Pancreatic ductal changes in HIV-infected patients. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Pancreatic ductal changes in HIV-infected patients.

Gastrointest Endosc. 1997 Jan;45(1):59-63. Unique Identifier : AIDSLINE MED/97165410
Barthet M; Chauveau E; Bonnet E; Petit N; Bernard JP; Gastaut JA; Sahel J; Department of Gastroenterology and Hepatology, Hopital; Sainte-Marguerite, Marseille, France.

Abstract: BACKGROUND: AIDS-related sclerosing cholangitis occurs in patients with advanced immunodeficiency, but ductal pancreatic alterations have not been evaluated in large series. METHODS: Twenty-nine consecutive patients with a mean age of 33 years underwent ERCP for biliary work-up. Complete pancreatography was obtained in 28 patients. Serum levels of amylase were increased in 17 patients prior to ERCP. The mean duration of HIV infection was 6.1 years (range 3 to 10 years). RESULTS: Fifteen patients 53.6%) had pancreatographic changes classified according to the Cambridge classification (stage 1, 4 cases; stage 2, 7 cases; stage 3, 4 cases). Dilatations, irregularities, short stenoses of the main pancreatic duct, and irregularities of side branches were the most frequent abnormalities. Fourteen of these 15 patients (93.3%) had cholangitis and a CD4 cell count of less than 60 per cubic millimeter. Risk factors for pancreatic damage were similar in patients with and without pancreatographic changes. Opportunistic infection occurred in 14 of 15 patients with pancreatographic changes (candida, cytomegalovirus, cryptosporidia, microsporidia, and mycobacteria). CONCLUSION: Abnormal pancreatographies were found in about half of the HIV-infected patients who underwent ERCP. The pancreatographic features were suggestive of chronic pancreatitis and were closely related to the presence of AIDS-related sclerosing cholangitis.
Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS *Pancreatic Diseases/ETIOLOGY *Pancreatic Ducts/PATHOLOGYKWDacquiredimmunodeficiencysyndrome/complicationsKWDpancreaticdiseases/etiologyKWDpancreaticducts/pathology
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M9772085

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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