Opportunistic infections: stemming the tide. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Opportunistic infections: stemming the tide. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

J Int Assoc Physicians AIDS Care. 1997 Apr;3(4):42-7. Unique Identifier : AIDSLINE AIDS/97702491
MacDougall DS

Abstract: Reports from the 1997 Fourth Conference on Retroviruses and Opportunistic Infections reveal encouraging responses to the latest antiretroviral regimens, including using protease inhibitors for treating opportunistic infections. Unfortunately, there appears to be less interest in the development and validation of newer agents and regimens for opportunistic infection treatment and prevention. Reports are presented addressing the following areas: the impact of opportunistic infections on survival in HIV-infected patients; the success of protease inhibitors and antiretroviral therapy on opportunistic infections; the relationship of viral load plus CD4+ levels and prophylactic therapy for opportunistic infections. A report indicating that patients with a history of previous febrile reactions to trimethoprim/sulfamethoxazole (TMP/SMX) may be at increased risk of recurrence of TMP/SMX hypersensitivity following initiation of protease inhibitor therapy, and studies suggesting that, in HIV-infected patients, cytomegalovirus reactivation occurs a median of six months prior to the development of clinically detectable manifestations of cytomegalovirus infection are included. Questions on the length of prophylactic therapy and the role of prophylaxis in anergic patients who are being treated for Mycobacterium disease; risk factors associated with recurrent oral candidiasis in patients who received continuous antifungal therapy for less than three months; the detection of human herpesvirus eight DNA sequences in the semen of HIV-infected men without Kaposi's sarcoma; and occurrences of cervical dysplasia and genital tract infections in HIV-infected women are also discussed.

Keywords: AIDS-Related Opportunistic Infections/*PREVENTION & CONTROL Anti-HIV Agents/THERAPEUTIC USE CD4 Lymphocyte Count Candidiasis/COMPLICATIONS/PREVENTION & CONTROL Cytomegalovirus Infections/COMPLICATIONS/PREVENTION & CONTROL Female HIV Infections/*COMPLICATIONS/DRUG THERAPY Herpesviridae Infections/COMPLICATIONS/PREVENTION & CONTROL Human Male Mycobacterium avium-intracellulare Infection/COMPLICATIONS/ PREVENTION & CONTROL Papillomavirus, Human/ISOLATION & PURIF Pneumonia, Pneumocystis carinii/COMPLICATIONS/PREVENTION & CONTROL Tuberculosis/COMPLICATIONS/PREVENTION & CONTROL Tumor Virus Infections/COMPLICATIONS/PREVENTION & CONTROL/ VIROLOGY Viral Load NEWSLETTER ARTICLE
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M9781258

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