Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
[ABC of the antivirals] Project Inform. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.
Abstract:
Scientists have tried to inhibit or slow down the HIV virus ever since the virus was identified as the cause of AIDS. Although the efforts have not produced a long-term solution, significant progress has been made. There is a correlation between the increase in HIV levels and the advanced state of the disease. Antiviral therapies are discussed, including when to start the treatment, what drugs to use, and how to find out if the treatment is working. Some of the drugs seem to stop the replication of the HIV virus; however, they do not eradicate the virus. AZT (zidovudine/Retrovir), ddI (didadosine/Videx), ddC (zalcitabine/Hivid), d4T (stavudine/Zerit) and 3TC (lamivudine/Epivir) are some of the most common drugs on the market today. Information on research, side effects, doses, interactions with other drugs, and where to get these drugs is provided. Protease inhibitors, another type of drug, include saquinavir, ritonavir and indinavir (Crixivan). Much research has been done with these drugs, however, they are very difficult to produce. The combination of AZT and 3TC have shown positive results, and the future of antiviral therapies seems to be heading toward combination therapy.
Keywords: Anti-HIV Agents/ADVERSE EFFECTS/PHARMACOLOGY/*THERAPEUTIC USE Drug Therapy, Combination HIV/DRUG EFFECTS/PHYSIOLOGY HIV Infections/*DRUG THERAPY HIV Protease Inhibitors/ADVERSE EFFECTS/PHARMACOLOGY/*THERAPEUTIC USE Human Virus Replication/DRUG EFFECTS NEWSLETTER ARTICLE 970830
M9781171
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