Health advisory: high blood sugar and diabetes seen in protease inhibitor users. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Crit Path AIDS Proj. 1997 Summer;(No 32):28. Unique Identifier : AIDSLINE MED/97702727

Abstract: The Food and Drug Administration (FDA) has warned physicians that protease inhibitors may contribute to increased blood sugar or diabetes in HIV-positive patients, and recommends closely monitoring their glucose levels. These events occur relatively infrequently, and the FDA believes that the benefits of these drugs outweigh potential complications. All four approved protease inhibitors (saquinavir, indinavir, ritonavir, and nelfinavir) will soon carry revised labeling warning of this potential side effect. Patients taking protease inhibitors should be made aware of the warning signs of hyperglycemia and diabetes. The FDA's warning letter, detailing the effects, is included.

Keywords: *Diabetes Mellitus/CHEMICALLY INDUCED *Hyperglycemia/CHEMICALLY INDUCED *HIV Protease Inhibitors/ADVERSE EFFECTS
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