HIV disease in children is associated with a selective decrease in CD23+ and CD62L+ B cells. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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HIV disease in children is associated with a selective decrease in CD23+ and CD62L+ B cells.

Clin Immunol Immunopathol. 1996 Nov;81(2):191-9. Unique Identifier : AIDSLINE MED/97064132
Rodriguez C; Thomas JK; O'Rourke S; Stiehm ER; Plaeger S; Department of Pediatrics, UCLA School of Medicine, Los Angeles,; California 90095, USA.

Abstract: We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude that, despite persistent high immunoglobulin levels, total B cells decreased as HIV disease progressed, with selective decreases in CD62L+ and CD23+ B cells. This resulted in an increased proportion of usually minor subpopulations of CD62L- and CD23-negative B cells. We did not find significantly altered B cell expression of other activation/immaturity antigens. This suggests an absolute decrease in a subset of antigen-responsive B cells and a disproportionate increase in a subset of hyperstimulated B cells. These findings provide a biological basis for the paradoxical generalized B cell hyperactivity and specific immune unresponsiveness that are characteristic of HIV infection in children.
Keywords: Antigens, CD/GENETICS Antigens, CD19/ANALYSIS Antigens, Differentiation, B-Lymphocyte/GENETICS B-Lymphocyte Subsets/IMMUNOLOGY B-Lymphocytes/*IMMUNOLOGY Child Child, Preschool Female Human Hypergammaglobulinemia/IMMUNOLOGY HIV Infections/*BLOOD Infant L-Selectin/ANALYSIS Lymphocyte Count Male Neprilysin/GENETICS Phenotype Receptors, IgE/ANALYSIS Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDantigens,cd/geneticsantigens,cd19/analysisantigens,differentiation,b-lymphocyte/geneticsb-lymphocytesubsets/immunologyb-lymphocytes/KWDimmunologychildchild,preschoolfemalehumanhypergammaglobulinemia/immunologyhivinfections/KWDbloodinfantl-selectin/analysislymphocytecountmaleneprilysin/geneticsphenotypereceptors,ige/analysissupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
970228
M9721895

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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