Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
Correlation of in-hospital mortality with CD4 count and acute physiology score in hospitalized patients with HIV infection.
Int Conf AIDS. 1996 Jul 7-12;11(1):115 (abstract no. Mo.B.1346). Unique Identifier : AIDSLINE MED/96921410 Afessa B; University Medical Center, University of Florida Health Science; Center, Jacksonville, FL, USA. Fax: 904-549-5090.
Abstract:
Objective: The Acute Physiology and Chronic Health Evaluation APACHE) II system is used to predict the outcome of patients admitted to intensive care units. The acute physiology score APS) is a component of the APACHE II and is based on vital signs, Glasgow coma score and selected laboratory values. We undertook this study to determine the correlation of in-hospital mortality with CD4 lymphocyte count and APS of hospitalized, HIV-infected patients. Methods: Two hundred and twenty-three patients with HIV infection hospitalized in the 9-month period between 1 April and 31 December, 1995 were included in this prospective, observational study. Data collected included age, sex, race, risk factor for HIV infection, the presence of AIDS and the CD4 count during or within 6 months prior to hospitalization. The APS was calculated from the worst vital sign, Glasgow coma score and selected laboratory values obtained within 24 hours of hospital admission. In hospital mortality was noted. Student's t, Mann-Whitney U, chi square and Fisher's exact tests were used for statistical comparisons between groups. P values less than .05 were considered significant. Results: Sixty-eight percent (151/223) of the subjects were male; 83% 185) were African American, 17% (37) were Caucasian and 1 was Hispanic. The main known risk factors for HIV infection were injection drug use (92) and homosexuality (39). Subjects' mean plus or minus SD) age was 37.7 plus or minus 9.5 years. Two hundred of the subjects had known AIDS indicator conditions. The in-hospital mortality of the study subjects was 9% (20/223). There was no significant difference in age, race and sex between survivors and non-survivors. The median CD4 count of survivors was 40/microliter compared vs 20/microliter of non-survivors p=.3179). The median APS of survivors was 9 compared to 20.5 of non-survivors (p is less than .0001). Conclusion: Although the CD4 count is a strong predictor of long term survival, the acute physiology score correlates better with in-hospital mortality of hospitalized patients with HIV infection.
Keywords: *CD4 Lymphocyte Count *HIV Infections/MORTALITY 970130
M9715862
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
