Protease inhibitors linked to drop in CMV retinitis. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Protease inhibitors linked to drop in CMV retinitis. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

AIDS Alert. 1997 Aug;12(8):92-4. Unique Identifier : AIDSLINE MED/97702764

Abstract: Several studies suggest that protease inhibitor therapy is linked with a decrease in cases of cytomegalovirus (CMV) retinitis, as high as 50 percent at one institute. CMV retinitis afflicts about 40 percent of AIDS patients, and current treatment is intermittent intravenous ganciclovir, which can cause severe liver toxicity. The incidence of CMV retinitis is also related to CD4 counts, but clinicians are warned that rising CD4 counts do not necessarily mean that their patients are no longer at risk for developing CMV retinitis.

Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS *Acquired Immunodeficiency Syndrome/DRUG THERAPY *AIDS-Related Opportunistic Infections/DRUG THERAPY *Cytomegalovirus Retinitis/COMPLICATIONS *Cytomegalovirus Retinitis/DRUG THERAPY *CD4 Lymphocyte Count *HIV Protease Inhibitors/THERAPEUTIC USE
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