1997

Combinatorial libraries, epitope structure and the prediction of protein conformations.: Immunol Today. 1997 Mar;18(3):108-10. Unique Identifier : AIDSLINE MED/97233778; Gershoni JM; Stern B; Denisova G; Dept of Cell Research and Immunology, Tel Aviv University, Israel.; gershoni@post.tau.ac.il
Aqueous solution structure of a hybrid lentiviral Tat peptide and a model of its interaction with HIV-1 TAR RNA.: J Biomol Struct Dyn. 1996 Feb;13(4):649-60. Unique Identifier : AIDSLINE MED/97063017; Mujeeb A; Parslow TG; Yuan YC; James TL; Department of Pharmaceutical Chemistry, University of California, San; Francisco 94143-0446, USA.; Human immunodeficiency virus, type 1, (HIV-1) encodes a transactivating regulatory protein, called Tat, which is required for efficient transcription of the viral genome. Tat acts by binding to a specific RNA stem-loop element, called TAR, on nascent viral transcripts. The specificity of binding is principally determi
The treatment of antiretroviral-naive subjects with the 3TC/zidovudine combination: a review of North American (NUCA 3001) and European (NUCB 3001) trials.: AIDS. 1996 Dec;10 Suppl 5:S11-9. Unique Identifier : AIDSLINE MED/97182351; Eron JJ Jr; University of North Carolina, Chapel Hill 27599-7030, USA.; OBJECTIVE: The compound (-)-2 ,3 -dideoxy-3 -thiacytidine ( 3TC , lamivudine) is a nucleoside analogue with potent in vitro antiretroviral activity, synergy with zidovudine, activity against zidovudine-resistant isolates and minimal cytotoxicity. In ear
The role of immunologic and viral markers in predicting clinical outcome in HIV infection.: AIDS. 1996 Dec;10 Suppl 5:S21-5. Unique Identifier : AIDSLINE MED/97182352; Graham NM; Johns Hopkins University, Baltimore, Maryland, USA.; OBJECTIVE: In an ideal world, one clinical marker would explain all the variance in a disease system. In reality, however, this is rarely the case and HIV disease is no exception. This review considers several specific markers that have demonstrated some use in clinical trials and/or epidemiologic studies of antiretro
Clinical significance of drug resistance in HIV-1 infection.: AIDS. 1996 Dec;10 Suppl 5:S27-31. Unique Identifier : AIDSLINE MED/97182353; Kuritzkes DR; Division of Infectious Diseases, University of Colorado Health; Sciences Center, Denver 80262, USA.; OVERVIEW: The limited duration of clinical benefit from nucleoside analogue therapy for HIV-1 infection may be explained, in part, by the emergence of virus isolates resistant to the drugs used. Additional reasons may include the presence of syncytium-inducing variants of HIV-1, progressive increase in viral load and
Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase.: AIDS. 1996 Dec;10 Suppl 5:S3-10. Unique Identifier : AIDSLINE MED/97182350; Wainberg MA; Hsu M; Gu Z; Borkow G; Parniak MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.; OBJECTIVE: To measure the extent of HIV resistance to 2 ,3 -dideoxy-3 -thiacytidine ( 3TC , lamivudine) within the context of monotherapy and to assess the presence of the M184V substitution in the case of 3TC-resistant viruses. Whether the success of 3
[Diagnosis and treatment of facial palsy]: Neurologia. 1997 Jan;12(1):23-30. Unique Identifier : AIDSLINE MED/97222725; Noya M; Pardo J; Servicio de Neurologia, Hospital General de Galicia-Clinico; Universitario, Santiago de Compostela.; The topographic diagnosis of facial nerve lesions is based on the symptoms that accompany paralysis, allowing lesions to be located in the protuberance, pontocerebellar angle, facial channel or trajectory distal to the stylomastoid foramen. Most cases of peripheral facial palsy have no apparent cause (idiopathic, or B
Using cost-effectiveness/cost-benefit analysis to allocate health resources: a level playing field for prevention?: Am J Prev Med. 1997 Jan-Feb;13(1):18-25. Unique Identifier : AIDSLINE MED/97189066; Phillips KA; Hotlgrave DR; Department of General Internal Medicine Institute for Health Policy; Studies, School of Medicine, University of California, San Francisco,; USA.; INTRODUCTION: Prevention is being promoted as a means to improve health status and to save health care costs. Economic evaluations of prevention (i.e., cost-effectiveness and cost-benefit analyses) indicate that some prevention activities, like many treatments, do not save money, although many are relatively cost-effe
[Clinical and ultrastructural evaluation of nasal mucociliary function in HIV-positive patients. Preliminary investigation]: Acta Otorrinolaringol Esp. 1997 Jan-Feb;48(1):27-30. Unique Identifier : AIDSLINE MED/97245402; Armengot M; Climent B; Carda C; Ortega E; Basterra J; Servicio de ORL, Facultad de Medicina, Hospital General Universitario; de Valencia.; Nasal mucociliary transport was studied in 33 HIV-positive patients with different stages of infection. Ciliary ultrastructure was studied in 8 of these cases. At the time of study, 24 patients had respiratory infections. Disturbances in mucociliary transport were found in 25 cases. In 6 of the 8 studies of ciliary ul
The costs and effectiveness of surveillance of communicable disease: a case study of HIV and AIDS in England and Wales.: J Public Health Med. 1996 Dec;18(4):415-22. Unique Identifier : AIDSLINE MED/97176227; Morris S; Gray A; Noone A; Wiseman M; Jathanna S; City University, London, UK.; BACKGROUND: In England and Wales, surveillance of communicable disease is carried out and co-ordinated by the Public Health Laboratory Service (PHLS). The surveillance of HIV infection and AIDS is undertaken by the PHLS AIDS Centre at the Communicable Disease Surveillance Centre (CDSC). Epidemiological data derived fr
The use and cost of hospital services by London AIDS patients with different AIDS defining conditions.: J Public Health Med. 1996 Dec;18(4):457-64. Unique Identifier : AIDSLINE MED/97176233; Beck EJ; Kupek EJ; Wadsworth J; Miller DL; Pinching AJ; Harris JR; Department of Epidemiology and Public Health, Imperial College School; of Medicine at St Mary's, London.; BACKGROUND: Contracting for HIV service provision is now an established part of the National Health Service commissioning process. AIDS is a heterogeneous condition, comprising various opportunistic illnesses which require different services and which have different resource implications. This study describes the use
Hematologic complications of HIV infection.: Oncology (Huntingt). 1996 May;10(5):671-80. Unique Identifier : AIDSLINE MED/96336707; Hambleton J; Department of Medicine, University of California, San Francisco, USA.; Hematologic complications of HIV disease are commonly encountered by physicians and other health-care workers caring for patients infected with this virus. Ineffective hematopoiesis, infiltrative diseases of the bone marrow, nutritional deficiencies, peripheral destruction of blood cells secondary to splenomegaly or i
AIDS activists meet to establish community-based standards for life insurance settlements [news]: Oncology (Huntingt). 1996 May;10(5):712. Unique Identifier : AIDSLINE MED/96336710
Role of thymic selection in the development of thymic lymphomas in TCR transgenic mice.: Int Immunol. 1997 Jan;9(1):127-38. Unique Identifier : AIDSLINE MED/97196865; Strzadala L; Miazek A; Matuszyk J; Kisielow P; Institute of Immunology and Experimental Therapy, Polish Academy of; Sciences, Wroclaw, Poland.; To investigate the role of antigen receptor-mediated interactions in lymphomagenesis we have analyzed the influence of alpha beta TCR-mediated selection on the development of spontaneous thymic lymphomas, which appear with a high (up to 50%) frequency in mice expressing a transgenic TCR specific for the male antigen (
The xid mutation plays an important role in delayed development of murine acquired immunodeficiency syndrome.: Int Immunol. 1997 Jan;9(1):139-46. Unique Identifier : AIDSLINE MED/97196866; Numata F; Hitoshi Y; Uehara S; Takatsu K; Department of Immunology, University of Tokyo, Japan.; Infection of C57BL/6 mice with LP-BM5 murine leukemia virus MuLV) leads to the development of murine acquired immunodeficiency syndrome (MAIDS) characterized by abnormal lymphoproliferation, hypergammaglobulinemia and severe immunodeficiency. Progression of MAIDS is delayed in X chromosome-linked immunodeficient (XID)
Modulation of proliferation and lymphokine secretion of murine CD4+ T cells and cloned Th1 cells by proteins of the extracellular matrix.: Int Immunol. 1997 Jan;9(1):147-59. Unique Identifier : AIDSLINE MED/97196867; Tschoetschel U; Schwing J; Frosch S; Schmitt E; Schuppan D; Reske-Kunz AB; Department of Dermatology, Johannes Gutenberg-University, Mainz,; Germany.; In this study we investigated the co-stimulatory signaling capacity of diverse proteins of the extracellular matrix (ECM) for murine resting CD4+ T cells and Th1 clone cells, activated by immobilized anti-CD3 mAb. ECM proteins used in various concentrations had no effect on
HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck.: Int Immunol. 1997 Jan;9(1):53-64. Unique Identifier : AIDSLINE MED/97196858; Morio T; Chatila T; Geha RS; Division of Immunology, Children's Hospital, Boston, MA 02115, USA.; HIV major glycoprotein gp120 interacts with CD4 molecules and perturbs signaling through the TCR-CD3 complex. We examined the effects of gp120 on TCR-CD3-induced phosphorylation and activation of the src-type protein tyrosine kinases (PTK), fyn and lck. gp120 caused minimal changes in lck phosphorylation or lck enzyma
Lack of Th1 or Th2 polarization of CD4+ T cell response induced by particulate antigen targeted to phagocytic cells.: Int Immunol. 1997 Jan;9(1):91-103. Unique Identifier : AIDSLINE MED/97196862; Sedlik C; Deriaud E; Leclerc C; Unite de Biologie ces Regulations Immunitaires, Institut Pasteur,; Paris, France.; Several factors are involved in the selective activation of Th1 or Th2 subset of CD4+ T cells, such as the type of antigen-presenting cells, the dose of antigen, the route of immunization, etc. To analyze the influence of accessory cells on Th1/Th2 cell differentiation, we used a particulate antigen prepared by covale
Dissection of the proposed base triple in human immunodeficiency virus TAR RNA indicates the importance of the Hoogsteen interaction.: Biochemistry. 1997 Mar 25;36(12):3491-5. Unique Identifier : AIDSLINE MED/97238548; Tao J; Chen L; Frankel AD; Department of Biochemistry and Biophysics, University of California,; San Francisco 94143-0448, USA.; A single arginine residue within the RNA-binding domain of the human immunodeficiency virus Tat protein makes a critical sequence-specific contact to TAR RNA. Arginine as the free amino acid also binds specifically to TAR and induces a change in RNA conformation similar to that induced by Tat peptides. NMR and biochem
Chemical cross-linking of the human immunodeficiency virus type 1 Tat protein to synthetic models of the RNA recognition sequence TAR containing site-specific trisubstituted pyrophosphate analogues.: Biochemistry. 1997 Mar 25;36(12):3496-505. Unique Identifier : AIDSLINE MED/97238549; Naryshkin NA; Farrow MA; Ivanovskaya MG; Oretskaya TS; Shabarova ZA; Gait MJ; Laboratory of Molecular Biology, Medical Research Council, Cambridge,; U.K.; A chemical ligation procedure has been developed for the synthesis of oligoribonucleotides carrying a trisubstituted pyrophosphate (tsp) linkage in place of a single phosphodiester. Good yields of tsp were obtained when a single 2 -deoxynucleoside 5 to the tsp was used in the ligation reaction. A tsp linkage was founa
Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin.: Biochemistry. 1997 Apr 1;36(13):3941-9. Unique Identifier : AIDSLINE MED/97246586; Szebeni A; Mehrotra B; Baumann A; Adam SA; Wingfield PT; Olson MO; Department of Biochemistry, University of Mississippi Medical Center,; Jackson 39216, USA.; Nucleolar phosphoprotein B23 is a putative ribosome assembly factor with a relatively high affinity for peptides containing sequences of nuclear localization signals (NLSs) of the SV40 T-antigen type [Szebeni, A., Herrera, J. E., & Olson, O. J. 1995) Biochemistry 34, 8037-8042]. The effects of protein B23 on nuclea
Psychiatric manifestations and magnetic resonance imaging in HIV-negative neurosyphilis.: Biol Psychiatry. 1997 Feb 15;41(4):467-73. Unique Identifier : AIDSLINE MED/97187088; Russouw HG; Roberts MC; Emsley RA; Truter R; Department of Psychiatry, University of Stellenbosch, South Africa.; Neurosyphilis can mimic virtually any psychiatric disorder. Since there are no studies measuring the relationship between its psychiatric manifestations and neuroradiological findings, we performed magnetic resonance imaging (MRI) on 20 newly diagnosed patients with neurosyphi
Neurophysiological changes associated with psychiatric symptoms in HIV-infected individuals without AIDS.: Biol Psychiatry. 1997 Feb 15;41(4):474-87. Unique Identifier : AIDSLINE MED/97187089; Baldeweg T; Catalan J; Pugh K; Gruzelier J; Lovett E; Scurlock H; Burgess A; Riccio M; Hawkins D; Academic Department of Psychiatry, Charing Cross & Westminster Medical; School, London, United Kingdom.; HIV-1 infection may be complicated by a number of psychopathological conditions. While organic mental disorders, such as HIV-related psychosis and dementia , are late manifestations, mood disorders may occur during both asymptomatic and symptomatic stages of infection. The possible
Elevated frontal lobe cytosolic choline levels in minimal or mild AIDS dementia complex patients: a proton magnetic resonance spectroscopy study.: Biol Psychiatry. 1997 Feb 15;41(4):500-2. Unique Identifier : AIDSLINE MED/97187093; English CD; Kaufman MJ; Worth JL; Babb SM; Drebing CE; Navia BA; Renshaw PF; Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02178,; USA.
[Percutaneous liver biopsy: comparative study on the efficacy of and tolerance to the automatic tru-cut technique]: An Med Interna. 1996 Sep;13(9):419-22. Unique Identifier : AIDSLINE MED/97122084; Garcia Ordonez MA; Antunez Galvez JM; Aguilar Heredia Y; Colmenero Castillo JD; Causse Prados M; Juarez Fernandez C; Servicio de Medicina Interna, Hospital Regional Carlos Haya, Malaga.; Percutaneous liver biopsy (PLB) is an useful tool in accurately diagnosing difuse hepatopathy and systemic procedures like fever of unknown origin (FUO) and human immunodeficiency virus infection. Present job compares two different PLB procedures, automatic tru-cut needle versus Menghini needle. We have achieved 143 P
[Report of a case of T-cell peripheral lymphoblastic lymphoma in an HIV patient]: An Med Interna. 1996 Sep;13(9):443-6. Unique Identifier : AIDSLINE MED/97122090; Garcia de la Llana F; Mota Vargas R; Rovira Farre I; Pazlasso S; Alejo Pedrero M; Ambrojo P; Unidad Enfermedades Infecciosas, Hospital Regional Universitario; Infanta Cristina, Badajoz.; T-cell lymphomas in human immunodeficiency virus infections are rare, first case have being described in 1987, by Presant. Our purpose is to report the first T-cell Lymphoma case without epidermotropism in an HIV patient in Extremadura, and pioneer in Spain . Clinic extensive and his
Viral lesions of the mouth in HIV-infected patients.: Dermatology. 1997;194(1):1-7. Unique Identifier : AIDSLINE MED/97183822; Itin PH; Lautenschlager S; Department of Dermatology, University of Basel, Switzerland.; Viral lesions of the mouth in patients with HIV infection are common and these diseases any be a marker for HIV and disease progression. We review the spectrum of oral viral manifestations and discuss treatment modalities. The most common Epstein-Barr virus (EBV)-induced disorder in HIV-infected patients is oral hairy
Lichen amyloidosis presenting as a papular pruritus syndrome in a human-immunodeficiency-virus-infected man.: Dermatology. 1997;194(1):62-4. Unique Identifier : AIDSLINE MED/97183835; Goller MM; Cohen PR; Duvic M; Department of Dermatology, University of Texas-Houston Medical School; 77030, USA.; A human-immunodeficiency-virus (HIV)-positive man presented with pruritic erythematous and flesh-colored papules on his arms and trunk of 1 year s duration. The lesions had previously been treated with oral ketoconazole and topical emollients with no improvement. Microscopic evaluation of lesional skin from his left f
Remission of localized cutaneous leishmaniasis in a HIV-positive patient using systemic terbinafine [letter]: Dermatology. 1997;194(1):85-6. Unique Identifier : AIDSLINE MED/97183842; Gonzalez-Ruperez J; Javaloyas de Morlius M; Moreno Carazo A
Demonstration of herpes virus 8 in a lymphangioma-like Kaposi's sarcoma occurring in a non-immunosuppressed patient [letter]: Dermatology. 1997;194(1):90-1. Unique Identifier : AIDSLINE MED/97183846; Noel JC; de Thier F; de Dobbeleer G; Heenen M
[The clinico-epidemiological aspects of a case of Cryptococcus neoformans meningoencephalitis]: Bacteriol Virusol Parazitol Epidemiol. 1993 Jan-Jun;38(1-2):36-8. Unique Identifier : AIDSLINE MED/97271806; Rugina S; Rugina C; Zalupca L; Dinisov M; Spitalul Municipal Constanta.
Dendritic cells: from ignored cells to major players in T-cell-mediated immunity.: Int Arch Allergy Immunol. 1997 Apr;112(4):317-22. Unique Identifier : AIDSLINE MED/97258591; Schuler G; Thurner B; Romani N; Department of Dermatology, University of Erlangen-Nurnberg, Erlangen,; Germany. schuler@derma.med.uni-erlangen.de; Dendritic cells form a system of leukocytes specialized to stimulate resting T cells in vivo. Dendritic cells are crucial for the initiation of primary immune responses of both helper and cytotoxic T lymphocytes, and thus act as nature s adjuvant . The manifold specializations underlying this in vivo immunostimulator
South African research into AIDS "cure" severely criticised [news]: BMJ. 1997 Mar 15;314(7083):771. Unique Identifier : AIDSLINE MED/97236080; Sidley P
Doctor who refused HIV test is struck off register [news] [see comments]: BMJ. 1997 Mar 22;314(7084):847. Unique Identifier : AIDSLINE MED/97246944; Dyer C
An ethical dilemma. Availability of antiretroviral therapy after clinical trials with HIV infected patients are ended [see comments]: BMJ. 1997 Mar 22;314(7084):887-8. Unique Identifier : AIDSLINE MED/97246959; Cleaton-Jones PE; Committee for Research on Human Subjects (Medical), University of the; Witwaterstand, Johannesburg, South Africa.
Strident, but essential: the voices of people with AIDS [comment]: BMJ. 1997 Mar 22;314(7084):888-9. Unique Identifier : AIDSLINE MED/97246960; Busse P; NAPWA South Africa, Western Cape.
Drug companies have a duty to continue treatment [comment]: BMJ. 1997 Mar 22;314(7084):889. Unique Identifier : AIDSLINE MED/97246961; Emery S; Cooper DA; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, Sydney, Australia.
A case for goodwill [comment]: BMJ. 1997 Mar 22;314(7084):890. Unique Identifier : AIDSLINE MED/97246962; McLean GR; Department of Philosophy, University of the Witwaterstand,; Johannesburg, South Africa.
A partnership to resolve the conundrum [comment]: BMJ. 1997 Mar 22;314(7084):890-1. Unique Identifier : AIDSLINE MED/97246963; King P; Roche Products, Wetwyn Garden City.
Management of needlestick injuries would be easier if consent for donor" testing was not necessary [letter; comment]: BMJ. 1997 Mar 22;314(7084):905. Unique Identifier : AIDSLINE MED/97246982; Walker E; Wright P
Trust me--I'm a doctor [see comments]: BMJ. 1997 Mar 22;314(7084):910. Unique Identifier : AIDSLINE MED/97246984; Craft N
Discrimination, informed consent, and the HIV infected clinician [editorial]: BMJ. 1997 Mar 29;314(7085):915-6. Unique Identifier : AIDSLINE MED/97253872; Bayer R
Intestinal absorption and first-pass elimination of 2', 3'-dideoxynucleosides following oral administration in rats.: Biol Pharm Bull. 1996 Apr;19(4):599-603. Unique Identifier : AIDSLINE MED/97014131; Hasegawa T; Juni K; Saneyoshi M; Kawaguchi T; Faculty of Pharmaceutical Sciences, Josai University, Japan.; Intestinal absorption and first-pass elimination of 2 ,3 -dideoxynucleosides (ddNs), including 3 -azido-3 -deoxythymidine ( AZT ), 2 ,3 -dideoxyinosine (DDI) and 2 ,3 -didehydro-3 -deoxythymidine (D4T), following oral administration was investigated in
Tax-independent stimulation of human T-cell leukemia virus type-I expression and differential effects on its infectivity by subtoxic and toxic doses of 3-methylcholanthrene.: Cell Mol Biol Res. 1995;41(5):377-85. Unique Identifier : AIDSLINE MED/97021424; Revazova T; Dombrovsky A; Lochelt M; Flugel RM; Aboud M; Department of Microbiology and Immunology, Ben Gurion University of; the Negev, Beer Sheva, Israel.; Using the human T-cell leukemia virus type I (HTLV-I) infected SLB-I T-cell line, we showed in this study that 5-d treatment with the maximal subtoxic 3-methylcholanthrene (3-MC) dose (0.25 microgram/ml), as well as with a 3-MC dose that inhibits 50% of the cell growth (5 micrograms/ml), profoundly increased the level
A probability-based approach for predicting HIV infection in a low prevalent population of injection drug users.: Ann Epidemiol. 1997 Jan;7(1):28-34. Unique Identifier : AIDSLINE MED/97186950; Cheng FK; Ford WL; Weber MD; Cheng SY; Kerndt PR; Los Angeles County Department of Health Services, HIV Epidemiology; Program, CA 90005, USA.; This article proposes a method for estimating HIV risk in low-HIV-prevalent populations. Allard s risk probability model was used to compute individual risk scores. Based on a sample of 3854 injection drug users (IDUs) who were confidentially tested for HIV at five methadone treatment clinics in Los Angeles County, th
The surgeon's database for AIDS: a collective review.: J Am Coll Surg. 1997 Apr;184(4):403-12. Unique Identifier : AIDSLINE MED/97255342; Flum DR; Wallack MK; Department of Surgery, St. Vincents Hospital and Medical Center, New; York, NY, USA.; BACKGROUND: The human immunodeficiency virus infection and acquired immunodeficiency syndrome have had a dramatic effect on the practice of surgery. Critical issues include quantifying the risk encountered by surgeons when operating on infected patients, the benefits of chemoprophylaxis after injury by a health care w
Resistance to HIV infection: the genes are only part of the solution.: Trends Microbiol. 1997 Jan;5(1):2-4. Unique Identifier : AIDSLINE MED/97177721; Clerici M; Clivio A; Shearer GM; Cattedra di Immunologia, Padiglione LITA, H.L. Sacco, Universita di; Milano, Italy.
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.: Structure. 1996 Jul 15;4(7):853-60. Unique Identifier : AIDSLINE MED/96434330; Hsiou Y; Ding J; Das K; Clark AD Jr; Hughes SH; Arnold E; Center for Advanced Biotechnology and Medicine (CABM), Piscataway, NJ,; USA.; BACKGROUND: HIV-1 reverse transcriptase (RT) is a major target for anti-HIV drugs. A considerable amount of information about the structure of RT is available, both unliganded and in complex with template-primer or non-nucleoside RT inhibitors (NNRTIs). But significant conformational differences in the p66 polymerase
Arterial homografts--a possible solution to an infective dilemma.: Cardiovasc Surg. 1996 Dec;4(6):796-800. Unique Identifier : AIDSLINE MED/97165252; Wagstaff SA; Grigg MJ; Vascular Surgical Unit, Alfred Hospital, Camberwell, Victoria,; Australia.; Seven patients with infected arterial conduits (six with prosthetic bypass grafts and one autogenous vein anastomosis) with ten limbs at risk (three patients with bilateral groin infection) are reported. The most common site for infection was the groin and the most frequent organism cultured was Staphylococcus aureus.
Broad plan essential for tuberculosis elimination, say researchers [news]: Am J Health Syst Pharm. 1997 Feb 15;54(4):361, 365. Unique Identifier : AIDSLINE MED/97196443
Status and future of vaccines for adults.: Am J Health Syst Pharm. 1997 Feb 15;54(4):379-87. Unique Identifier : AIDSLINE MED/97196447; Grabenstein JD; U.S. Army Medical Department, School of Pharmacy, University of North; Carolina, Chapel Hill 27599-7360, USA. jgrabens@sph.unc.edu; The current status and future prospects of vaccines for adults are discussed. For every child in America who dies of a vaccine-preventable disease, about 400 adults die of such a disease. Evidence of the merit of influenza vaccination continues to accumulate, yet
An erythematous rash, diarrhea, failure to thrive, and lymphadenopathy in a 3-month-old girl [clinical conference]: Ann Allergy Asthma Immunol. 1997 Mar;78(3):253-8. Unique Identifier : AIDSLINE MED/97242092; Sicherer SH; Lederman HM; Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland,; USA.
Aeroallergen-specific IgE changes in individuals with rapid human immunodeficiency virus disease progression.: Ann Allergy Asthma Immunol. 1997 Mar;78(3):301-6. Unique Identifier : AIDSLINE MED/97242101; Goetz DW; Webb EL Jr; Whisman BA; Freeman TM; Allergy-Immunology Department, Wilford Hall Medical Center, Lackland; AFB, Texas, USA.; BACKGROUND: Progression of human immunodeficiency virus type 1 HIV-1) infection to the acquired immunodeficiency syndrome AIDS) is associated with elevated total IgE; however, previous cross-sectional studies have differed in their assessment of concurrent changes in allergic disease prevalence. OBJECTIVE: Assessment
Retinal findings and characteristics in AIDS patients with systemic Mycobacterium avium-intracellulare complex and toxoplasmic encephalitis.: Ophthalmic Surg Lasers. 1997 Jan;28(1):50-4. Unique Identifier : AIDSLINE MED/97183166; Arevalo JF; Quiceno JI; Garcia RF; McCutchan JA; Munguia D; Nelson JA; Freeman WR; Department of Ophthalmology, Shiley Eye Center, La Jolia, CA; 92093-0946, USA.; BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the incidence and characteristics of retinal and choroidal manifestations of toxoplasmosis and/or Mycobacterium avium-intracellulare complex (MAC) in patients with acquired immunodeficiency syndrome (AIDS). PATIENTS AND METHODS: The authors analyzed t
Respiratory isolation of patients with suspected pulmonary tuberculosis in an inner-city hospital.: Acad Emerg Med. 1997 Feb;4(2):138-41. Unique Identifier : AIDSLINE MED/97196430; Gaeta TJ; Webheh W; Yazji M; Ahmed J; Yap W; Department of Emergency Medicine, St. Barnabas Hospital, Bronx, NY; 10457-2594, USA. tgaeta@mem.po.com; OBJECTIVE: To identify clinical factors that predict which patients presenting to the ED with pneumonia will require respiratory isolation for suspected tuberculosis and to evaluate a protocol for rapid identification of patients at risk for pulmonary tuberculosis (PTB). METHODS: To identify potential clinical indicat
Lymphogranuloma venereum: a case report in an Italian traveller.: New Microbiol. 1997 Jan;20(1):83-6. Unique Identifier : AIDSLINE MED/97189437; Monno R; Pastore G; Lamargese V; Leone E; Valenza MA; Angarano G; Institute of Medical Microbiology, University of Bari, Italy.; A 38-year-old man with a recent history of travel in India and unprotected sexual intercourse with Indian women, was admitted with painful enlarged lymphnodes predominantly in the right inguinal area. Diagnosis of lymphogranuloma venereum was made by means of a positive immunofluore
Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk.: Mol Med. 1997 Jan;3(1):23-36. Unique Identifier : AIDSLINE MED/97206137; Zimmerman PA; Buckler-White A; Alkhatib G; Spalding T; Kubofcik J; Combadiere C; Weissman D; Cohen O; Rubbert A; Lam G; Vaccarezza M; Kennedy PE; Kumaraswami V; Giorgi JV; Detels R; Hunter J; Chopek M; Berger EA; Fauci AS; Nutman TB; Murphy PM; Laboratory of Parasitic Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-0425, USA.; BACKGROUND: CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5 allele (designated here as CCR5-2) was identified that confers resistance to HIV-1 infection in homozygotes and slows the rate of progression to AIDS
Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.: Mol Med. 1997 Jan;3(1):60-71. Unique Identifier : AIDSLINE MED/97206140; Wallace M; Scharko AM; Pauza CD; Fisch P; Imaoka K; Kawabata S; Fujihashi K; Kiyono H; Tanaka Y; Bloom BR; Malkovsky M; Department of Medical Microbiology and Immunology, University of; Wisconsin Medical School, Madison 53706, USA.; BACKGROUND: Antiviral cellular immune responses may influence immunological homeostasis in HIV-infected persons. Recent data indicate that V gamma 9/V delta 2 T lymphocytes display potent cytotoxic activities against human cells infected with certain viruses including HIV. Understanding the role of gamma delta T cells
HIV-1 antibody--debris or virion? [letter] [see comments] [published erratum appears in Nat Med 1997 Jun;3(6):591]: Nat Med. 1997 Apr;3(4):366-7. Unique Identifier : AIDSLINE MED/97249254; Parren WH; Burton DR; Sattentau QJ
HIV CCR5 resistance incomplete [news]: Nat Med. 1997 Apr;3(4):372-3. Unique Identifier : AIDSLINE MED/97249257; Smith O
HIV accessory proteins as therapeutic targets.: Nat Med. 1997 Apr;3(4):389-94. Unique Identifier : AIDSLINE MED/97249266; Miller RH; Sarver N; Targeted Interventions Branch, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-7620, USA.
Unconventional structure of tRNA(Lys)SUU anticodon explains tRNA's role in bacterial and mammalian ribosomal frameshifting and primer selection by HIV-1.: RNA. 1997 Apr;3(4):420-8. Unique Identifier : AIDSLINE MED/97240388; Agris PF; Guenther R; Ingram PC; Basti MM; Stuart JW; Sochacka E; Malkiewicz A; Department of Biochemistry, North Carolina State University, Raleigh,; North Carolina 27695, USA. agris@bchserver.bch.ncsu.edu; Transfer RNA(Lys)SUU, with a 5-modified-2-thiouridine at wobble position 34, facilitates -1 frameshifts for correct translation of the Escherichia coli DNA polymerase gamma subunit and retroviral polymerases. Peptidyl-tRNA(Lys)SUU prematurely terminates translation more often than other tRNAs. In order to determine if
Living with needlestick injuries.: J Can Dent Assoc. 1997 Apr;63(4):283-6. Unique Identifier : AIDSLINE MED/97270829; David HT; David YM; Faculty of Dentistry, University of British Columbia.; Exposure to contaminated sharp objects is one of the inherent hazards of working in a clinical setting. Today, primarily due to concerns about possible HIV infection, a terror-factor strikes mortal fear, whether imagined or real, in the heart of individuals who suffer a subcutaneous sharp object injury. The psycholo
An atlas of HIV-associated oral lesions: a new classification and diagnostic criteria.: J Can Dent Assoc. 1997 Apr;63(4):288-9, 292-4. Unique Identifier : AIDSLINE MED/97270830; Wiebe CB; Epstein JB; Department of Clinical Dental Sciences, Faculty of Dentistry,; University of British Columbia, Vancouver.; Many oral lesions are strongly associated with HIV infection. Along with the HIV-infected individual s T helper cell count (CD4 cell count), they indicate the severity of immune suppression. It is important for dental professionals to recognize these lesions early, as it alerts patients to their HIV status, and allows
Tuberculosis in Shelby County and Tennessee correctional facilities.: Tenn Med. 1997 Apr;90(4):138-40. Unique Identifier : AIDSLINE MED/97243246; Fountain FF Jr
Human immunodeficiency virus in women: mucocutaneous manifestations.: Clin Dermatol. 1997 Jan-Feb;15(1):93-111. Unique Identifier : AIDSLINE MED/97187206; Wright SW; Johnson RA; Division of Dermatology, Harvard Medical School, Deaconess Hospital,; Boston, MA 02215, USA.
Sporadic bovine leukosis associated with ataxia and tibiotarsal joint swelling: a case report.: Can Vet J. 1994 Dec;35(12):777-9. Unique Identifier : AIDSLINE MED/97271822; Oliver-Espinosa O; Physick-Sheard PW; Wollenberg GK; Taylor J; Department of Clinical Studies, Ontario Veterinary College, University; of Guelph.
Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor.: Cancer Res. 1997 Apr 15;57(8):1447-51. Unique Identifier : AIDSLINE MED/97262030; Goldman CK; Rogers BE; Douglas JT; Sosnowski BA; Ying W; Siegal GP; Baird A; Campain JA; Curiel DT; Gene Therapy Program, University of Alabama at Birmingham, 35294, USA.; Kaposi s sarcoma (KS) is a major AIDS-related malignancy associated with significant morbidity and mortality. Current chemotherapeutic regimens are associated with a dismal prognosis. In an effort to develop a new approach to KS treatment, we devised a gene therapy-based adenovirus retargeting schema that redirects th
Laparoscopic approach to interstitial pregnancy.: J Am Assoc Gynecol Laparosc. 1996 May;3(3):439-41. Unique Identifier : AIDSLINE MED/97238374; Woodland MB; DePasquale SE; Molinari JA; Sagullo CC; Pennsylvania Hospital, Department of Obstetrics and Gynecology, 8th; and Spruce Streets, Philadelphia, PA 19107, USA.; A 23-year-old woman was diagnosed with a 5-cm interstitial pregnancy by transvaginal ultrasound. In addition, she was positive for the human immunodeficiency virus. She underwent laparoscopic cornual excision of the ectopic gestation and was discharged home the next day.
Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125.: Fold Des. 1996;1(2):157-65. Unique Identifier : AIDSLINE MED/97233153; Campbell AP; Sykes BD; Norrby E; Assa-Munt N; Dyson HJ; Department of Molecular Biology, Scripps Research Institute, La Jolla,; California 92037, USA.; BACKGROUND: The conformational preferences of a number of peptides with sequences related to the envelope glycoproteins of HIV-1 have been investigated in the past few years. Similar studies have not been made for HIV-2, which is a distinct virus with similar physiological effects to those of HIV-1. The discovery of c
Flow-cytometric assessment of in vivo cytokine-producing monocytes in HIV-infected patients.: Clin Immunol Immunopathol. 1997 Apr;83(1):60-7. Unique Identifier : AIDSLINE MED/97242249; Estcourt C; Rousseau Y; Sadeghi HM; Thieblemont N; Carreno MP; Weiss L; Haeffner-Cavaillon N; INSERM U430, Hopital Broussais, Paris, France.; We have used two-color flow cytometry to study in vivo monocytic cytokine production at the single-cell level in HIV-infected patients. We demonstrated the presence of intracellular IL-1 alpha, IL-1 beta, IL-1ra, and TNF alpha in circulating CD14+ monocytes from HIV-infected patients. The specificity of intracellular
Pathologic correlations between ocular and cerebral lesions in 36 AIDS patients.: Clin Neuropathol. 1997 Jan-Feb;16(1):45-8. Unique Identifier : AIDSLINE MED/97172311; Leger F; Vital C; Vital A; Morlat P; Ragnaud JM; Dupon M; Neuropathology Department, (Pellegrin Hospital), Bordeaux, France.; The eyes and brain have rarely been studied simultaneously in AIDS patients. We have examined both the eyes and brain of 36 patients autopsied these past 3 years. Ten cases had concomitant involvement of eyes and brain by the same pathology: cryptococcus neoformans in 1, aspergillus in another,
In vitro susceptibility of 115 isolates of Candida to amphotericin B, fluconazole and itraconazole.: Drugs Exp Clin Res. 1996;22(6):301-7. Unique Identifier : AIDSLINE MED/97187303; Mallie M; Bastide JM; Immunology-Parasitology Laboratory, Faculty of Pharmacy, Montpellier,; France.; Opportunistic fungal infections are an increasingly important cause of morbidity and mortality particularly due to Candida species (1). There is also an increase of candidosis especially ascribed to acquired or induced immunodeficiency syndromes or in the event of long-term antibiotic, immuno-suppressor or cytotoxic t
Changes in HIV-related behaviors among heterosexual alcoholics following addiction treatment.: Drug Alcohol Depend. 1997 Jan 10;44(1):47-55. Unique Identifier : AIDSLINE MED/97183860; Avins AL; Lindan CP; Woods WJ; Hudes ES; Boscarino JA; Kay J; Clark W; Hulley SB; Department of Epidemiology and Biostatistics, University of; California, San Francisco, USA.; In order to measure changes in HIV-related behaviors among heterosexual alcoholics following treatment, we conducted a prospective cohort study of 700 self-identified alcoholics recruited from five public alcohol treatment centers, all of which included HIV risk-reduction counseling. Respondents underwent an HIV antib
Effects of HIV seropositivity and drug abuse on cognitive function.: Eur Neurol. 1997;37(1):48-52. Unique Identifier : AIDSLINE MED/97170729; Grassi MP; Perin C; Clerici F; Zocchetti C; Borella M; Cargnel A; Mangoni A; Department of Neurology, L. Sacco Hospital, Milan, Italy.; Fifty-eight HIV-positive drug abusers and 22 HIV-positive nondrug abusers at stages II-III and IV of the Centers for Disease Control classification were evaluated neuropsychologically. The study confirmed previous findings that drug abuse has a negative influence on cognitive function. It also emerges that seropositiv
Multiple sites of post-activation CD8+ T cell disposal.: Eur J Immunol. 1997 Mar;27(3):577-83. Unique Identifier : AIDSLINE MED/97234521; Wack A; Corbella P; Harker N; Crispe IN; Kioussis D; Division of Molecular Immunology, National Institute for Medical; Research, London, GB.; Antigen-triggered activation of T cells leads to a sequence of differentiation steps including up-regulation of activation markers, blast formation, proliferation, delivery of effector functions, and ultimately apoptosis. It is still controversial in which anatomical site activation-induced apoptosis and elimination o
B7-1-dependent co-stimulation results in qualitatively and quantitatively different responses by CD4+ and CD8+ T cells.: Eur J Immunol. 1997 Mar;27(3):598-608. Unique Identifier : AIDSLINE MED/97234524; Deeths MJ; Mescher MF; The Department of Laboratory Medicine and Pathology, University of; Minnesota, Minneapolis 55455, USA.; To characterize better the co-stimulatory activity of native B7-1 in the absence of other receptor/ligand interactions that might contribute to the response, B7-1 was purified by monoclonal antibody (mAb) affinity chromatography. Immobilization of purified B7-1 with anti-T cell receptor (TCR) mAb on cell-sized latex m
Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.: Eur J Immunol. 1997 Mar;27(3):633-40. Unique Identifier : AIDSLINE MED/97234528; Webb LM; Foxwell BM; Feldmann M; Kennedy Institute of Rheumatology, London, GB.; Interleukin (IL)-4 is considered to be essential for T helper Th)2 cell development, yet in areas of primary T cell activation, CD4+ cells are its only source. This implies that other signals must drive the initial expression of IL-4 production. The role of CD28 co-stimulation in Th2 subset development has been descri
Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12.: Eur J Immunol. 1997 Mar;27(3):641-6. Unique Identifier : AIDSLINE MED/97234529; Yokoi H; Kato K; Kezuka T; Sakai J; Usui M; Yagita H; Okumura K; Department of Ophthalmology, Tokyo Medical College Hospital, Japan.; Experimental autoimmune uveoretinitis (EAU) induced by immunization with interphotoreceptor retinoid-binding protein IRBP), a retinal self antigen, has been regarded to be a typical T helper type 1 (Th1)-mediated inflammatory disease. In this study, we examined the effect of a neutralizing monoclonal antibody (mAb) to
Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression.: Eur J Immunol. 1997 Mar;27(3):647-52. Unique Identifier : AIDSLINE MED/97234530; Gollob JA; Kawasaki H; Ritz J; Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical; School, Boston, MA 02115, USA. jared_gollob@macmailgw.dfci.harvard.edu; Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) are mutually antagonistic cytokines that stimulate CD4+ T cells to develop into either Th1 or Th2 cells. One feature of Th2 differentiation in mice is the loss of IL-12-induced Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN-gamma in
Altered Th1/Th2 balance associated with non-major histocompatibility complex genes in collagen-induced arthritis in resistant and non-resistant rat strains.: Eur J Immunol. 1997 Mar;27(3):695-9. Unique Identifier : AIDSLINE MED/97234537; Mussener A; Lorentzen JC; Kleinau S; Klareskog L; Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden.; muessner@minerva.data.ks.se; Collagen-induced arthritis (CIA) is a T cell-dependent disease in which susceptibility is controlled by genes both within and outside the major histocompatibility complex (MHC). In the present study, we compared the humoral responses and kinetics of cytokine secretion patterns in the draining lymph nodes of arthritis-
Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen.: Eur J Immunol. 1997 Mar;27(3):782-7. Unique Identifier : AIDSLINE MED/97234548; Tsuji T; Hamajima K; Ishii N; Aoki I; Fukushima J; Xin KQ; Kawamoto S; Sasaki S; Matsunaga K; Ishigatsubo Y; Tani K; Okubo T; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Japan.; B7 co-stimulation is essential for activating resting T cells following antigen recognition by the T cell receptor. To determine whether B7 has adjuvant activities on human immunodeficiency virus type-1 (HIV-1)-specific immunity induced by inoculation of a plasmid encoding HIV-1 env and rev (DNA vaccine), B7-1 and B7-
Chronic pneumonia caused by Rhodococcus equi in a patient without impaired immunity.: Eur Respir J. 1997 Jan;10(1):248-50. Unique Identifier : AIDSLINE MED/97184753; Linares MJ; Lopez-Encuentra A; Perea S; Pneumology Service, Hospital Universitario, 12 de Octubre, Madrid,; Spain.; A 48 year old, human immunodeficiency virus (HIV)-negative, immunocompetent male patient had a chronic progressive pulmonary infiltrate, without radiological cavitation, in the middle lobe of the right lung produced by Rhodococcus equi. He reported direct contact with a diseased dog. The patient was diagnosed by thora
Endobronchial lesions in a non-AIDS patient with disseminated Mycobacterium avium-intracellulare infection.: Eur Respir J. 1997 Feb;10(2):497-9. Unique Identifier : AIDSLINE MED/97195249; Shih JY; Wang HC; Chiang IP; Yang PC; Luh KT; Dept of Internal Medicine, National Taiwan University Hospital,; Taipei, Republic of China.; A 34 year old female developed Mycobacterium avium-intracellulare infection with generalized lymphadenopathy, hepatosplenomegaly, pulmonary infiltration, pleural effusion and endobronchial polypoid lesions. M. avium-intracellulare was identified by means of sputum cultures, pleural effusion culture and lymph node cult
Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160.: FEBS Lett. 1997 Mar 17;405(1):68-72. Unique Identifier : AIDSLINE MED/97248198; Decroly E; Benjannet S; Savaria D; Seidah NG; J.A. DeSeve Laboratory of Biochemical Neuroendocrinology, University; of Montreal, QC, Canada.; The intracellular proteolytic processing of HIV envelope glycoprotein gp160 into gp120/gp41 is an essential step for virus infectivity. Several convertases, belonging to the pro-protein convertase family, have been proposed as candidate gp160 processing enzymes. Here we demonstrate using RT-PCR that resting human T4 l
Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice.: Diabetes. 1997 Apr;46(4):572-82. Unique Identifier : AIDSLINE MED/97230218; Baxter AG; Kinder SJ; Hammond KJ; Scollay R; Godfrey DI; Centenary Institute of Cancer Medicine and Cell Biology, Camperdown,; Australia. a.baxter@centenary.usyd.edu.au; NOD mice develop spontaneous IDDM as a result of T-cell-mediated autoimmune destruction of pancreatic beta-cells. It is not known why these T-cells become autoreactive, nor is it clear whether the breakdown in self-tolerance reflects a general problem in T-cell development or a selective defect in an as yet undefined
Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells.: Diabetes. 1997 Apr;46(4):589-98. Unique Identifier : AIDSLINE MED/97230220; Scott FW; Cloutier HE; Kleemann R; Woerz-Pagenstert U; Rowsell P; Modler HW; Kolb H; Nutrition Research Division, Health Canada, Sir Frederick Banting; Research Centre, Ottawa, Ontario. fscott@hpb.hwc.ca; Certain diets can have major effects on the development of IDDM in DP-BB rats, but data are scant on the timing, dose, and mechanisms involved. We therefore determined the dose response, timing, and duration of exposure required to induce diabetes, and characterized the effects of nutritionally adequate diets with wid
Pancreatic ductal changes in HIV-infected patients.: Gastrointest Endosc. 1997 Jan;45(1):59-63. Unique Identifier : AIDSLINE MED/97165410; Barthet M; Chauveau E; Bonnet E; Petit N; Bernard JP; Gastaut JA; Sahel J; Department of Gastroenterology and Hepatology, Hopital; Sainte-Marguerite, Marseille, France.; BACKGROUND: AIDS-related sclerosing cholangitis occurs in patients with advanced immunodeficiency, but ductal pancreatic alterations have not been evaluated in large series. METHODS: Twenty-nine consecutive patients with a mean age of 33 years underwent ERCP for biliary work-up. Complete pancreatography was obtained i
Complications following percutaneous endoscopic gastrostomy and subsequent catheter replacement in children and young adults.: Gastrointest Endosc. 1997 Jan;45(1):64-71. Unique Identifier : AIDSLINE MED/97165411; Fox VL; Abel SD; Malas S; Duggan C; Leichtner AM; Combined Program in Pediatric Gastroenterology and Nutrition,; Children's Hospital, Harvard Medical School, Boston, Massachusetts; 02115, USA.; BACKGROUND: Percutaneous endoscopic gastrostomy has gained wide acceptance for patients who require prolonged tube feeding support. We sought to identify complications and associated risk factors of endoscopic gastrostomy and subsequent catheter replacement in pediatric patients. METHODS: Medical records were reviewed
Women living with HIV/AIDS: the dual challenge of being a patient and caregiver.: Health Soc Work. 1997 Feb;22(1):53-62. Unique Identifier : AIDSLINE MED/97173518; Hackl KL; Somlai AM; Kelly JA; Kalichman SC; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53202.; More than 60,000 women in the United States have been diagnosed with AIDS, and millions of women worldwide are infected with HIV. Most of these women will die at an early age, leaving their children motherless. During their HIV illness, women confront the challenge of being both patien
Of magic bullets and social justice: emerging challenges of recent advances in AIDS treatment.: Health Soc Work. 1997 Feb;22(1):70-4. Unique Identifier : AIDSLINE MED/97173520; Linsk NL; Keigher SM; Midwest AIDS Training and Education Center, Chicago, IL, USA.
Persistent infiltration of CD45RC- CD4+ T cells, Th2-like effector cells, in prolonging hepatic allografts in rats pretreated with a donor-specific blood transfusion.: Hepatology. 1997 Apr;25(4):1008-13. Unique Identifier : AIDSLINE MED/97250929; Miyanari N; Yamaguchi Y; Matsuno K; Tominaga A; Goto M; Ichiguchi O; Mori K; Ogawa M; Department of Surgery II, Kumamoto University Medical School, Japan.; A single intravenous injection of freshly heparinized blood from a donor-specific blood transfusion (DST) seven days before transplantation significantly prolongs the subsequent survival of hepatic allografts from ACI(RT1a) to LEW(RT1(1)) rats. We used W3/25 (anti-CD4) and OX22 (anti-CD45RC: an isoform of leukocyte-co
Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B.: Hepatology. 1997 Apr;25(4):1022-7. Unique Identifier : AIDSLINE MED/97250931; Penna A; Del Prete G; Cavalli A; Bertoletti A; D'Elios MM; Sorrentino R; D'Amato M; Boni C; Pilli M; Fiaccadori F; Ferrari C; Cattedra Malattie Infettive, Universita di Parma, Italy.; The cytokine pattern secreted by T cells on viral antigen recognition is believed to exert a profound influence on both the type of disease caused by the infecting agent and the final outcome of the viral infection. To characterize the cytokine pattern associated with spontaneous resolution of acute hepatitis B, we an
In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset.: Hepatology. 1997 Apr;25(4):791-6. Unique Identifier : AIDSLINE MED/97250895; Harada K; Van de Water J; Leung PS; Coppel RL; Ansari A; Nakanuma Y; Gershwin ME; Division of Rheumatology, Allergy and Clinical Immunology, School of; Medicine, University of California, Davis 95616, USA.; Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of the intrahepatic bile ducts. It is generally believed that cellular immune mechanisms, particularly involving T cells, result in this bile duct damage. The relative strength of Th1 and Th2 responses has recently been propose
Clinical manifestations of tuberculosis: molecular mechanisms [editorial]: Indian J Chest Dis Allied Sci. 1997 Jan-Mar;39(1):1-4. Unique Identifier : AIDSLINE MED/97255039; Sharma SK; Mohan A
NASBA technology: isothermal RNA amplification in qualitative and quantitative diagnostics.: Immunol Invest. 1997 Jan-Feb;26(1-2):15-28. Unique Identifier : AIDSLINE MED/97189351; Romano JW; Williams KG; Shurtliff RN; Ginocchio C; Kaplan M; Advanced BioScience Laboratories, Inc., Kensington, MD 20895, USA.; Nucleic acid amplification technologies allow for the development of highly sensitive and specific diagnostic assays. The capacity to amplify and detect analyte targets, which may be present in a clinical sample as a single copy; is characteristic of many of these amplification technologies. NASBA is an isothermal met
HTLV-associated diseases: human retroviral infection and cutaneous T-cell lymphomas.: Immunol Invest. 1997 Jan-Feb;26(1-2):231-42. Unique Identifier : AIDSLINE MED/97189368; Fujihara K; Goldman B; Oseroff AR; Glenister N; Jaffe ES; Bisaccia E; Pincus S; Greenberg SJ; Department of Neurology, Roswell Park Cancer Institute, Buffalo, New; York 14263, USA.; An array of neurologic, oncologic, and autoimmune disorders are associated with infection with the human pathogenic retroviruses human T-cell leukemia virus types I and II (HTLV-I, II), as well as the human immunodeficiency viruses (HIV). The cutaneous T-cell lymphomas, mycosis fungoides (MF) and its hematogenous vari
Concerted use of immunologic and ultrastructural analyses in diagnostic medicine: immunoelectron microscopy and correlative microscopy.: Immunol Invest. 1997 Jan-Feb;26(1-2):29-38. Unique Identifier : AIDSLINE MED/97189352; Miller SE; Howell DN; Department of Microbiology, Duke University Medical Center, Durham,; North Carolina 27710, USA.; Electron microscopy (EM) is a valuable tool in diagnostic medicine, and in some cases, can be enhanced by immunological methods. A major medical application of EM, diagnostic virology, can frequently be augmented by employment of immunological reagents. Three immunoelectron microscopy (IEM) methods, aggregation, coati
Rapid diagnosis of periodontal infections: findings in AIDS patients.: Immunol Invest. 1997 Jan-Feb;26(1-2):55-65. Unique Identifier : AIDSLINE MED/97189354; Zambon JJ; State University of New York at Buffalo, School of Dental Medicine; 14214, USA.; A small number of bacterial pathogens in the human oral cavity cause the different forms of periodontal disease. Of the approximately two hundred different oral bacterial species, about a dozen have been associated with these diseases including localized juvenile periodontitis, rapidly progressing periodontitis, and a
Branched DNA for quantification of viral load.: Immunol Invest. 1997 Jan-Feb;26(1-2):9-13. Unique Identifier : AIDSLINE MED/97189350; Wilber JC; Chiron Corporation, Emeryville, California 94608, USA.; This is a summary of a presentation made at the 13th International Convocation on Immunology. Nucleic acids in patient samples can be quantified directly using a solid phase nucleic acid hybridization assay based on branched DNA (bDNA) signal amplification technology. For example, HIV RNA is detected in a plasma sampl
Childhood needlestick injuries in the Dublin metropolitan area.: Ir Med J. 1997 Mar;90(2):66-9. Unique Identifier : AIDSLINE MED/97258986; Nourse CB; Charles CA; McKay M; Keenan P; Butler KM; Our Lady's Hospital for Sick Children, Crumlin, Dublin.; Childhood needlestick injuries and other risk exposures outside of hospital are becoming increasingly common. A retrospective review of casenotes to ascertain the incidence, epidemiology and adequacy of management and follow-up of exposures in the Dublin metropolitan area revealed 52 cases between July 1995 and Octobe
Immunomodulatory assays to study structure-activity relationships of thalidomide.: Immunopharmacology. 1997 Jan;35(3):203-12. Unique Identifier : AIDSLINE MED/97196844; Shannon EJ; Morales MJ; Sandoval F; Laboratory Research Branch G.W. Long Hansen's Disease Center,; Louisiana State University, Baton Rouge 70894, USA.; Thalidomide, which has a long history of tragedy because of its ability to cause severe birth defects, is very effective in alleviating erythema nodosum leprosum in leprosy patients and aphthous ulcers in AIDS patients. The causes of these inflammatory diseases and the mechanism by which thalidomide diminishes them ar
In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.: Immunopharmacology. 1997 Jan;35(3):229-35. Unique Identifier : AIDSLINE MED/97196847; See DM; Broumand N; Sahl L; Tilles JG; Department of Medicine, U.C. Irvine Medical Center, Orange 92668, USA.; Extracts of Echinacea purpurea and Panax ginseng were evaluated for their capacity to stimulate cellular immune function by peripheral blood mononuclear cells (PBMC) from normal individuals and patients with either the chronic fatigue syndrome or the acquired immunodeficiency syndrome. PBMC isolated on a Ficoll-hypaqu
Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes.: Immunopharmacology. 1997 Jan;35(3):273-82. Unique Identifier : AIDSLINE MED/97196852; Hasegawa T; Kimura Y; Hiromatsu K; Kobayashi N; Yamada A; Makino M; Okuda M; Sano T; Nomoto K; Yoshikai Y; Research Laboratories, Chlorella industries Co., Ltd., Fukuoka, Japan.; We have previously reported that oral administration of hot water extract of Chlorella vulgaris (CVE) enhances resistance to Listeria monocytogenes through augmentation of Listeria-specific cell-mediated immunity in normal mice and mice with murine acquired immunodeficiency syndrome (MAIDS) caused by murine leukemia v
[Significance of T4 cells in pollinosis and colitis]: Hautarzt. 1997 Jan;48(1):55. Unique Identifier : AIDSLINE MED/97205938; Werfel T; Kapp A; Dermatologische Klinik und Poliklinik, Medizinische Hochschule; Hannover.
[HIV-associated skin diseases]: Hautarzt. 1997 Jan;48(1):58-72. Unique Identifier : AIDSLINE MED/97205939; Plettenberg A; Ramsauer J; Meigel W; Abteilung Dermatologie, Allgemeines Krankenhaus St. Georg, Hamburg.
[HIV-associated non-Hodgkin's lymphomas (HIV-NHL) in the area of the head-neck]: HNO. 1997 Jan;45(1):11-6. Unique Identifier : AIDSLINE MED/97205951; Riederer A; Dreher A; Zietz C; Bogner J; Klinik und Poliklinik fur Hals-, Nasen- und Ohrenkranke,; Ludwig-Maximilians-Universitat Munchen.; The life span of HIV-infected patients has increased because of anti-retroviral therapy and improved means for treating opportunistic infections. However, HIV infection and subsequent immunosuppression result in an increased risk of high-grade B-cell lymphomas. The purpose of this study was to determine the incidence,
HIV-proteinase inhibitors in the management of HIV-infection.: J Antimicrob Chemother. 1996 Dec;38(6):921-5. Unique Identifier : AIDSLINE MED/97176066; Moyle GJ; Barton SE; Kobler Clinic, Chelsea and Westminster Hospital, London, UK.
Stimulation of blood mononuclear cells of atopic children with the relevant allergen induces the release of eosinophil chemotaxins such as IL-3, IL-5, and GM-CSF.: J Asthma. 1997;34(2):141-52. Unique Identifier : AIDSLINE MED/97243437; Lantero S; Sacco O; Scala C; Rossi GA; Pulmonary Division, G. Gaslini Institute, Genoa, Italy.; Peripheral blood mononuclear cells (PBMC) from 10 atopic asthmatic children (atopics), sensitized to Dermatophagoides pteronyssinus (Dp), and from 5 nonatopic healthy children controls) were stimulated with Dp extract or with birch extract Be). After 6 days we tested the supernatant s (Sn) chemotactic activity toward
Purification and characterization of Mycoplasma penetrans Ca2+/Mg2+-dependent endonuclease.: J Bacteriol. 1997 Apr;179(7):2210-20. Unique Identifier : AIDSLINE MED/97234632; Bendjennat M; Blanchard A; Loutfi M; Montagnier L; Bahraoui E; Laboratory of Immunovirology UFR SVT, University of Paul Sabatier,; Toulouse, France.; The major nuclease from Mycoplasma penetrans has been purified to homogeneity. The enzyme seems to be present as a membrane-associated precursor of 50 kDa and as a peripheral membrane monomeric polypeptide of 40 kDa that is easily removed by washing of cells with isotonic buffers and in the aqueous phase upon Triton p
The eleventh international conference on AIDS: cautious celebration in Vancouver.: J Clin Pharmacol. 1997 Jan;37(1):20-4. Unique Identifier : AIDSLINE MED/97200333; Gibaldi M; Department of Pharmaceutics, School of Pharmacy, University of; Washington, Seattle 98195, USA.; For the first time in the short but turbulent history of the International Conference on AIDS (acquired immune deficiency syndrome), participants found themselves in the midst of a sea change in the treatment of human immunodeficiency virus (HIV) disease. Scientists, health policy experts, politicians, and AIDS activi
[Immunodeficiency and carcinogenesis in patients with chronic active Epstein-Barr virus infection]: Kansenshogaku Zasshi. 1997 Jan;71(1):56-64. Unique Identifier : AIDSLINE MED/97206663; Nagafuchi S; Fujisaki T; Ohshima K; Anzai K; Otsuka T; Kikuchi H; Nasu M; Kikuchi M; Sawae Y; Niho Y; First Department of Internal Medicine, Faculty of Medicine, Kyushu; University.; Three adult patients with chronic active Epstein-Barr virus infection (CAEBV) had high anti-EBV-VCA antibody, positive anti-EA, low anti-EBNA and were associated with systemic lymphadenopathies and immunosuppression. The case 1 and 2 had elevated serum immunoglobulin levels, and recurrent infections, and case 3 showed
[Clinical features of eight cases of opportunistic fungal pneumonias]: Kansenshogaku Zasshi. 1997 Jan;71(1):65-71. Unique Identifier : AIDSLINE MED/97206664; Urakami R; Nagasaka Y; Tohda Y; Ohishi M; Nakajima S; Fukuoka M; Fourth Department of Internal Medicine, Kinki University School of; Medicine, Osakasayama, Japan.; We evaluated eight cases of pulmonary mycosis in immuno compromised hosts. The underlying diseases were lung cancer with chemotherapy in one case, post bone marrow transplantation (post BMT) in two cases, acquired immunodeficiency syndrome (AIDS) in one case and bronchial asthma with massive steroid therapy in four ca
Mathematical modelling of the spread of HIV/AIDS amongst injecting drug users.: IMA J Math Appl Med Biol. 1997 Mar;14(1):11-38. Unique Identifier : AIDSLINE MED/97235567; Greenhalgh D; Hay G; Department of Statistics and Modelling Science, University of; Strathclyde, Glasgow, UK.; In this paper we develop and analyse a model for the spread of HIV/AIDS amongst a population of injecting drug users. Our work is based on a model originally due to Kaplan (1989, Rev. Inf. Diseases 11, 289-98). We start off with a brief literature survey and review; this is followed up by a detailed description of Kap
Neurodegeneration of somatostatin-immunoreactive neurons in HIV encephalitis.: J Neuropathol Exp Neurol. 1997 Apr;56(4):360-8. Unique Identifier : AIDSLINE MED/97255319; Fox L; Alford M; Achim C; Mallory M; Masliah E; University of California, San Diego, Department of Neurosciences, La; Jolla 92093-0624, USA.; Recent studies have suggested that neuronal populations that contain glutamate receptors are vulnerable to damage mediated by the human immunodeficiency virus 1 (HIV-1). Somatostatin-immunoreactive neurons contain, among other elements, glutamate receptors, and might therefore be susceptible to HIV-mediated damage. In
Clinical and neuropathological study of six patients with spastic paraparesis associated with HTLV-I: an axomyelinic degeneration of the central nervous system.: J Neuropathol Exp Neurol. 1997 Apr;56(4):403-13. Unique Identifier : AIDSLINE MED/97255324; Cartier LM; Cea JG; Vergara C; Araya F; Born P; Department of Neuroscience, Hospital del Salvador, Faculty of; Medicine, University of Chile, Santiago, Chile.; Between 1990 to 1994, 6 TSP/HAM patients, 3 women and 3 men with an average age of 57.1 years (39 to 76 years old), who died in the Salvador Hospital were submitted to postmortem examination. The mean time of paraparesis was 7 years (3 to 17 years), and 2 patients had pseudobulbar signs. Three cases had macroscopic at
Evaluation of two novel immunoassays designed to detect HIV antibodies in oral fluids.: J Clin Lab Anal. 1997;11(1):63-8. Unique Identifier : AIDSLINE MED/97173627; Saville RD; Constantine NT; Holm-Hansen C; Wisnom C; DePaola L; Falkler WA Jr; Department of Microbiology, University of Maryland School of; Dentistry, Baltimore, USA.; The testing of oral fluid samples for the detection of HIV antibodies offers several advantages over the testing of blood. Our objective was to evaluate a new generation of rapid and simple assays designed specifically to detect HIV-1 and HIV-2 antibodies in oral fluids (saliva). Serum and oral fluid pairs were collec
Quantitation of soluble E-receptor of T lymphocytes in serum from HIV-1 positive patients.: J Clin Lab Anal. 1997;11(1):69-72. Unique Identifier : AIDSLINE MED/97173628; Nunez G; Moura NC; Hernandez HJ; Peixinho ZF; Zeballos RS; Cavalcante N; Flores P; Longo IM; Mendes NF; Departamento de Microbiologia, Imunologia e Parasitologia-Disciplina; de Imunologia Escola Paulista de Medicina, Universidade Federal de Sao; paulo, Brasil.; Human T lymphocytes carry a membrane receptor for sheep erythrocytes (E) related to the CD2 molecule. The E-receptor is found in a soluble from (Rs) in serum and can be quantitated by rocket electrophoresis using an anti-Rs serum obtained by immunizing sheep with autologous erythrocytes coated with Rs. Increased seru
An immunohistochemical study of oral submucous fibrosis.: J Oral Pathol Med. 1997 Feb;26(2):75-82. Unique Identifier : AIDSLINE MED/97202379; Haque MF; Harris M; Meghji S; Speight PM; Department of Oral and Maxillofacial Surgery, Eastman Dental Institute; for Oral Health Care Sciences, University College London, UK.; Oral submucous fibrosis (OSF) is a chronic disease of the oral cavity characterized by inflammation and progressive mucosal fibrosis. These reactions may be the result of either direct stimulation from exogenous antigens like areca alkaloids or by changes in tissue antigenicity that may lead to an autoimmune response.
Cryptococcal infection in cats: factors influencing treatment outcome, and results of sequential serum antigen titers in 35 cats.: J Vet Intern Med. 1997 Jan-Feb;11(1):1-4. Unique Identifier : AIDSLINE MED/97188629; Jacobs GJ; Medleau L; Calvert C; Brown J; Department of Small Animal Medicine, College of Veterinary Medicine,; University of Georgia, Athens, USA.; The relationship between treatment outcome and location of cryptococcal infection, gender, magnitude of pretreatment cryptococcal antigen titers, results of feline leukemia virus FeLV) and feline immunodeficiency virus (FIV) serology, and serial changes in antigen titers during and after treatment were evaluated in a
IgA rheumatoid factor correlates with changes in B and T lymphocyte subsets and disease manifestations in rheumatoid arthritis.: J Rheumatol. 1997 Feb;24(2):269-74. Unique Identifier : AIDSLINE MED/97187529; Arinbjarnarson S; Jonsson T; Steinsson K; Sigfusson A; Jonsson H; Geirsson A; Thorsteinsson J; Valdimarsson H; Department of Immunology, National University Hospital, Reykjavik,; Iceland.; OBJECTIVE: To analyze the relationship between lymphocyte subsets, different rheumatoid factor (RF) isotypes, and clinical features in patients with rheumatoid arthritis (RA). METHODS: Patients with established RA (n = 95) were examined clinically and blood samples were collected for measurements of RF by ELISA and fo
The co-occurrence of acute rheumatic fever and AIDS.: J Rheumatol. 1997 Feb;24(2):404-6. Unique Identifier : AIDSLINE MED/97187553; Georgescu L; Riker C; Gibofsky A; Barland P; Department of Medicine, Hospital for Special Surgery-Cornell; University Medical Center, New York, USA.; We describe a patient with advanced acquired immunodeficiency syndrome (AIDS) who presented with evidence of carditis, arthritis, and chorea in the setting of fever, and serologic evidence for recent streptococcal infection. Several features atypical for rheumatic fever were present and included persistently high tite
Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring ring C).: J Med Chem. 1997 Mar 14;40(6):1005-17. Unique Identifier : AIDSLINE MED/97236963; Zembower DE; Liao S; Flavin MT; Xu ZQ; Stup TL; Buckheit RW Jr; Khilevich A; Mar AA; Sheinkman AK; MediChem Research, Inc., Lemont, Illinois 60439, USA.; (+)-Calanolide A is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1), which was isolated from an extract of Calophyllum lanigerum, along with seven related compounds. In order to examine the structure-activity relationships of the trans-10,11-dimethyldihydropyran-12-ol ring
Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.: J Med Chem. 1997 Mar 14;40(6):885-97. Unique Identifier : AIDSLINE MED/97236949; Hulten J; Bonham NM; Nillroth U; Hansson T; Zuccarello G; Bouzide A; Aqvist J; Classon B; Danielson UH; Karlen A; Kvarnstrom I; Samuelsson B; Hallberg A; Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical; Center, Uppsala University, Sweden.; Ten C2-symmetric cyclic urea and sulfamide derivatives have been synthesized from L-mannonic gamma-lactone and D-mannitol. The results of experimental measurement of their inhibitory potencies against HIV-1 protease were compared to calculated free energies of binding derived from molecular dynamics (MD) simulations.
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.: J Med Chem. 1997 Mar 14;40(6):898-902. Unique Identifier : AIDSLINE MED/97236950; Backbro K; Lowgren S; Osterlund K; Atepo J; Unge T; Hulten; Bonham NM; Schaal W; Karlen A; Hallberg A; Department of Molecular Biology, Uppsala University, Sweden.; Two cyclic, C2-symmetric HIV-1 protease inhibitors , one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1 positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 A resolution. The struc
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.: J Med Chem. 1997 Mar 14;40(6):920-9. Unique Identifier : AIDSLINE MED/97236952; Nicklaus MC; Neamati N; Hong H; Mazumder A; Sunder S; Chen J; Milne GW; Pommier Y; Laboratory of Medicinal Chemistry, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.; Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester CAPE), a putative three-point pharmacophore for binding of inhibitors to IN was derived. This pharmacophore was used to search the National Cancer Institute three-dimensional (3D) structural data
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.: J Med Chem. 1997 Mar 14;40(6):930-6. Unique Identifier : AIDSLINE MED/97236953; Hong H; Neamati N; Wang S; Nicklaus MC; Mazumder A; Zhao H; Burke TR Jr; Pommier Y; Milne GW; Laboratory of Medicinal Chemistry, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.; Based upon a class of known HIV-1 integrase inhibitors, several pharmacophore models were proposed from molecular modeling studies and validated using a 3D database of 152, compounds for which integrase assay data are known. Using the most probable pharmacophore model as the query, the NCI 3D database of 206,876 compo
Hydrazide-containing inhibitors of HIV-1 integrase.: J Med Chem. 1997 Mar 14;40(6):937-41. Unique Identifier : AIDSLINE MED/97236954; Zhao H; Neamati N; Sunder S; Hong H; Wang S; Milne GW; Pommier Y; Burke TR Jr; Laboratory of Medicinal Chemistry, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; Inhibitors of HIV integrase are currently being sought as potential new therapeutics for the treatment of AIDS. A large number of inhibitors discovered to date contain the o-bis-hydroxy catechol structure. In an effort to discover structural leads for the development of new HIV integrase inhibitors which do not rely o
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.: J Med Chem. 1997 Mar 14;40(6):942-51. Unique Identifier : AIDSLINE MED/97236955; Neamati N; Hong H; Mazumder A; Wang S; Sunder S; Nicklaus MC; Milne GW; Proksa B; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Institute,; Bethesda, Maryland 20892-4255, USA.; Seventeen lichen acids comprising despides, depsidones, and their synthetic derivatives have been examined for their inhibitory activity against HIV-1 integrase, and two pharmacophores associated with inhibition of this enzyme have been identified. A search of the NCI 3D database of approximately 200,000 structures yi
Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.: J Med Chem. 1997 Mar 28;40(7):1149-64. Unique Identifier : AIDSLINE MED/97244496; Skulnick HI; Johnson PD; Aristoff PA; Morris JK; Lovasz KD; Howe WJ; Watenpaugh KD; Janakiraman MN; Anderson DJ; Reischer RJ; Schwartz TM; Banitt LS; Tomich PK; Lynn JC; Horng MM; Chong KT; Hinshaw RR; Dolak LA; Seest EP; Schwende FJ; Rush BD; Howard GM; Toth LN; Wilkinson KR; Romines KR; et al; Discovery Chemistry Research, Pharmacia and Upjohn, Kalamazoo,; Michigan 49001, USA.; Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors , but these compounds lacked significant antiviral activity in cell culture. Substitution of a sulfonamide group at the m
Occurrence and frequency of transmission of naturally occurring simian retroviral infections (SIV, STLV, and SRV) at the CIRMF Primate Center, Gabon.: J Med Primatol. 1996 Oct;25(5):313-26. Unique Identifier : AIDSLINE MED/97181234; Georges-Courbot MC; Moisson P; Leroy E; Pingard AM; Nerrienet E; Dubreuil G; Wickings EJ; Debels F; Bedjabaga I; Poaty-Mavoungou V; Hahn NT; Georges AJ; Centre International de Recherches Medicales (CIRMF), Franceville,; Gabon.; Among the primates held at the CIRMF Primate Center, Gabon , no serological sign of SIV infection could be demonstrated in 68 cynomolgus monkeys, 60 chimpanzees, nine gorillas, and 12 sun-tailed monkeys, while seven of 102 mandrills and six of 24 vervets were infected with SIV. Six m
A dynamic in vivo view of the HIV-I Rev-RRE interaction.: J Mol Biol. 1997 Mar 14;266(5):950-62. Unique Identifier : AIDSLINE MED/97240813; Charpentier B; Stutz F; Rosbash M; Department of Biology, Brandeis University, Waltham, MA 02254, USA.; The export of pre-mRNAs coding for the structural genes of the human immunodeficiency virus type I depends on the interaction of the Rev protein with a highly structured viral RNA sequence, the Rev-responsive element (RRE). To gain information about the structure of the RRE and the determinants of the in vivo RRE-Rev
Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization.: J Virol. 1997 May;71(5):3397-406. Unique Identifier : AIDSLINE MED/97248381; Laughrea M; Jette L; Mak J; Kleiman L; Liang C; Wainberg MA; McGill AIDS Centre, Lady Davis Institute for Medical Research, Sir; Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.; A stem-loop termed the kissing-loop hairpin is one of the most highly conserved structures within the leader of human immunodeficiency virus type 1 (HIV-1) and chimpanzee immunodeficiency virus genomic RNA. Because it plays a key role in the in vitro dimerization of short HIV-1 RNA transcripts (M. Laughrea and L. Jett
Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation.: J Virol. 1997 May;71(5):3407-14. Unique Identifier : AIDSLINE MED/97248382; Clever JL; Parslow TG; Department of Pathology, University of California, San Francisco; 94143, USA.; Retrovirus particles each contain two copies of the viral genome in the form of a noncovalently linked RNA dimer. Earlier studies have mapped a cis-acting region near the 5 end of the human immunodeficiency virus type 1 (HIV-1) genome, termed the psi locus, which appears essential for initiation of genomic dimerizati
Transcriptional patterns of the pCD41 (U27) locus of human herpesvirus 6.: J Virol. 1997 May;71(5):3420-30. Unique Identifier : AIDSLINE MED/97248384; Zhou Y; Chandran B; Wood C; Department of Microbiology, University of Miami School of Medicine,; Florida 33101, USA.; Human herpesvirus 6 (HHV-6) is a lymphotropic herpesvirus, and in vitro, it can productively infect many of the same cell types that human immunodeficiency virus (HIV) infects. Simultaneous infection of T cells by HIV and HHV-6 can lead to both activation of the HIV promoter and acceleration of the cytopathic effects.
Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions.: J Virol. 1997 May;71(5):3444-50. Unique Identifier : AIDSLINE MED/97248387; Bastiani L; Laal S; Kim M; Zolla-Pazner S; Department of Pathology, NYU Medical Center, New York, New York 10016,; USA.; In addition to gp41 and gp120, an array of cell adhesion molecules is present on the envelope of human immunodeficiency virus type 1 (HIV-1). To examine the role of the host cell in the acquisition of these molecules by virions, both laboratory-adapted and primary isolates were sequentially passaged into different hos
Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17.: J Virol. 1997 May;71(5):3474-83. Unique Identifier : AIDSLINE MED/97248391; Cannon PM; Matthews S; Clark N; Byles ED; Iourin O; Hockley DJ; Kingsman SM; Kingsman AJ; Department of Biochemistry, University of Oxford, United Kingdom.; The human immunodeficiency virus type 1 (HIV-1) matrix protein, p17, plays important roles in both the early and late stages of the viral life cycle. Using our previously determined solution structure of p17, we have undertaken a rational mutagenesis program aimed at mapping structure-function relationships within the
The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins.: J Virol. 1997 May;71(5):3484-97. Unique Identifier : AIDSLINE MED/97248392; Bex F; McDowall A; Burny A; Gaynor R; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas 75235-8594/9072, USA. bex@utsw.swmed.edu; The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transcription. Tax also activates the expression of specific cellular genes involved in the control of T-lymphocyte growth via effects on cellular transcription factors, including members of the NF-kappaB/cRel family. Immunoc
Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower human female reproductive tract.: J Virol. 1997 May;71(5):3498-506. Unique Identifier : AIDSLINE MED/97248393; Howell AL; Edkins RD; Rier SE; Yeaman GR; Stern JE; Fanger MW; Wira CR; Department of Veterans Affairs, White River Junction, Vermont 05009,; USA. alexandra.howell@dartmouth.EDU; Viable tissue sections and isolated cell cultures from the human fallopian tube, uterus, cervix, and vaginal mucosa were examined for susceptibility to infection with human immunodeficiency virus type 1 (HIV-1). We examined infectivity by using the monocytotropic strain HIV-1(JR-FL) and several primary isolates of HIV
Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.: J Virol. 1997 May;71(5):3507-14. Unique Identifier : AIDSLINE MED/97248394; Engelman A; Liu Y; Chen H; Farzan M; Dyda F; Dana-Farber Cancer Institute and Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115, USA.; Two different crystal structures of the human immunodeficiency virus type 1 (HIV-1) integrase (IN) catalytic domain were analyzed for interactions at the enzyme active site. Gln-62 and Glu-92 interact with active-site residue Asp-64, and Lys-136 interacts with active-site residue Asp-116 across a dimer interface. Cons
Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.: J Virol. 1997 May;71(5):3563-73. Unique Identifier : AIDSLINE MED/97248400; Bassuk AG; Anandappa RT; Leiden JM; Department of Medicine, University of Chicago, Illinois 60637, USA.; The transcriptional regulatory elements of many inducible T-cell genes contain adjacent or overlapping binding sites for the Ets and NF-kappaB/NFAT families of transcription factors. Similar arrays of functionally important NF-kappaB/NFAT and Ets binding sites are present in the transcriptional enhancers of human immu
Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity.: J Virol. 1997 May;71(5):3588-96. Unique Identifier : AIDSLINE MED/97248403; Fortin JF; Cantin R; Lamontagne G; Tremblay M; Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire; de Quebec, Ste-Foy, Canada.; Human immunodeficiency virus type 1 (HIV-1) acquires several host cell membrane proteins when it buds from infected cells. To study the effect of virally incorporated host-derived ICAM-1 glycoproteins on the biology of HIV-1, we have developed a transient expression system that has enabled us to produce virus particle
Inflammatory cytokine expression is correlated with the level of human immunodeficiency virus (HIV) transcripts in HIV-infected placental trophoblastic cells.: J Virol. 1997 May;71(5):3628-35. Unique Identifier : AIDSLINE MED/97248408; Lee BN; Ordonez N; Popek EJ; Lu JG; Helfgott A; Eriksen N; Hammill H; Kozinetz C; Doyle M; Kline M; Langston C; Shearer WT; Reuben JM; Division of Laboratory Medicine, University of Texas M. D. Anderson; Cancer Center, Houston 77030, USA.; The inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNF-alpha) have been associated with increased human immunodeficiency virus (HIV) expression and enhanced lymphocyte adhesion to trophoblastic cells in experimental systems. To determine if there is a correlation between th
The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable.: J Virol. 1997 May;71(5):3641-51. Unique Identifier : AIDSLINE MED/97248410; Sinclair E; Barbosa P; Feinberg MB; Gladstone Institute of Virology and Immunology, San Francisco,; California 94141-100, USA.; Adult rhesus macaques infected with nef-defective simian immunodeficiency virus (SIV) exhibit extremely low levels of steady-state virus replication, do not succumb to immunodeficiency disease, and are protected from experimental challenge with pathogenic isolates of SIV. Similarly, rare humans found to be infected wi
Complete nucleotide sequence of simian endogenous type D retrovirus with intact genome organization: evidence for ancestry to simian retrovirus and baboon endogenous virus.: J Virol. 1997 May;71(5):3666-76. Unique Identifier : AIDSLINE MED/97248412; van der Kuyl AC; Mang R; Dekker JT; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre, Amsterdam,; The Netherlands. Kuyl@amc.uva.nl; A complete endogenous type D viral genome has been isolated from a baboon genomic library. The provirus, simian endogenous retrovirus (SERV), is 8,393 nucleotides long and contains two long terminal repeats and complete genes for gag, pro, pol, and env. The primer binding site is complementary to tRNA(Lys)3, like in l
The simian T-lymphotropic/leukemia virus from Pan paniscus belongs to the type 2 family and infects Asian macaques.: J Virol. 1997 May;71(5):3684-92. Unique Identifier : AIDSLINE MED/97248414; Digilio L; Giri A; Cho N; Slattery J; Markham P; Franchini G; Laboratory of Basic Research, National Cancer Institute, Bethesda,; Maryland 20892-4255, USA.; The proviral DNA of the simian T-leukemia/lymphotropic virus STLV) isolate, originally obtained from a captive colony of pygmy chimpanzees (Pan paniscus) (STLV(pan-p)), was cloned from the DNA of the chronically infected human T-cell line L93-79B. The entire proviral DNA sequence was obtained and compared with sequenc
A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells.: J Virol. 1997 May;71(5):3693-701. Unique Identifier : AIDSLINE MED/97248415; Moreno TN; Fortunato EA; Hsia K; Spector SA; Spector DH; Department of Biology, University of California, San Diego, La Jolla; 92093-0357, USA.; Previously, our laboratory showed that human cytomegalovirus HCMV) activates human immunodeficiency virus type 1 (HIV-1) in brain-derived cells with limited HIV-1 gene expression but inhibits HIV-1 in cells fully permissive for replication of both viruses (F. M. Jault, S. A. Specto
Modulation of murine AIDS-related pathology by concurrent antibody treatment and coinfection with Leishmania major.: J Virol. 1997 May;71(5):3702-9. Unique Identifier : AIDSLINE MED/97248416; Doherty TM; Giese N; Morse HC 3rd; Coffman RL; Laboratory of Parasitic Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892, USA.; Infection of C57BL/6 mice with a mixture of murine leukemia viruses (MuLVs) designated LP-BM5 MuLV leads to a disease characterized by progressive immunodeficiency and lymphoproliferation, known as murine AIDS (MAIDS). The development of MAIDS is associated with increased B-cell lymphoblast proliferation, but there is
Autologous and heterologous neutralizing antibody responses following initial seroconversion in human immunodeficiency virus type 1-infected individuals.: J Virol. 1997 May;71(5):3734-41. Unique Identifier : AIDSLINE MED/97248420; Moog C; Fleury HJ; Pellegrin I; Kirn A; Aubertin AM; INSERM U74, Institut de Virologie, Strasbourg, France.; In the course of human immunodeficiency virus type 1 (HIV-1) infection, patients develop a strong and persistent immune response characterized by the production of HIV-specific antibodies. The aim of our study was to analyze the appearance of autologous and heterologous neutralizing antibodies in the sera of HIV-infec
Induction of T-cell apoptosis by human herpesvirus 6.: J Virol. 1997 May;71(5):3751-9. Unique Identifier : AIDSLINE MED/97248422; Inoue Y; Yasukawa M; Fujita S; First Department of Internal Medicine, Ehime University School of; Medicine, Shigenobu, Japan.; The mechanisms of cell death in CD4+ T cells mediated by human herpesvirus 6 (HHV-6) were investigated. The frequency of cell death in the human CD4+ T-cell line JJHAN, which had been inoculated with HHV-6 variant A or B, appeared to be augmented by tumor necrosis factor alpha (TNF-alpha). Agarose gel electrophoresis
Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.: J Virol. 1997 May;71(5):3776-87. Unique Identifier : AIDSLINE MED/97248425; Page KA; van Schooten WC; Feinberg MB; Department of Microbiology and Immunology, University of; California-San Francisco 94141-9100, USA. page@wpo.sosc.osshe.edu; We have developed an in vitro model to study the influence that human immunodeficiency virus type 1 (HIV-1) may have on the ability of T cells to respond to antigenic challenge. We have examined consequences of HIV-1 gene expression on T-cell activation in antigen-dependent T cells that have stably integrated copies o
Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.: J Virol. 1997 May;71(5):3872-8. Unique Identifier : AIDSLINE MED/97248435; Sasadeusz JJ; Tufaro F; Safrin S; Schubert K; Hubinette MM; Cheung PK; Sacks SL; Department of Medicine, University of British Columbia, Vancouver,; Canada.; In the majority of cases, the mechanism underlying the resistance to acyclovir (ACV) of herpes simplex viruses (HSVs) is thymidine kinase (TK) deficiency. Plaque isolates from eight ACV-resistant ACVr) clinical isolates from AIDS patients, of which five reactivated, were sequenc
Assembled coronavirus from complementation of two defective interfering RNAs.: J Virol. 1997 May;71(5):3922-31. Unique Identifier : AIDSLINE MED/97248441; Kim KH; Narayanan K; Makino S; Department of Microbiology, The University of Texas at Austin, 78712,; USA.; In the presence of an RNA- temperature-sensitive (ts) mutant helper virus, two coronavirus mouse hepatitis virus (MHV) defective interfering (DI) RNAs complemented each other, resulting in the assembly of MHV particles; we used this ability to complement as a means to study coronavirus assembly. One of the two DI RNAs
Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection.: J Virol. 1997 May;71(5):3932-9. Unique Identifier : AIDSLINE MED/97248442; Chackerian B; Long EM; Luciw PA; Overbaugh J; Department of Microbiology, University of Washington, Seattle 98195,; USA.; Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest
Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.: J Virol. 1997 May;71(5):3953-60. Unique Identifier : AIDSLINE MED/97248444; Chen Z; Luckay A; Sodora DL; Telfer P; Reed P; Gettie A; Kanu JM; Sadek RF; Yee J; Ho DD; Zhang L; Marx PA; Aaron Diamond AIDS Research Center, Rockefeller University, New York,; New York 10016, USA.; The extent of zoonotic infections in rural Sierra Leone , where both feral and pet sooty mangabeys harbor divergent members of the human immunodeficiency virus type 2 (HIV-2)-sooty mangabey simian immunodeficiency virus (SIVsm) family, was tested in blood samples collected from
Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.: J Virol. 1997 May;71(5):3961-71. Unique Identifier : AIDSLINE MED/97248445; Poon B; Jowett JB; Stewart SA; Armstrong RW; Rishton GM; Chen IS; Department of Microbiology and Immunology, UCLA School of Medicine,; Los Angeles, California 90095, USA.; The product of the human immunodeficiency virus type 1 (HIV-1) vpr gene induces cell cycle arrest in the G2 phase of the cell cycle and is characterized by an accumulation of the hyperphosphorylated form of cdc2 kinase. This phenotype is similar to the effect of DNA-damaging agents, which can also cause cells to arres
Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: intravaginal and oral deposition of simian/human immunodeficiency virus in macaques results in systemic infection, elimination of CD4+ T cells, and AIDS.: J Virol. 1997 May;71(5):4016-23. Unique Identifier : AIDSLINE MED/97248451; Joag SV; Adany I; Li Z; Foresman L; Pinson DM; Wang C; Stephens EB; Raghavan R; Narayan O; Department of Microbiology, University of Kansas Medical Center,; Kansas City 66160-7424, USA.; Chimeric simian/human immunodeficiency virus (SHIV) consists of the env, vpu, tat, and rev genes of human immunodeficiency virus type 1 (HIV-1) on a background of simian immunodeficiency virus SIV). We derived a SHIV that caused CD4+ cell loss and AIDS in pig-tailed macaques (S. V. Joag, Z. Li, L. Foresman, E. B. Step
Endocytosis and recycling of varicella-zoster virus Fc receptor glycoprotein gE: internalization mediated by a YXXL motif in the cytoplasmic tail.: J Virol. 1997 May;71(5):4042-54. Unique Identifier : AIDSLINE MED/97248454; Olson JK; Grose C; Department of Microbiology and Immunology Program, University of Iowa; College of Medicine, Iowa City 52242, USA.; Varicella-zoster virus (VZV) encodes a cell surface Fc receptor, glycoprotein gE. VZV gE has previously been shown to display several features common to nonviral cell surface receptors. Most recently, VZV gE was reported to be tyrosine phosphorylated on a dimeric form (J. K. Olson, G. A. Bishop, and C. Grose, J. Virol
Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector.: J Virol. 1997 May;71(5):4071-8. Unique Identifier : AIDSLINE MED/97248457; Inouye RT; Du B; Boldt-Houle D; Ferrante A; Park IW; Hammer SM; Duan L; Groopman JE; Pomerantz RJ; Terwilliger EF; Division of Experimental Medicine, Beth Israel Deaconess Medical; Center and Harvard Institutes of Medicine, Boston, Massachusetts; 02215, USA.; The rate of viral replication appears to play a pivotal role in human immunodeficiency virus type 1 (HIV-1) pathogenesis and disease progression as it outstrips the capacity of the immune system to respond. Important cellular sites for HIV-1 production include T lymphocytes and tissue macrophages. Antiviral strategies
Stable human immunodeficiency virus type 1 (HIV-1) resistance in transformed CD4+ monocytic cells treated with multitargeting HIV-1 antisense sequences incorporated into U1 snRNA.: J Virol. 1997 May;71(5):4079-85. Unique Identifier : AIDSLINE MED/97248458; Liu D; Donegan J; Nuovo G; Mitra D; Laurence J; Enzo Biochem, Inc., Farmingdale, New York 11735, USA. dl@enzobio.com; We have approached the development of a human immunodeficiency virus type 1 (HIV-1) therapeutic product by producing immune cells stably resistant to HIV-1. Promonocytic CD4+ cells (U937) were made resistant to HIV-1 by the introduction of a DNA construct (pNDU1A,B,C) that contained three independent antisense sequenc
Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1.: J Virol. 1997 May;71(5):4086-91. Unique Identifier : AIDSLINE MED/97248459; Novembre FJ; Saucier M; Anderson DC; Klumpp SA; O'Neil SP; Brown CR 2nd; Hart CE; Guenthner PC; Swenson RB; McClure HM; Department of Pathology, Emory University, Atlanta, Georgia, USA.; fnovembr@rmy.emory.edu; The condition of a chimpanzee (C499) infected with three different isolates of human immunodeficiency virus type 1 (HIV-1) for over 10 years progressed to AIDS. Disease development in this animal was characterized by (i) a decline in CD4+ cells over the last 3 years; (ii) an increase in viral loads in plasma; (iii) th
Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat.: J Virol. 1997 May;71(5):4098-102. Unique Identifier : AIDSLINE MED/97248461; Li YP; Department of Medicine, Baylor College of Medicine, Houston, Texas; 77030, USA. yiping@tmc.bcm.edu; Nucleolar shuttle protein B23 was found to bind to human immunodeficiency virus protein Tat, and this binding required the nucleolar localization motif of Tat. A fusion protein containing the B23 binding domain and beta-galactosidase caused mislocalization of Tat to the cytoplasm and inhibited the transactivation acti
Defective herpes simplex virus type 1 vectors harboring gag, pol, and env genes can be used to rescue defective retrovirus vectors.: J Virol. 1997 May;71(5):4111-7. Unique Identifier : AIDSLINE MED/97248464; Savard N; Cosset FL; Epstein AL; Centre de Genetique Moleculaire et Cellulaire, UMR 5534 CNRS,; Universite Claude Bernard Lyon I, Villeurbanne, France.; A retroviral packaging transcription unit was constructed in which the Moloney murine leukemia virus (MoMLV) gag-pol and env genes are expressed under the control of herpesvirus regulatory sequences. This transcription unit, lacking long terminal repeats, primer binding sites, and most of the retrovirus packaging sign
Location of cis-acting signals important for RNA encapsidation in the leader sequence of human immunodeficiency virus type 2.: J Virol. 1997 May;71(5):4133-7. Unique Identifier : AIDSLINE MED/97248468; McCann EM; Lever AM; University of Cambridge Department of Medicine, Addenbrooke's; Hospital, United Kingdom.; We used a series of deletion mutations in the untranslated leader region of human immunodeficiency virus type 2 (HIV-2) to seek cis-acting packaging signals. Sequences between the 5 major splice donor and the gag initiation codon, where such signals have been identified in HIV-1, appear to make a measurable but very
Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species.: J Virol. 1997 May;71(5):4138-44. Unique Identifier : AIDSLINE MED/97248469; Rose TM; Strand KB; Schultz ER; Schaefer G; Rankin GW Jr; Thouless ME; Tsai CC; Bosch ML; Department of Pathobiology, School of Public Health and Community; Medicine, University of Washington, Seattle 98195, USA.; trose@u.washington.edu; Simian retroperitoneal fibromatosis (RF) is a vascular fibroproliferative neoplasm which has many morphological and histological similarities to human Kaposi s sarcoma (KS). Like epidemic KS in AIDS patients, RF is highly associated with an immunodeficiency syndrome (simian acquired immunodeficiency syndrome [SAIDS])
55- and 75-kilodalton tumor necrosis factor receptors mediate distinct actions in regard to human immunodeficiency virus type 1 replication in primary human macrophages.: J Virol. 1997 May;71(5):4150-6. Unique Identifier : AIDSLINE MED/97248471; Herbein G; Gordon S; Virology Institute of the Faculty of Medicine and INSERM Unit 74,; Louis Pasteur University, Strasbourg, France.; We report in this study that repeated tumor necrosis factor alpha TNF-alpha) pretreatment, starting before and continued after infection by human immunodeficiency virus type 1 (HIV-1), inhibits replication of the monocytotropic Ada strain in primary tissue culture-differentiated macrophages (TCDM), as assessed by sixf
Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice.: J Virol. 1997 May;71(5):4161-4. Unique Identifier : AIDSLINE MED/97248473; Gulizia RJ; Collman RG; Levy JA; Trono D; Mosier DE; Department of Immunology-IMM7, The Scripps Research Institute, La; Jolla, California 92037, USA.; The pathogenicity of four human immunodeficiency virus type 1 HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infec
CD8+ T cells can mediate almost complete short-term and partial long-term immunity to rotavirus in mice.: J Virol. 1997 May;71(5):4165-70. Unique Identifier : AIDSLINE MED/97248474; Franco MA; Tin C; Greenberg HB; Veterans Administration Palo Alto Health Care System and Department of; Medicine, Stanford University School of Medicine, California 94305,; USA. francoma@leland.stanford.edu; We have recently shown that CD8+ T cells mediate clearance of rotavirus infection in mice. B-cell-deficient J(H)D knockout mice depleted of CD8+ T cells become chronically infected with murine rotavirus, and beta2 microglobulin -/- and other mice depleted of CD8+ T cells have a 1- to 4-day delay in clearance of primar
Protease inhibitors bring new social, clinical uncertainties to HIV care [news]: JAMA. 1997 Apr 16;277(15):1182, 1184. Unique Identifier : AIDSLINE MED/97256487; Voelker R
Syringe and needle regulation, blood-borne disease transmission, and concern for public safety [letter]: JAMA. 1997 Apr 16;277(15):1202-3; discussion 1203. Unique Identifier : AIDSLINE MED/97256500; Friedland G
Syringe and needle regulation, blood-borne disease transmission, and concern for public safety [letter; comment]: JAMA. 1997 Apr 16;277(15):1203; discussion 1203. Unique Identifier : AIDSLINE MED/97256501; Tsao K; Roaf EA
[Clinical course of HIV-infected tuberculosis patients who admitted to the tuberculosis isolation ward: current problems of medical care]: Kekkaku. 1997 Feb;72(2):67-72. Unique Identifier : AIDSLINE MED/97224704; Fujita A; Suzuki A; Hamaoka T; Tojima H; Department of Pulmonary Medicine, Tokyo Metropolitan Fuchu Hospital,; Japan.; To clarify the problems of medical care of HIV-infected tuberculosis patients, we investigated clinical course of six cases admitted to our tuberculosis isolation ward. All cases were sputum smear positive for tubercle bacilli at the time of diagnosis of tuberculosis. HIV-positive was confirmed at the same time or soo
[A case of acquired immunodeficiency syndrome with disseminated Mycobacterium avium complex infection in which M. avium was isolated from bone marrow]: Kekkaku. 1997 Feb;72(2):73-7. Unique Identifier : AIDSLINE MED/97224705; Ohse H; Saito T; Kadono K; Hirano K; Watanabe S; Nemoto E; Fukai S; Yanai N; Ishii Y; Hasegawa S; National Seiranso Hospital, Ibaraki, Japan.; A 46-year old man was admitted to a hospital because of cough and dyspnea. He was diagnosed as interstitial pneumonia and was treated with prednisolone (PSL) and antibiotics. The symptoms improved temporarily but he soon developed acute respiratory failure and was transferred to our hospital. Chest X-ray and CT reveal
[Saprophytic and invasive pulmonary aspergillosis]: Kekkaku. 1997 Feb;72(2):99-107. Unique Identifier : AIDSLINE MED/97224709; Nagai H; Department of Pulmonary Diseases, Tokyo National Chest Hospital,; Japan.; The characteristics of chest x-ray films in 19 patients with saprophytic pulmonary aspergillosis secondary to acid-fast bacilli infection were reported. The saprophytic form, exemplified by the classic fungus ball or mycetoma, results from the growth of fungal mycelia within a pre-existing area of destroyed lung, typi
Dynamic multidrug therapies for HIV: a control theoretic approach.: J Theor Biol. 1997 Mar 7;185(1):15-29. Unique Identifier : AIDSLINE MED/97247425; Wein LM; Zenios SA; Nowak MA; Sloan School of Management, M.I.T., Cambridge, MA 02139, USA.; Motivated by the inability of current drug treatment to provide long-term benefit to HIV-infected individuals, we derive HIV therapeutic strategies by formulating and analyzing a mathematical control problem. The model tracks the dynamics of uninfected and infected CD4+ cells and free plasma virus, and allows the viru
9-year HIV-2-associated mortality in an urban community in Bissau, west Africa.: Lancet. 1997 Mar 29;349(9056):911-4. Unique Identifier : AIDSLINE MED/97247118; Poulsen AG; Aaby P; Larsen O; Jensen H; Naucler A; Lisse IM; Christiansen CB; Dias F; Melbye M; Department of Epidemiology Research, Danish Epidemiology Science; Centre.; BACKGROUND: Community studies with 1-3 years of follow-up have reported four to five times higher mortality in HIV-2-infected than in uninfected adults. In a cohort study of HIV-1, an increasing difference in mortality rates of HIV-1-infected and uninfected individuals is expected over time, because of rising mortalit
32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes [letter]: Lancet. 1997 Mar 29;349(9056):922-3. Unique Identifier : AIDSLINE MED/97247123; Rappaport J; Cho YY; Hendel H; Schwartz EJ; Schachter F; Zagury JF
Severe hepatitis in three AIDS patients treated with indinavir [letter]: Lancet. 1997 Mar 29;349(9056):924-5. Unique Identifier : AIDSLINE MED/97247126; Brau N; Leaf HL; Wieczorek RL; Margolis DM
Will Egypt escape the AIDS epidemic? [news]: Lancet. 1997 Apr 5;349(9057):1005. Unique Identifier : AIDSLINE MED/97255290; Lenton C
Personal screening for HIV revisited [letter; comment]: Lancet. 1997 Apr 5;349(9057):1032. Unique Identifier : AIDSLINE MED/97255315; Frerichs RR
Restoration of immunity to chronic hepatitis B infection in HIV-infected patient on protease inhibitor [letter]: Lancet. 1997 Apr 5;349(9057):995-6. Unique Identifier : AIDSLINE MED/97255282; Carr A; Cooper DA
HTLV-I provirus in seronegative healthy blood donors [letter]: Lancet. 1997 Apr 5;349(9057):999. Unique Identifier : AIDSLINE MED/97255286; Zucker-Franklin D; Gorman JG
Emerging international consensus for use of antiretroviral therapy [see comments]: Lancet. 1997 Apr 12;349(9058):1042. Unique Identifier : AIDSLINE MED/97261286; Montaner JS; Hogg RS; O'Shaughnessy MV; Centre for Excellence on HIV/AIDS, Canadian HIV Trials Network; St; Paul's Hospital/University of British Columbia, Vancouver, Canada.
Late postnatal mother-to-child transmission of HIV-1 in Abidjan, Cote d'Ivoire.: Lancet. 1997 Apr 12;349(9058):1054-9. Unique Identifier : AIDSLINE MED/97261289; Ekpini ER; Wiktor SZ; Satten GA; Adjorlolo-Johnson GT; Sibailly TS; Ou CY; Karon JM; Brattegaard K; Whitaker JP; Gnaore E; De Cock KM; Greenberg AE; Project RETRO-CI, Abidjan, Cote d'Ivoire.; BACKGROUND: HIV-1 can be transmitted from an infected mother to her infant through breastfeeding, although the precise risk of transmission by this route is unknown. A long-term follow-up of children born to HIV-infected women in Abidjan, Cote d Ivoire , has enabled us to estim
Nonoxynol-9 fails to protect against HIV-1 [news]: Lancet. 1997 Apr 12;349(9058):1074. Unique Identifier : AIDSLINE MED/97261300; Rowe PM
Chemokines join fight against HIV-1 infection [news]: Lancet. 1997 Apr 12;349(9058):1075. Unique Identifier : AIDSLINE MED/97261301; Morris K
US Congress examines new approach to HIV [news]: Lancet. 1997 Apr 12;349(9058):1078. Unique Identifier : AIDSLINE MED/97261302; Rovner J
Israeli ministries delay implementation of requirement to reveal HIV status [news]: Lancet. 1997 Apr 12;349(9058):1080. Unique Identifier : AIDSLINE MED/97261303; Fishman RH
British HIV Association guidelines for antiretroviral treatment of HIV seropositive individuals. BHIVA Guidelines Co-ordinating Committee [see comments]: Lancet. 1997 Apr 12;349(9058):1086-92. Unique Identifier : AIDSLINE MED/97261305; Only incomplete data are available to guide decision on anti-HIV treatment. A British HIV Association consensus is that guidance must draw on other evidence besides the randomised trial. Marker studies, work on disease pathogenesis and viral dynamics, and expanding knowledge of resistance patterns mean that the approa
Cryptosporidiosis in Houston, Texas. A report of 95 cases.: Medicine (Baltimore). 1997 Mar;76(2):118-39. Unique Identifier : AIDSLINE MED/97255392; Hashmey R; Smith NH; Cron S; Graviss EA; Chappell CL; White AC Jr; Department of Medicine, Baylor College of Medicine, Ben Taub General; Hospital, Houston, TX 77030, USA.; Cryptosporidiosis is an important cause of diarrhea. We identified 95 patients with cryptosporidiosis over a 6-year period in our county hospital system, including 9 children and 86 adults infected with the human immunodeficiency virus (HIV). Risk factors included male-to-male sexual practices and Hispanic race. Diarr
Caring for persons with AIDS in greater Minnesota.: Minn Med. 1997 Feb;80(2):43-5. Unique Identifier : AIDSLINE MED/97202897; Chial H; Elliott BA; University of Minnesota Medical School, USA.; This study identifies ways in which physicians in rural and nonurban settings can better meet the needs of caregivers for persons with HIV/AIDS. We interviewed 14 caregivers living in these settings and documented their experiences and needs. Caregivers indicated that physicians had been providing needed medical care,
Screening pregnant women for HIV.: Minn Med. 1997 Feb;80(2):48-50. Unique Identifier : AIDSLINE MED/97202898; Lupo VR; Department of Obstetrics and Gynecology, University of Minnesota, USA.
Identification of HIV-1 group O infection--Los Angeles county, California, 1996.: MMWR Morb Mortal Wkly Rep. 1996 Jul 5;45(26):561-5. Unique Identifier : AIDSLINE MED/97265487; The strains of HIV-1 that have caused the worldwide pandemic of acquired immunodeficiency syndrome (AIDS) have been designated as group M viruses. A group of HIV-1 viruses that also cause AIDS but that are characterized by extensive genetic divergence from group M strains have been identified recently and classified a
Surveillance for penicillin-nonsusceptible Streptococcus pneumoniae--New York City, 1995.: MMWR Morb Mortal Wkly Rep. 1997 Apr 11;46(14):297-9. Unique Identifier : AIDSLINE MED/97268930; Streptococcus pneumoniae has become a leading cause of bacteremia, pneumonia, meningitis, and otitis media in the United States . Persons at increased risk include young children, immunocompromised persons, and the elderly. Until 1987, S. pneumoniae was uniformly susceptible to penicill
AIDS rates.: MMWR Morb Mortal Wkly Rep. 1997 Apr 18;46(15):333-4. Unique Identifier : AIDSLINE MED/97268929; The following map provides the annual rates of acquired immunodeficiency syndrome (AIDS) per 100,000 population, by state of residence from January through December 1996. The accompanying table lists the metropolitan areas with the 50 highest annual rates of AIDS per 100,000 population.
Thymidine in the micromolar range promotes rejoining of UVC-induced DNA strand breaks and prevents azidothymidine from inhibiting the rejoining in quiescent human lymphocytes.: Mutat Res. 1997 Mar 12;383(2):143-53. Unique Identifier : AIDSLINE MED/97243483; Munch-Petersen B; Department of Life Sciences and Chemistry, Roskilde University,; Denmark. bmp@virgil.ruc.dk; The effect and inter-individual variation in the effect of exogenously added deoxynucleosides (2 x 10(-6) M) on rejoining of UVC-induced DNA strand breaks was examined in quiescent human lymphocytes from 25 healthy persons. Thymidine at concentrations below 2 x 10(-6) M, effectively and with statistically extreme sign
Taste and smell. Neglected senses that contribute to the malnutrition of AIDS.: N C Med J. 1997 Mar-Apr;58(2):100-4. Unique Identifier : AIDSLINE MED/97243219; Heald AE; Schiffman SS; Division of Infectious Diseases, Duke University Medical Center,; Durham 27710, USA.; Taste and smell loss (due to medications, oral pathology such as candidiasis, and peripheral or central nervous system disease) are well documented in HIV-infected people. These chemosensory abnormalities can impair food intake and contribute to wasting. An understanding of the how medications affect the senses of tas
Brain biopsy for HIV-infected patients with intracranial lesions.: N C Med J. 1997 Mar-Apr;58(2):106-9. Unique Identifier : AIDSLINE MED/97243220; Heald AE; Division of Infectious Diseases, Duke University Medical Center,; Durham 27710, USA.
Remembering Ron. A glimpse into the heart of doctoring.: N C Med J. 1997 Mar-Apr;58(2):110-2. Unique Identifier : AIDSLINE MED/97243221; Porter WG; Department of Medicine, Carolinas Medical Center, Charlotte 28232,; USA.
Primary medical care of the gay or lesbian patient.: N C Med J. 1997 Mar-Apr;58(2):92-6. Unique Identifier : AIDSLINE MED/97243217; Rankow EJ; Duke's Comprehensive Cancer Center, DUMC, Durham 27710, USA.
gp120, a human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats.: Neuroscience. 1997 Jan;76(2):397-409. Unique Identifier : AIDSLINE MED/97167707; Barks JD; Liu XH; Sun R; Silverstein FS; Department of Pediatrics, University of Michigan, Ann Arbor; 48109-0646, USA.; Recent data suggest that gp120, a human immunodeficiency virus-1 HIV-1) coat glycoprotein that is secreted by HIV-infected cells, is neurotoxic, and that this toxicity is mediated, at least in part, by activation of N-methyl-D-aspartate-type excitatory amino acid receptors. To test this hypothesis in vivo, we examined
Haemolytic-uraemic syndrome in a patient infected by HIV [letter]: Nephrol Dial Transplant. 1997 Feb;12(2):362-3. Unique Identifier : AIDSLINE MED/97206194; Benitez M; Boto A; Colchero J; Fernandez-Giron F; Rodriguez P; Paralle M; Pujol E
Consequences, cultural factors, detection, and prevention of HIV/AIDS in sub-Saharan Africa [editorial]: Obstet Gynecol Surv. 1997 Jan;52(1):1-3. Unique Identifier : AIDSLINE MED/97147332; Verkuyl DA
Anogenital papillomavirus infection and neoplasia in immunodeficient women.: Obstet Gynecol Clin North Am. 1996 Dec;23(4):861-93. Unique Identifier : AIDSLINE MED/97143768; Wright TC Jr; Sun XW; Department of Pathology, College of Physicians and Surgeons of; Columbia University, New York, New York, USA.; This article reviews the impact of infection with human immunodeficiency virus (HIV) on HPV infections and HPV-associated lesions of the female anogenital tract. Studies investigating HPV infections in HIV-seropositive women are presented as well as the possibility that HIV can influence HPV expression directly throug
HPV infection and disease in men.: Obstet Gynecol Clin North Am. 1996 Dec;23(4):895-916. Unique Identifier : AIDSLINE MED/97143769; Palefsky JM; Barrasso R; Department of Laboratory Medicine, University of California, San; Francisco, USA.; Penile HPV infection and disease are very common in sexually active men, and may be manifest in many forms. Treatment of clinically detectable lesions is advisable not only to relieve symptoms but also to prevent the spread of HPV infection to new sexual partners. Treatment of subclinical disease is more controversial
Sicca syndrome in patients infected with the human immunodeficiency virus [published erratum appears in Ophthalmology 1996 Feb;103(2):204]: Ophthalmology. 1995 Sep;102(9):1319-24. Unique Identifier : AIDSLINE MED/97252229; Geier SA; Libera S; Klauss V; Goebel FD; Augenklinik im Universitatsklinikum Rudolf Virchow, Alexander von; Humboldt Universitat zu Berlin, Germany.; PURPOSE: To investigate an association of the severity of the human immunodeficiency virus (HIV) disease with decreased tear production in a controlled setting. PATIENTS AND METHODS: Seventy-two patients (144 eyes) and 30 age- and sex-matched control subjects (60 eyes) were studied prospectively. Tear production was m
Safety and immunogenicity of three doses of a five-valent pneumococcal conjugate vaccine in children younger than two years with and without human immunodeficiency virus infection.: Pediatrics. 1997 Apr;99(4):575-80. Unique Identifier : AIDSLINE MED/97247173; King JC Jr; Vink PE; Farley JJ; Smilie M; Parks M; Lichenstein R; Department of Pediatrics, University of Maryland at Baltimore, School; of Medicine 21201, USA.; OBJECTIVE: To assess the safety and immunogenicity of three doses of a five-valent (types 6B, 23F, 14, 18C, and 19F) pneumococcal conjugate vaccine (PCV) among children younger than 2 years who are and are not infected with human immunodeficiency virus (HIV). METHODS: A convenience sample of 18 HIV-infected children 2
The ZiN/POZ domain of ZF5 is required for both transcriptional activation and repression.: Nucleic Acids Res. 1997 Mar 15;25(6):1108-16. Unique Identifier : AIDSLINE MED/97248676; Kaplan J; Calame K; Department of Microbiology, Columbia University College of Physicians; and Surgeons, New York, NY 10032, USA.; ZF5 is a ubiquitously expressed protein originally identified by its ability to bind and repress the murine c-myc promoter. It contains five C-terminal zinc fingers and a conserved N-terminal ZiN/POZ domain. This motif, found in a growing number of zinc finger proteins, can inhibit DNA binding and mediate dimerization
Characterization of nuclear proteins that bind to the regulatory TGATTGGC motif in the human immunodeficiency virus type 1 long terminal repeat.: Nucleic Acids Res. 1997 Mar 15;25(6):1177-84. Unique Identifier : AIDSLINE MED/97248686; Schwartz C; Canonne-Hergaux F; Aunis D; Schaeffer E; Unite 338 INSERM, Centre de Neurochimie, 5 rue Blaise Pascal, 67084; Strasbourg Cedex, France.; We have recently elucidated the nature and function of transcription factors present in Jurkat, glial and neuronal cells that interact with modulatory region B, the nuclear receptor responsive element, in the long terminal repeat of human immunodeficiency virus type 1 (HIV-1). Considering the key role that the combina
Effects of ddC and AZT on locomotion and acoustic startle. I: Acute effects in female rats.: Pharmacol Biochem Behav. 1997 Feb;56(2):221-8. Unique Identifier : AIDSLINE MED/97202559; Morse DE; Davis HD; Popke EJ; Brown KJ; O'Donoghue VA; Grunberg NE; U.S. Food and Drug Administration, Division of Antiviral Drug; Products, Rockville, MD 20857, USA.; Several synthetic nucleoside analogues, including AZT (RETROVIR), ddC (HIVID), ddI (VIDEX), and d4T (ZERIT), are cur
[European case definition of AIDS surveillance in children, revision in 1995]: Przegl Epidemiol. 1996;50(4):387-94. Unique Identifier : AIDSLINE MED/97222746; Szata W; Zaklad Epidemiologii Panstwowego Zakladu Higieny w Warszawie.
[Initial evaluation of the diagnostic usefulness of tuberculin tests among the patients of the Center of Diagnosis and Treatment of AIDS]: Przegl Epidemiol. 1996;50(4):395-400. Unique Identifier : AIDSLINE MED/97222747; Zielinski A; Cholewinska G; Wondolowska B; Bakowska E; Kopicz-Kaminska E; Burkacka E; Zalewska-Schonthaler N; Baran J; Lipniacki A; Wozny W; Horban A; Centrum Diagnostyki i Terapii AIDS w Warszawie.; Tuberculin and Candida skin tests were done on 98 HIV(+) and 42 control HIV(-) patients of AIDS Diagnosis and Therapy Center in Warsaw. Prevalence of the positive Tuberculin tests in the control group was 29% and it was not significantly different from those groups of patients HIV(+) whose CD4 cell count was higher th
[Initial assessment of the use of polymerase chain reaction (PCR) in diagnosis of tuberculosis among patients of the Center for Diagnosis and Treatment of AIDS]: Przegl Epidemiol. 1996;50(4):401-5. Unique Identifier : AIDSLINE MED/97222748; Zielinski A; Cholewinska G; Wondolowska B; Bakowska E; Kopicz-Kaminska E; Zajaczkowska J; Zalewska-Schonthaler N; Baran J; Lipniacki A; Wozny W; Horban A; Burkacka E; Centrum Diagnostyki i Terapii AIDS w Warszawie.; This initial report on the use of PCR in diagnosis of TB was based on a group of 180 patients observed in the AIDS Diagnosis and Therapy Center in Warsaw. Out of 6 patients with positive results of PCR assay for MTB, five had positive AFB smears in induced sputum or BAL, two had positive MTB cultures. Five of them wer
[Mental disorders in HIV-1 infection]: Rev Clin Esp. 1996 Nov;196(11):774-84. Unique Identifier : AIDSLINE MED/97164518; Lozano Suarez M; Padin Calo JJ; Buzon Rueda L; Servicio de Psiquiatria, Hospital Ramon y Cajal, Madrid.
[Radiotherapy in Kaposi's sarcoma: a complex palliative treatment editorial)]: Rev Clin Esp. 1996 Dec;196(12):803-5. Unique Identifier : AIDSLINE MED/97172015; Calvo Manuel FA
[Skin lesions in epidemic Kaposi's sarcoma (AIDS): local control assessment and esthetic results of a schedule of superficial radiotherapy]: Rev Clin Esp. 1996 Dec;196(12):806-10. Unique Identifier : AIDSLINE MED/97172016; Pinazo J; Ferrer C; Real E; Dualde D; Gonzalez A; Sancho R; Servicio de Radioterapia, Hospital Clinico Universitario, Valencia.; This prospective study was undertaken to evaluate the clinical response of 51 cutaneous lesions of epidemic Kaposi sarcoma in patients with AIDS (EKS/AIDS), obtained with the use of a scheme of superficial radiotherapy (3 Gy/fraction, three fractions weekly up to a total dose of 30 Gy). The mean follow-up time was 9.3
[Tuberculous hepatosplenic abscess, human immunodeficiency virus infection and multiresistant tuberculosis]: Rev Clin Esp. 1996 Dec;196(12):816-20. Unique Identifier : AIDSLINE MED/97172018; Valencia ME; Moreno V; Soriano V; Laguna F; Adrados M; Ortega A; March J; Cobo J; Gonzalez-Lahoz J; Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid.; BACKGROUND: Tuberculosis (TB) with liver and/or spleen abscess HSA) formation in HIV-positive patients is uncommon. PATIENTS AND METHODS: One hundred and thirty-seven HIV positive patients with TB were studied from January 93 to June 95. Patients with tuberculous HSA were enrolled in the study. Diagnosis was obtained
[Thrombocytopenia associated with human immunodeficiency virus infection]: Rev Clin Esp. 1996 Dec;196(12):834-45. Unique Identifier : AIDSLINE MED/97172022; Moreno Garcia M; Hospital General Penitenciario, Madrid.
[Viral load and monitoring of antiretroviral treatment]: Rev Clin Esp. 1996 Dec;196(12):872-7. Unique Identifier : AIDSLINE MED/97172029; Soriano V; Mas A; Gomez-Cano M; Villalba N; Bravo R; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III,; Madrid.
[Oral amphotericin B inefficacy in the treatment of fluconazole++ resistant oropharyngeal candidiasis in HIV-positive patients letter)]: Rev Clin Esp. 1996 Dec;196(12):878-9. Unique Identifier : AIDSLINE MED/97172030; Laguna F; Valencia E; Polo R; Moreno V; Gonzalez-Lahoz JM
[Non-Hodgkin's lymphoma with heart disease in patients with AIDS: clinical and echocardiographic aspects]: Rev Esp Cardiol. 1997 Mar;50(3):201-4. Unique Identifier : AIDSLINE MED/97243238; Castro M; Zamorano J; Roca V; Almeria C; Furio V; Crespo A; Rodriguez P; Sanchez-Harguindey L; Servicio de Medicina Interna III, Hospital Clinico San Carlos, Madrid.; We report two patients with AIDS and non-Hodgkin lymphoma evolving myocardium. Clinical findings were nonspecific, but rapid progression and cardiac dysfunction developed. An echocardiogram showed restrictive pericarditis in both cases. One of them showed mitral insufficiency because of an infiltrated and trapped post
Managed care, cost-effectiveness, and rehabilitation: the case of HIV.: Rehabil Nurs. 1997 Jan-Feb;22(1):7-13, 19. Unique Identifier : AIDSLINE MED/97265051; Montoya ID; Carlson JW; Richard AJ; Goodpastor WA; Affiliated Systems Corporation, Houston, TX 77027-6022, USA.; ASC@Phoenix.net; Because of its cost-effective approach to impairment and disability, rehabilitation therapy is uniquely positioned to assume a significant role in today s healthcare environment. As the cost of health care has become a major concern, both the government and the private insurance industry have turned toward rehabilitat
Estimating means and percentages in a complex sampling survey: application to a French national survey on sexual behaviour ACSF). Analyse des Comportements Sexuels en France.: Stat Med. 1997 Feb 28;16(4):397-423. Unique Identifier : AIDSLINE MED/97197469; Warszawski J; Messiah A; Lellouch J; Meyer L; Deville JC; INSERM U292, Hopital, de Bicetre, Le Kremlin-Bicetre, France.; Two-phase stratification sampling with unequal selection probabilities is a relatively cost-efficient strategy to address problems on a nationwide basis and to perform comparative analyses of specific subgroups. This was the case with the ACSF survey. Specific procedures to estimate the variances of unbiased estimator
Conditional power calculations for early acceptance of H0 embedded in sequential tests.: Stat Med. 1997 Feb 28;16(4):465-77. Unique Identifier : AIDSLINE MED/97197473; Betensky RA; Department of Biostatistics, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; For ethical and efficiency concerns one often wishes to design a clinical trial to stop early if there is a strong treatment effect or if there is strong evidence of no treatment effect. There is a large literature to address the design of sequential trials for detecting treatment differences. There has been less atte
[Regulation of the immune response: the TH1/TH2 concept]: Schweiz Med Wochenschr. 1997 Mar 1;127(9):341-8. Unique Identifier : AIDSLINE MED/97237641; Pichler WJ; Institut fur Immunologie und Allergologie, Inselspital, Bern.; The immune system has different possible ways of reacting to an antigen. The choice of an appropriate immune response is determined by the manner of antigen presentation, the amount of antigen, the localization of antigen uptake, the type of antigen presenting cell, the genetic predisposition of the individual and the
AIDS research. Program funding, Italian style [news]: Science. 1997 Apr 11;276(5310):191. Unique Identifier : AIDSLINE MED/97268584; Biggin S
Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells.: Science. 1997 Apr 11;276(5310):273-6. Unique Identifier : AIDSLINE MED/97248643; Carroll RG; Riley JL; Levine BL; Feng Y; Kaushal S; Ritchey DW; Bernstein W; Weislow OS; Brown CR; Berger EA; June CH; St. Louis DC; Henry M. Jackson Foundation for the Advancement of Military Medicine,; Rockville, MD 20850, USA.; Activation of CD4(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-1. Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line-tropic isolates
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.: Science. 1997 Apr 11;276(5310):276-9. Unique Identifier : AIDSLINE MED/97248644; Simmons G; Clapham PR; Picard L; Offord RE; Rosenkilde MM; Schwartz TW; Buser R; Wells TNC; Proudfoot AE; Virology Group, Chester Beatty Laboratories, Institute of Cancer; Research, 237 Fulham Road, London SW3 6JB, UK.; The chemokine receptors CXCR4 and CCR5 have recently been shown to act as coreceptors, in concert with CD4, for human immunodeficiency virus-type 1 (HIV-1) infection. RANTES and other chemokines that interact with CCR5 and block infection of peripheral blood mononuclear cell cultures inhibit infection of primary macro
Salmonella as a cause of bacteremia and subdural empyema in a patient with HIV infection.: Southeast Asian J Trop Med Public Health. 1996 Mar;27(1):196-9. Unique Identifier : AIDSLINE MED/97183294; Kanchanapongkul J; Aroonsakul K; Department of Medicine, Chon Buri Hospital, Thailand.
Frequency and risk of HIV infection among men attending a clinic for STD in Chiang Mai, Thailand.: Southeast Asian J Trop Med Public Health. 1996 Mar;27(1):96-101. Unique Identifier : AIDSLINE MED/97183275; Siraprapasiri T; Foy HM; Kreiss JK; Pruithitada N; Thongtub W; Division of Epidemiology, Ministry of Public health, Nonthaburi,; Thailand.; A prospective study was conducted in the Chiang Mai Sexually Transmitted Diseases Clinic to determine the frequency of HIV seroconversion among men following high risk sexual contacts and to establish risk factors for HIV infection. HIV antibodies were detected in 26 out of 150 men on the initial recruitment with a se
Sexual transmission of hepatitis B in Mwanza, Tanzania.: Sex Transm Dis. 1997 Mar;24(3):121-6. Unique Identifier : AIDSLINE MED/97227552; Jacobs B; Mayaud P; Changalucha J; Todd J; Ka-Gina G; Grosskurth H; Berege ZA; LIVOS Project, Mwanza, Tanzania.; BACKGROUND: Hepatitis B virus (HBV) is endemic and poses a grave public health problem in Africa where it is mainly transmitted from mother to baby or during childhood. Sexual transmission has also been suggested to play a role in East Africa, but this has never been properly demonstrated. Additional preventive strate
Acceptability and compliance with daily injections of procaine penicillin in the outpatient treatment of syphilis-treponemal infection.: Sex Transm Dis. 1997 Mar;24(3):127-30. Unique Identifier : AIDSLINE MED/97227553; Crowe G; Theodore C; Forster GE; Goh BT; Ambrose King Centre, Department of Genito-Urinary Medicine, Royal; London Hospital, Whitechapel.; BACKGROUND: In the United Kingdom , it is recommended that syphilis should be treated with intramuscular daily procaine penicillin with or without oral probenecid for 8 to 21 days. However, it has been argued that this regimen would be unacceptable to patients in terms of daily attendan
Immunologic effects of cocaine in prenatally exposed rats and mice.: Toxicol Lett. 1997 Mar 14;91(1):47-55. Unique Identifier : AIDSLINE MED/97250430; Bohn AA; Forsyth CS; Kerkvliet NI; Frank AA; Department of Pathology, Colorado State University, Fort Collins; 80523, USA. abohn@vines.colostate.edu; The immunotoxicity of prenatal cocaine exposure was investigated using Sprague-Dawley rats and C57B1/6 mice. Pregnant animals were injected twice a day with cocaine or saline from gestation day 5 until the day before parturition. The immune system of the rat offspring was evaluated at 8 weeks of age by measuring the a
Human parvovirus B19 and blood products.: Vox Sang. 1997;72(1):1-10. Unique Identifier : AIDSLINE MED/97183359; Prowse C; Ludlam CA; Yap PL; National Science Laboratory, Scottish National Blood Transfusion; Service, Edinburgh, UK.; BACKGROUND AND OBJECTIVES: Human B19 parvovirus (B19), identified in 1975, was only recognised as the causative agent of fifth disease in 1983. The incidence of viraemia is low, around 1 in 1,000, but is sufficient to ensure that most plasma pools for fractionation contain some virus. While infection usually occurs in
Sensitivity and specificity of standard and rapid HIV-antibody tests evaluated by seroconversion and non-seroconversion low-titre panels.: Vox Sang. 1997;72(1):11-5. Unique Identifier : AIDSLINE MED/97183360; Kuun E; Brashaw M; Heyns AD; South African Blood Transfusion Service, Johannesburg, South Africa.; BACKGROUND AND OBJECTIVES: The aim of this study is to compare the relative sensitivity and specificity of commercial HIV-antibody assays using seroconversion, non-seroconversion panels, and negative blood donor samples. MATERIALS AND METHODS: We evaluated the sensitivity of five standard ELISA HIV-antibody assays: Vi
[Cellular and humoral functions in acute pancreatitis]: Wien Med Wochenschr. 1997;147(1):10-3. Unique Identifier : AIDSLINE MED/97202667; Schulz HU; Schmidt D; Kunz D; Pross M; Gerber A; Weiss G; Sokolowski A; Struy H; Lippert H; Klinik fur Chirurgie, Otto von Guericke-Universitat Magdeburg,; Deutschland.; Infectious complications are the leading cause of death in acute pancreatitis. Individual factors of immune defence could be of significance, whether or not a patient develops a severe course with infectious complications. In a prospective 5-year trial including 72 patients, we investigated 29 cellular and humoral mar
Induction of apoptosis in murine clonal osteoblasts expressed by human T-cell leukemia virus type I tax by NF-kappa B and TNF-alpha.: J Bone Miner Res. 1996 Feb;11(2):200-10. Unique Identifier : AIDSLINE MED/96419586; Kitajima I; Nakajima T; Imamura T; Takasaki I; Kawahara K; Okano T; Tokioka T; Soejima Y; Abeyama K; Maruyama I; Department of Laboratory and Molecular Medicine, University of; Kagoshima, Japan.; We investigated the effects of various cytokines in the presence of human T-cell leukemia virus type I (HTLV-I) tax protein in murine clonal osteoblasts, MC3T3-E1 cells. Skeletal remodeling by osteoclasts and osteoblasts is coordinated by cytokines, which are activated by HTLV-I tax protein via nuclear factor-kappa B
[Screening tools for cognitive deterioration in HIV infections]: Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1997 Jan-Feb;25(1):45-9. Unique Identifier : AIDSLINE MED/97241286; Ayuso Mateos JL; Herran A; Universidad de Cantabria, Unidad de Investigacion, Hospital; Universitario Marques de Valdecilla, Santander.; The development of cognitive impairment is a frequent complication over the course of HIV infection that can be present in over 20% of the patients in advanced stages of the illness. There is a clear need for screening instruments that allows the clinician to identify easily this condition. This paper reviews the thre
Do young women in tropical regions constitute a recognized social category?: Acta Trop. 1996 Dec 30;62(4):201-7. Unique Identifier : AIDSLINE MED/97180229; Ahlberg BM; Department of International Health and Social Medicine, Karolinska; Institutet, Stockholm, Sweden.; In most tropical regions there is little organized health care for young women, yet their household roles within contexts of worsening socio-economic situations create special health problems. In the area of sexual and reproductive health, the onset of reproductive roles does not entitle the young women to either mate
Providing accessible health care for adolescents with sexually transmitted disease.: Acta Trop. 1996 Dec 30;62(4):209-16. Unique Identifier : AIDSLINE MED/97180230; Brabin L; Women's Health Programme, Liverpool School of Tropical Medicine, UK.; Provision of sexually transmitted disease (STD) care for sexually active adolescents has been neglected in developing countries, although this is changing. Available evidence indicates that STDs are a serious problem among adolescents (10-19 years), especially in rural areas where services are limited for any age grou
Thrombocytopenia in HIV-infected and uninfected hemophiliacs. Multicenter Hemophilia Cohort study.: Am J Hematol. 1997 Apr;54(4):296-300. Unique Identifier : AIDSLINE MED/97246446; Ehmann WC; Rabkin CS; Eyster ME; Goedert JJ; Department of Medicine, Pennsylvania State University College of; Medicine, Hershey 17033, USA.; To determine the incidence and prognostic significance of thrombocytopenia among hemophiliacs, we analyzed clinical and hematologic data from the Multicenter Hemophilia Cohort study. Nineteen percent of HIV-infected subjects had thrombocytopenia platelet count of
Clonal integration and expression of human T-cell lymphotropic virus type I in carriers detected by polymerase chain reaction and inverse PCR.: Am J Hematol. 1997 Apr;54(4):306-12. Unique Identifier : AIDSLINE MED/97246448; Ohshima K; Mukai Y; Shiraki H; Suzumiya J; Tashiro K; Kikuchi M; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; Adult T-cell leukemia (ATL) is a neoplasm of mature helper (CD4) T lymphocytes, and human T-cell lymphotropic virus type-I HTLV-I) has been suggested to be the causative virus of ATL. HTLV-I integrates its proviruses into random sites in host chromosomal DNA. Clonal integration has been observed in patients with ATL,
Aggressive natural killer cell lymphoproliferative disorder associated with Epstein-Barr viral RNA.: Am J Hematol. 1997 Apr;54(4):314-20. Unique Identifier : AIDSLINE MED/97246450; Hirose Y; Masaki Y; Yoshioka R; Takiguchi T; Department of Internal Medicine, Kanazawa Medical University,; Kahoku-gun, Ishikawa, Japan.; Lymphoproliferative disorder of natural killer cells is a heterogeneous disorder, and an association with Epstein-Barr virus (EBV) is suggested in some cases. A Japanese male presenting with recurrent nasopharyngeal problems developed fever, generalized lymphadenopathy, and hepatosplenomegaly. Separated cells from lym
Immune complex glomerulonephritis in patients coinfected with human immunodeficiency virus and hepatitis C virus.: Am J Kidney Dis. 1997 Apr;29(4):514-25. Unique Identifier : AIDSLINE MED/97254629; Stokes MB; Chawla H; Brody RI; Kumar A; Gertner R; Goldfarb DS; Gallo G; Department of Pathology, New York University Medical Center, New York,; NY 10016, USA.; Human immunodeficiency virus-associated nephropathy (HIVAN), characterized by heavy proteinuria, rapidly progressive renal failure, collapsing glomerulopathy, and tubulointerstitial abnormalities, is the most common finding in HIV-infected patients undergoing a renal biopsy and predominantly affects blacks. We descr
Uremia therapy in patients with end-stage renal disease and human immunodeficiency virus infection: has the outcome changed in the 1990s?: Am J Kidney Dis. 1997 Apr;29(4):549-52. Unique Identifier : AIDSLINE MED/97254633; Ifudu O; Mayers JD; Matthew JJ; Macey LJ; Brezsnyak W; Reydel C; McClendon E; Surgrue T; Rao TK; Friedman EA; Department of Medicine, State University of New York Health Science; Center, Brooklyn 11203, USA.; We conducted a cross-sectional survey to determine the relative course of patients with end-stage renal disease (ESRD) and human immunodeficiency virus (HIV) infection sustained on maintenance hemodialysis. All 34 patients with ESRD and HIV infection receiving hemodialysis in one hospital-based and three community-bas
Clinical response to prolonged corticosteroids in a patient with human immunodeficiency virus-associated nephropathy.: Am J Kidney Dis. 1997 Apr;29(4):624-6. Unique Identifier : AIDSLINE MED/97254645; Watterson MK; Detwiler RK; Bolin P Jr; Department of Medicine, East Carolina University, Greenville, NC; 27858, USA.; Human immunodeficiency virus-associated nephropathy (HIVAN) is characterized by massive proteinuria with rapidly progressive renal failure. We report an adult with HIV infection who developed nephrotic-range proteinuria and acute renal failure requiring hemodialysis. Renal biopsy findings were consistent with HIVAN, e
Behcet's-like syndrome associated with idiopathic CD4+ T-lymphocytopenia, opportunistic infections, and a large population of TCR alpha beta+ CD4- CD8- T cells.: Am J Med Sci. 1997 Apr;313(4):236-8. Unique Identifier : AIDSLINE MED/97253916; Venzor J; Hua Q; Bressler RB; Miranda CH; Huston DP; Department of Medicine, Baylor College of Medicine, Houston, Texas; 77030, USA.; Herein we report a patient with Behcet s like syndrome, idiopathic CD4+ T-lymphocytopenia, opportunistic infections, and a large polyclonal population of TCR alpha beta + CD4- CD8- T cells. Microfluorimetric analysis of peripheral blood mononuclear cells revealed CD4+ T-cell counts of 10 +/- 5/mm3. The CD3+ T cells we
Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS.: Am J Med Sci. 1997 Apr;313(4):244-6. Unique Identifier : AIDSLINE MED/97253918; Akula SK; Rege AB; Dreisbach AW; Dejace PM; Lertora JJ; Department of Veterans Affairs Medical Center, New Orleans, LA 70146,; USA.; Valproic acid is an anticonvulsant drug known to inhibit the glucuronidation of zidovudine ( AZT ) in human liver microsomes. Zidovudine is metabolized by glucuronidation to the inactive 5 -glucuronide with a short plasma half-life (1.0 +/- 0.2 hour). T
'Abusive patient': a case of mistaken identity [letter; comment]: Am J Nurs. 1997 Apr;97(4):20. Unique Identifier : AIDSLINE MED/97257420; Cunningham JH
Anatomic dissociation between HIV-1 and its endogenous inhibitor in mucosal tissues.: Am J Pathol. 1997 Apr;150(4):1275-84. Unique Identifier : AIDSLINE MED/97249079; Wahl SM; Worley P; Jin W; McNeely TB; Eisenberg S; Fasching C; Orenstein JM; Janoff EN; Laboratory of Immunology, National Institute of Dental Research,; Bethesda, MD 20892-4352, USA.; The rarity of oral transmission of human immunodeficiency virus HIV)-1 by saliva suggests the absence of HIV-1 in the oral cavity and/or the presence of viral inhibitory molecules. We analyzed salivary gland tissues from 55 individuals with acquired immune deficiency syndrome (AIDS) for the presence of HIV-1 by in sit
Identification of an Enterocytozoon bieneusi-like microsporidian parasite in simian-immunodeficiency-virus-inoculated macaques with hepatobiliary disease.: Am J Pathol. 1997 Apr;150(4):1395-405. Unique Identifier : AIDSLINE MED/97249090; Mansfield KG; Carville A; Shvetz D; MacKey J; Tzipori S; Lackner AA; New England Regional Primate Research Center, Harvard Medical School,; Southborough, MA 01772, USA.; Enterocytozoon bieneusi is a common opportunistic pathogen of human patients with acquired immune deficiency syndrome (AIDS) causing significant morbidity and mortality. In a retrospective analysis utilizing conventional histochemical techniques, in situ hybridization, polymerase chain reaction, and ultrastructural ex
HIV/AIDS surveillance in Italy: the potential misinterpretation of time trends [letter]: Am J Public Health. 1997 Mar;87(3):469-70. Unique Identifier : AIDSLINE MED/97250877; Pezzotti P; Piovesan C; Rezza G; Ferraro P
Oral sex, crack smoking, and HIV infection among female sex workers who do not inject drugs [letter]: Am J Public Health. 1997 Mar;87(3):470. Unique Identifier : AIDSLINE MED/97250878; Wallace JI; Porter J; Weiner A; Steinberg A
Infection Control in Anesthesia. Proceedings of a symposium. November 1994.: Anaesth Intensive Care. 1996 Apr;24(2):149-96. Unique Identifier : AIDSLINE MED/97013015
Screening for HIV: ratios, risks and rationality.: Anaesth Intensive Care. 1996 Apr;24(2):191-6. Unique Identifier : AIDSLINE MED/97013024; Jones ME; School of Medicine , Flinders University, Adelaide, Australia.; Screening patients or healthcare workers for Human Immunodeficiency Virus is unlikely to be cost-effective if the benefit is seen only as the prevention of infection of one group by the other within the healthcare institution. Overwhelmingly, the benefit of screening comes from interrupting the chains of infection wit
[Acute respiratory failure secondary to Pneumocystis carinii pneumonia in children]: An Esp Pediatr. 1996 Dec;45(6):570-4. Unique Identifier : AIDSLINE MED/97164429; Martinez Marin MI; de la Mota Ybancos JL; Romero Garcia J; Milano Manso G; Perez Ruiz E; Calvo Macias C; Martinez Valverde A; Departamento de Pediatria, Hospital Materno Infantil, Hospital; Regional, Malaga.; OBJECTIVE: The objective of this study was to ascertain the clinical and epidemiological characteristics of Pneumocystis carinii pneumonia (PCP) cases admitted to the Pediatric Intensive Care Unit (PICU). PATIENTS AND METHODS: A retrospective study was carried out on the 8 PCP cases admitted to the PICU from July 1991
Symptomatic human immunodeficiency virus (HIV) infection in Papua New Guinea.: Aust N Z J Med. 1996 Dec;26(6):783-8. Unique Identifier : AIDSLINE MED/97180332; Seaton RA; Wembri JP; Armstrong P; Ombiga J; Naraqi S; Kevau I; Department of Clinical Sciences, Medical Faculty, University of Papua; New Guinea.; BACKGROUND: Human Immunodeficiency Virus (HIV) infection was first detected in Papua New Guinea (PNG) in 1987. By August 1995 a total of 323 persons had been diagnosed as HIV antibody positive nationwide and seroprevalence rates wer
Human recombinant interferon alpha-2a plus 3'-azido-3'-deoxythymidine. Synergistic growth inhibition with evidence of impaired DNA repair in human colon adenocarcinoma cells.: Biochem Pharmacol. 1997 Feb 21;53(4):571-80. Unique Identifier : AIDSLINE MED/97259289; Darnowski JW; Davol PA; Goulette FA; Department of Medicine, Brown University, Rhode Island Hospital,; Providence 02903, USA.; We reported that 3 -azidothymidine-3 -deoxythymidine ( AZT ) plus 5-fluorouracil or methotrexate produces additive cytotoxicity in HCT-8 cells: a reflection of increased AZT metabolism when de novo thymidylate (dTMP) synthesis was inhibited. We now repo
Influence of HIV-infection risk on resident physicians.: Acad Med. 1996 Jun;71(6):684-6. Unique Identifier : AIDSLINE MED/97270979; Ritota PC; Quirke TE; Byer A; Temple University School of Medicine, Philadelphia, PA, USA.; PURPOSE: To determine the influence of the risk of contracting the human immunodeficiency virus (HIV) on the attitudes and behavior of resident physicians. METHOD: A 15-item questionnaire was sent in January 1994 to the 268 residents in the major specialty training programs at the three clinical campuses of the Univer
Lymphocyte immunotherapy (LI) increases serum levels of progesterone induced blocking factor (PIBF).: Am J Reprod Immunol. 1997 Jan;37(1):17-20. Unique Identifier : AIDSLINE MED/97205675; Check JH; Arwitz M; Gross J; Peymer M; Szekeres-Bartho J; University of Medicine and Dentistry of New Jersey, Robert Wood; Johnson Medical School at Camden, USA.; PROBLEM: To determine if allogenic stimulation from leukocyte immunization (LI) can increase the production of an immunomodulatory protein called progesterone induced blocking factor (PIBF) by CD8+ T-lymphocytes. METHODS: The study group consisted of 35 women, 29 who failed to conceive after repeated embryo transfers
Oral ganciclovir for cytomegalovirus retinitis in patients with AIDS: results of two randomized studies.: AIDS. 1996 Dec;10 Suppl 4:S13-8. Unique Identifier : AIDSLINE MED/97264193; Squires KE; Outpatient AIDS Clinic, University of Alabama at Birmingham 35294,; USA.; OBJECTIVE: To determine the relative effectiveness of an oral formulation compared to a standard intravenous regimen of ganciclovir in preventing the progression of cytomegalovirus CMV ) retinitis in patients with AIDS. DESIGN
Funduscopy versus photographic assessment of cytomegalovirus retinitis progression: a clinician's perspective.: AIDS. 1996 Dec;10 Suppl 4:S19-23. Unique Identifier : AIDSLINE MED/97264194; Migdal C; Western Eye Hospital, London, UK.; OBJECTIVE: Funduscopy was compared with retinal photographs in the documentation of progression of cytomegalovirus ( CMV ) retinitis. SETTING: Clinical centres provided oral ganciclovir maintenance therapy for AIDS patients wit
Ganciclovir evaluation in AIDS patients with cytomegalovirus retinitis: a European study of treatment patterns and resource utilization.: AIDS. 1996 Dec;10 Suppl 4:S25-30. Unique Identifier : AIDSLINE MED/97264195; Hardens M; OBJECTIVE: To describe the treatment patterns for intravenous ganciclovir induction and maintenance therapy in AIDS patients with cytomegalovirus ( CMV ) retinitis in five European countries and to investigate the anticipated i
Pharmacokinetics of oral ganciclovir capsules in HIV-infected persons.: AIDS. 1996 Dec;10 Suppl 4:S3-6. Unique Identifier : AIDSLINE MED/97264191; Griffy KG; Roche Bioscience, Palo Alto, California, USA.; OBJECTIVES: To delineate the pharmacokinetic profile of the oral capsule formulation of ganciclovir, and determine whether oral ganciclovir has any pharmacokinetics interactions with zidovudine, didanosine or probenecid. MEASUREMENTS: Serum and urine concentrations of ganciclovir, zidovudine and didanosine were measur
Cytomegalovirus retinitis in AIDS patients: a comparative study of intravenous and oral ganciclovir as maintenance therapy.: AIDS. 1996 Dec;10 Suppl 4:S7-11. Unique Identifier : AIDSLINE MED/97264192; Danner SA; Matheron S; Division of Infectious Diseases, University of Amsterdam, The; Netherlands.; OBJECTIVES: To compare the safety and efficacy or oral ganciclovir with intravenous ganciclovir for the maintenance therapy of cytomegalovirus ( CMV ) retinitis in AIDS patients. DESIGN: Multicenter, randomized, open-label stud
Interference of HIV-1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor-alpha in human glial cells.: AIDS. 1997 Jan;11(1):F1-7. Unique Identifier : AIDSLINE MED/97264196; Richard A; Robichaud G; Lapointe R; Bourgoin S; Darveau A; Poulin L; Infectious Diseases, CHUL Research Centre, Quebec, Canada.; OBJECTIVE: The HIV-1 nef gene product, thought to interact with mediators of cell signalling, is overexpressed during the restricted HIV-1 infection of human astrocytes. This infection can be reactivated following exposure to tumour necrosis factor TNF)-alpha. We examined the possibility that Nef alters the TNF-alpha-
CD8+ T-cell-mediated suppression of HIV replication in the first year of life: association with lower viral load and favorable early survival.: AIDS. 1997 Jan;11(1):F9-13. Unique Identifier : AIDSLINE MED/97264197; Pollack H; Zhan MX; Safrit JT; Chen SH; Rochford G; Tao PZ; Koup R; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical-Bellevue; Hospital Center, NY 10016, USA.; OBJECTIVE AND DESIGN: To study the role and development of non-cytotoxic CD8+ T-cell-mediated suppression of HIV replication in early perinatal HIV infection in a prospective study of vertically infected infants. CD8 T-cell-mediated HIV suppression was measured several times during the first year of life and correlate
Diagnosis of central nervous system complications in HIV-infected patients: cerebrospinal fluid analysis by the polymerase chain reaction [editorial]: AIDS. 1997 Jan;11(1):1-17. Unique Identifier : AIDSLINE MED/97264198; Cinque P; Scarpellini P; Vago L; Linde A; Lazzarin A
HIV infection and vaginal douching in central Africa.: AIDS. 1997 Jan;11(1):101-6. Unique Identifier : AIDSLINE MED/97264210; Gresenguet G; Kreiss JK; Chapko MK; Hillier SL; Weiss NS; Department of Epidemiology, University of Washington, Seattle, USA.; OBJECTIVE: To determine whether vaginal douching is associated with HIV infection. METHODS: A total of 397 female patients who attended the referral clinic for sexually transmitted diseases in Bangui, Central African Republic , from August 1994 to February 1995, were
Adherence to tuberculosis preventive therapy among HIV-infected persons in Chiang Rai, Thailand.: AIDS. 1997 Jan;11(1):107-12. Unique Identifier : AIDSLINE MED/97264211; Ngamvithayapong J; Uthaivoravit W; Yanai H; Akarasewi P; Sawanpanyalert P; College of Public Health, Chulalongkorn University, Bangkok, Thailand.; OBJECTIVE: To determine the level of and reasons associated with adherence to tuberculosis preventive therapy among asymptomatic HIV-infected individuals in northern Thailand . DESIGN: A prospective cohort study with a 9-month follow-up. METHODS: A total of 412 HIV-infected person
Why do HIV-1 subtypes segregate among persons with different risk behaviors in South Africa and Thailand? [editorial; comment]: AIDS. 1997 Jan;11(1):113-6. Unique Identifier : AIDSLINE MED/97264212; Mastro TD; Kunanusont C; Dondero TJ; Wasi C
High prevalence of HIV-specific immunity in seronegative Ethiopian immigrants in Israel [letter]: AIDS. 1997 Jan;11(1):117-8. Unique Identifier : AIDSLINE MED/97264213; Bar-Yehuda S; Weisman Z; Kalinkovich A; Vonsover A; Zlotnikov S; Jehuda-Cohen T; Bentwich Z
Toxoplasmosis in HIV-positive women: seroprevalence and the role of prophylaxis in preventing disease [letter; comment]: AIDS. 1997 Jan;11(1):119-20. Unique Identifier : AIDSLINE MED/97264214; Ruiz R; Cu-Uvin S; Fiore T; Flanigan TP
Rhodococcus equi infections: antibiotic therapy and relapses [letter; comment]: AIDS. 1997 Jan;11(1):120-1. Unique Identifier : AIDSLINE MED/97264215; Giacometti A; Cirioni O; Burzacchini F; Del Prete MS; Balducci M; al Natour I; Scalise G
HIV-related vasculitis: clinical presentation and therapeutic approach on six patients [letter]: AIDS. 1997 Jan;11(1):121-3. Unique Identifier : AIDSLINE MED/97264216; Gisselbrecht M; Cohen P; Lortholary O; Jarrousse B; Gayraud M; Gherardi R; Baudrimont M; Guillevin L
Outcome in a cohort of long-term non-progressors in Madrid: virological and immunological findings [letter]: AIDS. 1997 Jan;11(1):123-4. Unique Identifier : AIDSLINE MED/97264217; Soriano V; Martin R; del Romero J; Heredia A; Dietrich U; Mas A; Adrados M; Martinez P; Hewlett I; Gonzalez-Lahoz J
Detection of HIV infection during window period using polyclonal B-cell activation test [letter]: AIDS. 1997 Jan;11(1):124-5. Unique Identifier : AIDSLINE MED/97264218; Jehuda-Cohen T; Mumo JM; Bwayo JJ; Pezzella M
Comparison of branched DNA and reverse transcriptase polymerase chain reaction for quantifying six different HIV-1 subtypes in plasma [letter]: AIDS. 1997 Jan;11(1):126-7. Unique Identifier : AIDSLINE MED/97264219; Dunne AL; Crowe SM
Corrected prevalence of Kaposi's sarcoma (KS)-associated herpesvirus infection prior to onset of KS [letter]: AIDS. 1997 Jan;11(1):127-8. Unique Identifier : AIDSLINE MED/97264220; Parry JP; Moore PS
Prevalence of a V2 epitope in clade B primary isolates and its recognition by sera from HIV-1-infected individuals [letter]: AIDS. 1997 Jan;11(1):128-30. Unique Identifier : AIDSLINE MED/97264221; Israel ZR; Gorny MK; Palmer C; McKeating JA; Zolla-Pazner S
A role for gamma delta T lymphocytes in the development of advanced clinical forms of tuberculosis in HIV-infected patients [letter]: AIDS. 1997 Jan;11(1):130-2. Unique Identifier : AIDSLINE MED/97264222; Duarte R; Ramirez R; Kindelan JM; Carracedo J; Sanchez-Guijo P
T-cell recognition of HIV antigens in HIV-seroreverted persons [letter]: AIDS. 1997 Jan;11(1):132-3. Unique Identifier : AIDSLINE MED/97264223; Ranki A; Suni J; Blazevic V; Holmstrom P; Mattinen S; Krohn K; Valle SL
Aspergilloma formation in a pneumatocele associated with Pneumocystis carinii pneumonia [letter]: AIDS. 1997 Jan;11(1):135-7. Unique Identifier : AIDSLINE MED/97264225; Schouwink JH; Weigel HM; Blaauwgeers JL; Schreurs AJ
Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HIV syndrome.: AIDS. 1997 Jan;11(1):19-26. Unique Identifier : AIDSLINE MED/97264199; Cossarizza A; Mussini C; Mongiardo N; Borghi V; Sabbatini A; De Rienzo B; Franceschi C; Department of Biomedical Sciences, University of Modena School of; Medicine, Italy.; OBJECTIVE: To study alterations of mitochondrial membrane potential (delta psi) and the propensity to undergo apoptosis in peripheral blood lymphocytes (PBL) from subjects with acute HIV syndrome; and to evaluate possible modulations of these phenomena by antioxidants that can be used in therapy, such as N-acetyl-cyst
gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals: an immunoelectron microscopic study.: AIDS. 1997 Jan;11(1):27-32. Unique Identifier : AIDSLINE MED/97264200; Sunila I; Vaccarezza M; Pantaleo G; Fauci AS; Orenstein JM; George Washington University Medical Center, Department of Pathology,; Washington, DC 20037, USA.; OBJECTIVE: To study whether free gp120 can be detected on the plasma membranes of apoptotic CD4+ T lymphocytes in lymph nodes from HIV-positive patients. METHODS: Lymph-node cell suspensions prepared from three HIV-positive patients were studied by pre-embedding, double-immunogold-labeling to identify cell type, deter
N-acetyl-cysteine and L-2-oxothiazolidine-4-carboxylic acid enhance contact-dependent growth of HIV in resting peripheral blood mononuclear cells (PBMC) in vitro and increase recovery of HIV from human-PBMC SCID mice.: AIDS. 1997 Jan;11(1):33-41. Unique Identifier : AIDSLINE MED/97264201; Chen P; Bauer G; Mitchell J; Factor R; Markham R; Schwartz DH; Department of Molecular Microbiology and Immunology, School of Hygiene; and Public Health, Johns Hopkins University, Baltimore, Maryland; 21205, USA.; OBJECTIVES: To ascertain the effects of N-acetyl-cysteine (NAC) and L-2-oxothiazolidine-4-carboxylic acid (OTC) on HIV replication in resting T lymphocytes mixed with chronically infected U1 promonocytic cells; examine the phenotypes of NAC- and OTC-treated cells; and monitor HIV recovery from hu-PBMC SCID mice (SCID
Presence of multiple non-B subtypes and divergent subtype B strains of HIV-1 in individuals infected after overseas deployment.: AIDS. 1997 Jan;11(1):43-51. Unique Identifier : AIDSLINE MED/97264202; Lasky M; Perret JL; Peeters M; Bibollet-Ruche F; Liegeois F; Patrel D; Molinier S; Gras C; Delaporte E; Retrovirus Laboratory, ORSTOM, Montpellier, France.; OBJECTIVE: To identify the genetic subtypes and characteristics of HIV-1 strains from individuals infected after overseas deployment. PATIENTS AND METHODS: Sixty-one HIV-1-positive individuals detected between 1986 and 1995 in the French army were included in the study. For each patient, the year and country of HIV in
Viral load in asymptomatic patients with CD4+ lymphocyte counts above 500 x 10(6)/l.: AIDS. 1997 Jan;11(1):53-7. Unique Identifier : AIDSLINE MED/97264203; Garcia F; Vidal C; Gatell JM; Miro JM; Soriano A; Pumarola T; Infectious Diseases Unit, Hospital Clinic i Provincial, University of; Barcelona, Spain.; BACKGROUND: HIV-1-infected patients with a CD4+ lymphocyte count > or = 500 x 10(6)/l may be selected for antiretroviral treatment when viral load is above a given cut-off point. OBJECTIVES: To assess the stability of viral load measurement at CD4+ T-cell counts above 500 x 10(6)/l, and the proportion of patients sele
Effect of combination therapy with zidovudine and didanosine on neuropsychological functioning in patients with symptomatic HIV disease: a comparison of simultaneous and alternating regimens.: AIDS. 1997 Jan;11(1):59-66. Unique Identifier : AIDSLINE MED/97264204; Brouwers P; Hendricks M; Lietzau JA; Pluda JM; Mitsuya H; Broder S; Yarchoan R; HIV and AIDS Malignancy Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-1928, USA.; OBJECTIVE: To evaluate the effects of treatment with alternating and simultaneous regimens of zidovudine and didanosine on neuropsychological function in patients with symptomatic HIV-1 disease, focusing on patients with possible HIV-1-associated central nervous system (CNS) compromise at entry. DESIGN: Randomized non
Antiretroviral effect of zidovudine-didanosine combination on blood and lymph nodes.: AIDS. 1997 Jan;11(1):67-72. Unique Identifier : AIDSLINE MED/97264205; Lafeuillade A; Tamalet C; Poggi C; Pellegrino P; Tourres C; Izopet J; Department of Infectious Diseases, General Hospital, Toulon, France.; OBJECTIVE: To evaluate the antiretroviral effect of a combination of zidovudine (ZDV) and didanosine (ddl) on plasma, peripheral blood mononuclear cells (PBMC) and lymph nodes after 24 weeks. METHODS: Eight patients naive of antiretroviral therapy were followed by monthly blood samples and two surgical lymph-node biop
Male circumcision and susceptibility to HIV infection among men in Tanzania [corrected and republished in AIDS 1997 Mar;11(3):73-80]: AIDS. 1997 Jan;11(1):73-9. Unique Identifier : AIDSLINE MED/97264206; Urassa M; Todd J; Boerma JT; Hayes R; Isingo R; Tanzania-Netherlands Project to Support AIDS Control in Mwanza region; (TANESA), Mwanza, Tanzania.; BACKGROUND: Evidence from ecological studies and from studies of and sexually transmitted disease (STD) patients in sub-Saharan Africa suggests that there is a protective effect of male circumcision against HIV infection. There are, however, few population-based studies that have controlled adequately for potential co
An association between HIV-1 subtypes and mode of transmission in Cape Town, South Africa [see comments]: AIDS. 1997 Jan;11(1):81-7. Unique Identifier : AIDSLINE MED/97264207; van Harmelen J; Wood R; Lambrick M; Rybicki EP; Williamson AL; Williamson C; Department of Medical Microbiology, University of Cape Town,; Observatory, South Africa.; OBJECTIVES: To determine HIV-1 env and gag subtypes in male homosexual and heterosexual populations in Cape Town, South Africa . DESIGN: DNA was isolated from blood originating from 61 patients attending local clinics. Samples were divided according to presumed mode of transmission
HIV-1 infection among female commercial sex workers in rural Thailand.: AIDS. 1997 Jan;11(1):89-94. Unique Identifier : AIDSLINE MED/97264208; Gray JA; Dore GJ; Li Y; Supawitkul S; Effler P; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, Sydney, Australia.; OBJECTIVE: To reconstruct past HIV-1 incidence and identify risk factors for HIV-1 seroconversion among female commercial sex workers in a semi-rural setting in northern Thailand . DESIGN: Retrospective cohort of sex workers attending a sexually transmitted disease (STD) clinic at
The effect of the 1993 European revision of the AIDS case definition in Italy: implications for modelling the HIV epidemic.: AIDS. 1997 Jan;11(1):95-9. Unique Identifier : AIDSLINE MED/97264209; Pezzotti P; Napoli PA; Rezza G; Lazzeri V; Acciai S; Curia R; Crosera C; De Rosa MG; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome, Italy.; OBJECTIVES: To evaluate the effect of the 1993 European AIDS definition on reducing pre-AIDS mortality and to what degree an earlier diagnosis can be made. DESIGN: Prospective observational study. METHODS: All patients diagnosed between January 1993 and December 1994 and reported to the National AIDS Registry from fou
Childhood infections with human herpesviruses types 6, 7, and 8.: Adv Pediatr Infect Dis. 1996;12:181-208. Unique Identifier : AIDSLINE MED/97186404; Grose C; University of Iowa College of Medicine, Iowa City, USA.
Antiretroviral therapy: evaluating the new era in HIV treatment.: Adv Pediatr Infect Dis. 1996;12:297-323. Unique Identifier : AIDSLINE MED/97186407; McKinney RE Jr; Duke University Medical Center, Durham, North Carolina, USA.; Tools for evaluating antiretroviral therapy are still evolving. Key components are available such as the laboratory assays themselves, but results from these assays are being analyzed and presented inconsistently, making interstudy comparisons difficult or impossible. In part, the problems in analysis and presentation
Subglottic stenosis in an HIV positive patient: an exceptional form of clinical presentation in Kaposi's sarcoma.: Eur J Cardiothorac Surg. 1997 Jan;11(1):191-3. Unique Identifier : AIDSLINE MED/97182672; Belda J; Canalis E; Gimferrer JM; Xaubet A; Baldo X; Guelar A; Department of Thoracic Surgery, Infectious Diseases and Pneumology,; Hospital Clinic, Universitat de Barcelona, Spain.; The case of a 29-year-old HIV positive male patient suffering from a Kaposi s sarcoma exclusively located in the proximal third of the trachea and subglottic region is presented. The patient was found to have included an obstruction of the upper airway. A characteristic endoscopic appearance led to the final diagnosis
Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells.: Br J Haematol. 1997 Mar;96(4):733-5. Unique Identifier : AIDSLINE MED/97228335; Mu X; Kay NE; Gosland MP; Jennings CD; Division of Hematology, University of Kentucky Medical Center,; Lexington, USA.; The cytoplasmic cytokines of purified blood T cells (CD4/CD8) in B-CLL patients (n = 5) and controls (n = 5) were evaluated by flow cytometry. The mean levels of cytoplasmic IL-4 were significantly elevated in resting and activated B-CLL CD8 cells compared to control CD8 cells. IL-4 cytoplasmic levels were comparable
Absence of Kaposi's sarcoma associated herpesvirus-like DNA sequences (KSHV) in HIV-negative multicentric Castleman's disease complicated by KSHV-positive Kaposi's sarcoma [letter]: Br J Haematol. 1997 Mar;96(4):881-2. Unique Identifier : AIDSLINE MED/97228365; Kwong YL; Chan AC
Integrating primary care and methadone maintenance treatment: implementation issues.: J Addict Dis. 1997;16(1):91-102. Unique Identifier : AIDSLINE MED/97198392; Herman M; Gourevitch MN; Department of Family Medicine, Montefiore Medical Center, Albert; Einstein College of Medicine, Bronx, NY 10467, USA.; Linking primary medical care with methadone maintenance treatment brings critical services to drug users, many with HIV/AIDS, tuberculosis and other illnesses. However, a variety of important philosophical, ethical, and systems issues may impede the process of implementing a linked service delivery model. Conflictin
Hospital epidemiology--1997.: Va Med Q. 1997 Spring;124(2):103-4. Unique Identifier : AIDSLINE MED/97255125; Wenzel RP; Edmond MB; Nettleman MD; Department of Internal Medicine, Medical College of Virginia/Virginia; Commonwealth University, Richmond 23298-0019, USA.; Selected issues for hospital epidemiology are presented. The issues of infection control, employee health and quality assessment cross the traditional department and reporting lines and require a multidisciplinary approach utilizing the epidemiological method. Programs seeking enhanced value--high quality outcomes per
HIV update.: Va Med Q. 1997 Spring;124(2):105-7. Unique Identifier : AIDSLINE MED/97255126; Schmidt ME; Infectious Disease Consultants, LLC, Fairfax VA, USA.
Irradiated NC adenocarcinoma cells transduced with both B7.1 and interleukin-2 induce CD4+-mediated rejection of established tumors.: Hum Gene Ther. 1997 Mar 1;8(4):477-88. Unique Identifier : AIDSLINE MED/97207029; Gaken JA; Hollingsworth SJ; Hirst WJ; Buggins AG; Galea-Lauri J; Peakman M; Kuiper M; Patel P; Towner P; Patel PM; Collins MK; Mufti GJ; Farzaneh F; Darling DC; Department of Molecular Medicine, King's College School of Medicine &; Dentistry, London, UK.; Previous studies have shown that expression of the immune co-stimulator B7.1 reduces the tumorigenicity of some, but not all, malignant cell lines. However, B7.1-expressing tumor cells are not very effective in inducing the rejection of established tumors. This may in part be due to induction of anergy in the potentia
DNA and amino acid sequence of anti-HIV-1 Rev sFv.: Hum Gene Ther. 1997 Mar 1;8(4):510. Unique Identifier : AIDSLINE MED/97207030; Duan L; Zhang H; Oakes JW; Bagasra O; Pomerantz RJ
Cell-mediated immune system regulation in periodontal diseases.: Crit Rev Oral Biol Med. 1997;8(1):76-89. Unique Identifier : AIDSLINE MED/97217665; Mathur A; Michalowicz BS; Department of Oral Science, School of Dentistry, University of; Minnesota, Minneapolis, USA.; The adaptive immune system consists of humoral and cell-mediated immunity. T-lymphocytes are the key components of cell-mediated immunity. CD4+ helper T-lymphocytes facilitate B-cells to differentiate and produce specific antibodies, whereas CD8+ cytotoxic T-lymphocytes kill virally infected cells. Periodontal disease
Management of histologically aggressive lymphomas with a high risk of CNS disease.: Baillieres Clin Haematol. 1996 Dec;9(4):707-26. Unique Identifier : AIDSLINE MED/97227066; Horak ID; Kremer AB; Magrath IT; Janssen Research Foundation, Titusville, NJ 08650, USA.; The NHLs are a group of neoplasms that share a common target tissue, and are characterized by a high degree of biological and clinical heterogeneity. Adult lymphomas with a high propensity for CNS involvement comprise SNCC, lymphoma (ATLL), LL, and PCL of immunocompromised patients. Despite recently reported encouragi
Sequential development of resistance to fluoroquinolones and erythromycin in an isolate of Campylobacter jejuni.: Zentralbl Bakteriol. 1996 Mar;283(3):314-21. Unique Identifier : AIDSLINE MED/97015036; Burnens AP; Heitz M; Brodard I; Nicolet J; National Reference Laboratory for Foodborne Diseases, University of; Berne, Berne, Switzerland.; A severe episode of Campylobacter jejuni gastroenteritis in a patient with HIV infection was treated with ciprofloxacin and, because of therapeutic failure, subsequently with roxithromycin. After treatment, C. jejuni was again isolated from feces and shown to be resistant to both drugs. We present molecular evidence o
Performance of HTLV-1 screening assays in Brazil.: Zentralbl Bakteriol. 1996 Mar;283(3):340-6. Unique Identifier : AIDSLINE MED/97276740; Beck A; Lima MC; Castro MC; Drummond DX; Oliveira ML; Oelemann W; Pauli G; van Tilburg Bernardes YS; Departamento de Sangue e Hemoderivados, Instituto Nacional de; Qualidade em Saude (INCQS-DSH), Rio de Janeiro, Brazil.; In recent years a variety of studies have been carried out to compare the accuracy (generally expressed in terms of sensitivity and specificity) of commercially available anti-HTLV tests. None of these studies were performed in Brazil or in any other South American country. During
Cryptococcosis associated with HIV negative Indian patients and HIV positive Indian blood donors.: Zentralbl Bakteriol. 1996 Mar;283(3):360-74. Unique Identifier : AIDSLINE MED/97015042; Khan ZK; Katiyar R; Shukla R; Kulshreshtha R; Mathur A; Medical Mycology Division, Central Drug Research Institute, Lucknow,; India.; Cryptococcosis, particularly cryptococcal meningitis (CM), has become an increasing problem globally in the AIDS era. In the present investigation we have made an effort for the first time to study Indian cases (100) both HIV-positive (23 cases, male, mostly Indian professional blood donors, PBDs ) confirmed by an ELI
Steady-state calculation of the risk of HIV infection from transfusion of screened blood from repeat donors.: Math Biosci. 1997 Apr 15;141(2):101-13. Unique Identifier : AIDSLINE MED/97257262; Satten GA; Division of HIV/AIDS (E-48), National Center for HIV, STD, and TB; Prevention, Centers for Disease Control and Prevention, Atlanta,; Georgia 30333, USA.; All blood donations in the United States are screened for human immunodeficiency virus (HIV), the virus that causes AIDS; in spite of this, potentially infectious donations are still made by donors who are infectious but have not yet developed detectable HIV antibodies. A steady-state
A three-dimensional NMR experiment with improved sensitivity for carbonyl-carbonyl J correlation in proteins.: J Biomol NMR. 1997 Feb;9(2):207-11. Unique Identifier : AIDSLINE MED/97245375; Grzesiek S; Bax A; Laboratory of Chemical Physics, National Institutes of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892-0520, USA.; Recently, a quantitative J correlation technique has been presented that permits measurement of 3Jc c in proteins isotopically enriched with 13C [Hu, J.-S. and Bax, A. (1996) J. Am. Chem. Soc., 118, 8170-8171]. Here, we describe an analogous experiment that is less sensitive to transverse 13C relaxation, which is th
Seroepidemiological profile of 50 AIDS patients in Kerala [letter]: Natl Med J India. 1996 Nov-Dec;9(6):299. Unique Identifier : AIDSLINE MED/97265975; Jose L; Legori M
Public health. Orphaned by AIDS.: Hosp Health Netw. 1997 Apr 5;71(7):88, 90. Unique Identifier : AIDSLINE MED/97273095; Swan H
Evolution of risk behaviors over 2 years among a cohort of urban African American adolescents.: Arch Pediatr Adolesc Med. 1997 Apr;151(4):398-406. Unique Identifier : AIDSLINE MED/97265525; Stanton B; Fang X; Li X; Feigelman S; Galbraith J; Ricardo I; Department of Pediatrics, University of Maryland School of Medicine,; Baltimore, USA.; OBJECTIVE: To examine the evolution of risk behaviors over 2 years among a community-based cohort of low-income African American preadolescents and young adolescents enrolled in a randomized trial of an acquired immunodeficiency syndrome risk reduction intervention. DESIGN: Longitudinal, community-based cohort. SETTIN
Fungal infections.: Brain Pathol. 1997 Jan;7(1):613-27. Unique Identifier : AIDSLINE MED/97187116; Chimelli L; Mahler-Araujo MB; Departamento de Patologia, Faculdade de Medicina de Ribeirao Preto,; SP, Brasil.; Fungal infections have increased in frequency in the last decades because of the growing number of immunocompromised patients who survive longer periods of time than in the past, the widespread use of immunosuppressive drugs, a large aging population with increased numbers of malignancies, and the spread of AIDS. Alth
Viruses and rickettsiae.: Brain Pathol. 1997 Jan;7(1):695-709. Unique Identifier : AIDSLINE MED/97187122; Esiri MM; Department of Neuropathology and Clinical Neurology, Radcliffe; Infirmary, Oxford, UK. mmesiri@clneuro.ox.ac.uk; In this review I shall try to provide a brief, up-to-date, account of the neuropathology of those viral and rickettsial diseases that are particularly prevalent in tropical regions. These diseases are not, however, exclusive to the tropics. Some, such as AIDS, are common in temperate regions as well, though others are
Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients.: Am J Respir Crit Care Med. 1997 Apr;155(4):1474-7. Unique Identifier : AIDSLINE MED/97258926; Kurashima K; Mukaida N; Fujimura M; Yasui M; Nakazumi Y; Matsuda T; Matsushima K; Third Department of Internal Medicine, School of Medicine, Kanazawa; University, Japan.; In pulmonary tuberculosis, the proportion of lymphocytes, particularly that of CD4+ T lymphocytes, was increased in bronchoalveolar lavage fluid (BALF), reflecting their protective role against mycobacterial infections. In order to elucidate the mechanisms of lymphocyte accumulation in lungs, we measured the levels of
Reliability of anergy skin testing in persons with HIV infection [letter; comment]: Am J Respir Crit Care Med. 1997 Apr;155(4):1490. Unique Identifier : AIDSLINE MED/97258931; Klein RS; Gourevitch MN
Maintenance of chemoprophylaxis against Pneumocystis carinii despite combination antiretroviral treatment associated CD4+ T-lymphocytosis [letter]: Am J Respir Crit Care Med. 1997 Apr;155(4):1491. Unique Identifier : AIDSLINE MED/97258932; Macher AM; Goosby EP
AIDS pathology: infections and neoplasms in 55 fatal AIDS cases. A postmortem study.: Pol J Pathol. 1996;47(4):163-70. Unique Identifier : AIDSLINE MED/97252118; Walewska-Zielecka B; Kaminski Z; Nowoslawski A; Department of Immunopathology, National Institute of Hygiene,; Warszawa.; The study evaluated the incidence of infections and neoplasms in 55 out of 104 patients with AIDS who died in Poland from January 1986 to April 1994 (the estimated autopsy rate-52.8%). Histopathological examination revealed 103 infe
C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases.: Bioorg Med Chem. 1996 Dec;4(12):2055-69. Unique Identifier : AIDSLINE MED/97175311; Qian X; Moris-Varas F; Fitzgerald MC; Wong CH; Department of Chemistry, Scripps Research Institute, La Jolla, CA; 92037, USA.; C2-Symmetrical tetrahydroxyazepanes were synthesized as inhibitors for glycosidases. Tetrahydroxyazepane 1 is a non-specific inhibitor of various glycosidases, while compounds 2, 3 and 4 specifically inhibit beta-N-acetylglucosaminidase, beta-glucosidase, and alpha-fucosidase, respectively, with Ki in the micromolar r
National AIDS Malignancy Conference. Bethesda, Maryland, April 28-30, 1997. Abstracts.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):A1-54. Unique Identifier : AIDSLINE MED/97278836
Primary proliferative responses to peptides of HIV Gag p24.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):301-6. Unique Identifier : AIDSLINE MED/97265565; Bedford PA; Clarke LB; Hastings GZ; Knight SC; Antigen Presentation Research Group, Imperial College School of; Medicine, Northwick Park Institute for Medical Research, Harrow,; England, U.K.; Primary proliferative responses can be initiated by adding dendritic cells pulsed with antigen to autologous T cells in 20-microliter hanging drop cultures. To identify primary T-cell epitopes of HIV gag, a series of 23 overlapping peptides, 15 amino acids long, spanning the p24 region were used. Significant prolifera
Maternal serum vitamin A levels are not associated with mother-to-child transmission of HIV-1 in the United States.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):321-6. Unique Identifier : AIDSLINE MED/97265567; Burger H; Kovacs A; Weiser B; Grimson R; Nachman S; Tropper P; van Bennekum AM; Elie MC; Blaner WS; Wadsworth Center, New York State Department of Health, Albany, USA.; HIV-1 transmission from mother to child has been associated with maternal vitamin A status in studies of women living in Africa. This finding has raised the question of whether vitamin A supplementation might help reduce transmission in the United States as well as worldwide. In indust
Cigarette smoking and maternal-child HIV transmission.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):327-37. Unique Identifier : AIDSLINE MED/97265568; Turner BJ; Hauck WW; Fanning TR; Markson LE; Division of General Internal Medicine, Jefferson Medical College,; Philadelphia, Pennsylvania, USA.; We investigated the association of cigarette smoking with maternal-child HIV transmission, adjusting for illicit drug use, maternal clinical status, and delivery factors. Vital statistics birth data were linked to the New York State Medicaid HIV/AIDS Research Database for HIV-infected women delivering a liveborn singl
Effect of cigarette smoking on HIV-related oral lesions.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):338-42. Unique Identifier : AIDSLINE MED/97265569; Palacio H; Hilton JF; Canchola AJ; Greenspan D; Department of Medicine, University of California, San Francisco; 94143-0422, USA.; To determine whether the presence of specific oral lesions is associated with cigarette smoking among HIV-infected patients, we analyzed cross-sectional data (CD4 cell count, smoking history, and oral examination findings) from 1,058 HIV-infected male patients who received clinical care at the University of California
Effect of immunization with an inactivated gp120-depleted HIV-1 immunogen on beta-chemokine and cytokine production in subjects with HIV-1 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):343-50. Unique Identifier : AIDSLINE MED/97265570; Moss RB; Trauger RJ; Giermakowska WK; Turner JL; Wallace MR; Jensen FC; Richieri SP; Ferre F; Daigle AE; Duffy C; Theofan G; Carlo DJ; Immune Response Corporation, Carlsbad, California 92008, USA.; OBJECTIVE: To measure beta-chemokine and cytokine production in HIV-1-infected subjects undergoing treatment with HIV-1 immunogen REMUNE). DESIGN: Open label treatment study. METHODS: beta-Chemokine and cytokine production in peripheral blood mononuclear cell (PBMC) culture. RESULTS: Interferon-gamma production (p = 0
The impact of primary central nervous system lymphoma in AIDS patients: a population-based autopsy study from Oslo.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):351-4. Unique Identifier : AIDSLINE MED/97265571; Goplen AK; Dunlop O; Liestol K; Lingjaerde OC; Bruun JN; Maehlen J; Department of Pathology, Ullev~al University Hospital, Oslo, Norway.; This study comprises the 255 adult AIDS patients treated at Ullev~al hospital 1983-1995. These patients, fulfilling the Centers of Disease Control (CDC) clinical criteria for AIDS, correspond to 91% of all adult AIDS cases in Oslo. By the end of the study period, 44 patients were alive and 211 had died. Full autopsy w
Update on the seroepidemiology of human immunodeficiency virus in the United States household population: NHANES III, 1988-1994.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):355-60. Unique Identifier : AIDSLINE MED/97265572; McQuillan GM; Khare M; Karon JM; Schable CA; Vlahov D; Division of Health Examination Statistics, National Center for Health; Statistics, Hyattsville, MD 20782, USA.; To update the estimate of seroprevalence of HIV from the third National Health and Nutrition Examination Survey (NHANES III), data from the second phase of the survey were combined with previously published data to produce a more precise estimate. The testing was performed anonymously on 11,203 individuals 18-59 years
CD4+ T-lymphocyte counts in HIV infection: are European standards applicable to African patients?: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):361-7. Unique Identifier : AIDSLINE MED/97265573; Anglaret X; Diagbouga S; Mortier E; Meda N; Verge-Valette V; Sylla-Koko F; Cousens S; Laruche G; Ledru E; Bonard D; Dabis F; Van de Perre P; CeDReS, CHU de Treichville, Abidjan, Cote d'Ivoire.; CD4+ lymphocyte count (CD4+ LC) is a widely used marker of Human Immunodeficiency Virus (HIV) immune impairment. Physiological lymphocytosis is frequently encountered in Africans. Therefore, we tried to determine if given CD4+ LC levels are of similar significance in European versus African HIV-infected individuals. L
Blood collection on filter paper: a practical approach to sample collection for studies of perinatal HIV transmission.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):368-73. Unique Identifier : AIDSLINE MED/97265574; Biggar RJ; Miley W; Miotti P; Taha TE; Butcher A; Spadoro J; Waters D; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; Maryland, USA.; The use of dried blood spots lends itself to widespread application in large field studies, especially in remote areas. We present experience gained during a perinatal HIV transmission study in southern Africa in which dried blood spot samples were used for polymerase chain reaction (PCR) tests. In this study, 15,810
Surveillance for thrombocytopenia in persons infected with HIV: results from the multistate Adult and Adolescent Spectrum of Disease Project [published erratum appears in J Acquir Immune Defic Syndr Hum Retrovirol 1997 May 1;15(1):94]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):374-9. Unique Identifier : AIDSLINE MED/97265575; Sullivan PS; Hanson DL; Chu SY; Jones JL; Ciesielski CA; Division of HIV/AIDS Prevention, National Center for HIV, Sexually; Transmitted Diseases and Tuberculosis Prevention, Atlanta, Georgia,; USA.; Thrombocytopenia in persons infected with HIV is prevalent and has numerous causes. To study the occurrence, associations, and effect on survival of thrombocytopenia in HIV-infected persons, we used surveillance data from a longitudinal survey of the medical records of 30,214 HIV-infected patients who received medical
Lifetime costs of HIV/AIDS medical care [letter; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):380-2. Unique Identifier : AIDSLINE MED/97265576; Pinkerton SD; Holtgrave DR
[Neuronal apoptosis in the course of human immunodeficiency virus infection]: Bull Acad Natl Med. 1996 Nov;180(8):1855-67; discussion 1867-8. Unique Identifier : AIDSLINE MED/97229657; Gray F; Adle-Biassette H; Levy Y; Wingertsmann L; Hery C; Tardieu M; Laboratoire d'Anatomie Pathologique (Neuropathologie), Hopital Raymond; Poincare-Faculte de Medecine Paris-Ouest, Garches, France.; Apart from the unique changes characteristic of HIV encephalitis , the productive infection of central nervous system by HIV, which involves predominantly the white matter and basal ganglia, evidence is accumulating that the cerebral cortex may also be affected in AIDS patients. Neuronal loss, suspected at microscopi
Psychosocial predictors of HIV risk among adolescent offenders who abuse drugs.: Psychiatr Serv. 1997 Feb;48(2):185-7. Unique Identifier : AIDSLINE MED/97173980; Malow RM; McMahon R; Cremer DJ; Lewis JE; Alferi SM; Department of Psychiatry and Behavioral Sciences, University of Miami,; Jackson Memorial Medical Center, FL 33136, USA.
Incidence of HIV infection among patients with new-onset psychosis.: Psychiatr Serv. 1997 Feb;48(2):237-8. Unique Identifier : AIDSLINE MED/97173990; Doyle ME; Labbate LA; Department of Psychiatry, Walter Reed Army Medical Center, USA.; To assess the frequency of HIV testing and the incidence of HIV infection among patients with new-onset psychosis, the records of 811 patients referred to a military hospital for acute psychosis during a two-year period were reviewed. Records of 518 patients were excluded because they had known chronic psychotic illne
Verbal intercourse and sexual communication: impediments to STD prevention.: Med Anthropol Q. 1997 Mar;11(1):89-109. Unique Identifier : AIDSLINE MED/97227462; Pliskin KL; Medical Anthropology Program, University of California, San Francisco,; USA.; This article explores the problems of risky sexual behavior by examining the ways people verbally negotiate sexual interaction regarding sexually transmitted diseases. Based on in-depth interviews with 124 adults (ages 21-63) who are infected with genital herpes , the article sho
Evidence of nosocomial transmission of tuberculosis among AIDS patients by DNA fingerprinting.: New Microbiol. 1996 Oct;19(4):285-91. Unique Identifier : AIDSLINE MED/97071203; Garzelli C; Lari N; Nguon B; Falcone G; Department of Biomedicine, University of Pisa, Italy.; DNA restriction fragment length polymorphism (RFLP) analysis was performed on Mycobacterium tuberculosis isolates from patients in the human immunodeficiency virus (HIV) Unit of a community hospital. It was found that M. tuberculosis isolates from two patients with AIDS shared an identical RFLP pattern. Such a fingerp
Morphotypes of Candida albicans and their associations with underlying diseases and source of samples.: New Microbiol. 1996 Oct;19(4):335-43. Unique Identifier : AIDSLINE MED/97071210; Riviera L; Bellotti MG; Malighetti V; Istituto di Microbiologia, Universita degli Studi di Catania.; The morphotyping method was applied to differentiate a series of 276 Candida albicans strains recovered from hospitalized patients, by using a three-digit code based on the characteristics of the fringe outgrowth. By this scheme 32 different morphotypes were identified. An 86% reproducibility was achieved. The aim of
Topical thymopentin therapy in HIV positive patients with recurrent oral candidiasis: a pilot study.: New Microbiol. 1996 Oct;19(4):351-5. Unique Identifier : AIDSLINE MED/97071212; Coppola S; Buccoliero G; Laddago V; Monno L; Perrone A; Guida G; Schiraldi O; Angarano G; Infectious Diseases Clinic, University of Bari, Italy.; Oral candidiasis frequently occurs in HIV-positive patients especially in those with advanced disease. To date, common anti-mycotic drugs are unable to prevent relapses and alternative therapy is necessary to reduce disabling effects. With the aim of verifying whether thymic hormone extract may be efficacious in these
A five-factor model of personality and addiction, psychiatric, and AIDS risk severity in pregnant and postpartum cocaine misusers.: Subst Use Misuse. 1997 Jan;32(1):25-41. Unique Identifier : AIDSLINE MED/97197475; Ball SA; Schottenfeld RS; Department of Psychiatry, Yale University, School of Medicine, New; Haven, Connecticut, USA.; The relationship between addiction severity, psychiatric symptoms, AIDS risk behaviors, and an alternative five-factor measure of personality, the Zuckerman-Kuhlman Personality Questionnaire, was assessed in 92 cocaine-misusing pregnant and postpartum women in an inner city outpatient treatment program. Three of the p
Perceptions of rural addictions and related HIV.: Subst Use Misuse. 1997 Jan;32(1):83-8. Unique Identifier : AIDSLINE MED/97197479; Leukefeld CG; Godlaski T; Center on Drug and Alcohol Research, University of Kentucky, Lexington; 40536-0080, USA.; Rural addictions and related HIV behaviors, including drug use and sexual behaviors, have received limited attention in United States rural areas when compared with urban areas. However, prevalence rates are similar for alcohol and tobacco in rural and urban United States areas. The pe
[A case of chronic active viral hepatitis B combined with HIV carriage, malaria and syphilis]: Lik Sprava. 1996 Oct-Dec;(10-12):158-9. Unique Identifier : AIDSLINE MED/97240001; Shkurba AV; Pashkovs'ka KH; Anastasii IA; Holubovs'ka OA; Poliakova OO
Sexual behaviour and prevalence of HIV antibodies in transsexuals.: J Obstet Gynaecol Res. 1997 Feb;23(1):33-6. Unique Identifier : AIDSLINE MED/97248834; Chew S; Tham KF; Ratnam SS; Department of Obstetrics and Gynaecology, National University of; Singapore, National University Hospital, Singapore.; OBJECTIVE: To present data on the social characteristics, sexual behaviour and prevalence of HIV antibodies in 277 transsexuals. MATERIAL AND METHODS: One hundred fifty-four male and 123 female transsexuals requesting surgical gender reassignment at the National University Hospital,
Substitution of testosterone in a HIV-1 positive patient with hypogonadism and Wasting-syndrome led to a reduced rate of apoptosis.: Eur J Med Res. 1997 Jan;2(1):30-2. Unique Identifier : AIDSLINE MED/97202058; Klein SA; Klauke S; Dobmeyer JM; Dobmeyer TS; Helm EB; Hoelzer H; Rossol R; Johann Wolfgang Goethe Universitat Frankfurt, Medizinische Klinik III,; Frankfurt, Germany.; Peripheral blood mononuclear cells from HIV infected individuals develop in vitro apoptosis to a much higher extent than healthy donors. Aside from the direct cytopathic effect of HIV, programmed cell death can be induced by such cytokine system imbalance as seen with increased levels of TNF-alpha or the Th1-->Th2-cyt
Communicable diseases surveillance.: Commun Dis Intell. 1997 Mar 20;21(6):80-7. Unique Identifier : AIDSLINE MED/97245439
Glutathione and cysteine in HIV-infected hemophiliacs.: Clin Chim Acta. 1996 Oct 15;254(1):63-72. Unique Identifier : AIDSLINE MED/97049582; Lopez Galera RM; Juarez Gimenez JC; Montoro Ronsano JB; Segura Cardona RM; Arbos Via MA; Altisent Roca C; Tusell Puigbert JM; Department of Haemophilia, Ciudad Sanitaria Valley de Hebron,; Barcelona, Spain.; A cross-sectional study was designed to determine whether plasma concentrations of glutathione and cysteine in HIV-infected hemophiliacs vary according to the progression of the disease and to compare them with those obtained in HIV negative hemophiliacs. Cysteine, total glutathione and glutathione disulphide were mea
Putting numbers on mycobacterium activated T cell subsets [editorial]: Clin Exp Immunol. 1996 Jun;104(3):381-3. Unique Identifier : AIDSLINE MED/97254508; Ottenhoff TH
Tuberculosis. Part I.: Dis Mon. 1997 Mar;43(3):113-80. Unique Identifier : AIDSLINE MED/97259154; McDermott LJ; Glassroth J; Mehta JB; Dutt AK; Allegheny University of the Health Sciences, Philadelphia,; Pennsylvania, USA.; Tuberculosis has been a disease of human beings for thousands of years. In recent times it has waxed to become the feared White Plague of the eighteenth and nineteenth centuries and waned under the impact of effective chemotherapy until its elimination seemed possible by the early twenty-first century. The resurgence
Pregnancy outcome in HIV-1 positive women in Gandhi Memorial Hospital Addis Ababa, Ethiopia.: East Afr Med J. 1996 Dec;73(12):805-9. Unique Identifier : AIDSLINE MED/97256999; Chamiso D; Department of Obstetrics and Gynaecology, Addis Ababa University,; Faculty of Medicine, Ethiopia.; Between January 1993 and January 1995, a prospective case-control hospital-based study was done in ninety-two HIV seropositive and 173 HIV seronegative mothers for pregnancy outcome and complications associated with the pregnancy in Gandhi Memorial Hospital, Addis Ababa, Ethiopia
Oro-facial lesions occurring in HIV-infected individuals in Dar es Salaam.: East Afr Med J. 1996 Dec;73(12):813-5. Unique Identifier : AIDSLINE MED/97257001; Matee MI; Moshi J; Kalyanyama B; Department of Microbiology and Immunology, Muhimbili University; College of Health Sciences, Dares Salaam, Tanzania.; This study demonstrates a strong association between the occurrence of oro-facial lesions and HIV-1 seropositivity in a group of patients in Dar es Salaam. Among the different oro-facial lesions Kaposi s sarcoma seems to be the most frequent and the most important pathognomonic feature. Since some of the lesions occur
HIV-1 infection in relation to educational status, use of hypodermic injections and other risk behaviours in Ethiopian sailors.: East Afr Med J. 1996 Dec;73(12):819-22. Unique Identifier : AIDSLINE MED/97257003; Demissie K; Amre D; Tsega E; Department of Epidemiology and Biostatistics, McGill University,; Montreal, Quebec, Canada.; Information on the prevalence and risk factors for HIV infection among sailors is generally scarce. The objectives of the study were to determine the prevalence and risk factors for HIV-1 infection among sailors in Ethiopia . A cross-sectional study was carried out in a population
Nutritional status and dietary intakes in human immunodeficiency virus (HIV)-infected outpatients in Abidjan, Cote D'Ivoire, 1995.: Eur J Clin Nutr. 1997 Feb;51(2):81-6. Unique Identifier : AIDSLINE MED/97202032; Castetbon K; Kadio A; Bondurand A; Boka Yao A; Barouan C; Coulibaly Y; Anglaret X; Msellati P; Malvy D; Dabis F; Unite INSERM 330, Universite de Bordeaux II, France.; OBJECTIVE: To evaluate nutritional status and dietary intakes in HIV-outpatients in Abidjan, Cote d Ivoire . DESIGN: Cross-sectional study. SETTING: In the Outpatients and Counselling Unit in the University Hospital in Treichville, and in the follow-up Unit of Blood Donors. SUB
Influence of CD4+ status on the invasiveness of pneumococcal pneumonia in HIV patients [letter]: Eur J Clin Microbiol Infect Dis. 1996 Dec;15(12):959-60. Unique Identifier : AIDSLINE MED/97183923; Clavo-Sanchez AJ; Giron-Gonzalez JA; Lopez-Prieto D; Torres-Tortosa M; Sanchez-Porto A
Agrobacterium radiobacter pneumonia in a patient with HIV infection [letter]: Eur J Clin Microbiol Infect Dis. 1996 Dec;15(12):960-3. Unique Identifier : AIDSLINE MED/97183924; Mastroianni A; Coronado O; Nanetti A; Manfredi R; Chiodo F
Diagnosis of visceral leishmaniasis in HIV-infected patients [letter]: Eur J Clin Microbiol Infect Dis. 1996 Dec;15(12):967-8. Unique Identifier : AIDSLINE MED/97183927; Gasser I; Jaen A; Gonzalez J; Ribera E
Cardiac tamponade as the first manifestation of AIDS [letter]: Eur Heart J. 1996 Nov;17(11):1771-2. Unique Identifier : AIDSLINE MED/97081701; Bennis A; Mehadji B; Nourredine M; Haddani J; Soulami S; Chraibi N
A psychoeducational group intervention for family members of persons with HIV/AIDS.: Fam Process. 1996 Sep;35(3):299-312. Unique Identifier : AIDSLINE MED/97265852; Pomeroy EC; Rubin A; Walker RJ; School of Social Work, University of Central Florida, Orlando 32816,; USA.; We describe a psychoeducational group intervention for family members of persons living with AIDS. The 33 family members were compared with 13 waiting-list controls in order to evaluate the effectiveness of the intervention. We focus on the practice aspects of the intervention, its development and implementation, and
Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes.: FEBS Lett. 1997 Apr 1;405(3):253-9. Unique Identifier : AIDSLINE MED/97261885; Linnevers C; Smeekens SP; Bromme D; Arris Pharmaceutical Corp., South San Francisco, CA 94080, USA.; A 750-bp fragment of a novel human cysteine protease has been identified from the dbEST databank. PCR cloning and DNA sequencing yielded a 1.38-kb full-length cDNA which encodes a polypeptide of 376 amino acids. The protein consists of a putative 21-residue signal peptide, a 106-residue propeptide and a 252-residue ma
Ion channels formed by HIV-1 Vpu: a modelling and simulation study.: FEBS Lett. 1997 Apr 1;405(3):299-304. Unique Identifier : AIDSLINE MED/97261894; Grice AL; Kerr ID; Sansom MS; Laboratory of Molecular Biophysics, University of Oxford, UK.; Vpu is an oligomeric integral membrane protein encoded by HIV-1 which forms ion channels, each subunit of which contains a single transmembrane helix. Models of Vpu channels formed by bundles of N = 4, 5 or 6 transmembrane helices have been developed by restrained molecular dynamics and refined by 100 ps simulations w
Comparison of lipid vesicle fusion induced by the putative fusion peptide of fertilin (a protein active in sperm-egg fusion) and the NH2-terminal domain of the HIV2 gp41.: FEBS Lett. 1997 Apr 1;405(3):351-5. Unique Identifier : AIDSLINE MED/97261903; Martin I; Ruysschaert JM; Laboratoire de Chimie-Physique des Macromolecules aux Interfaces; CP206/2, Universite Libre de Bruxelles, Brussels, Belgium.; imartin@ulb.ec.be; A peptide representing a putative fusion domain of fertilin, a sperm surface protein involved in sperm-egg fusion was synthesized. Its interaction with model membranes was characterized and compared with that of a synthetic peptide representing the fusion peptide of HIV-2rod gp41. The fertilin fusion peptide interacti
HIV-1 antibody testing.: Del Med J. 1997 Mar;69(3):156. Unique Identifier : AIDSLINE MED/97264705; Jean JH
AIDS in pregnancy among Indian tribal women.: Int J Gynaecol Obstet. 1997 Jan;56(1):59-60. Unique Identifier : AIDSLINE MED/97202170; Kumar RM; Rizk DE; Khurrana AK; Department of Obstetrics & Gynaecology, Faculty of Medicine and Health; Sciences, United Arab Emirates University, Al Ain, United Arab; Emirates.
Changes in lymphocyte subsets, interleukin 2, and soluble interleukin 2 receptor in old and very old age.: Gerontology. 1996;42(2):69-78. Unique Identifier : AIDSLINE MED/97012876; Rea IM; Stewart M; Campbell P; Alexander HD; Crockard AD; Morris TC; Department of Geriatric Medicine, The Queen's University of Belfast,; UK.; In this study, the changes in some of the cellular components of the immune system and the activity of the cytokine interleukin 2, important for immune activation and lymphocyte proliferation, were measured in a large cross-sectional study of all age groups including octogenarian and nonagenarian subjects. In 206 appa
Awareness of AIDS among school children in Haryana.: Indian J Public Health. 1996 Apr-Jun;40(2):38-45. Unique Identifier : AIDSLINE MED/97246357; Aggarwal AK; Kumar R; Deptt. of Community Medicine, Post Graduate Institute of Medical; Education and Research, Chandigarh.; The study is aimed to assess the existing level of knowledge of school children of 9th and 10th classes about Acquired Immune Deficiency Syndrome (AIDS). Three high schools in an urban area and three in the villages of a district of North India were included in the study. A preteste
DNA diagnosis of HTLV-I.: Intervirology. 1996;39(3):158-64. Unique Identifier : AIDSLINE MED/97211170; Yamaguchi K; Matsuoka M; Takemoto S; Tamiya S; Etoh K; Takatsuki K; Blood Transfusion Service, Kumamoto University School of Medicine,; Japan.; Human T-lymphotropic virus type I (HTLV-I) was the first retrovirus which was directly associated with adult T-cell leukemia (ATL). Infection with HTLV-I can also lead to various other diseases, e.g. HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-I uveitis, possibly via induction of immun
Virus-host interactions and diagnosis of human polyomavirus-associated disease.: Intervirology. 1996;39(3):165-75. Unique Identifier : AIDSLINE MED/97211171; Dorries K; Institut fur Virologie und Immunbiologie, Universitat Wurzburg,; Deutschland.; Persistent human polyomavirus infection is asymptomatic with limited states of virus production in the healthy individual, in immunocompromised patients, however, infection may lead to uncontrolled virus growth and fatal disease. Predominantly the CNS and in rare cases the urogenital tract are affected. During the AID
Combination drug therapy for the human immunodeficiency virus HIV) [editorial]: J Am Osteopath Assoc. 1997 Mar;97(3):128. Unique Identifier : AIDSLINE MED/97261092
Biochemical disease-free survival following 125I prostate implantation.: Int J Radiat Oncol Biol Phys. 1997 Feb 1;37(3):559-63. Unique Identifier : AIDSLINE MED/97266730; Beyer DC; Priestley JB Jr; Arizona Oncology Services, Phoenix 85013, USA.; PURPOSE: To assess the 5-year clinical and biochemical results of ultrasound-guided permanent 125I brachytherapy in early adenocarcinoma of the prostate. Biochemical disease-free survival BDFS) is reported, using PSA follow-up and is compared to the surgical and radiation therapy literature. METHODS AND MATERIALS: Fro
HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.: J Biol Chem. 1997 Mar 28;272(13):8145-8. Unique Identifier : AIDSLINE MED/97236756; Seeger M; Ferrell K; Frank R; Dubiel W; Institute of Biochemistry, Humboldt-University, Medical Faculty; Charite), Monbijoustrasse 2A, 10117 Berlin, Germany.; The proteasomal system consists of a proteolytic core, the 20 S proteasome, which associates in an ATP-dependent reaction with the 19 S regulatory complex to form the functional 26 S proteasome. In the absence of ATP, the 20 S proteasome forms a complex with the gamma-interferon-inducible 11 S regulator. Both the 20 S
Central core domain of retroviral integrase is responsible for target site selection.: J Biol Chem. 1997 Mar 28;272(13):8361-9. Unique Identifier : AIDSLINE MED/97236788; Shibagaki Y; Chow SA; Department of Molecular and Medical Pharmacology and Molecular Biology; Institute, UCLA School of Medicine, Los Angeles, California 90095,; USA.; Integration of retroviral DNA can occur into many sites on target DNA with a wide variation in preference. One factor known to affect target site selection is integrase, the viral protein required for the integration reaction. In this study, assays that measure the distribution and frequency of retroviral DNA integrat
The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR.: J Biol Chem. 1997 Mar 28;272(13):8388-95. Unique Identifier : AIDSLINE MED/97236791; Brand SR; Kobayashi R; Mathews MB; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11742,; USA.; We demonstrate that the interferon-induced, double-stranded (ds) RNA-activated kinase, PKR, is able to bind to and phosphorylate the human immunodeficiency virus type 1 (HIV-1) trans-activating protein, Tat. Furthermore, Tat can inhibit the activation and activity of the kinase. Phosphorylation of Tat by PKR is depend
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts.: J Biol Chem. 1997 Mar 28;272(13):8525-30. Unique Identifier : AIDSLINE MED/97236809; Forgacs E; Latham G; Beard WA; Prasad R; Bebenek K; Kunkel TA; Wilson SH; Lloyd RS; Sealy Center for Molecular Science, The University of Texas Medical; Branch, Galveston, Texas 77555-1071, USA.; Details of the interactions between the human immunodeficiency virus (HIV-1) reverse transcriptase and substrate DNA were probed both by introducing site-specific and stereospecific modifications into DNA and by altering the structure of potential critical residues in the polymerase. Unadducted 11-mer DNAs and 11-mer
Transcription factor activation during signal-induced apoptosis of immature CD4(+)CD8(+) thymocytes. A protective role of c-Fos.: J Biol Chem. 1997 Mar 28;272(13):8558-66. Unique Identifier : AIDSLINE MED/97236814; Ivanov VN; Nikolic-Zugic J; Immunology Program, Memorial Sloan-Kettering Cancer Center, New York,; New York 10021, USA.; Many signals that cause apoptotic cell death operate by inducing transcription and translation of other (presumably death effector) mediators, and it is well established that stimulus-induced apoptosis can often be blocked by inhibiting transcription and translation. Transcriptional regulation of apoptosis, however, i
Substituting a conserved residue of the ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase.: J Biol Chem. 1997 Mar 28;272(13):8602-10. Unique Identifier : AIDSLINE MED/97236819; Rausch JW; Le Grice SF; Department of Biochemistry, Case Western Reserve University School of; Medicine, Cleveland, Ohio 44106-4984, USA.; Alterations to the highly conserved Asp549 of the retroviral ribonuclease H (RNase H) domain were evaluated in the heterodimeric (p66/p51) reverse transcriptases of human immunodeficiency and equine infectious anemia viruses. In addition to the polymerization-dependent and -independent modes of template hydrolysis, mu
The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.: J Biol Chem. 1997 Mar 28;272(13):8671-8. Unique Identifier : AIDSLINE MED/97236827; Ruff AL; Guarnieri FG; Staveley-O'Carroll K; Siliciano RF; August JT; Department of Pharmacology and Molecular Sciences, The Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205, USA.; The lysosome-associated membrane proteins (LAMP), found in the outer membrane of lysosomes and also in a multilaminar compartment that contains major histocompatibility complex class II (MHC II) proteins, are directed to their localization by a cytoplasmic carboxyl-terminal sequence. Our studies of the immune response
Purification, structural analysis, and function of natural ATAC, a cytokine secreted by CD8(+) T cells.: J Biol Chem. 1997 Mar 28;272(13):8817-23. Unique Identifier : AIDSLINE MED/97236846; Dorner B; Muller S; Entschladen F; Schroder JM; Franke P; Kraft R; Friedl P; Clark-Lewis I; Kroczek RA; Molecular Immunology, Robert Koch-Institute, 13353 Berlin, Federal; Republic of Germany.; Recently, we identified a novel putative human cytokine expressed by activated CD8(+) T cells, which was designated ATAC activation-induced, T cell-derived, and chemokine-related; the same molecule has been identified independently as lymphotactin and single cysteine motif-1). In this report, we provide evidence that
Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA.: J Biol Chem. 1997 Apr 4;272(14):9510-6. Unique Identifier : AIDSLINE MED/97238894; Carpick BW; Graziano V; Schneider D; Maitra RK; Lee X; Williams BRG; Department of Cancer Biology, Research Institute, The Cleveland Clinic; Foundation, Cleveland, Ohio 44195, USA.; The antiviral activity of the interferon-induced, double-stranded RNA (dsRNA)-activated protein kinase (PKR) is mediated through dsRNA binding leading to PKR autophosphorylation and subsequent inhibition of protein synthesis. Previous biochemical studies have suggested that autophosphorylation of PKR occurs via a prot
Stereoisomers of deoxynucleoside 5'-triphosphates as substrates for template-dependent and -independent DNA polymerases.: J Biol Chem. 1997 Apr 4;272(14):9556-60. Unique Identifier : AIDSLINE MED/97238901; Semizarov DG; Arzumanov AA; Dyatkina NB; Meyer A; Vichier-Guerre S; Gosselin G; Rayner B; Imbach JL; Krayevsky AA; Engelhardt Institute of Molecular Biology, Russian Academy of; Sciences, 32 Vavilov Street, Moscow, 117984 Russia.; All four possible stereoisomers of dNTP with regard to deoxyribofuranose C-1 and C-4 carbon atoms were studied as substrates for several template-dependent DNA polymerases and template-independent terminal deoxynucleotidyl transferase. It was shown that DNA polymerases alpha, beta, and epsilon from human placenta an
Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm.: J Cell Sci. 1997 Feb;110 ( Pt 3):369-78. Unique Identifier : AIDSLINE MED/97209914; Arenzana-Seisdedos F; Turpin P; Rodriguez M; Thomas D; Hay RT; Virelizier JL; Dargemont C; Unite d'Immunologie Virale, Institut Pasteur, Paris, France.; I kappa B alpha tightly regulates the transcriptional activity of NF-kappa B by retaining it in the cytoplasm in an inactive form. In the present work, we report that I kappa B alpha, when expressed in the nuclear compartment, not only abrogates NF-kappa B/DNA interactions and NF-kappa B-dependent transcription, but a
Analysis of the T cell receptor V alpha repertoire in Hashimoto's thyroiditis: evidence for the restricted accumulation of CD8+ T cells in the absence of CD4+ T cell restriction.: J Clin Endocrinol Metab. 1997 Apr;82(4):1140-6. Unique Identifier : AIDSLINE MED/97255239; McIntosh RS; Watson PF; Weetman AP; Department of Medicine, University of Sheffield, Northern General; Hospital, United Kingdom. r.s.mcintosh@sheffield.ac.uk; There has been considerable interest in the possible restriction of the TCR repertoire in autoimmune disorders, because it would have important therapeutic implications. Using ribonucleic acid derived from matched peripheral blood lymphocytes (PBL), intrathyroidal lymphocytes (ITL), and CD4- and CD8-selected ITL from
Composition of plaque-associated lesions in the gingiva and the peri-implant mucosa in partially edentulous subjects.: J Clin Periodontol. 1997 Feb;24(2):119-23. Unique Identifier : AIDSLINE MED/97216690; Liljenberg B; Gualini F; Berglundh T; Tonetti M; Lindhe J; Department of Periodontology, Gothenburg University, Sweden.; The purpose of the present investigation was to study characteristics of the plaque associated lesions in the gingiva and the adjacent periimplant mucosa sampled from the same subjects. 20 partially edentulous patients (12 female and 8 male, 30-60 years of age) volunteered to participate in the study. They had all bee
Two views of risky sexual practices among northern Thai males: the Health Belief Model and the Theory of Reasoned Action.: J Health Soc Behav. 1995 Jun;36(2):195-212. Unique Identifier : AIDSLINE MED/97267814; VanLandingham MJ; Suprasert S; Grandjean N; Sittitrai W; Department of Sociology, University of Washington, Seattle 98195, USA.; mvanland@u.washington.edu; We apply the Health Belief Model (HBM) and the Theory of Reasoned Action (TRA) to an analysis of unsafe sexual practices inconsistent condom use with commercial sex workers) among men living in a high HIV-prevalence area. The empirical analysis is based primarily on a survey of sexual practices that was conducted by t
Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms.: J Immunol. 1997 Apr 15;158(8):3561-4. Unique Identifier : AIDSLINE MED/97256574; Heesen M; Berman MA; Hopken UE; Gerard NP; Dorf ME; Department of Pathology, Harvard Medical School, Boston, MA 02115,; USA.; Inspection of the intron splice junction of the mouse chemokine receptor fusin/CXC chemokine receptor R-4 (CXCR-4) revealed a potential in-frame alternative splice site in the region encoding the N-terminal ectodomain of the receptor. Both predicted splice products were detected by reverse transcriptase-PCR. Cell line
Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.: J Immunol. 1997 Apr 15;158(8):3578-86. Unique Identifier : AIDSLINE MED/97256577; Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Genetic crosses produced NOD/LtSz mice doubly homozygous for the severe combined immunodeficiency (scid) mutation and the beta2m B2m) null allele. Both NOD/LtSz-scid/scid and NOD/LtSz-scid/scid B2m(null) mice lacked mature lymphocytes and serum Ig. However, homozygosity for the B2m(null) allele also resulted in the ab
A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state.: J Immunol. 1997 Apr 15;158(8):3593-602. Unique Identifier : AIDSLINE MED/97256579; Grohmann U; Bianchi R; Ayroldi E; Belladonna ML; Surace D; Fioretti MC; Puccetti P; Department of Experimental Medicine, University of Perugia, Italy.; Ag-specific CD8+ cell responses, including delayed-type hypersensitivity in vivo and IFN-gamma production in vitro, are initiated by host immunization with P815AB, a self peptide bearing CTL epitopes and expressed by murine mastocytoma cells. Using P815AB-pulsed dendritic cells (DC) and monitoring class I-restricted s
Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.: J Immunol. 1997 Apr 15;158(8):3610-8. Unique Identifier : AIDSLINE MED/97256581; Ke Y; Pearce K; Lake JP; Ziegler HK; Kapp JA; Department of Pathology, Emory University School of Medicine, Atlanta,; GA 30322, USA.; Oral administration of Ag, over a period of several days, induces a state of tolerance that is associated with activation of CD8+ T cells that can transfer unresponsiveness to naive syngeneic hosts. We previously demonstrated that these T cells are not CTL precursors and that they inhibit responses by CD8+ CTL, as wel
Crossregulation between T helper cell (Th)1 and Th2: inhibition of Th2 proliferation by IFN-gamma involves interference with IL-1.: J Immunol. 1997 Apr 15;158(8):3666-72. Unique Identifier : AIDSLINE MED/97256588; Oriss TB; McCarthy SA; Morel BF; Campana MA; Morel PA; University of Pittsburgh Cancer Institute and Department of Medicine,; PA 15213, USA.; The Th1-derived cytokine IFN-gamma inhibits the proliferation of Th2 lymphocytes, but the mechanism of inhibition is not known. Under certain disease conditions, an established Th2-mediated immune response is undesirable and a Th1-mediated response is beneficial. However, established Th2 cells appear to be phenotypica
Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking.: J Immunol. 1997 Apr 15;158(8):3716-20. Unique Identifier : AIDSLINE MED/97256594; Tripp RA; Topham DJ; Watson SR; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; In this study we sought to better understand lymphocyte trafficking patterns and the function of secondary lymphoid organs, such as the spleen, during the generation of virus-specific T cell precursors. Treatment of mice with the Mel-14 mAb to CD62L, the lymph node homing receptor, limits trafficking of naive T cells
Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles.: J Immunol. 1997 Apr 15;158(8):3721-9. Unique Identifier : AIDSLINE MED/97256595; Valenzuela A; Blanco J; Callebaut C; Jacotot E; Lluis C; Hovanessian AG; Franco R; Department of Biochemistry and Molecular Biology, Faculty of; Chemistry, University of Barcelona, Catalonia, Spain.; CD26, known to be the adenosine deaminase (ADA)-binding protein, has been implicated in HIV infection. Several studies have revealed a correlation between depletion of CD4+/CD26+ T lymphocytes, increased serum levels of ADA, and the evolution of AIDS in infected individuals. We show that in human B and T cell lines, i
Immunoregulatory idiotypes stimulate T helper 1 cytokine responses in experimental Schistosoma mansoni infections.: J Immunol. 1997 Apr 15;158(8):3800-4. Unique Identifier : AIDSLINE MED/97256605; Montesano MA; Freeman GL Jr; Secor WE; Colley DG; Federal University of Juiz de Fora, Brazil.; Inbred male CBA/J mice with chronic Schistosoma mansoni infections develop two distinct syndromes. Hypersplenomegaly syndrome (HSS) demonstrates pathologic similarities to the hepatosplenic form of chronic human schistosomiasis, and moderate splenomegaly syndrome (MSS) resembles the asymptomatic intestinal form. Immun
Destruction of follicular dendritic cells during chronic visceral leishmaniasis.: J Immunol. 1997 Apr 15;158(8):3813-21. Unique Identifier : AIDSLINE MED/97256607; Smelt SC; Engwerda CR; McCrossen M; Kaye PM; Department of Medical Parasitology, London School of Hygiene and; Tropical Medicine, United Kingdom.; Follicular dendritic cells (FDCs) play a pivotal role in the germinal center (GC) response and in the development and regulation of B lymphocytes. Pathologic changes in GCs and a loss of FDCs have previously been noted in various viral infections, notably HIV-1. However, such changes have not been formally described i
Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes.: J Immunol. 1997 Apr 15;158(8):3947-58. Unique Identifier : AIDSLINE MED/97256624; Ahlers JD; Dunlop N; Alling DW; Nara PL; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section Metabolism; Branch, National Cancer Institute, National Institutes of Health,; Bethesda, MD 20892, USA.; To enhance and steer immune responses to synthetic peptide vaccines toward selected functional types and to understand the cooperative action of cytokines in fine-tuning the immune response, we attempted to influence the in vivo cytokine environment by delivering cytokines directly to the microenvironment in which the
HIV-induced T cell syncytia are self-perpetuating and the primary cause of T cell death in culture.: J Immunol. 1997 Apr 15;158(8):3996-4007. Unique Identifier : AIDSLINE MED/97256630; Sylwester A; Murphy S; Shutt D; Soll DR; Department of Biological Sciences, University of Iowa, Iowa City; 52242, USA.; Prior studies suggested that induced fusion in T cell cultures infected with syncytium-inducing HIV was not the primary cause of T cell death. However, these studies failed to assess the contribution of fusion in terms of syncytium volume, rather than syncytium frequency. This question has been reassessed by monitorin
Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12.: J Immunol. 1997 Apr 15;158(8):4008-13. Unique Identifier : AIDSLINE MED/97256631; Tsuji T; Hamajima K; Fukushima J; Xin KQ; Ishii N; Aoki I; Ishigatsubo Y; Tani K; Kawamoto S; Nitta Y; Miyazaki J; Koff WC; Okubo T; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Kanazawa-ku, Yokohama, Japan.; Previous investigations have demonstrated that CTL may play an important role in suppressing the disease progression of HIV infection. In this study, we inoculated mice with IL-12 expression plasmid together with plasmid-encoding HIV-1 envelope to enhance CTL activity by activating a Th1-type response. The results of
Chemokine receptors as fusion cofactors for human immunodeficiency virus type 1 (HIV-1).: Immunol Res. 1997 Feb;16(1):15-28. Unique Identifier : AIDSLINE MED/97200271; Doranz BJ; Berson JF; Rucker J; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; CD4 is the primary cellular receptor for human immunodeficiency virus type 1 (HIV-1), but is not sufficient for entry of HIV-1 into cells. After a decade-long search, the cellular coreceptors that HIV-1 requires in conjunction with CD4 have been identified as members of the chemokine receptor family of seven-transmemb
Unique CD8+ T cell-rich lymphoid aggregates in human uterine endometrium.: J Leukoc Biol. 1997 Apr;61(4):427-35. Unique Identifier : AIDSLINE MED/97256388; Yeaman GR; Guyre PM; Fanger MW; Collins JE; White HD; Rathbun W; Orndorff KA; Gonzalez J; Stern JE; Wira CR; Department of Microbiology, Dartmouth Medical School, Lebanon, New; Hampshire 03756, USA.; Using confocal scanning laser microscopy of viable tissue sections, we have demonstrated organized lymphoid aggregates LA), that have a unique structure, in the stratum basalis of uterine endometrium. These LA consist of a core of B cells surrounded by more numerous T cells and an outer halo of monocytes/ macrophages.
Different cytokine profiles released by CD4+ and CD8+ tumor-draining lymph node cells involved in mediating tumor regression.: J Leukoc Biol. 1997 Apr;61(4):507-16. Unique Identifier : AIDSLINE MED/97256397; Aruga A; Aruga E; Cameron MJ; Chang AE; Department of Surgery, University of Michigan, Ann Arbor 48109, USA.; We have previously demonstrated that the growth of weakly immunogenic murine sarcomas leads to the induction of immunologically specific pre-effector cells in tumor-draining lymph nodes (TDLN). The in vitro activation of TDLN cells with anti-CD3 monoclonal antibodies (mAbs) and interleukin-2 (
Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1.: J Leukoc Biol. 1997 Apr;61(4):533-8. Unique Identifier : AIDSLINE MED/97256401; Guerette B; Moisset PA; Huard C; Tardif F; Gravel C; Tremblay JP; Centre de Recherche en Neurobiologie, Universite Laval and Hopital; del'Enfant-Jesus, Quebec, Canada.; First-generation replication-defective adenoviruses have been reported to lead to transient reporter gene expression due to a specific immune reaction involving T and B lymphocytes. Some recent reports have also demonstrated the presence of a nonspecific inflammatory reaction involving macrophages and neutrophils afte
Prevalence of anti-vif antibodies in HIV-1 infected individuals assessed using recombinant baculovirus expressed vif protein.: J Med Virol. 1997 Mar;51(3):139-44. Unique Identifier : AIDSLINE MED/97218347; O'Neil C; Lee D; Clewley G; Johnson MA; Emery VC; Department of Virology, Royal Free Hospital and School of Medicine,; London, United Kingdom.; A 630 base pair fragment of the HIV-1 genome encompassing the entire vif open reading frame has been produced by the polymerase chain reaction and cloned into the baculovirus transfer vector pAcYM1. Extracts from insect cells infected with a recombinant baculovirus expressing the HIV-1 vif gene product were used in a
Comparison of antibody responses to different forms of HIV-1 core antigens by epitope mapping.: J Med Virol. 1997 Mar;51(3):145-51. Unique Identifier : AIDSLINE MED/97218348; Truong C; Brand D; Mallet F; Roingeard P; Barin F; Laboratorie de Virologie, Centre National de la Recherche; Scientifique, URA 1334, Centre Hospitalier Universitaire Bretonneau,; Tours, France.; The specificity of antibodies to HIV-1 capsid (p24CA) and matrix p17MA) proteins, produced in mice against unprocessed immature assembled polyprotein (wild-type p55 virus-like particles or chimeric p55 virus-like particles) or against the monomeric mature form (rp24CA/rp17MA), was analyzed by a microplate epitope mapp
Virologic, immunologic, and clinical follow-up of a couple infected by the human immunodeficiency virus type one, group O.: J Med Virol. 1997 Mar;51(3):202-9. Unique Identifier : AIDSLINE MED/97218356; Nkengasong JN; Fransen K; Willems B; Karita E; Vingerhoets J; Kestens L; Colebunders R; Piot P; van der Groen G; Department of Infection and Immunity, Institute of Tropical Medicine,; Antwerp, Belgium.; The pathogenic course (virologic, immunologic, and clinical changes) of infection due to human immunodeficiency virus type one (HIV-1) group O viruses is unknown at present. To address this issue, serial HIV-1 isolates from a married couple (patients A and B) infected with a group O virus were analyzed to determine th
Primary T-cell lymphoma of the brain in acquired immunodeficiency syndrome: case report.: J Neurooncol. 1997 Feb;31(3):267-71. Unique Identifier : AIDSLINE MED/97202328; Bindal AK; Blisard KS; Melin-Aldama H; Warnick RE; Department of Neurosurgery, University of Cincinnati Medical Center,; Ohio, USA.; In patients with acquired immunodeficiency syndrome (AIDS), primary central nervous system lymphoma (PCNSL) is now the most common noninfectious intracranial mass lesion and the fourth leading cause of death. Most cases of PCNSL are B-cell in origin and are only rarely of T-cell origin. We report the first complete cl
Combination chemotherapy in the treatment of Kaposi sarcoma in a child infected with human immunodeficiency virus [letter]: J Pediatr. 1997 Apr;130(4):675. Unique Identifier : AIDSLINE MED/97262589; Mastroianni A; Coronado O; Di Bari MA; Chiodo F
In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.: J Pharmacol Exp Ther. 1997 Apr;281(1):369-75. Unique Identifier : AIDSLINE MED/97256678; Takasawa K; Terasaki T; Suzuki H; Sugiyama Y; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, The; University of Tokyo, Bunkyo-ku, Japan.; By analyzing the amount of ligand remaining in the brain after microinjection into the brain cortex, the apparent efflux rate constants (Keff) of 3 -azido-3 -deoxythymidine ( AZT ) and 2 ,3 -dideoxyinosine (DDI) across the blood-brain barrier at low con
JC virus detection in the cerebrospinal fluid of AIDS patients with progressive multifocal leucoencephalopathy and monitoring of the antiviral treatment by a PCR method.: J Med Microbiol. 1997 Mar;46(3):256-9. Unique Identifier : AIDSLINE MED/97271982; Matsiota-Bernard P; De Truchis P; Gray F; Flament-Saillour M; Voyatzakis E; Nauciel C; Laboratoire de Microbiologie, Hopital Raymond Poincare, Garches,; France.; Twenty-four cerebrospinal fluid (CSF) samples from 19 AIDS patients with neurological signs were analysed by the polymerase chain reaction (PCR) for the presence of JC virus (JCV). Eleven of the 19 patients tested presented with progressive multifocal leucoencephalopathy (PML). Two specific JCV target sequences were u
Differentiation of strains of Mycoplasma fermentans from various sources by pyrolysis mass spectrometry.: J Med Microbiol. 1997 Apr;46(4):348-53. Unique Identifier : AIDSLINE MED/97274026; Hannan PC; Kearns AM; Sisson PR; Freeman R; Mycoplasma Experience Ltd, Reigate, Surrey.; Mycoplasma fermentans has attracted much interest both as a cofactor for the progression of AIDS and as a pathogenic agent in non-AIDS related diseases. Previous studies with serological and genetic techniques suggest that M. fermentans represents a homogeneous group of organisms, with no significant differences ident
Frequent expression of interleukin-9 mRNA and infrequent involvement of interleukin-9 in proliferation of primary adult T-cell leukemia cells and HTLV-I infected T-cell lines.: Leuk Res. 1997 Mar;21(3):211-6. Unique Identifier : AIDSLINE MED/97265228; Matsushita K; Arima N; Ohtsubo H; Fujiwara H; Hidaka S; Fukumori J; Tanaka H; First Department of Internal Medicine, Kagoshima University,; Sakuragaoka, Japan.; To examine the possibility that interleukin-9 (IL-9) may be involved in oncogenesis and the proliferation of adult T-cell leukemia (ATL) cells, we examined the expression of IL-9 mRNA and growth response to IL-9 in five human T-lymphotropic virus type-I HTLV-I) infected T-cell lines and in primary leukemia cells in pe
[Tuberculosis. An especially contagious disease (editorial; comment)]: Med Clin (Barc). 1997 Mar 15;108(10):382-4. Unique Identifier : AIDSLINE MED/97244827; Mallolas J; Soriano E
[A study of 30 patients with bacteremia due to Campylobacter spp.]: Med Clin (Barc). 1997 Mar 8;108(9):336-40. Unique Identifier : AIDSLINE MED/97241030; Font C; Cruceta A; Moreno A; Miro O; Coll-Vinent B; Almela M; Mensa J; Servicio de Medicina Interna General, Hospital Clinic i Provincial,; Barcelona.; BACKGROUND: To get better knowledge about clinical and bacteriological features in Campylobacter spp. bacteremia. PATIENTS AND METHODS: Over a period of 8 years (1987-1994) we prospectively analyzed underlying diseases, predisposing factors, clinical manifestations, complications and outcome of patients with Campyloba
[Non-typhoid salmonellosis and human immunodeficiency virus (HIV) infection]: Med Clin (Barc). 1997 Mar 8;108(9):349-55. Unique Identifier : AIDSLINE MED/97241033; Ramos JM; Fernandez Guerrero ML; Servicio de Microbiologia, Fundacion Jimenez Diaz, Universidad; Autonoma, Madrid.
[Oophoritis due to cytomegalovirus in a female AIDS patient letter)]: Med Clin (Barc). 1997 Mar 8;108(9):357-8. Unique Identifier : AIDSLINE MED/97241036; Ortiz-Rey JA; Touza F; Perez-Valcarcel J; Perez-Villanueva J
Necrotizing external otitis in patients with AIDS.: Laryngoscope. 1997 Apr;107(4):456-60. Unique Identifier : AIDSLINE MED/97265436; Ress BD; Luntz M; Telischi FF; Balkany TJ; Whiteman ML; Department of Otolaryngology, University of Miami School of Medicine,; Florida 33101, U.S.A.; In a retrospective review of seven patients with AIDS who were diagnosed with necrotizing external otitis between 1990 and 1995, it was found that the presentation of necrotizing external otitis in patients with AIDS differed from the classic description of malignant external otitis in several respects. The patient po
Influence of the level of dietary lipid intake and maximal exercise on the immune status in runners.: Med Sci Sports Exerc. 1997 Mar;29(3):333-44. Unique Identifier : AIDSLINE MED/97227469; Venkatraman JT; Rowland JA; Denardin E; Horvath PJ; Pendergast D; Department of Oral Biology, State University of New York at Buffalo; 14214, USA. jtv@acsu.buffalo.edu; Chronic exercise and high fat diets are associated with immune suppression. This study compares cellular immune responses at rest and after maximal exercise in runners after eating diets comprised of 17% low fat (LF), 32% medium fat (MF), and 41% high fat (HF) (4 wk each). VO2max increased significantly from the 17% t
[HIV seroprevalence in adults with pulmonary tuberculosis in Yaounde, Cameroon]: Med Trop (Mars). 1996;56(4):357-60. Unique Identifier : AIDSLINE MED/97266929; Kuaban C; Bercion R; Service de Pneumologie, Hopital Jamot, Yaounde, Cameroun.; To determine current seroprevalence of HIV in adult patients with pulmonary tuberculosis in Yaounde, Cameroon , we prospectively studied 671 consecutive patients aged 15 years or more, admitted to the chest clinic of Jamot Hospital from July 1994 to December 1995. All sera were sc
[Oncology '96]: Med Klin. 1997 Feb 15;92(2):83-100. Unique Identifier : AIDSLINE MED/97208394; Hartmann F; Pfreundschuh M; Medizinische Klinik und Poliklinik, Universitat des Saarlandes,; Homburg (Saar).
A lesson in AIDS education.: Mo Med. 1997 Apr;94(4):163. Unique Identifier : AIDSLINE MED/97257271; Kakarlapudi V
Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides.: Mol Pharmacol. 1997 Apr;51(4):567-75. Unique Identifier : AIDSLINE MED/97260500; Mazumder A; Uchida H; Neamati N; Sunder S; Jaworska-Maslanka M; Wickstrom E; Zeng F; Jones RA; Mandes RF; Chenault HK; Pommier Y; Division of Basic Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; Retroviral integrases are essential for viral replication and represent an attractive chemotherapeutic target. In the current study, we demonstrated the activity of micromolar concentrations of dinucleotides against human immunodeficiency virus type 1 HIV-1), HIV type 2 (HIV-2), simian immunodeficiency virus, and feli
Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group.: N Engl J Med. 1997 May 8;336(19):1337-42. Unique Identifier : AIDSLINE MED/97263434; Shearer WT; Quinn TC; LaRussa P; Lew JF; Mofenson L; Almy S; Rich K; Handelsman E; Diaz C; Pagano M; Smeriglio V; Kalish LA; Department of Pediatrics, Baylor College of Medicine, Houston, TX,; USA.; BACKGROUND: There are only limited data on human immunodeficiency virus type 1 (HIV-1) RNA in perinatally infected infants. Understanding the dynamics of HIV-1 infection and its relation to disease progression may help identify opportunities for effective antiviral treatment in infected infants. METHODS: We obtained p
Combination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection.: N Engl J Med. 1997 May 8;336(19):1343-9. Unique Identifier : AIDSLINE MED/97263435; Luzuriaga K; Bryson Y; Krogstad P; Robinson J; Stechenberg B; Lamson M; Cort S; Sullivan JL; Department of Pediatrics, University of Massachusetts Medical School,; Worcester 01605, USA.; BACKGROUND: In infants and children with maternally acquired human immunodeficiency virus type 1 (HIV-1) infection, treatment with a single antiretroviral agent has limited efficacy. We evaluated the safety and efficacy of a three-drug regimen in a small group of maternally infected infants. METHODS: Zidovudine, didan
Mother-to-infant transmission of HIV [letter; comment]: N Engl J Med. 1997 May 8;336(19):1392. Unique Identifier : AIDSLINE MED/97263454; Minkoff H; Bauer TA
Barriers to health-seeking behaviors for women infected with HIV.: Nursingconnections. 1996 Fall;9(3):5-17. Unique Identifier : AIDSLINE MED/97264999; Sowell RL; Seals B; Moneyham L; Guillory J; Demi A; Cohen L; Department of Administrative and Clinical Nursing, University of South; Carolina, Columbia, USA.; There is a growing need to develop services for women with human immunodeficiency virus (HIV) infection, despite the reluctance of many to seek help. Yet, there is limited knowledge of the forces that act as barriers to health-seeking behaviors among these women. In the analysis of this focus group study of 46 women w
Evaluation of renal acidification in HIV-infected patients with hypergammaglobulinemia.: Nephron. 1997;75(2):196-200. Unique Identifier : AIDSLINE MED/97193963; Seux-Levieil ML; Joly V; Yeni P; Carbon C; Blanchet F; Service de Medecine interne, Hospitalo-Universitaire Bichat-Claude; Bernard, Paris, France.; Distal renal tubular acidosis has been reported in several diseases associated with hypergammaglobulinemia, particularly Sjogren s syndrome. Since HIV infection is now a common cause of hypergammaglobulinemia, we evaluated renal acidification under basal and dynamic conditions in 8 asymptomatic HIV-seropositive subjec
Health promotion in HIV: perspectives for practitioners [news]: Nurse Pract. 1997 Feb;22(2):114-6, 119, 125. Unique Identifier : AIDSLINE MED/97208085; Kitten JH
Gay, lesbian, and bisexual adolescents: providing esteem-enhancing care to a battered population.: Nurse Pract. 1997 Feb;22(2):94, 99, 103 passim. Unique Identifier : AIDSLINE MED/97208083; Nelson JA; Elmhurst Hospital Center, Queens, N.Y., USA.; Suicide, HIV infection, violent victimization, homelessness, and substance use are known to affect gay (gay males, lesbians, and bisexual persons of both genders) youths at disproportionately high rates. This article explores the difficulties gay youths experience in this society specific to their sexual orientation.
Risk factors for cotton-wool spots and for cytomegalovirus retinitis in patients with human immunodeficiency virus infection.: Ophthalmology. 1995 Dec;102(12):1860-4. Unique Identifier : AIDSLINE MED/97252830; Spaide RF; Gaissinger A; Podhorzer JR; Department of Ophthalmology, St. Vincent's Hospital and Medical Center; of New York, New York, USA.; PURPOSE: To investigate the risk factors for cotton-wool spots and for cytomegalovirus retinitis in patients with human immunodeficiency virus infection (HIV). METHODS: A cross-sectional study was performed on 453 consecutive male patients with a positive serodiagnosis for HIV. The
Combined intravenous ganciclovir and foscarnet for children with recurrent cytomegalovirus retinitis.: Ophthalmology. 1995 Dec;102(12):1865-70. Unique Identifier : AIDSLINE MED/97252831; Walton RC; Whitcup SM; Mueller BU; Lewis LL; Pizzo PA; Nussenblatt RB; Laboratory of Immunology, National Eye Institute, National Institutes; of Health, Bethesda, USA.; PURPOSE: Children with the acquired immune deficiency syndrome AIDS) and cytomegalovirus ( CMV ) retinitis may not complain of symptoms despite the presence of advanced sight-threatening disease. Although little data exist rega
The kinetics of immunological responses to microfilariae in a murine host: experimental and mathematical studies.: Parasitology. 1997 Mar;114 ( Pt 3):237-43. Unique Identifier : AIDSLINE MED/97229427; Rhodes CJ; Folkard SG; Bianco AE; Anderson RM; Department of Zoology, University of Oxford, UK.; chris.rhodes@zoology.oxford.ac.uk; We present a mathematical model which is used to interpret the dynamics of the immunological response of a mouse host to infection with the filarial worm Onchocerca lienalis. The model mimics changes in worm burden over time post-infection and after reinfection and its behaviour provides a good description of experime
Mispair extension fidelity of human immunodeficiency virus type 1 reverse transcriptases with amino acid substitutions affecting Tyr115.: Nucleic Acids Res. 1997 Apr 1;25(7):1383-9. Unique Identifier : AIDSLINE MED/97214031; Martin-Hernandez AM; Gutierrez-Rivas M; Domingo E; Menendez-Arias L; Centro de Biologia Molecular 'Severo Ochoa', Consejo Superior de; Investigaciones Cientificas-Universidad Autonoma de Madrid, 28049; Cantoblanco, Madrid, Spain.; The role of Tyr115 of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) in the mispair extension fidelity of DNA dependent DNA synthesis was analysed by using a series of 15 mutant enzymes with substitutions at Tyr115. Their kinetic parameters for elongation using homopolymeric RNA-DNA and heteropol
The prison nurse [interview]: Nurs Times. 1997 Feb 26-Mar 4;93(9):12. Unique Identifier : AIDSLINE MED/97250074; MacGregor A
Aid-related risks.: Nurs Times. 1997 Feb 26-Mar 4;93(9):14-5. Unique Identifier : AIDSLINE MED/97250075; Porter R
Clinics in a dilemma over HIV partner notification [news]: Nurs Times. 1997 Feb 26-Mar 4;93(9):49. Unique Identifier : AIDSLINE MED/97250085
[Observance during clinical trials in HIV infection. A discontinuity between patient history and trial logic]: Presse Med. 1997 Mar 15;26(8):358-65. Unique Identifier : AIDSLINE MED/97267722; Munzenberger N; Cassuto JP; Gastaut JA; Souville M; Morin M; Moatti JP; INSERM U379 Epidemiologie et Sciences sociales appliquees a; l'Innovation medicale, Marseille.; OBJECTIVES: Describe and analyze the processes which lead to patient compliance or non-compliance in HIV treatment trials and to develop a model for strategies aimed at improving compliance and facilitating inclusion (adherence) of these patients. METHOD: First, 12 members of the health care teams at two day care clin
Light and electron microscopy study of carbohydrate antigens found in the electron-lucent layer of Pneumocystis carinii cysts.: Parasitol Res. 1997;83(2):177-84. Unique Identifier : AIDSLINE MED/97191759; Roth A; Wecke J; Karsten V; Janitschke K; Institute of Microbiology and Immunology, Hospital of; Zehlendorf-Heckeshorn, Berlin, Germany.; The localization and biochemical nature of antigens found in the electron-lucent layer (ELL) of Pneumocystis carinii cysts using polyclonal rabbit antibodies are described. These antigens, specific for the cystic stages of the parasite, were shared by organisms from different hosts, suggesting that they represent func
Free energy perturbation studies on binding of A-74704 and its diester analog to HIV-1 protease.: Protein Eng. 1996 Sep;9(9):767-71. Unique Identifier : AIDSLINE MED/97042944; Rao BG; Murcko MA; Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139, USA.; Free energy simulations have been employed to rationalize the binding differences between A-74704, a pseudo C2-symmetric inhibitor of HIV-1 protease and its diester analog. The diester analog inhibitor, which misses two hydrogen bonds with the enzyme active site, is surprisingly only 10-fold weaker. The calculated fre
Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway.: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3178-82. Unique Identifier : AIDSLINE MED/97250510; Brigino E; Haraguchi S; Koutsonikolis A; Cianciolo GJ; Owens U; Good RA; Day NK; Department of Pediatrics, University of South Florida, St. Petersburg; 33701, USA.; HIV-1 Nef protein shares a significant homology with the immunosuppressive and highly conserved retroviral transmembrane protein p15E. In the present study, extracellular Nef protein is shown to induce interleukin (IL)-10 mRNA expression in human peripheral blood mononuclear cells as well as in cells of H9 T and U937
In differentiated CD4+ T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent.: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3189-94. Unique Identifier : AIDSLINE MED/97250512; Hu-Li J; Huang H; Ryan J; Paul WE; Laboratory of Immunology, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA.; CD4+ T cells from T cell receptor transgenic mice that have been vigorously primed to be interleukin (IL)-4 producers (T(H2) cells) are capable of producing IL-4 even if restimulated in the absence of IL-4 and in the presence of IL-12. T cells vigorously primed in the absence of IL-4 (T(H1) cells) fail to produce IL-4
Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus.: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3314-9. Unique Identifier : AIDSLINE MED/97250534; Saron MF; Fayolle C; Sebo P; Ladant D; Ullmann A; Leclerc C; Unite d'Histopathologie-Virologie Experimentale, Institut Pasteur,; Paris, France.; The elucidation of the mechanisms of antigen presentation by major histocompatibility complex class I molecules has stimulated the search for nonreplicative vectors that could deliver CD8+ T cell epitopes to the cytosol of antigen-presenting cells to trigger the activation of specific cytotoxic T lymphocytes (CTLs) in
Development of a novel anti-HIV-1 agent from within: effect of chimeric Vpr-containing protease cleavage site residues on virus replication.: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3346-51. Unique Identifier : AIDSLINE MED/97250540; Serio D; Rizvi TA; Cartas M; Kalyanaraman VS; Weber IT; Koprowski H; Srinivasan A; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, PA 19107, USA.; Effective antiviral agents will be of great value in controlling virus replication and delaying the onset of HIV-1-related disease symptoms. Current therapy involves the use of antiviral agents that target the enzymatic functions of the virus, resulting in the emergence of resistant viruses to these agents, thus lower
Responses to loss and bereavement in HIV.: Prof Nurse. 1996 Oct;12(1):21-4. Unique Identifier : AIDSLINE MED/97274559; Maxwell N; Terrence Higgins Trust, London.; The emotional needs of people with HIV are as important as their physical needs. Family and friends often have similar needs to those of the patient. Nurses should help to prepare patients, family, friends and themselves for the patient s eventual death. It is important for nurses to have sources of support and referr
The prevalence of HIV and AIDS in older people.: Prof Nurse. 1996 Dec;12(3):193-5. Unique Identifier : AIDSLINE MED/97274582; Tordoff C; Department of Nursing Studies, University of Edinburgh.; HIV/AIDS is now a world-wide problem affecting individuals of all ages and from many backgrounds. Health-care professionals may not give sufficient consideration to the possibility of HIV infection in older people. Misdiagnosis of AIDS in older people has serious implications for care and infection risks.
[Depressive affect and surrogate markers in HIV infected patients]: Psychother Psychosom Med Psychol. 1997 Jan;47(1):34-40. Unique Identifier : AIDSLINE MED/97206702; Brauchli P; Zeier H; Institut fur Verhaltenswissenschaft ETH Zurich.; The present study investigates whether there is a relationship between subjective well-being and the change of immune markers in HIV-infected subjects. Twenty-one HIV-infected persons completed questionnaires. Immune markers (CD4-percentage and CD4/CD8-ratio) were measured at the beginning of the study, after 8 months
Further validation of the AIDS Attitude Scale.: Res Nurs Health. 1997 Apr;20(2):161-7. Unique Identifier : AIDSLINE MED/97255399; Froman RD; Owen SV; Center for Nursing Research, School of Nursing, University of; Connecticut, Storrs 06269-2026, USA.; The AIDS Attitude Scale (AAS) is a self-report measure of attitude toward persons with AIDS. Since its introduction in 1992, the AAS has been used in over 30 research studies. Initial psychometric estimates of reliability and validity for the scale were supportive. This report summarizes emerging psychometric data fro
Lymphocyte activation markers in peripheral blood before and after natural exposure to allergen in asthmatic patients.: Respiration. 1997;64(1):45-9. Unique Identifier : AIDSLINE MED/97197414; Majori M; Piccoli ML; Melej R; Pileggi V; Pesci A; Istituto di Clinica delle Malattie dell'Apparato Respiratorio; dell'Universita di Parma, Italia.; Activated T cells and their cytokine products are involved in the pathogenesis of asthma. However, little is known about changes in circulating T cell subsets in allergic asthma during natural exposure to allergens. We examined whether natural allergen exposure of patients with atopic asthma is associated, in vivo, wi
Lymphoproliferative disorders associated with congenital immunodeficiencies.: Semin Diagn Pathol. 1997 Feb;14(1):35-47. Unique Identifier : AIDSLINE MED/97197448; Elenitoba-Johnson KS; Jaffe ES; Laboratory of Pathology, National Cancer Institute, Bethesda, MD; 20892-1500, USA.; This report reviews the clinicopathologic, immunologic, and molecular biological features of the congenital immunodeficiencies and their associated lymphoproliferative disorders (LPD) including cases presented at the Third Slide Workshop of the Society of Hematopathology, held in Duarte California, in October 1995. Th
Human immunodeficiency virus-related lymphoid proliferations.: Semin Diagn Pathol. 1997 Feb;14(1):48-53. Unique Identifier : AIDSLINE MED/97197449; Said JW; Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA,; USA.; Human immunodeficiency virus (HIV) infection is associated with a range of lymphoid alterations from generalized lymphadenopathy to abnormal lymphoid proliferations and malignant lymphomas. Special characteristics of lymphoid proliferation are seen in the lungs and thymus of children infected with HIV. HIV-related lym
Kaposi's sarcoma-associated herpesvirus: a lymphotropic human herpesvirus associated with Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.: Semin Diagn Pathol. 1997 Feb;14(1):54-66. Unique Identifier : AIDSLINE MED/97197450; Cesarman E; Knowles DM; Department of Pathology, New York Hospital, Cornell Medical Center; 10021, USA.; Despite extensive epidemiological evidence suggesting that Kaposi s sarcoma (KS) has an infectious origin, a specific viral association with KS had not been documented until recently, when two novel DNA fragments were identified in KS lesional tissue from a patient with the acquired immunodeficiency syndrome AIDS). Th
Molecular pathology of acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma.: Semin Diagn Pathol. 1997 Feb;14(1):67-82. Unique Identifier : AIDSLINE MED/97197451; Knowles DM; Department of Pathology, New York Hospital, Cornell Medical Center,; New York 10021, USA.; The incidence of non-Hodgkin s lymphoma is greatly increased in human immunodeficiency virus (HIV)-infected individuals. Most are clinically aggressive B-cell lymphomas exhibiting Burkitt-type, immunoblastic or large-cell morphology. Approximately 80% arise systemically (nodal or e
Pain in human immunodeficiency virus disease.: Semin Oncol Nurs. 1997 Feb;13(1):36-41. Unique Identifier : AIDSLINE MED/97200500; Newshan G; AIDS Center Program, St Vincent's Hospital, New York, NY, USA.; OBJECTIVES: To review the prevalence and etiology of pain in persons with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), and issues and considerations for pain management in this patient population. DATA SOURCES: Research studies, review articles, and books related to pain in persons with
[Mono- ad polychemotherapy in HIV infection]: Rev Prat. 1997 Feb 15;47(4):357-60. Unique Identifier : AIDSLINE MED/97269389; Joly V; Yeni P; Hopital Bichat-Claude Bernard, Paris.
Characterization of Chlamydia pneumoniae antigens using human T cell clones.: Scand J Immunol. 1997 Apr;45(4):378-84. Unique Identifier : AIDSLINE MED/97259305; Halme S; Saikku P; Surcel HM; National Public Health Institute, Oulu, Finland.; Chlamydia pneumoniae infection is followed by the development of antigen-specific cell-mediated immunity (CMI), which is detectable as a positive lymphocyte proliferation (LP) response to C. pneumoniae elementary body (EB) antigen, but the proteins inducing the T cell activation are not known. In the present work the
Lack of correlation between membrane CD30 expression and cytokine secretion pattern in allergen-primed naive cord blood T-cell lines and clones.: Scand J Immunol. 1997 Apr;45(4):417-22. Unique Identifier : AIDSLINE MED/97259310; Spinozzi F; Agea E; Piattoni S; Falini B; Grignani F; Bertotto A; Department of Internal Medicine, University of Perugia School of; Medicine, Italy.; Various surface molecules are expressed by activated T cells. Among them, the CD30 antigen has been proposed as a reproducible marker that identifies a subset of differentiated and/or activated T lymphocytes that produce T helper (Th)-2-type cytokines, i.e. interleukin (IL)-4 and IL-5. However, because CD30 has mainly
AIDS: a justifiable share [news]: Science. 1997 Apr 18;276(5311):345. Unique Identifier : AIDSLINE MED/97275013; Cohen J
Effect of transmembrane and cytoplasmic domains of IgE on the IgE response.: Science. 1997 Apr 18;276(5311):409-11. Unique Identifier : AIDSLINE MED/97258942; Achatz G; Nitschke L; Lamers MC; Max-Planck-Institut fur Immunbiologie, Stubeweg 51, D-79108 Freiburg,; Germany.; B cells use immunoglobulin M (IgM) and IgD as antigen receptors, but after contact with antigen they can switch and use IgG, IgA, or IgE. In mice lacking the transmembrane and cytoplasmic domains of IgE, serum IgE is reduced by more than 95 percent and, after immunization, specific responses are negligible. In mice la
Contributions of protein structure-based drug design to cancer chemotherapy.: Semin Oncol. 1997 Apr;24(2):164-72. Unique Identifier : AIDSLINE MED/97275926; Jackson RC; Agouron Pharmaceuticals, Inc, San Diego, CA 92121, USA.; Protein structure-based drug design (SBDD) uses a knowledge of the molecular structure of a target macromolecule, normally obtained by x-ray crystallography, to design potent, selective inhibitors. This technique has played a major role in the design of a number of drugs that have progressed to clinical trials. Most o
Shattered assumptions: time and the experience of long-term HIV positivity.: Soc Sci Med. 1997 Mar;44(5):561-71. Unique Identifier : AIDSLINE MED/97185083; Davies ML; Department of Psychiatry, Faculty of Medicine, Sheffield University,; UK.; This paper elucidates one of the main existential problems faced by people living with an HIV positive diagnosis-the disruption in their routine orientation towards time and the way in which this has the capacity to affect their lives more generally. Drawing upon research with people who have been living with an HIV p
Refocusing the lens: epidemiologic transition theory, mortality differentials, and the AIDS pandemic.: Soc Sci Med. 1997 Mar;44(5):609-21. Unique Identifier : AIDSLINE MED/97185088; Gaylin DS; Kates J; Lewin Group, Fairfax, VA 22031, USA.; The epidemiologic transition theory presented first by Omran [Omram. A. R. (1971) The epidemiologic transition: a theory of the epidemiology of population change, Mildbank Quarterly 49(4), 509-538] was designed to explain global trends in the dynamic relationship between epidemiological phenomena and demographic chang
Toxoplasma infection in healthy persons and in patients with HIV or ocular disease.: Southeast Asian J Trop Med Public Health. 1995 Dec;26(4):655-8. Unique Identifier : AIDSLINE MED/97206452; Wongkamchai S; Rungpitaransi B; Wongbunnate S; Sittapairochana C; Department of Clinical Pathology, Faculty of Medicine, Mahidol; University, Bangkok, Thailand.; Toxoplasma infection is associated with acquired immune deficiency syndrome (AIDS), pregnancy, chorioretinitis, etc. Since the number of AIDS patients is increasing rapidly in Thailand and there are few reports about T. gondii immune status in this country. Toxoplasma-specific Ig
Perinatal HIV infections in Thailand.: Southeast Asian J Trop Med Public Health. 1995 Dec;26(4):659-63. Unique Identifier : AIDSLINE MED/97206453; Srison D; Thisyakorn U; Paupunwatana S; Chotpitayasunondh T; Kanchanamayul V; Limpitikul W; Panpitpat C; Chao Phya Abhai Bhu Bejhr Hospital, Prachinburi, Thailand.; A collaborative study group of researchers from seven hospitals from all regions of Thailand was formed to collect information on children born to HIV-infected mothers since the beginning of the first hospital case until the end of June 1994. The study conducted to verify the sta
Microsporidium and Cyclospora in human stools in Chiang Mai, Thailand.: Southeast Asian J Trop Med Public Health. 1995 Dec;26(4):799-800. Unique Identifier : AIDSLINE MED/97206480; Morakote N; Siriprasert P; Piangjai S; Vitayasai P; Tookyang B; Uparanukraw P; Department of Parasitology, Faculty of Medicine, Chiang Mai; University, Thailand.
A risk index for sexually transmitted diseases.: Sex Transm Dis. 1997 Feb;24(2):102-8. Unique Identifier : AIDSLINE MED/97265897; Stigum H; Magnus P; Department of Epidemiology, National Institute of Public Health, Oslo,; Norway.; BACKGROUND AND OBJECTIVES: The basic reproductive ratio, RO, is a useful measure to compare the potential for spread of sexually transmitted diseases (STDs) between populations. But RO is a population risk measure; and individual risk index is needed. STUDY DESIGN: An individual, STD-specific potential risk index was
The natural history of human immunodeficiency virus infection among women as compared with men.: Sex Transm Dis. 1997 Feb;24(2):77-83. Unique Identifier : AIDSLINE MED/97265893; Suligoi B; Laboratory of Epidemiology and Biostatistics, Istituto Superiore di; Sanita, Rome, Italy.; There has been growing interest in the issue of human immunodeficiency virus infection among women, both because of the increasing number of women worldwide infected in recent years and consequently a higher number of infected children) and because of the higher efficacy of male-to-female transmission of human immunod
Apparent failure of one injection of benzathine penicillin G for syphilis during pregnancy in human immunodeficiency virus-seronegative African women.: Sex Transm Dis. 1997 Feb;24(2):94-101. Unique Identifier : AIDSLINE MED/97265896; Donders GG; Desmyter J; Hooft P; Dewet GH; Department of Obstetrics and Gynecology, Katholieke Universiteit; Leuven, Belgium.; BACKGROUND: Syphilis remains a major cause of premature birth, fetal and perinatal death, and congenital syphilis in South Africa , despite systematic antenatal screening by rapid plasma reagin and treatment with 2.4 million U of benzathine penicillin G. GOAL: To determine whether
Photochemical inactivation of viruses and bacteria in platelet concentrates by use of a novel psoralen and long-wavelength ultraviolet light.: Transfusion. 1997 Apr;37(4):423-35. Unique Identifier : AIDSLINE MED/97265344; Lin L; Cook DN; Wiesehahn GP; Alfonso R; Behrman B; Cimino GD; Corten L; Damonte PB; Dikeman R; Dupuis K; Fang YM; Hanson CV; Hearst JE; Lin CY; Londe HF; Metchette K; Nerio AT; Pu JT; Reames AA; Rheinschmidt M; Tessman J; Isaacs ST; Wollowitz S; Corash L; Cerus Corporation (formerly Steritech, Inc.), Concord, California; 94520, USA.; BACKGROUND: A photochemical treatment process has been developed for the inactivation of viruses and bacteria in platelet concentrates. This process is based on the photochemical reaction of a novel psoralen, S-59, with nucleic acids upon illumination with long-wavelength ultraviolet light (UVA, 320-400 nm). STUDY DES
Islet rejection in perforin-deficient mice: the role of perforin and Fas.: Transplantation. 1997 Apr 15;63(7):951-7. Unique Identifier : AIDSLINE MED/97266604; Ahmed KR; Guo TB; Gaal KK; Department of Medicine, Harbor-UCLA Medical Center, Torrance,; California 90509, USA.; BACKGROUND: Perforin and Fas are the two main pathways by which cytotoxic T lymphocytes (CTLs) mediate target cell lysis in vitro. The perforin pathway is predominantly used by CD8+ cells, which comprise the majority of CTLs. The Fas pathway has been demonstrated to be the principal cytolytic mechanism in CD4+ CTLs. C
[Mechanism of relationship between HIV infection and autoimmunity]: Vopr Med Khim. 1996 Jul-Sep;42(3):211-6. Unique Identifier : AIDSLINE MED/97221042; Smirnova IP; Alekseev SB; Berezov TT; The mechanism of autoimmunity suppression of T-lymphocytes with 18K-antigen as marker of autoimmunopathology developments was investigated. Mushroom,s L-lysine alpha-oxidase was used as immunomodulator. It was suggested that the development, of the first stage autoimmunity pathology may be realized via overproductive
Eliciting HIV-1 envelope-specific antibodies with mixed vaccinia virus recombinants.: Vaccine. 1997 Feb;15(3):265-72. Unique Identifier : AIDSLINE MED/97227578; Rencher SD; Lockey TD; Srinivas RV; Owens RJ; Hurwitz JL; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38101, USA.; Recombinant vaccinia virus (VV) vectors that express the envelope Env) protein of the human immunodeficiency virus-type 1 (HIV-1) have been previously shown to elicit HIV-specific cytotoxic T-lymphocyte (CTL) and weak antibody responses in non-human primate studies and clinical trials. In first clinical trials, single
Role of cytology in the intraoperative diagnosis of HIV-positive patients undergoing stereotactic brain biopsy.: Acta Cytol. 1997 Mar-Apr;41(2):481-6. Unique Identifier : AIDSLINE MED/97255437; Cajulis RS; Hayden R; Frias-Hidvegi D; Brody BA; Yu GH; Levy R; Department of Pathology, Northwestern University, Chicago, Illinois,; USA.; OBJECTIVE: To determine the accuracy of cytology in the intraoperative diagnosis of central nervous system (CNS) lesions in human immunodeficiency (HIV)-positive patients. STUDY DESIGN: We prospectively studied 75 cases of computed tomography- or magnetic resonance imaging-guided brain biopsies performed with stereota
Cytologic diagnosis of Cryptococcus neoformans in HIV-positive patients.: Acta Cytol. 1997 Mar-Apr;41(2):493-6. Unique Identifier : AIDSLINE MED/97255439; Kanjanavirojkul N; Sripa C; Puapairoj A; Department of Pathology, Faculty of Medicine, Khon Kaen University,; Thailand.; OBJECTIVE: To present experience with the cytologic diagnosis of pulmonary cryptococcosis in bronchial washings and bronchoalveolar lavage in human immunodeficiency virus HIV)-positive patients in Thailand . STUDY DESIGN: The study group consisted of 54 HIV-positive patients admit
Pulmonary malacoplakia associated with Rhodococcus equi infection in an AIDS patient. Report of a case with diagnosis by fine needle aspiration.: Acta Cytol. 1997 Mar-Apr;41(2):507-12. Unique Identifier : AIDSLINE MED/97255442; Sughayer M; Ali SZ; Erozan YS; Dunsmore N; Hall GS; John K. Frost Cytopathology Laboratory, Department of Pathology, Johns; Hopkins Hospital, Baltimore, Maryland, USA.; BACKGROUND: Malacoplakia is an uncommon, peculiar inflammatory disease with few cytologic descriptions. It is seen mostly in the lower urinary tract, with rare occurrences in the lungs. Escherichia coli is the most common underlying etiologic agent, with only a few cases reported with Rhodococcus equi infection. CASE:
Pulmonary sporotrichosis with hyphae in a human immunodeficiency virus-infected patient. A case report.: Acta Cytol. 1997 Mar-Apr;41(2):519-21. Unique Identifier : AIDSLINE MED/97255444; Gori S; Lupetti A; Moscato G; Parenti M; Lofaro A; Department of Microbiology, Hospital of Pisa, Italy.; BACKGROUND: Pulmonary sporotrichosis is a rare event. Sporothrix schenckii is a dimorphic fungus and develops at 37 degrees C in yeast form. Usually hyphae are not observed in tissues, although their presence has been occasionally demonstrated in biopsies. CASE: A 37-year-old man, human immunodeficiency virus-1 positi
Patterns and predictors of cocaine and crack use by clients in standard and enhanced methadone maintenance treatment.: Am J Drug Alcohol Abuse. 1997 Feb;23(1):15-42. Unique Identifier : AIDSLINE MED/97200210; Grella CE; Anglin MD; Wugalter SE; UCLA Drug Abuse Research Center 90024, USA.; This paper reports on the patterns of cocaine use among subjects N = 427) admitted to a methadone maintenance treatment demonstration project designed to reduce risk for HIV. Assessments were conducted at intake and at approximately 18-24 months after treatment admission. Self-reported data on cocaine use was compared
Background to crack cocaine addiction and HIV high-risk behavior: the next epidemic.: Am J Drug Alcohol Abuse. 1997 Feb;23(1):67-77. Unique Identifier : AIDSLINE MED/97200213; Word CO; Bowser B; California Institute of Integral Studies, San Francisco 94109, USA.; BACKGROUND: Increasing rates of sexually transmitted diseases among users of noninjection drugs prompt speculation that crack cocaine users who do not inject are at particularly high risk of HIV (human immunodeficiency virus) infection. METHODS: A street recruitment technique was employed to enroll 331 primarily Afric
Progression to acquired immunodeficiency syndrome is influenced by CD4 T-lymphocyte count and time since seroconversion.: Am J Epidemiol. 1997 Apr 1;145(7):629-35. Unique Identifier : AIDSLINE MED/97252722; Begtrup K; Melbye M; Biggar RJ; Goedert JJ; Knudsen K; Andersen PK; Danish Epidemiology Science Centre, Statens Seruminstitut, Copenhagen,; Denmark.; Progression to acquired immunodeficiency syndrome (AIDS) among persons infected with human immunodeficiency virus (HIV) varies considerably and may be influenced by factors such as age, smoking, number of male partners per year, and CD4 T-lymphocyte count. The loss of CD4 lymphocytes is known to be the dominant factor
Effect of changing partnership formation rates on the spread of sexually transmitted diseases and human immunodeficiency virus.: Am J Epidemiol. 1997 Apr 1;145(7):644-52. Unique Identifier : AIDSLINE MED/97252724; Stigum H; Magnus P; Bakketeig LS; Department of Epidemiology, National Institute of Public Health, Oslo,; Norway.; Core population groups play an important role in the spread of sexually transmitted diseases. Subjects in a core group may change their behavior over time and migrate to the noncore. The authors examined the effects of such migration on the prevalence of gonorrhea, chlamydia, and human immunodeficiency virus (HIV) u
Hospital controls versus community controls: differences in inferences regarding risk factors for hip fracture.: Am J Epidemiol. 1997 Apr 1;145(7):653-60. Unique Identifier : AIDSLINE MED/97252725; Moritz DJ; Kelsey JL; Grisso JA; Department of Epidemiology and Biostatistics, School of Medicine,; University of California, San Francisco, USA.; In case-control studies using cases identified from persons admitted to hospitals, two types of controls are most often used: persons from the communities served by the hospitals and persons admitted to the same hospitals as those to which the cases were admitted. It is often unclear which is the more appropriate choi
Risk of Kaposi's sarcoma and oroanal sexual contact.: Am J Epidemiol. 1997 Apr 15;145(8):673-9. Unique Identifier : AIDSLINE MED/97271042; Grulich AE; Kaldor JM; Hendry O; Luo K; Bodsworth NJ; Cooper DA; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, Darlinghurst, Australia.; After contradictory findings from a number of previous studies, behavioral risk factors for Kaposi s sarcoma were examined in a case-control study of 202 people diagnosed with acquired immunodeficiency syndrome (AIDS) in 1991-1993 in Sydney, Australia . Cases comprised 67 men who
HIV-positive and AIDS-infected women: challenges and difficulties of mothering.: Am J Orthopsychiatry. 1997 Jan;67(1):144-51. Unique Identifier : AIDSLINE MED/97186455; Faithfull J; Department of Psychiatry, Cambridge Hospital, Mass., USA.; The impact of HIV/AIDS on the ability of 12 mothers to raise their children was explored. Three key themes emerged: disclosure, fear of infecting children through casual contact, and impact of grief. The implications of these findings for research and provision of services are discussed.
Distress and coping among women with HIV infection: preliminary findings from a multiethnic sample.: Am J Orthopsychiatry. 1997 Jan;67(1):80-91. Unique Identifier : AIDSLINE MED/97186449; Kaplan MS; Marks G; Mertens SB; School of Social Work, University of Illinois at Urbana-Champaign,; USA.; In a multiethnic sample of 53 women with HIV/AIDS, nearly 40% reported clinically significant levels of depression symptomatology and anxiety. Compared to a nonpatient norm, distress levels were higher among the Latina, African-American, and white women who made up the HIV sample. Prayer and rediscovery of self were t
Psychotherapy with HIV-positive gay men: a psychodynamic perspective.: Am J Psychother. 1997 Winter;51(1):31-44. Unique Identifier : AIDSLINE MED/97205665; Weiss JJ; Helen Dowling Institute for Biopsychosocial Medicine, Rotterdam,; Netherlands.; This paper examines psychotherapy with HIV-positive gay men from a psychodynamic perspective. Adjustment to being HIV-positive is conceptualized as an ongoing process of confrontation with loss and uncertainty. Interventions offered to HIV-positive gay men range from counseling, indicated in response to an uncomplicat
Cryptosporidium infections in Mexican children: clinical, nutritional, enteropathogenic, and diagnostic evaluations.: Am J Trop Med Hyg. 1997 Mar;56(3):254-7. Unique Identifier : AIDSLINE MED/97275756; Javier Enriquez F; Avila CR; Ignacio Santos J; Tanaka-Kido J; Vallejo O; Sterling CR; Department of Veterinary Science, University of Arizona, Tucson, USA.; Using an indirect immunofluorescence assay on stool samples, we found a 6.4% prevalence of cryptosporidiosis among 403 children less than five years of age with acute diarrhea in Mexico City over a one-year period. The prevalence was highest (11.4%) during the rainy summer months. Most Cryptosporidium parvum cases occ
Hepatitis B virus, human immunodeficiency virus type-1, and syphilis among women attending prenatal clinics in Belize, Central America.: Am J Trop Med Hyg. 1997 Mar;56(3):285-90. Unique Identifier : AIDSLINE MED/97275760; Scott-Wright A; Hakre S; Bryan JP; Jaramillo R; Reyes LG; Cruess D; Macarthy PO; Gaydos JC; Department of Preventive Medicine and Biometrics, Uniformed Services; University of the Health Sciences, Bethesda, Maryland, USA.; Women and their infants may benefit from therapeutic interventions when hepatitis B, human immunodeficiency virus HIV), or syphilis are detected during the prenatal period. We initiated hepatitis B and HIV screening of women attending prenatal clinics in Belize . Risk factor assessm
Reverse transcriptase-polymerase chain reaction amplification and partial sequence of T helper 1- and T helper 2-type lymphokine genes from the owl monkey (Aotus trivirgatus).: Am J Trop Med Hyg. 1997 Mar;56(3):351-8. Unique Identifier : AIDSLINE MED/97275772; Bost KL; Hellner CF Jr; Holton RH; Ratterree MS; Clements JD; Krogstad DJ; Kincy-Cain T; Department of Microbiology, Tulane University Medical Center New; Orleans, Louisiana, USA.; The reverse transcriptase-polymerase chain reaction (RT-PCR) was used to amplify selected lymphokine mRNAs from phytohemagglutinin-activated leukocytes of the owl monkey (Aotus trivirgatus). Interleukin-2 ( IL-2 ), IL-4, IL-13, and interferon-gamma were selected as lymph
HIV and bloodborne infections in emergency medicine. American College of Emergency Physicians.: Ann Emerg Med. 1997 Apr;29(4):571-2. Unique Identifier : AIDSLINE MED/97249124
Weekly fluconazole for the prevention of mucosal candidiasis in women with HIV infection. A randomized, double-blind, placebo-controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS.: Ann Intern Med. 1997 May 1;126(9):689-96. Unique Identifier : AIDSLINE MED/97267478; Schuman P; Capps L; Peng G; Vazquez J; el-Sadr W; Goldman AI; Alston B; Besch CL; Vaughn A; Thompson MA; Cobb MN; Kerkering T; Sobel JD; BACKGROUND: Candidiasis is a frequent complication of infection with the human immunodeficiency virus (HIV); however, few data exist about the natural history, prevention, and treatment of mucosal candidiasis in women. OBJECTIVE: To evaluate the safety and effectiveness of weekly fluconazole prophylaxis for mucosal ca
Polymerase chain reaction for diagnosis of HIV infection [letter; comment]: Ann Intern Med. 1997 May 1;126(9):739-40. Unique Identifier : AIDSLINE MED/97267489; Brown AE; Robb M; McCutchan F
Telling the truth to cancer patients and patients with HIV-1 infection in Japan.: Ann N Y Acad Sci. 1997 Feb 20;809:279-89. Unique Identifier : AIDSLINE MED/97256875; Mitsuya H; Experimental Retrovirology Section, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.: Antimicrob Agents Chemother. 1997 Feb;41(2):262-8. Unique Identifier : AIDSLINE MED/97173271; Witvrouw M; Balzarini J; Pannecouque C; Jhaumeer-Laulloo S; Este JA; Schols D; Cherepanov P; Schmit JC; Debyser Z; Vandamme AM; Desmyter J; Ramadas SR; de Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; From a series of macrocyclic diamides possessing the disulfide linkage, only SRR-SB3, a compound that complexes with zinc, was found to inhibit human immunodeficiency virus type 1 (HIV-1; strain IIIB) replication at a concentration of 1.8 to 6.5 micrograms/ml in MT-4, CEM, and peripheral blood mononuclear cells. SRR-S
A zidovudine-resistant simian immunodeficiency virus mutant with a Q151M mutation in reverse transcriptase causes AIDS in newborn macaques.: Antimicrob Agents Chemother. 1997 Feb;41(2):278-83. Unique Identifier : AIDSLINE MED/97173274; Van Rompay KK; Greenier JL; Marthas ML; Otsyula MG; Tarara RP; Miller CJ; Pedersen NC; California Regional Primate Research Center, University of California,; Davis 95616, USA.; The simian immunodeficiency virus (SIV)-newborn rhesus macaque model of AIDS can be used to study directly the virulence of viral mutants which are resistant to antiviral drugs. A viral mutant called SIVmac79A6.1, isolated from an SIV-infected macaque after prolonged zidovudine treatment, was found to have a double-ba
Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene.: Antimicrob Agents Chemother. 1997 Feb;41(2):284-91. Unique Identifier : AIDSLINE MED/97173275; Stuyver L; Wyseur A; Rombout A; Louwagie J; Scarcez T; Verhofstede C; Rimland D; Schinazi RF; Rossau R; Innogenetics N.V., Ghent, Belgium. lievestu@innogenetics.be; Upon prolonged treatment with various antiretroviral nucleoside analogs such as 3 -azido-3 -deoxythymidine, 2 ,3 -dideoxyinosine, 2 ,3 -dideoxycytidine, (-)- beta-L-2 , 3 dideoxy-3 thiacytidine and 2 ,3 -didehydro-3 -deoxythymidine, selection of human immunodeficiency virus type 1 (HIV-1) strains with mutations in the
Decoy approach using RNA-DNA chimera oligonucleotides to inhibit the regulatory function of human immunodeficiency virus type 1 Rev protein.: Antimicrob Agents Chemother. 1997 Feb;41(2):319-25. Unique Identifier : AIDSLINE MED/97173280; Nakaya T; Iwai S; Fujinaga K; Sato Y; Otsuka E; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; Human immunodeficiency virus type 1 (HIV-1) encodes two regulatory proteins, Tat and Rev, that bind to target RNA sequences. These are the trans-activation responsive (TAR) RNA and the Rev-responsive element (RRE), respectively. The Rev protein shifts RNA synthesis to viral transcripts by binding to the RRE within the
Pneumocandin L-743,872 enhances the activities of amphotericin B and fluconazole against Cryptococcus neoformans in vitro.: Antimicrob Agents Chemother. 1997 Feb;41(2):331-6. Unique Identifier : AIDSLINE MED/97173282; Franzot SP; Casadevall A; Department of Medicine, Albert Einstein College of Medicine, Bronx,; New York 10461, USA.; Cryptococcus neoformans infections in patients with AIDS are often incurable, despite aggressive antifungal therapy. Combination regimens with additive or synergistic drugs could provide additional options for treating cryptococcal meningitis. We evaluated the efficacy of combination therapies using L-743,872, a pneum
Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.: Antimicrob Agents Chemother. 1997 Feb;41(2):385-93. Unique Identifier : AIDSLINE MED/97173290; Neamati N; Mazumder A; Zhao H; Sunder S; Burke TR Jr; Schultz RJ; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Institute,; Bethesda, Maryland 20892, USA.; A majority of reported human immunodeficiency virus type 1 integrase (HIV-1 IN) inhibitors are polyhydroxylated aromatic compounds containing two phenyl rings separated by aliphatic or aromatic linkers. Most inhibitors possessing a catechol moiety exhibit considerable toxicity in cellular assays. In an effort to ident
The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities.: Antimicrob Agents Chemother. 1997 Feb;41(2):394-400. Unique Identifier : AIDSLINE MED/97173291; Tummino PJ; Harvey PJ; McQuade T; Domagala J; Gogliotti R; Sanchez J; Song Y; Hupe D; Department of Biochemistry, Parke-Davis Pharmaceutical Research, Ann; Arbor, Michigan 48105, USA.; It has been shown previously by our group and others that a series of four disulfide benzamides with cellular anti-human immunodeficiency virus (HIV) activity can eject zinc from HIV type 1 nucleocapsid protein (NCp7) in vitro while analogs without antiviral activity do not. We also found that the zinc ejection activi
Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum.: Antimicrob Agents Chemother. 1997 Feb;41(2):410-4. Unique Identifier : AIDSLINE MED/97173293; Wheat J; Marichal P; Vanden Bossche H; Le Monte A; Connolly P; Department of Medicine and Pathology, Indiana University School of; Medicine, Indianapolis, USA. joe@idwish.dmed.iupui.edu; An AIDS patient with disseminated histoplasmosis who improved during treatment with fluconazole but remained fungemic and subsequently relapsed is described. Isolates obtained from blood during therapy showed a progressive increase in fluconazole MIC from 0.625 to 20 micrograms/ml. The pretreatment, or parent, isolate
Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.: Antimicrob Agents Chemother. 1997 Feb;41(2):419-26. Unique Identifier : AIDSLINE MED/97173295; Rice WG; Baker DC; Schaeffer CA; Graham L; Bu M; Terpening S; Clanton D; Schultz R; Bader JP; Buckheit RW Jr; Field L; Singh PK; Turpin JA; Laboratory of Antiviral Drug Mechanisms, National Cancer; Institute-Frederick Cancer Research and Development Center, Frederick,; Maryland 21702-1201, USA. rice@dtpax2.ncifcrf.gov; The human immunodeficiency virus type 1 (HIV-1) nucleocapsid p7 protein contains two retrovirus-type zinc finger domains that are required for multiple phases of viral replication. Chelating residues (three Cys residues and one His residue) of the domains are absolutely conserved among all strains of HIV-1 and other r
Modeling of the change in CD4 lymphocyte counts in patients before and after administration of the human immunodeficiency virus protease inhibitor indinavir.: Antimicrob Agents Chemother. 1997 Feb;41(2):449-53. Unique Identifier : AIDSLINE MED/97173300; Stein DS; Drusano GL; Department of Medicine, Albany Medical College, New York 12208, USA.; We investigated the relationships between changes in CD4 lymphocytes counts over 24 weeks after the initiation of therapy with indinavir at dosages of > or = 2.4 g/day (n = 15) in human immunodeficiency virus-positive patients and compared them to the
Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea.: Antimicrob Agents Chemother. 1997 Feb;41(2):460-4. Unique Identifier : AIDSLINE MED/97173302; Palmer S; Cox S; Virology Department, Swedish Institute for Infectious Disease Control,; Karolinska Institute, Stockholm, Sweden.; The intracellular phosphorylation of 3 -azido-3 -deoxythymidine and 2 -deoxy-3 -thiacytidine was increased two- to threefold by the addition of hydroxyurea (HU) to the single drugs or to the two drugs in combination. The ratios of drug triphosphate to competing cellular deoxynucleoside triphosphate were increased two-
New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase.: Antiviral Res. 1996 May;30(2-3):109-24. Unique Identifier : AIDSLINE MED/96378028; Bellarosa D; Antonelli G; Bambacioni F; Giannotti D; Viti G; Nannicini R; Giachetti A; Dianzani F; Witvrouw M; Pauwels R; Desmyter J; De Clercq E; Institute of Virology, University La Sapienza, Rome, Italy.; A series of pyridobenzothiodiazepindioxides such as the 11-ethyl-6,8,9-trimethyl-6,11-dihydro-pyrido[2,3-f] [2,1,5]benzothiodiazepine-5,5-dioxide and arylpiridodiazepines such as the 6,7-dihydro-7-methyl-12-ethyl-pyrido[2,3-b] pyrido(2 ,3 -4,5]furo[2,3-f][1,4]diazepin-6(12H)-thio and the 6,7-dihydro-7-methyl-12-ethyl-
DNA polymerase activity of hepatitis B virus particles: differential inhibition by L-enantiomers of nucleotide analogs.: Antiviral Res. 1996 May;30(2-3):133-45. Unique Identifier : AIDSLINE MED/96378030; Davis MG; Wilson JE; VanDraanen NA; Miller WH; Freeman GA; Daluge SM; Boyd FL; Aulabaugh AE; Painter GR; Boone LR; Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA.; DNA polymerase activity was assayed in hepatitis B virus (HBV) and core particles isolated from chronic producer lines. The particle-associated DNA polymerase activity, which was found to be limited to incorporation of only a few nucleotides, was inhibited by the 5 -triphosphates of nucleoside analogs. The 1-beta-L (1
The inhibition of human immunodeficiency virus proteases by interface peptides'.: Antiviral Res. 1996 May;30(2-3):155-70. Unique Identifier : AIDSLINE MED/96378032; Schramm HJ; Boetzel J; Buttner J; Fritsche E; Gohring W; Jaeger E; Konig S; Thumfart O; Wenger T; Nagel NE; Schramm W; Max-Planck-Institut fur Biochemie, Martinsried, Germany.; The active human immunodeficiency virus type 1 (HIV-1) protease has a homodimeric structure, the subunits are connected by an interface beta-sheet formed by the NH2- and COOH-terminal amino acid segments. Short peptides derived from these segments are able to inhibit the protease activity in the range of micromolar I
Antiviral properties of extract of Opuntia streptacantha.: Antiviral Res. 1996 May;30(2-3):75-85. Unique Identifier : AIDSLINE MED/96378025; Ahmad A; Davies J; Randall S; Skinner GR; Department of Infection, Medical School, University of Birmingham, UK.; An extract of the cactus plant Opuntia streptacantha inhibited intracellular virus replication and inactivated extracellular virus. Inhibition of virus replication also occurred following pre-infection treatment--a favourable finding in terms of in-vivo limitation of virus disease. There was inhibition of both DNA and
Sulfated pentagalloyl glucose (Y-ART-3) inhibits HIV replication and cytopathic effects in vitro, and reduces HIV infection in hu-PBL-SCID mice.: Antiviral Res. 1996 May;30(2-3):95-108. Unique Identifier : AIDSLINE MED/96378027; Nakashima H; Ichiyama K; Hirayama F; Uchino K; Ito M; Saitoh T; Ueki M; Yamamoto N; Ogawara H; Department of Microbiology, Yamanashi Medical University, Japan.; To evaluate the efficacy of Y-ART-3 as an antiviral drug for HIV infections, its anti-HIV activity was assessed in vitro in cell culture systems and in vivo in hu-PBL-SCID mice. The results indicated that Y-ART-3 invariably inhibited not only HIV-1, but also HIV-2 and SIV strains. Its mechanism of action is ascribed t
Cellular factors as alternative targets for inhibition of HIV-1.: Antiviral Res. 1997 Feb;33(3):141-52. Unique Identifier : AIDSLINE MED/97189100; Baba M; Division of Human Retroviruses, Faculty of Medicine, Kagoshima; University, Japan.
Red blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency metabolism and activity against human immunodeficiency virus or herpes simplex virus.: Antiviral Res. 1997 Feb;33(3):153-64. Unique Identifier : AIDSLINE MED/97189101; Perno CF; Santoro N; Balestra E; Aquaro S; Cenci A; Lazzarino G; Di Pierro D; Tavazzi B; Balzarini J; Garaci E; Grimaldi S; Calio R; Department of Experimental Medicine and Biochemical Sciences,; University of Rome Tor Vergata, Italy.; Red blood cells (RBC) may act as selective carriers of drugs to macrophages, an important reservoir of viruses such as human immunodeficiency virus (HIV) and herpes simplex virus type 1 HSV-1). We therefore assessed the incorporation of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent inhibitor of HIV and HSV-1) i
[Morpho-immunologic phenotypes of T-cell non-Hodgkin's malignant lymphoma in baboons and their connection with with T-lymphotropic retrovirus STLV-1]: Arkh Patol. 1997 Jan-Feb;59(1):19-25. Unique Identifier : AIDSLINE MED/97228744; Iakovleva LA; Indzhiia LV; Chikobaeva MG; Shatsl' G; Lapin BA; Max von Pettenkofer Institute, Munchen, Germany.; 8 cytological types were detected among 58 cases of T-NHL of Papio hamadryas according to human updated Kiel classification 1988). 5 of them were of low grade (lymphocytic, prolymphocytic, T-zone, angioimmunoblastic, small cell pleomorphic) and 3-of high grade (medium and large cell pleomorphic, immunoblastic, large c
Hearing loss and antiretroviral therapy in patients infected with HIV-1.: Arch Neurol. 1997 Apr;54(4):407-10. Unique Identifier : AIDSLINE MED/97263870; Marra CM; Wechkin HA; Longstreth WT Jr; Rees TS; Syapin CL; Gates GA; Department of Neurology, University of Washington, Seattle, USA.; OBJECTIVE: To explore the association between hearing loss and antiretroviral therapy in human immunodeficiency virus type 1 HIV-1)-infected persons. DESIGN: Case-control study. SETTING: University-based HIV clinic. PARTICIPANTS: Volunteer sample of 99 HIV-infected patients. INTERVENTIONS: Standardized interview focus
Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group.: Arch Neurol. 1997 Apr;54(4):416-24. Unique Identifier : AIDSLINE MED/97263871; Ellis RJ; Deutsch R; Heaton RK; Marcotte TD; McCutchan JA; Nelson JA; Abramson I; Thal LJ; Atkinson JH; Wallace MR; Grant I; Department of Neurosciences, University of California, Department of; Medicine, San Diego, USA. roellis@ucsd.edu; OBJECTIVE: To determine if mortality is increased in individuals with human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorders less severe than frank dementia . DESIGN: A prospective cohort study; median duration of follow-up was 2.4 years. Kaplan-Meier analys
Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection.: Biochem Pharmacol. 1997 Mar 21;53(6):755-63. Unique Identifier : AIDSLINE MED/97267767; Baier-Bitterlich G; Fuchs D; Wachter H; Institute for Medical Chemistry and Biochemistry University of; Innsbruck, Austria.; Infection with the human immunodeficiency virus (HIV) is accompanied by a decrease in CD4+ T cell numbers and the ultimate disruption of immunological functions. In sera of infected patients, elevated levels of interferon-gamma are detected, which is indicative of an activated TH1-type immune response. T-cell-derived
Screening and treatment of sexually transmitted diseases: an important strategy for reducing the risk of HIV transmission.: Aids Patient Care STDS. 1996 Feb;10(1):10-5. Unique Identifier : AIDSLINE MED/97229438; Hitchcock PJ; Sexually Transmitted Diseases Branch, National Institute of Allergy; and Infectious Diseases, Bethesda, MD 20892, USA.; The role of sexually transmitted diseases (STDs) in the spread of human immunodeficiency virus (HIV) infection is reviewed. The rationale for and approach to reducing STD prevalence in high-risk communities are presented. Given the asymptomatic nature of these infections and problems associated with delivering curativ
Small airways dysfunction in patients with AIDS and Pneumocystis carinii pneumonia.: Aids Patient Care STDS. 1996 Feb;10(1):16-20. Unique Identifier : AIDSLINE MED/97229439; Fleischman JK; Greenberg H; Web A; Queens Hospital Center, Mount Sinai School of Medicine, New York, NY,; USA.; PURPOSE: Abnormalities of small airways function may have clinical relevance in AIDS patients with Pneumocystis carinii pneumonia (PCP) since obstructive dysfunction at alveolar levels may impede delivery of aerosolized medication. This study was designed to determine if small airways dysfunction is present in AIDS pa
The HIV/AIDS pandemic and the evolving role of primary care [editorial]: Aids Patient Care STDS. 1996 Feb;10(1):2-4. Unique Identifier : AIDSLINE MED/97229435; Laurence J
Delayed entry into health care for women with HIV disease.: Aids Patient Care STDS. 1996 Feb;10(1):21-4. Unique Identifier : AIDSLINE MED/97229440; Ickovics JR; Forsyth B; Ethier KA; Harris P; Rodin J; Department of Internal Medicine, Yale University School of Medicine,; New Haven, CT, USA.; OBJECTIVE: The primary objective was to evaluate factors that might influence delayed entry into health care for women with HIV. Implications of time of diagnosis for early medical intervention was a focused aspect. PROCEDURE: Structured clinical interviews were conducted with HIV-positive women (n = 48); these data w
Diarrhea in HIV-infected individuals: a review.: Aids Patient Care STDS. 1996 Feb;10(1):25-31. Unique Identifier : AIDSLINE MED/97229441; Bowers JM; Dols CL; Barreuther CJ; VA Medical Center, Tucson, AZ, USA.
Complementary therapy use among HIV-infected patients.: Aids Patient Care STDS. 1996 Feb;10(1):32-6. Unique Identifier : AIDSLINE MED/97229442; Bates BR; Kissinger P; Bessinger RE; School of Public Health and Tropical Medicine, Tulane University, New; Orleans, LA, USA.; This study investigates factors associated with the self-reported use of complementary therapies, types of therapies used, and sources of complementary therapy information among HIV-positive patients attending a public, HIV outpatient clinic in New Orleans. A convenience sample of 287 clients (220 men and 67 women) wa
Reducing barriers to care and improving quality of life for rural persons with HIV.: Aids Patient Care STDS. 1996 Feb;10(1):37-43. Unique Identifier : AIDSLINE MED/97229443; Heckman TG; Somlai AM; Kelly JA; Stevenson LY; Galdabini K; Center for AIDS Intervention Research (CAIR), Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, USA.; Rural persons living with HIV disease is a patient group rapidly increasing in size and one that will present America s health-care system with daunting challenges. As the HIV epidemic increasingly affects rural America, it is clear there are many significant barriers to providing adequate care for persons with HIV an
Coping behaviors of mothers with HIV/AIDS.: Aids Patient Care STDS. 1996 Feb;10(1):44-7. Unique Identifier : AIDSLINE MED/97229444; Rose MA; Clark-Alexander B; Medical College of Pennsylvania/Hahneman University School of Nursing; in Philadelphia, USA.
Research study of combination AIDS therapies underway [news]: Aids Patient Care STDS. 1996 Feb;10(1):48. Unique Identifier : AIDSLINE MED/97229446
3TC approved [news]: Aids Patient Care STDS. 1996 Feb;10(1):48. Unique Identifier : AIDSLINE MED/97229445
Anti-HIV-1 agent AR-177 blocks HIV integrase [news]: Aids Patient Care STDS. 1996 Feb;10(1):48-9. Unique Identifier : AIDSLINE MED/97229447
Drug completely protects monkeys exposed to SIV [news]: Aids Patient Care STDS. 1996 Feb;10(1):49-50. Unique Identifier : AIDSLINE MED/97229448
Elevations of follicle-stimulating hormone (FSH) and leutinizing hormone (LH) with normal, or near normal, serum free testosterone levels [letter]: Aids Patient Care STDS. 1996 Feb;10(1):5. Unique Identifier : AIDSLINE MED/97229436; Harris PJ
Crixivan reduces viral load [news]: Aids Patient Care STDS. 1996 Feb;10(1):50. Unique Identifier : AIDSLINE MED/97229450
Protease inhibitor combination [news]: Aids Patient Care STDS. 1996 Feb;10(1):50. Unique Identifier : AIDSLINE MED/97229449
Testosterone study seeks participants [news]: Aids Patient Care STDS. 1996 Feb;10(1):51. Unique Identifier : AIDSLINE MED/97229452
Thalidomide effective in treating AIDS-related mouth ulcers [news]: Aids Patient Care STDS. 1996 Feb;10(1):51. Unique Identifier : AIDSLINE MED/97229451
Itraconazole now indicated to treat fungal nail disease [news]: Aids Patient Care STDS. 1996 Feb;10(1):51-2. Unique Identifier : AIDSLINE MED/97229453
Analyses of peptide T efficacy on neuropsychological performance [news]: Aids Patient Care STDS. 1996 Feb;10(1):52. Unique Identifier : AIDSLINE MED/97229454
Volunteers needed for study of HIV viral load test [news]: Aids Patient Care STDS. 1996 Feb;10(1):52-3. Unique Identifier : AIDSLINE MED/97229455
Chancroid and TMP-SMX [news]: Aids Patient Care STDS. 1996 Feb;10(1):53. Unique Identifier : AIDSLINE MED/97229457
Redesign of vaccine trials suggested [news]: Aids Patient Care STDS. 1996 Feb;10(1):53. Unique Identifier : AIDSLINE MED/97229456
Antifungals and resistance [news]: Aids Patient Care STDS. 1996 Feb;10(1):54. Unique Identifier : AIDSLINE MED/97229459
Clarithromycin and MAC [news]: Aids Patient Care STDS. 1996 Feb;10(1):54. Unique Identifier : AIDSLINE MED/97229458
Genomic vaccines being developed [news]: Aids Patient Care STDS. 1996 Feb;10(1):54. Unique Identifier : AIDSLINE MED/97229460
AmFAR Awards $977,457 in new research grants [news]: Aids Patient Care STDS. 1996 Feb;10(1):55. Unique Identifier : AIDSLINE MED/97229461
Glaser Awards given [news]: Aids Patient Care STDS. 1996 Feb;10(1):55-6. Unique Identifier : AIDSLINE MED/97229462
AIDS/HIV information database logs 120,000 requests in first months on Internet [news]: Aids Patient Care STDS. 1996 Feb;10(1):56-7. Unique Identifier : AIDSLINE MED/97229463
ACRC awarded capital challenge grant from AmFAR [news]: Aids Patient Care STDS. 1996 Feb;10(1):57. Unique Identifier : AIDSLINE MED/97229465
AIDS and Substance Abuse Speakers Network [news]: Aids Patient Care STDS. 1996 Feb;10(1):57. Unique Identifier : AIDSLINE MED/97229464
AHA closes its infection control program [news]: Aids Patient Care STDS. 1996 Feb;10(1):58. Unique Identifier : AIDSLINE MED/97229466
NFID names CDC's Martone as executive director [news]: Aids Patient Care STDS. 1996 Feb;10(1):58. Unique Identifier : AIDSLINE MED/97229467
Guidelines updated for prevention of intravascular device-related infections [news]: Aids Patient Care STDS. 1996 Feb;10(1):59. Unique Identifier : AIDSLINE MED/97229468
AIDS and electronic communications news.: Aids Patient Care STDS. 1996 Feb;10(1):60-1. Unique Identifier : AIDSLINE MED/97229469; Makulowich JS; john@trainer.com
AIDS as a clinically curable disease: the growing optimism.: Aids Patient Care STDS. 1996 Feb;10(1):7-9. Unique Identifier : AIDSLINE MED/97229437; Gallo RC; Institute of Human Virology, University of Maryland Biotechnology; Institute, University of Maryland at Baltimore, USA.
Medication therapy among intravenous drug users (IDUs) with HIV infection.: Aids Patient Care STDS. 1996 Apr;10(2):101-10. Unique Identifier : AIDSLINE MED/97229476; Smith PC; Page JB; Department of Psychiatry, University of Miami School of Medicine, FL,; USA.; With the identification of HIV-1 as the etiological agent of AIDS, infected people have pursued to varying degrees pharmaceutical treatment to arrest disease progress. This paper evaluates the use of AZT and other antiretroviral agents, as well as acc
HIV transmission knowledge and risk behaviors of persons with HIV infection.: Aids Patient Care STDS. 1996 Apr;10(2):111-5. Unique Identifier : AIDSLINE MED/97229477; Sowell RL; Seals BF; Cooper JA; College of Nursing, University of South Carolina, Columbia, USA.
Current management practices in the treatment of Pneumocystis carinii pneumonia (PCP).: Aids Patient Care STDS. 1996 Apr;10(2):116-21. Unique Identifier : AIDSLINE MED/97229478; Blanchet KD
Leading an AIDS support group: bringing it all together.: Aids Patient Care STDS. 1996 Apr;10(2):122-7. Unique Identifier : AIDSLINE MED/97229479; Schweska JJ; AIDS Clinical Services at Jersey City Medical Center, NJ, USA.
Public policy update: an AmFAR report.: Aids Patient Care STDS. 1996 Apr;10(2):128-9. Unique Identifier : AIDSLINE MED/97229480; Silver J
Famciclovir effective in suppressing recurrent genital herpes [news]: Aids Patient Care STDS. 1996 Apr;10(2):130. Unique Identifier : AIDSLINE MED/97229482
Pentafuside effective [news]: Aids Patient Care STDS. 1996 Apr;10(2):130. Unique Identifier : AIDSLINE MED/97229481
Combination trial with nevirapine underway [news]: Aids Patient Care STDS. 1996 Apr;10(2):130-1. Unique Identifier : AIDSLINE MED/97229483
Combination therapy dramatically reduces viral load [news]: Aids Patient Care STDS. 1996 Apr;10(2):131. Unique Identifier : AIDSLINE MED/97229485
Nevirapine expanded access program begins [news]: Aids Patient Care STDS. 1996 Apr;10(2):131. Unique Identifier : AIDSLINE MED/97229484
Research study of combination AIDS therapies underway [news]: Aids Patient Care STDS. 1996 Apr;10(2):132. Unique Identifier : AIDSLINE MED/97229487
Virend heals herpes lesions [news]: Aids Patient Care STDS. 1996 Apr;10(2):132. Unique Identifier : AIDSLINE MED/97229486
Anabolic steroid now available [news]: Aids Patient Care STDS. 1996 Apr;10(2):134. Unique Identifier : AIDSLINE MED/97229490
Azithromycin and OIs [news]: Aids Patient Care STDS. 1996 Apr;10(2):134. Unique Identifier : AIDSLINE MED/97229489
Pediatric vaccine trials limited in U.S. [news]: Aids Patient Care STDS. 1996 Apr;10(2):134. Unique Identifier : AIDSLINE MED/97229488
NIAID funds adult AIDS Clinical Trials Group [news]: Aids Patient Care STDS. 1996 Apr;10(2):134-5. Unique Identifier : AIDSLINE MED/97229491
Doxil receives FDA market clearance [news]: Aids Patient Care STDS. 1996 Apr;10(2):135. Unique Identifier : AIDSLINE MED/97229492
PDT therapy for KS shows promising results [news]: Aids Patient Care STDS. 1996 Apr;10(2):135. Unique Identifier : AIDSLINE MED/97229493
OSHA seeks comments from health care and other "high hazard" industries on best way to report injury and illness [news]: Aids Patient Care STDS. 1996 Apr;10(2):136-7. Unique Identifier : AIDSLINE MED/97229494
Tracking emerging infections via the Internet [news]: Aids Patient Care STDS. 1996 Apr;10(2):137. Unique Identifier : AIDSLINE MED/97229496
Voluntary HIV screening at high-prevalence hospitals may be as cost-effective as hypertension screening [news]: Aids Patient Care STDS. 1996 Apr;10(2):137. Unique Identifier : AIDSLINE MED/97229495
AIDS and electronic communications news.: Aids Patient Care STDS. 1996 Apr;10(2):138-9. Unique Identifier : AIDSLINE MED/97229497; Makulowich JS; john@trainer.com
A critical report from the Office of AIDS Research Advisory Council [editorial]: Aids Patient Care STDS. 1996 Apr;10(2):74-5. Unique Identifier : AIDSLINE MED/97229470; Laurence J
HIV infected women in Louisiana [letter]: Aids Patient Care STDS. 1996 Apr;10(2):76. Unique Identifier : AIDSLINE MED/97229471; King BJ
Chemical pleurodesis for spontaneous pneumothorax in a patient with AIDS.: Aids Patient Care STDS. 1996 Apr;10(2):77-8. Unique Identifier : AIDSLINE MED/97229472; Gerst PH; Mukherjee A; Rosario PG; Albu E; Department of Surgery, Bronx-Lebanon Hospital Center, NY, USA.; Persistent air leak and failure of the lung to expand completely after closed thoracostomy complicate the course of spontaneous pneumothorax in patients with AIDS. In such cases, attempts to discontinue chest tube drainage may fail. The following is a case of a patient with AIDS and spontaneous pneumothorax who respon
Adolescents and sexually transmitted diseases.: Aids Patient Care STDS. 1996 Apr;10(2):79-85. Unique Identifier : AIDSLINE MED/97229473; Hitchcock PJ; Sexually Transmitted Diseases Branch, National Institute of Allergy; and Infectious Diseases, Bethesda, MD 20892, USA.; This paper presents a brief overview of sexually transmitted diseases (STDs), including acquired immunodeficiency syndrome AIDS), in adolescent populations. Using the framework of a mathematical model (which considers how, why, and whether an infection spreads within a population), the epidemic of STDs among adolescen
CMV retinitis: a clinical management update.: Aids Patient Care STDS. 1996 Apr;10(2):86-93. Unique Identifier : AIDSLINE MED/97229474; Blanchet KD
Combating malnutrition in HIV infection.: Aids Patient Care STDS. 1996 Apr;10(2):94-100. Unique Identifier : AIDSLINE MED/97229475; Berger DS; Center for Special Immunology, University of Illinois at Chicago, USA.; Physicians should use nutrition as adjunctive therapy for all patients affected by HIV disease. However, when wasting is already present, a thorough evaluation (examination and labs) to elucidate and treat the underlying causes of malnutrition should be initiated, dietary counseling made available, and nutritional and
Receptor function of CD4 structures from African green monkey and pig-tail macaque for simian immunodeficiency virus, SIVsm, SIVagm, and human immunodeficiency virus type-1.: Viral Immunol. 1995;8(3):121-33. Unique Identifier : AIDSLINE MED/96430117; Fomsgaard A; Johnson PR; Nielsen C; Novembre FJ; Hansen J; Goldstein S; Hirsch VM; Department of Clinical Microbiology at Rigshospitalet, Statens; Seruminstitut, Copenhagen, Denmark.; Differences in kinetics of infection, cellular tropism, and cytopathology of SIV and HIV appear to depend on both viral and host factors. We investigated the role of critical CD4 structures from African green monkeys (AGM) a natural SIV host, from pig-tailed macaques (PT) an unnatural SIV host, and from humans, as wel
Human T-lymphotropic virus type I (HTLV-I)-specific antibodies and cell-free RNA in crevicular fluid-rich saliva from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy.: Viral Immunol. 1995;8(3):141-50. Unique Identifier : AIDSLINE MED/96430119; Soto-Ramirez LE; Garcia-Vallejo F; Renjifo B; Vergara A; Borrero I; Marlink R; Essex M; Department of Cancer Biology, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; Despite the likely role of mucosae in human T cell leukemia virus type I (HTLV-I) transmission, little is known about the mucosal immune response to HTLV-I. The present study evaluated the antibody response to HTLV-I in oral mucosa and the value of crevicular fluid rich saliva (CFRS) for diagnosing HTLV-I infection. C
Acquired immune dysfunction in rabbits experimentally infected with an infectious molecular clone of the bovine immunodeficiency virus (BIV127).: Viral Immunol. 1995;8(3):159-64. Unique Identifier : AIDSLINE MED/96430121; Kalvatchev Z; Walder R; Barrios M; Garzaro D; Laboratorio Virus Animales, Centro de Microbiologia y Biologia; Celular, Instituto Venezolano de Investigaciones Cientificas IVIC),; Caracas, Venezuela.; To investigate the effect of bovine immunodeficiency virus (BIV) infection on the rabbit immune system, we studied the proliferative responses of peripheral blood lymphocytes (PBLs) of rabbits experimentally inoculated with BIV. All BIV127-inoculated rabbits seroconverted after 6 weeks and remained seropositive over a
Development of cytomegalovirus (CMV) disease may be predicted in HIV-infected patients by CMV polymerase chain reaction and the antigenemia test.: AIDS. 1997 Mar;11(3):F21-8. Unique Identifier : AIDSLINE MED/97206883; Dodt KK; Jacobsen PH; Hofmann B; Meyer C; Kolmos HJ; Skinhoj P; Norrild B; Mathiesen L; Department of Infectious Diseases, Hvidovre Hospital, Denmark.; OBJECTIVE: Cytomegalovirus ( CMV ) is a frequent opportunistic viral pathogen in patients with AIDS leading to retinitis and other serious manifestations. CMV disease may be successfully treated. Prophylactic antiviral therapy has been shown to reduce the risk of
The development of resistance of HIV-1 to zalcitabine [editorial]: AIDS. 1997 Mar;11(3):271-9. Unique Identifier : AIDSLINE MED/97206884; Craig C; Moyle G
CD4+ T-cell recognition of diverse clade B HIV-1 isolates.: AIDS. 1997 Mar;11(3):281-8. Unique Identifier : AIDSLINE MED/97206885; Fernandez MH; Fidler SJ; Pitman RJ; Weber JN; Rees AD; Department of Genito-Urinary Medicine and Communicable Diseases,; Imperial College, School of Medicine, St Mary's Hospital, London, UK.; OBJECTIVES: To evaluate the effect of sequence variation within the gp120 V3 loop on CD4 T-cell recognition. DESIGN: CD4 T-cell clones were generated using synthetic peptides to circumvent the difficulties of using polyclonal T-cell responses. Peptides based on other HIV isolates were then used to determined the influ
Cerebral proton magnetic resonance spectroscopy in asymptomatic HIV infection.: AIDS. 1997 Mar;11(3):289-95. Unique Identifier : AIDSLINE MED/97206886; Wilkinson ID; Miller RF; Miszkiel KA; Paley MN; Hall-Craggs MA; Baldeweg T; Williams IG; Carter S; Newman SP; Kendall BE; Catalan J; Chinn RJ; Harrison MJ; Department of Medical Physics and Bioengineering, Middlesex Hospital,; University College London Hospitals, NHS Trust, UK.; OBJECTIVE: To determine whether proton magnetic resonance spectroscopy (MRS) demonstrates central nervous system abnormalities in asymptomatic HIV-1-infected individuals. DESIGN: Both prospective and retrospective cross-sectional analyses of MRS in asymptomatic HIV-infected individuals. SETTING: Two specialists HIV/AI
TAR and Sp1-independent transactivation of HIV long terminal repeat by the Tat protein in the presence of human cytomegalovirus IE1/IE2.: AIDS. 1997 Mar;11(3):297-303. Unique Identifier : AIDSLINE MED/97206887; Dal Monte P; Landini MP; Sinclair J; Virelizier JL; Michelson S; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; OBJECTIVE: The HIV Tat protein is a transcriptional transactivator of the HIV-1 long terminal repeat (LTR) promoter element. Its activity depends on its direct interaction with the trans-activation response (TAR) element, although TAR-independent activation by Tat has been demonstrated in different cells. Herpesviruse
Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals.: AIDS. 1997 Mar;11(3):305-10. Unique Identifier : AIDSLINE MED/97206888; Eugen-Olsen J; Iversen AK; Garred P; Koppelhus U; Pedersen C; Benfield TL; Sorensen AM; Katzenstein T; Dickmeiss E; Gerstoft J; Skinhoj P; Svejgaard A; Nielsen JO; Hofmann B; Department of Infectious Diseases, Copenhagen University Hospitals,; Hvidovre, Denmark.; OBJECTIVE: Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the dise
Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection.: AIDS. 1997 Mar;11(3):311-7. Unique Identifier : AIDSLINE MED/97206889; Chaisson RE; Keiser P; Pierce M; Fessel WJ; Ruskin J; Lahart C; Benson CA; Meek K; Siepman N; Craft JC; Department of Medicine, Johns Hopkins University, School of Medicine,; Baltimore 21287-6220, USA.; OBJECTIVE: To compare the efficacy of two- and three-drug regimens for treating Mycobacterium avium complex (MAC) bacteremia in patients with AIDS. DESIGN: Randomized open-label clinical trial. SETTING: Outpatient HIV specialty centers clinics. PATIENTS: A total of 106 adults with AIDS and MAC bacteremia. INTERVENTIO
Clinical features and outcomes of HIV-related cytomegalovirus pneumonia.: AIDS. 1997 Mar;11(3):319-24. Unique Identifier : AIDSLINE MED/97206890; Salomon N; Gomez T; Perlman DC; Laya L; Eber C; Mildvan D; Department of Medicine, Beth Israel Medical Center, New York, New York; 10003, USA.; OBJECTIVE: To describe the characteristics and outcomes of HIV-infected patients with biopsy-proven cytomegalovirus ( CMV ) pneumonia. DESIGN: Retrospective study. SETTING: A 900-bed acute facility in New York City. PATIENTS: E
Vitamin A deficiency and maternal-infant transmissions of HIV in two metropolitan areas in the United States.: AIDS. 1997 Mar;11(3):325-32. Unique Identifier : AIDSLINE MED/97206891; Greenberg BL; Semba RD; Vink PE; Farley JJ; Sivapalasingam M; Steketee RW; Thea DM; Schoenbaum EE; Department of Epidemiology and Social Medicine, Montefiore Medical; Center/Albert Einstein College of Medicine, Bronx, New York 10467,; USA.; OBJECTIVE: To determine whether vitamin A deficiency is associated with maternal-infant HIV transmission among HIV-infected pregnant women in two United States cities. METHODS: Third trimester serum vitamin A levels were evaluated using high-performance liquid chromatography in 133 HIV
Pregnancy and contraception in a French cohort of HIV-infected women. SEROCO Study Group.: AIDS. 1997 Mar;11(3):333-8. Unique Identifier : AIDSLINE MED/97206892; De Vincenzi I; Jadand C; Couturier E; Brunet JB; Gallais H; Gastaut JA; Goujard C; Deveau C; Meyer L; European Centre for the Epidemiological Monitoring of AIDS, National; Hospital of Saint-Maurice, Saint-Maurice, France.; OBJECTIVE: To describe the impact of HIV diagnosis on contraception, incidence of pregnancy and live-births among HIV-infected women in France . DESIGN: Follow-up of women included in a French cohort of HIV-infected adults (SEROCO). METHODS: In 17 hospital-based units and one privat
The HIV epidemic in Zambia: socio-demographic prevalence patterns and indications of trends among childbearing women.: AIDS. 1997 Mar;11(3):339-45. Unique Identifier : AIDSLINE MED/97206893; Fylkesnes K; Musonda RM; Kasumba K; Ndhlovu Z; Mluanda F; Kaetano L; Chipaila CC; Epidemiology and Research Unit, National AIDS, STD, TB & Leprosy; Programme, Lusaka, Zambia.; OBJECTIVE: To examine socio-demographic HIV prevalence patterns and trends among childbearing women in Zambia . DESIGN: Repeated cross-sectional surveys. METHODS: Personal interviews and unlinked anonymous testing of blood samples of women attending antenatal care in selected areas.
Cost-effectiveness of HIV-prevention skills training for men who have sex with men.: AIDS. 1997 Mar;11(3):347-57. Unique Identifier : AIDSLINE MED/97206894; Pinkerton SD; Holtgrave DR; Valdiserri RO; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee, Wisconsin 53202, USA.; OBJECTIVE: A previous study empirically compared the effects of two HIV-prevention interventions for men who have sex with men: i) a safer sex lecture, and (ii) the same lecture coupled with a 1.5 h skills-training group session. The skills-training intervention led to a significant increase in condom use at 12-month
Sexually transmitted disease (STD) and HIV risk in heterosexual adults attending a public STD clinic: evaluation of a randomized controlled behavioral risk-reduction intervention trial.: AIDS. 1997 Mar;11(3):359-67. Unique Identifier : AIDSLINE MED/97206895; Boyer CB; Barrett DC; Peterman TA; Bolan G; Department of Pediatrics, University of California, San Francisco; 94143, USA.; OBJECTIVE: To evaluate the efficacy of a cognitive/behavioral skills-building intervention to prevent sexually transmitted diseases (STD) in high-risk heterosexual adults. DESIGN: A randomized controlled trial with assessments at baseline, and at 3 and 5 months. SETTING: San Francisco STD Clinic. PATIENTS: A total of
Field evaluation of rapid HIV serologic tests for screening and confirming HIV-1 infection in Honduras.: AIDS. 1997 Mar;11(3):369-75. Unique Identifier : AIDSLINE MED/97206896; Stetler HC; Granade TC; Nunez CA; Meza R; Terrell S; Amador L; George JR; Division of AIDS, National Center for Infectious Diseases, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; OBJECTIVE: To determine the ability of simple, rapid tests to identify HIV-1 antibody-positive specimens in field settings using the World Health Organization s (WHO) alternative testing strategies. DESIGN: Three-phase evaluation of simple, rapid assays using banked specimens and prospectively collected serum specimen
On-site HIV testing in resource-poor settings: is one rapid test enough?: AIDS. 1997 Mar;11(3):377-81. Unique Identifier : AIDSLINE MED/97206897; Wilkinson D; Wilkinson N; Lombard C; Martin D; Smith A; Floyd K; Ballard R; Centre for Epidemiological Research in Southern Africa, Medical; Research Council, Hlabisa Hospital, South Africa.; OBJECTIVE: To determine the feasibility, accuracy and cost-effectiveness of a rapid, on-site, HIV testing strategy in a rural hospital, and to assess its impact on test turnaround time and the proportion of patients post-test counselled. DESIGN: Prospective comparison of two testing strategies [double rapid test on-si
Elevated interferon-alpha in maternal and umbilical cord blood and in the placental trophoblast suggests natural protection against vertical transmission of HIV-1 in a Kenyan cohort [letter]: AIDS. 1997 Mar;11(3):383-5. Unique Identifier : AIDSLINE MED/97206898; Zachar V; Hager H; Koppelhus U; Zacharova V; Liu X; Bambra C; Goustin AS; Ebbesen P
Disseminated microsporidiosis in AIDS: are any organs spared? [letter]: AIDS. 1997 Mar;11(3):385-6. Unique Identifier : AIDSLINE MED/97206899; Orenstein JM; Gaetz HP; Yachnis AT; Frankel SS; Mertens RB; Didier ES
Comparison of fluorescence and standard light microscopy for diagnosis of microsporidia in stools of patients with AIDS and chronic diarrhoea [letter]: AIDS. 1997 Mar;11(3):386-7. Unique Identifier : AIDSLINE MED/97206900; Conteas C; Donovan J; Berlin OG; Sowerby TM; La Riviere M
Human chorionic gonadotrophin in the treatment of HIV-related Kaposi's sarcoma [letter]: AIDS. 1997 Mar;11(3):387-8. Unique Identifier : AIDSLINE MED/97206901; Tirelli U; Tavio M; Giacca M; De Paoli P
Unusual occurrence of spontaneous haematomas in three asymptomatic HIV-infected haemophilia patients a few days after the onset of ritonavir treatment [letter]: AIDS. 1997 Mar;11(3):388-9. Unique Identifier : AIDSLINE MED/97206902; Ginsburg C; Salmon-Ceron D; Vassilief D; Rabian C; Rotschild C; Fontenay-Roupie M; Stieltjes N; Sicard D
HIV-1 subtypes A and B isolated from the Republic of Korea [letter]: AIDS. 1997 Mar;11(3):389-91. Unique Identifier : AIDSLINE MED/97206903; de Souza M; Song MS; Carr JK; Sanders-Buell E; Shin Y; Artenstein AW; Lee H; McCutchan FE; Brown AE
Short-term response to indinavir in patients with advanced HIV disease with prior heavy exposure to nucleoside analogues [letter]: AIDS. 1997 Mar;11(3):391-2. Unique Identifier : AIDSLINE MED/97206904; Soriano V; Gomez-Cano M; Adrados M; Castilla J; Villalba N; Laguna F; Gonzalez-Lahoz J
The efficacy of nonoxynol-9 from an in vivo point of view [letter]: AIDS. 1997 Mar;11(3):392-4. Unique Identifier : AIDSLINE MED/97206905; Wittkowski KM
Strongyloides stercoralis hyperinfection diagnosed by gastric cytology in an AIDS patient [letter]: AIDS. 1997 Mar;11(3):394-6. Unique Identifier : AIDSLINE MED/97206906; Sarangarajan R; Belmonte AH; Tchertkoff V
Evidence for the selective pressure to reduce heterogeneity of HIV-1 subtype E envelope V3-loop sequences in an intrafamilial infection case [letter]: AIDS. 1997 Mar;11(3):396-7. Unique Identifier : AIDSLINE MED/97206907; Sato H; Taniguchi K; Tomita Y; Shiino T; Miyakuni T; Takebe Y
Re-evaluation of time to progression of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients clinically resistant to ganciclovir [letter]: AIDS. 1997 Mar;11(3):397-9. Unique Identifier : AIDSLINE MED/97206908; Mueller AJ; Jacobson MA; Hurwitz S; Chuang EL; Friedberg DN; Haidt SJ; Heinemann MH; Jabs DA; Kaplan HJ; Freeman WR
Response of HIV-associated thrombocytopenia to triple agent antiretroviral therapy [letter]: AIDS. 1997 Mar;11(3):399-400. Unique Identifier : AIDSLINE MED/97206909; Walsh JC; Costello CE; Nelson MR
Relapses of chronic hepatitis C in HIV-infected patients who responded to interferon therapy. Hepatitis/HIV Spanish Study Group [letter]: AIDS. 1997 Mar;11(3):400-1. Unique Identifier : AIDSLINE MED/97206910; Soriano V; Bravo R; Garcia-Samaniego J; Castilla J; Gonzalez J; Castro A; Llibre JM
HIV infection in Madagascar in 1995 [letter]: AIDS. 1997 Mar;11(3):401-2. Unique Identifier : AIDSLINE MED/97206911; Zeller HG; Ramamonjisoa A; Boisier P; Ravelojaona B; Brutus L; Randriamanga R; Rabarijaona L; Rakoto-Andrianarivelo M; Auregan G; Behets F; Roux JF; Rasamindrakotroka AJ
Male circumcision and susceptibility to HIV infection among men in Tanzania [corrected and republished article originally printed in AIDS 1997 Jan;11(1):73-9]: AIDS. 1997 Mar;11(3):73-80. Unique Identifier : AIDSLINE MED/97287620; Urassa M; Todd J; Boerma JT; Hayes R; Isingo R; Tanzania-Netherlands Project to Support AIDS Control in Mwanza region,; African Medical and Research Foundation, Mwanza, Tanzania.; BACKGROUND: Evidence from ecological studies and from studies of and sexually transmitted disease (STD) patients in sub-Saharan Africa suggests that there is a protective effect of male circumcision against HIV infection. There are, however, few population-based studies that have controlled adequately for potential co
Development of HIV-1 protease expression methods using the T7 phage promoter system.: Appl Microbiol Biotechnol. 1997 Mar;47(3):241-5. Unique Identifier : AIDSLINE MED/97269383; Komai T; Ishikawa Y; Yagi R; Suzuki-Sunagawa H; Nishigaki T; Handa H; Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.; New and simple human immunodeficiency virus type 1 (HIV-1) protease expression methods in Escherichia coli were developed using the T7 phage promoter system. In order to suppress leaky HIV-1 protease expression under the control of the T7 polymerase, two new methods were tested. One involved the introduction of supple
Inhibition of specific IgE response in vivo by allergen-gene transfer.: Int Immunol. 1996 Sep;8(9):1405-11. Unique Identifier : AIDSLINE MED/97079707; Hsu CH; Chua KY; Tao MH; Huang SK; Hsieh KH; Graduate Institute of Microbiology, College of Medicine, National; Taiwan University, Taipai, ROC.; DNA immunization has been an attractive approach in altering the host immune response to antigen. To examine the utility of DNA immunization in allergic response, we examined the in vivo efficacy of an allergen-gene immunization approach in the modulation of allergen-specific IgE responses in mice. Our results showe
Reasons given by patients for "non-progression' in HIV infection.: AIDS Care. 1997 Apr;9(2):133-42. Unique Identifier : AIDSLINE MED/97281321; Troop M; Easterbrook P; Thornton S; Flynn R; Gazzard B; Catalan J; Chelsea & Westminster Hospital, London, UK.; Identification of the reasons for long-term survival in HIV infection is an area of current intense research. The objective of this study was to determine the perceptions among patients with different rates of disease progression as to the reasons for a good outcome with HIV. In a case-control study of 134 long-term >
Prediction of the healthcare needs of persons with HIV/AIDS from preliminary health assessment information.: AIDS Care. 1997 Apr;9(2):143-60. Unique Identifier : AIDSLINE MED/97281322; Berk RA; Nanda JP; School of Nursing, Johns Hopkins University, Baltimore, Maryland; 21205, USA.; The authors present evidence on the utility of standard health assessment information (i.e. health status, behavioural, and sociodemographic characteristics) collected by nurses for predicting the psychosocial and physiological healthcare needs of persons with HIV/AIDS in four clinical settings. A cross-sectional desc
HIV diagnosis rituals and identity narratives.: AIDS Care. 1997 Apr;9(2):161-79. Unique Identifier : AIDSLINE MED/97281323; Roth NL; Nelson MS; SCILS, Rutgers University, New Brunswick, New Jersey 08901-1071, USA.; nroth@scils.rugers.edu; Using the constitutive view of health communication as a framework, this essay explores the construction of HIV diagnoses in narratives about physician/patient interactions. Narrative analysis reveals the life-changing impact of HIV diagnosis and the incongruence of the routine ways in which most diagnoses are handled
Correlates of condom use among female prostitutes and tourist clients in Bali, Indonesia.: AIDS Care. 1997 Apr;9(2):181-97. Unique Identifier : AIDSLINE MED/97281324; Thorpe L; Ford K; Fajans P; Wirawan DN; School of Public Health, University of Illinois, Chicago 60612, USA.; lthorpe@uic.edu; This study examines the commercial sex activity of both tourist client and local prostitute groups in the host country of Indonesia . The study provides a profile of social and behavioural characteristics of foreign tourist men and Indonesian women engaging in commercial sex, usi
Sexual networks in Uganda: casual and commercial sex in a trading town.: AIDS Care. 1997 Apr;9(2):199-207. Unique Identifier : AIDSLINE MED/97281325; Pickering H; Okongo M; Nnalusiba B; Bwanika K; Whitworth J; Medical Research Council/Uganda Virus Research Institute, Entebbe,; Uganda.; A longitudinal study of the sexual behaviour of high-risk men and women living in a trading town on the trans-Africa highway showed that distinct sexual networks operated within the town. Forty-eight prostitutes kept daily records for 6 months of all their sexual contacts including the occupation and place of residenc
HIV antibody testing: Genito-Urinary Clinic or additional site same-day testing service.: AIDS Care. 1997 Apr;9(2):209-15. Unique Identifier : AIDSLINE MED/97281326; Hudson MM; Nelson WL; Ronalds CJ; Anderson J; Jeffries DJ; Department of Genito-Urinary Medicine, St Bartholomew's Hospital,; London, UK.; It has been suggested that different groups of individuals, possibly those at greater risk, may choose to attend anonymous HIV services not attached to Genito-Urinary Medicine Clinics. This paper reports the results of a comparative study of documented sociodemographic profile and risk category for individuals having
Younger versus older gay men: risks, pleasures and dangers of anal sex.: AIDS Care. 1997 Apr;9(2):217-25. Unique Identifier : AIDSLINE MED/97281327; Vincke J; Bolton R; Miller M; Department of Sociology, University of Ghent, Belgium.; This study reports on the practice and the pleasure and danger perceptions of protected and unprotected anal sex of young adult gay men (
Social factors and the process of risk construction in HIV sexual transmission.: AIDS Care. 1997 Apr;9(2):227-37. Unique Identifier : AIDSLINE MED/97281328; Bajos N; INSERM U 292, Hopital de Bicetre, Le Kremlin Bicetre, France.; This paper reviews different approaches used to analyse the process of risk construction as concerns the sexual transmission of HIV. Individualistic approaches focus on understanding how individual risk representation is constructed. Constructivist approaches consider that the process of risk construction occurs in re
World Health Organization Global AIDS Statistics.: AIDS Care. 1997 Apr;9(2):251-5. Unique Identifier : AIDSLINE MED/97281329
[Pulmonary nocardiosis: presentation of 3 clinical cases]: Enferm Infecc Microbiol Clin. 1997 Jan;15(1):19-21. Unique Identifier : AIDSLINE MED/97194205; Ugedo J; Perez A; Orcastegui JL; Ruiz C; Gomez R; Garcia C; Servicio de Neumologia, Hospital Clinico Universitario Lozano Blesa,; Zaragoza.; INTRODUCTION: Nocardiosis is an infectious disease that frequently involves to the respiratory tract. Nocardia asteroides is the predominant human pathogen. Nocardiosis is difficult to diagnose and that s why its incidence is not well established. CASES: Three cases diagnosed in a Pneumology Section are reported. None
[Cerebral SPECT with thallium-201 in the differential diagnosis of focal cerebral lesions in patients with AIDS]: Enferm Infecc Microbiol Clin. 1997 Jan;15(1):28-31. Unique Identifier : AIDSLINE MED/97194208; Sanjaume M; Rodriguez-Carballeira M; Mauri E; Martinez-Lacasa J; Garcia JR; Garau J; Servicio de Medicina Interna, Hospital Mutua de Terrassa, Barcelona.; BACKGROUND: The aim of this study was to analyze the usefulness of cerebral SPECT with thallium-201 in patients with the acquired human immunodeficiency syndrome (AIDS) and focal cerebral lesions. METHODS: Six patients with AIDS and focal cerebral lesions in whom a cerebral SPECT was performed with thallium-201 are de
[Fever and pulmonary nodules in patients with HIV infection]: Enferm Infecc Microbiol Clin. 1997 Jan;15(1):41-2. Unique Identifier : AIDSLINE MED/97194211; Roig R; Perez-Garcia L; Orti A; Crespo C; Gonzalez-Alvarez I; Marco Such J; Servicios de Medicina Interna, Hospital de San Juan, Alicante.
[Pulmonary infection by Mycobacterium malmoense in a patient with AIDS (letter)]: Enferm Infecc Microbiol Clin. 1997 Jan;15(1):47-8. Unique Identifier : AIDSLINE MED/97194217; Lopez R; Redondo MP; Ruiz D; Geijo P
[Infection by Bordetella bronchiseptica in patients with AIDS letter; comment)]: Enferm Infecc Microbiol Clin. 1997 Jan;15(1):48-9. Unique Identifier : AIDSLINE MED/97194218; Goenaga MA; Arrizabalaga J; Iribarren JA; Rodriguez-Arrondo F; von Wichmann MA
Hepatitis C antibody positive: what next? [editorial] [published erratum appears in Int J STD AIDS 1997 Mar;8(3):149]: Int J STD AIDS. 1997 Jan;8(1):1-4. Unique Identifier : AIDSLINE MED/97196885; Newell AN; Nelson MR
Peripheral neuropathy in HIV.: Int J STD AIDS. 1997 Jan;8(1):16-21; quiz 22. Unique Identifier : AIDSLINE MED/97196887; Sadler M; Nelson M; Chelsea and Westminster NHS Trust, London, UK.
Hormonal factors and the laboratory detection of Chlamydia trachomatis in women: implications for screening?: Int J STD AIDS. 1997 Jan;8(1):25-31. Unique Identifier : AIDSLINE MED/97196888; Crowley T; Horner P; Hughes A; Berry J; Paul I; Caul O; Department of Genitourinary Medicine, Bristol Royal Infirmary, UK.; One thousand and fifty-six new and re-registered consecutive women attending a genitourinary medicine clinic requiring speculum examination were screened for Chlamydia trachomatis by enzyme immunoassay (IDEIA, Dako Diagnostics Ltd). Of 1022 women who had results available for both cervix and urethra C. trachomatis was
Heterosexual gonorrhoea at St Thomas'--I: Patient characteristics and implications for targeted STD and HIV prevention strategies.: Int J STD AIDS. 1997 Jan;8(1):32-5. Unique Identifier : AIDSLINE MED/97196889; Daker-White G; Barlow D; Department of Genitourinary Medicine, St Thomas' Hospital, London, UK.; This paper compares the socio-demographic characteristics of patients with gonorrhoea with a control group of other attendees to an inner-London genitourinary medicine (GUM) clinic. Between 16 May and 21 December 1994 inclusive there were 312 culture-confirmed heterosexually-acquired cases of Neisseria gonorrheae trea
To test or not to test, could you repeat the question?: Int J STD AIDS. 1997 Jan;8(1):36-9. Unique Identifier : AIDSLINE MED/97196890; Meyrick J; Lawrence AG; Barton SE; Boag FC; Chelsea and Westminster Hospital, London, UK.; We aimed to investigate clinical practice in the offering of HIV tests and subsequent uptake in a central London genitourinary medicine (GUM) clinic. A random sample (n = 330) of attenders at 3 inner-London GUM departments was surveyed. Reasons for and rates of offering of HIV tests were recorded and analysed in relat
Promoting condom-only brothels through solidarity and support for brothel managers.: Int J STD AIDS. 1997 Jan;8(1):40-3. Unique Identifier : AIDSLINE MED/97196891; Sakondhavat C; Werawatanakul Y; Bennett A; Kuchaisit C; Suntharapa S; Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon; Kaen University, Thailand.; Brothel workers in Thailand are at high risk of HIV infection but they alone do not have adequate bargaining power to insist on condom use with all clients. Brothel managers, on the other hand, are a source of influence over both clients and their workers and can promote universa
Travels with HIV: the compliance and health of HIV-infected adults who travel.: Int J STD AIDS. 1997 Jan;8(1):44-9. Unique Identifier : AIDSLINE MED/97196892; Kemper CA; Linett A; Kane C; Deresinski SC; Department of Medicine, Santa Clara Valley Medical Center, San Jose,; CA 95128, USA.; We examined the effects of travel on the health of a group of HIV-infected adults (n = 89) cared for in a public hospital HIV clinic. In a period of 2 years, 45% travelled to a median of 3 US destinations for at least one week and 20% travelled to at least one international destination for a mean duration of 20 days.
Bacterial infections in HIV: the extent and nature of the problem [editorial]: Int J STD AIDS. 1997 Jan;8(1):5-15. Unique Identifier : AIDSLINE MED/97196886; Brettle RP; Leucopenia and neutropenia in HIV appears to be much less common than in the context of haematological malignancies although severe neutropenia (
The cost of health care for HIV-positive patients.: Int J STD AIDS. 1997 Jan;8(1):50-3. Unique Identifier : AIDSLINE MED/97196893; Brettle RP; Atkinson FI; Wilcock J; Richardson A; Lewis R; MacCallum L; Bath G; Regional Infectious Disease Unit, City Hospital Edinburgh, UK.; Utilizing a prospective study of health service activity for HIV/AIDS, 2 estimates of hospital costs of care analysed with reference to gender, risk activity, immunological and clinical staging (1987 definition of AIDS) were undertaken. Utilizing combined costs per life year (based on hospital and hospice activity but
Donovanosis: treatment with azithromycin.: Int J STD AIDS. 1997 Jan;8(1):54-6. Unique Identifier : AIDSLINE MED/97196894; Arevalo Morles C; Hernandez I; Ferreiro MC; Venereology Center, Medicine Faculty, UCV, Caracas, Venezuela.
Metronidazole hypersensitivity in a patient with bacterial vaginosis.: Int J STD AIDS. 1997 Jan;8(1):57-8. Unique Identifier : AIDSLINE MED/97196895; Bhaduri S; Riley VC; Department of Genito-Urinary Medicine, Leicester Royal Infirmary, UK.
Recurrent Helicobacter cinaedi cellulitis and bacteraemia in a patient with HIV Infection.: Int J STD AIDS. 1997 Jan;8(1):59-60. Unique Identifier : AIDSLINE MED/97196896; Sullivan AK; Nelson MR; Walsh J; Gazzard BG; Chelsea and Westminster Hospital, London, UK.
Obstructive renal failure requiring surgical intervention in an AIDS patient being treated with sulphadiazine.: Int J STD AIDS. 1997 Jan;8(1):61-2. Unique Identifier : AIDSLINE MED/97196897; Mir N; O'Farrell N; Creagh TA; Knowles C; Department of Genitourinary Medicine, St Thomas' Hospital, London, UK.
Audit of a policy to improve communication with patients who default.: Int J STD AIDS. 1997 Jan;8(1):63. Unique Identifier : AIDSLINE MED/97196898; Stevenson MM; Huengsberg M; Radcliffe KW; Department of Genito-Urinary Medicine, South Birmingham Community; Health Trust, UK.
Is one diagnostic testing of multiple sites enough to detect gonorrhoea infection in women?: Int J STD AIDS. 1997 Jan;8(1):64-5. Unique Identifier : AIDSLINE MED/97196899; Harry TC; Rashid S; Saravanamuttu KM; Shrestha TL; Roberts SA; Department of Genito-Urinary Medicine, Sunderland Hospital, UK.
Cervicovaginal HIV-1 and HIV-2 cross-reactivities [letter]: Int J STD AIDS. 1997 Jan;8(1):68. Unique Identifier : AIDSLINE MED/97196900; Belec L; Dupre T; Tevi-Benissan C; Prazuck T; Becquart P; Hocini H; Gilquin J
Herpes simplex type 1 and genital herpes in Northern Ireland [letter]: Int J STD AIDS. 1997 Jan;8(1):68-9. Unique Identifier : AIDSLINE MED/97196901; Christie SN; McCaughey C; McBride M; Coyle PV
Condom breakage and prevention of HIV transmission: an underestimated problem [letter]: Int J STD AIDS. 1997 Jan;8(1):69-70. Unique Identifier : AIDSLINE MED/97196902; Eich-Hochli D; Niklowitz MW; Sieber M; Opravil M; Luthy R
Expression of CD45-restricted form B in (NZW x BXSB) F1 and MRL/Mp-lpr/lpr mice.: Autoimmunity. 1996;24(4):237-46. Unique Identifier : AIDSLINE MED/97205734; Sugihara A; Adachi Y; Inaba M; Inaba K; Miyashima S; Yamamoto Y; Hayashi H; Genba H; Horio T; Ikehara S; First Department of Pathology, Kansai Medical University, Osaka,; Japan.; Expression of CD45RB on CD4+ or CD8+ cells in combination with TCRV beta usages (V beta 6, V beta 8.1, V beta 8.2, V beta 11 and V beta 17a) in normal mouse strains (BALD/c and C57BL/6) was compared with autoimmune-prone strains (NZW x BXSB) F1 and MRL/lpr) at young and old ages. The frequencies, and also the numbers
Spectroscopic investigations of HIV-1 trans-activator and related peptides in aqueous solutions.: Biophys Chem. 1997 Jan 31;63(2-3):87-96. Unique Identifier : AIDSLINE MED/97262311; Klostermeier D; Bayer P; Kraft M; Frank RW; Rosch P; Lehrstuhl fur Biopolymere, Universitat Bayreuth, Germany.; The 86 amino acid trans-activator (Tat) protein of human immunodeficiency virus type 1 (HIV-1) is an RNA-binding transcriptional regulator. HIV-1 Tat proteins (wild type and Thr40Lys mutant) and the HIV-1 Tat peptide fragments Tat(32-48) and Tat(32-72) were chemically synthesized. One- and two-dimensional nuclear magn
New approaches to using antiretroviral therapy for the management of HIV Infection.: Ann Pharmacother. 1997 Feb;31(2):228-36. Unique Identifier : AIDSLINE MED/97186971; Doran CM; School of Pharmacy, University of Wisconsin, University of Wisconsin; Hospitals and Clinics HIV Care Program, Madison 53706, USA.; cmh@pharmacy.wisc.edu; OBJECTIVE: To review the changes that have occurred in the past 2 years in the management of HIV infection with antiretroviral agents by contrasting the 1994 with the 1996 Guidelines. DATA SOURCES: Conference proceedings, clinical experience of the author and her colleagues, and English-language articles from the body
Azole resistance in yeasts [letter]: Ann Pharmacother. 1997 Feb;31(2):255. Unique Identifier : AIDSLINE MED/97186982; Craig JM; Nash CL; Kinghorn GR
The HIV/AIDS epidemics among drug injectors: a study of contact structure through a mathematical model.: Math Biosci. 1997 Jan 1;139(1):25-58. Unique Identifier : AIDSLINE MED/97265954; Iannelli M; Milner FA; Pugliese A; Gonzo M; Dipartimento di Matematica, Universita di Trento, Povo, Italy.; Numerical results of a model with variable infectivity for the dynamics of HIV/AIDS (human immunodeficiency virus/acquired immune deficiency syndrome) have been compared with the data of AIDS cases among intravenous drug users in Italy , especially in the Latium region. We examined s
Antigenic diversity thresholds and hazard functions.: Math Biosci. 1997 Jan 1;139(1):59-68. Unique Identifier : AIDSLINE MED/97265955; May RM; Stekel DJ; Nowak MA; Department of Zoology, University of Oxford, England.; In this paper, we answer some points made in a recent paper by N.I. Stilianakis and coworkers on the antigenic diversity threshold model for acquired immune deficiency syndrome pathogenesis. An extended version of the model is then used to compute hazard functions for the human immunodeficiency virus incubation period
Roles of the JAK-STAT system in signal transduction via cytokine receptors.: Curr Opin Genet Dev. 1996 Oct;6(5):587-96. Unique Identifier : AIDSLINE MED/97094615; Watanabe S; Arai Ki; Department of Molecular and Development Biology, Institute of Medical; Science, University of Tokyo, Minato-ku, Tokyo, Japan.; sumiko@ims.u-tokyo.ac.jp; JAK-STAT signaling pathways are known to play an essential role in the specific activation of interferon-inducible genes. Many cytokines interacting with the cytokine receptor superfamily also appear to activate these pathways. Recent evidence indicates that JAKs play an essential role(s) in cytokine receptor signalin
Regulation of cytokine expression by human blood basophils.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):134-7. Unique Identifier : AIDSLINE MED/97276810; Dahinden CA; Rihs S; Ochsensberger B; Institute of Immunology and Allergology, Inselspital, University of; Bern, Switzerland. dahinden@insel.ch; IL-4 and IL-13 are key immunoregulatory cytokines because of their ability to induce and amplify Th2-type immune responses and by promoting IgE formation. The basophil is a particularly prominent source of IL-4/IL-13, which are rapidly produced upon Fc epsilonRI cross-linking. Cytokine expression by basophils is uniqu
An update on human Th1 and Th2 cells.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):153-6. Unique Identifier : AIDSLINE MED/97276815; Romagnani S; Parronchi P; D'Elios MM; Romagnani P; Annunziato F; Piccinni MP; Manetti R; Sampognaro S; Mavilia C; De Carli M; Maggi E; Del Prete GF; Division of Clinical Immunology and Allergy, Institute of Internal; Medicine and Immunoallergology, University of Florence, Italy.; The existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic cell subset has been established. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and
In vitro maturation of naive human CD4+ T lymphocytes into Th1, Th2 effectors.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):157-9. Unique Identifier : AIDSLINE MED/97276816; Delespesse G; Demeure CE; Yang LP; Ohshima Y; Byun DG; Shu U; University of Montreal, Centre de Recherches Louis-Charles Simard,; Notre-Dame Hospital, Montreal, Quebec, Canada.
Depletion of CD8+ T cells following primary immunization with ovalbumin results in a high and persistent IgE response.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):160-2. Unique Identifier : AIDSLINE MED/97276817; Holmes BJ; MacAry PA; Kemeny DM; Department of Immunology, King's College School of Medicine and; Dentistry, London, UK.; The role of CD8+ T cells in the regulation of IgE was investigated by in vivo CD8+ T-cell depletion. Following intraperitoneal immunization with ovalbumin (OVA), OVA-specific T cell responses were first detected in the draining lymph nodes LN) and subsequently in the spleen. In vitro depletion of LN CD8+ cells reduced
Are differentiated human T helper cells reversible?: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):163-6. Unique Identifier : AIDSLINE MED/97276818; Seder RA; Prussin C; Laboratory of Clinical Investigation, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda, Md.; 20892, USA. rseder@nih.gov; Cytokines and cytokine antagonists have important roles in controlling the type of immune response generated. These mediators have the most profound effects if used at the initiation of an immune response. For example, IL-4 and IL-12 are important determinants in the generation of Th1 and Th2 cells, respectively, in b
Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):227-30. Unique Identifier : AIDSLINE MED/97276837; Lee DJ; Tighe H; Corr M; Roman M; Carson DA; Spiegelberg HL; Raz E; University of California, San Diego, School of Medicine, La Jolla; 92093-0831, USA.; BACKGROUND: We previously showed that immunization of mice with plasmid DNA (pDNA) encoding the Escherichia coli beta-galactosidase gene (pCMV-LacZ) induces a Th1 response, whereas beta-galactosidase (beta-gal) in saline or alum induces a Th2 response. Furthermore, the Th1 response dominates over the Th2 response and
IFN-gamma production from human Th1 cells is controlled by Raf kinase.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):275-8. Unique Identifier : AIDSLINE MED/97276854; Webber S; Zheng R; Kamal A; Withnall M; Karlsson JA; Department of Pharmacology, Rhone-Poulenc Rorer Ltd., Dagenham; Research Centre, UK.; Raf kinase is an important intracellular mediator in T cell signalling and may be crucial for the proliferation of this inflammatory cell. In order to elucidate its effect on cytokine production by human T cells in response to T cell receptor activation, experiments were carried out on human T cell clones using antise
Generation of rat MHC class-I-restricted ovalbumin-specific IgE inhibitory CD8+ T cell clones.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):279-80. Unique Identifier : AIDSLINE MED/97276855; MacAry PA; Holmes BJ; Kemeny DM; Department of Immunology, King's College School of Medicine and; Dentistry, Rayne Institute, London, UK.; Allergic disease presents an increasing health problem in industrialised countries. Despite improved diagnosis and drug therapy, the number of fatalities from asthma and anaphylaxis continues to rise. A key element in the aetiology of the allergic response to inert protein antigens is an inherent imbalance in the atop
Exogenous IL-12 and directed induction of human and murine Th1-associated responses.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):281-3. Unique Identifier : AIDSLINE MED/97276856; HayGlass KT; Li Y; Rempel JD; Wang M; Simons FE; Department of Immunology, University of Manitoba, Winnipeg, Canada.; HAYGLASS@BLDGHSC.LAN1.UMANITOBA.CA
Human mast cells modulate proliferation and cytokine production by CD8+ T lymphocytes.: Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):287-8. Unique Identifier : AIDSLINE MED/97276858; de Pater-Huijsen FL; de Riemer MJ; Reijneke RM; Pompen M; Lutter R; Jansen HM; Out TA; Department of Pulmonology, Academic Medical Center, Amsterdam, The; Netherlands.
Discovering the causes of atopy [editorial; comment]: BMJ. 1997 Apr 5;314(7086):987-8. Unique Identifier : AIDSLINE MED/97267503; Shaheen S
EU makes a difference over AIDS [news]: BMJ. 1997 Apr 5;314(7086):997. Unique Identifier : AIDSLINE MED/97267512; Watson R
Economic consequences of HIV/AIDS in India.: Natl Med J India. 1997 Jan-Feb;10(1):27-30. Unique Identifier : AIDSLINE MED/97222709; Pandav CS; Anand K; Shamanna BR; Chowdhury S; Nath LM; All India Institute of Medical Sciences, Ansari Nagar, New Delhi,; India.; BACKGROUND: HIV/AIDS is one of the pressing public health problems in India . Available information indicates a rising trend of infection. The impact of HIV/AIDS on the economic front is important as it affects mainly the young, who are in the reproductive age group. We estimated the
[Preliminary screening for antiviral AIDS drugs. VI. Report for fiscal year 1993]: Eisei Shikenjo Hokoku. 1996;(114):48-9. Unique Identifier : AIDSLINE MED/97189750; Ushijima H; Takahashi K; Kunisada T; Moritugu Y; Kobayashi N; Noguchi Y; Matsuyama M; Akiyoshi K; Noro S; Sawada H; Sakurada N; Yamada A; Ishizaki T; Kamimura N; Yoshida Y; Ono T; Ohtomo N; Morishita T; Kobayashi S; Miyake T; Ishiwara Y; Suzuki R; Saito T; Etoh S; Mise K; et al; Preliminary screening of antiviral AIDS drugs has been carried out using three different in vitro assay systems. Among 138 samples tested, two were found to inhibit the growth of HIV in vitro. Neither of the positive samples has hopeful signs, as the ranges of effective doses of the samples are very narrow.
[Preliminary screening for antiviral AIDS drugs. VII. Report for fiscal year 1994]: Eisei Shikenjo Hokoku. 1996;(114):50-2. Unique Identifier : AIDSLINE MED/97189751; Ohmuki N; Kazama K; Sadamasu T; Sekine H; Ohta K; Kudoh Y; Kobayashi N; Noguchi Y; Matsuyama M; Akiyoshi K; Noro S; Sawada H; Kimura H; Yamada A; Ishizaki T; Kamimura N; Yoshida Y; Ono T; Tachibana N; Morishita T; Kobayashi S; Miyake T; Ishiwara Y; Ishikawa N; Moritugu Y; et al; Preliminary screening of antiviral AIDS drugs has been carried out using three different in vitro assay systems. Among 246 samples of different origin tested, six were shown to inhibit the growth of HIV in vitro. Two of the positive samples have hopeful signs, as the ranges of effective doses are wider than those of m
Unlinked anonymous monitoring of HIV prevalence in England and Wales-data to the end of 1995.: Commun Dis Rep CDR Wkly. 1996 Dec 20;6(51):443. Unique Identifier : AIDSLINE MED/97235652
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1996 Dec 20;6(51):451-2. Unique Identifier : AIDSLINE MED/97235654
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Mar 28;7(13):117-8. Unique Identifier : AIDSLINE MED/97272869
Notification of patients exposed to a doctor infected with HIV.: Commun Dis Rep CDR Wkly. 1997 Feb 28;7(9):75. Unique Identifier : AIDSLINE MED/97231751
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Feb 28;7(9):83-4. Unique Identifier : AIDSLINE MED/97231753
Respiratory tract cryptosporidiosis in immunosuppressed rat is associated with an epithelial metaplasia.: Parasite. 1995 Mar;2(1):85-7. Unique Identifier : AIDSLINE MED/97283526; Roussel F; Lemeteil D; Favennec L; Tayot J; Ballet JJ; Brasseur P; Laboratoires d'Histologie, Groupe de recherches ERPUR, CHU de Rouen.; Cryptosporidium parvum is an opportunistic protozoa that chronically infects the digestive tract of immunocompromised hosts. Respiratory cryptosporidiosis, which was reported in AIDS patients, is an uncommon feature of mammalian cryptosporidiosis models. In this study, we document the respiratory lesion; observed in a
Human herpesvirus 8 in classic Kaposi sarcoma.: Acta Microbiol Immunol Hung. 1996;43(4):391-5. Unique Identifier : AIDSLINE MED/97206882; Kemeny L; Kiss M; Gyulai R; Kenderessy AS; Adam E; Nagy F; Dobozy A; Department of Dermatology, Albert Szent-Gyorgyi University Medical; School, Szeged, Hungary.; Recent studies suggest the role of a new human herpesvirus (HHV8) in the pathogenesis of different forms of Kaposi sarcoma (KS). In the present work we investigated the presence of HHV8 sequences in KS tumour tissues from patient with classic KS. Since clear evidences point to the role of immune suppression in the dev
Selection of amino acid parameters for Fourier transform-based analysis of proteins.: Comput Appl Biosci. 1996 Dec;12(6):553-62. Unique Identifier : AIDSLINE MED/97173371; Lazovic J; Laboratory for Multidisciplinary Research 180/2, Institute of Nuclear; Sciences Vinca, Belgrade, Yugoslavia. elazovij@ubbg.etf.bg.ac.yu; Fourier analysis of the parametric profile of a sequence for the detection and localization of the structural motifs that are characteristic for biologically related proteins has been proposed. In order to select parameters that are most appropriate for this analysis, the informational capacity of 226 physicochemical,
Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus.: Immunity. 1997 Apr;6(4):401-10. Unique Identifier : AIDSLINE MED/97278842; Fukui Y; Ishimoto T; Utsuyama M; Gyotoku T; Koga T; Nakao K; Hirokawa K; Katsuki M; Sasazuki T; Department of Genetics, Medical Institute of Bioregulation, Kyushu; University, Fukuoka, Japan.; The central event in thymic selection of T cells bearing alpha beta TCRs is their interaction with self-peptides bound to self-MHC molecules. With the use of transgenic mouse lines expressing a single peptide/MHC class II complex, we show that CD4+ T cells with the preferential usage of particular TCR V(alpha)s and V(
Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice.: Immunity. 1997 Apr;6(4):459-67. Unique Identifier : AIDSLINE MED/97278848; Chen YH; Chiu NM; Mandal M; Wang N; Wang CR; Gwen Knapp Center for Lupus and Immunology Research, Department of; Pathology, University of Chicago, Illinois 60637, USA.; The MHC class lb molecule, CD1, has been conserved throughout mammalian evolution. To assess the function of CD1 in lymphocyte development, we generated mice with targeted disruption of the CD1.1 and CD1.2 genes. CD1-deficient mice have normal numbers of CD4+ and CD8+ T cells but marked reduction in NK1.1-bearing T ce
[Thrombosis of the superior longitudinal sinus in patients with AIDS. A review of the literature]: Rev Neurol. 1997 Feb;25(138):247-9. Unique Identifier : AIDSLINE MED/97229300; Pedraza S; Rovira A; Saballs M; Capdevila JA; Unitat de Ressonancia Magnetica, Hospital General Vall d'Hebron,; Barcelona, Espana.; Cerebral dural sinus thrombosis (CSDT) is a rare disease with a high rate of mortality. Until now it has not been well-documented in patients with the acquired immunodeficiency syndrome (AIDS). Prompt diagnosis is essential for initiation of suitable treatment, especially in cases with progressive neurological involve
[Future scenarios of HIV-AIDS: from the "event" disease to diffuse chronicity. From the moral stigma to the central zones of social vulnerability]: Rev Esp Salud Publica. 1997 Jan-Feb;71(1):1-7. Unique Identifier : AIDSLINE MED/97265985; Conde Gutierrez F
HIV-positive males' satisfaction with pharmacy services.: J Am Pharm Assoc (Wash). 1997 Jan-Feb;NS37(1):66-75. Unique Identifier : AIDSLINE MED/97192469; Marshall BC; Cunny KA; Lawson KA; University of Texas at Austin College of Pharmacy, USA.; The objective of this study was to describe the pharmacy needs of a group of males infected with human immunodeficiency virus (HIV) and to determine whether those needs were being met. An anonymous survey was used to determine the perceptions of a group of HIV-positive males. Of 62 usable responses, 53.2% of responden
Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report.: Can J Surg. 1997 Apr;40(2):143-5. Unique Identifier : AIDSLINE MED/97271179; Kibrite A; Zeitouni NC; Cloutier R; Department of Surgery, L'Hotel-Dieu de Quebec, Universite Laval.; Malignant transformation has been described in 30% of cases of giant anorectal condyloma acuminatum. The authors report on a 33-year-old man who was heterosexual and HIV negative and who had a giant anal condyloma. Despite aggressive therapy with multiple fulgurations, interferon alpha and isotretinoin, an invasive sq
HIV/AIDS--the new "great teacher" [editorial]: Can J Public Health. 1997 Jan-Feb;88(1):11-3. Unique Identifier : AIDSLINE MED/97248815; Archibald CP
Determinants of HIV-related high risk behaviours among young offenders: a window of opportunity.: Can J Public Health. 1997 Jan-Feb;88(1):14-7. Unique Identifier : AIDSLINE MED/97248816; Rothon DA; Strathdee SA; Cook D; Cornelisse PG; Health Services, Ministry of the Attorney General of British Columbia,; Victoria.; PURPOSE: To study HIV-associated risk behaviours among young offenders. METHODS: Juveniles aged 12 to 19 years entering correctional facilities in British Columbia volunteered in an unlinked anonymous study. Logistic regression was used to identify factors associated with high-risk sexual behaviours and injection drug
HIV-positive women living in the metropolitan Toronto area: their experiences and perceptions related to HIV testing. The HIV Women's Study Group.: Can J Public Health. 1997 Jan-Feb;88(1):18-22. Unique Identifier : AIDSLINE MED/97248817; Jackson LA; Millson P; Calzavara L; Rachlis A; Rowe C; Strathdee S; Wagner C; Walmsley S; Department of Preventive Medicine and Biostatistics, University of; Toronto.; Forty HIV-positive women from diverse socioeconomic backgrounds were interviewed. Most (90%) did not perceive themselves to be at risk of HIV infection prior to knowing their HIV-positive status. The majority (61%) were tested because they developed symptoms, or because someone with whom they were intimate, or their c
Knowledge and attitude assessment of Quebec daycare workers and parents regarding HIV/AIDS and hepatitis B.: Can J Public Health. 1997 Jan-Feb;88(1):23-6. Unique Identifier : AIDSLINE MED/97248818; Renaud A; Ryan B; Cloutier D; Urbanek A; Haley N; McGill AIDS Centre, Montreal.; ISSUES: Cases of discrimination occur in Quebec daycares towards HIV-positive children as well as HIV-negative children born to seropositive parents. OBJECTIVES: Offer three-hour information sessions on bloodborne diseases, specifically HIV and hepatitis B, universal precautions, as well as legal, ethical and psychoso
Seroprevalence of HIV infection in childbearing women in Nova Scotia.: Can J Public Health. 1997 Jan-Feb;88(1):27-31. Unique Identifier : AIDSLINE MED/97248819; Johnston BL; Haase DA; Armson BA; Lee SH; Manley K; Hazell P; Department of Medicine, Dalhousie University, Halifax, Nova Scotia.; OBJECTIVE: To determine the prevalence of HIV-1 infection in childbearing women in Nova Scotia. DESIGN: An anonymous, unlinked seroprevalence study using leftover cord bloods. The study was done in 2 stages: I-Halifax Co. women delivering between February 1, 1992 and December 31, 1993; II-non-Halifax Co. women deliv
Ring-enhancing brain lesion in a 42-year-old man.: Acad Radiol. 1996 Nov;3(11):968-70. Unique Identifier : AIDSLINE MED/97118306; Tomkovich K; Gooding J; Lee HJ; Department of Radiology, UMDNJ-New Jersey Medical School, University; Hospital, Newark 07103, USA.
Harm reduction: a realistic approach toward injection drug users.: Can Nurse. 1996 Feb;92(2):22-6. Unique Identifier : AIDSLINE MED/96403510; Mattinson K; Hawthorne J; The injection use of illicit drugs is a major mode of HIV transmission in the heterosexual population. Indeed, because HIV is transmitted from injection drug users to their sexual partners and their children, there is widespread acknowledgement that controlling HIV infection in the general community may depend on cont
Neuropathogenesis of simian immunodeficiency virus infection in macaque monkeys.: J Neurovirol. 1997 Feb;3(1):1-9. Unique Identifier : AIDSLINE MED/97218377; Sasseville VG; Lackner AA; Division of Comparative Pathology, Harvard Medical School, New England; Regional Primate Research Center, Southborough, Massachusetts 01772,; USA.; Patients infected with human immunodeficiency virus (HIV) develop immunologic dysfunction and multiorgan inflammatory diseases directly associated with HIV-1 infection. Of these inflammatory diseases, the most devastating to the HIV-infected patient is involvement of the central nervous system (CNS). The pathogenesis
Isolation and long-term culture of primary ocular human immunodeficiency virus type 1 isolates in primary astrocytes.: J Neurovirol. 1997 Feb;3(1):10-5. Unique Identifier : AIDSLINE MED/97218378; Canki M; Potash MJ; Bentsman G; Chao W; Flynn T; Heinemann M; Gelbard H; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital Center,; New York, NY 10019 USA.; Vitreous specimens from 14 HIV-1 infected persons undergoing medically indicated vitrectomy were assayed for the presence of infectious HIV-1 and viral tropism. Human primary fetal astrocytes, adult lymphocytes, or macrophages were exposed to vitreous in culture and and cells were then assayed for HIV-1 DNA by polymer
Transactivation of proenkephalin gene by HTLV-1 tax1 protein in glial cells: involvement of Fos/Jun complex at an AP-1 element in the proenkephalin gene promoter.: J Neurovirol. 1997 Feb;3(1):16-27. Unique Identifier : AIDSLINE MED/97218379; Fu W; Shah SR; Jiang H; Hilt DC; Dave HP; Joshi JB; Laboratories of Molecular Biology/Gene Regulation Research, Veterans; Administration Medical Center, Washington DC 20422, USA.; The human T-cell lymphotropic virus type 1 (HTLV-1), an etiologic agent for adult T-cell leukemia, is strongly associated with tropical spastic paraparesis, a chronic neurological disease. The HTLV-1 genome encodes a protein, tax1, an autoregulator of enhanced viral RNA transcription, that also transactivates/represse
HIV-1 gp120 does not induce Quinolinic acid production by macrophages [letter]: J Neurovirol. 1997 Feb;3(1):86-7. Unique Identifier : AIDSLINE MED/97218388; Pemberton LA; Kerr SJ; Brew BJ
The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1.: Cancer Lett. 1997 Mar 19;114(1-2):187-9. Unique Identifier : AIDSLINE MED/97256447; Steerenberg PA; Garssen J; Dortant PM; van der Vliet H; Geerse E; Verlaan AP; Goettsch WG; Sontag Y; Bueno-de-Mesquita HB; Van Loveren H; National Institute of Public Health and the Environment, Laboratory; for Pathology and Immunobiology, Bilthoven, The Netherlands.; The effects of quercetin (4%) on UVB-induced carcinogenesis and immunosuppression were studied in hairless SKH-1 mice exposed daily to suberythemal UVB for 12/13 and 16/17 weeks. Macroscopic and microscopic examinations showed that quercetin did not affect the onset and growth of UVB-induced non-melanoma skin tumors.
Inhibition of interleukin-2 receptor (CD25) expression induced on T cells from children with acute lymphoblastic leukemia.: Cancer Immunol Immunother. 1997 Mar;44(1):41-7. Unique Identifier : AIDSLINE MED/97265677; Zhang XL; Komada Y; Zhou YW; Chen TX; Sakai H; Azuma E; Ido M; Sakurai M; Department of Pediatrics, Mie University School of Medicine, Japan.; Peripheral blood lymphocytes obtained from children with acute lymphoblastic leukemia (ALL) at onset were studied for the expression of interleukin-2 ( IL-2 ) receptor alpha-chain (CD25) by two-color flow-cytometric analysis. Stimulated with anti-CD3 monoclonal antibody
[Review of 105 cases of isolation of Rhodococcus equi in humans]: Cas Lek Cesk. 1997 Jan 22;136(2):51-3. Unique Identifier : AIDSLINE MED/97272861; Votava M; Skalka B; Hrstkova H; Tejkalova R; Dvorska L; Mikrobiologicky ustav LF MU a FN u sv. Anny, Brno.; BACKGROUND: Rhodococcus equi (formerly Corynebacterium) has been long considered an exclusively zoopathogenic microbe causing mainly granulomatous pneumonias and lung abscesses in young foals. The aim of this paper was to analyse substantial features of R, equi infections hitherto reported in man. METHODS AND RESULTS:
Core structure of gp41 from the HIV envelope glycoprotein.: Cell. 1997 Apr 18;89(2):263-73. Unique Identifier : AIDSLINE MED/97262067; Chan DC; Fass D; Berger JM; Kim PS; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts; 02142, USA.; The envelope glycoprotein of human immunodeficiency virus type 1 HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes. Previous studies identified an alpha-helical domain within gp41 composed
Diagnosis and management of AIDS-related diarrhea.: Can J Gastroenterol. 1996 Nov-Dec;10(7):461-8. Unique Identifier : AIDSLINE MED/97268096; Johanson JF; Department of Medicine, University of Illinois College of Medicine at; Rockford 61107-5078, USA.; The spectrum of illness associated with the acquired immunodeficiency syndrome (AIDS) has been increasing since the initial description in 1981. While virtually all organ systems may be affected, the gastrointestinal tract appears to be a major target. Diarrhea is the most common symptom, affecting up to half of all A
Perforation of the jejunum secondary to AIDS-related gastrointestinal Kaposi's sarcoma.: Can J Gastroenterol. 1997 Jan-Feb;11(1):38-40. Unique Identifier : AIDSLINE MED/97262724; Yoshida EM; Chan NH; Chan-Yan C; Baird RM; Department of Laboratory Medicine and Pathology, St Paul's Hospital,; Vancouver, British Columbia.; Intestinal perforation in human immunodeficiency virus-positive patients due solely to Kaposi s sarcoma (KS) has rarely been described. A homosexual man with acquired immunodeficiency syndrome-related KS who presented with an acute abdomen is presented. He was found to have a jejunal perforation through a small KS les
Small bowel review--Part I.: Can J Gastroenterol. 1997 Jan-Feb;11(1):49-56. Unique Identifier : AIDSLINE MED/97262727; Thomson AB; Jarocka-Cyrta E; Faria J; Wild GE; Department of Medicine, University of Alberta, Edmonton.; alan.thomson@ualberta.ca; The small bowel has undergone intense study. Part I of this two-part review of the small bowel focuses on gastrointestinal peptides; intestinal infections and human immunodeficiency virus; drugs; intestinal growth-mucosal proliferation and differentiation; nucleic acids, nucleotides and nucleosides; vitamins and miner
Comparative study of the expression of cellular proteins in uninfected and HIV infected U937 cells using two dimensional SDS polyacrylamide gel electrophoresis.: Chem Biol Interact. 1997 Mar 14;103(3):179-86. Unique Identifier : AIDSLINE MED/97279576; Lang MC; Cansier C; Rizza P; Jasmin C; Tovey MG; Eid P; Laboratory of Viral Oncology, UPR CNRS, Cedex, France.; The cellular response to HIV infection was determined by analysing the expression of cellular proteins in uninfected and HIV-1 infected U937 cells using two-dimensional protein electrophoresis. HIV infected U937 cells constitute a useful model for the study of the chronic productive infection of cells of the monocyte/
Acute T-cell activation is detectable in unstable angina.: Circulation. 1997 Apr 1;95(7):1806-12. Unique Identifier : AIDSLINE MED/97261213; Neri Serneri GG; Prisco D; Martini F; Gori AM; Brunelli T; Poggesi L; Rostagno C; Gensini GF; Abbate R; Clinica Medica Generale e Cardiologia, Florence, Italy.; BACKGROUND: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. METHODS AND RESULTS: Twenty-nine patients with proven u
Antigen presentation by common variable immunodeficiency (CVID) B cells and monocytes is unimpaired.: Clin Exp Immunol. 1997 Apr;108(1):1-8. Unique Identifier : AIDSLINE MED/97252334; Thon V; Eggenbauer H; Wolf HM; Fischer MB; Litzman J; Lokaj J; Eibl MM; Institute of Immunology, University of Vienna, Austria.; CVID is a primary immunodeficiency syndrome comprising a heterogeneous group of patients with hypogammaglobulinaemia and defective formation of specific antibodies. Previous studies demonstrated defective T cell responsiveness to antigen in a major subgroup of patients. In the present study we investigated the capacit
Corticosteroids restore the balance between locally produced Th1 and Th2 cytokines and immunoglobulin isotypes to normal in sarcoid lung.: Clin Exp Immunol. 1997 Apr;108(1):105-13. Unique Identifier : AIDSLINE MED/97252349; Milburn HJ; Poulter LW; Dilmec A; Cochrane GM; Kemeny DM; Department of Thoracic Medicine and Allergy, UMDS, Guy's Hospital,; London, UK.; In this study, we have investigated the balance between Th1- and Th2-like activity in the lungs in sarcoidosis and have determined the effect of corticosteroid treatment on this. Twenty-one patients with acute untreated sarcoidosis were investigated by bronchoalveolar lavage (BAL) and compared with 11 normal volunteer
Role of IL-15 in HIV-1-associated hypergammaglobulinaemia.: Clin Exp Immunol. 1997 Apr;108(1):14-8. Unique Identifier : AIDSLINE MED/97252336; Kacani L; Stoiber H; Dierich MP; Institut fur Hygiene, Leopold-Franzens-Universitat Innsbruck, Austria.; IL-15 is a novel cytokine, produced by monocytes/macrophages, with biological activities similar to IL-2 but with no significant sequence homology. IL-15 also stimulates human B cells to proliferation and immunoglobulin secretion. We measured serum levels of IL-15 in 8
Down-regulatory role of surface CD4 molecules on autoreactive helper T cells during B cell activation.: Clin Exp Immunol. 1997 Apr;108(1):160-6. Unique Identifier : AIDSLINE MED/97252356; Aizawa K; Hamano T; Iwasaki T; Kakishita E; Second Department of Internal Medicine, Hyogo College of Medicine,; Nishinomiya, Japan.; MS202 is an IL-2-dependent Th2 clone reactive to auto-MHC class II antigens as previously reported. It expresses CD4, TCR-alphabeta, Thy 1.2 and H-2k on the cell membrane, as well as CD40 ligand. In order to investigate a functional role of surface CD4 molecules on Th2 cells during B cell activation, we attempted to e
Mycobacterium avium complex infection. Pharmacokinetic and pharmacodynamic considerations that may improve clinical outcomes.: Clin Pharmacokinet. 1997 Feb;32(2):132-44. Unique Identifier : AIDSLINE MED/97221882; Peloquin CA; Infectious Disease Pharmacokinetics Laboratory, National Jewish; Medical and Research Center, Denver, Colorado, USA. peloquinc@njc.prg; Mycobacterium avium complex (MAC) is an infrequent pulmonary pathogen in immunocompetent hosts. In patients with AIDS, MAC causes disseminated infection (DMAC) in up to 50% of those with CD4+ counts less than 100 cells/mm3. A significant portion of the total body burden of MAC is found inside macrophages, and the dist
Dapsone penetrates cerebrospinal fluid during Pneumocystis carinii pneumonia prophylaxis.: Diagn Microbiol Infect Dis. 1996 Feb;24(2):77-9. Unique Identifier : AIDSLINE MED/97012811; Rich JD; Mirochnick M; The Miriam Hospital/Brown University, Providence, Rhode Island, USA.; Dapsone has been proposed as a prophylactic agent for both Pneumocystis carinii pneumonia (PCP) and reactivation cerebral toxoplasmosis. To determine whether dapsone penetrates the central nervous system, cerebrospinal fluid (CSF) and serum samples were drawn from patients taking dapsone for PCP prophylaxis. These sam
A comparison of Cox proportional hazards and artificial neural network models for medical prognosis.: Comput Biol Med. 1997 Jan;27(1):55-65. Unique Identifier : AIDSLINE MED/97207789; Ohno-Machado L; Decision Systems Group, Brigham and Women's Hospital, Harvard Medical; School, Boston, MA 02115, USA.; Modeling survival of populations and establishing prognoses for individual patients are important activities in the practice of medicine. For patients with diseases that may extend for several years, in particular, accurate assessment of survival probabilities is essential. New methods, such as neural networks, have b
Cardiovascular involvement in AIDS.: Curr Probl Cardiol. 1997 Mar;22(3):109-48. Unique Identifier : AIDSLINE MED/97223788; Michaels AD; Lederman RJ; MacGregor JS; Cheitlin MD; University of California San Francisco, Department of Medicine,; California, USA.
Metabolism of the human immunodeficiency virus type 1 reverse transcriptase inhibitor delavirdine in rats.: Drug Metab Dispos. 1997 Feb;25(2):228-42. Unique Identifier : AIDSLINE MED/97180836; Chang M; Sood VK; Wilson GJ; Kloosterman DA; Sanders PE; Hauer MJ; Fagerness PE; Drug Metabolism Research, Pharmacia & Upjohn, Inc., Kalamazoo, MI; 49007, USA.; Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside reverse transcriptase inhibitor currently under development for the treatment of AIDS. The excretion, disposition, and metabolism of delavirdine were investigated in Sprague-Dawley rat
Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.: Drug Metab Dispos. 1997 Feb;25(2):256-66. Unique Identifier : AIDSLINE MED/97180839; Fitzsimmons ME; Collins JM; Laboratory of Clinical Pharmacology, Center for Drug Evaluation and; Research, U.S. Food and Drug Administration, Rockville, MD 20850, USA.; Saquinavir is a HIV protease inhibitor used in the treatment of patients with acquired immunodeficiency syndrome, but its use is limited by low oral bioavailability. The potential of human intestinal tissue to metabolize saquinavir was assessed in 17 different human small-intestinal microsomal preparations. Saquinavir
[Therapy of HIV infection: combination drug therapy effective, immunotherapy still experimental]: Dtsch Med Wochenschr. 1997 Apr 11;122(15):A32. Unique Identifier : AIDSLINE MED/97279551
Radiologic features of Rhodococcus equi pneumonia in AIDS.: Eur J Radiol. 1997 Jan;24(1):66-70. Unique Identifier : AIDSLINE MED/97209211; Muntaner L; Leyes M; Payeras A; Herrera M; Gutierrez A; Department of Radiology, Son Dureta University Hospital, Palma de; Mallorca, Spain.; This report outlines the radiological features observed in three cases of Rhodococcus equi (R. equi) pneumonia in AIDS (acquired immunodeficiency syndrome) and reviews another 45 radiological reports published of this emerging opportunistic pneumonia in Human Immunodeficiency Virus (HIV) infected patients. The clinica
Lack of HTLV-II infection in newborns born from HIV-1 infected mothers in southern Italy [letter]: Eur J Epidemiol. 1997 Jan;13(1):121-2. Unique Identifier : AIDSLINE MED/97216592; Chironna M; Quarto M; Barbuti S; In order to evaluate the presence of HTLV-II infection in a cohort of newborns born from HIV-1 infected mothers, a retrospective study was conducted on 80 newborns. Only 1 birth serum sample (1.25%) was found seropositive for HTLV-II by Western Blot suggesting a transplacental transmission of anti-HTLV-II antibodies.
High levels of the DNA-binding activity of E2F in adult T-cell leukemia and human T-cell leukemia virus type I-infected cells: possible enhancement of DNA-binding of E2F by the human T-cell leukemia virus I transactivating protein, Tax.: Eur J Haematol. 1997 Feb;58(2):114-20. Unique Identifier : AIDSLINE MED/97265687; Mori N; First Department of Internal Medicine, University of Occupational and; Environmental Health, School of Medicine, Kitakyushu, Japan.; Transcription factor E2F binds to cellular promoters of certain growth- and cell cycle-controlling genes and forms distinct heteromeric complexes with other nuclear proteins. It has therefore been proposed that E2F is involved in cellular proliferation control. Human T-cell leukemia virus type I HTLV-I) is an etiologi
Thiostrepton binds to malarial plastid rRNA.: FEBS Lett. 1997 Apr 7;406(1-2):123-5. Unique Identifier : AIDSLINE MED/97263485; Clough B; Strath M; Preiser P; Denny P; Wilson IR; National Institute for Medical Research, Mill Hill, London, UK.; Binding of the thiazolyl peptide antibiotic thiostrepton to the GTPase domain of 23S rRNA involves a few crucial nucleotides, notably A1067 (E. coli). Small RNA transcripts were prepared corresponding to the GTPase domain of the plastid 23S rRNA and the two forms of cytosolic 28S rRNAs found in the human malaria paras
Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.: FEBS Lett. 1997 Apr 7;406(1-2):191-5. Unique Identifier : AIDSLINE MED/97263501; Papandreou MJ; Fenouillet E; CNRS, UMR 6560, IFR Jean Roche, Faculte de Medecine Nord, Marseille,; France.; Using a CD4-binding assay to assess the conformation of the human immunodeficiency virus envelope glycoprotein (CHO+ Env), we studied the effect of treatment with various glycosidases on the stability of Env in denaturing environments and in biological media: cleavage from Env of either high-mannose-type glycans HMT-
The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells.: Biochem Soc Trans. 1997 Feb;25(1):126S. Unique Identifier : AIDSLINE MED/97209849; Ryan MS; Griffin F; Mahon B; Mills KH; Department of Biology, St Patrick's College, Maynooth, Co. Kildare,; Ireland.
Colonic histoplasmosis in AIDS: unusual endoscopic findings in two cases.: Gastrointest Endosc. 1997 Feb;45(2):199-204. Unique Identifier : AIDSLINE MED/97193423; Halline AG; Maldonado-Lutomirsky M; Ryoo JW; Pau A; Pursell K; Department of Medicine, University of Illinois at Chicago, USA.
Suppression of actively induced experimental autoimmune uveoretinitis by CD4+ T cells.: Graefes Arch Clin Exp Ophthalmol. 1997 Feb;235(2):97-102. Unique Identifier : AIDSLINE MED/97205924; Uchio E; Kijima M; Ishioka M; Tanaka S; Ohno S; Department of Ophthalmology, Yokohama City University School of; Medicine, Japan.; BACKGROUND: Helper/inducer T cells that exert an inhibitory effect on disease induction have been recently found in many experimental models. In order to clarify the mechanisms of spontaneous remission of experimental autoimmune uveoretinitis EAU), we investigated the inhibitory effect and the phenotype of the post-re
Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection.: Hum Pathol. 1997 Apr;28(4):434-42. Unique Identifier : AIDSLINE MED/97258772; Cool CD; Kennedy D; Voelkel NF; Tuder RM; Department of Pathology, University of Colorado Health Sciences; Center, Denver 80262, USA.; Patients with primary pulmonary hypertension develop vascular lesions characterized by proliferated blood channels, the so-called plexiform lesions. These lesions are often associated with concentric intimal obliteration of pulmonary vessels. We report that the lungs of three patients with scleroderma-associated pulmo
Idiopathic perniosis and its mimics: a clinical and histological study of 38 cases.: Hum Pathol. 1997 Apr;28(4):478-84. Unique Identifier : AIDSLINE MED/97258778; Crowson AN; Magro CM; Department of Laboratories, Misericordia General Hospital, Winnipeg,; Manitoba, Canada.; Perniosis is a term applied to cold-induced painful or pruritic erythematous or violaceous acral papular or nodular lesions. We examined 39 skin biopsies from 38 patients who presented with acral purpuric lesions, suggesting a diagnosis of perniosis clinically or pathologically. The presence of a systemic or extracuta
The role of peptide specificity in MHC class I-restricted allogeneic responses.: Immunol Rev. 1996 Dec;154:45-58. Unique Identifier : AIDSLINE MED/97187410; Frelinger JA; McMillan M; Department of Microbiology and Immunology, University of North; Carolina, Chapel Hill 27599-7290, USA.
Down-regulation of Listeria monocytogenes-specific Th1 cytokine response by treatment of mice with goat antibody to mouse IgD.: Immunobiology. 1996;196(4):449-62. Unique Identifier : AIDSLINE MED/97215019; Song F; Matsuzaki G; Nomoto K; Department of Immunology, Kyushu University, Fukuoka, Japan.; Injection of goat anti-mouse IgD antibody (G alpha M IgD) to mice has been shown to induce polyclonal IgG1 and IgE production by B cells and IL-4 production by goat Ig-specific T cells. Surface IgD crosslinking also activates function of B cells as antigen presenting cells. Although the G alpha M IgD treatment is a we
Markers of type D retroviruses in children with Burkitt's-type lymphoma.: Immunol Lett. 1996 Nov;53(2-3):101-4. Unique Identifier : AIDSLINE MED/97177469; Kzhyshkowska JG; Kiselev AV; Gordina GA; Kurmashow VI; Portjanko NM; Ostashkin AS; Ilyin KV; Cancer Virus Immunology Laboratory, Blokhin Cancer Research Center of; RAMS, Moscow, Russia.; Antibodies to gag-coded proteins of type D retroviruses have been detected in children with lymphadenopathy [1]. We tested 41 HIV noninfected children with lymphoproliferative diseases (27 cases of Burkitt s-type lymphoma, six cases of Hodgkin s disease, four cases of T-cell lymphoma, three cases of lymphoblastic lymp
CD8+ cells in HIV infection produce macrophage inflammatory protein-1 alpha and RANTES: a comparative study in long-term survivors and progressor patients.: Immunol Lett. 1996 Nov;53(2-3):105-8. Unique Identifier : AIDSLINE MED/97177470; Zanussi S; D'Andrea M; Simonelli C; Battiston V; Tirelli U; De Paoli P; Microbiology-Immunology-Virology Division, Centro di Riferimento; Oncologico, Aviano, Italy.; Evidence suggests that CD8+ lymphocytes are involved in the control of Human Immunodeficiency virus type 1 (HIV-1) infection by the release of HIV-suppressive factors. The human chemokines RANTES and the macrophage inflammatory protein 1 alpha (MIP-1 alpha) have been identified to be potent inhibitors of HIV in vitro.
Are T cells from healthy heart really only passengers? Characterization of cardiac tissue T cells.: Immunol Lett. 1996 Nov;53(2-3):63-7. Unique Identifier : AIDSLINE MED/97177464; Holzinger C; Zuckermann A; Reinwald C; Imhof M; Schollhammer A; Kramer G; Wolner E; Steiner G; Dept. of Cardiac Surgery, ao Kh St. Polten, Austria.; Numerous studies have dealt with occurrence of dendritic cells in various nonlymphoid organs such as kidney, liver or heart, whereas lymphocyte patterns in these organs have not been analyzed in detail. In the present study, leukocytes were quantified as cells/mm2 in the perivascular, interstitial and parenchymal tiss
Screening for HIV seropositive blood - a critical evaluation.: Indian J Pathol Microbiol. 1995 Apr;38(2):163-8. Unique Identifier : AIDSLINE MED/97078178; Verma A; Pandey J; Khurana SK; Garg M; Talib VH; Department of Laboratory Medicine and Blood Transfusion, Safdarjang; Hospital, New Delhi.; HIV screening of all donated blood is mandatory in India . The program instituted has many inherent lacunac like arbitrary identification of centres, absence of a guardian quality control program, criterion for test kit selection and absence of standard guidelines. This study was und
Perception about AIDS among residents of a Calcutta slum.: Indian J Public Health. 1996 Jan-Mar;40(1):4-9. Unique Identifier : AIDSLINE MED/97246347; Poddar AK; Poddar DS; Mandal RN; Dept. of Health education, A.I.I.H & P.H. Calcutta.; A study was carried out in a slum area of South Calcutta to assess the impact of the current mass education programme against AIDS. Two hundred and six residents, mainly of lower middle class, aged 18-60 years of both sexes were selected at random. They were interviewed to know their perception and sources of informat
Acquired resistance to Cryptococcus neoformans in adult mice vaccinated as newborns.: Infect Immun. 1997 May;65(5):1688-94. Unique Identifier : AIDSLINE MED/97270465; Aguirre KM; Garvy BA; Johnson LL; Trudeau Institute, Inc., Saranac Lake, New York 12983, USA.; aguirre@northnet.org; Although Cryptococcus neoformans causes serious infections in AIDS patients, cryptococcosis in immunologically immature infants, as in immunocompetent adults, is rare. To investigate the resistance of neonates to C. neoformans and to determine whether they could be efficiently vaccinated as neonates against challenge
Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis.: Infect Immun. 1997 May;65(5):1742-7. Unique Identifier : AIDSLINE MED/97270473; Mahanty S; Ravichandran M; Raman U; Jayaraman K; Kumaraswami V; Nutman TB; Laboratory of Parasitic Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.; We investigated the mechanisms by which interleukin-10 (IL-10) regulates antigen-specific hyporesponsiveness in asymptomatic microfilaremic (MF) individuals. Peripheral blood mononuclear cells from MF individuals (n = 11) were stimulated in vitro with Brugia malayi antigen (BMA) or mycobacterial purified protein deriv
Growth within macrophages increases the efficiency of Mycobacterium avium in invading other macrophages by a complement receptor-independent pathway.: Infect Immun. 1997 May;65(5):1916-25. Unique Identifier : AIDSLINE MED/97270497; Bermudez LE; Parker A; Goodman JR; Kuzell Institute of Arthritis and Infectious Diseases, California; Pacific Medical Center Research Institute, San Francisco 94115, USA.; Infections caused by organisms of the Mycobacterium avium complex occur in approximately 50 to 60% of patients with AIDS. M. avium is an intracellular pathogen that survives and multiplies within mononuclear phagocytes. In this study, we investigated the uptake of M. avium grown within macrophages (intracellular growt
[Therapeutic strategies against HIV: status in 1994 and future prospectives]: Internist (Berl). 1994 Jul;35(7 Suppl):1-24. Unique Identifier : AIDSLINE MED/97277698
[Therapy using virus-resistant immunoglobulins. First on the prevention front: immunoglobulins]: Internist (Berl). 1995 Oct;36(10 Suppl):1-4. Unique Identifier : AIDSLINE MED/97277704
[Individualization of HIV-therapy]: Internist (Berl). 1995 Jul;36(7 Suppl [individu]):1-4. Unique Identifier : AIDSLINE MED/97277700
McIver v. Krischer.: Issues Law Med. 1997 Spring;12(4):385-9. Unique Identifier : AIDSLINE MED/97269550
Observations on the possible origin of Mycoplasma fermentans incognitus strain based on antibiotic sensitivity tests.: J Antimicrob Chemother. 1997 Jan;39(1):25-30. Unique Identifier : AIDSLINE MED/97196935; Hannan PC; Mycoplasma Experience Ltd, Reigate, Surrey, UK.; Mycoplasma fermentans (incognitus strain), isolated during transfection studies in NIH/3T3 cells with DNA extracted from Kaposi s sarcoma tissue from a patient suffering from AIDS, showed high levels of resistance to numerous aminoglycoside antibiotics (MICs > 250 to > 500 mg/L) and in this respect matched the aminogl
Receptor-mediated endocytosis of CC-chemokines.: J Biol Chem. 1997 Apr 11;272(15):9617-20. Unique Identifier : AIDSLINE MED/97248501; Solari R; Offord RE; Remy S; Aubry JP; Wells TN; Whitehorn E; Oung T; Proudfoot AE; Cell Biology Unit, Glaxo Wellcome Medicines Research Centre, Gunnels; Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.; RCES4402@ggr.co.uk; Chemokines are chemotactic proteins which play a central role in immune and inflammatory responses. Chemokine receptors are members of the seven transmembrane G-protein coupled family and have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells. To study chemokine en
Inhibition of activator protein 1 activity and neoplastic transformation by aspirin.: J Biol Chem. 1997 Apr 11;272(15):9962-70. Unique Identifier : AIDSLINE MED/97248550; Dong Z; Huang C; Brown RE; Ma WY; The Hormel Institute, University of Minnesota, Austin, Minnesota; 55912, USA.zgdong@wolf.co.net; Aspirin, along with its analgesic-antipyretic uses, is now also being considered for prevention of cardiovascular disease, cancer, and treatment of human immunodeficiency virus infection. Although many of aspirin s pharmacological actions are related to its ability to inhibit prostaglandin biosynthesis, some of its be
Early levels of CD4, neopterin, and beta 2-microglobulin indicate future disease progression.: J Clin Immunol. 1997 Jan;17(1):43-52. Unique Identifier : AIDSLINE MED/97202258; Shi M; Taylor JM; Fahey JL; Hoover DR; Munoz A; Kingsley LA; Department of Biostatistics, UCLA School of Public Health, Los; Angeles, California 90095, USA.; Reduced CD4 T cell level and increased serum neopterin and beta 2-microglobulin levels, which reflect immunological activation and dysregulation, are three important markers of HIV disease. The aim in this study is to delineate more clearly the relation of activation to future CD4 values and disease progression. By an
'Mom, I have something to tell you'--disclosing HIV infection.: J Adv Nurs. 1997 Jan;25(1):139-43. Unique Identifier : AIDSLINE MED/97157743; Katz A; University of Manitoba, Winnipeg, Canada.; This paper explores the experience of disclosing HIV infection to family members. Information was obtained from secondary analysis of interviews conducted with 10 HIV-positive men and women. Learning that one is HIV-positive is a traumatic event, and disclosing this to family members can be difficult. Findings from th
A critical review of the literature on sharps injuries: epidemiology, management of exposures and prevention.: J Adv Nurs. 1997 Jan;25(1):144-54. Unique Identifier : AIDSLINE MED/97157744; Hanrahan A; Reutter L; Capital Health Authority, Edmonton, Alberta, Canada.; This article reviews the literature related to the epidemiology, prevention and management of sharps injuries in health care workers, particularly nurses, and the subsequent risk of harm. The studies are reviewed chronologically, beginning with the efforts to reduce sharps injuries by changing behaviours, followed by
Sexual health promotion and nursing.: J Adv Nurs. 1997 Jan;25(1):170-7. Unique Identifier : AIDSLINE MED/97157747; Irwin R; HIV & Sexual Health Team, Chippenham, England.; The HIV epidemic provides continued impetus for effective sexual health promotion. Sexual health promotion in nursing practice has traditionally been equated to prevention at primary, secondary and tertiary levels. Increasing demands on practitioners to address the psycho-social aspects of sexual health, together with
[Ophthalmologic manifestations observed in a pediatric HIV-seropositive population]: J Fr Ophtalmol. 1997;20(1):49-60. Unique Identifier : AIDSLINE MED/97254046; Girard B; Prevost-Moravia G; Courpotin C; Lasfargues G; Service d'Ophtalmologie, Hopital Robert Ballanger, Aulnay-sous-Bois.; PURPOSE: HIV positive children underwent ophthalmologic examination to evaluate prospectively the incidence, and type of ocular involvement in pediatric AIDS. METHOD: Two ophthalmologists examined the children during their pediatric examination, for two years. When possible, a retinography was performed. RESULTS: Amon
Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis.: J Hepatol. 1997 Jan;26(1):1-5. Unique Identifier : AIDSLINE MED/97206017; Soto B; Sanchez-Quijano A; Rodrigo L; del Olmo JA; Garcia-Bengoechea M; Hernandez-Quero J; Rey C; Abad MA; Rodriguez M; Sales Gilabert M; Gonzalez F; Miron P; Caruz A; Relimpio F; Torronteras R; Leal M; Lissen E; Viral Hepatitis and AIDS Study Group, Virgen del Rocio University; Hospital, Seville, Spain.; BACKGROUND/AIMS: To investigate the possible role of HIV infection in the natural history of chronic parenterally-acquired hepatitis C. METHODS: A multicenter cross-sectional study was performed in 547 patients with chronic parenterally-acquired hepatitis C with or without HIV infection (116 HIV-positive and 431 HIV-n
Obstetric factors and mother-to-infant transmission of HIV-1.: Infect Dis Clin North Am. 1997 Mar;11(1):109-18. Unique Identifier : AIDSLINE MED/97220626; Zorrilla CD; Department of Obstetrics and Gynecology, University of Puerto Rico; School of Medicine, San Juan, USA.; Mother-to-infant HIV transmission has been reported to occur during pregnancy (in utero), at delivery, or postpartum (breast feeding). There are a multiplicity of variables or cofactors that may influence such transmission. Among the obstetric factors reported to be more strikingly associated with mother-to-infant tra
Pneumonia and tuberculosis in pregnancy.: Infect Dis Clin North Am. 1997 Mar;11(1):119-33. Unique Identifier : AIDSLINE MED/97220627; Riley L; Department of Obstetrics and Gynecology, Massachusetts General; Hospital, Boston, USA.; Antepartum pneumonia requires prompt evaluation and empiric antimicrobial therapy. The choice of antimicrobial therapy depends on maternal risk factors, symptoms, and clinical presentation. Although laboratory studies such as culture and serology should be obtained, they may not always yield a specific etiologic agent
Immunocytochemical and flow cytofluorimetric detection of intracellular IL-4, IL-5 and IFN-gamma: applications using blood- and airway-derived cells.: J Immunol Methods. 1997 Apr 11;203(1):89-101. Unique Identifier : AIDSLINE MED/97279601; Krouwels FH; Nocker RE; Snoek M; Lutter R; van der Zee JS; Weller FR; Jansen HM; Out TA; Department of Pulmonology, University of Amsterdam, Netherlands.; We have compared an immunocytochemical and a flow cytofluorimetric method to detect intracellular IFN-gamma, IL-4 and IL-5 in T-cell clones, peripheral blood mononuclear cells PBMC) and bronchoalveolar lavage fluid (BALF) cells. Intracellular bound cytokine-specific antibodies were visualized either with amino-ethyl c
Enhanced expression of T-cell activation and natural killer cell antigens indicates systemic anti-tumor response in early primary cutaneous T-cell lymphoma.: J Invest Dermatol. 1997 May;108(5):743-7. Unique Identifier : AIDSLINE MED/97275332; Asadullah K; Friedrich M; Docke WD; Jahn S; Volk HD; Sterry W; Department of Dermatology, Medical School Charite, Humboldt; UniversityBerlin, Germany.; Indolent, primary cutaneous T-cell lymphomas (CTCL) are characterized by hyper-proliferation of malignant T-helper cells in the skin with a favorable prognosis in the early stages. Cytotoxic T cells (CTLs) are believed to be of major importance for tumor surveillance, but there is not yet sufficient evidence for a sys
Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants.: J Exp Med. 1997 Apr 7;185(7):1153-61. Unique Identifier : AIDSLINE MED/97258608; Pikora CA; Sullivan JL; Panicali D; Luzuriaga K; Department of Pediatrics, University of Massachusetts Medical Center,; Worcester 01605, USA.; High frequencies of cytotoxic T lymphocyte precursors (CTLp) recognizing HIV-1 laboratory strain gene products have been detected in adults within weeks of primary infection. In contrast, HIV-1-specific CTLp are uncommonly detected in infants younger than 6 mo. To address the hypothesis that the use of target cells ex
Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity.: J Exp Med. 1997 Apr 7;185(7):1203-10. Unique Identifier : AIDSLINE MED/97258613; Yamamoto S; Takeda Y; Yamamoto M; Kurazono H; Imaoka K; Yamamoto M; Fujihashi K; Noda M; Kiyono H; McGhee JR; Immunobiology Vaccine Center and Department of Microbiology,; University of Alabama at Birmingham, 35294, USA.; Cholera toxin (CT), the most commonly used mucosal adjuvant in experimental animals, is unsuitable for humans because of potent diarrhea-inducing properties. We have constructed two CT-A subunit mutants, e.g., serine-->phenylalanine at position 61 S61F), and glutamic acid-->lysine at 112 (E112K) by site-directed mutag
The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of major histocompatibility complex (MHC) class I molecules.: J Exp Med. 1997 Apr 7;185(7):1295-305. Unique Identifier : AIDSLINE MED/97258622; Kerkau T; Bacik I; Bennink JR; Yewdell JW; Hunig T; Schimpl A; Schubert U; Institute of Virology and Immunobiology, University of Wurzburg,; Germany.; The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a small integral membrane phosphoprotein with two established functions: degradation of the viral coreceptor CD4 in the endoplasmic reticulum (ER) and augmentation of virus particle release from the plasma membrane of HIV-1-infected cells. We show here t
Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins.: J Exp Med. 1997 Apr 7;185(7):1381-6. Unique Identifier : AIDSLINE MED/97258630; Palmer LD; Weng N; Levine BL; June CH; Lane HC; Hodes RJ; Experimental Immunology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; To address the possible role of replicative senescence in human immunodeficiency virus (HIV) infection, telomere length, telomerase activity, and in vitro replicative capacity were assessed in peripheral blood T cells from HIV+ and HIV- donors. Genetic and age-specific effects on these parameters were controlled by st
Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation.: J Exp Med. 1997 Apr 21;185(8):1423-33. Unique Identifier : AIDSLINE MED/97272078; Goulder PJ; Sewell AK; Lalloo DG; Price DA; Whelan JA; Evans J; Taylor GP; Luzzi G; Giangrande P; Phillips RE; McMichael AJ; Nuffield Department of Medicine, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, United Kingdom.; Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes CTL) to a steady-state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune cont
Normal lymphocyte development but delayed humoral immune response in CD81-null mice.: J Exp Med. 1997 Apr 21;185(8):1505-10. Unique Identifier : AIDSLINE MED/97272087; Maecker HT; Levy S; Department of Medicine and Oncology, Stanford University Medical; Center, California 94305, USA.; CD81 is a cell surface molecule expressed on many cell types and associated with the CD19/CD21/Leu13 signal-transducing complex on B cells. A recent report implies that CD81 expression on thymic stromal cells is important in the maturation of thymocytes from CD4-CD8- to CD4+CD8+. However, we have produced CD81-null mi
Perceptions of social support of African Americans with acquired immunodeficiency syndrome.: J Natl Black Nurses Assoc. 1994 Spring-Summer;7(1):36-49. Unique Identifier : AIDSLINE MED/97274434; Hudson AL; Morris RI; Visiting Nursing Association of San Diego County, California, USA.; Using the grounded theory methodology with symbolic interactionism as the theoretical framework, this study explores the perceptions of support systems that exist for African Americans with AIDS. A convenience sample of five African Americans with AIDS was interviewed and the data analyzed using constant comparative a
African American men: the ideal AIDS program.: J Natl Black Nurses Assoc. 1994 Spring-Summer;7(1):60-7. Unique Identifier : AIDSLINE MED/97274436; Dancy BL; University of Illinois, College of Nursing, Chicago, USA.; Because designing programs based on an understanding of the target population s perceptions, expectations, and experiences is not only beneficial but feasible, a convenience sample of 17 African American men who have sex with men attended one of four focus groups to identify the needs of AIDS clients and what constitu
Anti-HIV antibody in saliva: an assessment of the role of the components of saliva, testing methodologies and collection systems.: J Oral Pathol Med. 1996 Mar;25(3):104-7. Unique Identifier : AIDSLINE MED/97013303; Lamey PJ; Nolan A; Follett EA; Coote I; MacFarlane TW; Kennedy DH; Connell A; Parry JV; The Queen's University of Belfast, N.Ireland.; The various components of saliva, namely mixed saliva, parotid saliva, submandibular saliva, crevicular fluid and minor (labial) gland secretions, were collected from 63 known HIV antibody seropositive patients. A commercial test system, Wellcozyme HIV 1+2, and an antibody capture ELISA (GACELISA), were compared for s
Relationship of circulating CD4+ T-lymphocytes and p24 antigenemia to the risk of developing AIDS in HIV-infected subjects with oral hairy leukoplakia.: J Oral Pathol Med. 1996 Mar;25(3):108-11. Unique Identifier : AIDSLINE MED/97013304; Ravina A; Ficarra G; Chiodo M; Mazzetti M; Romagnani S; Division of Allergy and Clinical Immunology, Polyclinic of Careggi,; Florence, Italy.; To investigate the relationship of circulating CD4+ T-lymphocytes and p24 antigenemia to the development of AIDS in HIV-infected subjects with hairy leukoplakia (HL), we have followed over eight years 173 HIV-positive patients, all asymptomatic at the start of the study, and compared those who developed HL (n=55) to t
Greenspan lesion is a better term than oral "hairly" leukoplakia [letter]: J Oral Pathol Med. 1996 Mar;25(3):144. Unique Identifier : AIDSLINE MED/97013311; van der Waal I
HIV and associated infections.: J R Coll Physicians Lond. 1997 Jan-Feb;31(1):100-2. Unique Identifier : AIDSLINE MED/97197120; Cybulska B; Department of Genitourinary Medicine, St. Thomas's Hospital, London.; Infection with human immunodeficiency virus (HIV), which leads to the acquired human immunodeficiency syndrome (AIDS), presents with a number of opportunistic infections whose management remains a major concern. Understanding their pathogenesis and interactions with the HIV, and applying this knowledge to diagnostic a
[Progressive multifocal leukoencephalopathy. Study of the demyelination by magnetization transfer]: J Radiol. 1997 Feb;78(2):131-4. Unique Identifier : AIDSLINE MED/97267838; Armand JP; Dousset V; Franconi JM; Huot P; Mieze S; Lacoste D; Letenneur L; Caille JM; Servie de Neuroradiologie, CHU Pellegrin, Bordeaux.; PURPOSE: magnetization transfer imaging (MT) has been used to study the degree of demyelination in progressive multifocal leukoencephalopathy (PML). MATERIAL AND METHOD: two groups were studied: a group of 10 HIV + patients with clinical, MR features, biological and/or biopsy proven PML, and a group of 11 normal volun
Arthritis associated with HIV infection in Zimbabwe.: J Rheumatol. 1996 Mar;23(3):506-11. Unique Identifier : AIDSLINE MED/96429843; Stein CM; Davis P; Division of Rheumatology, Vanderbilt University School of Medicine,; Nashville, TN 37232-2681, USA.; OBJECTIVE: To document the clinical and immunogenetic features of arthritis associated with heterosexually acquired human immunodeficiency virus (HIV) infection. METHODS: All patients were assessed by a rheumatologist and standard laboratory tests were performed. RESULTS: There were 3 common clinical presentations. (1
Arylamide inhibitors of HIV-1 integrase.: J Med Chem. 1997 Apr 11;40(8):1186-94. Unique Identifier : AIDSLINE MED/97265355; Zhao H; Neamati N; Mazumder A; Sunder S; Pommier Y; Burke TR Jr; Laboratory of Medicinal Chemistry, Division of Basic Sciences,; National Cancer Institute, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Based on data derived from a large number of HIV-1 integrase inhibitors, similar structural features can be observed, which consist of two aryl units separated by a central linker. For many inhibitors fitting this pattern, at least one aryl ring also requires ortho bis-hydroxylation for significant inhibitory potency.
Kwashiorkor and HIV: new questions.: J Trop Pediatr. 1997 Feb;43(1):50-1. Unique Identifier : AIDSLINE MED/97233927; Beau JP; Imboua-Coulibaly L; ORSTOM, Abidjan, Cote d'Ivoire.
Objective evaluation of two markers of HIV-1 infection (p24 antigen concentration and CD4+ cell counts) by a self organizing neural network.: Med Inf (Lond). 1996 Jul-Sep;21(3):215-28. Unique Identifier : AIDSLINE MED/97216715; Giacomini M; Ruggiero C; Maillard M; Lillo FB; Varnier OE; DIST, Department of Communications Computer and System Sciences,; University of Genova, Italy.; The aim of the present work is to obtain groups of patients with similar profiles of p24 antigen concentration and of CD4+ cell counts. These two markers were chosen because their evaluation represents a significant step in the clinical follow up of HIV-1 infected subjects. The detection methods for p24 antigen concen
Vertical transmission of HIV-2 [letter]: Lancet. 1997 Jan 18;349(9046):177-8. Unique Identifier : AIDSLINE MED/97265641; Cavaco-Silva P; Taveira NC; Lourenco MH; Santos Ferreira MO; Daniels RS
African HIV-1 subtype C and rate of progression among Ethiopian immigrants in Israel [letter]: Lancet. 1997 Jan 18;349(9046):180-1. Unique Identifier : AIDSLINE MED/97265645; Galai N; Kalinkovich A; Burstein R; Vlahov D; Bentwich Z
Attachment of Haemophilus ducreyi to human foreskin fibroblasts involves LOS and fibronectin.: Microb Pathog. 1997 Jan;22(1):39-46. Unique Identifier : AIDSLINE MED/97184992; Alfa MJ; DeGagne P; Department of Medical Microbiology, St. Boniface General Hospital,; University of Manitoba, Winnipeg, Canada.; Haemophilus ducreyi is the causative agent of the genital ulcer disease Chancroid. Chancroid has been shown to increase the risk of heterosexual transmission of HIV. Little is known regarding the attachment or localization of this organism to human cells in either the dermal or epidermal layer. In this study the attac
Does the mechanism of protection from falciparum malaria by red cell genetic disorders involve a switch to a balanced TH1/TH2 cytokine production mode?: Med Hypotheses. 1997 Jan;48(1):11-7. Unique Identifier : AIDSLINE MED/97202464; Bayoumi RA; Biochemistry Department, Faculty of Medicine and Health Sciences,; United Arab Emirates University, Al-Ain, United Arab Emirates.; The mechanism of protection from falciparum malaria by red cell genetic disorders still remains controversial. Decreased survival of parasites in variant red cells has previously been proposed. However, in vitro experiments were not conclusive and do not seem sufficient to explain the substantial degree of in vivo pro
Promotion of interleukin-2 activity as a strategy for rejuvenating' geriatric immune function.: Med Hypotheses. 1997 Jan;48(1):47-54. Unique Identifier : AIDSLINE MED/97202470; McCarty MF; Nutrition 21, San Diego, CA 92109, USA.; The age-related decline in immune capacities is largely attributable to a decrease in the ability of activated T lymphocytes to achieve efficient clonal expansion. This in turn reflects a decrease in the expression of both interleukin-2 and its receptor. Nutritional/hormonal measures which up-regulate such expression
Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP).: MMWR Morb Mortal Wkly Rep. 1997 Apr 25;46(RR-9):1-25. Unique Identifier : AIDSLINE MED/97287866; These recommendations update information concerning the vaccine and antiviral agents available for controlling influenza during the 1997-98 influenza season (superseding MMWR 1996;45[No. RR-5]:1-24). The principal changes include information about a) the influenza virus strains included in the trivalent vaccine for 19
Contraceptive practices before and after an intervention promoting condom use to prevent HIV infection and other sexually transmitted diseases among women--selected U.S. sites, 1993-1995.: MMWR Morb Mortal Wkly Rep. 1997 May 2;46(17):373-7. Unique Identifier : AIDSLINE MED/97286487; Because heterosexual contact is the most common mode of human immunodeficiency virus (HIV) transmission among women, development of effective strategies to reduce sexually transmitted HIV infection is critical. In addition, because most women at risk for HIV infection are reproductive aged (14-44 years), effective use
[Idiopathic CD4(+)-T-lymphocytopenia]: Ned Tijdschr Geneeskd. 1997 Feb 8;141(6):298-301. Unique Identifier : AIDSLINE MED/97212117; van de Ven MJ; Lenders JW; Baas AA; Holdrinet AC; van der Meer JW; Academisch Ziekenhuis, afd. Inwendige Geneeskunde, Nijmegen.; Three patients, two men aged 27 and 33 years and one woman aged 31 years, developed several opportunistic infections without presence of HIV infection. Patient A died after suffering Candida stomatitis, extrapulmonary Mycobacterium avium infection, cytomegalovirus infection and Asp
Metabolite abnormalities in progressive multifocal leukoencephalopathy by proton magnetic resonance spectroscopy.: Neurology. 1997 Apr;48(4):836-45. Unique Identifier : AIDSLINE MED/97263993; Chang L; Ernst T; Tornatore C; Aronow H; Melchor R; Walot I; Singer E; Cornford M; Department of Neurology, UCLA School of Medicine, Harbor-UCLA Medical; Center, Torrance, CA 90509, USA.; OBJECTIVE: To evaluate progressive multifocal leukoencephalopathy PML) lesions using proton magnetic resonance spectroscopy (1H MRS). DESIGN: CSF polymerase chain reaction (PCR) detection for JC viral (JCV) DNA; MRI and localized 1H MRS in the PML lesions, normal-appearing contralateral brain regions (CONTRA), and in
Anergic disseminated toxoplasmosis in a patient with AIDS. Case report.: Minerva Med. 1997 Mar;88(3):101-4. Unique Identifier : AIDSLINE MED/97259204; Mastroianni A; Coronado O; Scarani P; Manfredi R; Chiodo F; Dipartimento di Medicina Clinica Specialistica, Policlinico San; Orsola, Universita degli Studi, Bologna.; In recent years, Toxoplasma gondii has emerged as an important life-threatening opportunistic pathogen in compromised hosts. Toxoplasma gondii is considered the opportunistic agent most frequently causing severe encephalitis in AIDS. Less common manifestations of active toxoplasma infection include extracerebral and d
[Azithromycin combined with pyrimethamine in the treatment of neurotoxoplasmosis, in an AIDS patient]: Minerva Med. 1997 Mar;88(3):117-9. Unique Identifier : AIDSLINE MED/97259207; Trotta M; Sterrantino G; Milo D; Dionisio D; Leoncini F; Unita Operativa di Malattie Infettive, Azienda Ospedaliera, Careggi,; Firenze.; We report one case of successful treatment of cerebral toxoplasmosis in acquired immunodeficiency syndrome (AIDS) with azithromycin combined with pyrimethamine. Toxoplasmic encephalitis had been diagnosed on the basis of multiple lesions exhibiting ring like contrast enhancement on double contrast Computed Tomographic
Picture resembling hemicentral retinal vein occlusion in the acquired immunodeficiency syndrome: is it related to cytomegalovirus?: Ophthalmologica. 1996;210(2):108-11. Unique Identifier : AIDSLINE MED/97012649; Mansour AM; Li H; Segal EI; Department of Ophthalmology, University of Texas Medical Branche,; Galveston, USA.; Three HIV-seropositive subjects presented with diffuse inferior retinal hemorrhages. The first patient had an inferior hemicentral vein occlusion with subsequent development of an inferior cytomegalovirus retinitis. Two other patients had an inferior hemorrhagic cytomegalovirus r
[Tsukamurella infections. Review of the literature apropos of a case]: Pathol Biol (Paris). 1997 Jan;45(1):60-5. Unique Identifier : AIDSLINE MED/97252309; Rey D; Fraisse P; Riegel P; Piemont Y; Lang JM; Centre d'Informations et de Soins de l'Immunodeficience Humaine,; Clinique Medicale A, Hopitaux Universitaires, Strasbourg, France.; The genus Tsukamurella belongs to the family Nocardiaceae, and is an environmental saprophyte. The type species is Tsukamurella paurometabola. Its microbiological identification and differentiation from the other species containing mycolic acids can be difficult. There has been a few cases of human infections reported
Anticipatory guidance: developing a healthy sexuality.: Pediatr Ann. 1997 Feb;26(2 Suppl):S142-5. Unique Identifier : AIDSLINE MED/97194017; Wright K; Adolescent HIV Program, Children's Hospital of Michigan, USA.
New uses for older antibiotics. The 'rediscovery' of four beneficial and cost-effective antimicrobials.: Postgrad Med. 1997 Apr;101(4):68-70, 73-4, 79-80 passim. Unique Identifier : AIDSLINE MED/97271254; Cunha BA; Infectious disease division, Winthrop-University Hospital, Mineola,; New York 11501, USA.; Because of its intracellular mechanism of activity, excellent safety profile, and low cost, doxycycline is one of the most extensively used antibiotics in the world, and its use will increase as new applications are found. One of its most important uses is in treatment of bacterial community-acquired pneumonias, but i
[Why does cerebral toxoplasmosis still occur in patients with immunodeficiency virus infection? (letter)]: Presse Med. 1997 Mar 29;26(10):464. Unique Identifier : AIDSLINE MED/97283235; Bachmeyer C; Salmon D; Blanche P; Dhote R; Sicard D; Sereni D
[Tuberculosis: epidemiological, bacteriological and therapeutic changes (editorial)]: Presse Med. 1997 Apr 5;26(11):500-1. Unique Identifier : AIDSLINE MED/97283245; Pariente R; The regular decline in the incidence of tuberculosis up to 1985 left us with the hope that the disease might one day be totally irradicated. But from 1985 on the number of cases has remained unchanged at about 8000 new cases per year in France . Resistant strains have also been iden
[Generalized Mycobacterium avium complex infections in patients with HIV infection: a decreasing incidence (letter)]: Presse Med. 1997 Apr 5;26(11):513. Unique Identifier : AIDSLINE MED/97283250; Cambau E; Jouan M; Jarlier V; Bricaire F
[Stavudine: current information]: Presse Med. 1997 Apr 5;26(11):514-5. Unique Identifier : AIDSLINE MED/97283251; Saimot AG; Hopital Bichat-Claude Bernard, Paris.
[Cryptosporidium infection: value of a protease inhibitor letter)]: Presse Med. 1997 Mar 22;26(9):416. Unique Identifier : AIDSLINE MED/97283266; Contamin B; Boibieux A; Gerard-Boncompain M; Bouhour D; Girault V; Biron F; Peyramond D
Renal changes in patients with acquired immunodeficiency syndrome: a post-mortem study on an unselected population in northwestern Italy.: Mod Pathol. 1997 Mar;10(3):159-67. Unique Identifier : AIDSLINE MED/97225348; Monga G; Mazzucco G; Boldorini R; Cristina S; Giacalone A; Fortunato M; Motta M; Campobasso O; Dipartimento di Scienze Biomediche e Oncologia Umana, Sezione di; Anatomia Patologica Torino, Italy.; The renal pathologic features of 120 consecutively autopsied patients affected by acquired immunodeficiency syndrome was investigated by light microscopic analysis. Variously associated renal changes were found in 82 patients (68.3%). Glomerular changes were present in 25. The following diagnoses were made: mesangial
Detection of human herpes virus type 8 DNA sequences as a valuable aid in the differential diagnosis of Kaposi's sarcoma.: Mod Pathol. 1997 Mar;10(3):182-7. Unique Identifier : AIDSLINE MED/97225351; Maiorana A; Luppi M; Barozzi P; Collina G; Fano RA; Torelli G; Istituto di Anatomia Patologica, University of Modena, Italy.; The occurrence of human herpes virus type 8 (HHV-8) DNA sequences was evaluated by polymerase chain reaction in 36 cases of cutaneous Kaposi s sarcoma (KS) (classic and associated with the acquired immunodeficiency syndrome) and in 88 pathologic entities that can histologically mimic KS, such as reactive and neoplasti
Histiocytic necrotizing lymphadenitis (Kikuchi's disease): in situ end-labeling, immunohistochemical, and serologic evidence supporting cytotoxic lymphocyte-mediated apoptotic cell death.: Mod Pathol. 1997 Mar;10(3):231-41. Unique Identifier : AIDSLINE MED/97225358; Felgar RE; Furth EE; Wasik MA; Gluckman SJ; Salhany KE; Department of Pathology and Laboratory Medicine, University of; Pennsylvania Medical Center, Philadelphia, USA.; Histiocytic necrotizing lymphadenitis (Kikuchi s disease) is a benign, self-limited disorder that is sometimes confused with malignant lymphoma. Kikuchi s disease is characterized by collections of histiocytes and lymphocytes surrounding areas of necrosis containing fragments of karyorrhectic nuclear debris. Polymorph
Evolutionary pattern of intra-host pathogen antigenic drift: effect of cross-reactivity in immune response.: Philos Trans R Soc Lond B Biol Sci. 1997 Jan 29;352(1349):11-20. Unique Identifier : AIDSLINE MED/97204141; Haraguchi Y; Sasaki A; Department of Biology, Faculty of Science, Kyushu University, Fukuoka,; Japan.; Several viruses are known to change their surface antigen types after infecting a host, thereby escaping the immune defence and ensuring persistent infection. In this paper, we theoretically study the pattern of intra-host micro-evolution of pathogen antigen variants under the antigen specific immune response. We assu
Content analysis of gay male and lesbian personal advertisements.: Psychol Rep. 1996 Apr;78(2):371-4. Unique Identifier : AIDSLINE MED/97012689; Hatala MN; Prehodka J; Division of Social Science, Northeast Missouri State University,; Kirksville, Missouri 63501, USA; SS08%NEMOMUS.bitnet@ACADEMIC.NEMOSTATE.EDU.; 396 randomly selected gay and lesbian personal advertisements were analyzed for content. Analysis supported the hypotheses that the 198 men are more interested in sexuality and physical attractiveness, while the 198 women are more concerned with the personality characteristics of prospective partners.
Assessing variability of HIV transmission attitudes and behaviors at an urban northeastern university.: Psychol Rep. 1996 Apr;78(2):375-83. Unique Identifier : AIDSLINE MED/97012690; Donnelly J; Donnelly M; Kittleson MJ; Procaccino AT Jr; Fogarty KJ; Duncan DF; McClerren BL; Heskett Center, Wichita State University, KS 6726O-OO16, USA; DonnellylO@AOL.COM.; Teenagers in the United States are one of the populations whose HIV infection rates are increasing most rapidly. This study was designed to measure college students knowledge of HIV transmission methods using Kittleson and Venglarcik s HIV Transmission Survey. Participants (N= 167) we
Subclinical depressive symptoms in HIV are related to avoidance coping responses: a comparison with end-stage renal failure and breast cancer.: Psychol Rep. 1996 Apr;78(2):483-8. Unique Identifier : AIDSLINE MED/97012706; Fukunishi I; Hosaka T; Negishi M; Moriya H; Hayashi M; Matsumoto T; Tokyo Institute of Psychiatry, Japan.; We examined the relationship between coping responses and mood states among three samples of patients with human immunodeficiency virus (HIV) infection (n=26), end-stage renal failure (n=98), and breast cancer (n= 60). Avoidance scores differed significantly across the groups, being highest in those with HIV infection
The face of AIDS: Effects of physical attractiveness and target gender on inferred mode of HIV infection.: Psychol Rep. 1996 Apr;78(2):595-8. Unique Identifier : AIDSLINE MED/97012719; Boehm L; Wambaugh M; Riney T; Kunzelman C; Department of Psychology, Thomas More College, Crestview Hills, KY; 41017, USA boehml@thomasmore.edu.; We examined the effects of physical attractiveness on the assumed mode of HIV acquisition. 176 students read a description of an HIV-positive target whose photograph was placed above the description. A 2 (target gender) by 2 (attractive or unattractive target) factorial design was used. Unattractive targets were perce
[Histoplasmosis in immunodepressed patients: study of 18 cases seen in Uberlandia, MG]: Rev Soc Bras Med Trop. 1997 Mar-Apr;30(2):119-24. Unique Identifier : AIDSLINE MED/97261153; Borges AS; Ferreira MS; Silvestre MT; Nishioka S de A; Rocha A; Centro de Ciencias Biomedicas da Universidade Federal de Uberlandia,; MG, Brasil.; The diagnosis of histoplasmosis was made by isolation of Histoplasma capsulatum from cerebrospinal fluid (CSF), blood and bone marrow or by histopathologic (biopsy or post mortem) examination. The mean age of the patients was 35.8 years; 13 patients were male (72.2%). The disease was disseminated, with the following d
"Have you seen this?" Protease inhibitor toxicity.: Toxicol Pathol. 1997 Jan-Feb;25(1):113-5. Unique Identifier : AIDSLINE MED/97215506; Alden C; Sanderson T; Morris D; Ivett J; Baron D; Snook S
Antiretroviral therapy: a guide to the most important trials.: Schweiz Med Wochenschr. 1997 Mar 15;127(11):436-43. Unique Identifier : AIDSLINE MED/97253476; Rutschmann O; Hirschel B; Division of Infectious Diseases, Hopital Cantonal Universitaire de; Geneve.; AIDS and HIV infection have stimulated an unprecedented amount of research. In this review we have selected a few publications illustrating key issues. Viral load monitoring is useful because short-term changes in viremia, caused by antiretroviral treatment, predict long-term outcome. Combination therapy with
Group brands AIDS trials unethical [news]: Science. 1997 Apr 25;276(5312):519. Unique Identifier : AIDSLINE MED/97284367
AIDS trials ethics questioned [news; comment] [see comments]: Science. 1997 Apr 25;276(5312):520-3. Unique Identifier : AIDSLINE MED/97284368; Cohen J
Current problems and the future of antiretroviral drug trials [see comments]: Science. 1997 Apr 25;276(5312):548-50. Unique Identifier : AIDSLINE MED/97284381; Lange JM; National AIDS Therapy Evaluation Center (NATEC), Academic Medical; Center, University of Amsterdam, Amsterdam, The Netherlands.; j.lange@amc.uva.nl
Control of inflammation, cytokine expression, and germinal center formation by BCL-6.: Science. 1997 Apr 25;276(5312):589-92. Unique Identifier : AIDSLINE MED/97274217; Dent AL; Shaffer AL; Yu X; Allman D; Staudt LM; Metabolism Branch, National Cancer Institute, National Institutes of; Health, Bethesda, MD 20892, USA.; The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognitio
[Blood donation: a constantly evolving concept (editorial; comment)]: Sangre (Barc). 1996 Dec;41(6):413-6. Unique Identifier : AIDSLINE MED/97213561; Gimeno JJ; Bunuel C
[Morphological changes in the bone marrow of patients with HIV infection (letter; comment)]: Sangre (Barc). 1996 Dec;41(6):481-3. Unique Identifier : AIDSLINE MED/97213570; Rodriguez JN
Prolonged murine cardiac allograft acceptance: characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody.: Transplantation. 1997 Apr 27;63(8):1109-17. Unique Identifier : AIDSLINE MED/97278895; Orosz CG; Wakely E; Sedmak DD; Bergese SD; VanBuskirk AM; The Ohio State University College of Medicine, Department of Surgery,; Columbus 43210, USA.; We have treated DBA/2-->C57BL/6 murine cardiac allograft recipients with anti-CD4 monoclonal antibody or with gallium nitrate to promote long-term (>60 days) allograft survival. Within this period, all grafts developed histologic evidence of ongoing vascular and parenchymal tissue remodeling, including interstitial fi
CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of major histocompatibility complex-deficient" skin grafts.: Transplantation. 1997 Apr 27;63(8):1123-33. Unique Identifier : AIDSLINE MED/97278897; Lee RS; Grusby MJ; Laufer TM; Colvin R; Glimcher LH; Auchincloss H Jr; Tranplantation Unit, General Surgical Services, Harvard Medical; School, Massachusetts General Hospital, Boston 02114, USA.; BACKGROUND: Skin grafts from mice that are deficient in the expression of both class I and class II major histocompatibility complex (MHC) antigens are rejected rapidly by normal recipients. METHODS: To determine the mechanism of this rejection, MHC-deficient skin grafts were placed on recipients with different degree
Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo.: Transplantation. 1997 Apr 27;63(8):1171-8. Unique Identifier : AIDSLINE MED/97278904; Smyth MJ; Kershaw MH; Trapani JA; Cellular Cytotoxicity Laboratory, The Austin Research Institute,; Heidelberg, Victoria, Australia.; As little is known about the molecular mechanisms responsible for lymphocyte-mediated rejection of xenografts, we have studied the relative contribution of perforin and Fas pathways in cytotoxic lymphocytes generated in mice transplanted with human cell lines. Responder lymphocytes generated in immunocompetent mice di
Evidence of infection with feline immunodeficiency virus among Danish cats between 1970 and 1974.: Vet Rec. 1997 Jan 25;140(4):99-100. Unique Identifier : AIDSLINE MED/97185170; Flagstad A; Jensen AL; Jarrett O; Small Animal Hospital, Royal Veterinary and Agricultural University,; Frederiksberg, Denmark.
New therapies for cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome.: West J Med. 1997 Feb;166(2):138-9. Unique Identifier : AIDSLINE MED/97263236; Cunningham ET Jr
Cytotoxic T cell induction with ratchet peptide libraries.: Vaccine. 1996 Dec;14(17-18):1664-70. Unique Identifier : AIDSLINE MED/97185156; Kuebler PJ; Nixon DF; United Biomedical, Inc., Hauppauge, NY 11788, USA.; Immunization with synthetic peptides are used to induce cytotoxic T cell (CTL) responses in vivo. However, CTL peptide vaccines require the use of multiple peptides to overcome genetic diversity associated with MHC restriction, and prior epitope identification from the chosen protein template. We describe here a metho
New scientific developments towards an AIDS vaccine: report on a workshop organized by EU programme EVA entitled Novel approaches to AIDS vaccine development held at the Institut Pasteur, Paris. 16-17 November 1995.: Vaccine. 1996 Dec;14(17-18):1712-7. Unique Identifier : AIDSLINE MED/97185163; Oxford JS; Jeffs SA; Department of Medical Microbiology, St Bartholemews, London, UK.
The spectrum of mucosa-associated lymphoid tissue lesions in pediatric patients infected with HIV: A clinicopathologic study of six cases.: Am J Clin Pathol. 1997 May;107(5):592-600. Unique Identifier : AIDSLINE MED/97274125; Joshi VV; Gagnon GA; Chadwick EG; Berard CW; McClain KL; Leach CT; Jenson HB; Murphy SB; Department of Pathology and Laboratory Medicine, East Carolina; University School of Medicine, Greenville, North Carolina, USA.; Mucosa-associated lymphoid tissue (MALT) lesions in nonimmunocompromised individuals include reactive lymphoid proliferations and both low- and high-grade lymphoid neoplasms. These lesions occur at extranodal mucosal sites, such as the gastrointestinal tract, bronchus, salivary gland, and other locations. The spectrum
Barrier methods in the operating room: surgical habits die hard.: Ann R Coll Surg Engl. 1997 Mar;79(2):121-3. Unique Identifier : AIDSLINE MED/97280931; Karagkevrekis B; Warwick D; Freeman B; Orthopaedic Department, Bristol Royal Infirmary.; Transmission of viral infection, such as human immunodeficiency virus or hepatitis B and C, is a concern for both surgeon and patient. Published guidelines advise the regular use of barrier preventive measures in order to minimise the occupational exposure of surgeons. A telephone survey was conducted of 92 orthopaedi
Human immunodeficiency virus and the brain.: Annu Rev Neurosci. 1996;19:1-26. Unique Identifier : AIDSLINE MED/96430308; Glass JD; Johnson RT; Department of Neurology, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21287, USA.; Human immunodeficiency virus (HIV) infects the nervous system in the majority of patients, causing a variety of neurological syndromes throughout the course of the disease. This review focuses on the effects of HIV in the central nervous system, with an emphasis on HIV-associated demen
[The effect of HIV infection on high incidence of heart diseases in Kinshasa (Zaire). Echocardiographic study]: Ann Cardiol Angeiol (Paris). 1997 Feb;46(2):81-7. Unique Identifier : AIDSLINE MED/97283569; Longo-Mbenza B; Tonduangu K; Kintonki Vita E; Seghers KV; Service de Cardiologie, Universite de Kinshasa, Zare.; Invasion of the heart by HIV has become a clinical problem over the last decade. The objective of the present study was to systematically detect the excess HIV-related cardiac lesions in Kinshasa by performing echocardiography. The study population consisted of 166 HIV-infected patients and 166 HIV-seronegative patien
Nonrandom features of the human immunoglobulin variable region gene repertoire expressed in response to HIV-1.: Appl Biochem Biotechnol. 1996 Oct-Nov;61(1-2):149-55. Unique Identifier : AIDSLINE MED/97254970; Zouali M; Departement d'Immunologie, Institut Pasteur, Paris, France.; Characterization of the immune response toward HIV is important for understanding the basic mechanisms of the disease and may give essential information for development of an anti-HIV vaccine. Paradoxically, although HIV infection is associated with a strong antibody response to structural and nonstructural HIV protei
HIV-I protease. Cloning, expression, and purification.: Appl Biochem Biotechnol. 1996 Oct-Nov;61(1-2):97-107. Unique Identifier : AIDSLINE MED/97254966; Dergousova NI; Amerik AYu; Volynskaya AM; Rumsh LD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian; Academy of Sciences, Moscow, Russia. nd@enzyme.siobc.ras.ru; A new method for obtaining HIV-I protease was suggested. Fusion proteins composed of the N-terminal fragment of human gamma-interferon and HIV-I protease connected with (Asp)4Lys protein I) or Asp-Pro (protein II) linkers were expressed in Escherichia coli cells. The fusion proteins were produced as insoluble inclusio
Response to influenza virus vaccination in vertical HIV infection.: Arch Dis Child. 1997 Mar;76(3):215-8. Unique Identifier : AIDSLINE MED/97280953; Lyall EG; Charlett A; Watkins P; Zambon M; Department of Paediatric Infectious Diseases, Imperial College School; of Medicine at St Mary's, London.; OBJECTIVE: To assess the antibody response to influenza vaccine of children vertically infected with HIV. DESIGN: Prospective study in HIV infected children vaccinated during the winter of 1994-5. SETTING: Family HIV clinic at St Mary s Hospital, Paddington. SUBJECTS: 25 children, aged 1-11 years, vertically infected
Kala-azar comes to New York.: Arch Intern Med. 1997 Apr 28;157(8):921-3. Unique Identifier : AIDSLINE MED/97275783; Parkas V; Godwin J; Murray HW; Division of Infectious Diseases, Memorial Sloan-Kettering Cancer; Center, New York, NY, USA.; Visceral leishmaniasis (kala-azar) is a disseminated protozoal infection that occurs in areas of the world other than North America. In endemic regions, kala-azar is also an opportunistic infection associated with the acquired immunodeficiency syndrome. We report a case of acquired immunodeficiency syndrome-associated
Syphilis and AIDS.: Arch Immunol Ther Exp (Warsz). 1996;44(5-6):329-33. Unique Identifier : AIDSLINE MED/97169600; Podwinska J; Institute of Immunology and Experimental Therapy, Polish Academy of; Sciences, Wroclaw, Poland.; Evidence is shown that syphilis has become a major public health problem again. From 1988 to 1995 the permanently growing number of new cases of syphilis in the world was observed. The majority of the syphilitic cases in the patients are difficult for curing. The central nervous system is often involved in early syphi
Does hepatitis B virus or hepatitis C virus infection influence CD4 count in HIV-positive individuals?: Arch Immunol Ther Exp (Warsz). 1996;44(5-6):335-43. Unique Identifier : AIDSLINE MED/97169601; Smiatacz T; Zielinska W; Clinic for Infectious Diseases, Medical Academy, Gdansk, Poland.; Objective of the study was to determine whether there is any influence of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on CD4 count decline rate in HIV-infected individuals. Retrospective analysis of consecutive CD4 counts was conducted in 72 HIV-infected untreated individuals (including 57 intravenous
Long-term assessment of interferon responses in the HIV+ and AIDS patients.: Arch Immunol Ther Exp (Warsz). 1996;44(5-6):345-52. Unique Identifier : AIDSLINE MED/97169602; Piasecki E; Knysz B; Inglot M; Simon K; Gladysz A; Laboratory of Virology, Institute of Immunology and Experimental; Therapy, Polish Academy of Sciences, Wroclaw, Poland.; Impairment of interferon (IFN) system in human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome AIDS) became a basis for searching IFN responses to monitor the disease progression. For detailed investigations 16 HIV+/AIDS patients with at least 4 successively taken blood samples available
Interferon and tumor necrosis factor production by peripheral blood leukocytes of patients with infectious mononucleosis.: Arch Immunol Ther Exp (Warsz). 1996;44(5-6):353-7. Unique Identifier : AIDSLINE MED/97169603; Kaminska T; Kandefer-Szerszen M; Szuster-Ciesielska A; Rzeszowska G; Markowska H; Modrzewska R; Department of Virology and Immunology, Maria Curie-Sklodowska; University, Lublin, Poland.; Blood samples from 29 patients with infectious mononucleosis (IM) in phases of acute disease and convalescence were obtained. Interferon alpha (IFN-alpha) and tumor necrosis factor alpha TNF-alpha) activity was detected in sera of patients both in: acute and convalescence phase, however when IFN titers were higher in
Phosprenyl: a novel drug with antiviral and immunomodulatory activity.: Arch Immunol Ther Exp (Warsz). 1996;44(5-6):395-400. Unique Identifier : AIDSLINE MED/97169610; Danilov LL; Maltsev SD; Deyeva AV; Narovlyansky AN; Sanin AV; Ozherelkov SV; Pronin AV; Joint-Stock Company Micro-plus, N.F. Gamaleya Research Institute of; Epidemiology and Microbiology, Russian Academy of Medical Sciences,; Moscow, Russia.; A novel antiviral drug with immunomodulatory activity Phosprenyl) is presented. The main active ingredient of the preparation is polyprenyl phosphates. This medicine is highly efficient against a number of viruses, including HIV in vitro, and tick-borne encephalitis and rabies viruses in the experimental models in viv
Autopsy risk and acquisition of human immunodeficiency virus infection: a case report and reappraisal.: Arch Pathol Lab Med. 1997 Jan;121(1):64-6. Unique Identifier : AIDSLINE MED/97265158; Johnson MD; Schaffner W; Atkinson J; Pierce MA; Department of Pathology, Vanderbilt University School of Medicine,; Nashville, Tenn 37232, USA.; Autopsy findings have contributed greatly to our understanding of acquired immunodeficiency syndrome. To our knowledge, documented autopsy-acquired infection with human immunodeficiency virus type 1 has not been reported, suggesting autopsy performance is of limited risk. We present a well-documented case of autopsy-a
Segmental xanthomatosis of the ileocecal valve with anatomic and functional obstruction.: Arch Pathol Lab Med. 1997 Jan;121(1):75-8. Unique Identifier : AIDSLINE MED/97265161; Goodman MD; Department of Pathology, Sinai Hospital of Baltimore, MD 21315, USA.; A case of intestinal obstruction due to segmental xanthomatosis involving the small intestine and colon at the ileocecal valve is described in a patient with acquired immunodeficiency syndrome. Infiltration of the bowel wall with lipid-laden histiocytes is documented and is associated with severe attenuation and disru
Syphilitic uveitis in human immunodeficiency virus-infected patients.: Arch Ophthalmol. 1997 Apr;115(4):469-73. Unique Identifier : AIDSLINE MED/97263882; Shalaby IA; Dunn JP; Semba RD; Jabs DA; Ocular Immunology Service, Wilmer Ophthalmological Institute,; Baltimore, Md, USA.; OBJECTIVE: To document the incidence and clinical features of syphilitic uveitis in patients coinfected with human immunodeficiency virus (HIV). DESIGN: Retrospective chart review. SETTINGS: Single tertiary uveitis referral center. PATIENTS: The charts of HIV-infected patients with uveitis and a reactive fluorescent t
Acquired trichomegaly associated with acquired immunodeficiency syndrome [letter]: Arch Ophthalmol. 1997 Apr;115(4):557-8. Unique Identifier : AIDSLINE MED/97263902; Graham DA; Sires BS
New AsMA HIV policy [news]: Aviat Space Environ Med. 1997 Mar;68(3):279. Unique Identifier : AIDSLINE MED/97209095
Expression of a putative immunosuppressive protein in human tumors and tissues.: Pathobiology. 1996;64(5):233-8. Unique Identifier : AIDSLINE MED/97220843; Turbeville MA; Rhodes JC; Hyams DM; Distler CM; Steele PE; Department of Pathology and Laboratory Medicine, University of; Cincinnati College of Medicine, Ohio 45267-0529, USA.; Tumor-induced immunosuppression by murine retrovirus-induced tumors and nonviral murine and human tumors has been shown to be mediated by the transmembrane (TM) envelope (env) protein p15E. This in vitro activity is inhibitable by anti-(murine)p15E antibodies, implying that a TM-like protein is produced by such tumors
Prediction of murine MHC class I epitopes in a major house dust mite allergen and induction of T1-type CD8+ T cell responses.: Int Immunol. 1997 Feb;9(2):273-80. Unique Identifier : AIDSLINE MED/97192190; Harris SJ; Roth JF; Savage N; Woodrow SA; Hemingway IK; Hoyne GF; Lamb JR; Layton GT; British Biotech Pharmaceuticals Ltd, Oxford, UK.; The group I (Der p 1) allergen of Dermatophagoides pteronyssinus house dust mite, HDM) contains several T helper (Th) epitopes recognized by C57BL/6 mice, with the peptide (111-139) containing a dominant MHC class II-restricted epitope (113-127). Since CD8+ T cells are thought to play a role in the regulation of aller
A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I.: Int Immunol. 1997 Feb;9(2):339-46. Unique Identifier : AIDSLINE MED/97192196; Yamazaki H; Ikeda H; Ishizu A; Nakamaru Y; Sugaya T; Kikuchi K; Yamada S; Wakisaka A; Kasai N; Koike T; Hatanaka M; Yoshiki T; Department of Pathology, Hokkaido University School of Medicine,; Sapporo, Japan.; To investigate the pathogenesis of human T lymphocyte virus type I (HTLV-I)- related diseases, the env-pX gene of HTLV-I was introduced into the germline of inbred Wistar-King-Aptekman-Hokudai rats. A wide spectrum of collagen vascular diseases was evident in the transgenic rats, including chronic destructive arthriti
Mitomycin C dissolved in a reversible thermosetting gel: target tissue concentrations in the rabbit eye.: Br J Ophthalmol. 1997 Jan;81(1):72-5. Unique Identifier : AIDSLINE MED/97281105; Ichien K; Yamamoto T; Kitazawa Y; Oguri A; Ando H; Kondo Y; Department of Ophthalmology, Gifu University School of Medicine,; Japan.; AIMS: To determine whether a new, reversible thermosetting gel enhances mitomycin C transfer to target ocular tissues in the rabbit eye. METHODS: A 0.1 ml solution of mitomycin C containing 0.22 microgram, 2.9 micrograms, or 28 micrograms of the agent dissolved in a reversible thermosetting gel consisting of methylcel
Surgical management of HIV related retinal detachment [editorial; comment]: Br J Ophthalmol. 1997 Mar;81(3):177-8. Unique Identifier : AIDSLINE MED/97281069; Charteris DG
Retinal detachment in AIDS: long-term results after repair with silicone oil [see comments]: Br J Ophthalmol. 1997 Mar;81(3):180-3. Unique Identifier : AIDSLINE MED/97281071; Irvine AR; Lonn L; Schwartz D; Zarbin M; Ballesteros F; Kroll S; Department of Ophthalmology, Beckman Vision Center, University of; California, San Francisco 94143-0730, USA.; AIMS: To study the long-term results of vitrectomy and silicone oil injection in AIDS patients with retinal detachment due to viral retinitis. METHODS: A consecutive series of 83 eyes in 75 AIDS patients who were treated with vitrectomy and silicone oil for retinal detachment due to viral retinitis was studied prospec
Management of varicella zoster virus retinitis in AIDS.: Br J Ophthalmol. 1997 Mar;81(3):189-94. Unique Identifier : AIDSLINE MED/97281073; Moorthy RS; Weinberg DV; Teich SA; Berger BB; Minturn JT; Kumar S; Rao NA; Fowell SM; Loose IA; Jampol LM; Department of Ophthalomology, Northwestern University Medical School,; Chicago, IL 60611, USA.; AIMS/BACKGROUND: Varicella zoster virus retinitis (VZVR) in patients with AIDS, also called progressive outer retinal necrosis (PORN), is a necrotising viral retinitis which has resulted in blindness in most patients. The purposes of this study were to investigate the clinical course and visual outcome, and to determi
Should patients with facial fractures be regarded as high risk for HIV?: Br J Oral Maxillofac Surg. 1997 Feb;35(1):59-63. Unique Identifier : AIDSLINE MED/97195635; Crosher RF; Llewelyn J; MacFarlane A; Department of Maxillofacial Surgery, City Hospital, Edinburgh, UK.; OBJECTIVE: To determine the prevalence of HIV seropositivity in patients with facial fractures in Edinburgh, UK. DESIGN: A prospective study of 100 consecutive patients in 1994. SETTING: Department of Maxillofacial Surgery, City Hospital, Edinburgh, UK. SUBJECTS: 100 patients with facial fractures who were willing to
AIDS knowledge, concerns, and behavioral changes among inner-city high school students.: J Adolesc Health. 1996 May;18(5):325-8. Unique Identifier : AIDSLINE MED/97013779; Sikand A; Fisher M; Friedman SB; Division of Adolescent Medicine, Children's Hospital of Michigan,; Detroit, Michigan 48201, USA.; Knowledge of AIDS, attitudes toward AIDS and condoms, and behavioral changes because of AIDS were studied in 771 students, Grades 9-12 (mean age, 16 years) who completed anonymous questionnaires in gym classes of a New York City high school. Students demonstrated good knowledge of AIDS, with some misconceptions, and s
Specific inhibition of in vitro reverse transcription using antisense oligonucleotides targeted to the TAR regions of HIV-1 and HIV-2.: Biochim Biophys Acta. 1997 Apr 10;1351(3):249-55. Unique Identifier : AIDSLINE MED/97276894; Boulme F; Perala-Heape M; Sarih-Cottin L; Litvak S; Laboratoire Reger, Institut de Biochimie et Genetique Cellulaires du; CNRS, IBGC-CNRS, Bordeaux, France.; Antisense oligonucleotides (ODNs) overlapping the stem-loop structure of the trans-activating responsive (TAR) element at the 5 end of HIV-1 and HIV-2 viral RNAs were tested for their inhibitory effect on cDNA synthesis by HIV-1 and HIV-2 reverse transcriptases (RT). Inhibition of reverse transcription is sequence-sp
Influence of endosome-destabilizing peptides on efficacy of anti-HIV immunotoxins.: Bioconjug Chem. 1997 Jan-Feb;8(1):38-43. Unique Identifier : AIDSLINE MED/97178643; Tolstikov VV; Cole R; Fang H; Pincus SH; Laboratory of Microbial Structure and Function, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious Diseases,; National Institutes of Health, Hamilton, Montana 59840, USA.; The effects on immunotoxin efficacy of fusogenic peptides derived from influenza virus hemagglutinin have been studied. These peptides have an amphipathic nature and change conformation from random at pH 7 to helical at pH 5. Fusogenic peptides are reported to destabilize endosomal membranes, resulting in the release
Validation of the assay method for camphor and menthol in a herbal drug preparation.: J Pharm Biomed Anal. 1996 Dec;15(3):419-22. Unique Identifier : AIDSLINE MED/97109423; Karuza L; Folivarski K; SAPONIA, Chemical, Food and Pharmaceutical Industries, Osijek,; Croatia.
Binding characteristics of KNI-272 to plasma proteins, a new potent tripeptide HIV protease inhibitor.: Biopharm Drug Dispos. 1996 Dec;17(9):739-51. Unique Identifier : AIDSLINE MED/97123278; Kiriyama A; Nishiura T; Ishino M; Yamamoto Y; Ogita I; Kiso Y; Takada K; Department of Pharmaceutics and Pharmacokinetics, Kyoto Pharmaceutical; University, Japan.; The binding characteristics of KNI-272, a potent and selective human immunodeficiency virus (HIV) protease inhibitor, were evaluated in rat and human plasma, and in solutions of human alpha 1-acid glycoprotein (AAG) and human serum albumin (HSA). The unbound fractions (Fu) of KNI-272 were 12.13 and 2.24% in rat and hu
Human immunodeficiency virus (HIV)-resistant CD4+ UT-7 megakaryocytic human cell line becomes highly HIV-1 and HIV-2 susceptible upon CXCR4 transfection: induction of cell differentiation by HIV-1 infection.: Blood. 1997 Apr 15;89(8):2670-8. Unique Identifier : AIDSLINE MED/97261970; Baiocchi M; Olivetta E; Chelucci C; Santarcangelo AC; Bona R; d'Aloja P; Testa U; Komatsu N; Verani P; Federico M; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.; Recent findings have shown that the expression of the seven trans-membrane G-protein-coupled CXCR4 (the receptor for the stromal cell-derived factor [SDF]-1 chemokine) is necessary for the entry of T-lymphotropic human immunodeficiency virus (HIV) strains, acting as a coreceptor of the CD4 molecule. In the human syste
Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients.: Blood. 1997 Apr 15;89(8):2689-700. Unique Identifier : AIDSLINE MED/97261972; Scaradavou A; Woo B; Woloski BM; Cunningham-Rundles S; Ettinger LJ; Aledort LM; Bussel JB; Department of Pediatrics, The New York Hospital-Cornell Medical; Center, New York, NY 10021, USA.; We report the results of intravenous anti-D (WinRho, WinRho SD) therapy in 261 non-splenectomized patients treated at the New York Hospital-Cornell Medical Center over the period from 1987 to 1994. Children (n = 124) and adult patients (n = 137) with classic immune thrombocytopenic purpura (ITP; n = 156) or human immu
Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect.: Blood. 1997 Apr 15;89(8):2842-8. Unique Identifier : AIDSLINE MED/97261989; Taoufik Y; Lantz O; Wallon C; Charles A; Dussaix E; Delfraissy JF; Laboratoire Virus, Neurones et Immunite, Universite Paris-Sud, Le; Kremlin-Bicetre, France.; Interleukin-12 (IL-12), a cytokine with in vitro and in vivo immunomodulatory effects, is produced mostly by activated monocytes and macrophages. To study the effect of human immunodeficiency virus (HIV) infection on IL-12 production, we investigated the expression of IL-12 at mRNA and protein levels by human monocyte
A synthetic CD4-CDR3 peptide analog enhances bone marrow engraftment across major histocompatibility barriers.: Blood. 1997 Apr 15;89(8):2880-90. Unique Identifier : AIDSLINE MED/97261994; Koch U; Korngold R; Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA; 19107, USA.; The efficacy of a synthetic peptide analog mimicking the CDR3-D1 domain of the CD4 molecule was investigated in murine models of allogeneic bone marrow engraftment after transplantation across major histocompatibility complex (MHC) barriers. A single dose of a CD4-CDR3 peptide analog was administered at the time of ma
CD8+ T cells activated during the course of murine acute myelogenous leukemia elicit therapeutic responses to late B7 vaccines after cytoreductive treatment.: Blood. 1997 Apr 15;89(8):2915-24. Unique Identifier : AIDSLINE MED/97261998; Dunussi-Joannopoulos K; Krenger W; Weinstein HJ; Ferrara JL; Croop JM; Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston,; MA 02115, USA.; We have previously shown in a murine acute myelogenous leukemia AML) model that leukemic mice can be cured with a B7 vaccine if immunized early in the disease and that CD8+ T cells are necessary for tumor rejection. However, when B7 vaccine is administered 2 weeks after leukemia inoculation, the effect is only prolong
OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration.: Blood. 1997 Apr 15;89(8):2951-8. Unique Identifier : AIDSLINE MED/97262001; Imura A; Hori T; Imada K; Kawamata S; Tanaka Y; Imamura S; Uchiyama T; Research Center for Immunodeficiency Virus, Kyoto University, Sakyo,; Japan.; We demonstrated previously that OX40 and its ligand, gp34, directly mediate adhesion of activated normal CD4+ T cells, as well as human T-cell leukemia virus type I (HTLV-I)-transformed T cells to vascular endothelial cells. In the present study, we examined expression of OX40 on fresh leukemic cells from patients wit
Risk to surgeons: my experience in surgically treating patients with HIV [editorial]: Surg Today. 1997;27(1):1-2. Unique Identifier : AIDSLINE MED/97187845; Sugimachi K
The Neuman Systems Model: application in a Canadian HIV setting.: Br J Nurs. 1997 Feb 13-26;6(3):163-6. Unique Identifier : AIDSLINE MED/97257648; Mill JE; University of Alberta, Edmonton, Canada.; In healthcare research, education and practice there is evidence of a paradigm shift away from disease and illness towards an emphasis on wellness and health. The Neuman Systems Model (NSM) is a nursing model that has been used in a variety of settings with individuals, families and communities. The focus of this mode
Ozone alters T-helper cell mediated bronchial hyperreactivity and resistance to bacterial infection.: Exp Toxicol Pathol. 1996 Nov;48(6):497-9. Unique Identifier : AIDSLINE MED/97112682; Steerenberg PA; Garssen J; van Bree L; van Loveren H; Laboratory of Pathology and Immunobiology, National Institute of; Public Health and The Environment, Bilthoven, The Netherlands.
Human herpesvirus type-8 (HHV-8) in haematopoietic neoplasia.: Leuk Lymphoma. 1997 Jan;24(3-4):257-66. Unique Identifier : AIDSLINE MED/97206094; Gaidano G; Pastore C; Gloghini A; Volpe G; Capello D; Polito P; Vaccher E; Tirelli U; Saglio G; Carbone A; Department of Medical Sciences, University of Torino, Novara, Italy.; Human herpesvirus type-8 (HHV-8) is a lymphotropic herpesvirus originally identified in Kaposi s sarcoma. Among lymphoproliferative disorders, HHV-8 infection is restricted to body-cavity-based lymphoma (BCBL) and multicentric Castleman s disease (MCD). BCBL are B-cell lymphomas growing in liquid phase in the body cav
HTLV-I/II as a common etiology of myelopathies in Bahia, Brazil.: Braz J Med Biol Res. 1996 Jun;29(6):757-61. Unique Identifier : AIDSLINE MED/97223696; Andrade-Filho AS; Brites C; dos-Santos SR; Harrington Junior W; Reinhardt IC; Freitas FM; Silva MC; Badaro R; Departamento de Medicina, Universidade Federal da Bahia, Salvador, BA,; Brasil.; Infection by human T-cell lymphotrophic virus type I (HTLV-I) is associated with a myelopathy known as tropical spastic paraparesis (TSP). The prevalence of HTLV-I infection was found to be high in a pilot study in Bahia, Brazil . In the present study, among patients with myelopathy
One approach to care for patients infected with human immunodeficiency virus in an academic medical center.: Bull N Y Acad Med. 1996 Winter;73(2):301-13. Unique Identifier : AIDSLINE MED/97137173; Jacobs JL; Damson LC; Rogers DE; Center for Special Studies, New York Hospital/Cornell University; Medical Center, New York 10021, USA.; The human immunodeficiency virus (HIV) epidemic poses unprecedented challenges to the health-care system. Caregivers must contend both with the complicated clinical syndromes associated with HIV infection and with issues that are central to the epidemic, such as discrimination, isolation, poverty, and substance abuse.
[AIDS and pregnancy]: Contracept Fertil Sex. 1997 Mar;25(3):XXV-XXX. Unique Identifier : AIDSLINE MED/97273604; Benos P; Boulot P; Services Gynecologie-Obstetrique Centre Hospitalier, Universitaire A.; De Villeneuve Faculte De Medecine, Universite Montpellier 1.
[Sex behavior of patients attending a free, anonymous HIV screening center in Paris]: Contracept Fertil Sex. 1997 Mar;25(3):242-50. Unique Identifier : AIDSLINE MED/97273599; Aynaud O; People s sexual behavior changes as they acquire knowledge od HIV infection. During a 10-week period (September-November 1994), we analysed the results of interviews conducted prior to free, anonymous tests in the Figuier HIV screening center (CDAG, Paris). Men accounted for 61% of the 1275 attendees, and 62% were age
Respiratory problems in the immune-compromised host.: Pediatr Allergy Immunol. 1996;7(9 Suppl):82-5. Unique Identifier : AIDSLINE MED/97206300; Schauer U; Klinik fur Kinder- und Jugendmedizin, Ruhruniversitat im St. Josef; Hospital, Bochum, Germany.
Liver histopathology in patients with concurrent chronic hepatitis C and HIV infection.: Virchows Arch. 1997 Apr;430(4):271-7. Unique Identifier : AIDSLINE MED/97279625; Bierhoff E; Fischer HP; Willsch E; Rockstroh J; Spengler U; Brackmann HH; Oldenburg J; Department of Pathology, University of Bonn, Germany.; To investigate the influence of human immunodeficiency virus HIV) coinfection on preexisting long-term chronic C hepatitis HCV) 68 liver biopsies from 22 HIV/HCV-coinfected, 13 HIV- and 33 HCV-monoinfected patients and 71 livers obtained at autopsy from 26 HIV/HCV-coinfected and 45 HIV-monoinfected patients were studi
The role of cytotoxic T lymphocytes in the evolution of genetically stable viruses.: Trends Microbiol. 1997 Feb;5(2):64-9. Unique Identifier : AIDSLINE MED/97262648; Khanna R; Burrows SR; Burrows JM; Queensland Institute of Medical Research, Bancroft Centre, Herston,; Australia. rajivk@qmir.edu.an
HIV infection as a risk factor for septic arthritis.: Br J Rheumatol. 1997 Mar;36(3):333-7. Unique Identifier : AIDSLINE MED/97279524; Saraux A; Taelman H; Blanche P; Batungwanayo J; Clerinx J; Kagame A; Kabagabo L; Ladner J; Van de Perre P; Le Goff P; Bogaerts J; Department of Internal Medicine, Centre Hospitalier de Kigali, Rwanda.; We prospectively studied the demographics, the clinical and diagnostic features, the HIV-1 serostatus and the therapeutic response for all new patients with septic arthritis (SA) admitted to the Department of Internal Medicine of the Centre Hospitalier de Kigali, Rwanda , over a 19
Sulphasalazine in the treatment of HIV-related spondyloarthropathy [letter]: Br J Rheumatol. 1997 Mar;36(3):403-4. Unique Identifier : AIDSLINE MED/97279540; Njobvu PD; McGill PE
Pseudomonas aeruginosa bronchopulmonary infection in patients with advanced human immunodeficiency virus disease.: Br J Radiol. 1996 Dec;69(828):1099-103. Unique Identifier : AIDSLINE MED/97281155; Traill ZC; Miller RF; Ali N; Shaw PJ; Department of Radiology, John Radcliffe Hospital, Oxford, UK.; Pseudomonas aeruginosa is increasingly reported as a respiratory pathogen in patients with advanced human immunodeficiency virus HIV) disease. We retrospectively reviewed the chest radiographic appearances of 29 HIV-infected adults with bronchopulmonary infection in whom Pseudomonas aeruginosa was the sole respiratory
CT appearances of intrathoracic Kaposi's sarcoma in patients with AIDS.: Br J Radiol. 1996 Dec;69(828):1104-7. Unique Identifier : AIDSLINE MED/97281156; Traill ZC; Miller RF; Shaw PJ; Department of Radiology, John Radcliffe Hospital, Oxford, UK.; Although there have been many studies of the plain radiographic appearances of intrathoracic Kaposi s sarcoma in patients with the acquired immunodeficiency syndrome, the computed tomography CT) findings are less well established. We performed a retrospective review of the thoracic CT findings of 15 patients with trac
Comparative pharmacokinetic, immunologic and hematologic studies on the anti-HIV-1/2 compounds aconitylated and succinylated HSA.: J Drug Target. 1996;4(2):109-16. Unique Identifier : AIDSLINE MED/97050243; Swart PJ; Beljaars E; Smit C; Pasma A; Schuitemaker H; Meijer DK; Groningen Institute for Drug Studies, University Centre for Pharmacy,; The Netherlands. P.J.Swart@farm.rug.nl; Charge modification by succinylation or cis-aconitylation of the terminal epsilon NH2 functions of the amino acid lysine in human serum albumin, resulted in polyanionic compounds with an anti-HIV-1 activity in the low nanomolar concentration range. After iv injections in rats of the negatively charged albumins NCAs),
Selective depletion of CD8-positive leukocytes does not alter mercuric chloride induced acute renal failure in the rat.: Exp Nephrol. 1997 Jan-Feb;5(1):69-81. Unique Identifier : AIDSLINE MED/97205347; Ghielli M; Verstrepen WA; Dauwe S; Nouwen EJ; De Broe ME; Department of Nephrology-Hypertension, University of Antwerp, Belgium.; The process of injury and regeneration in different models of acute renal failure is accompanied by the transient interstitial accumulation of mononuclear leukocytes. The relationship between these accumulated cells and the onset and progression of the regeneration process resulting in the complete functional and morp
Central nervous system pathology in patients with the Guillain-Barre syndrome.: Brain. 1997 Mar;120 ( Pt 3):451-64. Unique Identifier : AIDSLINE MED/97271106; Maier H; Schmidbauer M; Pfausler B; Schmutzhard E; Budka H; Institute of Neurology, University of Vienna, Austria.; Thirteen autopsy cases of patients with clinical criteria of the Guillain-Barre syndrome were investigated for pathological changes and cellular composition of inflammatory infiltrates in the CNS and PNS. The survival times from the onset of neurological symptoms until death ranged from 1 day to 12 months. In the CNS,
The relationship of sexual abuse and HIV risk behaviors among heterosexual adult female STD patients.: Child Abuse Negl. 1997 Feb;21(2):149-56. Unique Identifier : AIDSLINE MED/97209152; Thompson NJ; Potter JS; Sanderson CA; Maibach EW; Department of Behavioral Sciences and Health Education, Rollins School; of Public Health, Emory University, Atlanta, GA 30322, USA.; Some effects of sexual abuse, for example, heightened sexual activity, are also risk factors for infection with the human immunodeficiency virus (HIV). Moreover, Social Cognitive theory suggests that the reduced self-esteem and increased sexual arousal that can result from abuse might alter self-efficacy for performin
T-cells and macrophages in HIV disease.: Clin Rev Allergy Immunol. 1996-97 Winter;14(4):359-66. Unique Identifier : AIDSLINE MED/97193375; McGrath MS; AIDS Immunobiology Research Laboratory, San Francisco General; Hospital, CA, USA.
B-lymphocytes and autoantibody profiles in HIV disease.: Clin Rev Allergy Immunol. 1996-97 Winter;14(4):367-84. Unique Identifier : AIDSLINE MED/97193376; Ng VL; Department of Laboratory Medicine, University of California San; Francisco, USA.
Rheumatologic manifestations of HIV infections.: Clin Rev Allergy Immunol. 1996-97 Winter;14(4):385-416. Unique Identifier : AIDSLINE MED/97193377; Kaye BR; Stanford University School of Medicine, University of California at; San Francisco, USA.
HIV and psoriasis.: Clin Rev Allergy Immunol. 1996-97 Winter;14(4):417-31. Unique Identifier : AIDSLINE MED/97193378; Badger J; Berger TG; Gambla C; Koo JY; University of California, San Francisco 94143, USA.
Allergic manifestations in AIDS.: Clin Rev Allergy Immunol. 1996-97 Winter;14(4):433-49. Unique Identifier : AIDSLINE MED/97193379; Avila PC; Kishiyama JL; Division of Allergy and Immunology, University of California, San; Francisco 94143-0954, USA.
Adverse reactions to trimethoprim-sulfamethoxazole.: Clin Rev Allergy Immunol. 1996-97 Winter;14(4):451-5. Unique Identifier : AIDSLINE MED/97193380; Lee BL; Department of Medicine, University of California, San Francisco; General Hospital 94110, USA.
Cryptococcal meningitis and primary CNS lymphoma in a patient with acquired immunodeficiency syndrome: a case report.: Chung Hua I Hsueh Tsa Chih (Taipei). 1997 Jan;59(1):50-4. Unique Identifier : AIDSLINE MED/97280514; Wang JH; Hsieh SP; Liu YC; Yen MY; Wang JH; Chen YS; Wann SR; Fann-Jian YL; Department of Medicine, Veterans General Hospital-Kaohsiung, Taiwan,; R.O.C.; This report describes a case of cryptococcal meningitis as the initial manifestation of acquired immunodeficiency syndrome AIDS). During the admission, computed tomography (CT) of brain revealed multiple lesions with ring-enhancement over the cerebellum, frontal and temporal lobes. Autopsy findings showed diffuse cryp
Informed consent needed before HIV testing of pregnant mothers: CMA [news]: Can Med Assoc J. 1997 Apr 15;156(8):1108. Unique Identifier : AIDSLINE MED/97286883
Anger over HIV questions cancels blood clinic at Ottawa university.: Can Med Assoc J. 1997 Apr 15;156(8):1181-3. Unique Identifier : AIDSLINE MED/97286901; Gray C; Ottawa s Carleton University cancelled a February blood-donor clinic after the Red Cross failed to hold sensitivity-training sessions for its volunteers. The sessions were requested after students complained that the organization s screening procedures are insensitive and offend gay students. The Red Cross maintains t
Mycoplasmas: sophisticated, reemerging, and burdened by their notoriety.: Emerg Infect Dis. 1997 Jan-Mar;3(1):21-32. Unique Identifier : AIDSLINE MED/97271515; Baseman JB; Tully JG; Department of Microbiology, University of Texas Health Science Center,; San Antonio 78284-7758, USA. baseman@uthscsa.edu; Mycoplasmas are most unusual self-replicating bacteria, possessing very small genomes, lacking cell wall components, requiring cholesterol for membrane function and growth, using UGA codon for tryptophan, passing through bacterial-retaining filters, and displaying genetic economy that requires a strict dependence on
Cryptosporidiosis: an emerging, highly infectious threat.: Emerg Infect Dis. 1997 Jan-Mar;3(1):51-7. Unique Identifier : AIDSLINE MED/97271518; Guerrant RL; Division of Geographic and International Medicine, University of; Virginia School of Medicine, Charlottesville 22908, USA.; rlg9a@virginia.edu; Cryptosporidium parvum, a leading cause of persistent diarrhea in developing countries, is a major threat to the U.S. water supply. Able to infect with as few as 30 microscopic oocysts, Cryptosporidium is found in untreated surface water, as well as in swimming and wade pools, day-care centers, and hospitals. The orga
Computerized assessment of arithmetic computation skills with MicroCog [letter]: J Int Neuropsychol Soc. 1997 Mar;3(2):199-200; discussion 200. Unique Identifier : AIDSLINE MED/97272016; Devivo K; Rothland J; Price L; Fein G
Deep vein thrombosis as a manifestation of the acquired immunodeficiency syndrome? A case report.: Cent Afr J Med. 1996 Nov;42(11):327-8. Unique Identifier : AIDSLINE MED/97276689; Tanimowo M; University Teaching Hospital, Lusaka, Zambia.; A case report of a patient with idiopathic lower extremity deep vein thrombosis in association with human immunodeficiency virus infection is presented. The possibility of deep vein thrombosis being a manifestation of the acquired immunodeficiency syndrome is therefore highlighted. Palliative measures and low dose int
Women's HIV risk reduction efforts and traditional models of health behavior: a review and critique.: Womens Health. 1997 Spring;3(1):1-30. Unique Identifier : AIDSLINE MED/97257406; Gillespie CC; New York University, Center for Community Research and Action, NY; 10003, USA.; This article reviews the empirical literature on women and HIV prevention and evaluates the predictive utility of prevailing models of health behavior change. The review focuses on three constructs that are central to the health belief model, protection motivation theory, and the theories of reasoned action and planne
Report on the 4th International Symposium of Ocular Inflammation [editorial]: Ocul Immunol Inflamm. 1997 Mar;5(1):1-9. Unique Ident