Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis.
J Immunol. 1996 Dec 1;157(11):5170-7. Unique Identifier : AIDSLINE MED/97098752 Arai K; Yamamura S; Hanyu T; Takahashi HE; Umezu H; Watanabe H; Abo T; Department of Immunology, Niigata University School of Medicine,; Japan.
Abstract:
Murine collagen-induced arthritis (CIA) is known as a T cell-mediated autoimmune disease, although autoantibodies are also suspected to be associated with the onset of the disease. To determine the origin of such T cells in the joints of mice with CIA, their phenotypic properties as well as those of T cells in other immune organs were examined in DBA/1 mice. Since a significant number of mononuclear cells (MNC) was also yielded by the joints of normal DBA/1 mice, the properties of these T cells were examined in parallel. When CIA was induced by an intradermal injection of type II collagen at the base of the tail, the numbers of MNC yielded by the regional lymph nodes and the foot joints were doubled. Interestingly, regardless of the onset of CIA, the joints were always comprised of unique T cell populations, including IL-2(R)alpha- beta+ T cells, gammadelta T cells, CD8alpha+ beta- cells, and CD44+ L-selectin- cells. All these properties coincide with those of extrathymic T cells in liver and intestine. In the case of gammadelta T cells in joints, Vgamma and Vdelta usages were unique and different from those in the other organs. More importantly, Vgamma and Vdelta usages in gammadelta T cells in the joints of normal mice and in those of mice with CIA were essentially the same. Taken together with the expression of recombination-activating gene-1 and -2 mRNAs by MNC in mice with CIA, these findings raise the possibility that the joints have their own resident T cells that are extrathymically generated in situ.
Keywords: Animal Arthritis/ETIOLOGY/*IMMUNOLOGY/*PATHOLOGY Autoimmune Diseases/ETIOLOGY/IMMUNOLOGY/PATHOLOGY Base Sequence Bone Marrow/IMMUNOLOGY/PATHOLOGY Cell Adhesion Molecules/METABOLISM Cell Differentiation Collagen/*IMMUNOLOGY Comparative Study CD8-Positive T-Lymphocytes/IMMUNOLOGY/PATHOLOGY Disease Models, Animal DNA Primers/GENETICS Gene Expression Joints/IMMUNOLOGY/METABOLISM/PATHOLOGY Male Mice Mice, Inbred DBA Phenotype Proteins/GENETICS Support, Non-U.S. Gov't T-Lymphocytes/*IMMUNOLOGY/METABOLISM/*PATHOLOGY JOURNAL ARTICLE 970228
M9721851
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Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
