1997
- Combinatorial libraries, epitope structure and the prediction of protein conformations.
- Immunol Today. 1997 Mar;18(3):108-10. Unique Identifier : AIDSLINE MED/97233778
- Gershoni JM; Stern B; Denisova G; Dept of Cell Research and Immunology, Tel Aviv University, Israel.; gershoni@post.tau.ac.il
- Aqueous solution structure of a hybrid lentiviral Tat peptide and a model of its interaction with HIV-1 TAR RNA.
- J Biomol Struct Dyn. 1996 Feb;13(4):649-60. Unique Identifier : AIDSLINE MED/97063017
- Mujeeb A; Parslow TG; Yuan YC; James TL; Department of Pharmaceutical Chemistry, University of California, San; Francisco 94143-0446, USA.
- Human immunodeficiency virus, type 1, (HIV-1) encodes a transactivating regulatory protein, called Tat, which is required for efficient transcription of the viral genome. Tat acts by binding to a specific RNA stem-loop element, called TAR, on nascent viral transcripts. The specificity of binding is principally determi
- The treatment of antiretroviral-naive subjects with the 3TC/zidovudine combination: a review of North American (NUCA 3001) and European (NUCB 3001) trials.
- AIDS. 1996 Dec;10 Suppl 5:S11-9. Unique Identifier : AIDSLINE MED/97182351
- Eron JJ Jr; University of North Carolina, Chapel Hill 27599-7030, USA.
- OBJECTIVE: The compound (-)-2 ,3 -dideoxy-3 -thiacytidine ( 3TC , lamivudine) is a nucleoside analogue with potent in vitro antiretroviral activity, synergy with zidovudine, activity against zidovudine-resistant isolates and minimal cytotoxicity. In ear
- The role of immunologic and viral markers in predicting clinical outcome in HIV infection.
- AIDS. 1996 Dec;10 Suppl 5:S21-5. Unique Identifier : AIDSLINE MED/97182352
- Graham NM; Johns Hopkins University, Baltimore, Maryland, USA.
- OBJECTIVE: In an ideal world, one clinical marker would explain all the variance in a disease system. In reality, however, this is rarely the case and HIV disease is no exception. This review considers several specific markers that have demonstrated some use in clinical trials and/or epidemiologic studies of antiretro
- Clinical significance of drug resistance in HIV-1 infection.
- AIDS. 1996 Dec;10 Suppl 5:S27-31. Unique Identifier : AIDSLINE MED/97182353
- Kuritzkes DR; Division of Infectious Diseases, University of Colorado Health; Sciences Center, Denver 80262, USA.
- OVERVIEW: The limited duration of clinical benefit from nucleoside analogue therapy for HIV-1 infection may be explained, in part, by the emergence of virus isolates resistant to the drugs used. Additional reasons may include the presence of syncytium-inducing variants of HIV-1, progressive increase in viral load and
- Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase.
- AIDS. 1996 Dec;10 Suppl 5:S3-10. Unique Identifier : AIDSLINE MED/97182350
- Wainberg MA; Hsu M; Gu Z; Borkow G; Parniak MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.
- OBJECTIVE: To measure the extent of HIV resistance to 2 ,3 -dideoxy-3 -thiacytidine ( 3TC , lamivudine) within the context of monotherapy and to assess the presence of the M184V substitution in the case of 3TC-resistant viruses. Whether the success of 3
- [Diagnosis and treatment of facial palsy]
- Neurologia. 1997 Jan;12(1):23-30. Unique Identifier : AIDSLINE MED/97222725
- Noya M; Pardo J; Servicio de Neurologia, Hospital General de Galicia-Clinico; Universitario, Santiago de Compostela.
- The topographic diagnosis of facial nerve lesions is based on the symptoms that accompany paralysis, allowing lesions to be located in the protuberance, pontocerebellar angle, facial channel or trajectory distal to the stylomastoid foramen. Most cases of peripheral facial palsy have no apparent cause (idiopathic, or B
- Using cost-effectiveness/cost-benefit analysis to allocate health resources: a level playing field for prevention?
- Am J Prev Med. 1997 Jan-Feb;13(1):18-25. Unique Identifier : AIDSLINE MED/97189066
- Phillips KA; Hotlgrave DR; Department of General Internal Medicine Institute for Health Policy; Studies, School of Medicine, University of California, San Francisco,; USA.
- INTRODUCTION: Prevention is being promoted as a means to improve health status and to save health care costs. Economic evaluations of prevention (i.e., cost-effectiveness and cost-benefit analyses) indicate that some prevention activities, like many treatments, do not save money, although many are relatively cost-effe
- [Clinical and ultrastructural evaluation of nasal mucociliary function in HIV-positive patients. Preliminary investigation]
- Acta Otorrinolaringol Esp. 1997 Jan-Feb;48(1):27-30. Unique Identifier : AIDSLINE MED/97245402
- Armengot M; Climent B; Carda C; Ortega E; Basterra J; Servicio de ORL, Facultad de Medicina, Hospital General Universitario; de Valencia.
- Nasal mucociliary transport was studied in 33 HIV-positive patients with different stages of infection. Ciliary ultrastructure was studied in 8 of these cases. At the time of study, 24 patients had respiratory infections. Disturbances in mucociliary transport were found in 25 cases. In 6 of the 8 studies of ciliary ul
- The costs and effectiveness of surveillance of communicable disease: a case study of HIV and AIDS in England and Wales.
- J Public Health Med. 1996 Dec;18(4):415-22. Unique Identifier : AIDSLINE MED/97176227
- Morris S; Gray A; Noone A; Wiseman M; Jathanna S; City University, London, UK.
- BACKGROUND: In England and Wales, surveillance of communicable disease is carried out and co-ordinated by the Public Health Laboratory Service (PHLS). The surveillance of HIV infection and AIDS is undertaken by the PHLS AIDS Centre at the Communicable Disease Surveillance Centre (CDSC). Epidemiological data derived fr
- The use and cost of hospital services by London AIDS patients with different AIDS defining conditions.
- J Public Health Med. 1996 Dec;18(4):457-64. Unique Identifier : AIDSLINE MED/97176233
- Beck EJ; Kupek EJ; Wadsworth J; Miller DL; Pinching AJ; Harris JR; Department of Epidemiology and Public Health, Imperial College School; of Medicine at St Mary's, London.
- BACKGROUND: Contracting for HIV service provision is now an established part of the National Health Service commissioning process. AIDS is a heterogeneous condition, comprising various opportunistic illnesses which require different services and which have different resource implications. This study describes the use
- Hematologic complications of HIV infection.
- Oncology (Huntingt). 1996 May;10(5):671-80. Unique Identifier : AIDSLINE MED/96336707
- Hambleton J; Department of Medicine, University of California, San Francisco, USA.
- Hematologic complications of HIV disease are commonly encountered by physicians and other health-care workers caring for patients infected with this virus. Ineffective hematopoiesis, infiltrative diseases of the bone marrow, nutritional deficiencies, peripheral destruction of blood cells secondary to splenomegaly or i
- AIDS activists meet to establish community-based standards for life insurance settlements [news]
- Oncology (Huntingt). 1996 May;10(5):712. Unique Identifier : AIDSLINE MED/96336710
- Role of thymic selection in the development of thymic lymphomas in TCR transgenic mice.
- Int Immunol. 1997 Jan;9(1):127-38. Unique Identifier : AIDSLINE MED/97196865
- Strzadala L; Miazek A; Matuszyk J; Kisielow P; Institute of Immunology and Experimental Therapy, Polish Academy of; Sciences, Wroclaw, Poland.
- To investigate the role of antigen receptor-mediated interactions in lymphomagenesis we have analyzed the influence of alpha beta TCR-mediated selection on the development of spontaneous thymic lymphomas, which appear with a high (up to 50%) frequency in mice expressing a transgenic TCR specific for the male antigen (
- The xid mutation plays an important role in delayed development of murine acquired immunodeficiency syndrome.
- Int Immunol. 1997 Jan;9(1):139-46. Unique Identifier : AIDSLINE MED/97196866
- Numata F; Hitoshi Y; Uehara S; Takatsu K; Department of Immunology, University of Tokyo, Japan.
- Infection of C57BL/6 mice with LP-BM5 murine leukemia virus MuLV) leads to the development of murine acquired immunodeficiency syndrome (MAIDS) characterized by abnormal lymphoproliferation, hypergammaglobulinemia and severe immunodeficiency. Progression of MAIDS is delayed in X chromosome-linked immunodeficient (XID)
- Modulation of proliferation and lymphokine secretion of murine CD4+ T cells and cloned Th1 cells by proteins of the extracellular matrix.
- Int Immunol. 1997 Jan;9(1):147-59. Unique Identifier : AIDSLINE MED/97196867
- Tschoetschel U; Schwing J; Frosch S; Schmitt E; Schuppan D; Reske-Kunz AB; Department of Dermatology, Johannes Gutenberg-University, Mainz,; Germany.
- In this study we investigated the co-stimulatory signaling capacity of diverse proteins of the extracellular matrix (ECM) for murine resting CD4+ T cells and Th1 clone cells, activated by immobilized anti-CD3 mAb. ECM proteins used in various concentrations had no effect on
- HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck.
- Int Immunol. 1997 Jan;9(1):53-64. Unique Identifier : AIDSLINE MED/97196858
- Morio T; Chatila T; Geha RS; Division of Immunology, Children's Hospital, Boston, MA 02115, USA.
- HIV major glycoprotein gp120 interacts with CD4 molecules and perturbs signaling through the TCR-CD3 complex. We examined the effects of gp120 on TCR-CD3-induced phosphorylation and activation of the src-type protein tyrosine kinases (PTK), fyn and lck. gp120 caused minimal changes in lck phosphorylation or lck enzyma
- Lack of Th1 or Th2 polarization of CD4+ T cell response induced by particulate antigen targeted to phagocytic cells.
- Int Immunol. 1997 Jan;9(1):91-103. Unique Identifier : AIDSLINE MED/97196862
- Sedlik C; Deriaud E; Leclerc C; Unite de Biologie ces Regulations Immunitaires, Institut Pasteur,; Paris, France.
- Several factors are involved in the selective activation of Th1 or Th2 subset of CD4+ T cells, such as the type of antigen-presenting cells, the dose of antigen, the route of immunization, etc. To analyze the influence of accessory cells on Th1/Th2 cell differentiation, we used a particulate antigen prepared by covale
- Dissection of the proposed base triple in human immunodeficiency virus TAR RNA indicates the importance of the Hoogsteen interaction.
- Biochemistry. 1997 Mar 25;36(12):3491-5. Unique Identifier : AIDSLINE MED/97238548
- Tao J; Chen L; Frankel AD; Department of Biochemistry and Biophysics, University of California,; San Francisco 94143-0448, USA.
- A single arginine residue within the RNA-binding domain of the human immunodeficiency virus Tat protein makes a critical sequence-specific contact to TAR RNA. Arginine as the free amino acid also binds specifically to TAR and induces a change in RNA conformation similar to that induced by Tat peptides. NMR and biochem
- Chemical cross-linking of the human immunodeficiency virus type 1 Tat protein to synthetic models of the RNA recognition sequence TAR containing site-specific trisubstituted pyrophosphate analogues.
- Biochemistry. 1997 Mar 25;36(12):3496-505. Unique Identifier : AIDSLINE MED/97238549
- Naryshkin NA; Farrow MA; Ivanovskaya MG; Oretskaya TS; Shabarova ZA; Gait MJ; Laboratory of Molecular Biology, Medical Research Council, Cambridge,; U.K.
- A chemical ligation procedure has been developed for the synthesis of oligoribonucleotides carrying a trisubstituted pyrophosphate (tsp) linkage in place of a single phosphodiester. Good yields of tsp were obtained when a single 2 -deoxynucleoside 5 to the tsp was used in the ligation reaction. A tsp linkage was founa
- Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin.
- Biochemistry. 1997 Apr 1;36(13):3941-9. Unique Identifier : AIDSLINE MED/97246586
- Szebeni A; Mehrotra B; Baumann A; Adam SA; Wingfield PT; Olson MO; Department of Biochemistry, University of Mississippi Medical Center,; Jackson 39216, USA.
- Nucleolar phosphoprotein B23 is a putative ribosome assembly factor with a relatively high affinity for peptides containing sequences of nuclear localization signals (NLSs) of the SV40 T-antigen type [Szebeni, A., Herrera, J. E., & Olson, O. J. 1995) Biochemistry 34, 8037-8042]. The effects of protein B23 on nuclea
- Psychiatric manifestations and magnetic resonance imaging in HIV-negative neurosyphilis.
- Biol Psychiatry. 1997 Feb 15;41(4):467-73. Unique Identifier : AIDSLINE MED/97187088
- Russouw HG; Roberts MC; Emsley RA; Truter R; Department of Psychiatry, University of Stellenbosch, South Africa.
- Neurosyphilis can mimic virtually any psychiatric disorder. Since there are no studies measuring the relationship between its psychiatric manifestations and neuroradiological findings, we performed magnetic resonance imaging (MRI) on 20 newly diagnosed patients with neurosyphi
- Neurophysiological changes associated with psychiatric symptoms in HIV-infected individuals without AIDS.
- Biol Psychiatry. 1997 Feb 15;41(4):474-87. Unique Identifier : AIDSLINE MED/97187089
- Baldeweg T; Catalan J; Pugh K; Gruzelier J; Lovett E; Scurlock H; Burgess A; Riccio M; Hawkins D; Academic Department of Psychiatry, Charing Cross & Westminster Medical; School, London, United Kingdom.
- HIV-1 infection may be complicated by a number of psychopathological conditions. While organic mental disorders, such as HIV-related psychosis and dementia , are late manifestations, mood disorders may occur during both asymptomatic and symptomatic stages of infection. The possible
- Elevated frontal lobe cytosolic choline levels in minimal or mild AIDS dementia complex patients: a proton magnetic resonance spectroscopy study.
- Biol Psychiatry. 1997 Feb 15;41(4):500-2. Unique Identifier : AIDSLINE MED/97187093
- English CD; Kaufman MJ; Worth JL; Babb SM; Drebing CE; Navia BA; Renshaw PF; Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02178,; USA.
- [Percutaneous liver biopsy: comparative study on the efficacy of and tolerance to the automatic tru-cut technique]
- An Med Interna. 1996 Sep;13(9):419-22. Unique Identifier : AIDSLINE MED/97122084
- Garcia Ordonez MA; Antunez Galvez JM; Aguilar Heredia Y; Colmenero Castillo JD; Causse Prados M; Juarez Fernandez C; Servicio de Medicina Interna, Hospital Regional Carlos Haya, Malaga.
- Percutaneous liver biopsy (PLB) is an useful tool in accurately diagnosing difuse hepatopathy and systemic procedures like fever of unknown origin (FUO) and human immunodeficiency virus infection. Present job compares two different PLB procedures, automatic tru-cut needle versus Menghini needle. We have achieved 143 P
- [Report of a case of T-cell peripheral lymphoblastic lymphoma in an HIV patient]
- An Med Interna. 1996 Sep;13(9):443-6. Unique Identifier : AIDSLINE MED/97122090
- Garcia de la Llana F; Mota Vargas R; Rovira Farre I; Pazlasso S; Alejo Pedrero M; Ambrojo P; Unidad Enfermedades Infecciosas, Hospital Regional Universitario; Infanta Cristina, Badajoz.
- T-cell lymphomas in human immunodeficiency virus infections are rare, first case have being described in 1987, by Presant. Our purpose is to report the first T-cell Lymphoma case without epidermotropism in an HIV patient in Extremadura, and pioneer in Spain . Clinic extensive and his
- Viral lesions of the mouth in HIV-infected patients.
- Dermatology. 1997;194(1):1-7. Unique Identifier : AIDSLINE MED/97183822
- Itin PH; Lautenschlager S; Department of Dermatology, University of Basel, Switzerland.
- Viral lesions of the mouth in patients with HIV infection are common and these diseases any be a marker for HIV and disease progression. We review the spectrum of oral viral manifestations and discuss treatment modalities. The most common Epstein-Barr virus (EBV)-induced disorder in HIV-infected patients is oral hairy
- Lichen amyloidosis presenting as a papular pruritus syndrome in a human-immunodeficiency-virus-infected man.
- Dermatology. 1997;194(1):62-4. Unique Identifier : AIDSLINE MED/97183835
- Goller MM; Cohen PR; Duvic M; Department of Dermatology, University of Texas-Houston Medical School; 77030, USA.
- A human-immunodeficiency-virus (HIV)-positive man presented with pruritic erythematous and flesh-colored papules on his arms and trunk of 1 year s duration. The lesions had previously been treated with oral ketoconazole and topical emollients with no improvement. Microscopic evaluation of lesional skin from his left f
- Remission of localized cutaneous leishmaniasis in a HIV-positive patient using systemic terbinafine [letter]
- Dermatology. 1997;194(1):85-6. Unique Identifier : AIDSLINE MED/97183842
- Gonzalez-Ruperez J; Javaloyas de Morlius M; Moreno Carazo A
- Demonstration of herpes virus 8 in a lymphangioma-like Kaposi's sarcoma occurring in a non-immunosuppressed patient [letter]
- Dermatology. 1997;194(1):90-1. Unique Identifier : AIDSLINE MED/97183846
- Noel JC; de Thier F; de Dobbeleer G; Heenen M
- [The clinico-epidemiological aspects of a case of Cryptococcus neoformans meningoencephalitis]
- Bacteriol Virusol Parazitol Epidemiol. 1993 Jan-Jun;38(1-2):36-8. Unique Identifier : AIDSLINE MED/97271806
- Rugina S; Rugina C; Zalupca L; Dinisov M; Spitalul Municipal Constanta.
- Dendritic cells: from ignored cells to major players in T-cell-mediated immunity.
- Int Arch Allergy Immunol. 1997 Apr;112(4):317-22. Unique Identifier : AIDSLINE MED/97258591
- Schuler G; Thurner B; Romani N; Department of Dermatology, University of Erlangen-Nurnberg, Erlangen,; Germany. schuler@derma.med.uni-erlangen.de
- Dendritic cells form a system of leukocytes specialized to stimulate resting T cells in vivo. Dendritic cells are crucial for the initiation of primary immune responses of both helper and cytotoxic T lymphocytes, and thus act as nature s adjuvant . The manifold specializations underlying this in vivo immunostimulator
- South African research into AIDS "cure" severely criticised [news]
- BMJ. 1997 Mar 15;314(7083):771. Unique Identifier : AIDSLINE MED/97236080
- Sidley P
- Doctor who refused HIV test is struck off register [news] [see comments]
- BMJ. 1997 Mar 22;314(7084):847. Unique Identifier : AIDSLINE MED/97246944
- Dyer C
- An ethical dilemma. Availability of antiretroviral therapy after clinical trials with HIV infected patients are ended [see comments]
- BMJ. 1997 Mar 22;314(7084):887-8. Unique Identifier : AIDSLINE MED/97246959
- Cleaton-Jones PE; Committee for Research on Human Subjects (Medical), University of the; Witwaterstand, Johannesburg, South Africa.
- Strident, but essential: the voices of people with AIDS [comment]
- BMJ. 1997 Mar 22;314(7084):888-9. Unique Identifier : AIDSLINE MED/97246960
- Busse P; NAPWA South Africa, Western Cape.
- Drug companies have a duty to continue treatment [comment]
- BMJ. 1997 Mar 22;314(7084):889. Unique Identifier : AIDSLINE MED/97246961
- Emery S; Cooper DA; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, Sydney, Australia.
- A case for goodwill [comment]
- BMJ. 1997 Mar 22;314(7084):890. Unique Identifier : AIDSLINE MED/97246962
- McLean GR; Department of Philosophy, University of the Witwaterstand,; Johannesburg, South Africa.
- A partnership to resolve the conundrum [comment]
- BMJ. 1997 Mar 22;314(7084):890-1. Unique Identifier : AIDSLINE MED/97246963
- King P; Roche Products, Wetwyn Garden City.
- Management of needlestick injuries would be easier if consent for donor" testing was not necessary [letter; comment]
- BMJ. 1997 Mar 22;314(7084):905. Unique Identifier : AIDSLINE MED/97246982
- Walker E; Wright P
- Trust me--I'm a doctor [see comments]
- BMJ. 1997 Mar 22;314(7084):910. Unique Identifier : AIDSLINE MED/97246984
- Craft N
- Discrimination, informed consent, and the HIV infected clinician [editorial]
- BMJ. 1997 Mar 29;314(7085):915-6. Unique Identifier : AIDSLINE MED/97253872
- Bayer R
- Intestinal absorption and first-pass elimination of 2', 3'-dideoxynucleosides following oral administration in rats.
- Biol Pharm Bull. 1996 Apr;19(4):599-603. Unique Identifier : AIDSLINE MED/97014131
- Hasegawa T; Juni K; Saneyoshi M; Kawaguchi T; Faculty of Pharmaceutical Sciences, Josai University, Japan.
- Intestinal absorption and first-pass elimination of 2 ,3 -dideoxynucleosides (ddNs), including 3 -azido-3 -deoxythymidine ( AZT ), 2 ,3 -dideoxyinosine (DDI) and 2 ,3 -didehydro-3 -deoxythymidine (D4T), following oral administration was investigated in
- Tax-independent stimulation of human T-cell leukemia virus type-I expression and differential effects on its infectivity by subtoxic and toxic doses of 3-methylcholanthrene.
- Cell Mol Biol Res. 1995;41(5):377-85. Unique Identifier : AIDSLINE MED/97021424
- Revazova T; Dombrovsky A; Lochelt M; Flugel RM; Aboud M; Department of Microbiology and Immunology, Ben Gurion University of; the Negev, Beer Sheva, Israel.
- Using the human T-cell leukemia virus type I (HTLV-I) infected SLB-I T-cell line, we showed in this study that 5-d treatment with the maximal subtoxic 3-methylcholanthrene (3-MC) dose (0.25 microgram/ml), as well as with a 3-MC dose that inhibits 50% of the cell growth (5 micrograms/ml), profoundly increased the level
- A probability-based approach for predicting HIV infection in a low prevalent population of injection drug users.
- Ann Epidemiol. 1997 Jan;7(1):28-34. Unique Identifier : AIDSLINE MED/97186950
- Cheng FK; Ford WL; Weber MD; Cheng SY; Kerndt PR; Los Angeles County Department of Health Services, HIV Epidemiology; Program, CA 90005, USA.
- This article proposes a method for estimating HIV risk in low-HIV-prevalent populations. Allard s risk probability model was used to compute individual risk scores. Based on a sample of 3854 injection drug users (IDUs) who were confidentially tested for HIV at five methadone treatment clinics in Los Angeles County, th
- The surgeon's database for AIDS: a collective review.
- J Am Coll Surg. 1997 Apr;184(4):403-12. Unique Identifier : AIDSLINE MED/97255342
- Flum DR; Wallack MK; Department of Surgery, St. Vincents Hospital and Medical Center, New; York, NY, USA.
- BACKGROUND: The human immunodeficiency virus infection and acquired immunodeficiency syndrome have had a dramatic effect on the practice of surgery. Critical issues include quantifying the risk encountered by surgeons when operating on infected patients, the benefits of chemoprophylaxis after injury by a health care w
- Resistance to HIV infection: the genes are only part of the solution.
- Trends Microbiol. 1997 Jan;5(1):2-4. Unique Identifier : AIDSLINE MED/97177721
- Clerici M; Clivio A; Shearer GM; Cattedra di Immunologia, Padiglione LITA, H.L. Sacco, Universita di; Milano, Italy.
- Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.
- Structure. 1996 Jul 15;4(7):853-60. Unique Identifier : AIDSLINE MED/96434330
- Hsiou Y; Ding J; Das K; Clark AD Jr; Hughes SH; Arnold E; Center for Advanced Biotechnology and Medicine (CABM), Piscataway, NJ,; USA.
- BACKGROUND: HIV-1 reverse transcriptase (RT) is a major target for anti-HIV drugs. A considerable amount of information about the structure of RT is available, both unliganded and in complex with template-primer or non-nucleoside RT inhibitors (NNRTIs). But significant conformational differences in the p66 polymerase
- Arterial homografts--a possible solution to an infective dilemma.
- Cardiovasc Surg. 1996 Dec;4(6):796-800. Unique Identifier : AIDSLINE MED/97165252
- Wagstaff SA; Grigg MJ; Vascular Surgical Unit, Alfred Hospital, Camberwell, Victoria,; Australia.
- Seven patients with infected arterial conduits (six with prosthetic bypass grafts and one autogenous vein anastomosis) with ten limbs at risk (three patients with bilateral groin infection) are reported. The most common site for infection was the groin and the most frequent organism cultured was Staphylococcus aureus.
- Broad plan essential for tuberculosis elimination, say researchers [news]
- Am J Health Syst Pharm. 1997 Feb 15;54(4):361, 365. Unique Identifier : AIDSLINE MED/97196443
- Status and future of vaccines for adults.
- Am J Health Syst Pharm. 1997 Feb 15;54(4):379-87. Unique Identifier : AIDSLINE MED/97196447
- Grabenstein JD; U.S. Army Medical Department, School of Pharmacy, University of North; Carolina, Chapel Hill 27599-7360, USA. jgrabens@sph.unc.edu
- The current status and future prospects of vaccines for adults are discussed. For every child in America who dies of a vaccine-preventable disease, about 400 adults die of such a disease. Evidence of the merit of influenza vaccination continues to accumulate, yet
- An erythematous rash, diarrhea, failure to thrive, and lymphadenopathy in a 3-month-old girl [clinical conference]
- Ann Allergy Asthma Immunol. 1997 Mar;78(3):253-8. Unique Identifier : AIDSLINE MED/97242092
- Sicherer SH; Lederman HM; Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland,; USA.
- Aeroallergen-specific IgE changes in individuals with rapid human immunodeficiency virus disease progression.
- Ann Allergy Asthma Immunol. 1997 Mar;78(3):301-6. Unique Identifier : AIDSLINE MED/97242101
- Goetz DW; Webb EL Jr; Whisman BA; Freeman TM; Allergy-Immunology Department, Wilford Hall Medical Center, Lackland; AFB, Texas, USA.
- BACKGROUND: Progression of human immunodeficiency virus type 1 HIV-1) infection to the acquired immunodeficiency syndrome AIDS) is associated with elevated total IgE; however, previous cross-sectional studies have differed in their assessment of concurrent changes in allergic disease prevalence. OBJECTIVE: Assessment
- Retinal findings and characteristics in AIDS patients with systemic Mycobacterium avium-intracellulare complex and toxoplasmic encephalitis.
- Ophthalmic Surg Lasers. 1997 Jan;28(1):50-4. Unique Identifier : AIDSLINE MED/97183166
- Arevalo JF; Quiceno JI; Garcia RF; McCutchan JA; Munguia D; Nelson JA; Freeman WR; Department of Ophthalmology, Shiley Eye Center, La Jolia, CA; 92093-0946, USA.
- BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the incidence and characteristics of retinal and choroidal manifestations of toxoplasmosis and/or Mycobacterium avium-intracellulare complex (MAC) in patients with acquired immunodeficiency syndrome (AIDS). PATIENTS AND METHODS: The authors analyzed t
- Respiratory isolation of patients with suspected pulmonary tuberculosis in an inner-city hospital.
- Acad Emerg Med. 1997 Feb;4(2):138-41. Unique Identifier : AIDSLINE MED/97196430
- Gaeta TJ; Webheh W; Yazji M; Ahmed J; Yap W; Department of Emergency Medicine, St. Barnabas Hospital, Bronx, NY; 10457-2594, USA. tgaeta@mem.po.com
- OBJECTIVE: To identify clinical factors that predict which patients presenting to the ED with pneumonia will require respiratory isolation for suspected tuberculosis and to evaluate a protocol for rapid identification of patients at risk for pulmonary tuberculosis (PTB). METHODS: To identify potential clinical indicat
- Lymphogranuloma venereum: a case report in an Italian traveller.
- New Microbiol. 1997 Jan;20(1):83-6. Unique Identifier : AIDSLINE MED/97189437
- Monno R; Pastore G; Lamargese V; Leone E; Valenza MA; Angarano G; Institute of Medical Microbiology, University of Bari, Italy.
- A 38-year-old man with a recent history of travel in India and unprotected sexual intercourse with Indian women, was admitted with painful enlarged lymphnodes predominantly in the right inguinal area. Diagnosis of lymphogranuloma venereum was made by means of a positive immunofluore
- Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk.
- Mol Med. 1997 Jan;3(1):23-36. Unique Identifier : AIDSLINE MED/97206137
- Zimmerman PA; Buckler-White A; Alkhatib G; Spalding T; Kubofcik J; Combadiere C; Weissman D; Cohen O; Rubbert A; Lam G; Vaccarezza M; Kennedy PE; Kumaraswami V; Giorgi JV; Detels R; Hunter J; Chopek M; Berger EA; Fauci AS; Nutman TB; Murphy PM; Laboratory of Parasitic Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-0425, USA.
- BACKGROUND: CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5 allele (designated here as CCR5-2) was identified that confers resistance to HIV-1 infection in homozygotes and slows the rate of progression to AIDS
- Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.
- Mol Med. 1997 Jan;3(1):60-71. Unique Identifier : AIDSLINE MED/97206140
- Wallace M; Scharko AM; Pauza CD; Fisch P; Imaoka K; Kawabata S; Fujihashi K; Kiyono H; Tanaka Y; Bloom BR; Malkovsky M; Department of Medical Microbiology and Immunology, University of; Wisconsin Medical School, Madison 53706, USA.
- BACKGROUND: Antiviral cellular immune responses may influence immunological homeostasis in HIV-infected persons. Recent data indicate that V gamma 9/V delta 2 T lymphocytes display potent cytotoxic activities against human cells infected with certain viruses including HIV. Understanding the role of gamma delta T cells
- HIV-1 antibody--debris or virion? [letter] [see comments] [published erratum appears in Nat Med 1997 Jun;3(6):591]
- Nat Med. 1997 Apr;3(4):366-7. Unique Identifier : AIDSLINE MED/97249254
- Parren WH; Burton DR; Sattentau QJ
- HIV CCR5 resistance incomplete [news]
- Nat Med. 1997 Apr;3(4):372-3. Unique Identifier : AIDSLINE MED/97249257
- Smith O
- HIV accessory proteins as therapeutic targets.
- Nat Med. 1997 Apr;3(4):389-94. Unique Identifier : AIDSLINE MED/97249266
- Miller RH; Sarver N; Targeted Interventions Branch, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-7620, USA.
- Unconventional structure of tRNA(Lys)SUU anticodon explains tRNA's role in bacterial and mammalian ribosomal frameshifting and primer selection by HIV-1.
- RNA. 1997 Apr;3(4):420-8. Unique Identifier : AIDSLINE MED/97240388
- Agris PF; Guenther R; Ingram PC; Basti MM; Stuart JW; Sochacka E; Malkiewicz A; Department of Biochemistry, North Carolina State University, Raleigh,; North Carolina 27695, USA. agris@bchserver.bch.ncsu.edu
- Transfer RNA(Lys)SUU, with a 5-modified-2-thiouridine at wobble position 34, facilitates -1 frameshifts for correct translation of the Escherichia coli DNA polymerase gamma subunit and retroviral polymerases. Peptidyl-tRNA(Lys)SUU prematurely terminates translation more often than other tRNAs. In order to determine if
- Living with needlestick injuries.
- J Can Dent Assoc. 1997 Apr;63(4):283-6. Unique Identifier : AIDSLINE MED/97270829
- David HT; David YM; Faculty of Dentistry, University of British Columbia.
- Exposure to contaminated sharp objects is one of the inherent hazards of working in a clinical setting. Today, primarily due to concerns about possible HIV infection, a terror-factor strikes mortal fear, whether imagined or real, in the heart of individuals who suffer a subcutaneous sharp object injury. The psycholo
- An atlas of HIV-associated oral lesions: a new classification and diagnostic criteria.
- J Can Dent Assoc. 1997 Apr;63(4):288-9, 292-4. Unique Identifier : AIDSLINE MED/97270830
- Wiebe CB; Epstein JB; Department of Clinical Dental Sciences, Faculty of Dentistry,; University of British Columbia, Vancouver.
- Many oral lesions are strongly associated with HIV infection. Along with the HIV-infected individual s T helper cell count (CD4 cell count), they indicate the severity of immune suppression. It is important for dental professionals to recognize these lesions early, as it alerts patients to their HIV status, and allows
- Tuberculosis in Shelby County and Tennessee correctional facilities.
- Tenn Med. 1997 Apr;90(4):138-40. Unique Identifier : AIDSLINE MED/97243246
- Fountain FF Jr
- Human immunodeficiency virus in women: mucocutaneous manifestations.
- Clin Dermatol. 1997 Jan-Feb;15(1):93-111. Unique Identifier : AIDSLINE MED/97187206
- Wright SW; Johnson RA; Division of Dermatology, Harvard Medical School, Deaconess Hospital,; Boston, MA 02215, USA.
- Sporadic bovine leukosis associated with ataxia and tibiotarsal joint swelling: a case report.
- Can Vet J. 1994 Dec;35(12):777-9. Unique Identifier : AIDSLINE MED/97271822
- Oliver-Espinosa O; Physick-Sheard PW; Wollenberg GK; Taylor J; Department of Clinical Studies, Ontario Veterinary College, University; of Guelph.
- Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor.
- Cancer Res. 1997 Apr 15;57(8):1447-51. Unique Identifier : AIDSLINE MED/97262030
- Goldman CK; Rogers BE; Douglas JT; Sosnowski BA; Ying W; Siegal GP; Baird A; Campain JA; Curiel DT; Gene Therapy Program, University of Alabama at Birmingham, 35294, USA.
- Kaposi s sarcoma (KS) is a major AIDS-related malignancy associated with significant morbidity and mortality. Current chemotherapeutic regimens are associated with a dismal prognosis. In an effort to develop a new approach to KS treatment, we devised a gene therapy-based adenovirus retargeting schema that redirects th
- Laparoscopic approach to interstitial pregnancy.
- J Am Assoc Gynecol Laparosc. 1996 May;3(3):439-41. Unique Identifier : AIDSLINE MED/97238374
- Woodland MB; DePasquale SE; Molinari JA; Sagullo CC; Pennsylvania Hospital, Department of Obstetrics and Gynecology, 8th; and Spruce Streets, Philadelphia, PA 19107, USA.
- A 23-year-old woman was diagnosed with a 5-cm interstitial pregnancy by transvaginal ultrasound. In addition, she was positive for the human immunodeficiency virus. She underwent laparoscopic cornual excision of the ectopic gestation and was discharged home the next day.
- Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125.
- Fold Des. 1996;1(2):157-65. Unique Identifier : AIDSLINE MED/97233153
- Campbell AP; Sykes BD; Norrby E; Assa-Munt N; Dyson HJ; Department of Molecular Biology, Scripps Research Institute, La Jolla,; California 92037, USA.
- BACKGROUND: The conformational preferences of a number of peptides with sequences related to the envelope glycoproteins of HIV-1 have been investigated in the past few years. Similar studies have not been made for HIV-2, which is a distinct virus with similar physiological effects to those of HIV-1. The discovery of c
- Flow-cytometric assessment of in vivo cytokine-producing monocytes in HIV-infected patients.
- Clin Immunol Immunopathol. 1997 Apr;83(1):60-7. Unique Identifier : AIDSLINE MED/97242249
- Estcourt C; Rousseau Y; Sadeghi HM; Thieblemont N; Carreno MP; Weiss L; Haeffner-Cavaillon N; INSERM U430, Hopital Broussais, Paris, France.
- We have used two-color flow cytometry to study in vivo monocytic cytokine production at the single-cell level in HIV-infected patients. We demonstrated the presence of intracellular IL-1 alpha, IL-1 beta, IL-1ra, and TNF alpha in circulating CD14+ monocytes from HIV-infected patients. The specificity of intracellular
- Pathologic correlations between ocular and cerebral lesions in 36 AIDS patients.
- Clin Neuropathol. 1997 Jan-Feb;16(1):45-8. Unique Identifier : AIDSLINE MED/97172311
- Leger F; Vital C; Vital A; Morlat P; Ragnaud JM; Dupon M; Neuropathology Department, (Pellegrin Hospital), Bordeaux, France.
- The eyes and brain have rarely been studied simultaneously in AIDS patients. We have examined both the eyes and brain of 36 patients autopsied these past 3 years. Ten cases had concomitant involvement of eyes and brain by the same pathology: cryptococcus neoformans in 1, aspergillus in another,
- In vitro susceptibility of 115 isolates of Candida to amphotericin B, fluconazole and itraconazole.
- Drugs Exp Clin Res. 1996;22(6):301-7. Unique Identifier : AIDSLINE MED/97187303
- Mallie M; Bastide JM; Immunology-Parasitology Laboratory, Faculty of Pharmacy, Montpellier,; France.
- Opportunistic fungal infections are an increasingly important cause of morbidity and mortality particularly due to Candida species (1). There is also an increase of candidosis especially ascribed to acquired or induced immunodeficiency syndromes or in the event of long-term antibiotic, immuno-suppressor or cytotoxic t
- Changes in HIV-related behaviors among heterosexual alcoholics following addiction treatment.
- Drug Alcohol Depend. 1997 Jan 10;44(1):47-55. Unique Identifier : AIDSLINE MED/97183860
- Avins AL; Lindan CP; Woods WJ; Hudes ES; Boscarino JA; Kay J; Clark W; Hulley SB; Department of Epidemiology and Biostatistics, University of; California, San Francisco, USA.
- In order to measure changes in HIV-related behaviors among heterosexual alcoholics following treatment, we conducted a prospective cohort study of 700 self-identified alcoholics recruited from five public alcohol treatment centers, all of which included HIV risk-reduction counseling. Respondents underwent an HIV antib
- Effects of HIV seropositivity and drug abuse on cognitive function.
- Eur Neurol. 1997;37(1):48-52. Unique Identifier : AIDSLINE MED/97170729
- Grassi MP; Perin C; Clerici F; Zocchetti C; Borella M; Cargnel A; Mangoni A; Department of Neurology, L. Sacco Hospital, Milan, Italy.
- Fifty-eight HIV-positive drug abusers and 22 HIV-positive nondrug abusers at stages II-III and IV of the Centers for Disease Control classification were evaluated neuropsychologically. The study confirmed previous findings that drug abuse has a negative influence on cognitive function. It also emerges that seropositiv
- Multiple sites of post-activation CD8+ T cell disposal.
- Eur J Immunol. 1997 Mar;27(3):577-83. Unique Identifier : AIDSLINE MED/97234521
- Wack A; Corbella P; Harker N; Crispe IN; Kioussis D; Division of Molecular Immunology, National Institute for Medical; Research, London, GB.
- Antigen-triggered activation of T cells leads to a sequence of differentiation steps including up-regulation of activation markers, blast formation, proliferation, delivery of effector functions, and ultimately apoptosis. It is still controversial in which anatomical site activation-induced apoptosis and elimination o
- B7-1-dependent co-stimulation results in qualitatively and quantitatively different responses by CD4+ and CD8+ T cells.
- Eur J Immunol. 1997 Mar;27(3):598-608. Unique Identifier : AIDSLINE MED/97234524
- Deeths MJ; Mescher MF; The Department of Laboratory Medicine and Pathology, University of; Minnesota, Minneapolis 55455, USA.
- To characterize better the co-stimulatory activity of native B7-1 in the absence of other receptor/ligand interactions that might contribute to the response, B7-1 was purified by monoclonal antibody (mAb) affinity chromatography. Immobilization of purified B7-1 with anti-T cell receptor (TCR) mAb on cell-sized latex m
- Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.
- Eur J Immunol. 1997 Mar;27(3):633-40. Unique Identifier : AIDSLINE MED/97234528
- Webb LM; Foxwell BM; Feldmann M; Kennedy Institute of Rheumatology, London, GB.
- Interleukin (IL)-4 is considered to be essential for T helper Th)2 cell development, yet in areas of primary T cell activation, CD4+ cells are its only source. This implies that other signals must drive the initial expression of IL-4 production. The role of CD28 co-stimulation in Th2 subset development has been descri
- Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12.
- Eur J Immunol. 1997 Mar;27(3):641-6. Unique Identifier : AIDSLINE MED/97234529
- Yokoi H; Kato K; Kezuka T; Sakai J; Usui M; Yagita H; Okumura K; Department of Ophthalmology, Tokyo Medical College Hospital, Japan.
- Experimental autoimmune uveoretinitis (EAU) induced by immunization with interphotoreceptor retinoid-binding protein IRBP), a retinal self antigen, has been regarded to be a typical T helper type 1 (Th1)-mediated inflammatory disease. In this study, we examined the effect of a neutralizing monoclonal antibody (mAb) to
- Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression.
- Eur J Immunol. 1997 Mar;27(3):647-52. Unique Identifier : AIDSLINE MED/97234530
- Gollob JA; Kawasaki H; Ritz J; Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical; School, Boston, MA 02115, USA. jared_gollob@macmailgw.dfci.harvard.edu
- Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) are mutually antagonistic cytokines that stimulate CD4+ T cells to develop into either Th1 or Th2 cells. One feature of Th2 differentiation in mice is the loss of IL-12-induced Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN-gamma in
- Altered Th1/Th2 balance associated with non-major histocompatibility complex genes in collagen-induced arthritis in resistant and non-resistant rat strains.
- Eur J Immunol. 1997 Mar;27(3):695-9. Unique Identifier : AIDSLINE MED/97234537
- Mussener A; Lorentzen JC; Kleinau S; Klareskog L; Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden.; muessner@minerva.data.ks.se
- Collagen-induced arthritis (CIA) is a T cell-dependent disease in which susceptibility is controlled by genes both within and outside the major histocompatibility complex (MHC). In the present study, we compared the humoral responses and kinetics of cytokine secretion patterns in the draining lymph nodes of arthritis-
- Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen.
- Eur J Immunol. 1997 Mar;27(3):782-7. Unique Identifier : AIDSLINE MED/97234548
- Tsuji T; Hamajima K; Ishii N; Aoki I; Fukushima J; Xin KQ; Kawamoto S; Sasaki S; Matsunaga K; Ishigatsubo Y; Tani K; Okubo T; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Japan.
- B7 co-stimulation is essential for activating resting T cells following antigen recognition by the T cell receptor. To determine whether B7 has adjuvant activities on human immunodeficiency virus type-1 (HIV-1)-specific immunity induced by inoculation of a plasmid encoding HIV-1 env and rev (DNA vaccine), B7-1 and B7-
- Chronic pneumonia caused by Rhodococcus equi in a patient without impaired immunity.
- Eur Respir J. 1997 Jan;10(1):248-50. Unique Identifier : AIDSLINE MED/97184753
- Linares MJ; Lopez-Encuentra A; Perea S; Pneumology Service, Hospital Universitario, 12 de Octubre, Madrid,; Spain.
- A 48 year old, human immunodeficiency virus (HIV)-negative, immunocompetent male patient had a chronic progressive pulmonary infiltrate, without radiological cavitation, in the middle lobe of the right lung produced by Rhodococcus equi. He reported direct contact with a diseased dog. The patient was diagnosed by thora
- Endobronchial lesions in a non-AIDS patient with disseminated Mycobacterium avium-intracellulare infection.
- Eur Respir J. 1997 Feb;10(2):497-9. Unique Identifier : AIDSLINE MED/97195249
- Shih JY; Wang HC; Chiang IP; Yang PC; Luh KT; Dept of Internal Medicine, National Taiwan University Hospital,; Taipei, Republic of China.
- A 34 year old female developed Mycobacterium avium-intracellulare infection with generalized lymphadenopathy, hepatosplenomegaly, pulmonary infiltration, pleural effusion and endobronchial polypoid lesions. M. avium-intracellulare was identified by means of sputum cultures, pleural effusion culture and lymph node cult
- Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160.
- FEBS Lett. 1997 Mar 17;405(1):68-72. Unique Identifier : AIDSLINE MED/97248198
- Decroly E; Benjannet S; Savaria D; Seidah NG; J.A. DeSeve Laboratory of Biochemical Neuroendocrinology, University; of Montreal, QC, Canada.
- The intracellular proteolytic processing of HIV envelope glycoprotein gp160 into gp120/gp41 is an essential step for virus infectivity. Several convertases, belonging to the pro-protein convertase family, have been proposed as candidate gp160 processing enzymes. Here we demonstrate using RT-PCR that resting human T4 l
- Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice.
- Diabetes. 1997 Apr;46(4):572-82. Unique Identifier : AIDSLINE MED/97230218
- Baxter AG; Kinder SJ; Hammond KJ; Scollay R; Godfrey DI; Centenary Institute of Cancer Medicine and Cell Biology, Camperdown,; Australia. a.baxter@centenary.usyd.edu.au
- NOD mice develop spontaneous IDDM as a result of T-cell-mediated autoimmune destruction of pancreatic beta-cells. It is not known why these T-cells become autoreactive, nor is it clear whether the breakdown in self-tolerance reflects a general problem in T-cell development or a selective defect in an as yet undefined
- Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells.
- Diabetes. 1997 Apr;46(4):589-98. Unique Identifier : AIDSLINE MED/97230220
- Scott FW; Cloutier HE; Kleemann R; Woerz-Pagenstert U; Rowsell P; Modler HW; Kolb H; Nutrition Research Division, Health Canada, Sir Frederick Banting; Research Centre, Ottawa, Ontario. fscott@hpb.hwc.ca
- Certain diets can have major effects on the development of IDDM in DP-BB rats, but data are scant on the timing, dose, and mechanisms involved. We therefore determined the dose response, timing, and duration of exposure required to induce diabetes, and characterized the effects of nutritionally adequate diets with wid
- Pancreatic ductal changes in HIV-infected patients.
- Gastrointest Endosc. 1997 Jan;45(1):59-63. Unique Identifier : AIDSLINE MED/97165410
- Barthet M; Chauveau E; Bonnet E; Petit N; Bernard JP; Gastaut JA; Sahel J; Department of Gastroenterology and Hepatology, Hopital; Sainte-Marguerite, Marseille, France.
- BACKGROUND: AIDS-related sclerosing cholangitis occurs in patients with advanced immunodeficiency, but ductal pancreatic alterations have not been evaluated in large series. METHODS: Twenty-nine consecutive patients with a mean age of 33 years underwent ERCP for biliary work-up. Complete pancreatography was obtained i
- Complications following percutaneous endoscopic gastrostomy and subsequent catheter replacement in children and young adults.
- Gastrointest Endosc. 1997 Jan;45(1):64-71. Unique Identifier : AIDSLINE MED/97165411
- Fox VL; Abel SD; Malas S; Duggan C; Leichtner AM; Combined Program in Pediatric Gastroenterology and Nutrition,; Children's Hospital, Harvard Medical School, Boston, Massachusetts; 02115, USA.
- BACKGROUND: Percutaneous endoscopic gastrostomy has gained wide acceptance for patients who require prolonged tube feeding support. We sought to identify complications and associated risk factors of endoscopic gastrostomy and subsequent catheter replacement in pediatric patients. METHODS: Medical records were reviewed
- Women living with HIV/AIDS: the dual challenge of being a patient and caregiver.
- Health Soc Work. 1997 Feb;22(1):53-62. Unique Identifier : AIDSLINE MED/97173518
- Hackl KL; Somlai AM; Kelly JA; Kalichman SC; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53202.
- More than 60,000 women in the United States have been diagnosed with AIDS, and millions of women worldwide are infected with HIV. Most of these women will die at an early age, leaving their children motherless. During their HIV illness, women confront the challenge of being both patien
- Of magic bullets and social justice: emerging challenges of recent advances in AIDS treatment.
- Health Soc Work. 1997 Feb;22(1):70-4. Unique Identifier : AIDSLINE MED/97173520
- Linsk NL; Keigher SM; Midwest AIDS Training and Education Center, Chicago, IL, USA.
- Persistent infiltration of CD45RC- CD4+ T cells, Th2-like effector cells, in prolonging hepatic allografts in rats pretreated with a donor-specific blood transfusion.
- Hepatology. 1997 Apr;25(4):1008-13. Unique Identifier : AIDSLINE MED/97250929
- Miyanari N; Yamaguchi Y; Matsuno K; Tominaga A; Goto M; Ichiguchi O; Mori K; Ogawa M; Department of Surgery II, Kumamoto University Medical School, Japan.
- A single intravenous injection of freshly heparinized blood from a donor-specific blood transfusion (DST) seven days before transplantation significantly prolongs the subsequent survival of hepatic allografts from ACI(RT1a) to LEW(RT1(1)) rats. We used W3/25 (anti-CD4) and OX22 (anti-CD45RC: an isoform of leukocyte-co
- Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B.
- Hepatology. 1997 Apr;25(4):1022-7. Unique Identifier : AIDSLINE MED/97250931
- Penna A; Del Prete G; Cavalli A; Bertoletti A; D'Elios MM; Sorrentino R; D'Amato M; Boni C; Pilli M; Fiaccadori F; Ferrari C; Cattedra Malattie Infettive, Universita di Parma, Italy.
- The cytokine pattern secreted by T cells on viral antigen recognition is believed to exert a profound influence on both the type of disease caused by the infecting agent and the final outcome of the viral infection. To characterize the cytokine pattern associated with spontaneous resolution of acute hepatitis B, we an
- In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset.
- Hepatology. 1997 Apr;25(4):791-6. Unique Identifier : AIDSLINE MED/97250895
- Harada K; Van de Water J; Leung PS; Coppel RL; Ansari A; Nakanuma Y; Gershwin ME; Division of Rheumatology, Allergy and Clinical Immunology, School of; Medicine, University of California, Davis 95616, USA.
- Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of the intrahepatic bile ducts. It is generally believed that cellular immune mechanisms, particularly involving T cells, result in this bile duct damage. The relative strength of Th1 and Th2 responses has recently been propose
- Clinical manifestations of tuberculosis: molecular mechanisms [editorial]
- Indian J Chest Dis Allied Sci. 1997 Jan-Mar;39(1):1-4. Unique Identifier : AIDSLINE MED/97255039
- Sharma SK; Mohan A
- NASBA technology: isothermal RNA amplification in qualitative and quantitative diagnostics.
- Immunol Invest. 1997 Jan-Feb;26(1-2):15-28. Unique Identifier : AIDSLINE MED/97189351
- Romano JW; Williams KG; Shurtliff RN; Ginocchio C; Kaplan M; Advanced BioScience Laboratories, Inc., Kensington, MD 20895, USA.
- Nucleic acid amplification technologies allow for the development of highly sensitive and specific diagnostic assays. The capacity to amplify and detect analyte targets, which may be present in a clinical sample as a single copy; is characteristic of many of these amplification technologies. NASBA is an isothermal met
- HTLV-associated diseases: human retroviral infection and cutaneous T-cell lymphomas.
- Immunol Invest. 1997 Jan-Feb;26(1-2):231-42. Unique Identifier : AIDSLINE MED/97189368
- Fujihara K; Goldman B; Oseroff AR; Glenister N; Jaffe ES; Bisaccia E; Pincus S; Greenberg SJ; Department of Neurology, Roswell Park Cancer Institute, Buffalo, New; York 14263, USA.
- An array of neurologic, oncologic, and autoimmune disorders are associated with infection with the human pathogenic retroviruses human T-cell leukemia virus types I and II (HTLV-I, II), as well as the human immunodeficiency viruses (HIV). The cutaneous T-cell lymphomas, mycosis fungoides (MF) and its hematogenous vari
- Concerted use of immunologic and ultrastructural analyses in diagnostic medicine: immunoelectron microscopy and correlative microscopy.
- Immunol Invest. 1997 Jan-Feb;26(1-2):29-38. Unique Identifier : AIDSLINE MED/97189352
- Miller SE; Howell DN; Department of Microbiology, Duke University Medical Center, Durham,; North Carolina 27710, USA.
- Electron microscopy (EM) is a valuable tool in diagnostic medicine, and in some cases, can be enhanced by immunological methods. A major medical application of EM, diagnostic virology, can frequently be augmented by employment of immunological reagents. Three immunoelectron microscopy (IEM) methods, aggregation, coati
- Rapid diagnosis of periodontal infections: findings in AIDS patients.
- Immunol Invest. 1997 Jan-Feb;26(1-2):55-65. Unique Identifier : AIDSLINE MED/97189354
- Zambon JJ; State University of New York at Buffalo, School of Dental Medicine; 14214, USA.
- A small number of bacterial pathogens in the human oral cavity cause the different forms of periodontal disease. Of the approximately two hundred different oral bacterial species, about a dozen have been associated with these diseases including localized juvenile periodontitis, rapidly progressing periodontitis, and a
- Branched DNA for quantification of viral load.
- Immunol Invest. 1997 Jan-Feb;26(1-2):9-13. Unique Identifier : AIDSLINE MED/97189350
- Wilber JC; Chiron Corporation, Emeryville, California 94608, USA.
- This is a summary of a presentation made at the 13th International Convocation on Immunology. Nucleic acids in patient samples can be quantified directly using a solid phase nucleic acid hybridization assay based on branched DNA (bDNA) signal amplification technology. For example, HIV RNA is detected in a plasma sampl
- Childhood needlestick injuries in the Dublin metropolitan area.
- Ir Med J. 1997 Mar;90(2):66-9. Unique Identifier : AIDSLINE MED/97258986
- Nourse CB; Charles CA; McKay M; Keenan P; Butler KM; Our Lady's Hospital for Sick Children, Crumlin, Dublin.
- Childhood needlestick injuries and other risk exposures outside of hospital are becoming increasingly common. A retrospective review of casenotes to ascertain the incidence, epidemiology and adequacy of management and follow-up of exposures in the Dublin metropolitan area revealed 52 cases between July 1995 and Octobe
- Immunomodulatory assays to study structure-activity relationships of thalidomide.
- Immunopharmacology. 1997 Jan;35(3):203-12. Unique Identifier : AIDSLINE MED/97196844
- Shannon EJ; Morales MJ; Sandoval F; Laboratory Research Branch G.W. Long Hansen's Disease Center,; Louisiana State University, Baton Rouge 70894, USA.
- Thalidomide, which has a long history of tragedy because of its ability to cause severe birth defects, is very effective in alleviating erythema nodosum leprosum in leprosy patients and aphthous ulcers in AIDS patients. The causes of these inflammatory diseases and the mechanism by which thalidomide diminishes them ar
- In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.
- Immunopharmacology. 1997 Jan;35(3):229-35. Unique Identifier : AIDSLINE MED/97196847
- See DM; Broumand N; Sahl L; Tilles JG; Department of Medicine, U.C. Irvine Medical Center, Orange 92668, USA.
- Extracts of Echinacea purpurea and Panax ginseng were evaluated for their capacity to stimulate cellular immune function by peripheral blood mononuclear cells (PBMC) from normal individuals and patients with either the chronic fatigue syndrome or the acquired immunodeficiency syndrome. PBMC isolated on a Ficoll-hypaqu
- Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes.
- Immunopharmacology. 1997 Jan;35(3):273-82. Unique Identifier : AIDSLINE MED/97196852
- Hasegawa T; Kimura Y; Hiromatsu K; Kobayashi N; Yamada A; Makino M; Okuda M; Sano T; Nomoto K; Yoshikai Y; Research Laboratories, Chlorella industries Co., Ltd., Fukuoka, Japan.
- We have previously reported that oral administration of hot water extract of Chlorella vulgaris (CVE) enhances resistance to Listeria monocytogenes through augmentation of Listeria-specific cell-mediated immunity in normal mice and mice with murine acquired immunodeficiency syndrome (MAIDS) caused by murine leukemia v
- [Significance of T4 cells in pollinosis and colitis]
- Hautarzt. 1997 Jan;48(1):55. Unique Identifier : AIDSLINE MED/97205938
- Werfel T; Kapp A; Dermatologische Klinik und Poliklinik, Medizinische Hochschule; Hannover.
- [HIV-associated skin diseases]
- Hautarzt. 1997 Jan;48(1):58-72. Unique Identifier : AIDSLINE MED/97205939
- Plettenberg A; Ramsauer J; Meigel W; Abteilung Dermatologie, Allgemeines Krankenhaus St. Georg, Hamburg.
- [HIV-associated non-Hodgkin's lymphomas (HIV-NHL) in the area of the head-neck]
- HNO. 1997 Jan;45(1):11-6. Unique Identifier : AIDSLINE MED/97205951
- Riederer A; Dreher A; Zietz C; Bogner J; Klinik und Poliklinik fur Hals-, Nasen- und Ohrenkranke,; Ludwig-Maximilians-Universitat Munchen.
- The life span of HIV-infected patients has increased because of anti-retroviral therapy and improved means for treating opportunistic infections. However, HIV infection and subsequent immunosuppression result in an increased risk of high-grade B-cell lymphomas. The purpose of this study was to determine the incidence,
- HIV-proteinase inhibitors in the management of HIV-infection.
- J Antimicrob Chemother. 1996 Dec;38(6):921-5. Unique Identifier : AIDSLINE MED/97176066
- Moyle GJ; Barton SE; Kobler Clinic, Chelsea and Westminster Hospital, London, UK.
- Stimulation of blood mononuclear cells of atopic children with the relevant allergen induces the release of eosinophil chemotaxins such as IL-3, IL-5, and GM-CSF.
- J Asthma. 1997;34(2):141-52. Unique Identifier : AIDSLINE MED/97243437
- Lantero S; Sacco O; Scala C; Rossi GA; Pulmonary Division, G. Gaslini Institute, Genoa, Italy.
- Peripheral blood mononuclear cells (PBMC) from 10 atopic asthmatic children (atopics), sensitized to Dermatophagoides pteronyssinus (Dp), and from 5 nonatopic healthy children controls) were stimulated with Dp extract or with birch extract Be). After 6 days we tested the supernatant s (Sn) chemotactic activity toward
- Purification and characterization of Mycoplasma penetrans Ca2+/Mg2+-dependent endonuclease.
- J Bacteriol. 1997 Apr;179(7):2210-20. Unique Identifier : AIDSLINE MED/97234632
- Bendjennat M; Blanchard A; Loutfi M; Montagnier L; Bahraoui E; Laboratory of Immunovirology UFR SVT, University of Paul Sabatier,; Toulouse, France.
- The major nuclease from Mycoplasma penetrans has been purified to homogeneity. The enzyme seems to be present as a membrane-associated precursor of 50 kDa and as a peripheral membrane monomeric polypeptide of 40 kDa that is easily removed by washing of cells with isotonic buffers and in the aqueous phase upon Triton p
- The eleventh international conference on AIDS: cautious celebration in Vancouver.
- J Clin Pharmacol. 1997 Jan;37(1):20-4. Unique Identifier : AIDSLINE MED/97200333
- Gibaldi M; Department of Pharmaceutics, School of Pharmacy, University of; Washington, Seattle 98195, USA.
- For the first time in the short but turbulent history of the International Conference on AIDS (acquired immune deficiency syndrome), participants found themselves in the midst of a sea change in the treatment of human immunodeficiency virus (HIV) disease. Scientists, health policy experts, politicians, and AIDS activi
- [Immunodeficiency and carcinogenesis in patients with chronic active Epstein-Barr virus infection]
- Kansenshogaku Zasshi. 1997 Jan;71(1):56-64. Unique Identifier : AIDSLINE MED/97206663
- Nagafuchi S; Fujisaki T; Ohshima K; Anzai K; Otsuka T; Kikuchi H; Nasu M; Kikuchi M; Sawae Y; Niho Y; First Department of Internal Medicine, Faculty of Medicine, Kyushu; University.
- Three adult patients with chronic active Epstein-Barr virus infection (CAEBV) had high anti-EBV-VCA antibody, positive anti-EA, low anti-EBNA and were associated with systemic lymphadenopathies and immunosuppression. The case 1 and 2 had elevated serum immunoglobulin levels, and recurrent infections, and case 3 showed
- [Clinical features of eight cases of opportunistic fungal pneumonias]
- Kansenshogaku Zasshi. 1997 Jan;71(1):65-71. Unique Identifier : AIDSLINE MED/97206664
- Urakami R; Nagasaka Y; Tohda Y; Ohishi M; Nakajima S; Fukuoka M; Fourth Department of Internal Medicine, Kinki University School of; Medicine, Osakasayama, Japan.
- We evaluated eight cases of pulmonary mycosis in immuno compromised hosts. The underlying diseases were lung cancer with chemotherapy in one case, post bone marrow transplantation (post BMT) in two cases, acquired immunodeficiency syndrome (AIDS) in one case and bronchial asthma with massive steroid therapy in four ca
- Mathematical modelling of the spread of HIV/AIDS amongst injecting drug users.
- IMA J Math Appl Med Biol. 1997 Mar;14(1):11-38. Unique Identifier : AIDSLINE MED/97235567
- Greenhalgh D; Hay G; Department of Statistics and Modelling Science, University of; Strathclyde, Glasgow, UK.
- In this paper we develop and analyse a model for the spread of HIV/AIDS amongst a population of injecting drug users. Our work is based on a model originally due to Kaplan (1989, Rev. Inf. Diseases 11, 289-98). We start off with a brief literature survey and review; this is followed up by a detailed description of Kap
- Neurodegeneration of somatostatin-immunoreactive neurons in HIV encephalitis.
- J Neuropathol Exp Neurol. 1997 Apr;56(4):360-8. Unique Identifier : AIDSLINE MED/97255319
- Fox L; Alford M; Achim C; Mallory M; Masliah E; University of California, San Diego, Department of Neurosciences, La; Jolla 92093-0624, USA.
- Recent studies have suggested that neuronal populations that contain glutamate receptors are vulnerable to damage mediated by the human immunodeficiency virus 1 (HIV-1). Somatostatin-immunoreactive neurons contain, among other elements, glutamate receptors, and might therefore be susceptible to HIV-mediated damage. In
- Clinical and neuropathological study of six patients with spastic paraparesis associated with HTLV-I: an axomyelinic degeneration of the central nervous system.
- J Neuropathol Exp Neurol. 1997 Apr;56(4):403-13. Unique Identifier : AIDSLINE MED/97255324
- Cartier LM; Cea JG; Vergara C; Araya F; Born P; Department of Neuroscience, Hospital del Salvador, Faculty of; Medicine, University of Chile, Santiago, Chile.
- Between 1990 to 1994, 6 TSP/HAM patients, 3 women and 3 men with an average age of 57.1 years (39 to 76 years old), who died in the Salvador Hospital were submitted to postmortem examination. The mean time of paraparesis was 7 years (3 to 17 years), and 2 patients had pseudobulbar signs. Three cases had macroscopic at
- Evaluation of two novel immunoassays designed to detect HIV antibodies in oral fluids.
- J Clin Lab Anal. 1997;11(1):63-8. Unique Identifier : AIDSLINE MED/97173627
- Saville RD; Constantine NT; Holm-Hansen C; Wisnom C; DePaola L; Falkler WA Jr; Department of Microbiology, University of Maryland School of; Dentistry, Baltimore, USA.
- The testing of oral fluid samples for the detection of HIV antibodies offers several advantages over the testing of blood. Our objective was to evaluate a new generation of rapid and simple assays designed specifically to detect HIV-1 and HIV-2 antibodies in oral fluids (saliva). Serum and oral fluid pairs were collec
- Quantitation of soluble E-receptor of T lymphocytes in serum from HIV-1 positive patients.
- J Clin Lab Anal. 1997;11(1):69-72. Unique Identifier : AIDSLINE MED/97173628
- Nunez G; Moura NC; Hernandez HJ; Peixinho ZF; Zeballos RS; Cavalcante N; Flores P; Longo IM; Mendes NF; Departamento de Microbiologia, Imunologia e Parasitologia-Disciplina; de Imunologia Escola Paulista de Medicina, Universidade Federal de Sao; paulo, Brasil.
- Human T lymphocytes carry a membrane receptor for sheep erythrocytes (E) related to the CD2 molecule. The E-receptor is found in a soluble from (Rs) in serum and can be quantitated by rocket electrophoresis using an anti-Rs serum obtained by immunizing sheep with autologous erythrocytes coated with Rs. Increased seru
- An immunohistochemical study of oral submucous fibrosis.
- J Oral Pathol Med. 1997 Feb;26(2):75-82. Unique Identifier : AIDSLINE MED/97202379
- Haque MF; Harris M; Meghji S; Speight PM; Department of Oral and Maxillofacial Surgery, Eastman Dental Institute; for Oral Health Care Sciences, University College London, UK.
- Oral submucous fibrosis (OSF) is a chronic disease of the oral cavity characterized by inflammation and progressive mucosal fibrosis. These reactions may be the result of either direct stimulation from exogenous antigens like areca alkaloids or by changes in tissue antigenicity that may lead to an autoimmune response.
- Cryptococcal infection in cats: factors influencing treatment outcome, and results of sequential serum antigen titers in 35 cats.
- J Vet Intern Med. 1997 Jan-Feb;11(1):1-4. Unique Identifier : AIDSLINE MED/97188629
- Jacobs GJ; Medleau L; Calvert C; Brown J; Department of Small Animal Medicine, College of Veterinary Medicine,; University of Georgia, Athens, USA.
- The relationship between treatment outcome and location of cryptococcal infection, gender, magnitude of pretreatment cryptococcal antigen titers, results of feline leukemia virus FeLV) and feline immunodeficiency virus (FIV) serology, and serial changes in antigen titers during and after treatment were evaluated in a
- IgA rheumatoid factor correlates with changes in B and T lymphocyte subsets and disease manifestations in rheumatoid arthritis.
- J Rheumatol. 1997 Feb;24(2):269-74. Unique Identifier : AIDSLINE MED/97187529
- Arinbjarnarson S; Jonsson T; Steinsson K; Sigfusson A; Jonsson H; Geirsson A; Thorsteinsson J; Valdimarsson H; Department of Immunology, National University Hospital, Reykjavik,; Iceland.
- OBJECTIVE: To analyze the relationship between lymphocyte subsets, different rheumatoid factor (RF) isotypes, and clinical features in patients with rheumatoid arthritis (RA). METHODS: Patients with established RA (n = 95) were examined clinically and blood samples were collected for measurements of RF by ELISA and fo
- The co-occurrence of acute rheumatic fever and AIDS.
- J Rheumatol. 1997 Feb;24(2):404-6. Unique Identifier : AIDSLINE MED/97187553
- Georgescu L; Riker C; Gibofsky A; Barland P; Department of Medicine, Hospital for Special Surgery-Cornell; University Medical Center, New York, USA.
- We describe a patient with advanced acquired immunodeficiency syndrome (AIDS) who presented with evidence of carditis, arthritis, and chorea in the setting of fever, and serologic evidence for recent streptococcal infection. Several features atypical for rheumatic fever were present and included persistently high tite
- Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring ring C).
- J Med Chem. 1997 Mar 14;40(6):1005-17. Unique Identifier : AIDSLINE MED/97236963
- Zembower DE; Liao S; Flavin MT; Xu ZQ; Stup TL; Buckheit RW Jr; Khilevich A; Mar AA; Sheinkman AK; MediChem Research, Inc., Lemont, Illinois 60439, USA.
- (+)-Calanolide A is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1), which was isolated from an extract of Calophyllum lanigerum, along with seven related compounds. In order to examine the structure-activity relationships of the trans-10,11-dimethyldihydropyran-12-ol ring
- Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.
- J Med Chem. 1997 Mar 14;40(6):885-97. Unique Identifier : AIDSLINE MED/97236949
- Hulten J; Bonham NM; Nillroth U; Hansson T; Zuccarello G; Bouzide A; Aqvist J; Classon B; Danielson UH; Karlen A; Kvarnstrom I; Samuelsson B; Hallberg A; Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical; Center, Uppsala University, Sweden.
- Ten C2-symmetric cyclic urea and sulfamide derivatives have been synthesized from L-mannonic gamma-lactone and D-mannitol. The results of experimental measurement of their inhibitory potencies against HIV-1 protease were compared to calculated free energies of binding derived from molecular dynamics (MD) simulations.
- Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
- J Med Chem. 1997 Mar 14;40(6):898-902. Unique Identifier : AIDSLINE MED/97236950
- Backbro K; Lowgren S; Osterlund K; Atepo J; Unge T; Hulten; Bonham NM; Schaal W; Karlen A; Hallberg A; Department of Molecular Biology, Uppsala University, Sweden.
- Two cyclic, C2-symmetric HIV-1 protease inhibitors , one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1 positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 A resolution. The struc
- HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
- J Med Chem. 1997 Mar 14;40(6):920-9. Unique Identifier : AIDSLINE MED/97236952
- Nicklaus MC; Neamati N; Hong H; Mazumder A; Sunder S; Chen J; Milne GW; Pommier Y; Laboratory of Medicinal Chemistry, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.
- Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester CAPE), a putative three-point pharmacophore for binding of inhibitors to IN was derived. This pharmacophore was used to search the National Cancer Institute three-dimensional (3D) structural data
- Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
- J Med Chem. 1997 Mar 14;40(6):930-6. Unique Identifier : AIDSLINE MED/97236953
- Hong H; Neamati N; Wang S; Nicklaus MC; Mazumder A; Zhao H; Burke TR Jr; Pommier Y; Milne GW; Laboratory of Medicinal Chemistry, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.
- Based upon a class of known HIV-1 integrase inhibitors, several pharmacophore models were proposed from molecular modeling studies and validated using a 3D database of 152, compounds for which integrase assay data are known. Using the most probable pharmacophore model as the query, the NCI 3D database of 206,876 compo
- Hydrazide-containing inhibitors of HIV-1 integrase.
- J Med Chem. 1997 Mar 14;40(6):937-41. Unique Identifier : AIDSLINE MED/97236954
- Zhao H; Neamati N; Sunder S; Hong H; Wang S; Milne GW; Pommier Y; Burke TR Jr; Laboratory of Medicinal Chemistry, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.
- Inhibitors of HIV integrase are currently being sought as potential new therapeutics for the treatment of AIDS. A large number of inhibitors discovered to date contain the o-bis-hydroxy catechol structure. In an effort to discover structural leads for the development of new HIV integrase inhibitors which do not rely o
- Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
- J Med Chem. 1997 Mar 14;40(6):942-51. Unique Identifier : AIDSLINE MED/97236955
- Neamati N; Hong H; Mazumder A; Wang S; Sunder S; Nicklaus MC; Milne GW; Proksa B; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Institute,; Bethesda, Maryland 20892-4255, USA.
- Seventeen lichen acids comprising despides, depsidones, and their synthetic derivatives have been examined for their inhibitory activity against HIV-1 integrase, and two pharmacophores associated with inhibition of this enzyme have been identified. A search of the NCI 3D database of approximately 200,000 structures yi
- Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.
- J Med Chem. 1997 Mar 28;40(7):1149-64. Unique Identifier : AIDSLINE MED/97244496
- Skulnick HI; Johnson PD; Aristoff PA; Morris JK; Lovasz KD; Howe WJ; Watenpaugh KD; Janakiraman MN; Anderson DJ; Reischer RJ; Schwartz TM; Banitt LS; Tomich PK; Lynn JC; Horng MM; Chong KT; Hinshaw RR; Dolak LA; Seest EP; Schwende FJ; Rush BD; Howard GM; Toth LN; Wilkinson KR; Romines KR; et al; Discovery Chemistry Research, Pharmacia and Upjohn, Kalamazoo,; Michigan 49001, USA.
- Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors , but these compounds lacked significant antiviral activity in cell culture. Substitution of a sulfonamide group at the m
- Occurrence and frequency of transmission of naturally occurring simian retroviral infections (SIV, STLV, and SRV) at the CIRMF Primate Center, Gabon.
- J Med Primatol. 1996 Oct;25(5):313-26. Unique Identifier : AIDSLINE MED/97181234
- Georges-Courbot MC; Moisson P; Leroy E; Pingard AM; Nerrienet E; Dubreuil G; Wickings EJ; Debels F; Bedjabaga I; Poaty-Mavoungou V; Hahn NT; Georges AJ; Centre International de Recherches Medicales (CIRMF), Franceville,; Gabon.
- Among the primates held at the CIRMF Primate Center, Gabon , no serological sign of SIV infection could be demonstrated in 68 cynomolgus monkeys, 60 chimpanzees, nine gorillas, and 12 sun-tailed monkeys, while seven of 102 mandrills and six of 24 vervets were infected with SIV. Six m
- A dynamic in vivo view of the HIV-I Rev-RRE interaction.
- J Mol Biol. 1997 Mar 14;266(5):950-62. Unique Identifier : AIDSLINE MED/97240813
- Charpentier B; Stutz F; Rosbash M; Department of Biology, Brandeis University, Waltham, MA 02254, USA.
- The export of pre-mRNAs coding for the structural genes of the human immunodeficiency virus type I depends on the interaction of the Rev protein with a highly structured viral RNA sequence, the Rev-responsive element (RRE). To gain information about the structure of the RRE and the determinants of the in vivo RRE-Rev
- Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization.
- J Virol. 1997 May;71(5):3397-406. Unique Identifier : AIDSLINE MED/97248381
- Laughrea M; Jette L; Mak J; Kleiman L; Liang C; Wainberg MA; McGill AIDS Centre, Lady Davis Institute for Medical Research, Sir; Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
- A stem-loop termed the kissing-loop hairpin is one of the most highly conserved structures within the leader of human immunodeficiency virus type 1 (HIV-1) and chimpanzee immunodeficiency virus genomic RNA. Because it plays a key role in the in vitro dimerization of short HIV-1 RNA transcripts (M. Laughrea and L. Jett
- Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation.
- J Virol. 1997 May;71(5):3407-14. Unique Identifier : AIDSLINE MED/97248382
- Clever JL; Parslow TG; Department of Pathology, University of California, San Francisco; 94143, USA.
- Retrovirus particles each contain two copies of the viral genome in the form of a noncovalently linked RNA dimer. Earlier studies have mapped a cis-acting region near the 5 end of the human immunodeficiency virus type 1 (HIV-1) genome, termed the psi locus, which appears essential for initiation of genomic dimerizati
- Transcriptional patterns of the pCD41 (U27) locus of human herpesvirus 6.
- J Virol. 1997 May;71(5):3420-30. Unique Identifier : AIDSLINE MED/97248384
- Zhou Y; Chandran B; Wood C; Department of Microbiology, University of Miami School of Medicine,; Florida 33101, USA.
- Human herpesvirus 6 (HHV-6) is a lymphotropic herpesvirus, and in vitro, it can productively infect many of the same cell types that human immunodeficiency virus (HIV) infects. Simultaneous infection of T cells by HIV and HHV-6 can lead to both activation of the HIV promoter and acceleration of the cytopathic effects.
- Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions.
- J Virol. 1997 May;71(5):3444-50. Unique Identifier : AIDSLINE MED/97248387
- Bastiani L; Laal S; Kim M; Zolla-Pazner S; Department of Pathology, NYU Medical Center, New York, New York 10016,; USA.
- In addition to gp41 and gp120, an array of cell adhesion molecules is present on the envelope of human immunodeficiency virus type 1 (HIV-1). To examine the role of the host cell in the acquisition of these molecules by virions, both laboratory-adapted and primary isolates were sequentially passaged into different hos
- Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17.
- J Virol. 1997 May;71(5):3474-83. Unique Identifier : AIDSLINE MED/97248391
- Cannon PM; Matthews S; Clark N; Byles ED; Iourin O; Hockley DJ; Kingsman SM; Kingsman AJ; Department of Biochemistry, University of Oxford, United Kingdom.
- The human immunodeficiency virus type 1 (HIV-1) matrix protein, p17, plays important roles in both the early and late stages of the viral life cycle. Using our previously determined solution structure of p17, we have undertaken a rational mutagenesis program aimed at mapping structure-function relationships within the
- The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins.
- J Virol. 1997 May;71(5):3484-97. Unique Identifier : AIDSLINE MED/97248392
- Bex F; McDowall A; Burny A; Gaynor R; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas 75235-8594/9072, USA. bex@utsw.swmed.edu
- The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transcription. Tax also activates the expression of specific cellular genes involved in the control of T-lymphocyte growth via effects on cellular transcription factors, including members of the NF-kappaB/cRel family. Immunoc
- Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower human female reproductive tract.
- J Virol. 1997 May;71(5):3498-506. Unique Identifier : AIDSLINE MED/97248393
- Howell AL; Edkins RD; Rier SE; Yeaman GR; Stern JE; Fanger MW; Wira CR; Department of Veterans Affairs, White River Junction, Vermont 05009,; USA. alexandra.howell@dartmouth.EDU
- Viable tissue sections and isolated cell cultures from the human fallopian tube, uterus, cervix, and vaginal mucosa were examined for susceptibility to infection with human immunodeficiency virus type 1 (HIV-1). We examined infectivity by using the monocytotropic strain HIV-1(JR-FL) and several primary isolates of HIV
- Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.
- J Virol. 1997 May;71(5):3507-14. Unique Identifier : AIDSLINE MED/97248394
- Engelman A; Liu Y; Chen H; Farzan M; Dyda F; Dana-Farber Cancer Institute and Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115, USA.
- Two different crystal structures of the human immunodeficiency virus type 1 (HIV-1) integrase (IN) catalytic domain were analyzed for interactions at the enzyme active site. Gln-62 and Glu-92 interact with active-site residue Asp-64, and Lys-136 interacts with active-site residue Asp-116 across a dimer interface. Cons
- Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.
- J Virol. 1997 May;71(5):3563-73. Unique Identifier : AIDSLINE MED/97248400
- Bassuk AG; Anandappa RT; Leiden JM; Department of Medicine, University of Chicago, Illinois 60637, USA.
- The transcriptional regulatory elements of many inducible T-cell genes contain adjacent or overlapping binding sites for the Ets and NF-kappaB/NFAT families of transcription factors. Similar arrays of functionally important NF-kappaB/NFAT and Ets binding sites are present in the transcriptional enhancers of human immu
- Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity.
- J Virol. 1997 May;71(5):3588-96. Unique Identifier : AIDSLINE MED/97248403
- Fortin JF; Cantin R; Lamontagne G; Tremblay M; Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire; de Quebec, Ste-Foy, Canada.
- Human immunodeficiency virus type 1 (HIV-1) acquires several host cell membrane proteins when it buds from infected cells. To study the effect of virally incorporated host-derived ICAM-1 glycoproteins on the biology of HIV-1, we have developed a transient expression system that has enabled us to produce virus particle
- Inflammatory cytokine expression is correlated with the level of human immunodeficiency virus (HIV) transcripts in HIV-infected placental trophoblastic cells.
- J Virol. 1997 May;71(5):3628-35. Unique Identifier : AIDSLINE MED/97248408
- Lee BN; Ordonez N; Popek EJ; Lu JG; Helfgott A; Eriksen N; Hammill H; Kozinetz C; Doyle M; Kline M; Langston C; Shearer WT; Reuben JM; Division of Laboratory Medicine, University of Texas M. D. Anderson; Cancer Center, Houston 77030, USA.
- The inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNF-alpha) have been associated with increased human immunodeficiency virus (HIV) expression and enhanced lymphocyte adhesion to trophoblastic cells in experimental systems. To determine if there is a correlation between th
- The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable.
- J Virol. 1997 May;71(5):3641-51. Unique Identifier : AIDSLINE MED/97248410
- Sinclair E; Barbosa P; Feinberg MB; Gladstone Institute of Virology and Immunology, San Francisco,; California 94141-100, USA.
- Adult rhesus macaques infected with nef-defective simian immunodeficiency virus (SIV) exhibit extremely low levels of steady-state virus replication, do not succumb to immunodeficiency disease, and are protected from experimental challenge with pathogenic isolates of SIV. Similarly, rare humans found to be infected wi
- Complete nucleotide sequence of simian endogenous type D retrovirus with intact genome organization: evidence for ancestry to simian retrovirus and baboon endogenous virus.
- J Virol. 1997 May;71(5):3666-76. Unique Identifier : AIDSLINE MED/97248412
- van der Kuyl AC; Mang R; Dekker JT; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre, Amsterdam,; The Netherlands. Kuyl@amc.uva.nl
- A complete endogenous type D viral genome has been isolated from a baboon genomic library. The provirus, simian endogenous retrovirus (SERV), is 8,393 nucleotides long and contains two long terminal repeats and complete genes for gag, pro, pol, and env. The primer binding site is complementary to tRNA(Lys)3, like in l
- The simian T-lymphotropic/leukemia virus from Pan paniscus belongs to the type 2 family and infects Asian macaques.
- J Virol. 1997 May;71(5):3684-92. Unique Identifier : AIDSLINE MED/97248414
- Digilio L; Giri A; Cho N; Slattery J; Markham P; Franchini G; Laboratory of Basic Research, National Cancer Institute, Bethesda,; Maryland 20892-4255, USA.
- The proviral DNA of the simian T-leukemia/lymphotropic virus STLV) isolate, originally obtained from a captive colony of pygmy chimpanzees (Pan paniscus) (STLV(pan-p)), was cloned from the DNA of the chronically infected human T-cell line L93-79B. The entire proviral DNA sequence was obtained and compared with sequenc
- A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells.
- J Virol. 1997 May;71(5):3693-701. Unique Identifier : AIDSLINE MED/97248415
- Moreno TN; Fortunato EA; Hsia K; Spector SA; Spector DH; Department of Biology, University of California, San Diego, La Jolla; 92093-0357, USA.
- Previously, our laboratory showed that human cytomegalovirus HCMV) activates human immunodeficiency virus type 1 (HIV-1) in brain-derived cells with limited HIV-1 gene expression but inhibits HIV-1 in cells fully permissive for replication of both viruses (F. M. Jault, S. A. Specto
- Modulation of murine AIDS-related pathology by concurrent antibody treatment and coinfection with Leishmania major.
- J Virol. 1997 May;71(5):3702-9. Unique Identifier : AIDSLINE MED/97248416
- Doherty TM; Giese N; Morse HC 3rd; Coffman RL; Laboratory of Parasitic Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892, USA.
- Infection of C57BL/6 mice with a mixture of murine leukemia viruses (MuLVs) designated LP-BM5 MuLV leads to a disease characterized by progressive immunodeficiency and lymphoproliferation, known as murine AIDS (MAIDS). The development of MAIDS is associated with increased B-cell lymphoblast proliferation, but there is
- Autologous and heterologous neutralizing antibody responses following initial seroconversion in human immunodeficiency virus type 1-infected individuals.
- J Virol. 1997 May;71(5):3734-41. Unique Identifier : AIDSLINE MED/97248420
- Moog C; Fleury HJ; Pellegrin I; Kirn A; Aubertin AM; INSERM U74, Institut de Virologie, Strasbourg, France.
- In the course of human immunodeficiency virus type 1 (HIV-1) infection, patients develop a strong and persistent immune response characterized by the production of HIV-specific antibodies. The aim of our study was to analyze the appearance of autologous and heterologous neutralizing antibodies in the sera of HIV-infec
- Induction of T-cell apoptosis by human herpesvirus 6.
- J Virol. 1997 May;71(5):3751-9. Unique Identifier : AIDSLINE MED/97248422
- Inoue Y; Yasukawa M; Fujita S; First Department of Internal Medicine, Ehime University School of; Medicine, Shigenobu, Japan.
- The mechanisms of cell death in CD4+ T cells mediated by human herpesvirus 6 (HHV-6) were investigated. The frequency of cell death in the human CD4+ T-cell line JJHAN, which had been inoculated with HHV-6 variant A or B, appeared to be augmented by tumor necrosis factor alpha (TNF-alpha). Agarose gel electrophoresis
- Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.
- J Virol. 1997 May;71(5):3776-87. Unique Identifier : AIDSLINE MED/97248425
- Page KA; van Schooten WC; Feinberg MB; Department of Microbiology and Immunology, University of; California-San Francisco 94141-9100, USA. page@wpo.sosc.osshe.edu
- We have developed an in vitro model to study the influence that human immunodeficiency virus type 1 (HIV-1) may have on the ability of T cells to respond to antigenic challenge. We have examined consequences of HIV-1 gene expression on T-cell activation in antigen-dependent T cells that have stably integrated copies o
- Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.
- J Virol. 1997 May;71(5):3872-8. Unique Identifier : AIDSLINE MED/97248435
- Sasadeusz JJ; Tufaro F; Safrin S; Schubert K; Hubinette MM; Cheung PK; Sacks SL; Department of Medicine, University of British Columbia, Vancouver,; Canada.
- In the majority of cases, the mechanism underlying the resistance to acyclovir (ACV) of herpes simplex viruses (HSVs) is thymidine kinase (TK) deficiency. Plaque isolates from eight ACV-resistant ACVr) clinical isolates from AIDS patients, of which five reactivated, were sequenc
- Assembled coronavirus from complementation of two defective interfering RNAs.
- J Virol. 1997 May;71(5):3922-31. Unique Identifier : AIDSLINE MED/97248441
- Kim KH; Narayanan K; Makino S; Department of Microbiology, The University of Texas at Austin, 78712,; USA.
- In the presence of an RNA- temperature-sensitive (ts) mutant helper virus, two coronavirus mouse hepatitis virus (MHV) defective interfering (DI) RNAs complemented each other, resulting in the assembly of MHV particles; we used this ability to complement as a means to study coronavirus assembly. One of the two DI RNAs
- Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection.
- J Virol. 1997 May;71(5):3932-9. Unique Identifier : AIDSLINE MED/97248442
- Chackerian B; Long EM; Luciw PA; Overbaugh J; Department of Microbiology, University of Washington, Seattle 98195,; USA.
- Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest
- Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.
- J Virol. 1997 May;71(5):3953-60. Unique Identifier : AIDSLINE MED/97248444
- Chen Z; Luckay A; Sodora DL; Telfer P; Reed P; Gettie A; Kanu JM; Sadek RF; Yee J; Ho DD; Zhang L; Marx PA; Aaron Diamond AIDS Research Center, Rockefeller University, New York,; New York 10016, USA.
- The extent of zoonotic infections in rural Sierra Leone , where both feral and pet sooty mangabeys harbor divergent members of the human immunodeficiency virus type 2 (HIV-2)-sooty mangabey simian immunodeficiency virus (SIVsm) family, was tested in blood samples collected from
- Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.
- J Virol. 1997 May;71(5):3961-71. Unique Identifier : AIDSLINE MED/97248445
- Poon B; Jowett JB; Stewart SA; Armstrong RW; Rishton GM; Chen IS; Department of Microbiology and Immunology, UCLA School of Medicine,; Los Angeles, California 90095, USA.
- The product of the human immunodeficiency virus type 1 (HIV-1) vpr gene induces cell cycle arrest in the G2 phase of the cell cycle and is characterized by an accumulation of the hyperphosphorylated form of cdc2 kinase. This phenotype is similar to the effect of DNA-damaging agents, which can also cause cells to arres
- Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: intravaginal and oral deposition of simian/human immunodeficiency virus in macaques results in systemic infection, elimination of CD4+ T cells, and AIDS.
- J Virol. 1997 May;71(5):4016-23. Unique Identifier : AIDSLINE MED/97248451
- Joag SV; Adany I; Li Z; Foresman L; Pinson DM; Wang C; Stephens EB; Raghavan R; Narayan O; Department of Microbiology, University of Kansas Medical Center,; Kansas City 66160-7424, USA.
- Chimeric simian/human immunodeficiency virus (SHIV) consists of the env, vpu, tat, and rev genes of human immunodeficiency virus type 1 (HIV-1) on a background of simian immunodeficiency virus SIV). We derived a SHIV that caused CD4+ cell loss and AIDS in pig-tailed macaques (S. V. Joag, Z. Li, L. Foresman, E. B. Step
- Endocytosis and recycling of varicella-zoster virus Fc receptor glycoprotein gE: internalization mediated by a YXXL motif in the cytoplasmic tail.
- J Virol. 1997 May;71(5):4042-54. Unique Identifier : AIDSLINE MED/97248454
- Olson JK; Grose C; Department of Microbiology and Immunology Program, University of Iowa; College of Medicine, Iowa City 52242, USA.
- Varicella-zoster virus (VZV) encodes a cell surface Fc receptor, glycoprotein gE. VZV gE has previously been shown to display several features common to nonviral cell surface receptors. Most recently, VZV gE was reported to be tyrosine phosphorylated on a dimeric form (J. K. Olson, G. A. Bishop, and C. Grose, J. Virol
- Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector.
- J Virol. 1997 May;71(5):4071-8. Unique Identifier : AIDSLINE MED/97248457
- Inouye RT; Du B; Boldt-Houle D; Ferrante A; Park IW; Hammer SM; Duan L; Groopman JE; Pomerantz RJ; Terwilliger EF; Division of Experimental Medicine, Beth Israel Deaconess Medical; Center and Harvard Institutes of Medicine, Boston, Massachusetts; 02215, USA.
- The rate of viral replication appears to play a pivotal role in human immunodeficiency virus type 1 (HIV-1) pathogenesis and disease progression as it outstrips the capacity of the immune system to respond. Important cellular sites for HIV-1 production include T lymphocytes and tissue macrophages. Antiviral strategies
- Stable human immunodeficiency virus type 1 (HIV-1) resistance in transformed CD4+ monocytic cells treated with multitargeting HIV-1 antisense sequences incorporated into U1 snRNA.
- J Virol. 1997 May;71(5):4079-85. Unique Identifier : AIDSLINE MED/97248458
- Liu D; Donegan J; Nuovo G; Mitra D; Laurence J; Enzo Biochem, Inc., Farmingdale, New York 11735, USA. dl@enzobio.com
- We have approached the development of a human immunodeficiency virus type 1 (HIV-1) therapeutic product by producing immune cells stably resistant to HIV-1. Promonocytic CD4+ cells (U937) were made resistant to HIV-1 by the introduction of a DNA construct (pNDU1A,B,C) that contained three independent antisense sequenc
- Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1.
- J Virol. 1997 May;71(5):4086-91. Unique Identifier : AIDSLINE MED/97248459
- Novembre FJ; Saucier M; Anderson DC; Klumpp SA; O'Neil SP; Brown CR 2nd; Hart CE; Guenthner PC; Swenson RB; McClure HM; Department of Pathology, Emory University, Atlanta, Georgia, USA.; fnovembr@rmy.emory.edu
- The condition of a chimpanzee (C499) infected with three different isolates of human immunodeficiency virus type 1 (HIV-1) for over 10 years progressed to AIDS. Disease development in this animal was characterized by (i) a decline in CD4+ cells over the last 3 years; (ii) an increase in viral loads in plasma; (iii) th
- Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat.
- J Virol. 1997 May;71(5):4098-102. Unique Identifier : AIDSLINE MED/97248461
- Li YP; Department of Medicine, Baylor College of Medicine, Houston, Texas; 77030, USA. yiping@tmc.bcm.edu
- Nucleolar shuttle protein B23 was found to bind to human immunodeficiency virus protein Tat, and this binding required the nucleolar localization motif of Tat. A fusion protein containing the B23 binding domain and beta-galactosidase caused mislocalization of Tat to the cytoplasm and inhibited the transactivation acti
- Defective herpes simplex virus type 1 vectors harboring gag, pol, and env genes can be used to rescue defective retrovirus vectors.
- J Virol. 1997 May;71(5):4111-7. Unique Identifier : AIDSLINE MED/97248464
- Savard N; Cosset FL; Epstein AL; Centre de Genetique Moleculaire et Cellulaire, UMR 5534 CNRS,; Universite Claude Bernard Lyon I, Villeurbanne, France.
- A retroviral packaging transcription unit was constructed in which the Moloney murine leukemia virus (MoMLV) gag-pol and env genes are expressed under the control of herpesvirus regulatory sequences. This transcription unit, lacking long terminal repeats, primer binding sites, and most of the retrovirus packaging sign
- Location of cis-acting signals important for RNA encapsidation in the leader sequence of human immunodeficiency virus type 2.
- J Virol. 1997 May;71(5):4133-7. Unique Identifier : AIDSLINE MED/97248468
- McCann EM; Lever AM; University of Cambridge Department of Medicine, Addenbrooke's; Hospital, United Kingdom.
- We used a series of deletion mutations in the untranslated leader region of human immunodeficiency virus type 2 (HIV-2) to seek cis-acting packaging signals. Sequences between the 5 major splice donor and the gag initiation codon, where such signals have been identified in HIV-1, appear to make a measurable but very
- Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species.
- J Virol. 1997 May;71(5):4138-44. Unique Identifier : AIDSLINE MED/97248469
- Rose TM; Strand KB; Schultz ER; Schaefer G; Rankin GW Jr; Thouless ME; Tsai CC; Bosch ML; Department of Pathobiology, School of Public Health and Community; Medicine, University of Washington, Seattle 98195, USA.; trose@u.washington.edu
- Simian retroperitoneal fibromatosis (RF) is a vascular fibroproliferative neoplasm which has many morphological and histological similarities to human Kaposi s sarcoma (KS). Like epidemic KS in AIDS patients, RF is highly associated with an immunodeficiency syndrome (simian acquired immunodeficiency syndrome [SAIDS])
- 55- and 75-kilodalton tumor necrosis factor receptors mediate distinct actions in regard to human immunodeficiency virus type 1 replication in primary human macrophages.
- J Virol. 1997 May;71(5):4150-6. Unique Identifier : AIDSLINE MED/97248471
- Herbein G; Gordon S; Virology Institute of the Faculty of Medicine and INSERM Unit 74,; Louis Pasteur University, Strasbourg, France.
- We report in this study that repeated tumor necrosis factor alpha TNF-alpha) pretreatment, starting before and continued after infection by human immunodeficiency virus type 1 (HIV-1), inhibits replication of the monocytotropic Ada strain in primary tissue culture-differentiated macrophages (TCDM), as assessed by sixf
- Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice.
- J Virol. 1997 May;71(5):4161-4. Unique Identifier : AIDSLINE MED/97248473
- Gulizia RJ; Collman RG; Levy JA; Trono D; Mosier DE; Department of Immunology-IMM7, The Scripps Research Institute, La; Jolla, California 92037, USA.
- The pathogenicity of four human immunodeficiency virus type 1 HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infec
- CD8+ T cells can mediate almost complete short-term and partial long-term immunity to rotavirus in mice.
- J Virol. 1997 May;71(5):4165-70. Unique Identifier : AIDSLINE MED/97248474
- Franco MA; Tin C; Greenberg HB; Veterans Administration Palo Alto Health Care System and Department of; Medicine, Stanford University School of Medicine, California 94305,; USA. francoma@leland.stanford.edu
- We have recently shown that CD8+ T cells mediate clearance of rotavirus infection in mice. B-cell-deficient J(H)D knockout mice depleted of CD8+ T cells become chronically infected with murine rotavirus, and beta2 microglobulin -/- and other mice depleted of CD8+ T cells have a 1- to 4-day delay in clearance of primar
- Protease inhibitors bring new social, clinical uncertainties to HIV care [news]
- JAMA. 1997 Apr 16;277(15):1182, 1184. Unique Identifier : AIDSLINE MED/97256487
- Voelker R
- Syringe and needle regulation, blood-borne disease transmission, and concern for public safety [letter]
- JAMA. 1997 Apr 16;277(15):1202-3; discussion 1203. Unique Identifier : AIDSLINE MED/97256500
- Friedland G
- Syringe and needle regulation, blood-borne disease transmission, and concern for public safety [letter; comment]
- JAMA. 1997 Apr 16;277(15):1203; discussion 1203. Unique Identifier : AIDSLINE MED/97256501
- Tsao K; Roaf EA
- [Clinical course of HIV-infected tuberculosis patients who admitted to the tuberculosis isolation ward: current problems of medical care]
- Kekkaku. 1997 Feb;72(2):67-72. Unique Identifier : AIDSLINE MED/97224704
- Fujita A; Suzuki A; Hamaoka T; Tojima H; Department of Pulmonary Medicine, Tokyo Metropolitan Fuchu Hospital,; Japan.
- To clarify the problems of medical care of HIV-infected tuberculosis patients, we investigated clinical course of six cases admitted to our tuberculosis isolation ward. All cases were sputum smear positive for tubercle bacilli at the time of diagnosis of tuberculosis. HIV-positive was confirmed at the same time or soo
- [A case of acquired immunodeficiency syndrome with disseminated Mycobacterium avium complex infection in which M. avium was isolated from bone marrow]
- Kekkaku. 1997 Feb;72(2):73-7. Unique Identifier : AIDSLINE MED/97224705
- Ohse H; Saito T; Kadono K; Hirano K; Watanabe S; Nemoto E; Fukai S; Yanai N; Ishii Y; Hasegawa S; National Seiranso Hospital, Ibaraki, Japan.
- A 46-year old man was admitted to a hospital because of cough and dyspnea. He was diagnosed as interstitial pneumonia and was treated with prednisolone (PSL) and antibiotics. The symptoms improved temporarily but he soon developed acute respiratory failure and was transferred to our hospital. Chest X-ray and CT reveal
- [Saprophytic and invasive pulmonary aspergillosis]
- Kekkaku. 1997 Feb;72(2):99-107. Unique Identifier : AIDSLINE MED/97224709
- Nagai H; Department of Pulmonary Diseases, Tokyo National Chest Hospital,; Japan.
- The characteristics of chest x-ray films in 19 patients with saprophytic pulmonary aspergillosis secondary to acid-fast bacilli infection were reported. The saprophytic form, exemplified by the classic fungus ball or mycetoma, results from the growth of fungal mycelia within a pre-existing area of destroyed lung, typi
- Dynamic multidrug therapies for HIV: a control theoretic approach.
- J Theor Biol. 1997 Mar 7;185(1):15-29. Unique Identifier : AIDSLINE MED/97247425
- Wein LM; Zenios SA; Nowak MA; Sloan School of Management, M.I.T., Cambridge, MA 02139, USA.
- Motivated by the inability of current drug treatment to provide long-term benefit to HIV-infected individuals, we derive HIV therapeutic strategies by formulating and analyzing a mathematical control problem. The model tracks the dynamics of uninfected and infected CD4+ cells and free plasma virus, and allows the viru
- 9-year HIV-2-associated mortality in an urban community in Bissau, west Africa.
- Lancet. 1997 Mar 29;349(9056):911-4. Unique Identifier : AIDSLINE MED/97247118
- Poulsen AG; Aaby P; Larsen O; Jensen H; Naucler A; Lisse IM; Christiansen CB; Dias F; Melbye M; Department of Epidemiology Research, Danish Epidemiology Science; Centre.
- BACKGROUND: Community studies with 1-3 years of follow-up have reported four to five times higher mortality in HIV-2-infected than in uninfected adults. In a cohort study of HIV-1, an increasing difference in mortality rates of HIV-1-infected and uninfected individuals is expected over time, because of rising mortalit
- 32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes [letter]
- Lancet. 1997 Mar 29;349(9056):922-3. Unique Identifier : AIDSLINE MED/97247123
- Rappaport J; Cho YY; Hendel H; Schwartz EJ; Schachter F; Zagury JF
- Severe hepatitis in three AIDS patients treated with indinavir [letter]
- Lancet. 1997 Mar 29;349(9056):924-5. Unique Identifier : AIDSLINE MED/97247126
- Brau N; Leaf HL; Wieczorek RL; Margolis DM
- Will Egypt escape the AIDS epidemic? [news]
- Lancet. 1997 Apr 5;349(9057):1005. Unique Identifier : AIDSLINE MED/97255290
- Lenton C
- Personal screening for HIV revisited [letter; comment]
- Lancet. 1997 Apr 5;349(9057):1032. Unique Identifier : AIDSLINE MED/97255315
- Frerichs RR
- Restoration of immunity to chronic hepatitis B infection in HIV-infected patient on protease inhibitor [letter]
- Lancet. 1997 Apr 5;349(9057):995-6. Unique Identifier : AIDSLINE MED/97255282
- Carr A; Cooper DA
- HTLV-I provirus in seronegative healthy blood donors [letter]
- Lancet. 1997 Apr 5;349(9057):999. Unique Identifier : AIDSLINE MED/97255286
- Zucker-Franklin D; Gorman JG
- Emerging international consensus for use of antiretroviral therapy [see comments]
- Lancet. 1997 Apr 12;349(9058):1042. Unique Identifier : AIDSLINE MED/97261286
- Montaner JS; Hogg RS; O'Shaughnessy MV; Centre for Excellence on HIV/AIDS, Canadian HIV Trials Network; St; Paul's Hospital/University of British Columbia, Vancouver, Canada.
- Late postnatal mother-to-child transmission of HIV-1 in Abidjan, Cote d'Ivoire.
- Lancet. 1997 Apr 12;349(9058):1054-9. Unique Identifier : AIDSLINE MED/97261289
- Ekpini ER; Wiktor SZ; Satten GA; Adjorlolo-Johnson GT; Sibailly TS; Ou CY; Karon JM; Brattegaard K; Whitaker JP; Gnaore E; De Cock KM; Greenberg AE; Project RETRO-CI, Abidjan, Cote d'Ivoire.
- BACKGROUND: HIV-1 can be transmitted from an infected mother to her infant through breastfeeding, although the precise risk of transmission by this route is unknown. A long-term follow-up of children born to HIV-infected women in Abidjan, Cote d Ivoire , has enabled us to estim
- Nonoxynol-9 fails to protect against HIV-1 [news]
- Lancet. 1997 Apr 12;349(9058):1074. Unique Identifier : AIDSLINE MED/97261300
- Rowe PM
- Chemokines join fight against HIV-1 infection [news]
- Lancet. 1997 Apr 12;349(9058):1075. Unique Identifier : AIDSLINE MED/97261301
- Morris K
- US Congress examines new approach to HIV [news]
- Lancet. 1997 Apr 12;349(9058):1078. Unique Identifier : AIDSLINE MED/97261302
- Rovner J
- Israeli ministries delay implementation of requirement to reveal HIV status [news]
- Lancet. 1997 Apr 12;349(9058):1080. Unique Identifier : AIDSLINE MED/97261303
- Fishman RH
- British HIV Association guidelines for antiretroviral treatment of HIV seropositive individuals. BHIVA Guidelines Co-ordinating Committee [see comments]
- Lancet. 1997 Apr 12;349(9058):1086-92. Unique Identifier : AIDSLINE MED/97261305
- Only incomplete data are available to guide decision on anti-HIV treatment. A British HIV Association consensus is that guidance must draw on other evidence besides the randomised trial. Marker studies, work on disease pathogenesis and viral dynamics, and expanding knowledge of resistance patterns mean that the approa
- Cryptosporidiosis in Houston, Texas. A report of 95 cases.
- Medicine (Baltimore). 1997 Mar;76(2):118-39. Unique Identifier : AIDSLINE MED/97255392
- Hashmey R; Smith NH; Cron S; Graviss EA; Chappell CL; White AC Jr; Department of Medicine, Baylor College of Medicine, Ben Taub General; Hospital, Houston, TX 77030, USA.
- Cryptosporidiosis is an important cause of diarrhea. We identified 95 patients with cryptosporidiosis over a 6-year period in our county hospital system, including 9 children and 86 adults infected with the human immunodeficiency virus (HIV). Risk factors included male-to-male sexual practices and Hispanic race. Diarr
- Caring for persons with AIDS in greater Minnesota.
- Minn Med. 1997 Feb;80(2):43-5. Unique Identifier : AIDSLINE MED/97202897
- Chial H; Elliott BA; University of Minnesota Medical School, USA.
- This study identifies ways in which physicians in rural and nonurban settings can better meet the needs of caregivers for persons with HIV/AIDS. We interviewed 14 caregivers living in these settings and documented their experiences and needs. Caregivers indicated that physicians had been providing needed medical care,
- Screening pregnant women for HIV.
- Minn Med. 1997 Feb;80(2):48-50. Unique Identifier : AIDSLINE MED/97202898
- Lupo VR; Department of Obstetrics and Gynecology, University of Minnesota, USA.
- Identification of HIV-1 group O infection--Los Angeles county, California, 1996.
- MMWR Morb Mortal Wkly Rep. 1996 Jul 5;45(26):561-5. Unique Identifier : AIDSLINE MED/97265487
- The strains of HIV-1 that have caused the worldwide pandemic of acquired immunodeficiency syndrome (AIDS) have been designated as group M viruses. A group of HIV-1 viruses that also cause AIDS but that are characterized by extensive genetic divergence from group M strains have been identified recently and classified a
- Surveillance for penicillin-nonsusceptible Streptococcus pneumoniae--New York City, 1995.
- MMWR Morb Mortal Wkly Rep. 1997 Apr 11;46(14):297-9. Unique Identifier : AIDSLINE MED/97268930
- Streptococcus pneumoniae has become a leading cause of bacteremia, pneumonia, meningitis, and otitis media in the United States . Persons at increased risk include young children, immunocompromised persons, and the elderly. Until 1987, S. pneumoniae was uniformly susceptible to penicill
- AIDS rates.
- MMWR Morb Mortal Wkly Rep. 1997 Apr 18;46(15):333-4. Unique Identifier : AIDSLINE MED/97268929
- The following map provides the annual rates of acquired immunodeficiency syndrome (AIDS) per 100,000 population, by state of residence from January through December 1996. The accompanying table lists the metropolitan areas with the 50 highest annual rates of AIDS per 100,000 population.
- Thymidine in the micromolar range promotes rejoining of UVC-induced DNA strand breaks and prevents azidothymidine from inhibiting the rejoining in quiescent human lymphocytes.
- Mutat Res. 1997 Mar 12;383(2):143-53. Unique Identifier : AIDSLINE MED/97243483
- Munch-Petersen B; Department of Life Sciences and Chemistry, Roskilde University,; Denmark. bmp@virgil.ruc.dk
- The effect and inter-individual variation in the effect of exogenously added deoxynucleosides (2 x 10(-6) M) on rejoining of UVC-induced DNA strand breaks was examined in quiescent human lymphocytes from 25 healthy persons. Thymidine at concentrations below 2 x 10(-6) M, effectively and with statistically extreme sign
- Taste and smell. Neglected senses that contribute to the malnutrition of AIDS.
- N C Med J. 1997 Mar-Apr;58(2):100-4. Unique Identifier : AIDSLINE MED/97243219
- Heald AE; Schiffman SS; Division of Infectious Diseases, Duke University Medical Center,; Durham 27710, USA.
- Taste and smell loss (due to medications, oral pathology such as candidiasis, and peripheral or central nervous system disease) are well documented in HIV-infected people. These chemosensory abnormalities can impair food intake and contribute to wasting. An understanding of the how medications affect the senses of tas
- Brain biopsy for HIV-infected patients with intracranial lesions.
- N C Med J. 1997 Mar-Apr;58(2):106-9. Unique Identifier : AIDSLINE MED/97243220
- Heald AE; Division of Infectious Diseases, Duke University Medical Center,; Durham 27710, USA.
- Remembering Ron. A glimpse into the heart of doctoring.
- N C Med J. 1997 Mar-Apr;58(2):110-2. Unique Identifier : AIDSLINE MED/97243221
- Porter WG; Department of Medicine, Carolinas Medical Center, Charlotte 28232,; USA.
- Primary medical care of the gay or lesbian patient.
- N C Med J. 1997 Mar-Apr;58(2):92-6. Unique Identifier : AIDSLINE MED/97243217
- Rankow EJ; Duke's Comprehensive Cancer Center, DUMC, Durham 27710, USA.
- gp120, a human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats.
- Neuroscience. 1997 Jan;76(2):397-409. Unique Identifier : AIDSLINE MED/97167707
- Barks JD; Liu XH; Sun R; Silverstein FS; Department of Pediatrics, University of Michigan, Ann Arbor; 48109-0646, USA.
- Recent data suggest that gp120, a human immunodeficiency virus-1 HIV-1) coat glycoprotein that is secreted by HIV-infected cells, is neurotoxic, and that this toxicity is mediated, at least in part, by activation of N-methyl-D-aspartate-type excitatory amino acid receptors. To test this hypothesis in vivo, we examined
- Haemolytic-uraemic syndrome in a patient infected by HIV [letter]
- Nephrol Dial Transplant. 1997 Feb;12(2):362-3. Unique Identifier : AIDSLINE MED/97206194
- Benitez M; Boto A; Colchero J; Fernandez-Giron F; Rodriguez P; Paralle M; Pujol E
- Consequences, cultural factors, detection, and prevention of HIV/AIDS in sub-Saharan Africa [editorial]
- Obstet Gynecol Surv. 1997 Jan;52(1):1-3. Unique Identifier : AIDSLINE MED/97147332
- Verkuyl DA
- Anogenital papillomavirus infection and neoplasia in immunodeficient women.
- Obstet Gynecol Clin North Am. 1996 Dec;23(4):861-93. Unique Identifier : AIDSLINE MED/97143768
- Wright TC Jr; Sun XW; Department of Pathology, College of Physicians and Surgeons of; Columbia University, New York, New York, USA.
- This article reviews the impact of infection with human immunodeficiency virus (HIV) on HPV infections and HPV-associated lesions of the female anogenital tract. Studies investigating HPV infections in HIV-seropositive women are presented as well as the possibility that HIV can influence HPV expression directly throug
- HPV infection and disease in men.
- Obstet Gynecol Clin North Am. 1996 Dec;23(4):895-916. Unique Identifier : AIDSLINE MED/97143769
- Palefsky JM; Barrasso R; Department of Laboratory Medicine, University of California, San; Francisco, USA.
- Penile HPV infection and disease are very common in sexually active men, and may be manifest in many forms. Treatment of clinically detectable lesions is advisable not only to relieve symptoms but also to prevent the spread of HPV infection to new sexual partners. Treatment of subclinical disease is more controversial
- Sicca syndrome in patients infected with the human immunodeficiency virus [published erratum appears in Ophthalmology 1996 Feb;103(2):204]
- Ophthalmology. 1995 Sep;102(9):1319-24. Unique Identifier : AIDSLINE MED/97252229
- Geier SA; Libera S; Klauss V; Goebel FD; Augenklinik im Universitatsklinikum Rudolf Virchow, Alexander von; Humboldt Universitat zu Berlin, Germany.
- PURPOSE: To investigate an association of the severity of the human immunodeficiency virus (HIV) disease with decreased tear production in a controlled setting. PATIENTS AND METHODS: Seventy-two patients (