HIV-related non-Hodgkin's lymphoma: centroblastic lymphoma (CL) is associated with better outcome than other histological subtypes (Meeting abstract).

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

HIV-related non-Hodgkin's lymphoma: centroblastic lymphoma (CL) is associated with better outcome than other histological subtypes (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 16:A161 1997. Unique Identifier : AIDSLINE MED/97622152
Vaccher E; Nasti G; Simonelli C; Santarossa S; Tirelli U; Division of Medical Oncology and AIDS, Aviano Cancer Center, PN),; Italy

Abstract: HIV-NHL represent an heterogeneous group of diseases, characterized by the presence of distinct molecular-pathological entities, but overall considered associated with a poor outcome. Controversy, however, exists concerning the outcome of CL. In this study we examined the relationship between pathological and clinical data obtained from a monoinstitutional series of 120 pts with HIV-NHL, diagnosed and treated with the same prospective chemotherapy protocols, from September 1987 to July 1995. All cases were intermediate-high grade NHL according to the WF and the updated Kiel classification. The main clinico-pathological correlations are reported in a table. Our results show a significant better outcome for CL (G group of WF) than NHL of H subgroup. Moreover CL, as well as Burkitt's type lymphoma, is found to have a lower degree of immunodeficiency than other histological subtypes. These data suggest that HIV-G NHL should not be included with HIV-H (immunoblastic) in the same category of diffuse large cell NHL, (Harris et al, 1994). (C) American Society of Clinical Oncology 1997

Keywords: *Antineoplastic Agents/THERAPEUTIC USE *Lymphoma, AIDS-Related/DRUG THERAPY *Lymphoma, AIDS-Related/PATHOLOGY
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M97C1601

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