Major pediatric study stopped early: combination treatment better. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Major pediatric study stopped early: combination treatment better.

AIDS Treat News. 1997 Jul 4;(No 274):5-6. Unique Identifier : AIDSLINE MED/97702751
James JS; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Abstract: The National Institute of Allergy and Infectious Diseases (NIAID) stopped a clinical trial (ACTG 300) of more than 600 children because of obvious benefits of the combination of zidovudine AZT) plus lamivudine (3TC) over didanosine (ddI) monotherapy in reducing disease progression. The children had symptomatic HIV disease with little or no experience with antiretrovirals. A third treatment using AZT plus ddI also did better than using ddI alone, although there is less information on this arm of the study.
Keywords: *Anti-HIV Agents/THERAPEUTIC USE *Didanosine/THERAPEUTIC USE *HIV Infections/DRUG THERAPY *Lamivudine/THERAPEUTIC USE *Zidovudine/THERAPEUTIC USEKWDanti-hivagents/therapeuticuseKWDdidanosine/therapeuticuseKWDhivinfections/drugtherapyKWDlamivudine/therapeuticuseKWDzidovudine/therapeuticuse
971230
M97C1572

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