Of clades and quasispecies: making sense of the HIV population census.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Of clades and quasispecies: making sense of the HIV population census.

J Int Assoc Physicians AIDS Care. 1997 Jul;3(7):13-25. Unique Identifier : AIDSLINE MED/97702758
Mascolini M; Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD; 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Abstract: A great debate over the genetic evolution of HIV is under way. This article examines the many attempts to trace this evolution and includes discussions on how selection may drive HIV's evolution, and the controversy surrounding the effect of virion population and the difficulty in measuring it. Reasons clinicians should care which model of retroviral evolution is correct is also discussed. Other topics examined include: (1) research and theories involving where HIV finds sanctuary in order to rebound; 2) the problem of recombinants and HIV subtypes possibly changing the disease, thus making it more virulent or reshaping its transmission patterns; (3) the difficulty of cytotoxic T lymphocytes in clearing out HIV from the body; (4) and the issue of HIV eradication.

Keywords: *Drug Resistance/GENETICS *Evolution, Molecular *HIV/GENETICS
971230
M97C1566

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