Spring cleaning in trial land. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Spring cleaning in trial land. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.

GMHC Treat Issues. 1997 Mar;11(3):4-7. Unique Identifier : AIDSLINE AIDS/97702563
Gilden D

Abstract: Several clinical trials have been shut down earlier than planned, following the striking results shown in the trials. ACTG 320, studying whether an AZT/3TC combination was more effective if indinavir was added, was opposed early on because it seemed a waste of resources. The risk of disease progression was halved when indinavir was added. Merck Protocol 028, another disease progression trial, targeted a treatment-naive population with advanced HIV. The trial took place in Brazil because the AIDS-infected population had less access to treatment than people in the U.S., and was halted immediately following a major newspaper article on it. ACTG 333 tested the consequences of long-term use of hard capsule saquinavir, and found that it is poorly absorbed and there is only a very modest effect on HIV.

Keywords: Anti-HIV Agents/ADMINISTRATION & DOSAGE Brazil CD4 Lymphocyte Count/DRUG EFFECTS *Clinical Trials Disease Progression Drug Resistance, Microbial Drug Therapy, Combination HIV Infections/*DRUG THERAPY HIV Protease Inhibitors/ADMINISTRATION & DOSAGE Human Indinavir/ADMINISTRATION & DOSAGE Lamivudine/ADMINISTRATION & DOSAGE Saquinavir/ADMINISTRATION & DOSAGE Stavudine/ADMINISTRATION & DOSAGE United States Viral Load Zidovudine/ADMINISTRATION & DOSAGE NEWSLETTER ARTICLE
970830
M9781188

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