Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome.

Clin Immunol Immunopathol. 1996 Nov;81(2):129-35. Unique Identifier : AIDSLINE MED/97064124
Kawabata K; Nagasawa M; Morio T; Okawa H; Yata J; Department of Pediatrics, School of Medicine, Tokyo Medical and; Dental University, Japan.

Abstract: Cell surface CD8 molecules exist as either alpha/alpha homodimers or alpha/beta heterodimers, and most CD8+ T cells that undergo differentiation in the thymus express alpha/beta heterodimers. CD8 molecules on peripheral blood lymphocytes of patients with Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency disease, have now been shown to be composed mostly of alpha/alpha homodimers, while the total number of lymphocytes was maintained. This observation may indicate aberrant differentiation of CD8+ T cells in the thymus of WAS. Decreased CD8alpha/beta heterodimer expression, and the relative increase of CD8+ T cells expressing CD8alpha/alpha homodimer, may explain a part of the defective lymphocyte functions in WAS patients.
Keywords: Aging/PHYSIOLOGY Antigens, CD3/ANALYSIS CD8-Positive T-Lymphocytes/CHEMISTRY/*CYTOLOGY Flow Cytometry/METHODS Human Immunoglobulins/BLOOD Infant Killer Cells, Natural/CYTOLOGY Lymphocyte Count Receptors, Antigen, T-Cell, alpha-beta/ANALYSIS Wiskott-Aldrich Syndrome/BLOOD/IMMUNOLOGY/*PATHOLOGY JOURNAL ARTICLEKWDaging/physiologyantigens,cd3/analysiscd8-positivet-lymphocytes/chemistry/KWDcytologyflowcytometry/methodshumanimmunoglobulins/bloodinfantkillercells,natural/cytologylymphocytecountreceptors,antigen,t-cell,alpha-beta/analysiswiskott-aldrichsyndrome/blood/immunology/KWDpathologyjournalarticle
970228
M9721897

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