1997

Molecular epidemiology of Encephalitozoon cuniculi and first detection of Enterocytozoon bieneusi in faecal samples of pigs.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):93S. Unique Identifier : AIDSLINE GENBANK/U61180; Deplazes P; Mathis A; Muller C; Weber R; Institute of Parasitology, Univ. of Zurich, Switzerland.
Retesting of sera for antibodies to HIV-1/HIV-2.: Commun Dis Rep CDR Wkly. 1996 May 3;6(18):153. Unique Identifier : AIDSLINE MED/97089510
HIV infection and AIDS in the United States.: Commun Dis Rep CDR Wkly. 1996 May 3;6(18):153, 156. Unique Identifier : AIDSLINE MED/97089511
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1996 Oct 18;6(42):371-4. Unique Identifier : AIDSLINE MED/97091053
Romanian adoption. The Manitoba experience.: Arch Pediatr Adolesc Med. 1996 Dec;150(12):1278-82. Unique Identifier : AIDSLINE MED/97112311; Benoit TC; Jocelyn LJ; Moddemann DM; Embree JE; Department of Pediatrics and Child Health, Children's Hospital,; Health Sciences Centre, Winnipeg, Manitoba.; OBJECTIVE: To study the developmental, behavioral, and medical features in a cohort of Romanian children adopted by Manitoba families. DESIGN: A prospective longitudinal study. SETTING: The Child Development Clinic, Children s Hospital, Winnipeg, Manitoba, from September 1990 to June 1992. PATIENTS: Developmental, beh
Evolving ethical issues in selection of subjects for clinical research.: Camb Q Healthc Ethics. 1996 Summer;5(3):334-45. Unique Identifier : AIDSLINE MED/97016184; Weijer C; Clinical Trials Research Group, McGill University, Montreal,; Canada.
For her own good: protecting (and neglecting) women in research.: Camb Q Healthc Ethics. 1996 Summer;5(3):346-61. Unique Identifier : AIDSLINE MED/97016185; Shuster E; Department of Psychiatry, University of Pennsylvania,; Philadelphia, USA.
Patient access to experimental drugs and AIDS clinical trial designs: ethical issues.: Camb Q Healthc Ethics. 1996 Summer;5(3):400-9. Unique Identifier : AIDSLINE MED/97016189; Schuklenk U; Hogan C; Monash University Centre for Human Bioethics, Australia.
HIV-related parotid lymphoepithelial cysts. Immunohistochemistry and 3-D reconstruction of surgical and autopsy material with special reference to formal pathogenesis.: Virchows Arch. 1996 Oct;429(2-3):139-47. Unique Identifier : AIDSLINE MED/97075324; Ihrler S; Zietz C; Riederer A; Diebold J; Lohrs U; Institute of Pathology, Ludwig Maximilians University, Munchen,; Germany.; Whether lymphoepithelial cysts in the parotid glands in HIV-infected patients develop from pre-existing salivary gland inclusions in intraparotid lymph nodes or from a lymphoepithelial lesion of salivary parenchyma is unclear. To examine their pathogenesis we performed a histological and immunohistochemical study of s
Chronic rejection of concordant aortic xenografts in the hamster-to-rat model.: Transpl Immunol. 1996 Sep;4(3):192-7. Unique Identifier : AIDSLINE MED/97048617; Scheringa M; Buchner B; de Bruin RW; Geerling RA; Melief MJ; Mulder AH; Schraa EO; Ijzermans JN; Marquet RL; Department of Surgery, Leiden University Hospital, The; Netherlands.; Several groups have demonstrated that it is possible to obtain long-term graft survival of concordant xenografts. One of the important questions that remains is whether xenografts are susceptible to chronic rejection. To answer this question we used the aorta transplantation model. One centimetre of hamster aorta was
Xenogeneic iso-skin graft and mixed lymphocyte reaction studies using HLA-DP transgenic mice.: Transpl Immunol. 1996 Sep;4(3):220-6. Unique Identifier : AIDSLINE MED/97048622; Hagihara M; Shimura T; Takebe K; Munkhbat B; Sato T; Tsuchida F; Sato K; Tsuji K; Department of Transplantation Immunology, Tokai University School; of Medicine, Kanagawa, Japan.; To elucidate the cellular responses against xeno-MHC antigens, in vitro mixed lymphocyte culture (MLC) and in vivo skin grafting (SG) studies were conducted using HLA-DP transgenic mice (B6-DP mice). Xenogenic iso-(B6-DP to B6 mice) MLC showed positive but much lower responses compared to allo-MLC responses. Neverthel
[Expanded serologic infection testing of autologous blood donors: a report of experiences]: Beitr Infusionsther Transfusionsmed. 1996;33:196-200. Unique Identifier : AIDSLINE MED/97019457; Zimmermann R; Weisbach V; Wittmann G; Zingsem J; Neidhardt B; Eckstein R; Abteilung fur Transfusionsmedizin und Hamostaseologie,; Friedrich-Alexander-Universitat Erlangen-Nurnberg, Deutschland.; PURPOSE: The transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV-1/2) may cause serious disease in the recipient in cases of inadvertant homologous transfusion of autologous blood. Therefore data on the incidence of these infections in autologous blood donors are nece
[Nanofiltration in production of Beriplex P/N: increasing the capacity of virus elimination while maintaining product quality]: Beitr Infusionsther Transfusionsmed. 1996;33:220-4. Unique Identifier : AIDSLINE MED/97019462; Romisch J; Groner A; Bernhardt D; Diehl KH; Hein B; List W; Muller HG; Nowak T; Ronneberger H; Schuler E; Weimer T; Hilfenhaus J; Centeon Pharma GmbH, Marburg/Lahn, Deutschland.; For the manufacture of the PCC Beriplex P/N, nanofiltration was introduced into the production process of Beriplex HS providing an additional means to heat treatment for the clearance/inactivation of viruses. By nanofiltration, large enveloped viruses (HSV-1, HIV-1) were completely eliminated by a factor of more than
[Donor exclusions, discarded blood and transfusion unsuited blood conserves of 2,13 million potential blood donors 1991 to 1994]: Beitr Infusionsther Transfusionsmed. 1996;33:81-92. Unique Identifier : AIDSLINE MED/97019436; Diekamp U; Wehrend W; Marklof E; Kamutzky K; DRK-Blutspendedienst NSOB, Springe, Deutschland.; German authorities plan to legislate transfusion safety. We report on the efficacy of donor selection, unit pre-release testing, quality assurance and look-back efforts (LBE): Among 2,127,102 visits by 503,971 donors are 8.7% first-time donors. 96% of repeaters present our donor ID-card. We defer 5.6% repeat and 18.2%
High frequencies of human T-lymphotropic virus type I (HTLV-I) infection and presence of HTLV-II proviral DNA in blood donors with anti-thyroid antibodies.: J Mol Med. 1996 Aug;74(8):471-7. Unique Identifier : AIDSLINE MED/97026683; Mine H; Kawai H; Yokoi K; Akaike M; Saito S; First Department of Internal Medicine, School of Medicine,; University of Tokushima, Japan.; To investigate the relationship between human T-lymphotropic virus (HTLV) types I and II and the pathogenesis of autoimmune thyroid diseases, we examined serum anti-thyroid antibodies in 1019 blood donors with or without serum anti-HTLV-I antibody as well as proviral DNA for HTLV-II in leukocyte DNA by the polymerase
Interesting resources from the Web.: NP News. 1996 Jul-Aug;4(4):2, 5. Unique Identifier : AIDSLINE MED/97086737; Smithing RT; Wiley MD
Rhegmatogenous retinal detachments in HIV-positive patients with ocular syphilis.: Ophthalmic Surg Lasers. 1996 Aug;27(8):699-705. Unique Identifier : AIDSLINE MED/97011626; Williams JK; Kirsch LS; Russack V; Freeman WR; Department of Ophthalmology, University of California at San; Diego, La Jolla 92093-0946, USA.; The purpose of this study is to report retinal manifestations of lues in human immunodeficiency virus (HIV)-positive patients and to suggest a method for treatment of rhegmatogenous retinal detachments in these patients. Two HIV-positive patients with bilateral retinitis were examined and treated at the authors insti
TH2 cells in allergic inflammation: a target of immunotherapy.: Clin Exp Allergy. 1996 Jul;26(7):756-65. Unique Identifier : AIDSLINE MED/96440237; Lord CJ; Lamb JR; Department of Biology, Imperial College of Science, Technology; and Medicine, London, UK.
Experimental graft versus host disease in the (BN x LEW) F1 rat hybrid: an immunohistochemical study of early disease in oral mucosa.: Oral Dis. 1996 Mar;2(1):2-10. Unique Identifier : AIDSLINE MED/97116847; Peszkowski MJ; Fujiwara K; Warfvinge G; Larsson A; Department of Oral Pathology, Lund University, Malmo, Sweden.; OBJECTIVE: To study the initial cellular events in oral mucosa (tongue) of experimental hyperplastic GVHD, in order to increase our understanding of the possible pathogenic mechanisms that may be shared with eg mercury (and other drug)-induced immunological reactions. MATERIALS AND METHODS: GVHD was induced by one i.v
Knowledge of and attitudes about blood-borne viruses and infection control in Brazilian dental practice.: Oral Dis. 1996 Mar;2(1):41-4. Unique Identifier : AIDSLINE MED/97116851; Jorge J; Jorge R; Almeida OP; Scully C; Department of Oral Pathology, Faculty of Odontology, Piracicaba; SP, Brazil.; OBJECTIVE: To determine whether there were any recent changes in hepatitis B immunisation of dental staff, infection control or understanding of viral infections in Brazilian dentists. DESIGN: A randomised survey was conducted on 740 dentists attending the National Dental Congress in Sao Paulo, Brazil in 1994. SUBJECT
The periodontal health of homosexual men with HIV infection: a controlled study.: Oral Dis. 1996 Mar;2(1):45-52. Unique Identifier : AIDSLINE MED/97116852; Robinson PG; Sheiham A; Challacombe SJ; Zakrzewska JM; Department of Epidemiology and Public Health, University College,; London, UK.; OBJECTIVE: Identify types, prevalence and severity of periodontal changes associated with HIV infection. DESIGN: Cross-sectional controlled blinded study. SETTING: Open access genito-urinary medicine clinic. PARTICIPANTS: Convenience sample of 794 homosexual men aged 18-65. OUTCOME MEASURES: Prevalence, extent and sev
Cellular immunity and hypersensitivity as components of periodontal destruction.: Oral Dis. 1996 Mar;2(1):96-101. Unique Identifier : AIDSLINE MED/97116858; Seymour GJ; Gemmell E; Kjeldsen M; Yamazaki K; Nakajima T; Hara K; Department of Dentistry, University of Queensland, Brisbane,; Australia.; BACKGROUND: Cellular immunity has been implicated in periodontal destruction for over 25 years. Studies in the 1970s used lymphocyte transformation and lymphokine assays to establish a role for cell-mediated mechanisms in periodontal disease. Immunohistological studies subsequently showed that the formation of gingivi
Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease.: Mol Med. 1996 Jan;2(1):27-37. Unique Identifier : AIDSLINE MED/97056192; Lane TE; Buchmeier MJ; Watry DD; Fox HS; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA.; BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can lead to severe impairments in cognition, behavior, and motor skills. The mechanism(s) by which HIV-1 induces CNS disease are not well understood. Recent evidence suggests that expression of inducible nitric oxide
Role of IgE immune complexes in the regulation of HIV-1 replication and increased cell death of infected U1 monocytes: involvement of CD23/Fc epsilon RII-mediated nitric oxide and cyclic AMP pathways.: Mol Med. 1996 Jan;2(1):38-49. Unique Identifier : AIDSLINE MED/97056193; Ouaaz F; Ruscetti FW; Dugas B; Mikovits J; Agut H; Debre P; Mossalayi MD; Molecular Immuno-hematology Group, CNRS URA625,; Pitie-Salpetriere Hospital, Paris, France.; BACKGROUND: IgE/anti-IgE immune complexes (IgE-IC) induce the release of multiple mediators from monocytes/macrophages and the monocytic cell line U937 following the ligation of the low-affinity Fc epsilon receptors (Fc epsilon RII/CD23). These effects are mediated through an accumulation of cAMP and the generation of
Neurovirulent simian immunodeficiency virus infection induces neuronal, endothelial, and glial apoptosis.: Mol Med. 1996 Jul;2(4):417-28. Unique Identifier : AIDSLINE MED/96425269; Adamson DC; Dawson TM; Zink MC; Clements JE; Dawson VL; Department of Neuroscience, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21287, USA.; BACKGROUND: Studies of human immunodeficiency virus type 1 (HIV-1) associated dementia have shown neuronal loss in discrete areas. The presence and mechanism of neuronal death, however, has remained quite elusive. One mechanism of cell death, apoptosis, has been clearly demonstrate
Overexpression of select T cell receptor V beta gene families within CD4+ and CD8+ T cell subsets of myasthenia gravis patients: a role for superantigen(s)?: Mol Med. 1996 Jul;2(4):452-9. Unique Identifier : AIDSLINE MED/96425272; Gigliotti D; Lefvert AK; Jeddi-Tehrani M; Esin S; Hodara V; Pirskanen R; Wigzell H; Andersson R; Microbiology and Tumorbiology Center (MTC), Karolinska Institute,; Stockholm, Sweden.; BACKGROUND: The principal symptoms of myasthenia gravis (MG), muscle weakness and fatigue due to impaired neuromuscular transmission, are caused by autoantibodies to the muscle nicotinic acetylcholine receptor (AChR). The mechanisms underlying the autoimmune response, however, appear to be initiated by activation of s
A critical role of nitric oxide in human immunodeficiency virus type 1-induced hyperresponsiveness of cultured monocytes.: Mol Med. 1996 Jul;2(4):460-8. Unique Identifier : AIDSLINE MED/96425273; Bukrinsky M; Schmidtmayerova H; Zybarth G; Dubrovsky L; Sherry B; Enikolopov G; Picower Institute for Medical Research, Manhasset, New York.; BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infection leads to a general exhaustion of the immune system. Prior to this widespread decline of immune functions, however, there is an evident hyperactivation of the monocyte/macrophage arm. Increased levels of cytokines and other biologically active molecules
[Apoptosis in the nervous system]: Rev Neurol. 1996 Nov;24(135):1356-60. Unique Identifier : AIDSLINE MED/97090712; Macaya A; Seccion de Neurologia Infantil, Centro de Investigaciones en; Bioquimica y Biologia Molecular, Vall d'Hebron Hospitals,; Barcelona.; Apoptosis (programmed cell death) is a distinct form of controlled cell degeneration, different from necrosis. It serves multiple physiological functions, such as the control of cell numbers during development, the maintenance of tissue homeostasis and the deletion of abnormal cells. Apoptosis has unique morphological
[Changes in the immunocompetent cell system of the peripheral blood in HIV carriage]: Lik Sprava. 1995 Mar-Apr;(3-4):112-5. Unique Identifier : AIDSLINE MED/96417148; Karabanov VR; Markov IS; Marchenko NE; HIV-carriage is characterized by hematological signs such as normocytosis of the general leucocyte count and deviations within normal range of values for myeloid series cells (neutrophiles, eosinophiles, basophiles). A peculiar hematological sign seen in HIV-infection is a finding of a raised content of cellular eleme
[A case of Kaposi's sarcoma of the eye in an AIDS patient]: Lik Sprava. 1995 Mar-Apr;(3-4):172-4. Unique Identifier : AIDSLINE MED/96417168; Barshtein IuA; Vovk AD; Antoniak SM; Shcherbyns'ka AM
Infectious disease challenges in the 1990's.: Med Health R I. 1996 Mar;79(3):100-9. Unique Identifier : AIDSLINE MED/97056951; Opal SM; Infectious Disease Fellowship Program, Brown University School of; Medicine, USA.
Physicians should support needle exchange in Rhode Island [editorial]: Med Health R I. 1996 Jun;79(6):206. Unique Identifier : AIDSLINE MED/96390291; Lewis DC; Rich JD; Brown University Center for Alcohol and Addiction Studies, USA.
AIDS and minorities.: Med Health R I. 1996 Jul;79(7):264-5. Unique Identifier : AIDSLINE MED/96390306; Fisher AE; Emgushov RT; Brown University School of Medicine, Providence, RI, USA.
Antisense oligonucleotides inhibit in vitro cDNA synthesis by HIV-1 reverse transcriptase.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):103-9. Unique Identifier : AIDSLINE MED/97000182; Boiziau C; Tarrago-Litvak L; Sinha ND; Moreau S; Litvak S; Toulme JJ; INSERM U386, Universite Bordeaux II, France.; The inhibition of reverse transcription by various chemically modified antisense oligonucleotides was studied in a cell-free system, composed of an RNA template, a primer oligodeoxynucleotide, and the HIV-1 reverse transcriptase (RT). Different mechanisms of inhibition were observed depending on the chemical structure
Correlation of activity with stability of chemically modified ribozymes in nuclei suspension.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):111-8. Unique Identifier : AIDSLINE MED/97000183; Heidenreich O; Xu X; Swiderski P; Rossi JJ; Nerenberg M; Scripps Research Institute, Department of Molecular and; Experimental Medicine, La Jolla, CA 92037, USA.; To examine hammerhead ribozyme activity in the nuclear environment, we have used nuclei isolated from HTLV-I tax transformed fibroblasts to evaluate ribozymes targeted against HTLV-I tax RNA. The ribozyme activity in nuclei suspension was strongly dependent on the resistance of the particular ribozyme to endogenous nu
A hammerhead ribozyme cleaves its target RNA during RNA preparation.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):141-4. Unique Identifier : AIDSLINE MED/97000187; Heidenreich O; Xu X; Nerenberg M; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, CA 92037, USA.; A chemically modified hammerhead ribozyme was designed to cleave the tax RNA of human T cell leukemia virus type I. This ribozyme was exogenously delivered to tax-transformed fibroblasts by DOTAP-mediated transfection. The analysis of RNA from ribozyme-transfected cells by RNase protection detected ribozyme cleavage p
4-(Arylamino)phenyl alpha-D-glucopyranosides as potential anti-HIV agents.: Carbohydr Res. 1996 Mar 18;282(2):293-8. Unique Identifier : AIDSLINE MED/97056753; Briggs JC; Haines AH; School of Chemical Sciences, University of East Anglia, Norwich,; United Kingdom.
Structure of the O-deacetylated glucuronoxylomannan from Cryptococcus neoformans Cap70 as determined by 2D NMR spectroscopy.: Carbohydr Res. 1996 Mar 22;283:95-110. Unique Identifier : AIDSLINE MED/97056926; Bacon BE; Cherniak R; Kwon-Chung KJ; Jacobson ES; Department of Chemistry, Georgia State University, Atlanta 30303,; USA.; Cryptococcus neoformans, an opportunistic pathogen, is the fourth leading cause of death among AIDS patients. The yeast s capsule is a major virulence factor, and serotype is related to the chemical structure of glucuronoxylomannan (GXM), its capsular polysaccharide. The GXM from Cap70, a hypocapsular mutant of seroty
Immune response against medullary thyroid carcinoma (MTC) induced by parental and/or interleukin-2-secreting MTC cells in a rat model of human familial medullary thyroid carcinoma.: Cancer Immunol Immunother. 1996 Oct;43(2):116-23. Unique Identifier : AIDSLINE MED/97112466; Lausson S; Fournes B; Borrel C; Milhaud G; Treilhou-Lahille F; Laboratoire d'Endocrinologie Cellulaire et Evolution, U. R. A.; 1116 CNRS, Universite Paris-Sud, Centre d'Orsay, France.; The existence of inherited aggressive forms of medullary thyroid carcinoma (MTC), and their resistance to all classical therapies, make it a prime candidate for adoptive immunotherapy. As a prelude to a vaccine for the protection of family members at risk of developing the disease, we investigated the immunological an
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.: Cell. 1996 Nov 15;87(4):745-56. Unique Identifier : AIDSLINE MED/97083584; Endres MJ; Clapham PR; Marsh M; Ahuja M; Turner JD; McKnight A; Thomas JF; Stoebenau-Haggarty B; Choe S; Vance PJ; Wells TN; Power CA; Sutterwala SS; Doms RW; Landau NR; Hoxie JA; Hematology-Oncology Division, University of Pennsylvania,; Philadelphia 19104, USA.; Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these molecules serve as CD4-associated cofactors is unclear. In the present report, we show that one member of this family, termed Fusin/ CXCR4, is
The use of SCID mice in biotechnology and as a model for human disease.: Crit Rev Biotechnol. 1996;16(1):95-118. Unique Identifier : AIDSLINE MED/97090002; Sandhu JS; Boynton E; Gorczynski R; Hozumi N; Department of Surgery, University of Toronto, Ontario, Canada.; The use of SCID (severe combined immunodeficient) mice in medical research and biotechnology has increased tremendously in recent years. This review outlines the major characteristics of these animals and the impediments that they pose to the engraftment of human cells and tissues. The development of our SCID mice pre
New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors.: Chem Pharm Bull (Tokyo). 1996 Aug;44(8):1436-9. Unique Identifier : AIDSLINE MED/96387794; Yoshida T; Ito H; Hatano T; Kurata M; Nakanishi T; Inada A; Murata H; Inatomi Y; Matsuura N; Ono K; Nakane H; Noda M; Lang FA; Murata J; Faculty of Pharmaceutical Sciences, Okayama University, Japan.; Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have
Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell leukaemia (ATL) and in HTLV-I carriers.: Clin Endocrinol (Oxf). 1996 Oct;45(4):461-6. Unique Identifier : AIDSLINE MED/97118203; Akamine H; Takasu N; Komiya I; Ishikawa K; Shinjyo T; Nakachi K; Masuda M; Second Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; OBJECTIVE: Human T-lymphotrophic virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukaemia (ATL). This virus is associated with a variety of autoimmune disorders. The possible association between HTLV-I Infection and autoimmune thyroiditis has not been fully studied. We therefore evaluated anti-thyroid
The association of hepatitis C viral infection with porphyria cutanea tarda in the Lothian region of Scotland.: Clin Exp Dermatol. 1996 Jul;21(4):283-5. Unique Identifier : AIDSLINE MED/97119077; Hussain I; Hepburn NC; Jones A; O'Rourke K; Hayes PC; Centre for Liver and Digestive Disorders, Royal Infirmary of; Edinburgh, Scotland.; Porphyria cutanea tarda (PCT) is believed to be associated with reduced hepatic uroporphyrinogen decarboxylase activity and risk factors such as alcohol abuse and medication with oral contraceptives and certain other drugs. Recently it has been suggested that hepatitis C virus (HCV) infection may also be associated wi
Inhibition of classical complement activation by sera from HIV-1-positive patients.: Clin Immunol Immunopathol. 1996 Nov;81(2):114-21. Unique Identifier : AIDSLINE MED/97064122; Burek V; Gerencer M; Department of Clinical Immunology, University Hospital of; Infectious Diseases Dr Fran Mihaljevic, University of Zagreb,; Croatia.; It was shown that gp120/160-coupled CD4+ T cells could be lysed by complement activation, but the target cell lysis was strongly inhibited by the majority of HIV-1-positive sera. Significantly more sera from HIV-1-infected patients with CD4+ T cell count higher than 500 microl (N = 38) as well as from patients with 20
Lymphocyte muscarinic cholinergic activity and PGE2 involvement in experimental Trypanosoma cruzi infection.: Clin Immunol Immunopathol. 1996 Nov;81(2):122-8. Unique Identifier : AIDSLINE MED/97064123; Sterin-Borda L; Gorelik G; Goren N; Cappa SG; Celentano AM; Borda E; CEFYBO-CONICET, Catedras de Microbiologia y Farmacologia,; Facultad de Medicina y de Odontologia, Universidad de Buenos; Aires, Argentina.; In this paper, we demonstrated that the production of PGE2 by CD8+ T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethal Trypanosoma cruzi CA-1 strain could enhance resistance to infection. Treatment in vivo with either atropine or cyclooxygen
Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome.: Clin Immunol Immunopathol. 1996 Nov;81(2):129-35. Unique Identifier : AIDSLINE MED/97064124; Kawabata K; Nagasawa M; Morio T; Okawa H; Yata J; Department of Pediatrics, School of Medicine, Tokyo Medical and; Dental University, Japan.; Cell surface CD8 molecules exist as either alpha/alpha homodimers or alpha/beta heterodimers, and most CD8+ T cells that undergo differentiation in the thymus express alpha/beta heterodimers. CD8 molecules on peripheral blood lymphocytes of patients with Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency dis
Serum and secretory IgA from HIV-infected individuals mediate antibody-dependent cellular cytotoxicity.: Clin Immunol Immunopathol. 1996 Nov;81(2):182-90. Unique Identifier : AIDSLINE MED/97064131; Black KP; Cummins JE Jr; Jackson S; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170, USA.; The potential function of IgA anti-HIV antibodies in mediation of antibody-dependent cellular cytotoxicity (ADCC) was investigated in this study. Serum IgA isolated from HIV-seropositive subjects in stage B3 or C3 and from healthy seronegative individuals was compared to IgG and whole serum for the ability to mediate
HIV disease in children is associated with a selective decrease in CD23+ and CD62L+ B cells.: Clin Immunol Immunopathol. 1996 Nov;81(2):191-9. Unique Identifier : AIDSLINE MED/97064132; Rodriguez C; Thomas JK; O'Rourke S; Stiehm ER; Plaeger S; Department of Pediatrics, UCLA School of Medicine, Los Angeles,; California 90095, USA.; We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude
Comparison of the Vbeta repertoire in peripheral blood and in lymph nodes of HIV-infected subjects reveals skewed usage predominantly in CD8+ T cells.: Clin Immunol Immunopathol. 1996 Nov;81(2):200-9. Unique Identifier : AIDSLINE MED/97064133; Carbonari M; Cibati M; Pesce AM; Dell'Anna L; D'Offizi G; Angelici A; Uccini S; Fiorilli M; Department of Clinical Medicine, University of Rome La Sapienza,; Italy.; Perturbations of the repertoire of variable-beta (Vbeta) regions of the T cell receptor have been observed in patients infected by HIV and have been attributed to stimulation by viral antigens or superantigens. We further sought for traces of HIV-induced perturbations by comparing Vbeta repertoire in peripheral blood
Abnormalities of CD45 isoform expression in HIV infection.: Clin Immunol Immunopathol. 1996 Nov;81(2):210-4. Unique Identifier : AIDSLINE MED/97064134; Mahalingam M; Pozniak A; McManus TJ; Senaldi G; Vergani D; Peakman M; Department of Immunology, King's College Hospital, London, United; Kingdom.; Using monoclonal antibodies against CD45, CD45RA, CD45RB, and CD45RO, the surface density of expression and proportions of different CD45 isoforms were analyzed on CD4+ and CD8+ T lymphocyte subsets in HIV+ patients and controls. Analysis of the relative specific fluorescence (RSF) of CD45 isoforms showed a significan
Volumetric capillary cytometry: a new method for absolute cell enumeration.: Cytometry. 1996 Mar 1;23(3):177-86. Unique Identifier : AIDSLINE MED/97077010; Dietz LJ; Dubrow RS; Manian BS; Sizto NL; Biometric Imaging, Mountain View, California 94043, USA.; This article describes a novel cytometry system that is capable of imaging, identifying, and counting populations of fluorescently labeled cells within a precisely known volume of unlysed whole blood contained in a precision capillary. The whole blood is reacted with dye-labeled antibodies directed at cell surface ant
Improved four-color flow cytometry method using fluo-3 and triple immunofluorescence for analysis of intracellular calcium ion ([Ca2+]i) fluxes among mouse lymph node B- and T-lymphocyte subsets.: Cytometry. 1996 Mar 1;23(3):205-17. Unique Identifier : AIDSLINE MED/97077013; Greimers R; Trebak M; Moutschen M; Jacobs N; Boniver J; Laboratory of Pathological and Cytological Anatomy, University; Hospital of Liege, Belgium.; A visible-light, dual-laser, flow cytometric method was developed for the simultaneous analysis of intracellular ionized calcium concentration ([Ca2+]i) and three cell-surface markers (CD4, CD8, and Thy-1.2 antigens) by using the calcium probe fluo-3 and using R-phycoerythrin (PE), peridinin chlorophyll-alpha protein
[AIDS patients for pain therapy often have to rely on an opiate (news)]: Dtsch Med Wochenschr. 1996 Nov 15;121(46):A45. Unique Identifier : AIDSLINE MED/97128153
Tissue-specific self-peptides bound by major histocompatibility complex class I molecules of a human pancreatic beta-cell line.: Diabetes. 1996 Dec;45(12):1761-5. Unique Identifier : AIDSLINE MED/97081081; Papadopoulos KP; Colovai AI; Maffei A; Jaraquemada D; Suciu-Foca N; Harris PE; Department of Medicine, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; The process of beta-cell destruction in IDDM is mediated, in part, by CD8+ T-cells. Structural characterization of HLA-I-bound self-peptides presented by the human beta-cell line HP-62 was performed to identify possible tissue-specific autoantigens in the context of CD8+ T-cell/HLA-I interactions. The sequences of the
American Gastroenterological Association medical position statement: guidelines for the management of malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection.: Gastroenterology. 1996 Dec;111(6):1722-3. Unique Identifier : AIDSLINE MED/97098214
AGA technical review: malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection.: Gastroenterology. 1996 Dec;111(6):1724-52. Unique Identifier : AIDSLINE MED/97098215; Wilcox CM; Rabeneck L; Friedman S; Department of Medicine, University of Alabama at Birmingham, USA.
Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1.: Gene. 1996 Oct 31;178(1-2):7-13. Unique Identifier : AIDSLINE MED/97080539; Wang L; Mukherjee S; Narayan O; Zhao LJ; Marion Merrell Dow Foundation, Department of Microbiology,; Molecular Genetics and Immunology, University of Kansas Medical; Center, Kansas City 66160-7424, USA.; Human immunodeficiency virus type 1 (HIV-1) replicates productively in vitro in CD4(+)-T cells and/or macrophages. In the host, however, HIV-1 replication may be restricted by the quiescence of susceptible cells. Vpr is a 15-kDa late viral gene product, which is assembled in the virion and suspected to enhance HIV-1 r
[AIDS as a social problem]: Gig Sanit. 1996 Sep-Oct;(5):40-2. Unique Identifier : AIDSLINE MED/97061985; Sidorenko GI; Vashkova VV; Mozhaev EA; Rotova EG
A cervical teratoma with invasive squamous cell carcinoma in an HIV-infected patient: a case report.: Gynecol Oncol. 1996 Mar;60(3):475-9. Unique Identifier : AIDSLINE MED/96370764; Bell MC; Schmidt-Grimminger DC; Connor MG; Alvarez RD; Department of Obstetrics and Gynecology, University of Alabama at; Birmingham 35233, USA.; HIV infection among women is increasing in the United States . Since January 1993, cervical cancer has been considered an AIDS-defining illness. We report a rare case of squamous cell carcinoma arising in a teratoma of the uterine cervix in an HIV-infected patient. This patient was trea
Invasive vulvar carcinoma in two women infected with human immunodeficiency virus.: Gynecol Oncol. 1996 Mar;60(3):500-3. Unique Identifier : AIDSLINE MED/96370771; Wright TC; Koulos JP; Liu P; Sun XW; Department of Pathology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; This report presents two HIV-infected women who developed invasive squamous cell carcinoma of the vulva. One patient was diagnosed with Stage II vulvar cancer 4 years after surgical excision of VIN. This patient underwent a hemivulvectomy and external-beam radiation therapy, but has subsequently developed recurrent vu
[Atypical mycoses--also a sequela of medical progress (interview by Dr. rer. nat. Anita Schweiger)]: Fortschr Med. 1996 Aug 20;114(22-23):14-5. Unique Identifier : AIDSLINE MED/96415331; Mayser P
Assessment of adult sibling grief: a review of measurement issues.: Hosp J. 1996;11(1):1-18. Unique Identifier : AIDSLINE MED/97077741; Robinson L; Pickett M; Over the past decade hospice care has been delivered to an increasing population of persons with Acquired Immunodeficiency Syndrome (PWAS) and their families. Adult siblings likely comprise a large number of these surviving family members. Investigations that examine sibling bereavement are scarce (Osterweis, Solomon
Quantifying phagocytosis of Mycobacterium avium complex by human monocytes in whole blood.: Immunol Cell Biol. 1996 Aug;74(4):306-12. Unique Identifier : AIDSLINE MED/97026000; Hewish MJ; Meikle AM; Hunter SD; Crowe SM; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; Studies of phagocytic efficiency in cells of the macrophage lineage have assumed additional importance since the discovery that HIV infection of these cells impairs their immune function. A rapid method has been developed for measuring phagocytosis of the opportunistic pathogen Mycobacterium avium complex by human mon
Anal and cervical abnormality in women--prediction by human papillomavirus tests.: Int J Cancer. 1996 Nov 27;68(5):559-64. Unique Identifier : AIDSLINE MED/97092714; Melbye M; Smith E; Wohlfahrt J; Osterlind A; Orholm M; Bergmann OJ; Mathiesen L; Darragh TM; Palefsky JM; Department of Epidemiology Research, Statens Serum Institut,; Copenhagen, Denmark. mmelbye@desc.ssi.dk; A total of 151 women at risk of human immunodeficiency virus infection were investigated, to study the strength of the association between cervix and anus regarding the presence of HPV and cytological abnormality. An equal percentage of women had abnormal cervical (12.2%) and anal (12.1%) Papanicolaou smears. HPV meas
Psychodynamic group therapy with adolescents: exploration of HIV-related risk taking.: Int J Group Psychother. 1996 Apr;46(2):229-53. Unique Identifier : AIDSLINE MED/97089856; Henry RM; Department of Psychology, University of Wollongong, Australia.; Recent research shows that adolescents are a high-risk group for HIV infection, and that educational campaigns designed to reduce risk taking concerning HIV/AIDS have been largely ineffective with this population. It is probable that irrational psychodynamic processes underlie this risky behavior. In order to explore
Focusing on living: attitudinal approaches of long-term survivors of AIDS.: Issues Ment Health Nurs. 1996 Sep-Oct;17(5):395-407. Unique Identifier : AIDSLINE MED/97077772; Barroso J; This naturalistic study reports the attitudinal approaches of long-term survivors of AIDS. Ethnographic interviewing techniques were employed to interview a purposive sample of 14 men and 6 women who had had AIDS for at least 3 years and who were living in the Tampa/St. Petersburg, FL, area. As part of a larger study
Teen perspectives on HIV and the relevance of Hawaii's health providers.: Hawaii Med J. 1996 Oct;55(10):205-11. Unique Identifier : AIDSLINE MED/97097500; Bidwell RJ; Mueller CW; Mann E; Mew S; Goo C; Dunbar H; McGrady G; Vera M; Liebow E; Lovely RH; Department of Pediatrics, John A. Burns School of Medicine,; University of Hawaii, Honolulu 96826, USA.; Based on focus group interviews with adolescents from an urban Honolulu community, the present article describes how these adolescents view HIV, HIV-prevention and the role of health care providers in addressing HIV-related needs. Although medical providers are known to be knowledgeable experts in a variety of health
Safe intravenous antibiotic therapy at home: experience of a UK based programme.: J Antimicrob Chemother. 1996 May;37(5):1023-9. Unique Identifier : AIDSLINE MED/96346916; Kayley J; Berendt AR; Snelling MJ; Moore H; Hamilton HC; Peto TE; Crook DW; Conlon CP; East Oxford Health Centre, UK.; Outpatient i.v. antibiotic therapy is well developed in the United States , largely because of pressures from third-party payers to reduce costs of medical care. We have developed an outpatient i.v. antibiotic programme in Oxford, that has evolved from a desire to provide high quality i
Fluconazole plus allopurinol in treatment of visceral leishmaniasis [letter]: J Antimicrob Chemother. 1996 May;37(5):1042-3. Unique Identifier : AIDSLINE MED/96346924; Torrus D; Boix V; Massa B; Portilla J; Perez-Mateo M
Current therapeutic approaches to cryptosporidiosis in immunocompromised patients.: J Antimicrob Chemother. 1996 May;37(5):871-80. Unique Identifier : AIDSLINE MED/96346899; Hoepelman AI; Department of Medicine, University Hospital, Utrecht, The; Netherlands.; Cryptosporidium parvum is a protozon which can cause a severe debilitating disease in immunocompromised patients. Animal models show that cellular immunity is the most important factor protecting against the development of the disease, but patients with a humoral immune deficiency are also at risk. In HIV-infected pat
Arkansas HIV/AIDS report 1983-1996.: J Ark Med Soc. 1996 May;92(12):636-7. Unique Identifier : AIDSLINE MED/97090117
Synthesis of full-length viral DNA in CD4-positive membrane vesicles exposed to HIV-1. A model for studies of early stages of the hiv-1 life cycle.: J Biol Chem. 1996 Nov 8;271(45):28266-70. Unique Identifier : AIDSLINE MED/97067043; Simm M; Pekarskaya O; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center and College of Physicians & Surgeons, Columbia University,; New York, New York 10019, USA. djv@columbia.edu; CD4-positive membrane vesicles (MV) were isolated under isotonic conditions from human T lymphoblastoid cells MT-2 and CEM and tested for their ability to support reverse transcription of viral RNA upon exposure to human immunodeficiency virus, type 1 (HIV-1). MV contained cytoplasms as confirmed by the presence of mi
AIDS-related obsessive compulsive disorder: deconditioning based on fluoxetine-induced inhibition of anxiety.: J Behav Ther Exp Psychiatry. 1996 Mar;27(1):51-6. Unique Identifier : AIDSLINE MED/96409539; Kraus RP; Nicholson IR; Department of Psychiatry, University of Western Ontario, London,; Canada.; Abel s (1993) review of treatments for obsessive compulsive disorder (OCD) indicated that both behavioral treatment (exposure with response prevention, and biological treatment (specific serotonin reuptake inhibiting drugs) are effective. It was recognized that having both available for patients is preferable because
Unusual pattern of enhancement in cryptococcal meningitis: in vivo findings with postmortem correlation.: J Comput Assist Tomogr. 1996 Nov-Dec;20(6):1023-6. Unique Identifier : AIDSLINE MED/97087874; Arnder L; Castillo M; Heinz ER; Scatliff JH; Enterline D; Department of Radiology, University of North Carolina School of; Medicine, Chapel Hill, USA.; Leptomeningeal enhancement on CT and MR imaging studies secondary to cryptococcal meningitis is an uncommon finding. In immunocompromised patients, this meningitis incites only a mild inflammatory reaction and abnormalities are often absent on imaging studies. We recently encountered two patients with cryptococcal men
Comparison of in-phase and opposed-phase GRE and conventional SE MR pulse sequences in T1-weighted imaging of liver lesions.: J Comput Assist Tomogr. 1996 Nov-Dec;20(6):890-7. Unique Identifier : AIDSLINE MED/97087848; Martin J; Sentis M; Puig J; Rue M; Falco J; Donoso L; Zidan A; Unitat de Diagnostic per la Imatge D'Alta Tecnologia (UDIAT),; Consorci Hospitalari del Parc Tauli, Barcelona, Spain.; PURPOSE: Our goal was to compare in-phase (IP) and opposed-phase (OP) GRE and conventional SE sequences in T1-weighted (T1-W) imaging of the liver and to evaluate chemical shift GRE imaging in characterizing liver/lesions for fat content. METHOD: IP and OP T1-W GRE with fast low angle shot (FLASH) technique and T1-W S
Using factor analysis to explore nurses' fear of AIDS in the United States of America.: J Adv Nurs. 1996 Aug;24(2):287-95. Unique Identifier : AIDSLINE MED/97011422; Wang JF; Paterson J; Department of Health Systems, School of Nursing, West Virginia; University, Morgantown 26508-9610, USA.; The purpose of this study was to create a reliable research instrument to test the fear of AIDS (FOA) and to explore the dimension of FOA among nurses. We hypothesized that certain factors, such as physical closeness to AIDS patients or HIV-positive blood and nontolerance of homosexuals, increase fear of AIDS among nu
Effects of group discussion and guided patient care experience on nurses' attitudes towards care of patients with AIDS.: J Adv Nurs. 1996 Aug;24(2):296-302. Unique Identifier : AIDSLINE MED/97011423; Kemppainen JK; Dubbert PM; McWilliams P; University of California, San Francisco, USA.; Nurses with limited experience in caring for persons with AIDS (PWAs) were randomized into three groups receiving an educational session on universal precautions and (a) three group discussion sessions; (b) three sessions of caring for a PWA; or (c) assessment materials only. Both interventions were conducted by a nur
The regulation of the development of CD8 effector T cells.: J Immunol. 1996 Nov 15;157(10):4287-92. Unique Identifier : AIDSLINE MED/97064182; Dutton RW; Trudeau Institute, Saranac Lake, NY 12983, USA.
Impaired signaling in alloantigen-specific CD8+ T cells tolerized in vivo: employing a model of Ld-specific TCR transgenic mice transplanted with allogenic hearts under the cover of a short-term rapamycin treatment.: J Immunol. 1996 Nov 15;157(10):4297-308. Unique Identifier : AIDSLINE MED/97064184; Chen H; Luo H; Xu D; Loh DY; Daloze PM; Veillette A; Qi S; Wu J; Louis-Charles Simard Research Center, Notre-Dame Hospital,; University of Montreal, Canada.; Peripheral tolerance of T cells is necessary because thymic deletion is not complete, and tissue-specific Ags exist outside the thymus. We have reported that persistent Ag is required to maintain peripheral tolerance in vivo. We suspect that the TCR signaling pathway in in vivo tolerized cells is compromised due to co
Lack of IL-12 signaling in human allergen-specific Th2 cells.: J Immunol. 1996 Nov 15;157(10):4316-21. Unique Identifier : AIDSLINE MED/97064186; Hilkens CM; Messer G; Tesselaar K; van Rietschoten AG; Kapsenberg ML; Wierenga EA; Department of Cell Biology and Histology, Academic Medical; Center, University of Amsterdam, The Netherlands.; IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells. In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells. To this aim
Reciprocal cytotoxic T lymphocyte cross-reactivity interactions between two major epitopes within HIV-1 gp160.: J Immunol. 1996 Nov 15;157(10):4399-411. Unique Identifier : AIDSLINE MED/97064196; Shirai M; Kurokohchi K; Pendleton CD; Arichi T; Boyd LF; Takahashi H; Margulies DH; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, Bethesda, MD 20892, USA.; We have observed and analyzed an unexpected cross-reactivity of CD8+ CTL between two nonhomologous peptides of the HIV-1 IIIB gp160 envelope protein, P18 (residues 315-329) and HP53 (834-848, also called TH4.1), in the context of four different class I MHC molecules, Dd, Dp, Dq (or Lq), and H-2u. In strains expressing
Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+NK1.1- T cell population.: J Immunol. 1996 Nov 15;157(10):4421-7. Unique Identifier : AIDSLINE MED/97064198; von der Weid T; Beebe AM; Roopenian DC; Coffman RL; Department of Immunology, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, CA 94304, USA.; Splenic CD4+NK1.1+ T cells have been shown to secrete large and transient amounts of IL-4 mRNA 90 min after i.v. injection of anti-CD3 Ab, suggesting that this novel subset of T cells may induce Th2 responses in the spleen by quickly providing IL-4 at the onset of an immune response. beta2-microglobulin-deficient (bet
Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes.: J Immunol. 1996 Nov 15;157(10):4464-73. Unique Identifier : AIDSLINE MED/97064204; Malarkannan S; Gonzalez F; Nguyen V; Adair G; Shastri N; Department of Molecular and Cell Biology, University of; California, Berkeley 94720, USA.; The identity and abundance of self-peptide/MHC class I complexes that serve as ligands for alloreactive T cells remain largely unknown. Using the Kb-restricted, alloreactive T cells as a probe, the Ag precursor gene, adenosine phosphoribosyl transferase (APRT), was isolated by expression cloning. Its naturally process
The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice.: J Immunol. 1996 Nov 15;157(10):4546-53. Unique Identifier : AIDSLINE MED/97064214; Metwali A; Elliott D; Blum AM; Li J; Sandor M; Lynch R; Noben-Trauth N; Weinstock JV; Department of Internal Medicine, University of Iowa, Iowa City; 52242, USA.; IL-4 plays an important role in polarizing inflammation toward a Th2 response. It remains uncertain, however, whether IL-4 also serves to prevent expression of Th1 inflammation. Therefore, using a genetically pure C57BL/6 IL-4-deficient mouse, we studied the role of IL-4 in regulating the production of IFN-gamma and T
Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production.: J Immunol. 1996 Nov 15;157(10):4602-8. Unique Identifier : AIDSLINE MED/97064220; Chensue SW; Warmington KS; Ruth JH; Sanghi PS; Lincoln P; Kunkel SL; Department of Pathology, Veterans Affairs Medical Center, Ann; Arbor, MI 48105, USA.; The present study examined the contribution of monocyte chemotactic protein-1 (MCP-1) to granulomatous inflammation mediated by Th1- and Th2-related cytokines. Types 1 and 2 lung granulomas (GR) were respectively induced in presensitized CBA mice by embolization of beads coupled to purified protein derivative of Mycob
Selection of T cells reactive against autologous B lymphoblastoid cells during chronic rheumatoid arthritis.: J Immunol. 1996 Nov 15;157(10):4697-706. Unique Identifier : AIDSLINE MED/97064232; David-Ameline J; Lim A; Davodeau F; Peyrat MA; Berthelot JM; Semana G; Pannetier C; Gaschet J; Vie H; Even J; Bonneville M; INSERM Unit 211, Institute of Biology, Nantes, France.; The repertoire and Ag specificity of T cells infiltrating inflamed joints from a chronic rheumatoid arthritis (RA) patient were studied in detail. Repertoire analysis demonstrated a reduced clonality of joint-infiltrating lymphocytes (JIL) as compared with patient s PBL, which was presumably due to an intra-articular
IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice.: J Immunol. 1996 Dec 1;157(11):4746-50. Unique Identifier : AIDSLINE MED/97098698; Szalay G; Ladel CH; Blum C; Kaufmann SH; Department of Immunology, University of Ulm, Germany.; Successful control of infectious disease depends on aquisition of an appropriate protective immune response. IFN-gamma, first produced by NK cells and then by Th1 cells, is central to acquired resistance against intracellular bacteria, including Listeria monocytogenes. In contrast, IL-4 is not generated to a measurabl
Deficient expression of p56(lck) in Th2 cells leads to partial TCR signaling and a dysregulation in lymphokine mRNA levels.: J Immunol. 1996 Dec 1;157(11):4751-61. Unique Identifier : AIDSLINE MED/97098699; al-Ramadi BK; Nakamura T; Leitenberg D; Bothwell AL; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06520, USA.; Activation of T lymphocytes through their TCR is regulated by a delicate balance of phosphorylation and dephosphorylation of protein substrates by protein tyrosine kinases (PTKs) and phosphotyrosyl phosphatases, respectively. One of the earliest steps in the activation pathway is thought to involve the Src family PTKs
Recipient CD8+ cells are responsible for the rapid elimination of allogeneic donor lymphoid cells.: J Immunol. 1996 Dec 1;157(11):4805-10. Unique Identifier : AIDSLINE MED/97098705; Fast LD; Department of Medicine, Rhode Island Hospital and Brown; University School of Medicine, Providence 02903, USA.; Blood transfusion can result in a variety of immunologic responses, including alloimmunization, transfusion-associated graft-versus-host disease, and immunosuppression that results in increased postoperative infection rate, and can also result in increased survival of allografts. One of the many factors influencing th
Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.: J Immunol. 1996 Dec 1;157(11):4811-21. Unique Identifier : AIDSLINE MED/97098706; Fowler DH; Breglio J; Nagel G; Eckhaus MA; Gress RE; Transplantation Therapy Section, Medical Oncology Branch,; National Cancer Institute, National Institutes of Health,; Bethesda, MD 20892, USA.; Allogeneic CD8+ T cells mediate both a graft-vs-leukemia (GVL) effect and graft-vs-host disease (GVHD). To evaluate whether CD8 cells of defined cytokine phenotype differentially mediate these processes, alloreactive donor CD8+ T cells preferentially secreting type I or type II cytokines were generated by alloantigeni
Loss of either CD4+ or CD8+ T cells does not affect the magnitude of protective immunity to an intracellular pathogen, Francisella tularensis strain LVS.: J Immunol. 1996 Dec 1;157(11):5042-8. Unique Identifier : AIDSLINE MED/97098736; Yee D; Rhinehart-Jones TR; Elkins KL; Laboratory of Enteric and Sexually Transmitted Diseases, Division; of Bacterial Products, Center for Biologics Evaluation and; Research, Rockville, MD 20852, USA.; Normal mice readily survive a sublethal intradermal (i.d.) infection with Francisella tularensis live vaccine strain (LVS), a model intracellular bacterium, and are strongly protected against subsequent lethal challenge. However, athymic nu/nu mice, which lack mature alphabeta TCR+ T lymphocytes, succumb to i.d. infec
Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis.: J Immunol. 1996 Dec 1;157(11):5170-7. Unique Identifier : AIDSLINE MED/97098752; Arai K; Yamamura S; Hanyu T; Takahashi HE; Umezu H; Watanabe H; Abo T; Department of Immunology, Niigata University School of Medicine,; Japan.; Murine collagen-induced arthritis (CIA) is known as a T cell-mediated autoimmune disease, although autoantibodies are also suspected to be associated with the onset of the disease. To determine the origin of such T cells in the joints of mice with CIA, their phenotypic properties as well as those of T cells in other i
Experience of human lymphotropic virus type I (HTLV-I) in an East London hospital.: J Infect. 1996 Jan;32(1):33-9. Unique Identifier : AIDSLINE MED/97005238; Hoque S; Kelsey S; van der Walt JD; Breuer J; Department of Medical Microbiology, Royal London Hospital, U.K.; We describe the experience of The Royal London Hospital with human T-cell lymphotropic virus type 1 (HTLV-1) related disease. Twelve patients presented from 1988-1993, nine of them in 1993. None were born in the U.K. and 11 were of West Indian origin. Ten had overt lymphomas, one tropical spastic paraparesis/HTLV-1 as
The epidemiology of HIV infection in Edinburgh related to the injecting of drugs: an historical perspective and new insight regarding the past incidence of HIV infection derived from retrospective HIV antibody testing of stored samples of serum.: J Infect. 1996 Jan;32(1):53-62. Unique Identifier : AIDSLINE MED/97005241; Burns SM; Brettle RP; Gore SM; Peutherer JF; Robertson JR; Regional Virus Laboratory, City Hospital, Edinburgh, U.K.; The pattern of sudden explosive outbreaks of HIV infection among drug users has been seen in several countries but is as yet incompletely understood. The epidemic of injecting drugs in Edinburgh was associated with at least four overlapping epidemics of blood-borne viruses (hepatitis B, C, D and HIV). Only hepatitis B
Toxoplasma pneumonia in Africa [letter]: J Infect. 1996 Jan;32(1):70. Unique Identifier : AIDSLINE MED/97005245; Doherty JF; Chiposi L; Gwanzura L; Mason PR; Beaman MH
Ocular melanoma and human immunodeficiency virus infection.: Insight. 1996 Sep;21(3):86-8. Unique Identifier : AIDSLINE MED/97112813; Abramson DH; Servodidio CA; The number of reports of malignant complications of human immunodeficiency virus infection is increasing. Cutaneous melanoma has been previously reported in five patients with human immunodeficiency virus infection, but no cases of ocular melanoma have been documented. We describe the first case of ocular melanoma rep
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.: J Exp Med. 1996 Nov 1;184(5):1651-61. Unique Identifier : AIDSLINE MED/97079123; Morawetz RA; Gabriele L; Rizzo LV; Noben-Trauth N; Kuhn R; Rajewsky K; Muller W; Doherty TM; Finkelman F; Coffman RL; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Immunoglobulin (Ig) class switching in B cells is regulated by stimuli transduced by cytokines and cell-cell contact. Among these stimuli, interleukin (IL)-4 has been considered an absolute prerequisite for class switching to IgE in the mouse. Here we report that IL-4-deficient (IL-4-/-) and wildtype mice had comparab
Domains of the TCR beta-chain required for early thymocyte development.: J Exp Med. 1996 Nov 1;184(5):1833-43. Unique Identifier : AIDSLINE MED/97079139; Jacobs H; Iacomini J; van de Ven M; Tonegawa S; Berns A; Division of Molecular Genetics, The Netherlands Cancer Institute,; Amsterdam, The Netherlands.; The T cell receptor beta (TCR beta) chain controls the developmental transition from CD4-CD8- to CD4+8+thymocytes. We show that the extracellular constant region and the transmembrane region, but not the variable domain or cytoplasmic tail of the TCR beta chain are required for this differentiation step. TCR beta muta
CD4+ but not CD8+ cells are essential for allorejection.: J Exp Med. 1996 Nov 1;184(5):2013-8. Unique Identifier : AIDSLINE MED/97079156; Krieger NR; Yin DP; Garrison Fathman C; Department of Medicine, Stanford University School of Medicine,; California 94305, USA.; The generation of knockout mice with targeted gene disruption has provided a valuable tool for studying the immune response. Here we describe the use of CD4 and CD8 knockout mice to examine the role of CD4+ and CD8+ cells in initiating allotransplantation rejection. Pretreatment with a brief course of depletive anti-C
Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.: J Exp Med. 1996 Nov 1;184(5):2031-6. Unique Identifier : AIDSLINE MED/97079159; Taylor N; Bacon KB; Smith S; Jahn T; Kadlecek TA; Uribe L; Kohn DB; Gelfand EW; Weiss A; Weinberg K; Division of Research Immunology and Bone Marrow Transplantation,; Children's Hospital, Los Angeles, California 90027, USA.; A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires the association of
Is a case study approach effective in altering the attitudes of student nurses toward AIDS?: J N Y State Nurses Assoc. 1996 Jun;27(2):13-7. Unique Identifier : AIDSLINE MED/97056434; Scherer YK; Dickerson S; Grzankowski J; The effect of a case study approach on attitudes of sophomore nursing students toward caring for patients with AIDS was examined. Pre- and post-program attitudes of 36 students were measured using an AIDS questionnaire. No significant differences were found between pre- and post-program scores on the questionnaire. An
Children's perceptions of peers with AIDS: assessing the impact of contagion information, perceived similarity, and illness conceptualization.: J Pediatr Psychol. 1996 Jun;21(3):321-33. Unique Identifier : AIDSLINE MED/97089328; Maieron MJ; Roberts MC; Prentice-Dunn S; Minnesota Epilsepsy Group, P. A., USA.; Assessed factors that affected acceptance of a hypothetical peer with AIDS. Children in Grades 4-6 read vignettes containing one of four levels of contagion information and one of two levels of perceived similarity. Illness conceptualization was measured as a continuous variable. Results indicated that the type of AID
Impairment of expressive behavior in pediatric HIV-infected patients with evidence of CNS disease.: J Pediatr Psychol. 1996 Jun;21(3):379-400. Unique Identifier : AIDSLINE MED/97089332; Moss HA; Wolters PL; Brouwers P; Hendricks ML; Pizzo PA; Pediatric Branch, National Cancer Institute, Rockville Pike,; Bethesda, Maryland 20892, USA.; Rated observations of videotapes were made of 16 variables representing 5 behavioral domains (task orientation, positive social-emotional, motor skills, expressive speech, and activity) on a sample of 83 HIV-infected children. Comparisons were made on the rated behaviors between children classified as either encephalo
Effect of formulation and processing factors on the characteristics of biodegradable microcapsules of zidovudine.: J Microencapsul. 1996 Sep-Oct;13(5):545-57. Unique Identifier : AIDSLINE MED/97018376; Mandal TK; Shekleton M; Onyebueke E; Washington L; Penson T; College of Pharmacy, Xavier University of Louisiana, New Orleans; 70125, USA.; Biodegradable microcapsules of zidovudine ( AZT ) were prepared using poly-(lactide/glycolide) by the solvent evaporation technique. The objective of this project was to focus on the effect of several formulation and processing factors on the efficiency
Synthesis of alpha-glucosidase I inhibitors showing antiviral (HIV-1) and immunosuppressive activity.: J Pharm Pharmacol. 1996 Feb;48(2):172-8. Unique Identifier : AIDSLINE MED/97089258; van den Broek LA; Kat-Van Den Nieuwenhof MW; Butters TD; Van Boeckel CA; Department of Medicinal Chemistry, N.V. Organon, Netherlands.; The synthesis of a series of analogues of the monosaccharide alpha-glucosidase I inhibitor N-decyl-1-deoxynojirimycin (1) is described. With the incorporation of a single oxygen atom particularly at position seven in the N-decyl side chain, i.e. to give N-7-oxadecyl-dNM (4), the therapeutic ratio (alpha-glucosidase I
College students' judgements and perceptions of persons with AIDS from different risk groups.: J Psychol. 1996 Sep;130(5):527-36. Unique Identifier : AIDSLINE MED/97019010; Johnson ME; Baer AJ; Department of Psychology, University of Alaska Anchorage 99508,; USA.; In this analog study, 104 female and 75 male undergraduate students in the United States read 1 of 8 vignettes that described a person who had just received positive HIV antigen results. The vignettes were identical except for the sex of the person described and his or her risk-group m
Risk behaviors, self-efficacy, and AIDS prevention among adolescents.: J Psychol. 1996 Sep;130(5):537-46. Unique Identifier : AIDSLINE MED/97019011; Goh DS; Primavera C; Bartalini G; Graduate Program in School Psychology, City University of New; York-Queens College, Flushing 11367, USA.; This study was conducted to investigate risk behaviors and AIDS-preventive variables in high school adolescents. One hundred fifty-two students in Grades 10 through 12 were administered an AIDS-related behavior questionnaire and the Attitudes Toward AIDS Scale-High School Version (ATAS-HS; Goh, 1992). The results indi
Expression of membrane form of the pregnancy associated protein TJ6 on decidual lymphocytes in the first trimester of pregnancy.: J Reprod Immunol. 1996 Feb;30(1):17-27. Unique Identifier : AIDSLINE MED/97077598; Rubesa G; Beaman KD; Beer AE; Haller H; Rukavina D; Department of Physiology and Immunology, University of Rijeka,; Croatia.; TJ6, a newly described protein produced locally in the uterine decidua during pregnancy, may be involved in maintaining a unique immunological environment at the maternal-fetal interface. The aim of this study was to determine whether TJ6 is expressed as membrane form on decidual lymphocytes (DL), to define the phenot
HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity.: J Mol Biol. 1996 Nov 22;264(1):20-31. Unique Identifier : AIDSLINE MED/97107524; Yin MJ; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center Dallas 75235-8594, USA.; The human T-cell leukemia virus type I (HTLV-I) transactivator protein Tax is critical for the activation of viral gene expression and the transformation of T-lymphocytes. Tax activation of HTLV-I gene expression is mediated by three highly homologous regulatory elements known as 21 bp repeats which bind the transcrip
HIV-1 reverse transcriptase discriminates against non-self tRNA primers.: J Mol Biol. 1996 Nov 29;264(2):243-54. Unique Identifier : AIDSLINE MED/97109094; Oude Essink BB; Das AT; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.; The interactions between the Reverse Transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) and the natural tRNA(Lys3) primer for initiation of viral DNA synthesis were examined. We constructed a set of HIV-1 RNA templates in which the wild-type primer binding site (PBS(Lys3)) is replaced by sequences compl
Oligonucleotide inhibitors of Taq DNA polymerase facilitate detection of low copy number targets by PCR.: J Mol Biol. 1996 Nov 29;264(2):268-78. Unique Identifier : AIDSLINE MED/97109096; Dang C; Jayasena SD; NeXstar Pharmaceuticals Inc., Boulder, CO 80301, USA.; A random sequence library of single stranded DNA was screened to isolate sequences with high affinity for Thermus aquaticus DNA polymerase (Taq pol), a thermostable enzyme commonly used in the polymerase chain reaction (PCR). Selected oligonucleotide sequences bound Taq pol with dissociation constants in the low picom
alpha-Interferon-2b treatment for chronic hepatitis-B infection in children with cancer.: J Trop Pediatr. 1996 Oct;42(5):262-6. Unique Identifier : AIDSLINE MED/97091220; Cetingul N; Kavakli K; Vergin C; Oztop S; Nisli G; Aydogdu S; Ozacar T; Bilgic A; Yuce G; Yagci R; Department of Pediatric Hematology-Oncology, Ege University,; Faculty of Medicine, Bornova, Izmir, Turkey.; We have evaluated the efficacy of treatment with recombinant Interferon-2b (IFN-2b) in 12 children with cancer who developed chronic hepatitis-B infection. Seven of them had lymphoblastic leukaemia and others had solid tumours. Seven cases were male. Mean age was 10.5 years with a range of 5-16 years. Chronic Hepatiti
Vitamin A deficiency and T-cell subpopulations in children with meningococcal disease.: J Trop Pediatr. 1996 Oct;42(5):287-90. Unique Identifier : AIDSLINE MED/97091225; Semba RD; Bulterys M; Munyeshuli V; Gatsinzi T; Saah A; Chao A; Dushimimana A; Department of Ophthalmology, School of Medicine, Johns Hopkins; University, Baltimore, MD, USA.; Although group A meningococcal disease is a major cause of child morbidity and mortality in sub-Saharan Africa, little is known about vitamin A status and T-cell subpopulations in affected children. A prospective study of vitamin A levels and T-cell subpopulations was conducted in 41 children hospitalized for meningoc
A source of glycosylated human T-cell lymphotropic virus type 1 envelope protein: expression of gp46 by the vaccinia virus/T7 polymerase system.: J Virol. 1996 Nov;70(11):7349-59. Unique Identifier : AIDSLINE MED/97048012; Arp J; LeVatte M; Rowe J; Perkins S; King E; Leystra-Lantz C; Foung SK; Dekaban GA; Gene Therapy and Molecular Virology Group, John P. Robarts; Research Institute, London, Ontario, Canada.; Heterologous expression of the human T-cell lymphotropic virus type 1 (HTLV-1) envelope surface glycoprotein (gp46) in a vaccinia virus/T7 polymerase system resulted in the production of authentic recombinant gp46. Five differentially glycosylated forms of the surface envelope protein were produced by this mammalian s
Tumor necrosis factor alpha inhibits entry of human immunodeficiency virus type 1 into primary human macrophages: a selective role for the 75-kilodalton receptor.: J Virol. 1996 Nov;70(11):7388-97. Unique Identifier : AIDSLINE MED/97048016; Herbein G; Montaner LJ; Gordon S; Sir William Dunn School of Pathology, University of Oxford,; United Kingdom.; The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) is readily detected after human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages in vitro and is present in plasma and tissues of patients with AIDS. Previous studies have shown that human recombinant TNFalpha (hrTNFalpha) enhanc
Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.: J Virol. 1996 Nov;70(11):7462-70. Unique Identifier : AIDSLINE MED/97048023; Hu H; Shioda T; Moriya C; Xin X; Hasan MK; Miyake K; Shimada T; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Minato-ku, Japan.; The envelope protein, gp120, of human immunodeficiency virus type 1 (HIV-1) is heavily glycosylated and sialylated. The heavy sialylation greatly affects the physical properties of the protein, as it resolves into a wide acidic pH range despite the basic pI value predicted for its polypeptide backbone (B. S. Stein and
The oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae.: J Virol. 1996 Nov;70(11):7478-84. Unique Identifier : AIDSLINE MED/97048025; Shnyreva M; Munder T; Department of Cell and Molecular Biology, Hans-Knoll-Institut; fur Naturstoff-Forschung e.V., Jena, Germany.; The transcription factor Tax of the oncogenic human T-cell leukemia virus type 1 is likely to be responsible for viral replication in the host organism and for the induction of proliferation in infected cells. To investigate Tax-mediated transcription in vivo, we expressed Tax as well as CREB in Saccharomyces cerevisi
Anergic TH1 clones specific for hepatitis B virus (HBV) core peptides are inhibitory to other HBV core-specific CD4+ T cells in vitro.: J Virol. 1996 Nov;70(11):7540-8. Unique Identifier : AIDSLINE MED/97048032; Diepolder HM; Jung MC; Wierenga E; Hoffmann RM; Zachoval R; Gerlach TJ; Scholz S; Heavner G; Riethmuller G; Pape GR; Institute for Immunology, University of Munich, Germany.; A strong and transient hepatitis B virus core (HBc)-specific CD4+ T-cell response has been shown to be associated with viral elimination in acute self-limited hepatitis B but to be absent in chronic hepatitis B. So far, little is known about immunological mechanisms involved in the regulation of the HBc-specific CD4+
Feline immunodeficiency virus vaccination: characterization of the immune correlates of protection.: J Virol. 1996 Nov;70(11):7561-8. Unique Identifier : AIDSLINE MED/97048034; Hosie MJ; Flynn JN; MRC Retrovirus Research Laboratory, Department of Veterinary; Pathology, University of Glasgow, Bearsden, United Kingdom.; m.hosie@vet.gla.ac.uk.; Whole inactivated virus (WIV) vaccines derived from the FL4 cell line protect cats against challenge with feline immunodeficiency virus (FIV). To investigate the correlates of protective immunity induced by WIV, we established an immunization regimen which protected a proportion of the vaccinates against challenge. A
Progression to persistent lymphocytosis and tumor development in bovine leukemia virus (BLV)-infected cattle correlates with impaired proliferation of CD4+ T cells in response to gag- and env-encoded BLV proteins.: J Virol. 1996 Nov;70(11):7584-93. Unique Identifier : AIDSLINE MED/97048037; Orlik O; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin--Madison, 53706, USA.; The mechanism of leukemogenesis and persistent lymphocytosis (PL; benign expansion of B lymphocytes) in cattle infected with bovine leukemia virus (BLV; a retrovirus closely related to human T-cell leukemia virus type 1) is unknown; however, the immune system likely plays an important role in controlling the outcome o
Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo.: J Virol. 1996 Nov;70(11):7603-13. Unique Identifier : AIDSLINE MED/97048039; Bagnarelli P; Valenza A; Menzo S; Sampaolesi R; Varaldo PE; Butini L; Montroni M; Perno CF; Aquaro S; Mathez D; Leibowitch J; Balotta C; Clementi M; Istituto di Microbiologia, Universita di Ancona, Italy.; The dynamics of human immunodeficiency virus type 1 (HIV-1) transcription was analyzed in vitro and in vivo by using a specific molecular approach which allows accurate quantitation of the different classes of viral mRNAs. Unspliced (US) and multiply spliced (MS) HIV-1 transcripts were assayed by competitive reverse t
Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: evidence of differential tropism.: J Virol. 1996 Nov;70(11):7654-62. Unique Identifier : AIDSLINE MED/97048044; Strizki JM; Albright AV; Sheng H; O'Connor M; Perrin L; Gonzalez-Scarano F; Department of Neurology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6146, USA.; To ascertain whether viruses present at the time of primary viremia can infect the central nervous system and to determine if microglial tropism is distinct from tropism for monocyte-derived macrophages (MDM), 27 human immunodeficiency virus type 1 (HIV-1) isolates obtained from acutely infected individuals, as well a
In vivo transcriptional regulation of the human immunodeficiency virus in the central nervous system in transgenic mice.: J Virol. 1996 Nov;70(11):7686-94. Unique Identifier : AIDSLINE MED/97048048; Kurth J; Buzy JM; Lindstrom L; Clements JE; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205, USA.; Human immunodeficiency virus type 1 (HIV-1) causes infections of the central nervous system (CNS) and has been implicated as the causative agent of AIDS-associated encephalopathy and the AIDS dementia complex. The development of in vivo models of HIV-1-mediated gene expression has
Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.: J Virol. 1996 Nov;70(11):7706-12. Unique Identifier : AIDSLINE MED/97048050; Gargano N; Biocca S; Bradbury A; Cattaneo A; International School for Advanced Studies, Trieste, Italy.; We describe in this paper the binding and biochemical properties of two human antibody fragments directed against the human immunodeficiency virus type 1 reverse transcriptase (RT). These fragments were isolated from a synthetic combinatorial library of human Fab antibody fragments displayed on the surface of filament
Cytotoxic T-lymphocyte responses to cytomegalovirus in normal and simian immunodeficiency virus-infected rhesus macaques.: J Virol. 1996 Nov;70(11):7725-33. Unique Identifier : AIDSLINE MED/97048052; Kaur A; Daniel MD; Hempel D; Lee-Parritz D; Hirsch MS; Johnson RP; Division of Immunology, New England Regional Primate Center,; Southborough, Massachusetts 01772, USA.; Disseminated cytomegalovirus ( CMV ) infection is a frequent occurrence in human immunodeficiency virus-infected humans and in simian immunodeficiency virus (SIV)-infected rhesus macaques. Rhesus macaques are a suitable animal
Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.: J Virol. 1996 Nov;70(11):7734-43. Unique Identifier : AIDSLINE MED/97048053; Ott DE; Coren LV; Kane BP; Busch LK; Johnson DG; Sowder RC 2nd; Chertova EN; Arthur LO; Henderson LE; AIDS Vaccine Program, National Cancer Institute, Frederick Cancer; Research and Development Center, Maryland 21702-1201, USA.; ott@avpvx1.ncifcrf.gov.; We have identified three types of cytoskeletal proteins inside human immunodeficiency virus type 1 (HIV-1) virions by analyzing subtilisin-digested particles. HIV-1 virions were digested with protease, and the treated particles were isolated by sucrose density centrifugation. This method removes both exterior viral pr
High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.: J Virol. 1996 Nov;70(11):7752-64. Unique Identifier : AIDSLINE MED/97048055; Mariani R; Kirchhoff F; Greenough TC; Sullivan JL; Desrosiers RC; Skowronski J; Cold Spring Harbor Laboratory, New York 11724, USA.; A large number of nef alleles were obtained from peripheral blood mononuclear cells (PBMC) of four long-term nonprogressing survivors of human immunodeficiency virus type 1 (HIV-1) infection and from five individuals with progressive HIV-1 infection. These primary nef alleles were characterized by DNA sequence analysi
Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.: J Virol. 1996 Nov;70(11):7765-72. Unique Identifier : AIDSLINE MED/97048056; Junker U; Escaich S; Plavec I; Baker J; McPhee F; Rose JR; Craik CS; Bohnlein E; Progenesys Program at Systemix, Palo Alto, California 94304, USA.; The enzymatic activity of the human immunodeficiency type 1 (HIV-1) protease (PR) is crucial to render HIV-1 virions mature and infectious. Hence, genetic intervention strategies based on trans-dominant (td) variants of the HIV-1 PR might be an alternative to current pharmacological and gene therapy regimens for AIDS.
Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.: J Virol. 1996 Nov;70(11):7773-82. Unique Identifier : AIDSLINE MED/97048057; Chen W; Qin H; Chesebro B; Cheever MA; Division of Oncology, Department of Medicine, University of; Washington, Seattle 98195, USA. wchen@cesmtp.ccf.org.; FBL-3 is a highly immunogenic murine leukemia of C57BL/6 origin induced by Friend murine leukemia virus (MuLV). Immunization of C57BL/6 mice with FBL-3 readily elicits CD8+ cytotoxic T lymphocytes (CTL) capable of lysing FBL-3 as well as syngeneic leukemias induced by Moloney and Rauscher MuLV. The aim of this current
Generation of atypical pulmonary inflammatory responses in BALB/c mice after immunization with the native attachment (G) glycoprotein of respiratory syncytial virus.: J Virol. 1996 Nov;70(11):7783-91. Unique Identifier : AIDSLINE MED/97048058; Hancock GE; Speelman DJ; Heers K; Bortell E; Smith J; Cosco C; Department of Immunology, Lederle-Praxis Biologicals, Inc., West; Henrietta, New York 14586-9728, USA.; The feasibility of using the highly purified native attachment (G) protein in a subunit vaccine against respiratory syncytial virus (RSV) was examined in a murine model with or without the fusion (F) protein of RSV and the adjuvant QS-21. The studies established that QS-21 was more potent than AIOH as an adjuvant for
Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro.: J Virol. 1996 Nov;70(11):7792-803. Unique Identifier : AIDSLINE MED/97048059; Chang J; Naif HM; Li S; Sullivan JS; Randle CM; Cunningham AL; Virology Department, ICPMR, Westmead Hospital, University of; Sydney, National Centre in HIV Research, New South Wales,; Australia.; Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy
Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization.: J Virol. 1996 Nov;70(11):7827-32. Unique Identifier : AIDSLINE MED/97048063; Weber J; Fenyo EM; Beddows S; Kaleebu P; Bjorndal A; Department of Communicable Diseases, Imperial College School of; Medicine at St. Mary's, London, United Kingdom.; Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand , Brazil , Rwanda , and Uganda , representing genetic subtypes A, B
Nevirapine-resistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients.: J Virol. 1996 Nov;70(11):7894-9. Unique Identifier : AIDSLINE MED/97048071; Havlir DV; Eastman S; Gamst A; Richman DD; Department of Medicine, University of California, San Diego; 92103, USA. dhavlir@ucsd.edu.; The nonnucleoside reverse transcriptase inhibitor nevirapine rapidly selects for mutant human immunodeficiency virus (HIV) in vivo. The most common mutation occurs at amino acid residue 181 in patients receiving monotherapy. After the initiation of ne
T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells.: J Virol. 1996 Nov;70(11):7958-64. Unique Identifier : AIDSLINE MED/97048078; Rizza P; Santini SM; Logozzi MA; Lapenta C; Sestili P; Gherardi G; Lande R; Spada M; Parlato S; Belardelli F; Fais S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The state of activation of the immune system may be an important factor which renders a host more receptive to human immunodeficiency virus (HIV) and more vulnerable to its effects. To explore this issue with a practical in vivo model, we developed a modified protocol of HIV infection in hu-PBL-SCID mice. First, we as
A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells.: J Virol. 1996 Nov;70(11):7992-8002. Unique Identifier : AIDSLINE MED/97048082; Shahabuddin M; Bentsman G; Volsky B; Rodriguez I; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center, New York, New York 10019, USA.; We characterized in detail the life cycle of human immunodeficiency virus type 1 (HIV-1) in human glioma H4/CD4 cells which stably express transfected CD4 DNA (B. Volsky, K. Sakai, M. Reddy, and D. J. Volsky, Virology 186:303-308, 1992). Infection of cloned H4/CD4 cells with the N1T strain of cell-free HIV-1 (HIV-1/N1
An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine.: J Virol. 1996 Nov;70(11):8010-8. Unique Identifier : AIDSLINE GENBANK/Z31355; Hooker DJ; Tachedjian G; Solomon AE; Gurusinghe AD; Land S; Birch C; Anderson JL; Roy BM; Arnold E; Deacon NJ; AIDS Molecular Biology Laboratory, Macfarlane Burnet Center for; Medical Research, Fairfield, Australia.; Sequencing of the reverse transcriptase (RT) region of 26 human immunodeficiency virus type 1 (HIV-1) isolates from eight patients treated with 3 -azido-3 -deoxythymidine ( AZT ) revealed a mutation at codon 210 from TTG (leucine) to TGG (tryptophan) ex
Postbinding events mediated by human immunodeficiency virus type 1 are sensitive to modifications in the D4-transmembrane linker region of CD4.: J Virol. 1996 Nov;70(11):8019-28. Unique Identifier : AIDSLINE MED/97048085; Moir S; Perreault J; Poulin L; Centre de Recherche en Infectiologie du Centre Hospitalier; Universitaire de Quebec, Canada.; Evidence from both structural and functional studies of the CD4 molecule suggests that several domains, including the transmembrane (TM) domain and the adjoining extracellular region (D4-TM linker), contribute to the post-gp12O-binding events leading to human immunodeficiency virus-mediated membrane fusion. To investi
Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm.: J Virol. 1996 Nov;70(11):8055-63. Unique Identifier : AIDSLINE MED/97048089; Orsini MJ; Debouck CM; Department of Molecular Genetics, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.; We introduced various mutations into the activation and RNA binding domains of human immunodeficiency virus type 1 (HIV-1) Tat in order to develop a novel and potent transdominant Tat protein and to characterize its mechanism of action. The different mutant Tat proteins were characterized for their abilities to activa
Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins.: J Virol. 1996 Nov;70(11):8089-97. Unique Identifier : AIDSLINE MED/97048093; Zhang QK; Boast S; de los Santos K; Begemann M; Goff SP; Department of Microbiology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; Retroviral genomes encoding a portion of the Moloney murine leukemia virus Gag protein fused to portions of the murine axl cDNA were constructed so as to mimic naturally occurring transforming viruses. Virus MA1 retained 5 amino acids of the extracellular domain and the complete transmembrane and intracellular domains
Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.: J Virol. 1996 Nov;70(11):8148-50. Unique Identifier : AIDSLINE MED/97048102; McCarty TC; Chattopadhyay SK; Scherer MT; Fredrickson TN; Hartley JW; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892, USA.; Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenes
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions.: J Virol. 1996 Nov;70(11):8151-4. Unique Identifier : AIDSLINE MED/97048103; Renne R; Lagunoff M; Zhong W; Ganem D; Howard Hughes Medical Institute and Department of Microbiology,; University of California, San Francisco 94143, USA.; The genome of a novel human herpesvirus has been detected in specimens of Kaposi s sarcoma (KS) and in several AIDS-related lymphoproliferative disorders. Here we examine the size and genomic conformation of the DNA of this virus (known as KS-associated herpesvirus or human herpesvirus 8) in latently and lytically inf
Human immunodeficiency virus type 1 capsid formation in reticulocyte lysates.: J Virol. 1996 Nov;70(11):8187-94. Unique Identifier : AIDSLINE MED/97048110; Spearman P; Ratner L; Department of Pediatrics, Vanderbilt University, Nashville,; Tennessee 37232-2581, USA.; The Gag polyprotein of human immunodeficiency virus (HIV) (Pr55Gag) contains sufficient information to direct particle assembly events when expressed within tissue culture cells. HIV Gag proteins normally form particles at a plasma membrane assembly site, in a manner analogous to that of the type C avian and mammalian
Human immunodeficiency virus type 1 subtypes defined by env show high frequency of recombinant gag genes. The UNAIDS Network for HIV Isolation and Characterization.: J Virol. 1996 Nov;70(11):8209-12. Unique Identifier : AIDSLINE MED/97048114; Cornelissen M; Kampinga G; Zorgdrager F; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; Amsterdam, The Netherlands.; Genetic subtypes of human immunodeficiency virus type 1 can be distinguished on the basis of phylogenetic analysis of their envelope (env) gene. A significant proportion of human immunodeficiency virus type 1 strains was retrospectively shown to result from recombination events between viruses belonging genetically to
HIV infection : primary care update. [videorecording]: [Oakland, Calif.] : Kaiser Foundation Health Plan, c1996 1 videocassette (50 min.) : sd., col. ; 1/2 in. + 1 guide (15 p.) Medicine in the nineties) Unique Identifier : AIDSLINE MED/9617388; Hammer H
SPID i opportunisticheskie virusnye neiroinfektsii.: Ekaterinburg : Izd-vo Ural'skogo universiteta, 1993 225 p. : ill Unique Identifier : AIDSLINE MED/9513735; Glinskikh NP
Aids e sexualidade : o ponto de vista da ciencias humanas.: Rio de Janeiro : Relume Dumara, c1994 246 p. : ill Unique Identifier : AIDSLINE MED/9600350; Loyola MA
AIDS : amores, transtornos e desgracas.: Sao Paulo : Livraria Pioneira Editora, c1994 xii, 123 p. : Colecao Novos umbrais) Unique Identifier : AIDSLINE MED/9517522; Amato Neto V
Epidemiologiia i profilaktika VICh-infektsii v voiskakh : uchebnoe posobie.: Sankt-Peterburg : Voenno-med. akademiia, 1994 61 p Unique Identifier : AIDSLINE MED/9610714; Zolochevskii MA
Seminario a epidemiologia social da aids : anais.: Rio de Janeiro : IMS, 1994 61 p. : ill Unique Identifier : AIDSLINE MED/9601706; Parker RG
El SIDA y la infeccion VIH en Republica Dominicana : documento de divulgacion.: Santo Domingo, D.N. : Secretaria de Estado de Salud Publica y Asistencia Social (SESPAS), Programa Control de Enfermedades de Transmision Sexual y SIDA (PROCETS), [1994] 25 p. : ill Unique Identifier : AIDSLINE MED/9614051; Baez C
Argentina, pais HIV : primera encuesta nacional sobre sexualidad y prevencion del SIDA.: Buenos Aires : Editorial Galerna, c1995 176, xiii p Unique Identifier : AIDSLINE MED/9614126; Frontera LA
Zur wissenschaftlichen Konstruktion von Krankheit am Beispiel AIDS.: Klagenfurt : Institut fur interdisziplinare Forschung und Fortbildung der Universitaten Innsbruck, Klagenfurt und Wien, [1995?] 155 leaves : ill (Klagenfurter Beitrage zur Technikdiskussion ; Heft 68) Unique Identifier : AIDSLINE MED/9609985; Zellacher L
Delivering HIV care in a managed care environment : issues and strategies : a meeting sponsored by the Kaiser Family Foundation in collaboration with the Health Resources and Services Administration : meeting summary.: Washington, DC (1450 G St., NW, Suite 250, Washington 20005) : Health Systems Research, [1996] 1 v. (various pagings) Unique Identifier : AIDSLINE MED/9617797; Bartlett L
HIV infection : primary care update. [videorecording]: [Oakland, Calif.] : Kaiser Foundation Health Plan, c1996 1 videocassette (50 min.) : sd., col. ; 1/2 in. + 1 guide (15 p.) (Medicine in the nineties) Unique Identifier : AIDSLINE AV/9617388; Hammer H
SPID i opportunisticheskie virusnye neiroinfektsii.: Ekaterinburg : Izd-vo Ural'skogo universiteta, 1993 225 p. : ill Unique Identifier : AIDSLINE CAT/9513735; Glinskikh NP
Aids e sexualidade : o ponto de vista da ciencias humanas.: Rio de Janeiro : Relume Dumara, c1994 246 p. : ill Unique Identifier : AIDSLINE CAT/9600350; Loyola MA
AIDS : amores, transtornos e desgracas.: Sao Paulo : Livraria Pioneira Editora, c1994 xii, 123 p. : (Colecao Novos umbrais) Unique Identifier : AIDSLINE CAT/9517522; Amato Neto V
Epidemiologiia i profilaktika VICh-infektsii v voiskakh : uchebnoe posobie.: Sankt-Peterburg : Voenno-med. akademiia, 1994 61 p Unique Identifier : AIDSLINE CAT/9610714; Zolochevskii MA
Seminario a epidemiologia social da aids : anais.: Rio de Janeiro : IMS, 1994 61 p. : ill Unique Identifier : AIDSLINE CAT/9601706; Parker RG
El SIDA y la infeccion VIH en Republica Dominicana : documento de divulgacion.: Santo Domingo, D.N. : Secretaria de Estado de Salud Publica y Asistencia Social (SESPAS), Programa Control de Enfermedades de Transmision Sexual y SIDA (PROCETS), [1994] 25 p. : ill Unique Identifier : AIDSLINE CAT/9614051; Baez C
Argentina, pais HIV : primera encuesta nacional sobre sexualidad y prevencion del SIDA.: Buenos Aires : Editorial Galerna, c1995 176, xiii p Unique Identifier : AIDSLINE CAT/9614126; Frontera LA
Zur wissenschaftlichen Konstruktion von Krankheit am Beispiel AIDS.: Klagenfurt : Institut fur interdisziplinare Forschung und Fortbildung der Universitaten Innsbruck, Klagenfurt und Wien, [1995?] 155 leaves : ill (Klagenfurter Beitrage zur Technikdiskussion ; Heft 68) Unique Identifier : AIDSLINE CAT/9609985; Zellacher L
Delivering HIV care in a managed care environment : issues and strategies : a meeting sponsored by the Kaiser Family Foundation in collaboration with the Health Resources and Services Administration : meeting summary.: Washington, DC (1450 G St., NW, Suite 250, Washington 20005) : Health Systems Research, [1996] 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9617797; Bartlett L
HIV-Ausbreitung und Pravention : epidemiologische Trends und praventive Strategien.: Weinheim : Juventa Verlag, 1996 206 p. : ill (Gesundheitsforschung) Unique Identifier : AIDSLINE CAT/9611876; Kramer A
HIV-Prophylaxe in einem computersimulierten Realitatsbereich.: Hamburg : Verlag Dr. Kovac, c1996 128 p. : ill Unique Identifier : AIDSLINE CAT/9610615; Bronner E
Choosing unsafe sex : AIDS-risk denial among disadvantaged women.: Philadelphia : University of Pennsylvania Press, c1995 ix, 232 p Unique Identifier : AIDSLINE CAT/9613934; Sobo EJ
Recent HIV seroprevalence levels by country : July 1995.: [Washington, D.C.] : Health Studies Branch, International Programs Center, Population Division, U.S. Bureau of the Census, [1995] v, 48 p. : ill (Research note ; no. 17) Unique Identifier : AIDSLINE CAT/9614239; Corbin J
The nature of the HIV/AIDS epidemic in sub-Saharan Africa.: [Canberra] : Australian National University, [1995] 22 p. : ill (Health Transition working paper ; no. 22) Unique Identifier : AIDSLINE CAT/9617680; Caldwell JC
Le sida et les fragilites francaises : nos reactions face a l'epidemie.: Paris : Albin Michel, c1995 376 p Unique Identifier : AIDSLINE CAT/9615537; Savigny Jd
Interventions to prevent HIV risk : January 1991 through November 1996.: Bethesda, Md. (8600 Rockville Pike) : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Reference Section ; Pittsburgh, PA. : Sold by the Supt. of Docs., U.S. G.P.O., 1996 (Current bibliographies in medicine ; 96-7) Unique Identifier : AIDSLINE CAT/9701253; Tillman PS; Pequegnat W; Interventions to Prevent HIV Risk Behaviors
Peregrinos del SIDA. 1. ed.: Santa Fe de Bogota, D.C., Colombia : Temas'de hoy, c1995 408 p (Coleccion Colombia hoy ; 2) Unique Identifier : AIDSLINE CAT/9616079; Canon M. L
Processo de desenvolvimento de vacinas anti-HIV/AIDS : problemas e beneficios : anais do seminario 1994 = Proces de developpement de vaccins anti-VIH/SIDA : problemes et beneficies : annales du seminaire 1994.: (Brazil) [Brasilia] : Ministerio da Saude, Secretaria de Assistencia a Saude, Programa Nacional de DST/AIDS. c1995 185 p Unique Identifier : AIDSLINE CAT/9601704
HIV-1 tat protein enhanced zidovudine-induced bone marrow toxicity (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A1958 1996. Unique Identifier : AIDSLINE ICDB/97631958; Chitnis S; Schmidt J; Mondal D; Biswas MK; Prakash O; Agrawal KC; Dept. of Pharmacology, Tulane Univ. Sch. of Medicine, New; Orleans, LA, 70112; The trans-activator protein (Tat) of HIV-1 has been shown in our laboratory to significantly inhibit butyric acid-induced differentiation in a hematopoietic progenitor cell line, K562, upon coculturing with HL-tat cells or transfection with an affinity purified GST-Tat fusion protein. We have investigated the role of
Azidothymidine enhances in vitro cisplatin and cisplatin plus 5-fluorouracil cytotoxicity against the human colorectal cancer cell line COLO-320DM (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A1985 1996. Unique Identifier : AIDSLINE ICDB/97631985; Andreuccetti M; Allegrini G; Antonuzzo A; Danesi R; Malvaldi G; Conte PF; Del Tacca M; Falcone A; Dept. Biomedicina, Sez. Patologia Generale, Via Roma 55 co Scuola; Medica, Pisa, Italy; Cisplatin (CDDP) and 5-Fluorouracil (5-FU) have demonstrated synergism which seems to be related to the inhibition of CDDP-DNA adducts repair by 5-FU. The toxic thymidine analogue azidothymidine ( AZT ) might also interfere with CDDP-DNA adducts repair
AZT is capable of modulating 5-FU resistance in human colon tumor cells (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A1993 1996. Unique Identifier : AIDSLINE ICDB/97631993; Szekeres T; Findenig G; Fritzer-Szekeres M; Mader R; Gobl R; Inst. of Medical Chemistry, Univ. of Vienna, Wahringerstrabe 10,; A-1090 Vienna, Austria; 5-Fluorouracil (5-FU) is an inhibitor of thymidylate synthase and clinically used in the treatment of several solid tumors, including colorectal, head and neck, gastric and pancreatic cancers. The drug effectively inhibits dNTP de novo synthesis, however this inhibition can be circumvented by increased thymidine kinas
Interleukin-12 (IL-12) induces lymphokine activated killer (LAK) activity in peripheral blood lymphocytes from recipients of autologous and allogeneic stem cell transplants (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A722 1996. Unique Identifier : AIDSLINE ICDB/97635722; Lindgren C; Robinson N; Keeler T; Thompson JA; Fefer A; Div. of Medical Oncology, Univ. of Washington, Seattle, WA; Interleukin-12 (IL-12) is a heterodimeric cytokine which has been reported to enhance the tumor cytotoxicity of NK and T cells, to induce low levels of LAK activity in normal human lymphocytes, and to be synergistic with IL-2 via independent pathways. In murine models,
Long-term use of DOX-SL (Stealth liposomal doxorubicin HCl) in the treatment of moderate to severe AIDS-related Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A842 1996. Unique Identifier : AIDSLINE ICDB/97635842; Jablonowski H; Boden D; Haussinger D; Department of Gastroenterology and Infectious Disease, University; of Dusseldorf, Germany; Advances in the design of liposomes as carriers of cytotoxic drugs have resulted in a new formulation of doxorubicin with improved pharmacokinetics and tumor localization. This new generation of liposomes, referred to as Stealth is characterized by a long circulation time with stable retention of drug, reduced hepatos
Reduced cardiotoxicity of DOXIL (pegylated liposomal doxorubicin) in AIDS Kaposi's sarcoma patients compared to a matched control group of cancer patients given doxorubicin (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A843 1996. Unique Identifier : AIDSLINE ICDB/97635843; Berry G; Billingham M; Alderman E; Torti F; Lum B; DuMond C; Martin F; Stanford Medical Center, Stanford, CA 94305; Doxorubicin (DOX)-induced cardiotoxicity can limit the duration of therapy with this agent and may be exacerbated by combination with newer agents such as taxanes. DOXIL , a pegylated liposome formulation of doxorubicin, is less cardiotoxic than DOX in rats, dogs and ra
Validation of the AIDS clinical trials group (ACTG) staging classification for AIDS-associated Kaposi's sarcoma (AIDS/KS) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A844 1996. Unique Identifier : AIDSLINE ICDB/97635844; Krown SE; Testa M; Huang J; Memorial Sloan-Kettering Cancer Center, New York, NY 10021; In 1989, the ACTG Oncology Committee published a proposal for staging of AIDS/KS (J Clin Oncol; 7:1201 1989) that classified patients into good-risk (subscript 0) and poor-risk (subscript 1) categories according to the extent of tumor (T), severity (CD4 greater than or equal to or less than 200/mm3) of immunosuppr
HIV-related cervical cancer (CA) in Italy; a report of 54 cases from the Italian Cooperative Group on AIDS and tumors (GICAT) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A845 1996. Unique Identifier : AIDSLINE ICDB/97635845; Spina M; Vaccher E; Sopracordevole F; Santarossa S; Torresin A; Rizzardini G; Conti M; Mangioni C; Scarabelli C; Tirelli U; Italian Cooperative Group on AIDS and Tumors, C.R.O., Aviano,; Italy; The incidence of cervical intraepithelial neoplasias has increased in HlV-infected women, and invasive cervical ca is currently considered an AIDS defining condition. However the natural history of HIV-related cervical ca is still unknown. To better characterize cervical ca in HIV-infected women we evaluated 54 cases,
Epirubicin, bleomycin, vinblastine and prednisone (EBVP) chemotherapy (CT) in combination with antiretroviral therapy and primary use of G-CSF for patients (pts) with Hodgkin's disease and HIV infection (HD-HIV) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A847 1996. Unique Identifier : AIDSLINE ICDB/97635846; Tirelli U; Errante D; Gisselbrecht C; Marolleau JP; Kerneis Y; Ridolfo A; Mazzetti M; Levis A; Veneri D; Rossi G; Spina M; Vaccher E; Division of Medical Oncology and AIDS, C.R.O. National Cancer; Institute, 33081 Aviano, Italy; The optimal therapeutic approach for pts with HD-HIV is unknown. In an attempt to improve the results that we obtained in a previous prospective study with EBV without G-CSF (Cancer 73:437-44, 1994), in January 1993 we started a second trial consisting of CT, concomitant antiretroviral therapy (
Age and LDH are independent prognostic factors also in HIV-related non-Hodgkin's lymphoma (HIV-NHL): a monoinstitutional study of 96 patients (pts) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A848 1996. Unique Identifier : AIDSLINE ICDB/97635848; Vaccher E; Spina M; Errante D; Tavio M; Nasti G; Simonelli C; Talamini R; Tirelli U; Division of Medical Oncology and AIDS, C.R.O. National Cancer; Institute, 33081 Aviano, Italy; In patients with HIV-NHL several prognostic factors have already been identified to correlate with survival: low CD4 count, prior history of AIDS and poor performance status (PS). The role of other prognostic factors, such as age, LDH, stage and multiple extranodal sites, that have been identified in intermediate-high
Low dose radiation in the treatment of HIV related benign lymphoepithelial lesions of the parotid gland (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A850 1996. Unique Identifier : AIDSLINE ICDB/97635850; Teng M; Tchelebi A; Moscatello A; Moorthy CR; Kaufmann T; Ahmed T; Department of Radiation, Westchester County Medical Center, New; York Medical College, Valhalla, NY 10595; At NYMC 17 patients with HIV related benign lymphoepithelial lesions of the parotid gland were treated with external beam radiation therapy from 1991 to 1995. Patients age ranged from 31 to 58 year old with a median age of 38 years; 10 patients were males and 5 were females. The median duration of symptoms was 1.5 yea
Mitoguazone dihydrochloride (MGBG) in combination with radiation therapy in the treatment of AIDS related primary CNS lymphoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A853 1996. Unique Identifier : AIDSLINE ICDB/97635853; Tulpule A; Espina BM; Montgomery T; VonHoff DD; Tessman D; Levine AM; University of Southern California, Los Angeles, CA; Prognosis for patients with AIDS-related primary central nervous system (CNS) lymphoma is very poor, with median survivals of 2-3 months, even with radiation therapy. Mitoguazone dihydrochloride (MGBG) at a dose of 600 mg/m2 given intravenously on day 1, 8 and then every 2 weeks has shown activity in patients with rel
Paclitaxel (Taxol) in the treatment of relapsed or refractory advanced AIDS-related Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A854 1996. Unique Identifier : AIDSLINE ICDB/97635854; Gill PS; Tulpule A; Reynolds T; Hadjenberg J; Mocharnuk R; Espina BM; Bresnahan J; Cabriales S; Ilaw M; Shea K; Scadden DT; University of Southern California School of Medicine, Los; Angeles, CA; Taxol is a potent cytotoxic agent with preliminary evidence of antitumor efficacy in patients with AIDS-related Kaposi s sarcoma (AIDS-KS). We studied AIDS-KS patients who relapsed or were refractory to at least one prior cytotoxic chemotherapy regimen. Low dose Taxol was given at a dose of 100 mg/m2 iv over 3 hours e
Long-term, disease free survival in AIDS-related lymphoma (AIDS-NHL) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A855 1996. Unique Identifier : AIDSLINE ICDB/97635855; Mocharnuk RS; Ghadialy A; Tulpule A; Espina B; Levine AM; USC School of Med., Los Angeles, CA 90033; Although lymphoma comprises approximately 3% of all initial AIDS defining illnesses, it is the cause of death in approximately 16% of AIDS patients. Lymphoma is thus felt to represent a late manifestation of HIV disease, with increasing numbers of patients expected as survival with HIV is prolonged. While advances in
Increase in CD4 cell number in AIDS patients with CD4 count below 200/mm3 by neuroimmunotherapy with subcutaneous low-dose IL-2 and the pineal hormone melatonin (MLT) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A857 1996. Unique Identifier : AIDSLINE ICDB/97635857; Lissoni P; Vigano MG; Giani L; Brivio F; Barni S; Ardizzoia A; Tancini G; Div. of Radiotherapy, S. Gerardo Hospital, Monza, Italy; IL-2 deficiency is the main AIDS-related immune disorder. Low levels of IL-2 are associated with a poor prognosis. At the other side, IL-2 injection has appeared to increase CD4 cell number in patients (pts) with CD4 count greater than 200/mm3, whereas no benefit was s
Low dose weekly paclitaxel for HIV associated Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A859 1996. Unique Identifier : AIDSLINE ICDB/97635859; Mega A; Akhtar MS; Safran H; Rich J; Sikov W; Flanigan T; Brown University Oncology Group, The Miriam Hospital, Providence,; RI; Paclitaxel is among the most active agents for Kaposi s sarcoma (KS) but its use in patients with HIV is limited by myelosupression. The Brown University Oncology Group has demonstrated that weekly paclitaxel may be more active and less myelosuppressive than a standard 21-day schedule. Therefore, we investigated a reg
Survival times of patients with AIDS-related Kaposi's sarcoma with pulmonary involvement using liposomal doxorubicin (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A860 1996. Unique Identifier : AIDSLINE ICDB/97635860; Goebel FD; Gruenaug M; Bogner JR; Med. Poliklinik, University of Munich, 80336 Munich, Germany; Pulmonary KS in HIV-infected pts carries a grave prognosis with a mean survival time between 2.1 and 6 months (JAIDS; 1:23 1988, Amer J Med; 87:57 1989). In a phase II study liposomal doxorubicin (SL-Dox) has been shown to be effective in advanced AIDS-related KS. In a single participating center 18 pts with endoscopi
Sanctuary growth of human immunodeficiency virus in the presence of AZT: implications for antiviral and antineoplastic therapy in patients with HIV infection (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A861 1996. Unique Identifier : AIDSLINE ICDB/97635861; Medina D; Tung PP; Strair RK; Cancer Institute of New Jersey, Robert Wood Johnson Medical; School, Piscataway, NJ; The current hypothesis for the failure of antiretroviral agents to completely inhibit HIV is the emergence of drug-resistant virus. This theory may explain the failure of the non-nucleoside reverse transcriptase inhibitors but it does not explain why AZT
Treatment of advanced epidemic Kaposi's sarcoma (EKS) with bleomycin or a combination of doxorubicin, bleomycin and vincristine (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A862 1996. Unique Identifier : AIDSLINE ICDB/97635862; Hernandez DE; Perez JR; Vargas Medical School, Universidad Central de Venezuela, 1070-A; Caracas, Venezuela; EKS remains the most common neoplastic complication of AIDS,affecting up to 20% of patients (pts). Twenty-four homosexual or bisexual male pts, between 21 and 49 years old (median age, 35) were included. Pts were clinically staged according to AIDS Clinical Trial Group (ACTG) criteria. Pts in both groups had more than
Systemic treatment with human chorionic gonadotropin (HCG) in patients (pts) with HIV-related Kaposi's sarcoma (KS) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A864 1996. Unique Identifier : AIDSLINE ICDB/97635864; Tavio M; Nasti G; Vaccher E; Errante D; Spina M; Simonelli C; Tirelli U; Div. of Medical Oncology and AIDS, C.R.O. National Cancer; Institute, 33081 Aviano, Italy; The beta-chain of human chorionic gonadotropin (HCG) is able to block tumorigenesis and metastasis of neoplastic KS cell line in immune deficient mice (Lunardi-Iskandar et al, Nature; 375:64-8 1995). Based on this data we began a clinical trial with escalating doses of HCG in 5 pts with HIV-KS, according to the follow
The interferon (INF) system in neoplastic and retroviral diseases (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A865 1996. Unique Identifier : AIDSLINE ICDB/97635865; Ambrus JL; Chadha K; Stadler S; Koreshi A; Department of Medicine, State University of NY at Buffalo,; Buffalo, NY; In patients with advanced AIDS and related lymphoma, acid labile alpha-INF and INF-inhibitory activity was found in the circulation. It prevented virus-induced INF production and antiviral and antineoplastic effect of human INF alpha, beta, and pi, but not INFS of other species. Similar inhibitory activity was found i
Phase I study - photodynamic therapy (PDT) for treatment of AIDS-associated Kaposi's sarcoma (AIDS/KS) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A866 1996. Unique Identifier : AIDSLINE ICDB/97635866; Bernstein ZP; Wilson D; Foulke L; Brooks J; Oseroff A; Bellnier D; Sumlin A; Mang TS; Dougherty T; Division of Medicine, Roswell Park Cancer Institute, Buffalo, NY; 14263; We have conducted a Phase I study utilizing PDT for palliative therapy of AIDS/KS without compromise of pts immune status. This therapy utilizes the activation by light of a photosensitizing drug (Photofrin) which preferentially accumulates in tumor tissues such as KS. All 26 entrants received 1.0 mg/kg of Photofrin
Immune recovery after cessation of chemotherapy (CT) in children with cancer (Ca) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A1776 1996. Unique Identifier : AIDSLINE ICDB/97636776; Mustafa MM; Buchanan GR; Winick NJ; Lipscomb M; Tkaczewski I; Ansari Q; Department of Pediatrics, University of Texas Southwestern; Medical Center, Dallas, TX 75235; We evaluated the humoral and cellular immunity of 43 children with Ca at completion of CT and every 3 mo thereafter for one yr. There were 17 pts with ALL, 17 with solid tumors and 9 with Hodgkin s disease. Their median age was 12 yr and they received CT for a median of 15 mo. Significant results are shown in a table.
A descriptive-exploratory study of outcome and some biopsychosocial characteristics of drug dependent veterans in Puerto Rico.: Bol Asoc Med P R. 1996 Jan-Mar;88(1-3):3-7. Unique Identifier : AIDSLINE MED/97039934; Santos EF; Diaz D; Martinez A; Gomez E; Visbal GN; I. OBJECTIVE: The authors attempted to correlate outcomes with various significant biopsychosocial variables in drug dependent veterans receiving outpatient treatment at San Juan V.A.M.C. II. METHODS: The clinical charts of 120 inactive patients were examined using a 50 item questionnaire. The data was processed and a
Opportunistic oral infections in the immunosuppressed patient: oral hairy leukoplakia and oral candidiasis.: Adv Dent Res. 1996 Apr;10(1):69-72. Unique Identifier : AIDSLINE MED/97089021; Sciubba JJ; Department of Dental Medicine, Long Island Jewish Medical Center,; New Hyde Park, New York, USA.; Several opportunistic infections associated with immunosuppression are noted to occur secondary to an altered relationship between host and organism. In relation to diminished host immunologic defenses, associated commensal organisms may evolve to a pathogen state. Candidiasis, a common oral marker disease reflective
Quantitation of HIV-1 p24 antibody expressed as relative binding capacity p24 antigen (p24 RBC) in infants born to HIV-1 seropositive mothers: correlation of this serological marker with the HIV-1 maternal antibody course and p24 antigenemia detection.: Viral Immunol. 1995;8(2):93-9. Unique Identifier : AIDSLINE MED/96422677; Portolani M; Meacci M; Pecorari M; Pietrosemoli P; Cermelli C; Cellini M; Tampieri A; Tartoni P; Stella F; Centre for Diagnosis of Viral Diseases, University of Modena,; Italy.; The antibody content to HIV-1 p24 Ag expressed as relative binding capacity to the target antigen (p24 RBC) was retrospectively quantified in serum samples from 20 HIV-1-uninfected infants born to HIV-1 seropositive mothers. p24 RBC values quantified at birth were included either in a low (0-20%) or high (80-100%) ran
Anti-idiotypic antibody to the V3 domain of gp120 binds to vimentin: a possible role of intermediate filaments in the early steps of HIV-1 infection cycle.: Viral Immunol. 1996;9(2):73-87. Unique Identifier : AIDSLINE MED/96419925; Thomas EK; Connelly RJ; Pennathur S; Dubrovsky L; Haffar OK; Bukrinsky MI; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.; Although the CD4 molecule is the major cellular receptor for human immunodeficiency virus (HIV), several lines of evidence suggest participation of additional molecules that are engaged after the binding of HIV to the CD4 receptor and that may facilitate viral entry into the target cell. Some of the post-CD4 binding,
The theatre: an effective tool for health promotion.: World Health Forum. 1996;17(1):64-9. Unique Identifier : AIDSLINE MED/96417355; Seguin A; Rancourt C; In Africa and in North America, in both rural and urban settings, theatre can be an effective means of health promotion. Projects on women s health, care for patients with mental disorders, and AIDS prevention show the usefulness of this medium for community action programmes.
Multisectoral strategy for AIDS prevention at community level.: World Health Forum. 1996;17(1):70-4. Unique Identifier : AIDSLINE MED/96417356; Elkins DB; Kuyyakanond T; Maticka-Tyndale E; Rujkorakarn D; Haswell-Elkins M; Northeast Centre for AIDS Prevention and Care, Khon Kaen; University, Thailand.; In north-east Thailand a five-act drama is broadcast on the village sound system to catalyse involvement in planning and carrying out AIDS prevention activities. Each community s own suggestions for an effective strategy are presented to the relevant government and nongovernmenta
Does AIDS emerge from a disequilibrium between two complementary groups of molecules that mimic MHC?: Immunol Today. 1996 Mar;17(3):114-9. Unique Identifier : AIDSLINE MED/96417477; Susal C; Daniel V; Opelz G; Department of Transplantation Immunology, Institute of; Immunology, University of Heidelberg, Germany.; caner.suesal@krzmail.krz.uni-heidelberg.de; There is increasing evidence that a disturbance of self-nonself-recognition plays an important role in the immunopathogenesis of AIDS. Here, Caner Susal, Volker Daniel and Gerhard Opelz speculate that the immune system is balanced between two groups of molecules that mimic major histocompatibility complex (MHC) protei
The role of host immune responses in determining the outcome of HIV infection.: Immunol Today. 1996 Mar;17(3):120-6. Unique Identifier : AIDSLINE MED/96417478; Westby M; Manca F; Dalgleish AG; Division of Oncology, Cellular and Molecular Sciences, St; George's Hospital Medical School, Tooting, UK.; dalgleis@sghms.ac.uk; The progression of disease following infection with human immunodeficiency virus (HIV) correlates with an activated immune system and would appear to depend to some degree o