Pediatric update. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Pediatric update. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

PI Perspect. 1997 Mar;(No 21):12-3. Unique Identifier : AIDSLINE AIDS/97702499

Abstract: Data is just beginning to emerge concerning protease inhibitor use in children. Studies still require children to take single drugs for long periods, despite the evidence from adult studies showing that prolonged use of these drugs is improper; many children have developed resistance to these drugs. Children, like adults, should be treated with the most potent combination treatment regimen available. One study investigating AZT/ddI/ritonavir in children revealed only those using the highest doses had drops in viral load. Another study using AZT or d4T in 216 children revealed that children using d4T gained more weight and lost fewer CD4+ cells than those using AZT.

Keywords: Adolescence Anti-HIV Agents/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE CD4 Lymphocyte Count Child Child, Preschool Clinical Trials Drug Therapy, Combination HIV Infections/*DRUG THERAPY HIV Protease Inhibitors/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Human Infant Reverse Transcriptase Inhibitors/ADMINISTRATION & DOSAGE/ THERAPEUTIC USE Viral Load NEWSLETTER ARTICLE
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