High frequencies of human T-lymphotropic virus type I (HTLV-I) infection and presence of HTLV-II proviral DNA in blood donors with anti-thyroid antibodies.

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High frequencies of human T-lymphotropic virus type I (HTLV-I) infection and presence of HTLV-II proviral DNA in blood donors with anti-thyroid antibodies.

J Mol Med. 1996 Aug;74(8):471-7. Unique Identifier : AIDSLINE MED/97026683
Mine H; Kawai H; Yokoi K; Akaike M; Saito S; First Department of Internal Medicine, School of Medicine,; University of Tokushima, Japan.

Abstract: To investigate the relationship between human T-lymphotropic virus (HTLV) types I and II and the pathogenesis of autoimmune thyroid diseases, we examined serum anti-thyroid antibodies in 1019 blood donors with or without serum anti-HTLV-I antibody as well as proviral DNA for HTLV-II in leukocyte DNA by the polymerase chain reaction in 395 blood donors with or without anti-thyroid antibodies. The frequency of donors with anti-HTLV-I antibody who also showed anti-thyroid antibodies (7.9%) tended to be higher than that (6.3%) among donors who did not have the anti-HTLV-I antibody. The frequency of anti-thyroid antibodies in 125 young male donors aged 16-39 years with anti-HTLV-I antibody (4.8%) was significantly higher (P < 0.05) than that (0.6%) in 164 control donors without the antibody. In blood donors with anti-thyroid antibody, 25.0% of those with anti-HTLV-I antibody and 14.3% of those without the antibody had HTLV-II proviral DNA. In contrast, in donors without anti-thyroid antibody HTLV-II proviral DNA was detected in 2.3% of those with anti-HTLV-I antibody and in 0.6% of those without the antibody. Thus the detection rates in donors with anti-thyroid antibody were significantly higher (P < 0.001) than those in donors without the antibody, regardless of HTLV-I infection. These results suggest that HTLV-I infection and the presence of HTLV-II proviral DNA may be independently related to the pathogenesis of autoimmune thyroid diseases.

Keywords: Adolescence Adult Aged Antibodies/*BLOOD Blood Donors/STATISTICS & NUMER DATA DNA Primers DNA, Viral/ANALYSIS/BLOOD Electrophoresis, Polyacrylamide Gel Female Genes, pol/GENETICS Genes, pX/GENETICS Human HTLV-I/*IMMUNOLOGY/METABOLISM HTLV-II/*IMMUNOLOGY/METABOLISM Japan Leukocytes/CHEMISTRY Male Middle Age Polymerase Chain Reaction Proviruses/GENETICS Retroviridae/GENETICS/IMMUNOLOGY Serology Support, Non-U.S. Gov't Thyroid Gland/*IMMUNOLOGY JOURNAL ARTICLE
970228
M9721929

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