The biological basis for psychoneuroimmunology. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

The biological basis for psychoneuroimmunology. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Focus. 1997 Feb;12(3):5-6. Unique Identifier : AIDSLINE AIDS/97702547
Cole SW; University of California Los Angeles, School of Medicine, Los; Angeles, CA.

Abstract: The brain and the immune system are linked by two major physiologic systems: the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal system (HPA). The effect of these systems on the immune system is related to HIV disease and HIV-related care. The SNS and the HPA both play roles in normal body function and become particularly active during stressful or emotional circumstances. These experiences are associated with increased activity in the brain's limbic system. Research suggests that SNS activation can reduce cellular immune response. Some aspects of the immune function can be altered by the network of hormones that make up the HPA system. Research is necessary to determine whether or not psychological characteristics associated with differences in the rate of HIV progression might be mediated by the activity of the SNS and HPA.

Keywords: Disease Progression *HIV Infections Human Immune System/*PHYSIOLOGY Neurosecretory Systems/IMMUNOLOGY/*PHYSIOLOGY Pituitary-Adrenal System/IMMUNOLOGY/*PHYSIOLOGY *Psychoneuroimmunology Sympathetic Nervous System/IMMUNOLOGY/*PHYSIOLOGY NEWSLETTER ARTICLE
970830
M9781204

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