1997 Feb 8;314(7078):409-13. Unique Identifier : AIDSLINE MED/97192794; Mocroft A; Youle M; Morcinek J; Sabin CA; Gazzard B; Johnson MA; Phillips AN; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London.; OBJECTIVE: To estimate median survival and changes in survival in patients diagnosed as having AIDS. DESIGN: Prospective observational study. SETTING: Clinics in two large London hospitals. SUBJECTS: 2625 patients with AIDS seen between 1982 and July 1995. MAIN OUTCOME MEASURES: Survival, estimated using lifetable ana
Recent advances. HIV infection--I.: BMJ. 1997 Feb 15;314(7079):487-91. Unique Identifier : AIDSLINE MED/97209626; Cohn JA; School of Medicine, Wayne State University, Detroit, MI 48201-2907,; USA. JCohn@oncgate.roc.wayne.edu
Recent advances. HIV infection-II.: BMJ. 1997 Feb 22;314(7080):579-83. Unique Identifier : AIDSLINE MED/97208778; Beiser C; Institute of Human Virology, University of Maryland Medical System,; Baltimore, USA.
Those who believe in alternative theories of AIDS have little room for manoeuvre [letter]: BMJ. 1997 Feb 22;314(7080):607-8. Unique Identifier : AIDSLINE MED/97208806; Derbyshire SW
High-performance chromatographic assay for the sulphoxide metabolite of 2'-deoxy-3'-thiacytidine in human urine.: J Chromatogr B Biomed Appl. 1996 Dec 13;687(2):457-61. Unique Identifier : AIDSLINE MED/97169929; Plumb RS; Gray RD; Harker AJ; Taylor S; Bioanalysis and Drug Metabolism Department, GlaxoWellcome Research and; Develpment, Greenford, Middleses, UK.; A high-performance liquid chromatographic method is described for the determination in human urine of GI138870X, the sulphoxide metabolite of a novel dideoxynucleoside analogue, 2 -deoxy-3 -thiacytidine (lamivudine). GI138870X was extracted from human urine using Empore SDB RPS solid-phase extraction disks prior to re
The role of cholecystectomy in acquired immunodeficiency syndrome [see comments]: J Am Coll Surg. 1997 Mar;184(3):233-9. Unique Identifier : AIDSLINE MED/97214537; Flum DR; Steinberg SD; Sarkis AY; Pacholka JR; Wallack MK; Department of Surgery, St. Vincent's Hospital and Medical Center, New; York, NY, USA.; BACKGROUND: Hepatobiliary disease is a common manifestation of acquired immunodeficiency syndrome, although the role of surgical intervention in the spectrum of therapy is unclear. STUDY DESIGN: A retrospective review was designed to evaluate the characteristics of patients given a diagnosis of human immunodeficiency
The role of cholecystectomy in acquired immunodeficiency syndrome [editorial; comment] [see comments]: J Am Coll Surg. 1997 Mar;184(3):309-10. Unique Identifier : AIDSLINE MED/97214550; Soper NJ
Indirect muscarinic receptor activation by pentamidine on airway smooth muscle.: Br J Pharmacol. 1996 Nov;119(6):1131-6. Unique Identifier : AIDSLINE MED/97092050; Biyah K; Molimard M; Naline E; Bazelly B; Advenier C; Laboratoire de Pharmacologie, Faculte de Medecine Paris Ouest, France.; 1. Pentamidine is routinely used to reduce the incidence of Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus, but it has been described as inducing pulmonary adverse effects, such as cough and bronchospasm. 2. In this paper we have investigated the effects of pentamidine on guinea-
An atypical case of parasuicide or 'bradysuicide' [letter]: Br J Psychiatry. 1996 Dec;169(6):795-6. Unique Identifier : AIDSLINE MED/97123401; Maniam T
Kaposi's sarcoma and HHV-8 [letter]: Trends Microbiol. 1996 Nov;4(11):419. Unique Identifier : AIDSLINE MED/97108163; Offermann MK
Destroying retroviruses from within.: Trends Microbiol. 1996 Nov;4(11):421-6. Unique Identifier : AIDSLINE MED/97108164; Boeke JD; Hahn B; Dept of Molecular Biology & Genetics, Johns Hopkins University School; of Medicine, Baltimore, MD 21205, USA. jef.boeke@qmail.bs.jhu.edu; One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be
A community P.A.R. Approach to HIV/AIDS prevention among sex workers.: Promot Educ. 1996 Dec;3(4):25-8. Unique Identifier : AIDSLINE MED/97206379; Tiglao TV; Morisky DE; Tempongko SB; Baltazar JC; Detels R; University of the Philippines, College of Public Health, Department of; Health Promotion and Education, Manila, Philippines.
Gut Coccidia-- Isospora, Cryptosporidium, Cyclospora and Sarcocystis.: Semin Gastrointest Dis. 1997 Jan;8(1):33-44. Unique Identifier : AIDSLINE MED/97153210; Ackers JP; Department of Medical Parasitology, London School of Hygiene &; Tropical Medicine, UK.; The gut Coccidia are members of a large, varied, and exclusively intracellular group of protozoan parasites, four species of which Isospora, Cryptosporidium, Cyclospora, and Sarcocystis) are human pathogens. The first three, but particularly Cryptosporidium parvum, have moved from medical curiosities to major problems
Intestinal microsporidiosis.: Semin Gastrointest Dis. 1997 Jan;8(1):45-55. Unique Identifier : AIDSLINE MED/97153211; Croft SL; Williams J; McGowan I; Department of Medical Parasitology, London School of Hygiene and; Tropical Medicine, UK.; Intestinal microsporidiosis is caused by the protozoan parasites Enterocytozoon bieneusi and Encephalitozoon intestinalis. The disease has been described within the past decade and is found predominantly in acquired immunodeficiency syndrome (AIDS) patients in associat
Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques.: Curr Biol. 1996 Nov 1;6(11):1519-27. Unique Identifier : AIDSLINE MED/97147820; Sawai ET; Khan IH; Montbriand PM; Peterlin BM; Cheng-Mayer C; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616, USA. etsawai@ucdavis.edu; BACKGROUND: The primate lentiviruses, human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), encode a conserved accessory gene product, Nef. In vivo, Nef is important for the maintenance of high virus loads and progression to AIDS in SIV-infected adult rhesus macaques. In
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons.: Curr Biol. 1997 Feb 1;7(2):112-21. Unique Identifier : AIDSLINE MED/97227891; Hesselgesser J; Halks-Miller M; DelVecchio V; Peiper SC; Hoxie J; Kolson DL; Taub D; Horuk R; Department of Immunology, Berlex Biosciences, Richmond, California; 94804, USA. Joe_Hesselgesser@berlex.com; BACKGROUND: Chemokines are a family of proteins that chemoattract and activate immune cells by interacting with specific receptors on the surface of their targets. We have shown previously that chemokine receptors including the interleukin-8 receptor B CXCR2) and the Duffy blood group antigen are expressed on subsets
Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion.: Gene Ther. 1996 Jan;3(1):4-12. Unique Identifier : AIDSLINE MED/97083332; DeMatteo RP; Markmann JF; Kozarsky KF; Barker CF; Raper SE; Institute for Human Gene Therapy, University of Pennsylvania Medical; Center, Philadelphia, USA.; Although first generation recombinant adenoviruses are efficient vehicles for gene transfer, their immunogenicity precludes long-term persistence. We show that adenoviral transgene expression in the liver of normal mice is prolonged from a baseline of less than 2 weeks to 7 weeks by depleting CD4+ T lymphocytes with t
High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS.: Gene Ther. 1997 Feb;4(2):128-39. Unique Identifier : AIDSLINE MED/97226862; Plavec I; Agarwal M; Ho KE; Pineda M; Auten J; Baker J; Matsuzaki H; Escaich S; Bonyhadi M; Bohnlein E; Progenesys Program, SyStemix Inc, Palo Alto, CA 94304, USA.; Expression of antiviral genes in CD4+ T cells has been proposed as a strategy for gene therapy of AIDS. Over the past years, we and others have developed retroviral vectors encoding the RevM10 protein, a dominant-negative mutant of the HIV-1 Rev trans-activator protein. We could demonstrate gene transfer and inhibitio
Induction of somatic mutation in a human B cell line in vitro.: Immunity. 1997 Jan;6(1):35-46. Unique Identifier : AIDSLINE MED/97205331; Denepoux S; Razanajaona D; Blanchard D; Meffre G; Capra JD; Banchereau J; Lebecque S; Schering-Plough Laboratory for Immunological Research, Dardilly,; France.; Both the B cell-surface trigger(s) and the intracellular molecular mechanism(s) of somatic hypermutation in immunoglobulin Ig) variable region genes remain unknown, partly because of the lack of a simple and reproducible in vitro model. Here, we show that upon surface immunoglobulin cross-linking followed by co-cultur
The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.: Immunity. 1997 Jan;6(1):67-77. Unique Identifier : AIDSLINE MED/97205334; Mangasarian A; Foti M; Aiken C; Chin D; Carpentier JL; Trono D; Infectious Disease Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; The HIV Nef protein down-regulates the cell surface expression of CD4 and of MHC I at least in part through accelerated endocytosis. To investigate further the mechanism of this effect, we created chimeric integral membrane proteins comprising the extracellular and transmembrane regions of CD4 or CD8 and Nef as the cy
Neonatal injection of an ovarian peptide induces autoimmune ovarian disease in female mice: requirement of endogenous neonatal ovaries.: Immunity. 1997 Jan;6(1):89-96. Unique Identifier : AIDSLINE MED/97205336; Garza KM; Griggs ND; Tung KS; Department of Microbiology, University of Virginia, Charlottesville; 22908, USA.; Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is esta
[Proliferative mechanism and control of AIDS virus]: Nihon Rinsho Meneki Gakkai Kaishi. 1996 Dec;19(6):548-51. Unique Identifier : AIDSLINE MED/97194327; Okamoto H
[Physiopathology and gene therapy of HIV infection]: Nihon Rinsho Meneki Gakkai Kaishi. 1996 Dec;19(6):651-3. Unique Identifier : AIDSLINE MED/97194347; Matsushita S
Central areolar choroidal dystrophy and slowly progressive sensorineural hearing loss.: Acta Ophthalmol Scand. 1996 Dec;74(6):639-41. Unique Identifier : AIDSLINE MED/97169500; Hoyng CB; van Rijn PM; Deutman AF; Department of Ophthalmology, University of Nijmegen, The Netherlands.; Central areolar choroidal dystrophy (CACD) is a rare hereditary disorder leading to a central scotoma in middle-aged patients. Two cases of CACD in association with perceptive hearing loss are discussed. A 62-year-old male and a 51-year-old female patient complained of visual deterioration and subsequent hearing loss
Protamine enhances the activity of human recombinant interferon-gamma.: J Interferon Cytokine Res. 1996 Jul;16(7):531-6. Unique Identifier : AIDSLINE MED/96433940; Daubener W; Gutsche M; Nockemann S; MacKenzie C; Seghrouchni S; Hadding U; Institut fur Medizinische Mikrobiologie und Virologie,; Heinrich-Heine-Universitat Dusseldorf, Germany.; Recombinant interferon-gamma (IFN-gamma) is a potent immune regulatory cytokine and is involved in the defense against several intracellular organisms, such as Chlamydia and Toxoplasma. Furthermore IFN-gamma is able to inhibit the growth of human tumor cell lines. The ability to inhibit the growth of intracellular org
Aetiological factors for oral manifestations of HIV.: Oral Dis. 1996 Sep;2(3):193-7. Unique Identifier : AIDSLINE MED/97227796; Palmer GD; Robinson PG; Challacombe SJ; Birnbaum W; Croser D; Erridge PL; Hodgson T; Lewis D; McLaren A; Zakrzewska JM; United Medical School, Guy's Hospital, London, UK.; OBJECTIVES: Describe the oral diseases in HIV-infected individuals in London, UK and identify social and medical factors related to the presence of specific oral diseases. DESIGN: Dental clinics. SUBJECTS: Consecutive sample of 456 patients with HIV infection. METHODS: Social and medical history and clinical examinati
Oral HIV-I recovery in the presence of periodontal disease.: Oral Dis. 1996 Sep;2(3):198-201. Unique Identifier : AIDSLINE MED/97227797; Barr CE; Qureshi MN; Qiu Z; Kaim J; Zhang W; Department of Dental Medicine, Beth Israel Medical Center, New York; 10003, USA.; OBJECTIVE: To determine whether a significant association occurs between the presence of various periodontal diseases and recoverable infectious HIV-I in the saliva of injecting drug users. DESIGN: Five hundred and fifty-one injecting drug users were recruited from various programs associated with the Beth Israel Medi
HIV-1 infection in an individual homozygous for the CCR5 deletion allele [letter; comment]: Nat Med. 1997 Mar;3(3):252-3. Unique Identifier : AIDSLINE MED/97208900; Biti R; Ffrench R; Young J; Bennetts B; Stewart G; Liang T
HIV-1: gambling on the evolution of drug resistance?: Nat Med. 1997 Mar;3(3):268-71. Unique Identifier : AIDSLINE MED/97208904; Brown AJ; Richman DD; Centre for HIV Research, University of Edinburgh, Scotland.
Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.: Nat Med. 1997 Mar;3(3):287-92. Unique Identifier : AIDSLINE MED/97208913; Nicholas J; Ruvolo VR; Burns WH; Sandford G; Wan X; Ciufo D; Hendrickson SB; Guo HG; Hayward GS; Reitz MS; Department of Oncology, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; Human herpesvirus-8 (HHV-8) has been detected in Kaposi s sarcoma KS) lesions of all types (AIDS-related, classical and endemic), in body-cavity-based B-cell lymphomas (BCBLs) and in lesions of multicentric Castleman s disease (MCD). We have identified a major gamma-herpesvirus-divergent locus (DL-B) in HHV-8 DNA enco
Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue.: Nat Med. 1997 Mar;3(3):293-8. Unique Identifier : AIDSLINE MED/97208914; Sarid R; Sato T; Bohenzky RA; Russo JJ; Chang Y; Department of Pathology, Columbia University College of Physicians &; Surgeons, New York, New York 10032, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) is a newly discovered herpesvirus etiologically associated with Kaposi s sarcoma (KS) and two lymphoproliferative disorders. We describe a KSHV vbcl-2 gene with homology to the proto-oncogene bcl-2. It is expressed in KS lesions and in cell lines derived from primary effu
The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication.: Nat Med. 1997 Mar;3(3):333-7. Unique Identifier : AIDSLINE MED/97208921; Chinnaiyan AM; Woffendin C; Dixit VM; Nabel GJ; Department of Pathology, University of Michigan Medical Center, Ann; Arbor, Michigan 48109-0602, USA.; Accelerated programmed cell death, or apoptosis, contributes to the CD4+ T-cell depletion characteristic of infection by human immunodeficiency virus (HIV). It has therefore been proposed that limiting apoptosis may represent a therapeutic modality for HIV infection. We found, however, that T leukemia cells or periphe
The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression.: Nat Med. 1997 Mar;3(3):338-40. Unique Identifier : AIDSLINE MED/97208922; Michael NL; Chang G; Louie LG; Mascola JR; Dondero D; Birx DL; Sheppard HW; Division of Retrovirology, Walter Reed Army Institute of Research,; Rockville, Maryland, USA.; Cellular entry of human immunodeficiency virus type 1 (HIV-1) requires binding to both CD4 (ref, 1, 2) and to one of the chemokine receptors recently discovered to act as coreceptors. Viruses that infect T-cell lines to form syncytia syncytium-inducing, SI) are frequently found in late-stage HIV disease and utilize th
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.: Nat Med. 1997 Mar;3(3):341-5. Unique Identifier : AIDSLINE MED/97208923; Rice WG; Turpin JA; Huang M; Clanton D; Buckheit RW Jr; Covell DG; Wallqvist A; McDonnell NB; DeGuzman RN; Summers MF; Zalkow L; Bader JP; Haugwitz RD; Sausville EA; Laboratory of Antiviral Drug Mechanisms, National Cancer; Institute-Frederick Cancer Research and Development Center, SAIC; Frederick, Maryland 21702, USA.; Nucleocapsid p7 (NCp7) proteins of human immunodeficiency virus type 1 (HIV-1) contain two zinc binding domains of the sequence Cys-(X)2-Cys-(X)4-His-(X)4-Cys (CCHC). The spacing pattern and metal-chelating residues (3 Cys, 1 His) of these nucleocapside CCHC zinc fingers are highly conserved among retroviruses. These
Secondary immunodeficiencies and stem cell transplantation: issues of administration and safety of intravenous immunoglobulin.: Clin Ther. 1996;18 Suppl B:126-36. Unique Identifier : AIDSLINE MED/97084106; Sullivan KM; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; This article reviews the administration, efficacy, and safety of prophylactic intravenous immunoglobulin in patients with secondary immunodeficiency and those undergoing allogeneic bone marrow transplantation. Associated infections in these immunosuppressed patients are examined as they relate to transfusion-associate
Hepatitis C virus infection in Italian patients with hypogammaglobulinemia.: Clin Ther. 1996;18 Suppl B:96-107. Unique Identifier : AIDSLINE MED/97084103; Quinti I; Pandolfi F; Paganelli R; Giovannetti A; Sacco G; Oliva A; Aiuti F; Department of Allergy and Clinical Immunology, University La Sapienza,; Rome, Italy.; We investigated the presence of hepatitis C virus (HCV) infection in 58 patients with humoral immunodeficiencies. Forty-three of these patients had common variable immunodeficiency (CVI), 2 had sporadic hyperimmunoglobulin M (HIM) syndrome, 2 had immunoglobulin G subclass deficiency, 4 had ataxia-telangiectasia AT), a
Experts attempt to redefine principles for treating HIV [news]: Nat Biotechnol. 1997 Jan;15(1):14-5. Unique Identifier : AIDSLINE MED/97187643; Fox JL
A new class of antigen-specific killer cells [see comments]: Nat Biotechnol. 1997 Jan;15(1):46-51. Unique Identifier : AIDSLINE MED/97187652; Yang AG; Chen SY; Department of Cancer Biology, Bowman Gray School of Medicine, Wake; Forest University, Winston-Salem, NC 27157, USA.; A new class of antigen-specific killer cells that combines the features of antibody-mediated and cell-mediated immunity was designed. The principle and feasibility of this strategy are illustrated by creating an antigen-specific killer cell to produce and secrete targeted antibody-toxin molecules that recognize and ki
The MHC reactivity of the T cell repertoire prior to positive and negative selection.: Cell. 1997 Mar 7;88(5):627-36. Unique Identifier : AIDSLINE MED/97207009; Zerrahn J; Held W; Raulet DH; Department of Molecular and Cell Biology, Cancer Research Laboratory,; University of California, Berkeley 94720, USA.; T cell antigen receptors (TCRs) on mature T cells react with peptide antigens presented by self-MHC proteins and also frequently cross-react with foreign MHC proteins. The fundamental question whether MHC reactivity is inherent in the germline TCR sequences or is imposed by thymic selection was addressed here by induc
Costimulatory effect of IL-12 on the activation of naive, memory CD4+ T cells, and Th1 clone.: Cell Immunol. 1997 Feb 25;176(1):50-8. Unique Identifier : AIDSLINE MED/97223496; Kato T; Morokata T; Igarashi O; Yee ST; Inobe M; Uede T; Azuma M; Okumura K; Nariuchi H; Department of Allergology, Institute of Medical Science, University of; Tokyo, Japan.; In the present experiments, costimulatory effects of interleukin 12 (IL-12) and B7-2 on interleukin 2 receptor alpha chain (IL-2R alpha) expression and IL-2-dependent proliferation of naive and memory CD4+ T cells were studied in comparison with the effect of these molecules on Th1 clones. The naive and memory T cells
What is new in clinical research of viral diseases of the skin.: Dermatol Clin. 1997 Jan;15(1):189-96. Unique Identifier : AIDSLINE MED/97155157; Walther RR; Department of Dermatology, College of Physicians and Surgeons,; Columbia University, New York, New York, USA.; Viral diseases of the skin have become a much more serious problem with the increasing number of patients immunosuppressed by either AIDS or cancer chemotherapy. The emphasis in research on the diagnosis and treatment of these diseases is similar to that on the bacterial diseases several decades ago.
Gender differences in characteristics, infection control practices, knowledge and attitudes related to HIV among Ontario dentists.: Community Dent Oral Epidemiol. 1996 Dec;24(6):412-5. Unique Identifier : AIDSLINE MED/97159844; McCarthy GM; MacDonald JK; Faculty of Dentistry, University of Western Ontario, London, Canada.; We surveyed 5,997 dentists in Ontario to investigate gender differences in the characteristics, infection control practices, knowledge and attitudes regarding the treatment of HIV-infected patients. The response rate was 70.3%. Reports indicated that female dentists are younger and more likely to work in larger urban
Alcoholism, a contagious disease. A contribution towards an anthropological definition of contagion.: Cult Med Psychiatry. 1996 Dec;20(4):473-87. Unique Identifier : AIDSLINE MED/97144153; Fainzang S; National Institute of Health and Medical Research, INSERM, Paris.; The goal of this article is to show, from the discourses of drinkers spouses, members of a cured-drinkers movement in France very different from the AA, what the idea of the contagious character of alcoholism means in the subjects representations and by extension, what the idea
Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence.: Drug Metab Dispos. 1996 Dec;24(12):1298-306. Unique Identifier : AIDSLINE MED/97126210; Lin JH; Chiba M; Chen IW; Nishime JA; Vastag KJ; Drug Metabolism I, Merck Reserch Laboratories, West Point, PA 19486,; USA.; Indinavir , a potent and specific inhibitor of human immunodeficiency virus protease, is used for the treatment of AIDS. This study was designed to investigate the sex-related differences in kinetics and metabolism of indinavir in rats, dogs, and monke
Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans.: Drug Metab Dispos. 1996 Dec;24(12):1389-94. Unique Identifier : AIDSLINE MED/97126223; Balani SK; Woolf EJ; Hoagland VL; Sturgill MG; Deutsch PJ; Yeh KC; Lin JH; Department of Drug Metabolism, Merck Research Laboratories, West; Point, PA 19486, USA.; Indinavir , N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-tertiary- butylaminocarbonyl-4-(3-pyridylmethyl)piperazino]-4(S)- hydroxy-2(R)-phenylmethylpentanamide (L-735,524,MK-639, ayl-4- Crixivan
Characterization of intermediates in the oxidation of zinc fingers in human immunodeficiency virus type 1 nucleocapsid protein P7.: Drug Metab Dispos. 1996 Dec;24(12):1395-400. Unique Identifier : AIDSLINE MED/97126224; Hathout Y; Fabris D; Han MS; Sowder RC 2nd; Henderson LE; Fenselau C; Structural Biochemistry Center, University of Maryland Baltimore; County, 21250, USA.; Oxidants targeted toward inactivation of the nucleocapsid zinc finger protein are under development as antiviral agents, especially for use against human immunodeficiency virus. In the present study, electrospray ionization-mass spectrometry is used to follow in situ the progress of the reactions of 2,2 -dithiodipyrid
Psychopathology and HIV risk behaviors among injection drug users in and out of treatment.: Drug Alcohol Depend. 1996 Dec 2;43(1-2):1-11. Unique Identifier : AIDSLINE MED/97116050; Dinwiddie SH; Cottler L; Compton W; Abdallah AB; Washington University School of Medicine, Department of Psychiatry,; St. Louis, MO 63110-1093, USA.; To replicate prior descriptions of injection drug users (IDUs), 158 IDUs recruited via a street-outreach program were compared to 320 non-IDUs on measures of substance use, lifetime psychopathology, and HIV risk behavior. IDUs were more likely to receive a diagnosis of antisocial personality disorder, but not other ps
Lack of a pharmacologic interaction between rifabutin and methadone in HIV-infected former injecting drug users.: Drug Alcohol Depend. 1996 Dec 2;43(1-2):71-7. Unique Identifier : AIDSLINE MED/97116057; Brown LS; Sawyer RC; Li R; Cobb MN; Colborn DC; Narang PK; Addiction Research and Treatment Corporation, Brooklyn, NY 11201, USA.; Rifampin, an agent known to decrease the half-life of methadone, and rifabutin are two rifamycins that are structurally similar and share mechanisms of action. Hence the possibility of a drug-drug interaction between rifabutin and methadone was evaluated in 24 methadone-maintained, former injecting drug users infected
[Does methadone lessen HIV risk behavior?]: Dtsch Med Wochenschr. 1997 Feb 21;122(8):A7-8. Unique Identifier : AIDSLINE MED/97232157; Mader U
Drug treatment of HIV-related opportunistic infections.: Drugs. 1997 Jan;53(1):40-73. Unique Identifier : AIDSLINE MED/97163893; Klepser ME; Klepser TB; Division of Clinical and Administrative Pharmacy, College of Pharmacy,; University of Iowa, Iowa City 52242-1112, USA.; michael_klepser@uiowa.edu; The AIDS epidemic has led to the emergence of several disease entities which in the pre-AIDS era were rare or seemingly innocuous. Experience of treating these diseases varies. In some instances, such as Pneumocystis carinii pneumonia, there is an abundance of published literature to direct our course of action. Howev
Microsporidium-associated sinusitis.: Ear Nose Throat J. 1997 Feb;76(2):95-101. Unique Identifier : AIDSLINE MED/97198654; Moss RB; Beaudet LM; Wenig BM; Nelson AM; Firpo A; Punja U; Scott TS; Kaliner MA; Allergic Disease Section, NIAID, NIH, Bethesda, Maryland, USA.; Two cases of biopsy-proven Microsporidium-associated chronic sinusitis in HIV-seropositive patients are presented. Spores of Septata intestinalis were identified by light microscopy and confirmed by electron microscopy in each case. Both patients displayed severe deficiencies of nasal mucosa CD4-positive cells, demons
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling.: EMBO J. 1997 Feb 17;16(4):673-84. Unique Identifier : AIDSLINE MED/97201511; Iafrate AJ; Bronson S; Skowronski J; Department in Molecular Genetics and Microbiology, SUNY at Stony; Brook, NY 11794, USA.; The Nef protein alters T cell receptor (TCR) signaling in T cells and is critical for the pathogenesis of AIDS. We used a transient expression assay in a human CD4+ T cell line to analyze the interaction of Nef with the TCR machinery. We show that, in addition to down-regulating CD4 expression on the cell surface, Nef
The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budding in MDCK cells.: EMBO J. 1997 Feb 17;16(4):695-705. Unique Identifier : AIDSLINE MED/97201513; Lodge R; Lalonde JP; Lemay G; Cohen EA; Departement de Microbiologie et Immunologie, Universite de; Montreal,Quebec, Canada.; Budding of retroviruses from polarized epithelial Madin-Darby canine kidney cells (MDCK) takes place specifically at the basolateral membrane surface. This sorting event is suspected to require a specific signal harbored by the viral envelope glycoprotein and it was previously shown that, as for most basolateral prote
[AIDS in Mexico and the world: a global view]: Gac Med Mex. 1996;132 Suppl 1:1-138. Unique Identifier : AIDSLINE MED/97171767; Soberon-Acevedo G; Vilar-Puig P; Ramon de la Fuente J; Izazola-Licea JA; Mann JM; Cowal SG; Zacarias F; Liguori AL; Romero-Keith J; Tapia-Conyer R; Sepulveda J; Bronfman M; Rico B; Mohar A; Langer A; Ponce de Leon-Rosales S; Rangel-Frausto MS; Vazguez de-la-Serna A; Huertas M; Martinez-Abaroa C; Munoz-Hernandez O; Zarate-Aguilar A; Garduno-Espinosa J; Zuniga-Avila J; Mendoza-Zepeda R; et al; Fundacion Mexicanaparala Salud, Tepepan, Mexico, D.F.
Influence of hydrogen peroxide on the in vitro infectivity of human immunodeficiency virus.: Free Radic Biol Med. 1996;20(4):573-7. Unique Identifier : AIDSLINE MED/97059977; Ranjbar S; Holmes H; National Institute for Biological Standard and Controls, South Mimms,; Potters Bar, Herts, UK.; The object of this study was to investigate the influence of reactive oxygen intermediates (ROI), such as H2O2, on HIV-1 infection of cell cultures. The CD4+ HeLa human epithelial carcinoma cell line clone pBKTRLac was infected with HIV-1MN that had been treated with 0.01-5mM H2O2. Virus infectivity was detected by 3
[Efficacy of 2 combined drugs for HIV infected patients (news)]: Fortschr Med. 1996 Dec 10;114(34):61. Unique Identifier : AIDSLINE MED/97151932
HIV-2 prevalence in Uttar Pradesh.: Indian J Med Res. 1996 Mar;103:131-3. Unique Identifier : AIDSLINE MED/97215706; Kulshreshtha R; Mathur A; Chattopadhya D; Chaturvedi UC; Postgraduate Department of Microbiology, K.G. Medical College,; Lucknow.; Serum samples collected since 1989 with various patterns of reactivity for human immunodeficiency virus (HIV)-1, on the basis of screening ELISA and confirmatory Western blot (WB) test, were subjected to the detection of HIV-2 infection based on screening dot immunoassay and confirmatory WB for HIV-2. Significant prev
HIV encephalopathy.: Indian Pediatr. 1996 Oct;33(10):863-5. Unique Identifier : AIDSLINE MED/97210310; Shroff RC; Merchant RH; Gilada IS; Department of Pediatric Medicine, B.J. Wadia Hospital for Children,; Parel, Bombay.
Quantitative molecular monitoring of HIV-1 RNA during antiretroviral therapy.: Infection. 1996 Nov-Dec;24(6):412-8. Unique Identifier : AIDSLINE MED/97160071; Lafeuillade A; Poggi C; Pellegrino P; Profizi N; Dept. of Infectious Diseases, Hopital Chalucet, Toulon, France.; Plasma HIV-1 RNA testing was used to monitor 43 HIV-1 infected patients newly placed on antiretroviral therapy or whose therapy had been recently changed. A polymerase chain reaction kit was used to measure HIV-1 RNA in clinical samples or frozen plasma. The cutoff of this test was 200 RNA copies/ml. The first group 1
Zidovudine resistance mutations and human immunodeficiency virus type 1 DNA burden: longitudinal evaluation of six patients under treatment.: Infection. 1996 Nov-Dec;24(6):419-25. Unique Identifier : AIDSLINE MED/97160072; Zazzi M; Catucci M; De Milito A; Romano L; Venturi G; Almi P; Gonnelli A; Rubino M; Valensin PE; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; Zidovudine (ZDV) is by far the most widely used drug to counteract human immunodeficiency virus type 1 (HIV-1) infection, both in monotherapy and in combination therapy regimens. However, the majority of patients under prolonged ZDV therapy have been shown to harbour H
High prevalence of opportunistic infections in the head and neck related to human immunodeficiency virus. A prospective study of the distribution of otorhinolaryngologic disorders in 250 patients.: Infection. 1996 Nov-Dec;24(6):440-6. Unique Identifier : AIDSLINE MED/97160076; Riederer AP; Grein GO; Bogner JR; Klinik und Poliklinik fur Hals-, Nasen- und Ohrenkranke,; Ludwig-Maximilians-Universitat Munchen, Germany.
Women as dental patients: are there any gender differences?: Int Dent J. 1996 Dec;46(6):548-57. Unique Identifier : AIDSLINE MED/97176005; Zakrzewska JM; Department of Oral Medicine, St Bartholomew's, London, UK.; There is an increasing awareness that gender differences affect both health and disease. This review looks at gender differences as they pertain to the mouth. Not only does pregnancy, the menstrual cycle and the menopause affect the oral tissues but there are also gender differences in regard to patterns of dental dis
[Focusing on therapy of systemic mycoses]: Internist (Berl). 1995 Dec;36(12 Suppl):1-12. Unique Identifier : AIDSLINE MED/97174723
[News in the therapy of onychomycoses (Itraconazole)]: Hautarzt. 1995 Nov;46(11 Suppl):1-8. Unique Identifier : AIDSLINE MED/97174718
Detection of HBsAg and HIV carriage among blood donors or rural population of Loni areas.: J Assoc Physicians India. 1995 May;43(5):378. Unique Identifier : AIDSLINE MED/97076564; Jain RC; Soni SB
Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter.: J Biol Chem. 1997 Feb 21;272(8):4953-8. Unique Identifier : AIDSLINE MED/97184143; Dittmer J; Pise-Masison CA; Clemens KE; Choi KS; Brady JN; Virus Tumor Biology Section, Laboratory of Molecular Virology, NCI,; National Institutes of Health, Bethesda, Maryland 20892-5005, USA.; We have previously shown that the parathyroid hormone-related protein (PTHrP) promoter contains binding sites for transcription factors Ets1 and Sp1 and that human T-cell lymphotropic virus type I (HTLV-I) Tax cooperates with Ets1 to transactivate the PTHrP P2 promoter. Using the yeast two-hybrid interaction system, w
Analysis of PCR as a tool for detection of JC virus DNA in cerebrospinal fluid for diagnosis of progressive multifocal leukoencephalopathy.: J Clin Microbiol. 1996 Dec;34(12):2929-32. Unique Identifier : AIDSLINE MED/97095003; Hammarin AL; Bogdanovic G; Svedhem V; Pirskanen R; Morfeldt L; Grandien M; Department of Virology, Swedish Institute for Infectious Disease; Control, Stockholm, Sweden.; Two polyomaviruses, JC virus (JCV) and BK virus (BKV), affect humans. JCV is the causative agent of progressive multifocal leukoencephalopathy (PML), and detection of JCV in the central nervous system (CNS) is a prerequisite for confirmation of the disease. BKV is generally not associated with neurological disease, bu
Evaluation of the Digene Hybrid Capture System for detection and quantitation of human cytomegalovirus viremia in human immunodeficiency virus-infected patients.: J Clin Microbiol. 1996 Dec;34(12):2959-62. Unique Identifier : AIDSLINE MED/97095009; Mazzulli T; Wood S; Chua R; Walmsley S; Department of Microbiology, University of Toronto, Mount Sinai; Hospital, Ontario, Canada.; The Digene Hybrid Capture System (DHCS) is a solution hybridization antibody capture assay for the chemiluminescent detection and quantitation of cytomegalovirus ( CMV ) DNA in leukocytes. This assay was compared with the CMV a
Multicenter comparison of three commercial methods for quantification of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1996 Dec;34(12):3016-22. Unique Identifier : AIDSLINE MED/97095020; Schuurman R; Descamps D; Weverling GJ; Kaye S; Tijnagel J; Williams I; van Leeuwen R; Tedder R; Boucher CA; Brun-Vezinet F; Loveday C; Eijkman Winkler Institute for Medical Microbiology, Department of; Virology, Utrecht University, The Netherlands. r.schuurman@lab.azu.nl; Three procedures for the quantification of human immunodeficiency virus type 1 (HIV-1) RNA from plasma were compared at three laboratories. The comparison involved the Quantiplex branched DNA assay (version 1.0) by Chiron Diagnostics, the NASBA-QT assay by Organon Teknika, and the Amplicor Monitor assay by Roche Molec
Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus.: J Clin Microbiol. 1996 Dec;34(12):3180-4. Unique Identifier : AIDSLINE MED/97095047; Poland AM; Vennema H; Foley JE; Pedersen NC; Center for Companion Animal Health, School of Veterinary Medicine,; University of California, Davis 95616, USA.; Two groups of cats were experimentally infected orally with the cat-passaged RM strain of feline enteric coronavirus (FECV-RM). One group of cats (n = 19) had been chronically infected with feline immunodeficiency virus (FIV) for over 6 years, while a second control group (n = 20) consisted of FIV-naive siblings. Feca
An enhanced-sensitivity branched-DNA assay for quantification of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1996 Dec;34(12):3196-202. Unique Identifier : AIDSLINE MED/97095050; Kern D; Collins M; Fultz T; Detmer J; Hamren S; Peterkin JJ; Sheridan P; Urdea M; White R; Yeghiazarian T; Todd J; Chiron Corporation, Emeryville, California 94608-2916, USA.; The quantification of human immunodeficiency virus type 1 (HIV-1) RNA has facilitated clinical research and expedited the development of antiretroviral drugs. The branched-DNA (bDNA) assay provides a reliable method for the quantification of HIV-1 RNA in human plasma and is considered one of the most reproducible assa
Comparative evaluation of three antifungal susceptibility test methods for Candida albicans isolates and correlation with response to fluconazole therapy.: J Clin Microbiol. 1996 Dec;34(12):3208-11. Unique Identifier : AIDSLINE MED/97095053; Ruhnke M; Schmidt-Westhausen A; Engelmann E; Trautmann M; Abteilung Innere Medizin and Poliklinik, Virchow-Klinikum,; Humboldt-Universitat, Berlin, Germany. mruhnke@.ukrv.de; In vitro susceptibilities were determined for 56 Candida albicans isolates obtained from the oral cavities of 41 patients with human immunodeficiency virus infection. The agents tested included fluconazole, itraconazole, ketoconazole, flucytosine, and amphotericin B. MICs were determined by the broth microdilution tec
Detection of the microsporidian parasite Enterocytozoon bieneusi in specimens from patients with AIDS by PCR.: J Clin Microbiol. 1996 Dec;34(12):3230-2. Unique Identifier : AIDSLINE MED/97095059; Velasquez JN; Carnevale S; Guarnera EA; Labbe JH; Chertcoff A; Cabrera MG; Rodriguez MI; Department of Parasitology, National Institute of Microbiology, Dr.; Carlos G. Malbran, Buenos Aires, Argentina. parasito@malbra.sld.ar; Microsporidia are protozoa parasites responsible for significant gastrointestinal disease in patients infected with human immunodeficiency virus. We evaluated a PCR assay of stool samples, duodenal aspirates, and biopsy specimens from patients with Enterocytozoon bieneusi infection. A 210-bp DNA fragment of the unique
Interest of quantitative pp65 cytomegalovirus antigenemia assay for human immunodeficiency virus-positive patients [letter; comment]: J Clin Microbiol. 1996 Dec;34(12):3255-6. Unique Identifier : AIDSLINE MED/97095070; Ranger-Rogez S; Couty JP; Nicot T; Denis F; Rogez JP; Riche A; Weinbreck P
Changes in the distribution of cells expressing tumour-associated antigen in lymph nodes during the progression of enzootic bovine leukosis.: J Comp Pathol. 1996 Nov;115(4):343-52. Unique Identifier : AIDSLINE MED/97157798; Koguchi A; Chiba T; Hiraga M; Hasuta Y; Tsujimoto T; Furusato K; Goryo M; Davis WC; Aida Y; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Morioka, Japan.; A monoclonal antibody (MAb), c143, that recognizes a tumour-associated antigen that is upregulated on neoplastic B cells in cattle with enzootic bovine leukosis (EBL), was used as a marker to study disease progression. An immunohistochemical examination of neoplastic tissue and superficial cervical lymph nodes from
The anti-HIV-1 activity associated with saliva.: J Dent Res. 1997 Feb;76(2):634-40. Unique Identifier : AIDSLINE MED/97216299; Shine N; Konopka K; Duzgunes N; Department of Microbiology, University of the Pacific, School of; Dentistry, San Francisco, California 94115-2399, USA.; This review summarizes the data on the anti-human immunodeficiency virus (HIV) activity associated with saliva and the possible routes of oral transmission of HIV. Saliva can be passed from an HIV-infected individual to an uninfected person via sexual or non-sexual activities. The relative risk of HIV transmission thr
HIV/AIDS risk in heterosexual college students. A review of a decade of literature.: J Am Coll Health. 1997 Jan;45(4):147-58. Unique Identifier : AIDSLINE MED/97171832; Lewis JE; Malow RM; Ireland SJ; University of Miami/Jackson Memorial Medical Center, Florida, USA.; Empirical studies dealing with the psychosocial correlates of HIV risk among heterosexual college students are reviewed, including findings related to such theoretical variables as HIV/AIDS-related knowledge, personal and partner s attitudes toward condom use, perceived susceptibility, communication with sex partners,
Internalized homophobia in a sample of HIV+ gay men, and its relationship to psychological distress, coping, and illness progression.: J Homosex. 1996;32(2):91-106. Unique Identifier : AIDSLINE MED/97164081; Wagner G; Brondolo E; Rabkin J; New York State Psychiatric Institute (NYSPI), USA.; The purpose of this study was to determine whether internalized homophobia is related to psychological distress and coping style and whether these relationships are moderated by illness stage. A sample of gay men, most of whom were HIV+, Caucasian, and well educated, were administered assessments at both baseline and
Development of IFN-gamma-producing CD8+ gamma delta+ T lymphocytes and IL-2-producing CD4+ alpha beta+ T lymphocytes during contact sensitivity.: J Immunol. 1997 Mar 15;158(6):2567-75. Unique Identifier : AIDSLINE MED/97211821; Dieli F; Asherson GL; Sireci G; Dominici R; Scire E; Salerno A; Institute of General Pathology, University of Palermo, ISMEDA-CNR,; Italy.; This paper describes the development of Ag-specific proliferation and the production of IFN-gamma and IL-2 during contact sensitivity (CS) to the hapten picryl chloride (PCl). Lymph node cells from mice immunized with PCl proliferate and produce IFN-gamma and IL-2 when
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.: J Immunol. 1997 Mar 15;158(6):2648-53. Unique Identifier : AIDSLINE MED/97211830; Nakamura T; Lee RK; Nam SY; Podack ER; Bottomly K; Flavell RA; Section of Immunobiology, Yale University School of Medicine, Howard; Hughes Medical Institute, New Haven, CT 06520, USA.; It has previously been reported that Th1 CD4 T cell populations can be converted to IL-4 producers, whereas Th2 populations are refractory to IL-12-mediated IFN-gamma production. We have recently shown that CD30 is a marker for the IL-4 response and have therefore used CD30 here to study Th1 and Th2 commitment. We sho
Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals.: J Immunol. 1997 Mar 15;158(6):2654-62. Unique Identifier : AIDSLINE MED/97211831; Palmer EM; van Seventer GA; Department of Pathology, University of Chicago, IL 60637, USA.; We have developed an in vitro differentiation model for human Th cells to study the role of cytokines and accessory cell-dependent costimulatory signals in this process. Peripheral blood-derived CD4+ naive (CD45RA+ RO-) T cells were stimulated in weekly intervals with immobilized anti-CD3 mAb, accessory cells, and e
Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86.: J Immunol. 1997 Mar 15;158(6):2713-22. Unique Identifier : AIDSLINE MED/97211838; Schweitzer AN; Borriello F; Wong RC; Abbas AK; Sharpe AH; Department of Pathology, Brigham & Women's Hospital, Harvard Medical; School, Boston, MA 02115, USA.; For T cells to be optimally activated, recognition of Ag/MHC complexes by the TCR must be accompanied by a second, costimulatory signal that can be provided efficiently by the related costimulatory molecules CD80 (B7-1) and CD86 (B7-2). Recently, CD80 and CD86 have been implicated as differential determinants of Th1-
Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 CD95)-induced apoptosis and preservation of a T helper 1 phenotype.: J Immunol. 1997 Mar 15;158(6):2964-76. Unique Identifier : AIDSLINE MED/97211869; Gougeon ML; Lecoeur H; Boudet F; Ledru E; Marzabal S; Boullier S; Roue R; Nagata S; Heeney J; Department of AIDS and Retroviruses, Pasteur Institute, Paris, France.; Chimpanzees are one of the few species, along with humans, susceptible to persistent HIV-1 infection. However, HIV-infected chimpanzees do not exhibit the marked immune system alterations seen in humans and remain relatively resistant to AIDS. In humans, HIV infection leads to unresponsiveness of T cells in response t
The integrin-triggered rescue of T lymphocyte apoptosis is blocked in HIV-1-infected individuals.: J Immunol. 1997 Mar 15;158(6):2984-99. Unique Identifier : AIDSLINE MED/97211871; Ng TT; Kanner SB; Humphries MJ; Wickremasinghe RG; Nye KE; Anderson J; Khoo SH; Morrow WJ; Department of Immunology, St. Bartholomew's and Royal London School of; Medicine and Dentistry, United Kingdom.; HIV infection is associated with a disease status-dependent impairment of Ag-specific T cell responses, resulting in anergy or unchecked apoptotic cell death. beta1 integrins play an important role in the induction of T lymphocyte responses to antigenic challenge by providing a T cell costimulatory signal, and have be
Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease.: J Immunol. 1997 Mar 15;158(6):3009-16. Unique Identifier : AIDSLINE MED/97211873; Segal R; Bermas BL; Dayan M; Kalush F; Shearer GM; Mozes E; Department of Immunology, The Weizmann Institute of Science, Rehovot,; Israel.; We followed cytokine production from induction through disease progression in a murine model of experimental systemic lupus erythematosus (SLE). SLE was induced by immunization with the human monoclonal anti-DNA Ab that bears the common Id designated 16/6 Id. BALB/c and C3H.SW mice that are susceptible to SLE inductio
A malignant astrocytoma in a patient with AIDS: a possible association between astrocytomas and HIV infection.: J Infect. 1996 Nov;33(3):159-62. Unique Identifier : AIDSLINE MED/97101176; Neal JW; Llewelyn MB; Morrison HL; Jasani B; Borysiewicz LK; Department of Histopathology, University Hospital of Wales, College of; Medicine, Cardiff, U.K.; We describe a malignant astrocytoma in a patient with AIDS confirmed at autopsy. The object of this report is to draw attention to a further example of an unusual tumour associated with HIV infection. This is the tenth case in the world literature and it is possible that this tumour is represented with a higher than e
A comparison of two methods of gene amplification for the diagnosis of Toxoplasma gondii in AIDS.: J Infect. 1996 Nov;33(3):177-83. Unique Identifier : AIDSLINE MED/97101180; Nicoll S; Burns SM; Brettle RP; Leen CS; Centre for Tropical Veterinary Medicine, Edinburgh University, Roslin,; Midlothian, U.K.
Response to oral and intravenous azithromycin in a patient with toxoplasma encephalitis and AIDS.: J Infect. 1996 Nov;33(3):227-9. Unique Identifier : AIDSLINE MED/97101188; Wiselka MJ; Read R; Finch RG; Department of Infectious Diseases and Tropical Medicine, Leicester; Royal Infirmary, U.K.; We present a patient with AIDS and toxoplasma encephalitis who was unable to tolerate established therapy with sulphadiazine or clindamycin but responded to oral azithromycin and pyrimethamine. The patient was maintained on oral azithromycin but subsequently relapsed after 8 months. The recurrence was successfully tre
Cryptococcal dermatitis with negative antigenaemia heralding disseminated disease in HIV infection [letter]: J Infect. 1996 Nov;33(3):240-1. Unique Identifier : AIDSLINE MED/97101192; Soldani F; Lanzafame M; Allegranzi B; Bonora S; Tessari G; Di Perri G; Concia E
Cytokine production by dengue virus antigen-responsive human T lymphocytes in vitro examined using a double immunocytochemical technique.: J Leukoc Biol. 1997 Mar;61(3):338-45. Unique Identifier : AIDSLINE MED/97213768; Mori M; Kurane I; Janus J; Ennis FA; Department of Medicine, University of Massachusetts Medical School,; Worcester 01655, USA.; A number of studies suggest that cytokines may contribute to the pathogenesis of viral infections, including dengue. In this study, we developed a double immunocytochemical method and characterized cytokine-producing cells in the peripheral blood mononuclear cells (PBMC) of dengue virus-immune donors after in vitro st
Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity.: J Leukoc Biol. 1997 Mar;61(3):346-52. Unique Identifier : AIDSLINE MED/97213769; Maruo S; Ahn HJ; Yu WG; Tomura M; Wysocka M; Yamamoto N; Kobayashi M; Hamaoka T; Trinchieri G; Fuijiwara H; Biomedical Research Center, Osaka University Medical School, Suita,; Japan.; We previously demonstrated that proliferation of terminally differentiated Th1 clones depends primarily on an interleukin-12 IL-12)-paracrine mechanism mediated by their interactions with antigen-presenting cells (APC) rather than on an IL-2-autocrine mechanism. Such a Th1 clone (4-86, C57BL/6 origin) was cultured wit
Virus load in chimpanzees infected with human immunodeficiency virus type 1: effect of pre-exposure vaccination.: J Gen Virol. 1995 Apr;76 ( Pt 4):1015-20. Unique Identifier : AIDSLINE MED/97201565; ten Haaft P; Cornelissen M; Goudsmit J; Koornstra W; Dubbes R; Niphuis H; Peeters M; Thiriart C; Bruck C; Heeney JL; Laboratory of Viral Pathogenesis, Biomedical Primate Research Centre,; Rijswijk, the Netherlands.; Many reports indicate that a long-term asymptomatic state following human immunodeficiency virus type 1 (HIV-1) infection is associated with a low amount of circulating virus. To evaluate the possible effect of stabilizing a low virus load by non-sterilizing pre-exposure vaccination, a quantitative virus isolation met
Human T cell leukaemia virus type I env gene-transfected HeLa cells display a decrease in cell fusion ability.: J Gen Virol. 1995 Apr;76 ( Pt 4):1021-4. Unique Identifier : AIDSLINE MED/97201566; Girerd Y; Casse H; Duc Dodon M; Gazzolo L; Immuno-Virologie Moleculaire et Cellulaire, UMR30, Centre National de; la Recherche Scientifique, Universite Claude Bernard Lyon I, France.; The envelope (env) gene of human T cell leukaemia virus type I HTLV-I) was inserted into an expression vector, referred to as phMTenv, under the transcriptional control of the human metallothionein IIa gene promoter (hMT-IIa). When this vector was transiently transfected in HeLa cells treated with hMT-IIa inducers, fo
The human immunodeficiency virus type 1 Nef protein functions as a protein kinase C substrate in vitro.: J Gen Virol. 1995 Apr;76 ( Pt 4):837-44. Unique Identifier : AIDSLINE MED/97201543; Coates K; Harris M; MRC Retrovirus Research Laboratory, Department of Veterinary; Pathology, University of Glasgow, UK.; The human immunodeficiency virus type 1 Nef protein was expressed in Escherichia coli as a C-terminal fusion with glutathione S-transferase (GST). The ability of GST-Nef to act as a substrate for cellular kinases in vitro was examined by incubation of purified GST-Nef fusion proteins, immobilized on glutathione-agaros
Revertants and pseudo-revertants of human immunodeficiency virus type 1 viruses mutated in the long terminal repeat promoter region.: J Gen Virol. 1995 Apr;76 ( Pt 4):845-53. Unique Identifier : AIDSLINE MED/97201544; Berkhout B; Klaver B; Department of Virology, University of Amsterdam Academic Medical; Centre, The Netherlands.; The TAR domain is an RNA secondary structure element within the leader transcript of the human immunodeficiency virus type 1 HIV-1) virus. TAR RNA forms the binding site for the viral trans-activator protein Tat and cellular co-factors that are involved in induction of the LTR transcriptional promoter. Here, we report
Coronavirus-induced encephalomyelitis: balance between protection and immune pathology depends on the immunization schedule with spike protein S.: J Gen Virol. 1995 Apr;76 ( Pt 4):873-9. Unique Identifier : AIDSLINE MED/97201547; Flory E; Stuhler A; Barac-Latas V; Lassmann H; Wege H; Institute of Virology and Immunobiology, University of Wurzburg,; Germany.; The neurotropic mouse hepatitis virus MHV-JHM induces central nervous system (CNS) demyelination in Lewis rats that pathologically resembles CNS lesions in multiple sclerosis. The mechanisms of MHV-JHM-induced demyelination remain unclear and several studies have implicated the role of the immune response in this proc
Adelaide River virus nucleoprotein gene: analysis of phylogenetic relationships of ephemeroviruses and other rhabdoviruses.: J Gen Virol. 1995 Apr;76 ( Pt 4):995-9. Unique Identifier : AIDSLINE MED/97201562; Wang Y; Cowley JA; Walker PJ; CSIRO Division of Tropical Animal Production, Indooroopilly,; Queensland, Australia.; The nucleotide sequence of the Adelaide River virus (ARV) genome was determined from the 3 terminus to the end of the nucleoprotein (N) gene. The 3 leader sequence comprises 50 nucleotides and shares a common terminal trinucleotide (3 UGC-), a conserved U-rich domain and a variable AU-rich domain with other animal
Long-term evolution of the 5'UTR and a region of NS4 containing a CTL epitope of hepatitis C virus in two haemophilic patients.: J Gen Virol. 1997 Mar;78 ( Pt 3):583-90. Unique Identifier : AIDSLINE MED/97201623; Devereux HL; Brown D; Dusheiko GM; Emery VC; Lee CA; The Haemophilia Centre, Haematology Department, Royal Free Hospital,; London, UK.; Haemophilic patients exposed to unsterilized clotting factor concentrates prior to 1985 have become infected with hepatitis C virus (HCV). We have studied the sequence evolution of the 5 UTR and a region of NS4 over 12 years in one human immunodeficiency virus (HIV) positive haemophilic patient and 14 years for one HI
Inhibition of feline immunodeficiency virus infection by CD9 antibody operates after virus entry and is independent of virus tropism.: J Gen Virol. 1997 Mar;78 ( Pt 3):611-8. Unique Identifier : AIDSLINE MED/97201626; Willett B; Hosie M; Shaw A; Neil J; Department of Veterinary Pathology, University of Glasgow, UK.; b.willett@vet.gla.ac.uk; A monoclonal antibody which blocks infection with feline immunodeficiency virus (FIV) was found previously to react with the cell surface molecule CD9, implicating CD9 in the process of virus entry. We report here that inhibition by anti-CD9 antibody does not operate at the level of virus entry but at a subsequent sta
Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.: J Gen Virol. 1997 Mar;78 ( Pt 3):619-25. Unique Identifier : AIDSLINE MED/97201627; Fujita K; Omura S; Silver J; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; Human immunodeficiency virus (HIV) type 1 encodes three genes, Vpu, Env and Nef, that decrease cellular CD4. Vpu and Env act cooperatively to accelerate degradation of CD4 in the endoplasmic reticulum. Here we report that Vpu/Env-induced CD4 degradation is inhibited by lactacystin, a specific inhibitor of the proteaso
Analysis of vif-defective human immunodeficiency virus type 1 HIV-1) virions synthesized in 'non-permissive' T lymphoid cells stably infected with selectable HIV-1.: J Gen Virol. 1997 Mar;78 ( Pt 3):627-35. Unique Identifier : AIDSLINE MED/97201628; Ochsenbauer C; Wilk T; Bosch V; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.; In order to facilitate analyses of the molecular function of the human immunodeficiency virus type 1 (HIV-1) Vif protein, we have developed a cell culture model-system which allows permanent production of genotypically and phenotypically vif-defective HIV-1 virions in non-permissive H9 cells. Using recombinant, repl
The major homology region of bovine leukaemia virus p24gag is required for virus infectivity in vivo.: J Gen Virol. 1997 Mar;78 ( Pt 3):637-40. Unique Identifier : AIDSLINE MED/97201629; Willems L; Kerkhofs P; Attenelle L; Burny A; Portetelle D; Kettmann R; Molecular Biology Unit, Faculty of Agronomy, Gembloux, Belgium.; In order to gain insight into the role of the major homology region (MHR) in the infectious potential of bovine leukaemia virus (BLV), mutations were introduced into the capsid gene of an infectious molecular clone. A provirus that was designed to contain only a slightly modified version of the MHR (substitution of ph
Molecular subtyping of human T-lymphotropic virus type I (HTLV-I) by a nested polymerase chain reaction-restriction fragment length polymorphism analysis of the envelope gene: two distinct lineages of HTLV-I in Taiwan.: J Med Virol. 1997 Jan;51(1):25-31. Unique Identifier : AIDSLINE MED/97140464; Yang YC; Hsu TY; Liu MY; Lin MT; Chen JY; Yang CS; Graduate Institute of Microbiology, College of Medicine, National; Taiwan University, Republic of China.; The major type of human T-lymphotropic virus type I (HTLV-I), generally referred to as the cosmopolitan type, has been grouped into three subtypes (A, B, and C) by phylogenetic analysis of the long terminal repeat sequences of the viral genome. Twelve subtype-specific nucleotide variations have been deduced by compari
Hepatitis C virus genotypes in French haemophiliacs: kinetics and reappraisal of mixed infections.: J Med Virol. 1997 Jan;51(1):36-41. Unique Identifier : AIDSLINE MED/97140466; Tuveri R; Rothschild C; Pol S; Reijasse D; Persico T; Gazengel C; Brechot C; Thiers V; INSERM U370, Chu Necker and CBMS, Pasteur Institue, Paris, France.; The distribution and kinetics of hepatitis C virus (HCV) genotypes and the prevalence of mixed infections were studied in a group of 45 French patients with haemophilia A or B or von Willebrand s disease, 21 of them being anti-human immunodeficiency virus (HIV) positive; genotyping was carried out by three methods bas
Comparison between vaginal tampon and cervicovaginal lavage specimen collection for detection of human papillomavirus DNA by the polymerase chain reaction. The Canadian Women's HIV Study Group.: J Med Virol. 1997 Jan;51(1):42-7. Unique Identifier : AIDSLINE MED/97140467; Coutlee F; Hankins C; Lapointe N; Department de Microbiologie-Immunologie, Universite de Montreal,; Quebec, Canada.; The aim of the study was to compare the accuracy of self-administered vaginal tampon (VT) specimens for the detection of human papillomaviruses (HPVs) with that of cervicovaginal lavage specimens (CVL). Two hundred seventy-four paired VT and CVL specimens were collected prospectively from women at risk of sexually tra
Additional mutations detected in sequential HIV-1 isolates from ZDV-treated patients.: J Med Virol. 1997 Jan;51(1):48-55. Unique Identifier : AIDSLINE MED/97140468; Magierowska-Jung M; Agut H; Katlama C; Autran B; Huraux JM; Laboratoire de Virologie CNRS EP 57. CERVI, Hopital Pitie-Salpetriere,; Paris, France.; Sequential isolates from four patients under zidovudine (ZDV) therapy were obtained using PBMC coculture in the absence or in the presence of 0.25 microM ZDV. PBMC-based HIV susceptibility assay demonstrated the emergence of ZDV-resistance in the sequential isolates from the four patients. Except in one case, the isol
Improved methods for quantification of human immunodeficiency virus type 1 RNA and hepatitis C virus RNA in blood using spin column technology and chemiluminescent assays of PCR products.: J Med Virol. 1997 Jan;51(1):56-63. Unique Identifier : AIDSLINE MED/97140469; Lin HJ; Tanwandee T; Hollinger FB; Division of Molecular Virology, Baylor College of Medicine, Houston,; Texas 77030, USA.; The quantification of human immunodeficiency virus type 1 (HIV-1) RNA or hepatitis C virus (HCV) RNA has been facilitated by adapting a spin column procedure for sample preparation and the use of chemiluminescent detection of polymerase chain reaction PCR) products in microtiter plate format. All materials were commer
Temporary seronegativity in a human immunodeficiency virus type 1-infected man.: J Med Virol. 1997 Jan;51(1):80-2. Unique Identifier : AIDSLINE MED/97140472; Zaaijer HL; Bloemer MH; Lelie PN; Clinical Microbiology and Infection Control, University Hospital Vrije; Universiteit, Amsterdam, The Netherlands.; Over a period of 3 months a human immunodeficiency virus 1 HIV-1)-infected patient showed a sequence of positive-negative-positive anti-HIV screening test results. During this period the level of HIV p24 antigen declined and the HIV antibody pattern by Western blot gradually became complete, suggesting recent HIV infe
Fatal brain stem encephalitis due to herpes simplex virus type 1 in AIDS [letter]: J Neurol. 1996 Jun;243(6):491-3. Unique Identifier : AIDSLINE MED/96396724; Moulignier A; Baudrimont M; Martin-Negrier ML; Mikol J; Lapresle C; Dupont B
A comparison of brain biopsy and CSF-PCR in the diagnosis of CNS lesions in AIDS patients.: J Neurol. 1997 Jan;244(1):35-9. Unique Identifier : AIDSLINE MED/97160227; d'Arminio Monforte A; Cinque P; Vago L; Rocca A; Castagna A; Gervasoni C; Terreni MR; Novati R; Gori A; Lazzarin A; Moroni M; Infectious Diseases Clinic, L Sacco Hospital, Milan, Italy.; Twenty patients with AIDS who had intracranial lesions underwent both brain biopsy and cerebrospinal fluid (CSF) examination to compare histological diagnosis with the polymerase chain reaction CSF-PCR) for the identification of infectious agents. CSF-PCR was performed for herpes simplex virus, varicella zoster virus,
Mitoguazone therapy in patients with refractory or relapsed AIDS-related lymphoma: results from a multicenter phase II trial.: J Clin Oncol. 1997 Mar;15(3):1094-103. Unique Identifier : AIDSLINE MED/97213861; Levine AM; Tulpule A; Tessman D; Kaplan L; Giles F; Luskey BD; Scadden DT; Northfelt DW; Silverberg I; Wernz J; Espina B; Von Hoff D; University of Southern California School of Medicine, Los Angeles; 90033, USA. hornor@hsc.usc.edu; PURPOSE: Patients with AIDS-related lymphoma usually have extensive lymphomatous disease, with relatively frequent involvement of the CNS. Approximately half may achieve complete remission after chemotherapy. Mitoguazone, an inhibitor of polyamine biosynthesis, has demonstrated efficacy in patients with de novo recurr
AIDS-related Kaposi's sarcoma.: J Clin Oncol. 1997 Mar;15(3):1283-4. Unique Identifier : AIDSLINE MED/97213884; van den Brink MR; Dezube BJ; AIDS Malignancy Research and Treatment Center, Beth Israel Deaconess; Medical Center, Boston, MA, USA.
In vitro inhibitory activity of citreoviridin against HIV-1 and an HIV-associated opportunist: Candida albicans.: J Chemother. 1996 Oct;8(5):351-7. Unique Identifier : AIDSLINE MED/97116626; Vieta I; Savarino A; Papa G; Vidotto V; Cantamessa C; Pugliese A; Department of Medical and Surgical Sciences, University of Turin,; Italy.; Citreoviridin, a mycotoxin produced by some molds of the genera Penicillium and Aspergillus, inhibits the growth of bacteria of the Bacillus genus. Since significant information was not available on the effects of citreoviridin on eukaryotic cells and viruses, this molecule was tested on CD4+ T-lymphoid cell lines, on
Experience with adriamycin, bleomycin, vincristine (ABV) palliative chemotherapy in advanced AIDS-related Kaposi's sarcoma.: J Chemother. 1996 Oct;8(5):403-6. Unique Identifier : AIDSLINE MED/97116635; Paparizos VA; Kyriakis KP; Mileounis KA; Pfandl-Polydorou D; Stavrianeas NG; Vareltzidis AG; Stratigos JD; Dept. of Dermatology, Andreas Sygros Hospital, University of Athens,; Greece.; After administration of Adriamycin, bleomycin, vincristine (ABV) as palliative chemotherapy in advanced AIDS-related Kaposi s sarcoma (AIDS.KS) patients with low Karnosfsky performance scores, the authors attempted to estimate the overall biological cost/benefit relating to the disease. The authors analyzed data from
The actions of polynucleotides on effector stage cloned murine T-helper cells differ in each subset and depend on antigen concentration.: J Nutr. 1997 Mar;127(3):411-7. Unique Identifier : AIDSLINE MED/97228054; Jyonouchi H; Sun S; Department of Pediatrics, School of Medicine, University of Minnesota,; Minneapolis 55455, USA.; Polynucleotides enhance T-helper (Th) cell-mediated humoral immune responses in naive resting Th cells, B cells, and antigen-presenting cells (APC) from unprimed mouse spleen. If polynucleotides augment Th cell functions independent of the activation stage of Th cells, then polynucleotides may cause hyperimmune respon
Apoptosis of human monocytes/macrophages in Mycobacterium tuberculosis infection.: J Pathol. 1997 Jan;181(1):31-8. Unique Identifier : AIDSLINE MED/97225658; Placido R; Mancino G; Amendola A; Mariani F; Vendetti S; Piacentini M; Sanduzzi A; Bocchino ML; Zembala M; Colizzi V; Department of Biology University of Rome Tor Vergata, Italy.; Tuberculosis (TB) is still a major health problem, both as a single disease entity and as a cofactor in AIDS. The interaction between macrophage and Mycobacterium tuberculosis (MTB) is a critical step in the establishment of an early chronic infection. This study analyses the capacity of MTB to induce apoptosis in cel
Endoscopic retrograde cholangiopancreatography in children with HIV infection.: J Pediatr Gastroenterol Nutr. 1996 Dec;23(5):624-7. Unique Identifier : AIDSLINE MED/97138873; Yabut B; Werlin SL; Havens P; Bohorfoush A; Brown CW; Harb J; Department of Pediatrics (Division of Gastroenterology and Infectious; Diseases), Medical College of Wisconsin, Milwaukee 53226, USA.
Correlates of psychological distress among mothers of children and adolescents with hemophilia and HIV infection.: J Pediatr Psychol. 1997 Feb;22(1):1-14. Unique Identifier : AIDSLINE MED/97171875; Drotar D; Agle DP; Eckl CL; Thompson PA; Case Western Reserve University School of Medicine, Cleveland, Ohio,; USA.; Evaluated the correlates of mood state (psychological distress) in a multisite study of two groups: (a) mothers of HIV-positive children and adolescents with hemophilia (n = 91), and (b) mothers of HIV-negative children and adolescents with hemophilia n = 92). Socioeconomic status, quality of family relationship suppo
Brief report: HIV-exposed newborns show inferior orienting and abnormal reflexes on the Brazelton Scale.: J Pediatr Psychol. 1997 Feb;22(1):105-12. Unique Identifier : AIDSLINE MED/97171882; Scafidi F; Field T; Touch Research Institute, University of Miami School of Medicine,; Florida 33101, USA.; Assessed 48 infants of HIV-positive and HIV-negative mothers on the Brazelton Neonatal Behavioral Assessment Scale. Infants exposed to HIV-positive mothers were disadvantaged from birth due to their mothers having obstetric complications and to the infants having orienting problems and abnormal reflexes on the Brazelt
Cell-mediated immunity in host resistance against infection caused by Penicillium marneffei.: J Med Vet Mycol. 1996 Nov-Dec;34(6):371-8. Unique Identifier : AIDSLINE MED/97126731; Kudeken N; Kawakami K; Kusano N; Saito A; First Department of Internal Medicine, Faculty of Medicine, University; of the Ryukyus, Okinawa, Japan.; Penicillium marneffei is one of the most important opportunistic infectious pathogens in AIDS patients in Thailand and Southeast Asia. However, very little is known about the host defence mechanisms against P. marneffei infection. In the present study, we established the first ex
Cladophialophora bantiana isolated from an AIDS patient with pulmonary infiltrates.: J Med Vet Mycol. 1996 Nov-Dec;34(6):427-9. Unique Identifier : AIDSLINE MED/97126739; Brenner SA; Morgan J; Rickert PD; Rimland D; Division of Infectious Disease, Emory University School of Medicine,; Atlanta, GA, USA.; Cladophialophora bantiana causes a rare phaeohyphomycosis, usually manifested by brain abscesses but rarely by skin or pulmonary lesions. It has not been reported as a common colonizer or as a cause of pulmonary symptoms in patients with AIDS. We present a case in which C. bantiana was repeatedly isolated from the spu
Oral cryptococcosis: case report of salivary gland involvement in an AIDS patient.: J Oral Pathol Med. 1997 Jan;26(1):53-6. Unique Identifier : AIDSLINE MED/97173655; Monteil RA; Hofman P; Michiels JF; Loubiere R; Laboratoire de Pathobiologie Orale, Universite de Nice, France.; Salivary cryptococcosis was disclosed at autopsy in an AIDS patient with disseminated C. neoformans infection. H & E staining was not suitable to demonstrate the occurrence of C. neoformans in many tissues; Alcian blue gave the best results.
Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site.: J Mol Biol. 1997 Feb 14;266(1):31-9. Unique Identifier : AIDSLINE MED/97207675; Ghiara JB; Ferguson DC; Satterthwait AC; Dyson HJ; Wilson IA; Department of Molecular Biology, Scripps Research Institute, La Jolla,; CA 92037, USA.; Antigenic variation among different HIV-1 isolates has been a major problem in the development of an effective vaccine against AIDS. Peptide vaccines incorporating structural elements common to groups of viral isolates, such as the clade subtypes of HIV-1, hold promise; however, the design of such immunogens has been
From the Centers for Disease Control and Prevention. Update: trends in AIDS incidence, deaths, and prevalence--United States, 1996.: JAMA. 1997 Mar 19;277(11):874-5. Unique Identifier : AIDSLINE MED/97216023
From the Centers for Disease Control and Prevention. Community-based HIV prevention in presumably underserved populations--July-September 1995.: JAMA. 1997 Mar 19;277(11):876-7. Unique Identifier : AIDSLINE MED/97216024
[Opportunistic lymphoma]: Nippon Rinsho. 1997 Feb;55(2):441-5. Unique Identifier : AIDSLINE MED/97198822; Katano H; Mori S; Department of Pathology, University of Tokyo.; Malignant lymphoma is one of the most common complications in patients under immunodeficiency. Such lymphomas, termed as opportunistic lymphoma, are growing in these days because of the high prevalence of AIDS and the wide introduction of organ/bone marrow transplantation. The Epstein-Barr virus has been regarded as t
[Current diagnosis and prognostic importance of EBV-associated neoplasms]: Nippon Rinsho. 1997 Feb;55(2):446-51. Unique Identifier : AIDSLINE MED/97198823; Kawa K; Osaka Medical Center.; In addition to endemic Burkitt s lymphoma and nasopharyngeal carcinoma a variety of other epithelial-and lymphoid-derived proliferative diseases has been shown to closely link with Epstein-Barr virus (EBV) infection. The former include thymic lymphoepithelial carcinoma, oral hairy leukoplakia and gastric carcinoma. Th
Pathology of acquired immunodeficiency syndrome (AIDS) in children.: Keio J Med. 1996 Dec;45(4):306-12. Unique Identifier : AIDSLINE MED/97175856; Joshi VV; Department of Pathology, Hartford Hospital, CT 06102, USA.; OVERVIEW: Acquired Immunodeficiency Syndrome (AIDS) was first described to occur in children in 1983. With experience of increasing number of cases of AIDS, pathologic lesions in various organs and tissues such as lungs, brain, G.I. tract, heart, blood vessels, lymph nodes, spleen, bone marrow, etc. became evident in
[Treatment of AIDS and associated diseases]: Klin Med (Mosk). 1997;75(1):5-10. Unique Identifier : AIDSLINE MED/97208338; Rytik PG; NII of Epidemiology and Microbiology, Minsk, Byelorussia.
Increased enzyme-linked immunosorbent assay specificity with solubilized simian retrovirus 2-infected cell membranes.: Lab Anim Sci. 1996 Dec;46(6):619-22. Unique Identifier : AIDSLINE MED/97154455; Thouless ME; Wang Y; Welch MJ; Department of Pathobiology, University of Washington, Seattle; 98195-7238, USA.; Simian type-D retrovirus (SRV) infection is a health problem in captive and wild-caught macaques; it interferes with acquired immune deficiency syndrome-related research. Because the enzyme-linked immunosorbent assay (ELISA) with gradient-purified SRV-2 virus yields a high percentage of false-positive results, the ass
Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations.: J Theor Biol. 1997 Jan 21;184(2):203-17. Unique Identifier : AIDSLINE MED/97212780; Nowak MA; Bonhoeffer S; Shaw GM; May RM; Department of Zoology, University of Oxford, U.K.; Anti-viral drug treatment of infections with the human immunodeficiency virus type I (HIV-1) usually leads to a rapid decline in the abundance of plasma virus. The effect of single drug therapy, however, is often only short-lived as the virus readily develops drug-resistant mutants. In this paper we provide analytic a
[Usefulness of cerebral biopsy in focal cerebral lesions in patients with human immunodeficiency virus infection]: Med Clin (Barc). 1996 Nov 30;107(19):738-41. Unique Identifier : AIDSLINE MED/97138954; Cordero E; Lara C; Canas E; Romero J; Trujillo F; Chinchon I; Pachon J; Departamento de Anatomia Patologica, Hospital Universitario Virgen del; Rocio, Sevilla.; Brain mass lesions (BML) occurred in 10% of patients infected by the human immunodeficiency virus (HIV), as expression of severe and sometimes treatable diseases. However, the management of them is not well established. We analyzed, retrospectively, 26 brain biopsies (22 estereotaxic) in patients with HIV infection an
[Effect of treatment with nucleoside analogues in subjects with primary genotypic resistance to zidovudine (letter)]: Med Clin (Barc). 1996 Nov 30;107(19):755. Unique Identifier : AIDSLINE MED/97138957; Leal M; Caruz A; Rey C; Lissen E
Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity.: Metabolism. 1997 Mar;46(3):303-5. Unique Identifier : AIDSLINE MED/97206981; Yarasheski KE; Zachwieja JJ; Horgan MM; Powderly WG; Santiago JV; Landt M; Division of Endocrinology, Washington University School of Medicine,; St Louis, MO 63110, USA.; The product of the obese gene (ob) is the protein leptin, which is synthesized in and secreted from adipocytes. Fasting serum leptin concentrations are closely related to body fat content and are higher in obese than in normal-weight individuals. Leptin may contribute to body weight regulation. Overproduction of lepti
Searching for answers on a clinical information system.: Methods Inf Med. 1995 Mar;34(1-2):79-84. Unique Identifier : AIDSLINE MED/97227853; Safran C; Center for Clinical Computing, Beth Israel Hospital, Harvard Medical; School, Boston, MA, USA.; We examined observational data on the use of a clinical computing system in an effort to develop an empirical model of clinicians information needs. Clinicians turn to information systems most often to review the results of diagnostic studies. After that, clinicians turn to information systems most often for communic
Subpopulations of T lymphocytes in the peripheral blood and lymph nodes of Indian kala-azar patients.: Med Microbiol Immunol (Berl). 1996 Nov;185(3):183-7. Unique Identifier : AIDSLINE MED/97160308; Ghosh MK; Ghosh AK; Addy M; Nandy A; Ghose AC; Department of Microbiology, Bose Institute, Calcutta, India.; Distribution of T cells in the peripheral blood and lymph nodes of Indian kala-azar (KA) patients was studied by using appropriate phenotypic markers for CD2+, CD4+ and CD8+ cells. Significant reduction in the CD2+, CD4+ cell numbers as well as CD4+/CD8+ cell ratio was noted in the peripheral blood of active KA cases.
Identification of a human endogenous LTR-like sequence using HIV-1 LTR specific primers.: Mol Cell Probes. 1996 Dec;10(6):443-51. Unique Identifier : AIDSLINE MED/97177566; Menin C; Indraccolo S; Montagna M; Corneo B; Bonaldi L; Leib-Mosch C; Chieco-Bianchi L; D'Andrea E; Istituto di Oncologia, University of Padova, Italy.; Using consensus primers derived from the LTR region of 15 HIV-1 isolates, a fragment of 583 bp was amplified from human DNA. Even though specificity was confirmed by Southern blot analysis with a conserved LTR oligonucleotide probe, no significant homologies were detected to either retroviral regions or human or non
Analysis of Epstein-Barr virus (EBV) type and variant in spontaneous lymphoblastoid cells and Hu-SCID mouse tumours.: Mol Cell Probes. 1996 Dec;10(6):453-61. Unique Identifier : AIDSLINE MED/97177567; Menin C; Ometto L; Veronesi A; Roncella S; Corneo B; Montagna M; Coppola V; Veronese ML; Indraccolo S; Amadori A; De Rossi A; Ferrarini M; Chieco-Bianchi L; D'Andrea E; Institute of Oncology, University of Padova, Italy.; Epstein-Barr virus (EBV) type and strain variations were examined using both lymphoblastoid cell lines (LCLs), spontaneously derived in vitro from peripheral blood mononuclear cells (PBMC) of 15 HIV-1-seropositive individuals; and SCID mouse tumours induced by inoculation of PBMC from 11 healthy human donors Hu-SCID t
A simplified semiquantitative determination of hepatitis C virus genome molecules by the end-point dilution method.: Mol Cell Probes. 1996 Dec;10(6):477-80. Unique Identifier : AIDSLINE MED/97177572; Bathelier C; Mercier G; Lucotte G; LCL Laboratory, Paris, France.; We describe a semiquantitative method to measure hepatitis C virus (HCV) viral particle numbers, by carrying out reverse-transcription polymerase chain reaction (RT-PCR) on serial dilutions of serum samples. The virus concentrations measured were 10(3)-10(6) viral particles ml-1 of serum. The method described is relat
Assessment of HIV risk outcomes in clinical trials for substance abuse pharmacology.: NIDA Res Monogr. 1996;162:46-8. Unique Identifier : AIDSLINE MED/97219510
Diagnosis of AIDS-related focal brain lesions: a decision-making analysis based on clinical and neuroradiologic characteristics combined with polymerase chain reaction assays in CSF.: Neurology. 1997 Mar;48(3):687-94. Unique Identifier : AIDSLINE MED/97217888; Antinori A; Ammassari A; De Luca A; Cingolani A; Murri R; Scoppettuolo G; Fortini M; Tartaglione T; Larocca LM; Zannoni G; Cattani P; Grillo R; Roselli R; Iacoangeli M; Scerrati M; Ortona L; Department of Infectious Diseases, Catholic University, Rome, Italy.; OBJECTIVE: To identify disease patterns in AIDS-related focal brain lesions (FBL) and to design a decision-making strategy for differential diagnosis. DESIGN: Prospective study. Probabilities of CNS disorders were calculated using Bayes theorem according to clinical variables (mass effect at CT or MRI, Toxoplasma ser
Sexually transmitted disease control in the armed forces, past and present.: Mil Med. 1997 Feb;162(2):87-91. Unique Identifier : AIDSLINE MED/97189935; Emerson LA; School of Medicine, University of Colorado Health Sciences Center,; Denver 80262, USA.; Sexually transmitted diseases (STDs) present a challenge for military medical personnel in their efforts to maintain a ready and healthy force. Many tactics have been used in military STD control programs. This paper is a review of the literature outlining some past strategies used in the
Electroretinographic and psychophysical findings during early and late stages of human immunodeficiency virus infection and cytomegalovirus retinitis.: Ophthalmology. 1997 Mar;104(3):445-53. Unique Identifier : AIDSLINE MED/97226427; Latkany PA; Holopigian K; Lorenzo-Latkany M; Seiple W; Department of Ophthalmology, NYU Medical Center, NY 10016, USA.; PURPOSE: The authors examined electrophysiologic and psychophysical measures of retinal function in patients infected with human immunodeficiency virus (HIV) at different stages of infection, including patients with cytomegalovirus retinitis CMVR). METHODS: All patients had complet
Anterior nongranulomatous uveitis after intravitreal HPMPC cidofovir) for the treatment of cytomegalovirus retinitis. Analysis and prevention [published erratum appears in Ophthalmology 1997 Jul;104(7):1063]: Ophthalmology. 1997 Mar;104(3):539-44. Unique Identifier : AIDSLINE MED/97226442; Chavez-de la Paz E; Arevalo JF; Kirsch LS; Munguia D; Rahhal FM; De Clercq E; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California San Diego, La Jolla 92093-0946, USA.; BACKGROUND AND OBJECTIVE: The authors characterize and analyze the incidence of a previously reported mild anterior nongranulomatous uveitis associated with intravitreal injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC), also termed cidofovir (Vistide, Gilead Sci
Cell lines containing and expressing the human herpesvirus 6A ts gene are protected from both H-ras and BPV-1 transformation.: Oncogene. 1997 Feb 27;14(8):937-43. Unique Identifier : AIDSLINE MED/97203275; Araujo JC; Doniger J; Stoppler H; Sadaie MR; Rosenthal LJ; Department of Microbiology and Immunology and Vincent T Lombardi; Cancer center, Georgetown University Medicial Center, Washington, DC; 20007, USA.; Human herpesvirus 6A (HHV-6A) strain U1102 was previously shown to contain a 1473 bp transformation suppressor gene (ts) (Araujo et al., 1995). Ts inhibited transformation of NIH3T3 cells by H-ras and transcription of the H-ras and human immunodeficiency type 1 (HIV-1) promoters in transient transfection experiments.
Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586), an extremely hydrophobic diprotic acid.: Pharm Res. 1996 Oct;13(10):1453-9. Unique Identifier : AIDSLINE MED/97055547; Venkatesh S; Li J; Xu Y; Vishnuvajjala R; Anderson BD; Department of Pharmaceutics and Pharmaceutical Chemistry, University; of Utah, Salt Lake City 84112, USA.; PURPOSE: The selection of cosalane (NSC 658586) by the National Cancer Institute for further development as a potential drug candidate for the treatment of AIDS led to the exploration of the solubility behavior of this extremely hydrophobic drug, which has an intrinsic solubility (S0 approaching 1 ng/ml. This study de
[Salmonella typhimurium cerebral abscess in a patient with HIV infection (letter)]: Presse Med. 1996 Dec 21;25(40):2052. Unique Identifier : AIDSLINE MED/97226627; Gueit I; Bani-Sadr F; Borsa-Lebas F; Caron F; Langlois O; Humbert G
[Renal involvement in HIV-1 infection]: Presse Med. 1997 Feb 1;26(2):91-5. Unique Identifier : AIDSLINE MED/97226588; Nochy D; Laboratoire d'Anatomopathologie, U 430, Hopital Broussais, Paris.
[Herpes simplex virus and varicella-zoster virus infections in HIV-infected patients]: Presse Med. 1997 Jan;26 Suppl 1:10-2. Unique Identifier : AIDSLINE MED/97226547; Leport C; Brun-Vezinet F; Service des-Maladies infectieuses et tropieales Centre Hospitalier; Bichat-Claude Bernard, Paris.
[Cytomegalovirus infections in HIV infection]: Presse Med. 1997 Jan;26 Suppl 1:13-5. Unique Identifier : AIDSLINE MED/97226548; Matheron S; Service des Maladies infectieuses et troplcates, Centre Hospitalier; Bichat-Claude Bernard, Paris.
[Human herpesvirus 8 infections]: Presse Med. 1997 Jan;26 Suppl 1:16-8. Unique Identifier : AIDSLINE MED/97226549; Agut H; Hopital de la Pitie-Salpetriere, Paris.
[New drugs for treatment of HIV infection receive europewide approval]: Pharm Unserer Zeit. 1996 Nov;25(6):334-5. Unique Identifier : AIDSLINE MED/97177894; Stipsits H; Bristol-Myers Squibb, Wien.
[Every year there are still 2000 more cases of HIV infection]: Pharm Unserer Zeit. 1996 Nov;25(6):339-40. Unique Identifier : AIDSLINE MED/97177895
Women's health. Sexually transmitted diseases.: Prim Care. 1997 Mar;24(1):179-93. Unique Identifier : AIDSLINE MED/97169322; Miller KE; Department of Family Medicine, Chattanooga Unit, University of; Tennessee College of Medicine, Chattanooga, Tennessee 37403, USA.; When providing health care for women, one of the more common problems facing the primary care physician is sexually transmitted diseases (STDs). It is important to be able to develop an accurate diagnosis and appropriate treatment plan for STDs to reduce the potential long-term sequelae of these infections. It is also
[Management of HIV infected patients. Report of recommendations]: Rev Pneumol Clin. 1996;52(5):277-360. Unique Identifier : AIDSLINE MED/97219536
Cytokine mRNA expression in lung tissue from toxic oil syndrome patients: a TH2 immunological mechanism.: Toxicology. 1997 Mar 14;118(1):61-70. Unique Identifier : AIDSLINE MED/97228594; del Pozo V; de Andres B; Gallardo S; Cardaba B; de Arruda-Chaves E; Cortegano MI; Jurado A; Palomino P; Oliva H; Aguilera B; Posada M; Lahoz C; Immunology Department, Fundacion Jimenez Diaz, Universidad Autonoma de; Madrid, Spain.<