CD4 deficiency in myelodysplastic syndrome with monosomy 7. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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CD4 deficiency in myelodysplastic syndrome with monosomy 7.

Eur J Pediatr. 1996 Feb;155(2):96-8. Unique Identifier : AIDSLINE MED/96371386
Weemaes CM; Preijers F; de Vaan GA; Bakkeren JA; Klasen IS; Haraldsson A; Department of Paediatrics, University Hospital Nijmegen,; Netherlands.

Abstract: We describe a patient with myelodysplastic syndrome with monosomy 7 presenting with a T-cell defect. He suffered from infections from the age of 10 years, when a CD4 deficiency and impaired lymphoproliferative responses in vitro were found. The only symptom of a myelodysplastic syndrome at that time was thrombocytopenia with giant platelets. Monosomy 7 was found in the bone marrow cells. At the age of 11 years he developed other characteristics of monosomy 7 including splenomegaly and anaemia. Some months later leukaemia was diagnosed. CONCLUSION: In non-HIV CD4 deficiency myelodysplastic syndrome has to be considered.
Keywords: Antigens, CD4/*BLOOD Case Report Child *Chromosomes, Human, Pair 7 Human Immunophenotyping Male *Monosomy Myelodysplastic Syndromes/*GENETICS/*IMMUNOLOGY JOURNAL ARTICLEKWDantigens,cd4/KWDbloodcasereportchildKWDchromosomes,human,pair7humanimmunophenotypingmaleKWDmonosomymyelodysplasticsyndromes/KWDgenetics/KWDimmunologyjournalarticle
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M9720992

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